ライフサイエンスコーパス: adenosylmethionine

1 ting agents, even physiological ones (e.g. S-adenosylmethionine).

2 s, the TgCBS activity is not stimulated by S-adenosylmethionine.

3 bstrate and noncompetitive to the cofactor S-adenosylmethionine.

4 t also by the endogenous methylating agent S-adenosylmethionine.

5 detergent Triton X-100 and the methyldonor S-adenosylmethionine.

6 Stackebrandtia phosphonoglycan arise from S-adenosylmethionine.

7 th the donor methyl group of the cofactor, S-adenosylmethionine.

8 fected by intermolecular interactions with S-adenosylmethionine.

9 reactions that occur via the generation of S-adenosylmethionine.

10 e transfer of 1 deuterated methyl group to S-adenosylmethionine.

11 silon-amino group for methyl transfer with S-adenosylmethionine.

12 s a mechanism for allosteric activation by S-adenosylmethionine.

13 lysis of 5'-methylthioadenosine to salvage S-adenosylmethionine.

14 s, and 5'-methylthioadenosine recycling to S-adenosylmethionine.

15 e to a reduced conversion of methionine to S-adenosylmethionine.

16 on of tetrahydrofolate and biosynthesis of S-adenosylmethionine.

17 ersisted 1 month, whereas the methyl donor S-adenosylmethionine (500 mum) had an opposite effect on c

18 Methionine, through S-adenosylmethionine, activates a multifaceted growth prog

19 S-adenosylmethionine administration at these early stages

20 S-adenosylmethionine (AdoMet or SAM)-dependent methyltrans

21 hmt resulted in a 43% reduction in hepatic S-adenosylmethionine (AdoMet) (p < 0.01) and a 3-fold incr

22 t invariably catalyzed by enzymes that use S-adenosylmethionine (AdoMet) as the methyl group donor.

23 MoaA is a radical S-adenosylmethionine (AdoMet) enzyme that catalyzes a comp

24 phate synthase; EC 4.1.99.17) is a radical S-adenosylmethionine (AdoMet) enzyme that uses a [4Fe-4S](

25 Under anaerobic conditions, S-adenosylmethionine (AdoMet) radical chemistry is used.

26 nsertion, LipA uses a [4Fe-4S] cluster and S-adenosylmethionine (AdoMet) radical chemistry; the remai

27 oded proteins, a cobalamin (Cbl)-dependent S-adenosylmethionine (AdoMet) radical enzyme, OxsB, and an

28 The S-adenosylmethionine (AdoMet) radical superfamily of enzym

29 multiple methyltransferase domains for the S-adenosylmethionine (AdoMet) reactions.

30 ThiC is a member of the radical S-adenosylmethionine (AdoMet) superfamily and catalyzes th

31 talyze the transfer of a methyl group from S-adenosylmethionine (AdoMet) to a peptidylarginine on a p

32 talyzes the transfer of methyl groups from S-adenosylmethionine (AdoMet) to acceptor lysine residues

33 se (COMT) catalyzes a methyl transfer from S-adenosylmethionine (AdoMet) to dopamine.

34 ding enzyme-catalyzed methyl transfer from S-adenosylmethionine (AdoMet) to small-molecule catecholat

35 use MATbeta lowers the Ki of MATalpha2 for S-adenosylmethionine (AdoMet), this allowed steady-state A

36 CBS (hCBS) is allosterically activated by S-adenosylmethionine (AdoMet), which binds to the regulato

37 of methyl groups for methyltransferases is S-adenosylmethionine (AdoMet), which in most cells is synt

38 S-adenosylmethionine (AdoMet)-based methylation is integra

39 Small (>1) BIEs are observed for an S-adenosylmethionine (AdoMet)-binary and abortive ternary

40 omain lysine methyltransferases (KMTs) are S-adenosylmethionine (AdoMet)-dependent enzymes that catal

41 nvestigated METTL12, a mitochondrial human S-adenosylmethionine (AdoMet)-dependent methyltransferase

42 elegans synthesizes phosphocholine via two S-adenosylmethionine (AdoMet)-dependent phosphoethanolamin

43 PFL by the PFL-AE in a reaction requiring S-adenosylmethionine (AdoMet).

44 sensitivities to the allosteric effector, S-adenosylmethionine (AdoMet); whereas T257M and T257I are

45 I in complex with its DNA substrate and an S-adenosylmethionine analog (Sinefungin).

46 EP50 (methylosome protein 50), bound to an S-adenosylmethionine analog and a peptide substrate derive

47 balamin (coenzyme B(12)), simpler, such as S-adenosylmethionine and an iron-sulfur cluster (i.e., poo

48 thylarginine formation when incubated with S-adenosylmethionine and hypomethylated ribosomes prepared

49 itochondrial fatty-acid synthesis type II, S-adenosylmethionine and iron-sulfur clusters.

50 nd ALT levels, betaine treatment increased S-adenosylmethionine and up-regulated Dnmt3b levels, and b

51 on metabolites such as acetyl-coenzyme A, S-adenosylmethionine, and NAD+, among others.

52 cterium SAM-IV riboswitch with and without S-adenosylmethionine, and the computer-designed ATP-TTR-3

53 Ursodeoxycholic acid and S-adenosylmethionine are anti-fibrotic in bile duct ligati

54 methylating phosphatidylethanolamine using S-adenosylmethionine as a methyl donor.

55 ncentrations of the methionine metabolites S-adenosylmethionine, betaine, and cystathionine in MS gra

56 Oscillatory production of S-adenosylmethionine, betaine, choline, phosphocholine, gl

57 We found that isoleucine and S-adenosylmethionine bind to the ACT domain, negatively in

58 re dimeric with each monomer containing an S-adenosylmethionine binding domain with a core Rossmann f

59 ransferase fold, which besides the typical S-adenosylmethionine-binding site ((SAM)P) also contains a

60 lated to purine catabolism, methionine and S-adenosylmethionine biosynthesis and methionine salvage,

61 ific contributions made by thymidylate and S-adenosylmethionine biosynthesis to CRC risk.

62 ivated one-carbons between thymidylate and S-adenosylmethionine biosynthesis.

63 cate LaeA may perform novel chemistry with S-adenosylmethionine but also provide new insights into th

64 Four other metabolites, S-adenosylmethionine, carbamoyl phosphate, UDP-glucose, an

65 ter, catalyzes an enhancement of uncoupled S-adenosylmethionine cleavage relative to WT, together wit

66 crude invertebrate extracts spiked with an S-adenosylmethionine cofactor, revealing possible catalysi

67 affecting the production of decarboxylated S-adenosylmethionine (dcSAM) and polyamine synthesis.

68 ic genes encoding spermidine biosynthesis: S-adenosylmethionine decarboxylase (AdoMetDC) and spermidi

69 S-adenosylmethionine decarboxylase (AdoMetDC) catalyzes a

70 Previously we showed that trypanosomatid S-adenosylmethionine decarboxylase (AdoMetDC), a key enzym

71 Instead trypanosomatid S-adenosylmethionine decarboxylase (AdoMetDC), which catal

72 fusions of polyamine biosynthetic enzymes S-adenosylmethionine decarboxylase (AdoMetDC, speD) and am

73 of histone genes, selenoprotein genes, and S-adenosylmethionine decarboxylase (AMD1).

74 In the present study, S-adenosylmethionine decarboxylase (SAMDC), a key gene inv

75 Among the new tumour suppressors are adenosylmethionine decarboxylase 1 (AMD1) and eukaryotic

76 stems from mTORC1-dependent regulation of S-adenosylmethionine decarboxylase 1 (AMD1) stability.

77 ort X-ray structures of Trypanosoma brucei S-adenosylmethionine decarboxylase alone and in functional

78 trescine amidohydrolase in archaea, and of S-adenosylmethionine decarboxylase and ornithine decarboxy

79 zone (MGBG), a polyamine analog and potent S-adenosylmethionine decarboxylase inhibitor, decreases HI

80 hyltetrahydrofolate:Hcy methyltransferase, S-adenosylmethionine decarboxylase, DNA methyltransferase

81 anosomatid spermidine biosynthetic enzyme, S-adenosylmethionine decarboxylase, is regulated by hetero

82 imental frameshift frequencies measured in S-adenosylmethionine-decarboxylase and antizyme mutants, a

83 ll living organisms, mostly relies on SAM (S-adenosylmethionine)-dependent methyltransferases.

84 factor, revealing possible catalysis by an S-adenosylmethionine-dependent carboxylic acid methyltrans

85 ular adenosine mediated by modification of S-adenosylmethionine-dependent DNA methylation.

86 S-Adenosylmethionine-dependent DNA methyltransferases (MTa

87 recent evidence supporting a role for the S-adenosylmethionine-dependent enzyme NifB in the incorpor

88 thylation of lysine residues, catalyzed by S-adenosylmethionine-dependent lysine methyltransferases (

89 identify a previously undescribed class of S-adenosylmethionine-dependent methylases that convert a p

90 We present a selection design that couples S-adenosylmethionine-dependent methylation to growth.

91 provide in vivo evidence that a dedicated S-adenosylmethionine-dependent methyltransferase encoded b

92 ATP binding region-containing proteins and S-adenosylmethionine-dependent methyltransferase proteins.

93 deazaneplanocin A (DZNep), an inhibitor of S-adenosylmethionine-dependent methyltransferase that targ

94 hanocaldococcus jannaschii encodes a novel S-adenosylmethionine-dependent methyltransferase, now iden

95 7, is predicted to belong to the family of S-adenosylmethionine-dependent methyltransferases characte

96 belongs to the family of seven-beta-strand S-adenosylmethionine-dependent methyltransferases.

97 Phosphatidylcholine (PC) produced via the S-adenosylmethionine-dependent phosphatidylethanolamine (P

98 one-carbon metabolism due to their common S-adenosylmethionine-dependent transmethylation and has im

99 and transposon derepression indicate that S-adenosylmethionine-dependent transmethylation is inhibit

100 -linked peptide formed by MftC through two S-adenosylmethionine-dependent turnovers.

101 PqqE, a radical S-adenosylmethionine enzyme in pyrroloquinoline quinone (P

102 Here we demonstrate that BzaF is a radical S-adenosylmethionine enzyme that catalyzes the remarkable

103 MoaA, a radical S-adenosylmethionine enzyme, catalyzes the first step in m

104 It is repaired by a radical SAM (S-adenosylmethionine) enzyme, the spore photoproduct lyase

105 cessory proteins, two of which are radical S-adenosylmethionine enzymes (HydE, HydG) and one of which

106 emical characterization of these 8 radical S-adenosylmethionine enzymes and, in the context of human

107 n this minireview, we describe the radical S-adenosylmethionine enzymes involved in the biosynthesis

108 ba57p, which aconitase and certain radical S-adenosylmethionine enzymes require for activity.

109 current state of knowledge of the radical S-adenosylmethionine enzymes required for synthesis of the

110 HydE and HydG are radical S-adenosylmethionine enzymes that chemically modify a H-cl

111 (2)-sensitive [4Fe-4S] clusters in radical S-adenosylmethionine enzymes.

112 , two of which (HydE and HydG) are radical S-adenosylmethionine enzymes.

113 ions with the AMMECR1 domain and a radical S-adenosylmethionine family domain.

114 ose and 2,6-diaminopurine produced 2-amino-S-adenosylmethionine for hydrolytic conversion to 2AMTA.

115 nine (SAM) enzyme that reductively cleaves S-adenosylmethionine, generating 5'-deoxyadenosyl radicals

116 rine-glycine-one-carbon pathway coupled to S-adenosylmethionine generation.

117 affecting essential pathways that utilize S-adenosylmethionine in addition to methionine.

118 r that the enzyme converting methionine to S-adenosylmethionine in mESCs, methionine adenosyltransfer

119 produces 5-methylthioadenosine (MTA) from S-adenosylmethionine in polyamine biosynthesis; however, R

120 hyl incorporation of radioactively labeled S-adenosylmethionine into recombinant fragments of OmpB.

121 S-Adenosylmethionine is widely used in a variety of biolog

122 ty (KD of 0.14-2.2 muM) than the substrate S-adenosylmethionine (KD of 22-43 muM), which indicates pr

123 ficiency, as demonstrated by reductions in S-adenosylmethionine levels and in global DNA methylation.

124 Huh7 cells overexpressing MAT1A had higher S-adenosylmethionine levels but lower bromodeoxyuridine in

125 rotein and methylation potential [ratio of S-adenosylmethionine (major methyl donor):S-adenosylhomocy

126 onate breakdown pathway and the methionine/S-adenosylmethionine (Met/SAM) cycle.

127 SAH catabolism is linked to S-adenosylmethionine metabolism, and the development of SA

128 er choline, which can serve as a source of S-adenosylmethionine methyl groups, influences PC-DHA or t

129 sp. CX-1, and identified a gene encoding a S-adenosylmethionine methyltranserase termed BlArsM with l

130 ion can be mediated by the enzyme arsenite S-adenosylmethionine methyltransferase (ArsM) or through t

131 catalyzed by the enzyme arsenite (As[III]) S-adenosylmethionine methyltransferase (ArsM).

132 lts suggest that BlArsM is a novel As(III) S-adenosylmethionine methyltransferase requiring only two

133 lly, we demonstrate that ChuW is a radical S-adenosylmethionine methyltransferase that catalyzes a ra

134 We found that binding by the cofactor S-adenosylmethionine mitigates this autoinhibited structur

135 responsive to the known modulators of CBS: S-adenosylmethionine, NO, and CO.

136 apo form and in complex with its cofactor S-adenosylmethionine or S-adenosylhomocysteine.

137 s monomeric in the absence and presence of S-adenosylmethionine or S-adenosylhomocysteine.

138 factocin biosynthesis is one example of an S-adenosylmethionine protein-dependent RiPP pathway.

139 ubset of these pathways depends on radical S-adenosylmethionine proteins to modify the RiPP-produced

140 s acidocaldarius Both proteins are radical S-adenosylmethionine proteins, indicating that GDGT cycliz

141 rum sensing and encode one or more radical S-adenosylmethionine (RaS) enzymes, a diverse protein supe

142 es (RiPPs) and contain one or more radical S-adenosylmethionine (RaS) enzymes, a versatile superfamil

143 (RiPPs) that contain at least one radical S-adenosylmethionine (RaS) metalloenzyme and are regulated

144 ontain one or more uncharacterized radical S-adenosylmethionine (RaS) metalloenzymes.

145 oxal 5'-phosphate (PLP) for catalysis, and S-adenosylmethionine regulates the activity of human CBS,

146 ed methyl cycle (AMC), which generates the S-adenosylmethionine required by methyltransferases and re

147 three putative cobalamin-dependent radical S-adenosylmethionine (RS) enzymes, ThnK, ThnL, and ThnP, a

148 Radical S-adenosylmethionine (RS) enzymology has emerged as a majo

149 PqqE is a radical S-adenosylmethionine (RS) protein with a C-terminal SPASM

150 ed to be catalyzed by two putative radical S-adenosylmethionine (rSAM) enzymes, PoyB and PoyC.

151 overy of four different classes of radical S-adenosylmethionine (rSAM) methyltransferases that methyl

152 cid were dose-dependently increased, while S-adenosylmethionine, S-adenosylhomocysteine, and cystathi

153 S-Adenosylmethionine, S-adenosylhomocysteine, S-ribosylhom

154 cystathionine (P<0.01), and the decreased S-adenosylmethionine/S-adenosyl homocysteine ratio (P<0.01

155 This was associated with a higher S-adenosylmethionine/S-adenosylhomocysteine ratio and lowe

156 A decreased S-adenosylmethionine: S-adenosylhomocysteine ratio and inc

157 C availability, methylation potential (the S-adenosylmethionine: S-adenosylhomocysteine ratio) in the

158 Radical S-adenosylmethionine (SAM) (RS) methylases perform methyla

159 IKV NS5 methyltransferase bound to a novel S-adenosylmethionine (SAM) analog in which a 4-fluoropheny

160 levels of which are reliant upon adequate S-adenosylmethionine (SAM) and inhibited by S-adenosylhomo

161 levels of methionine and the methyl donor S-adenosylmethionine (SAM) and resulting in loss of dimeth

162 arbide originates from the methyl group of S-adenosylmethionine (SAM) and that it is inserted into th

163 Protein methyltransferases require S-adenosylmethionine (SAM) as a co-factor (methyl donor) f

164 methylates nicotinamide (vitamin B3) using S-adenosylmethionine (SAM) as a methyl donor.

165 ite (rVSV-K1651A, -D1762A, and -E1833Q) or S-adenosylmethionine (SAM) binding site (rVSV-G1670A, -G16

166 ecombinant hMPVs carrying mutations in the S-adenosylmethionine (SAM) binding site in CR VI of L prot

167 The nutrient-sensing metabolite S-adenosylmethionine (SAM) controls one-carbon metabolism

168 ly days, radical enzyme reactions that use S-adenosylmethionine (SAM) coordinated to an Fe-S cluster,

169 velopment and fertility via the methionine/S-Adenosylmethionine (SAM) cycle and breaks down the short

170 (Mat1a) knockout (KO) mice express hepatic S-adenosylmethionine (SAM) deficiency and increased ERK ac

171 The studies revealed GilMT as a typical S-adenosylmethionine (SAM) dependent O-methyltransferase,

172 We found that the methyl donor S-adenosylmethionine (SAM) disrupts the SAMTOR-GATOR1 comp

173 iviral protein that belongs to the radical S-adenosylmethionine (SAM) enzyme family.

174 The radical S-adenosylmethionine (SAM) enzyme HydG lyses free l-tyrosi

175 koshii Dph2 (PhDph2) is an unusual radical S-adenosylmethionine (SAM) enzyme involved in the first st

176 The radical S-adenosylmethionine (SAM) enzyme NifB occupies a central

177 tigation of the incredibly diverse radical S-adenosylmethionine (SAM) enzyme superfamily, PPP aided i

178 DesII is a radical S-adenosylmethionine (SAM) enzyme that catalyzes the C4-de

179 Viperin is an IFN-inducible radical S-adenosylmethionine (SAM) enzyme that inhibits viral repl

180 Biotin synthase is a radical S-adenosylmethionine (SAM) enzyme that reductively cleaves

181 TsrM, an annotated radical S-adenosylmethionine (SAM) enzyme, catalyzes the methylati

182 AprD4 is shown to be a radical S-adenosylmethionine (SAM) enzyme, catalyzing homolysis of

183 ss-link, which is installed by the radical S-adenosylmethionine (SAM) enzyme, StrB.

184 SPL is a radical S-adenosylmethionine (SAM) enzyme, utilizing the 5'-deoxya

185 Radical S-adenosylmethionine (SAM) enzymes account for nearly 2% o

186 Radical S-adenosylmethionine (SAM) enzymes are emerging as a major

187 e and is a member of a subclass of radical S-adenosylmethionine (SAM) enzymes called radical SAM (RS)

188 Radical S-adenosylmethionine (SAM) enzymes catalyze an astonishing

189 Radical S-adenosylmethionine (SAM) enzymes exist in organisms from

190 RimO and MiaB are radical S-adenosylmethionine (SAM) enzymes that catalyze the attac

191 he sactipeptide RiPP class via the radical S-adenosylmethionine (SAM) enzymes that form the character

192 Radical S-adenosylmethionine (SAM) enzymes use a [4Fe-4S] cluster

193 Radical S-adenosylmethionine (SAM) enzymes use a [4Fe-4S] cluster

194 Radical S-adenosylmethionine (SAM) enzymes use the oxidizing power

195 We determined two radical S-adenosylmethionine (SAM) enzymes, one each from an SNP g

196 In radical S-adenosylmethionine (SAM) enzymes, the 5'-dAdo* is formed

197 embly scaffolds by the activity of radical S-adenosylmethionine (SAM) enzymes.

198 s been shown to be a member of the radical S-adenosylmethionine (SAM) family of enzymes, [4Fe-4S] clu

199 sferase (MAT2A) catalyzes the formation of S-adenosylmethionine (SAM) from ATP and methionine.

200 nance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for a wide variety

201 The methyl donor S-adenosylmethionine (SAM) is produced in most cells throu

202 S-adenosylmethionine (SAM) is the methyl donor for biologi

203 S-adenosylmethionine (SAM) is the methyl-donor substrate f

204 on, Hcy, S-adenosylhomocysteine (SAH), and S-adenosylmethionine (SAM) levels, and SAM/SAH ratios in m

205 ranslational level in response to cellular S-adenosylmethionine (SAM) levels.

206 e sulfur metabolism through binding to the S-adenosylmethionine (SAM) ligand and offer compelling tar

207 mily of proteins that perform both radical-S-adenosylmethionine (SAM) mediated sulfur insertion and S

208 We found that threonine and S-adenosylmethionine (SAM) metabolism are coupled in pluri

209 ational changes upon Mg(2+) compaction and S-adenosylmethionine (SAM) metabolite binding.

210 NosN is annotated as a class C radical S-adenosylmethionine (SAM) methylase, but its true functio

211 how that NosN, a predicted class C radical S-adenosylmethionine (SAM) methylase, catalyzes both the t

212 sion of the arsM gene encoding the As(III) S-adenosylmethionine (SAM) methyltransfase from Rhodopseud

213 using CysS, a cobalamin-dependent radical S-adenosylmethionine (SAM) methyltransferase.

214 of the arsM gene that encodes the As(III) S-adenosylmethionine (SAM) methyltransferase.

215 Cobalamin (Cbl)-dependent radical S-adenosylmethionine (SAM) methyltransferases catalyze met

216 Members of every kingdom have ArsM As(III) S-adenosylmethionine (SAM) methyltransferases that methyla

217 s of a methyl group partially derived from S-adenosylmethionine (SAM) onto electrophilic sp(2)-hybrid

218 domains in apo form as well as with bound S-adenosylmethionine (SAM) or S-adenosylhomocysteine (SAH)

219 nd biochemically characterized the radical S-adenosylmethionine (SAM) protein MaMmp10, the product of

220 The radical S-adenosylmethionine (SAM) protein PqqE is predicted to fu

221 LipA is a member of the radical S-adenosylmethionine (SAM) superfamily of enzymes and uses

222 TsrM is a member of the radical S-adenosylmethionine (SAM) superfamily of enzymes, but it

223 RimO is a member of the growing radical S-adenosylmethionine (SAM) superfamily of enzymes, which u

224 panding subgroup of enzymes of the radical S-adenosylmethionine (SAM) superfamily that harbor one or

225 ductase (MTHFR) provides methyl donors for S-adenosylmethionine (SAM) synthesis and methylation react

226 of the liver-specific MAT1A gene, encoding S-adenosylmethionine (SAM) synthesizing isozymes MATI/III,

227 It transfers the methyl group of S-adenosylmethionine (SAM) to catalyze the synthesis of ep

228 ial [4Fe-4S] cluster to reductively cleave S-adenosylmethionine (SAM) to generate a reactive 5'-dA ra

229 t anaerobic end, enzymes reversibly cleave S-adenosylmethionine (SAM) to generate the 5'-deoxyadenosy

230 alyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to glycine generating S-adenosy

231 the [4Fe-4S](+) cluster to the coordinated S-adenosylmethionine (SAM) to induce homolytic S-C5' bond

232 lyze the transfer of the methyl group from S-adenosylmethionine (SAM) to lysine residues in histone t

233 fundamental bacterial metabolic pathways: S-adenosylmethionine (SAM) utilization, polyamine biosynth

234 spiration from Nature's methylating agent, S-adenosylmethionine (SAM), allowed for the design and dev

235 PBMC DNA methylation, plasma folate, blood S-adenosylmethionine (SAM), and concentrations of As in dr

236 betaine, S-adenosylhomocysteine (SAH), and S-adenosylmethionine (SAM), and higher percentages of men

237 llular concentrations of the methyl donor, S-adenosylmethionine (SAM), and increasing the demethylate

238 phosphocholine cytidylyltransferase (PCT), S-adenosylmethionine (SAM), and S-adenosylhomocysteine (SA

239 y extensive interactions with the cofactor S-adenosylmethionine (SAM), conferring SAM-dependent subst

240 Here we review the roles of acetyl-CoA and S-adenosylmethionine (SAM), donor substrates for acetylati

241 e nutrients, S-adenosylhomocysteine (SAH), S-adenosylmethionine (SAM), homocysteine, cysteine, and di

242 en known to be allosterically inhibited by S-adenosylmethionine (SAM), only relatively recently has N

243 oswitch, one of several classes that binds S-adenosylmethionine (SAM), represses translation upon bin

244 Met is the obligate precursor of S-adenosylmethionine (SAM), the methyl donor utilized by a

245 eno-pyrimidones that were competitive with S-adenosylmethionine (SAM), the physiological methyl donor

246 p10 heterodimers bound to the methyl donor S-adenosylmethionine (SAM), the reaction product S-adenosy

247 1p represses genes that maintain levels of S-adenosylmethionine (SAM), the substrate for most methylt

248 f this pathway, is the direct precursor of S-adenosylmethionine (SAM), the universal methyl donor nee

249 expression of SIN3 leads to an increase in S-adenosylmethionine (SAM), which is the major cellular do

250 id methionine is a metabolic precursor for S-adenosylmethionine (SAM), which serves as a coenzyme for

251 sidues in histone proteins is catalyzed by S-adenosylmethionine (SAM)-dependent histone lysine methyl

252 pends on the integrity of the helicase and S-adenosylmethionine (SAM)-dependent methyltransferase-lik

253 S-Adenosylmethionine (SAM)-dependent methyltransferases ar

254 SAH is a potent feedback inhibitor of S-adenosylmethionine (SAM)-dependent methyltransferases th

255 programming and is most often achieved by S-adenosylmethionine (SAM)-dependent methyltransferases.

256 nd oxygenation through the action of eight S-adenosylmethionine (SAM)-dependent mycolic acid methyltr

257 Several members of a distinct family of S-adenosylmethionine (SAM)-dependent N-methyltransferases

258 LepI is an S-adenosylmethionine (SAM)-dependent pericyclase that cata

259 The S-adenosylmethionine (SAM)-I riboswitch is a noncoding RNA

260 sing almost exclusively upon Mg(2+) and/or S-adenosylmethionine (SAM)-induced folding of full-length

261 The S(MK) (SAM-III) box is an S-adenosylmethionine (SAM)-responsive riboswitch found in

262 purified enzyme contains internally-bound S-adenosylmethionine (SAM).

263 nine boosts synthesis of the methyl donor, S-adenosylmethionine (SAM).

264 thylates nicotinamide (NAM) using cofactor S-adenosylmethionine (SAM).

265 cilitate the unusual acyl conjugation with S-adenosylmethionine (SAM).

266 S-Adenosylmethionine (SAM, also known as AdoMet) radical e

267 ich have chronically low levels of hepatic S-adenosylmethionine (SAMe) and spontaneously develop stea

268 are the primary genes involved in hepatic S-adenosylmethionine (SAMe) synthesis and degradation, res

269 The principal methyl donor of the cell, S-adenosylmethionine (SAMe), is produced by the highly con

270 were found for replicated studies testing S-adenosylmethionine (SAMe), methylfolate, omega-3 (primar

271 ine N-methyltransferase (GNMT) catabolizes S-adenosylmethionine (SAMe), the main methyl donor of the

272 e in peripheral nerve myelination and that S-adenosylmethionine (SAMe), the principal methyl donor in

273 S-Adenosylmethionine (SAMe), the principal methyl donor th

274 ransferase (MAT) catalyzes biosynthesis of S-adenosylmethionine (SAMe), the principle methyl donor.

275 heir liver tissues have abnormal levels of S-adenosylmethionine (SAMe).

276 bon cycle, which produces the methyl donor S-adenosylmethionine (SAMe).

277 id pathway, we excluded a toxic effect of Se-adenosylmethionine, Se-adenosylhomocysteine, or of any c

278 nt uncovered a nitrogen-, methionine-, and S-adenosylmethionine-sufficiency response, resulting in re

279 methylsynthases that belong to the radical S-adenosylmethionine superfamily of enzymes.

280 n of worm methionine synthase (metr-1) and S-adenosylmethionine synthase (sams-1) imply metformin-ind

281 onine synthase; inactivation of the sams-1 S-adenosylmethionine synthase also suppresses the drp-1 fi

282 istones, is synthesized from methionine by S-adenosylmethionine synthase; inactivation of the sams-1

283 ins have diverse cellular roles, including S-adenosylmethionine synthesis, respiration, and host tran

284 zymes central to all cellular methylation, S-adenosylmethionine synthetase and S-adenosylhomocysteine

285 is (Arabidopsis thaliana), one of the four S-adenosylmethionine synthetase genes, METHIONINE ADENOSYL

286 Interestingly, although metK (encoding S-adenosylmethionine synthetase) was essential in vitro, i

287 ch contains serine metabolic enzymes, SAM (S-adenosylmethionine) synthetases, and an acetyl-CoA synth

288 S-adenosylmethionine, the methyl donor of many methylation

289 ovo synthesis of purines, thymidylate, and S-adenosylmethionine, the primary cellular methyl donor.

290 ansferase (MAT) catalyzes the synthesis of S-adenosylmethionine, the principal methyl donor, and is e

291 (3-MeA) is formed in DNA by reaction with S-adenosylmethionine, the reactive methyl donor, and by re

292 been found to catalyze alkyl transfer from S-adenosylmethionine to halide ions.

293 The enzyme utilizes S-adenosylmethionine to methylate a variety of phosphonate

294 yzes the methyl transfer from the cofactor S-adenosylmethionine to nicotinamide and other pyridine-co

295 by a typical Sn2-type methyl transfer from S-adenosylmethionine to pEA.

296 f GSH to oxidized forms of glutathione and S-adenosylmethionine to S-adenosylhomocysteine levels, res

297 r of donor methyl groups from the cofactor S-adenosylmethionine to specific acceptor lysine residues

298 tracellular concentration of methionine or S-adenosylmethionine was increased.

299 euterated 5'-deoxyadenosine and deuterated S-adenosylmethionine when the reaction is carried out in D

300 Addition of NTPs, Mg(2+), and S-adenosylmethionine, which allows active transcription, r