ライフサイエンスコーパス: adenosyl

1 ed by a failure to metabolize cobalamin into adenosyl- and methylcobalamin, which results in the bioc

2 -C bond dissociation energies in the related adenosyl- and methylcobinamides (41.5 +/- 1.2 and 44.6 +

3 to the cofactor forms methyl-Cbl (MeCbl) and adenosyl-Cbl (AdoCbl) is required for the function of tw

4 (Cbl)), in the cofactor forms methyl-Cbl and adenosyl-Cbl, is required for the function of the essent

5 er RNAs, appears to be regulated by a single adenosyl cobalamine (AdoCbl)-responsive riboswitch.

6 methylenetetrahydrofolate reductase (Mthfr), adenosyl-homocysteinase (Ahcy), and methylenetetrahydrof

7 enzyme, PaMTH1-SAM (co-factor), and PaMTH1-S-adenosyl homocysteine (by-product) co-complexes refined

8 matography/mass spectrometry (LC/MS)-based S-adenosyl homocysteine (SAH) detection assay for histone

9 Here, we describe a suite of S-adenosyl homocysteine (SAH) photoreactive probes and the

10 n the free form and a ternary complex with S-adenosyl homocysteine and a histone H3 peptide and bioch

11 the expression of DNMT1, MMP9, TIMP1, and S-adenosyl homocysteine hydrolase (SAHH) and upregulated m

12 1), and the decreased S-adenosylmethionine/S-adenosyl homocysteine ratio (P<0.01).

13 hen PIMT protein binding was poisoned with S-adenosyl homocysteine.

14 ce and absence of its methyl donor product S-adenosyl-homocysteine (SAH) and its ortholog scTrm10 fro

15 ility possibly reflected in high levels of S-adenosyl-homocysteine (SAH) and low levels of S-adenosyl

16 AM), which is converted via methylation to S-adenosyl-homocysteine (SAH), which accumulates during ag

17 that 1 equiv each of 5'-deoxyadenosine and S-adenosyl-homocysteine are produced for each methylation

18 aelis-Menten kinetics, and is inhibited by S-adenosyl-homocysteine.

19 e the resulting peptide with tritiated S-(5'-adenosyl)-l-methionine.

20 itors and immunoprecipitation of RyR2 from S-adenosyl-l-[methyl-(3)H]methionine ([(3)H]SAM) pretreate

21 from yeast cells radiolabeled in vivo with S-adenosyl-l-[methyl-(3)H]methionine.

22 analysis of Rpl3 radiolabeled in vivo with S-adenosyl-l-[methyl-(3)H]methionine.

23 d reductant and then incubated with excess S-adenosyl-l-[methyl-d3]methionine in the presence of subs

24 previously undescribed co-factor, carboxy-S-adenosyl-l-ethionine (cxSAE), thereby enabling the stere

25 ere we present synthesis of the SAM analog S-adenosyl-l-ethionine (SAE) and show SAE is a mechanistic

26 e determined for MycE bound to the product S-adenosyl-L-homocysteine (AdoHcy) and magnesium, both wit

27 trameric complex with the cofactor product S-adenosyl-l-homocysteine (AdoHcy) at 2.4 angstrom resolut

28 PRMT7 in complex with its cofactor product S-adenosyl-l-homocysteine (AdoHcy) at 2.8 A resolution and

29 hydrolase (AHCY) hydrolyzes its substrate S-adenosyl-L-homocysteine (AdoHcy) to L-homocysteine (Hcy)

30 nine (d (min) = 1.6 angstrom), the product S-adenosyl-l-homocysteine (d (min) = 1.8 angstrom), or in

31 es of human NTMT1 in complex with cofactor S-adenosyl-L-homocysteine (SAH) and six substrate peptides

32 The affinity of S-adenosyl-l-homocysteine (SAH) for SAM binding proteins w

33 e and sensitive fluorescent biosensors for S-adenosyl-l-homocysteine (SAH) that provide a direct "mix

34 HH) catalyzes the reversible conversion of S-adenosyl-L-homocysteine (SAH) to adenosine (ADO) and L-h

35 product of the methyltransferase reaction, S-adenosyl-l-homocysteine (SAH), is converted into adenine

36 uence (5'-(m7)G0pppA1G2U3U4G5U6U7-3'), and S-adenosyl-l-homocysteine (SAH), the by-product of the met

37 and the second SAM (SAM2) is converted to S-adenosyl-l-homocysteine (SAH).

38 (min) = 1.8 angstrom), or in complex with S-adenosyl-l-homocysteine and (S)-cis-N-methylstylopine (d

39 ein alpha-amine, resulting in formation of S-adenosyl-l-homocysteine and alpha-N-methylated proteins.

40 l-l-methionine (AdoMet) to glycine to form S-adenosyl-l-homocysteine and sarcosine.

41 mational state complexed with the products S-adenosyl-L-homocysteine and sinapaldehyde.

42 or the malonyl moiety and was inhibited by S-adenosyl-L-homocysteine and sinefungin.

43 with concomitant exchanges of the product S-adenosyl-l-homocysteine and the methyl donor substrate S

44 hDNMT1, residues 351-1600) in complex with S-adenosyl-l-homocysteine at 2.62A resolution.

45 associated inhibiting H3K27M peptide and a S-adenosyl-l-homocysteine cofactor.

46 nsition in the active site relative to the S-adenosyl-L-homocysteine complexes, suggesting a mechanis

47 S-Adenosyl-L-homocysteine hydrolase (AHCY) hydrolyzes its

48 S-Adenosyl-L-homocysteine hydrolase (SAHH) catalyzes the r

49 ophila homologs of the SAH hydrolase Ahcy (S-adenosyl-L-homocysteine hydrolase [SAHH[), CG9977/dAhcyL

50 anyl S-thiolodiphosphate (GSPP) along with S-adenosyl-L-homocysteine in the cofactor binding site, re

51 -linked continuous assay that converts the S-adenosyl-L-homocysteine product of DNA methylation to a

52 rK-Ser in complex with aclacinomycin T and S-adenosyl-L-homocysteine refined to 1.9-A resolution reve

53 S-Adenosyl-L-homocysteine remains bound in the active site

54 re of (s-s)MetH(CT) with cob(II)alamin and S-adenosyl-L-homocysteine represents the enzyme in the rea

55 plex with human tRNA3(Lys) and the product S-adenosyl-L-homocysteine show a dimer of heterodimers in

56 re of the ZIKV NS5 protein in complex with S-adenosyl-L-homocysteine, in which the tandem methyltrans

57 T1 in complex with its exhausted cofactor, S-adenosyl-l-homocysteine, together with mutagenesis studi

58 specific m(6)A methyltransferase, bound to S-adenosyl-L-homocysteine.

59 In this assay, S-adenosyl-l-homocystine (AdoHcy/SAH), the by-product of P

60 onsistent with its effect on the predicted S-adenosyl-l-Met binding site, dim1A plants lack the two 1

61 Here, 4-azidobut-2-enyl derivative of S-adenosyl-L-methionine (Ab-SAM) was reported as a suitabl

62 Recombinant TrmO employs S-adenosyl-L-methionine (AdoMet) as a methyl donor to meth

63 > m(7)GpppA-RNA --> m(7)GpppAm-RNA), using S-adenosyl-l-methionine (AdoMet) as a methyl donor.

64 Most of these MTases use the cofactor S-adenosyl-l-Methionine (AdoMet) as a methyl source.

65 TrmD enzymes are known to use S-adenosyl-l-methionine (AdoMet) as substrate; we have sho

66 The biological methyl donor S-adenosyl-l-methionine (AdoMet) is spontaneously degraded

67 nucleophilic attack of cytosine C5 on the S-adenosyl-L-methionine (AdoMet) methyl group is concerted

68 enase from Bacillus circulans (BtrN) is an S-adenosyl-l-methionine (AdoMet) radical enzyme.

69 substrate, catalyzes methyl transfer from S-adenosyl-l-methionine (AdoMet) to glycine to form S-aden

70 mmalian CBS is modulated by the binding of S-adenosyl-l-methionine (AdoMet) to its regulatory domain,

71 talyze the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the 5-position of cyto

72 A substrate and the methyl donor cofactor, S-adenosyl-l-methionine (AdoMet), displayed AdoMet non-com

73 For example, how both the methyl donor S-adenosyl-l-methionine (AdoMet), which is water-soluble,

74 at 1.7 A and found that it belongs to the S-adenosyl-L-methionine (AdoMet)-dependent alpha/beta-knot

75 and a regulatory C-terminal domain binding S-adenosyl-l-methionine (AdoMet).

76 d an enzyme-coupled luminescence assay for S-adenosyl-l-methionine (AdoMet/SAM)-based PMTs.

77 We describe a new metabolite, carboxy-S-adenosyl-l-methionine (Cx-SAM), its biosynthetic pathway

78 TNMT was co-crystallized with the cofactor S-adenosyl-l-methionine (d (min) = 1.6 angstrom), the prod

79 by adenosylcobalamin-dependent and radical S-adenosyl-l-methionine (RS) enzymes.

80 omposed of enzymes that reductively cleave S-adenosyl-l-methionine (SAM or AdoMet) to generate a 5'-d

81 s and is catalyzed by multiple families of S-adenosyl-L-methionine (SAM or AdoMet)-dependent methyltr

82 S-adenosyl-L-methionine (SAM) acts as a signal and binds t

83 h, specific PMTs are engineered to process S-adenosyl-L-methionine (SAM) analogs as cofactor surrogat

84 ctivity of vSET in vivo with an engineered S-adenosyl-l-methionine (SAM) analogue as methyl donor cof

85 he synthesis of an azide-bearing N-mustard S-adenosyl-L-methionine (SAM) analogue, 8-azido-5'-(diamin

86 emoenzymatic platform for the synthesis of S-adenosyl-L-methionine (SAM) analogues compatible with do

87 of CliEn-seq involves in vivo synthesis of S-adenosyl-L-methionine (SAM) analogues from cell-permeabl

88 Radical SAM (RS) enzymes use S-adenosyl-l-methionine (SAM) and a [4Fe-4S] cluster to in

89 NSD2 binds to S-adenosyl-l-methionine (SAM) and nucleosome substrates to

90 rs the enzyme inaccessible to the cofactor S-adenosyl-l-methionine (SAM) and probably to the substrat

91 nventional methyltransferases that utilize S-adenosyl-L-methionine (SAM) as a cofactor.

92 Molecular modeling and competitive S-adenosyl-l-methionine (SAM) binding assay suggest that t

93 Mutations to the S-adenosyl-l-methionine (SAM) binding motif in the nsp14 a

94 ectroscopy on the resting oxidized and the S-adenosyl-l-methionine (SAM) bound forms of pyruvate form

95 at value in the conversion of 5'-ClDA into S-adenosyl-l-methionine (SAM) but a reduced kcat value in

96 oute to biodiesel produces FAMEs by direct S-adenosyl-L-methionine (SAM) dependent methylation of fre

97 n-2 in a chemical reaction catalysed by an S-adenosyl-L-methionine (SAM) dependent Methyltransferase

98 S-adenosyl-l-methionine (SAM) dependent O-methyltransferas

99 Lysine 2,3-aminomutase (LAM) is a radical S-adenosyl-L-methionine (SAM) enzyme and, like other membe

100 DesII, a radical S-adenosyl-l-methionine (SAM) enzyme from Streptomyces ven

101 tients have mutations in MOCS1A, a radical S-adenosyl-l-methionine (SAM) enzyme involved in the conve

102 ere we demonstrate that a putative radical S-adenosyl-L-methionine (SAM) enzyme superfamily member en

103 DesII is a radical S-adenosyl-l-methionine (SAM) enzyme that can act as a dea

104 Tryptophan lyase (NosL) is a radical S-adenosyl-l-methionine (SAM) enzyme that catalyzes the fo

105 se activating enzyme (PFL-AE) is a radical S-adenosyl-l-methionine (SAM) enzyme that installs a catal

106 NifB is a radical S-adenosyl-L-methionine (SAM) enzyme that is essential for

107 Spore photoproduct lyase is a radical S-adenosyl-l-methionine (SAM) enzyme with the unusual prop

108 Viperin is predicted to be a radical S-adenosyl-l-methionine (SAM) enzyme, but it is unknown wh

109 SPL is a radical S-adenosyl-l-methionine (SAM) enzyme, which uses a [4Fe-4S

110 d by AbmJ, which is annotated as a radical S-adenosyl-l-methionine (SAM) enzyme.

111 Radical S-adenosyl-l-methionine (SAM) enzymes are widely distribut

112 Radical S-adenosyl-l-methionine (SAM) enzymes initiate biological

113 Catalysis by canonical radical S-adenosyl-l-methionine (SAM) enzymes involves electron tr

114 While the number of characterized radical S-adenosyl-l-methionine (SAM) enzymes is increasing, the r

115 The radical S-adenosyl-L-methionine (SAM) enzymes RlmN and Cfr methyla

116 Radical S-adenosyl-L-methionine (SAM) enzymes use an iron-sulfur c

117 ing isotope effects (BIEs) of the cofactor S-adenosyl-l-methionine (SAM) for SET8-catalyzed H4K20 mon

118 nsferases (MATs) catalyze the formation of S-adenosyl-l-methionine (SAM) inside living cells.

119 S-adenosyl-l-methionine (SAM) is a necessary cosubstrate f

120 S-Adenosyl-l-methionine (SAM) is recognized as an importan

121 S-Adenosyl-l-methionine (SAM) is the central cofactor in t

122 S-adenosyl-L-methionine (SAM) is the sole methyl-donor cof

123 The radical S-adenosyl-L-methionine (SAM) methyl synthases, RlmN and C

124 Many cobalamin (Cbl)-dependent radical S-adenosyl-l-methionine (SAM) methyltransferases have been

125 These results indicate that the radical S-adenosyl-L-methionine (SAM) protein PylB mediates a lysi

126 of bciD, which encodes a putative radical S-adenosyl-l-methionine (SAM) protein, are unable to synth

127 nt enzymes that are members of the radical S-adenosyl-l-methionine (SAM) superfamily was previously p

128 QueE is a member of the radical S-adenosyl-l-methionine (SAM) superfamily, all of which us

129 nslational riboswitches were identified in S-adenosyl-l-methionine (SAM) synthetase metK genes in mem

130 to cytosine (Cyt) C6, methyl transfer from S-adenosyl-l-methionine (SAM) to Cyt C5, and proton abstra

131 ate a 3-amino-3-carboxypropyl radical from S-adenosyl-L-methionine (SAM) to form a C-C bond.

132 hree cysteines in a CX(3)CX(2)C motif, and S-adenosyl-L-methionine (SAM) to generate a 5'-deoxyadenos

133 of the 3-amino-3-carboxypropyl group from S-adenosyl-l-methionine (SAM) to the histidine residue of

134 a DNA cofactor in order to stably bind to S-adenosyl-l-methionine (SAM), suggesting that it proceeds

135 S-Adenosyl-l-methionine (SAM), the primary methyl group do

136 The highly conserved S-adenosyl-l-methionine (SAM)-binding residues of the DxG

137 structures of Bud23-Trm112 in the apo and S-adenosyl-L-methionine (SAM)-bound forms.

138 Here we report a versatile S-adenosyl-l-methionine (SAM)-dependent enzyme, LepI, that

139 evealing new metalloenzymes, flavoenzymes, S-adenosyl-L-methionine (SAM)-dependent enzymes and others

140 nthesis protein NifB catalyzes the radical S-adenosyl-L-methionine (SAM)-dependent insertion of carbi

141 ic analyses predicted EftM to be a Class I S-adenosyl-l-methionine (SAM)-dependent methyltransferase.

142 gent enzyme evolution has been observed in S-adenosyl-L-methionine (SAM)-dependent methyltransferases

143 S-adenosyl-l-methionine (SAM)-dependent methyltransferases

144 ed by O-methyltransferases, members of the S-adenosyl-l-methionine (SAM)-dependent O-methyltransferas

145 elta position of the piperazyl scaffold is S-adenosyl-l-methionine (SAM)-dependent.

146 troduced methyl group is assembled from an S-adenosyl-L-methionine (SAM)-derived methylene fragment a

147 influence accumulation of the methyl donor S-adenosyl-L-methionine (SAM).

148 n known families of riboswitches that bind S-adenosyl-l-methionine (SAM).

149 e and the 3-amino-3-carboxypropyl group of S-adenosyl-l-methionine (SAM).

150 lis yitJ S-box (SAM-I) riboswitch bound to S-adenosyl-L-methionine (SAM).

151 -substrate for methyltransferase activity, S-adenosyl-l-methionine (SAM).

152 , the highly abundant methylation cofactor S-adenosyl-l-methionine (SAM).

153 yl-homoserine lactones (AHL) signals using S-adenosyl-l-methionine and either cellular acyl carrier p

154 hibitors, by mimicking each substrate, the S-adenosyl-l-methionine and the deoxycytidine, and linking

155 ng many methyltransferase enzymes that use S-adenosyl-l-methionine as a cofactor.

156 d by human S-COMT in the presence of S-[(3)H]adenosyl-l-methionine as a methyl group donor.

157 and shed light on the structural basis of S-adenosyl-L-methionine binding and methyltransferase acti

158 lone adenylation domain interrupted by the S-adenosyl-l-methionine binding region of a methyltransfer

159 for a proposed intermediate in the radical S-adenosyl-L-methionine biogenesis of the M-cluster.

160 ligands, including the first structure of S-adenosyl-l-methionine bound to a KsgA/Dim1 enzyme in a c

161 ructure of this enzyme in complex with the S-adenosyl-l-methionine cofactor at 1.7 A resolution confi

162 demonstrate that the pyruvoyl cofactor of S-adenosyl-L-methionine decarboxylase (AMD1) is dynamicall

163 S-adenosyl-l-methionine dependent methyltransferases catal

164 uration, which is catalyzed by the radical S-adenosyl-l-methionine enzyme AbmJ.

165 The radical S-adenosyl-L-methionine enzyme DesII from Streptomyces ven

166 The radical S-adenosyl-L-methionine enzyme HydG lyses free tyrosine to

167 Here we show that PhnJ is a novel radical S-adenosyl-L-methionine enzyme that catalyses C-P bond cle

168 Intriguingly, radical S-adenosyl-L-methionine enzymes are vital for the assembly

169 HydG is a member of the radical S-adenosyl-L-methionine family of enzymes that transforms

170 The radical S-adenosyl-l-methionine HydG, the best characterized of th

171 proach designed to target specifically the S-adenosyl-l-methionine pocket of catechol O-methyl transf

172 ases to provide the substrates of LipA, an S-adenosyl-L-methionine radical enzyme that inserts two su

173 Numerous cellular processes involving S-adenosyl-l-methionine result in the formation of the tox

174 The response to S-adenosyl-L-methionine stimulation or thermal activation

175 far better acceptor of methyl groups from S-adenosyl-L-methionine than was malonyl-CoA.

176 iles of PsACS [encode enzymes that convert S-adenosyl-L-methionine to 1-aminocyclopropane-1-carboxyli

177 tes HA by transferring a methyl group from S-adenosyl-l-methionine to HA, and is the only well-known

178 ecifically transfers the methyl group from S-adenosyl-L-methionine to O-4 of alpha-D-glucopyranosylur

179 alyzes the transfer of a methyl group from S-adenosyl-L-methionine to the N6 position of an adenine,

180 the transfer of the methyl group from the S-adenosyl-l-methionine to the protein alpha-amine, result

181 ansferase belongs to the diverse family of S-adenosyl-l-methionine transferases.

182 ope effects.(36)S-labeled l-methionine and S-adenosyl-l-methionine were synthesized from elemental su

183 Posttranslational methylation by S-adenosyl-L-methionine(SAM)-dependent methyltransferases

184 only compete with the enzyme cofactor SAM (S-adenosyl-L-methionine) but not the substrate nucleosome.

185 Streptomyces venezuelae is a radical SAM (S-adenosyl-l-methionine) enzyme that catalyzes the deamina

186 ransferase catalytic tetrad, interact with S-adenosyl-l-methionine, and contribute to autoguanylation

187 rom a solution of MoaA incubated with GTP, S-adenosyl-L-methionine, and sodium dithionite in the abse

188 e, resulting from in situ demethylation of S-adenosyl-L-methionine, at 2.05 or 1.82 A resolution, res

189 g the methylation site, in the presence of S-adenosyl-L-methionine, reveals a V-like protein structur

190 ncluding acupuncture, omega-3 fatty acids, S-adenosyl-L-methionine, St. John's wort [Hypericum perfor

191 rtue of the strong electrophilic nature of S-adenosyl-l-methionine, the transmethylation of the demet

192 quires a redox-active [4Fe-4S]-cluster and S-adenosyl-L-methionine, which is reductively cleaved to L

193 uA, and the methylthiolase MiaB, a radical S-adenosyl-L-methionine-dependent enzyme involved in the m

194 demonstrated that genetic deletion of the S-adenosyl-L-methionine-dependent methyltransferase from t

195 The S-adenosyl-L-methionine-dependent methyltransferase KsgA i

196 We characterized Rv0560c as an S-adenosyl-L-methionine-dependent methyltransferase that N

197 terization of a C. roseus cDNA encoding an S-adenosyl-L-methionine-dependent N methyltransferase that

198 A conserved S-adenosyl-l-methionine-dependent RNA methyltransferase, H

199 d in vitro enzyme studies identified a new S-adenosyl-l-methionine-dependent S-MT (TmtA) that is, sur

200 ification and characterization of a unique S-adenosyl-l-methionine-dependent sugar 1-O-methyltransfer

201 d in the TPsiC-loop of tRNA, from cofactor S-adenosyl-L-methionine.

202 factors, heme, pyridoxal-5'-phosphate, and S-adenosyl-l-methionine.

203 y molecular mechanism of CBS activation by S-adenosyl-l-methionine.

204 h (2.1 A) and without (2.0 A) its cofactor S-adenosyl-L-methionine.

205 exchange with a fresh molecule of cofactor S-adenosyl-L-methionine.

206 5-phosphate and methane in the presence of S-adenosyl-L-methionine.

207 hylthioguanine (S(6)mG) in the presence of S-adenosyl-l-methionine.

208 omocysteine and the methyl donor substrate S-adenosyl-l-methionine.

209 transfers a methyl group originating from S-adenosyl-l-methionine.

210 lation of H3K36 using specifically labeled S-adenosyl-l-methionine.

211 steady-state kinetics with the SAM analog Se-adenosyl-l-selenomethionine (SeAM) as a cofactor surroga

212 ort a SAM surrogate, ProSeAM (propargylic Se-adenosyl-l-selenomethionine), as a reporter of methyltra

213 genous application of ethylene precursors, S-adenosyl-Met and 1-aminocyclopropane-1-carboxylic acid,

214 ys, such as glycolysis, and the Calvin and S-adenosyl-Met cycles.

215 length and targets mRNAs encoding several S-adenosyl-Met-dependent carboxyl methyltransferase family

216 tion adjacent to the tRNA anticodon, using S-adenosyl methionine (AdoMet) as the methyl donor.

217 of genes involved in aromatic amino acid, S-adenosyl methionine (SAM) and folate biosynthetic pathwa

218 Cysteine, S-adenosyl methionine (SAM) and the formation of an iron-s

219 Colorado strains carrying mutations in the S-adenosyl methionine (SAM) binding site in the CR VI of L

220 all molecules via the in situ formation of S-adenosyl methionine (SAM) cofactor analogues is describe

221 istration of the (endogenous) methyl donor S-adenosyl methionine (SAM) did not affect CpG methylation

222 the assembly of the H cluster, the radical S-adenosyl methionine (SAM) enzyme HydG lyses the substrat

223 Additionally, we find that the cofactor S-adenosyl methionine (SAM) is necessary for stable intera

224 proliferation and increases intracellular S-adenosyl methionine (SAM) levels to feed epigenetic chan

225 based fluorescent metabolite biosensor for S-adenosyl methionine (SAM) that is expressed at low level

226 NifB utilizes two equivalents of S-adenosyl methionine (SAM) to insert a carbide atom and f

227 oordinately modulating the availability of S-adenosyl methionine (SAM), the essential metabolite for

228 e show that Red Broccoli can be fused to a S-adenosyl methionine (SAM)-binding aptamer to generate a

229 binding cleft and lacks a properly formed S-adenosyl methionine (SAM)-binding pocket necessary for n

230 S-Adenosyl methionine (SAM)-dependent C-methyltransferases

231 omolecules by a large and diverse class of S-adenosyl methionine (SAM)-dependent methyltransferases (

232 me A 3-O-methyltransferase (CCoAOMT) is an S-adenosyl methionine (SAM)-dependent O-methyltransferase

233 re, we explore the mechanism for tuning of S-adenosyl methionine (SAM)-I riboswitch folding.

234 nal switching, we constructed models of an S-adenosyl methionine (SAM)-I riboswitch RNA segment incor

235 e RNA substrate analogue and methyl donor, S-adenosyl methionine (SAM).

236 catalyze the formation of the methyl donor S-adenosyl methionine (SAM).

237 methionine, which is in turn converted to S-adenosyl methionine (SAM; the major methyl donor).

238 S-adenosyl methionine (SAMe) improves interferon signaling

239 Hepatic S-adenosyl methionine (SAMe) levels decrease in methionine

240 The use of S-adenosyl methionine (SAMe), a naturally occurring molecu

241 gars, and other small molecules, including S-adenosyl methionine and glutathione, through top-down MS

242 s conversion involves methyl transfer from S-adenosyl methionine and is critical to minimize tRNA fra

243 ession of NNMT in CAFs led to depletion of S-adenosyl methionine and reduction in histone methylation

244 synthesis requires unique enzymes that use S-adenosyl methionine as an acyl acceptor and amino acid d

245 with its histone H4 peptide substrate and S-adenosyl methionine cofactor.

246 assays demonstrated that l-methionine and S-adenosyl methionine concentrations decreased in the W7 D

247 s in mammals, but it remains unknown whether adenosyl methionine decarboxylase (AMD1), a rate-limitin

248 ith lysidine, those derived using modified S-adenosyl methionine derivatives and those using TET/JBP-

249 emonstrated by detecting the human radical S-adenosyl methionine domain containing 2 (RSAD2) gene, a

250 d enhanced expression of the IRGs, radical S-adenosyl methionine domain containing 2 and myxovirus re

251 fected cell lines showed that the internal S-adenosyl methionine domains of viperin were essential fo

252 ase) that accept analogues of the cofactor S-adenosyl methionine have been widely deployed for alkyl-

253 ase activity through changes in folate and S-adenosyl methionine metabolism.

254 Serine starvation increased the methionine/S-adenosyl methionine ratio, decreasing the transfer of me

255 Isoflavone reductase-like protein, S-adenosyl methionine synthase, and cysteine synthase isof

256 enzymes stearoyl-CoA-desaturases (SCD) and S-adenosyl methionine synthetase (sams-1) activates the UP

257 We show that the MccD enzyme uses S-adenosyl methionine to transfer 3-amino-3-carboxypropyl

258 at use different cofactors, primarily SAM (S-adenosyl methionine), NAD (nicotinamide adenine dinucleo

259 e recruitment of the methyl donor, AdoMet (S-adenosyl methionine), to RNMT.

260 is responsible for hepatic biosynthesis of S-adenosyl methionine, the principal methyl donor.

261 re vital cofactors for the regeneration of S-adenosyl methionine, which is the methyl source for DNA

262 ifying the Npl4 zinc finger domain through S-adenosyl methionine-dependent cysteine methylation.

263 thyltransferases (TMTs) might resemble the S-adenosyl methionine-dependent enzymes described for meth

264 The third largest dsRNA encodes an S-adenosyl methionine-dependent methyltransferase capping

265 hat it is a leader peptide-independent and S-adenosyl methionine-dependent O-methyltransferase that m

266 ch is known to lead to increased levels of S-adenosyl methionine-the key methyl donor for DNA methyla

267 um with a mixture of labeled and unlabeled S-adenosyl methionine.

268 ne cycle (choline: lower in AD, p = 0.003; S-adenosyl methionine: higher in AD, p = 0.005); (2) trans

269 stitution of TbtI, the responsible radical S-adenosyl-methionine (rSAM) C-methyltransferase, which ca

270 e describe the structures of RlmH bound to S-adenosyl-methionine (SAM) and the methyltransferase inhi

271 Antimorphic mutants in S-adenosyl-methionine (SAM) synthetase genes also induce t

272 Methionine generates the methyl donor S-adenosyl-methionine (SAM), which is converted via methyl

273 The knot loops form the S-adenosyl-methionine (SAM)-binding pocket as well as part

274 nosyl-homocysteine (SAH) and low levels of S-adenosyl-methionine (SAM).

275 Feeding SHC enhanced hepatic S-adenosyl-methionine and arsenic methyltransferase, where

276 Using S-adenosyl-methionine as the methyl donor, caffeic acid O-

277 mutations, we determined the apo-form and S-adenosyl-methionine binary complex SbCOMT crystal struct

278 ed with increased reactive oxygen species, S-adenosyl-methionine depletion, global hypomethylation, i

279 NtMTHFR did not affect the methionine and S-adenosyl-methionine levels in the knockdown lines.

280 the H3K9 methyltransferase Clr4 in a SAM (S-adenosyl-methionine)-dependent manner, and Clr4 is trapp

281 e, which is then used for the synthesis of S-adenosyl-methionine, a universal methyl donor for numero

282 and then placebo for 2 weeks, 65 received S-adenosyl-methionine, and 34 received no specific treatme

283 ive donor substrate of glycan methylation, S-adenosyl-methionine, from the cytoplasm to the Golgi was

284 eatment with the EZH2 inhibitor, selective S-adenosyl-methionine-competitive small-molecule (GSK126),

285 e that GSK126, a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibito

286 fication of two previously uncharacterized S-adenosyl-methionine-dependent O-methyltransferase genes,

287 anthine phosphoribosyltransferase, and the S-adenosyl-methionine-I riboswitch from the B. subtilis yi

288 ans with various assays, including in vivo S-adenosyl-[methyl-(3)H]methionine labeling, targeted in v

289 roblast growth factor receptor 2, methionine adenosyl methyltransferase 1A, and caspase 1 was validat

290 nts (Br- and N3-) can be introduced at the 8-adenosyl position of NAADP while preserving high potency

291 -position of the nicotinic acid and at the 8-adenosyl position was also recognized although the agoni

292 of initial hydrogen atom abstraction by the adenosyl radical and advances a mechanistic proposal for

293 AM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyviny

294 this reaction involving the addition of the adenosyl radical to the substrate double bond to form a

295 life, and all of these proteins generate an adenosyl radical via the homolytic cleavage of the S-C(5

296 ects on the hydrogen atom abstraction by the adenosyl radical were used to investigate the kinetic si

297 ld to generate cob(II)alamin and a transient adenosyl radical.

298 ibose C3' hydrogen atom is abstracted by the adenosyl radical.

299 ies regulate these processes: members of the adenosyl-ribosylation factor family of small G-proteins

300 ic subunit of the heterodimeric methionine S-adenosyl transferase-2 (MAT2A) with fluorinated N,N-dial