ライフサイエンスコーパス: adenosine 5'-diphosphate

1 platelet aggregation but normal responses to adenosine 5'-diphosphate.

2 platelet activation in vitro in response to adenosine 5'-diphosphate.

3 mong a panel of substrate analogs, including adenosine 5'-diphosphate.

4 rombin receptor activator peptide-6 (0.55) > Adenosine-5'-diphosphate (1.02) > collagen (1.56)] and r

5 n complex with the full agonist 2-methylthio-adenosine-5'-diphosphate (2MeSADP, a close analogue of e

6 numerous agonists (collagen-related peptide, adenosine 5'-diphosphate, A23187, thrombin, or U46619).

7 This released adenosine-5'-diphosphate, acting through P2Y(12), is cri

8 In adenosine 5'-diphosphate-activated HMEC-1, also sera fro

9 ogical CD73 inhibition (alpha,beta-methylene adenosine-5-diphosphate), adenosine receptor A2B (ADORA2

10 tions of adenosine 5'-triphosphate (ATP) and adenosine 5'-diphosphate (ADP) and guanosine conformatio

11 Even low amounts of adenosine 5'-diphosphate (ADP) and inosine 5'-monophosph

12 the Dictyostelium motor domain with bound Mg.adenosine 5'-diphosphate (ADP) and P(i), modeled upon th

13 ctivities by long-term culture with 2 mmol/L adenosine 5'-diphosphate (ADP) and Pi sensitized both dr

14 rioles to endothelium-dependent vasodilators adenosine 5'-diphosphate (ADP) and substance P and the e

15 Adenosine 5'-diphosphate (ADP) induces platelet aggregat

16 greater extent compared with the addition of adenosine 5'-diphosphate (ADP) or adenosine 5'-monophosp

17 nhibition of platelet aggregation induced by adenosine 5'-diphosphate (ADP) or low concentrations of

18 tein accumulation, as does either inhibiting adenosine 5'-diphosphate (ADP) P2Y12receptors or reducin

19 blood and flow conditions, it was shown that adenosine 5'-diphosphate (ADP) receptors P2Y(12) and P2Y

20 the ATP binding in one beta subunit and the adenosine 5'-diphosphate (ADP) release from another beta

21 udlak syndrome (HPS) as a model to show that adenosine 5'-diphosphate (ADP) released by dense granule

22 High agonist doses or supplemental adenosine 5'-diphosphate (ADP) restored normal alpha gra

23 hate (cAMP) in the platelet cytosol, such as adenosine 5'-diphosphate (ADP) secreted from dense granu

24 block polymerization was crystallized in the adenosine 5'-diphosphate (ADP) state, and the structure

25 were caused by the release of extracellular adenosine 5'-diphosphate (ADP) that activated P2Y1 purin

26 oides accomplish the photophosphorylation of adenosine 5'-diphosphate (ADP) to ATP, functioning as na

27 upled receptor P2Y1 (P2Y1 R) is activated by adenosine 5'-diphosphate (ADP) to induce platelet activa

28 It degrades adenosine 5'-diphosphate (ADP), a main platelet activati

29 coenzymes (adenosine 5'-triphosphate (ATP), adenosine 5'-diphosphate (ADP), adenosine 5'-monophospha

30 ists, but they enhanced response to low-dose adenosine 5'-diphosphate (ADP), epinephrine, or serotoni

31 nd the apparent inhibition constant (Ki) for adenosine 5'-diphosphate (ADP), which compared favorably

32 on associated with a lower affinity for DNA (Adenosine 5'-diphosphate (ADP)-bound).

33 Adenosine 5'-diphosphate (ADP)-glucose pyrophosphorylase

34 ticagrelor promoted a greater inhibition of adenosine 5'-diphosphate (ADP)-induced Ca(2+) release in

35 d "old/weak." The "young/strong" state 1 has adenosine 5'-diphosphate (ADP)-P (i) bound to Arp2/3 com

36 The enzyme poly(adenosine 5'-diphosphate (ADP)-ribose) polymerase (PARP-

37 ions, little is known about the role of poly[adenosine 5'-diphosphate (ADP)-ribose] in chromatin remo

38 Evidence suggests that one such PTM, adenosine 5'-diphosphate (ADP)-ribosylation, is importan

39 hat the Dombrock molecule is a member of the adenosine 5'-diphosphate (ADP)-ribosyltransferase ectoen

40 This process is mediated by mono-adenosine 5'-diphosphate (ADP)-ribosyltransferases (ARTs

41 at the transporter has a higher affinity for adenosine 5'-diphosphate (ADP).

42 eleasing platelet-activating factors such as adenosine 5'-diphosphate (ADP).

43 ected by addition of subthreshold amounts of adenosine 5'-diphosphate (ADP).

44 revealed enhanced binding in the presence of adenosine 5'-diphosphate (ADP).

45 ciated with increased platelet reactivity to adenosine 5'-diphosphate (ADP).

46 The mitochondrial adenosine 5'-diphosphate (ADP)/adenosine 5'-triphosphate

47 1-ATPase respectively regulate mitochondrial adenosine 5'-diphosphate (ADP)/ATP exchange and ADP-phos

48 cross-selectivity was demonstrated with the adenosine-5'-diphosphate (ADP) imprinting and ATP discri

49 telet agonists (U-46619, alpha-thrombin, and adenosine 5'-diphosphate [ADP]) induced a [Ca2+]i signal

50 Poly(adenosine 5'-diphosphate [ADP]-ribose)-polymerase (PARP)

51 inant wild-type (WT) Rhodobacter sphaeroides adenosine 5'-diphosphate-(ADP)-glucose pyrophosphorylase

52 nucleotidase inhibitor, alpha,beta-methylene adenosine 5'-diphosphate (AMP-CP), and a competitive sub

53 y [beta-32P]-8-(4-bromo-2, 3-dioxo-butylthio)adenosine-5'-diphosphate, an ADP-affinity analog that se

54 displayed reduced aggregation in response to adenosine 5'-diphosphate and epinephrine, but variable a

55 e, while the shell was heavily influenced by adenosine 5'-diphosphate and regulators of Gi2-mediated

56 II in the motor and enhances fluctuations in adenosine 5'-diphosphate and the residues in the binding

57 Moreover, feedback agonists adenosine 5'-diphosphate and thromboxane A2 are mandator

58 ng peptide, an increased maximum response to adenosine 5'-diphosphate and TxA2, and a greatly exagger

59 in an open, outward-facing conformation with adenosine 5'-diphosphate and vanadate, revealing a disti

60 apped in an outward-facing conformation with adenosine 5'-diphosphate and vanadate.

61 and P2ry14-purinergic receptors activated by adenosine 5-diphosphate and UDP-sugars, respectively-wer

62 stimulation elicited by 10 nM 2-(methylthio)adenosine 5'-diphosphate (antagonist effect).

63 nucleotidase inhibitor alpha, beta-methylene adenosine-5'-diphosphate (APCP) abrogates completely the

64 on in platelet sensitivity to aggregation by adenosine 5'-diphosphate, arachidonic acid, and phorbol

65 Finally, the location of the adenosine 5'-diphosphate binding site within the nucleot

66 nucleotidase inhibitor (alpha,beta-methylene adenosine-5'-diphosphate) blocked the effect of MTX, ade

67 ranules and GPIIb-IIIa activation induced by adenosine 5'-diphosphate, convulxin, and thrombin; (3) s

68 Other nucleotide-glucose compounds (adenosine-5'-diphosphate-D-glucose, guanosine-5'-diphosp

69 ound that deoxy-hydrolysis products [2-deoxy-adenosine 5'-diphosphate (dADP) and inorganic phosphate

70 x status of cPABP through redox potential or adenosine 5'-diphosphate-dependent phosphorylation.

71 aride treatment reduced the rate of state 3 (adenosine 5'-diphosphate-dependent) respiration, especia

72 Adenosine, adenosine 5'-monophosphate, or adenosine 5'-diphosphate did not excite these fibres (n

73 he properties of the starch synthesis enzyme adenosine 5'-diphosphate-glucose pyrophosphorylase (AGPa

74 ex with three inhibitors: ADP-ribose (ADPR), adenosine 5'-diphosphate (hydroxymethyl)pyrrolidinediol

75 tly phosphorylated by thrombin compared with adenosine 5'-diphosphate in platelets.

76 ibition), and increased the rate of state 4 (adenosine 5'-diphosphate-independent) respiration, refle

77 vasodilatation and abolished substance P- or adenosine 5 diphosphate-induced relaxation (P<0.05), but

78 x min) in the placebo group (P = .02), while adenosine 5'-diphosphate-induced aggregation was not aff

79 ffinity for 2'-(3')-O-(N-methylanthraniloyl) adenosine 5'-diphosphate (mant ADP), similar to the sing

80 Finally, ADP, 2'-O-(N-methylanthraniloyl)-adenosine-5'-diphosphate (MANT-ADP), and adenosine 5'-O-

81 ates (MANT-ADP, 3',2'-O-(N-methylantraniloyl)adenosine-5'-diphosphate; MANT-GDP, 3',2'-O(N-methylantr

82 t ADP analog, 2'(3')-O-(N-methylanthraniloyl)adenosine 5'-diphosphate (mantADP) from the active site

83 nt analogue 2'-(3')-O-(N-methylanthraniloyl) adenosine 5'-diphosphate (mantADP) to report microtubule

84 Studies of patients with defective adenosine-5'-diphosphate mediated aggregation, as well a

85 e occupied uniquely by the combination of an adenosine 5'-diphosphate molecule with no magnesium ion

86 ll, releasing its energy via hydrolysis into adenosine 5'-diphosphate or ADP.

87 othelial growth factor (VEGF) in response to adenosine 5'-diphosphate or tumor cells (MCF-7 cells) an

88 t bind to adenosine, adenosine triphosphate, adenosine 5'-diphosphate, or structurally related drugs.

89 The hydrolyzed product, adenosine 5'-diphosphate orients the surface of GlnK for

90 metabolic function (adenosine 5-triphosphate/adenosine 5-diphosphate ratio, nicotinamide adenine dinu

91 Structures of FDH.adenosine 5'-diphosphate ribose (ADP-ribose) and E67L.NA

92 Binding of the nucleotide adenosine 5'-diphosphate ribose (ADPR) to the cytosolic

93 Cyclic adenosine 5'-diphosphate ribose (cADPR) analogs based on

94 Stable cyclic adenosine 5'-diphosphate ribose (cADPR) analogues are ch

95 (2+)-mobilising messengers, including cyclic adenosine 5'-diphosphate ribose (cADPR), and CD38 knocko

96 c concept exemplified by inhibition of poly-(adenosine 5'-diphosphate ribose) polymerase or the ataxi

97 Inositol trisphosphate (InsP3) and cyclic adenosine 5'-diphosphate-ribose (cADPR) are established

98 often enzymes that produce isomers of cyclic adenosine 5'-diphosphate-ribose (cADPR) as putative immu

99 Poly(adenosine 5'-diphosphate-ribose) polymerase (PARP) inhib

100 ne negativity, annexin positivity, and poly (adenosine 5'-diphosphate-ribose) polymerase cleavage.

101 in resistant clones, and inhibition of poly(adenosine 5'-diphosphate-ribose) polymerase synergizes w

102 that GzmA cleaves the DNA damage sensor poly(adenosine 5'-diphosphate-ribose) polymerase-1 (PARP-1) a

103 ition, according to the crystal structure of adenosine-5-diphosphate-ribose (ADP-ribose) in complex w

104 mitant with this blocking, cleavage of poly (adenosine 5'-diphosphate--ribose) polymerase and activat

105 3 and induced caspase 3 activation, poly(ADP[adenosine 5'-diphosphate]-ribose) polymerase (PARP) clea

106 vidence suggests that the peroxynitrite-poly-adenosine 5'-diphosphate ribosyl polymerase pathway cont

107 equent activation of the nuclear enzyme poly-adenosine 5'-diphosphate ribosyl synthetase, and eventua

108 x group in the phosphorylated state with the adenosine-5-diphosphate-ribosylarginine (ADP-RA) complex

109 their attention to endocytosis and show that adenosine 5'-diphosphate-ribosylation factor 6 (Arf6) pl

110 coupled with immunodetection methods and an adenosine 5(')-diphosphate-ribosylation assay to measure

111 '-triphosphate, uridine 5'-triphosphate, and adenosine 5'-diphosphate significantly increased prolife

112 yed comparable initial aggregation following adenosine 5'-diphosphate stimulation, but Fga270/270 pla

113 ubendothelium under high shear, they release adenosine-5'-diphosphate that acts in a positive feedbac

114 In response to adenosine 5'-diphosphate, the P2Y1 receptor (P2Y1R) faci

115 ignaling mechanisms in platelets mediated by adenosine-5'-diphosphate through the P2Y(12) receptor.

116 ATP site and 2'(3')-O-(2,4,6-trinitrophenyl)adenosine 5'-diphosphate (TNP-ADP) was used to probe the

117 sence of ATP, 2'(3')-O-(2,4,6-trinitrophenyl)adenosine 5'-diphosphate (TNP-AMP), or an fluoroisothioc

118 ting concentrations of fibrillar collagen or adenosine 5'-diphosphate, uniquely assemble an IQGAP2/ar

119 Microvessel relaxation response to adenosine 5'-diphosphate was improved in the HCW group a

120 nd that of the agonists ADP and 2-methylthio-adenosine-5'-diphosphate, was reduced.