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1 y cytokines most likely by activation of the adenosine A2a receptor.
2  in a high-resolution structure of the human adenosine A2A receptor.
3  occurred when PKA was activated through the adenosine A2a receptor.
4 egulates the macrophage response through the adenosine A2A receptor.
5  wakefulness by antagonizing function of the adenosine A2A receptor.
6 n response to pharmacological stimulation of adenosine A2A receptors.
7  the NTS by way of activation of presynaptic adenosine A2a receptors.
8 ion by neutrophils via occupancy of specific adenosine A2A receptors.
9 lular adenosine and activation of Gs-coupled adenosine A2A receptors.
10 al spike patterns and requires activation of adenosine A2A receptors.
11  (or Galpha(olf)) coupled to dopamine D1 and adenosine A2A receptors.
12 r the adenosine A1 receptor (915-fold versus adenosine A2A receptor; 12-fold versus adenosine A2B rec
13 te dose of caffeine (antagonist for A1Rs and adenosine A2A receptors; 4 mg/kg intraperitoneally; diss
14                                          The adenosine A2A receptor (A(2A)R) plays a key role in tran
15 adenosine receptor antagonist) and selective adenosine A2A receptor (A2A R) blockade alleviate neurod
16                    The duration of action of adenosine A2A receptor (A2A) agonists is critical for th
17 ese regions also have the highest density of adenosine A2a receptors (A2a) in the brain.
18                                              Adenosine A2A receptor (A2AR) activation in cartilage vi
19              We previously demonstrated that adenosine A2A receptor (A2AR) agonism attenuates lung is
20                                              Adenosine A2A receptor (A2AR) agonists are known to pote
21                                              Adenosine A2A receptor (A2AR) agonists reduce invariant
22                                              Adenosine A2A receptor (A2AR) agonists with Toll-like re
23 inoid receptors present in the striatum, ie, adenosine A2A receptor (A2AR) and cannabinoid CB1 recept
24 ced in the mutants and this was dependent on adenosine A2A receptor (A2AR) and tropomyosin-related ki
25 ith depression and memory deterioration, and adenosine A2A receptor (A2AR) antagonists emerge as cand
26           Endogenous adenosine acting at the adenosine A2A receptor (A2AR) can modify brain injury in
27 e describe the spontaneous reconstitution of adenosine A2A receptor (A2AR) during the de novo formati
28  this study was to examine the regulation of adenosine A2A receptor (A2AR) gene expression during hyp
29               We produced mice with a floxed adenosine A2A receptor (A2AR) gene, Adora2a, and show th
30                                          The adenosine A2A receptor (A2AR) has long been implicated i
31 nvestigated the specific requirements of the adenosine A2A receptor (A2AR) in mature adipocytes for t
32 ealed a 43-fold upregulation of mRNA for the adenosine A2A receptor (A2AR) in WT allografts compared
33                                          The adenosine A2A receptor (A2AR) is a particularly interest
34                                          The adenosine A2A receptor (A2AR) is a potent anti-inflammat
35                                          The adenosine A2A receptor (A2AR) is expressed in lymphatic
36                           We previously used adenosine A2A receptor (A2AR) knockout (KO) mice and bon
37 thanol-induced sleep using C57BL/6Slac mice, adenosine A2A receptor (A2AR) knockout mice, and their w
38 ll molecule pharmacophore that activates the adenosine A2A receptor (A2AR) linked to antibody fragmen
39                                Activation of adenosine A2A receptor (A2AR) promotes fibrosis and coll
40                                              Adenosine A2a receptor (A2aR) signaling acts as a barrie
41               Here, we show the necessity of adenosine A2A receptor (A2AR) signaling and the GSH/GPX4
42 Synergy between Toll-like receptor (TLR) and adenosine A2A receptor (A2AR) signaling switches macroph
43 racellular adenosine resulting in diminished adenosine A2A receptor (A2AR) stimulation and altered ch
44                                              Adenosine A2A receptor (A2AR) stimulation promotes wound
45 umans by counteracting overactivation of the adenosine A2A receptor (A2AR), which is upregulated in t
46 e reduced oxygen-induced neural apoptosis by adenosine A2A receptor (A2AR)-dependent mechanism, as re
47 sed basal synaptic transmission and enhanced adenosine A2A receptor (A2AR)-dependent synaptic plastic
48                                              Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R)
49  to investigate the mechanism underlying the adenosine A2a receptor (A2aR)-mediated positive inotropi
50 sity and morphology, and upregulation of the adenosine A2A receptor (A2AR).
51                                Activation of adenosine A2A receptors (A2AR) has been shown to antagon
52                                              Adenosine A2A receptors (A2AR) modulate dopamine and glu
53                                     Striatal adenosine A2A receptors (A2AR) play an essential role in
54          Although T cells express inhibitory adenosine A2A receptors (A2AR) that suppress their activ
55                                     Cerebral adenosine A2A receptors (A2ARs) are attractive therapeut
56                                              Adenosine A2A receptors (A2ARs) are enriched in the stri
57                                              Adenosine A2A receptors (A2ARs) are highly expressed in
58                                        Since adenosine A2A receptors (A2ARs) control lysosome traffic
59 d reference memory through the antagonism of adenosine A2A receptors (A2ARs) controlling synaptic pla
60                                 In contrast, adenosine A2A receptors (A2ARs) did not coprecipitate or
61        Indeed, pharmacological inhibition of adenosine A2A receptors (A2ARs) significantly reverses S
62                                Activation of adenosine A2A receptors (A2ARs) stimulates bone formatio
63 ladenant) was developed for mapping cerebral adenosine A2A receptors (A2ARs) with PET.
64 ced by lymphocyte depletion or activation of adenosine A2A receptors (A2ARs) with the selective agoni
65                       We recently found that adenosine A2A receptors (A2ARs), which control synaptic
66 lzheimer's disease through the antagonism of adenosine A2A receptors (A2ARs).
67 tivation/deactivation mechanism of the human adenosine A2A receptor (AA2AR), a member of the class A
68 h pathways were modulated by dopamine D2 and adenosine A2A receptors, acting through cAMP/PKA.
69                                     Instead, adenosine A2A receptor activation of G alpha(s/olf) seem
70                  However, the combination of adenosine A2A receptor activation with either isoflurane
71 induced a better neuroprotective effect than adenosine A2A receptor activation, isoflurane preconditi
72                                      Through adenosine A2A receptor activation, MTX promotes reverse
73 volve CaMKII inhibition, but may not involve adenosine A2A receptor activation.
74                        Accordingly, reducing adenosine A2A receptor activity in Adk(Deltabrain) mice
75                       Here, we show that the adenosine A2a receptor (ADORA2A) promotes hypoxia-induci
76 Studies with CGS21680, a specific agonist of adenosine A2A receptor (AdoRA2A), and ZM241385, an AdoRA
77 any of its effects via antagonist binding to adenosine A2a receptors (ADORA2A).
78  agonist N6-cyclohexyladenosine (CHA) or the adenosine A2a receptor agonist 2-[(2-aminoethylamino)car
79                             In contrast, the adenosine A2A receptor agonist 2-p-(2-carboxyethyl)-phen
80                        Pretreatment with the adenosine A2a receptor agonist APEC, but not the adenosi
81                                The selective adenosine A2A receptor agonist binodenoson results in an
82 nosine and a second study with the selective adenosine A2A receptor agonist binodenoson, using 1 of 4
83 PA (2-chloro-N6-cyclopentyladenosine) or the adenosine A2A receptor agonist CGS 21680 (2-p-(2-carboxy
84             We hypothesized that a selective adenosine A2A receptor agonist would induce coronary vas
85  in maximal vessel response to CGS-21680, an adenosine A2A receptor agonist, but did not alter the co
86 arboxamidoadenosine (CGS 21680), a selective adenosine A2a receptor agonist, for 5 min prior to the S
87                                          The adenosine A2A receptor and PDE2, 3, 4, and 7 are importa
88           These effects are mediated via the adenosine A2A receptor and protein kinase A (PKA).
89  VEGF gene expression through stimulation of adenosine A2a receptor and subsequent activation of the
90 ly explained by genetic polymorphisms of the adenosine A2A receptors and alpha(2)-adrenergic receptor
91  a partner for the carboxyl-terminal tail of adenosine A2A receptors and showing that this interactio
92 ckade of a transactivation pathway that uses adenosine A2a receptors and src-family kinases (SFKs).
93 bbles by 70% (P<0.01), whereas inhibition of adenosine-A2a receptors and epoxyeicosatrienoic acids ha
94  in response to adenosine (via activation of adenosine A2A receptors) and to further determine the si
95                                        TrkB, adenosine A2a receptors, and SFKs associate into complex
96                                          The adenosine A2a receptor antagonist 8-(3-chlorostyryl)caff
97 kade of glutamate release by perfusion of an adenosine A2A receptor antagonist in the pmNAc shell blo
98 present study, we show that the FDA-approved adenosine A2A receptor antagonist istradefylline (KW6002
99 aling downstream of CD39 using the selective adenosine A2a receptor antagonist istradefylline.
100                                    The novel adenosine A2A receptor antagonist KW-6002 has been exami
101                        Different doses of an adenosine A2A receptor antagonist MSX-3 [3,7-dihydro-8-[
102    Tozadenant (SYN115) is an oral, selective adenosine A2A receptor antagonist that improves motor fu
103 pentyl-1,3-dipropylxanthine), or a selective adenosine A2A receptor antagonist ZM 241385.
104 en demonstrated to be a potent and selective adenosine A2a receptor antagonist, although with limited
105 te mice, C57BL/6 mice, and mice treated with adenosine A2A receptor antagonist.
106 1 receptor antagonist but not by a selective adenosine A2A receptor antagonist.
107 hibitory effects were reduced by addition of adenosine A2A receptor antagonist.
108 mine D2 receptor agonist and ZM 241385 as an adenosine A2A receptor antagonist.
109 esulted in discovery of potent and selective adenosine A2A receptor antagonists bearing substituted 1
110                                              Adenosine A2A receptor antagonists provide a promising n
111         These results suggest that selective adenosine A2A receptor antagonists represent a new class
112  structural information for the discovery of adenosine A2A receptor antagonists that have potential t
113 ly expressed in striatonigral neurons, while adenosine A2a receptors are preferentially expressed in
114 tissue-nonspecific alkaline phosphatase, and adenosine A2a receptors are significantly increased in d
115  While it is well-known that dopamine D2 and adenosine A2a receptors bi-directionally regulate iSPN p
116 A receptor ligand, showed that the number of adenosine A2A receptor binding sites was similarly incre
117                We therefore examined whether adenosine A2A receptors contribute to the pathogenesis o
118                                              Adenosine A2A receptor-deficient and A2A receptor antago
119 leomycin-induced dermal fibrosis model using adenosine A2A receptor-deficient wild-type littermate mi
120                           Herein we describe adenosine A2A receptor distribution, signaling pathways,
121 ha), from dopamine D1 receptor-expressing or adenosine A2a receptor-expressing medium spiny neurons (
122 ter, and adenosine A1 receptor and decreased adenosine A2A receptor expression in the NAc.
123 olution X-ray crystal structure of the human adenosine A2A receptor (hA2AAR), in which the allosteric
124                                          The adenosine A2A receptor has emerged as an attractive non-
125                                              Adenosine A2A receptor immunoreactivity (A2A-LI) has bee
126 collagen production after stimulation of the adenosine A2A receptor in a dose-dependent fashion.
127                              Blockade of the adenosine A2A receptor in striatopallidal neurons reduce
128 s- and Golf-coupled dopamine D1 receptor and adenosine A2A receptor in the brain and other organs, el
129                                              Adenosine A2A receptors in striatum are selectively loca
130 It was also apparent that this population of adenosine A2a receptors in the NTS desensitized within 2
131                      These results show that adenosine A2A receptor-induced protection is most likely
132 ncology despite the safe clinical profile of adenosine A2A receptor inhibitors (A2ARi) in Parkinson d
133 on pathways by which occupancy of neutrophil adenosine A2A receptors inhibits superoxide anion genera
134                                          The adenosine A2A receptor is a G-protein-coupled receptor (
135                                          The adenosine A2A receptor is a prototypical rhodopsin-like
136                                 The cerebral adenosine A2A receptor is an attractive therapeutic targ
137 VHD, and the pharmacologic activation of the adenosine A2A receptor is protective.
138 -isomer (Sp-cAMPS), prostaglandin E1, or the adenosine A2A receptor is sufficient to cause epsilonPKC
139 ntially therapeutic dopamine D1 receptor and adenosine A2A receptor ligands with functionally selecti
140                                              Adenosine A2A receptor ligation stimulated ERK phosphory
141                We observed that the striatal adenosine A2A receptor links adenosine tone and psychomo
142 ening inflammation through signaling via the adenosine A2A receptor may limit tissue damage but may a
143 termine the signaling mechanisms involved in adenosine A2A receptor-mediated promotion of collagen pr
144 cological inhibitors of signal transduction, adenosine A2A receptor-mediated stimulation of procollag
145 al-regulated kinase (erk), but surprisingly, adenosine A2A receptor-mediated stimulation of procollag
146                                          The adenosine A2a receptor mediates a new cyclic AMP-indepen
147 tributes to the development of OA; targeting adenosine A2A receptors might treat or prevent OA.
148                                              Adenosine A2A receptor occupancy promoted collagen produ
149 pression of CD39/CD73 on T reg cells and the adenosine A2A receptor on activated T effector cells gen
150 rior studies indicate that adenosine and the adenosine A2A receptor play a role in hepatic fibrosis b
151               These results demonstrate that adenosine A2A receptors play an active role in the patho
152 egulates inflammation and tissue repair, and adenosine A2A receptors promote wound healing by stimula
153 aspartate (NMDA) receptors, or activation of adenosine A2A receptors resulted in reduction of the OGD
154 on, we demonstrate that beta2-adrenergic and adenosine A2A receptors scramble lipids, suggesting that
155                     Selective agonism of the adenosine A2A receptor should result in a similar degree
156                  These results indicate that adenosine A2A receptors signal for increased collagen pr
157 2 (CK2) negatively regulates dopamine D1 and adenosine A2A receptor signaling in the striatum.
158 tivity, reducing EAAT2 function or enhancing adenosine/A2a receptor signaling.
159  27-hydroxylase and ABCA1 was blocked by the adenosine A2A receptor-specific antagonist ZM241385.
160 and this modulation is primarily through the adenosine A2a receptor subtype.
161 cal GPCRs with known crystal structures: the adenosine A2A receptor, the beta2-adrenergic receptor an
162 latory response is mediated primarily by the adenosine A2A receptors, these side effects result from
163 immediate tissue-protecting mechanisms, with adenosine A2A receptors triggering "OFF" signals in acti
164  report the discovery of an acid sensor, the adenosine A2a receptor, which can be activated solely by
165        A minority of microglia expressed the adenosine A2A receptor, which has been linked with proce
166 on of Th1 and Th2 cells in vitro depended on adenosine A2A receptors, which were also required for th
167 esent study, we demonstrate that blockade of adenosine A2A receptors with caffeine or a selective A2A

 
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