ライフサイエンスコーパス: adenylate

1 Thr) and non-hydrolyzable analog of threonyl adenylate.

2 related antibiotics are Trojan-horse peptide-adenylates.

3 way for preparation of more potent peptidyl-adenylates.

4 and various toxic nonhydrolyzable aminoacyl adenylates.

5 We show that ligases generate adenylated 5' ends containing a ribose characteristic of

6 g the abortive ligation product, i.e. the 5'-adenylate (5'-AMP) group, during DNA replication and rep

7 that produces chemically adducted, toxic 5'-adenylated (5'-AMP) DNA lesions.

8 n events in eukaryotic cells can generate 5'-adenylated (5'-AMP) DNA termini that can be removed from

9 While pre-adenylated adapters can be chemically or enzymatically p

10 ofiling assays is adapter ligation using pre-adenylated adapters.

11 in vivo by a resveratrol-displacing tyrosyl adenylate analogue.

12 l-tRNA synthetases in complex with aminoacyl adenylate analogues and applied a structure-based drug d

13 zymes that function maintaining the cellular adenylate and guanylate nucleotide.

14 ry mechanism for balancing the intracellular adenylate and guanylate pools.

15 e that nsp8 has a pronounced specificity for adenylate and is unable to incorporate guanylate into RN

16 activation of the salicylic acid as an acyl-adenylate and ligation onto the acyl carrier protein (AC

17 Adenylated and uridylated forms of these RNAs accumulate

18 that mRNAs entering the editing pathway are adenylated and, therefore, competent for post-editing A/

19 tionships and inhibition mechanisms by alkyl adenylates and diarylated coumarins.

20 Firefly luciferase adenylates and oxidizes d-luciferin to chemically genera

21 syl-pantetheine conjugate is phosphorylated, adenylated, and phosphorylated once more to generate a f

22 tted element H4a/Psi3 required five upstream adenylates, and H4a/Psi3 was necessary for cooperative a

23 Microcin C is a heptapeptide-adenylate antibiotic produced by some strains of Escheri

24 unit in the complex with an analog of glycyl adenylate at 2.8 A resolution presents a conformational

25 here find that maternal microRNAs are highly adenylated at their 3' ends in mature oocytes and early

26 particularly sensitive to inhibition by the adenylates, ATP and ADP.

27 N1 also failed to provide excision of the 5'-adenylated BER intermediate in mitochondrial extracts.

28 pter at ~100% efficiency and can efficiently adenylate both DNA and RNA bases.

29 o detoxify several nonhydrolyzable aminoacyl adenylates but not processed McC.

30 in the activated state, with a cyclic tetra-adenylate (cA(4)) molecule bound at the core of the prot

31 III systems and that Csx3 binds cyclic tetra-adenylate (cA(4)) second messenger with high affinity.

32 III-D CRISPR complex generates cyclic tetra-adenylate (cA(4)), activating the ribonuclease Csx1, and

33 nuclease that rapidly degrades cyclic tetra-adenylate (cA(4)).

34 r) enzymes that rapidly degrade cyclic tetra-adenylate (cA(4)).

35 clease enzyme (Crn1) to degrade cyclic tetra-adenylate (cA4) and deactivate the ancillary nucleases.

36 be achieved predominantly via a cyclic hexa-adenylate (cA6) signalling pathway and the ribonuclease

37 selectivity of the three most commonly used adenylate cyclase (AC) inhibitors in a battery of cell l

38 Adenylate cyclase (AC) is an attractive candidate as a p

39 PC12 cells express five adenylate cyclase (AC) isoforms, most abundantly AC6 and

40 vate phosphotransferase system (PEP-PTS) and adenylate cyclase (AC) IV (encoded by BB0723 [cyaB]) are

41 ects using soluble guanylyl cyclase (sGC) or adenylate cyclase (AC) specific inhibitors.

42 The adenylate cyclase (CyaA) toxin, a multidomain protein of

43 We show that Snf1 and adenylate cyclase (Cyr1) interact in a nutrient-independ

44 We found that a di-adenylate cyclase (disA or dacA)-overexpressing M. tuber

45 cAMP source in the flagellum is the soluble adenylate cyclase (SACY).

46 nd the G protein-coupled receptor --> Gs --> adenylate cyclase --> cAMP --> neuritogenic cAMP sensor-

47 om the G protein-coupled receptor --> Gs --> adenylate cyclase --> cAMP --> PKA --> cAMP response ele

48 sense mutation c.3112C>T (p.Arg1038*) within adenylate cyclase 1 (ADCY1) was identified.

49 Three SNPs within adenylate cyclase 2 (ADCY2) showed the same direction of

50 Adenylate cyclase 3 (Adcy3) has been shown to colocalize

51 Adenylate cyclase 5 catalyzes the production of cyclic A

52 hisms (SNPs) within the ADCY5 gene, encoding adenylate cyclase 5, are associated with elevated fastin

53 ide in introns of ADCY5, a gene that encodes adenylate cyclase 5.

54 a previously unrecognized connection between adenylate cyclase 6 (AC6), a cilia signaling mediator, a

55 Here, we report that adenylate cyclase 6 (AC6), a highly abundant AC isoform

56 e silencing of Bicc1 target mRNAs, including adenylate cyclase 6 (AC6).

57 ancer: stromal cell-derived factor 1 (SDF1), adenylate cyclase 7 (ADCY7), and p21 protein-activated k

58 orphisms in the human adenylate cyclase gene adenylate cyclase 8 (ADCY8) that correlate with glioma r

59 ociated with known (TSHR, GNAS) or presumed (adenylate cyclase 9 [ADCY9]) alterations in cAMP pathway

60 on cardiovascular outcomes are determined by adenylate cyclase 9 gene polymorphisms.

61 genotyped for the rs1967309 polymorphism in adenylate cyclase 9.

62 However, both inhibition of adenylate cyclase A (ACA) with SQ22536 and incubation of

63 ompression, with ADCYAP1 (encoding pituitary adenylate cyclase activating peptide, PACAP) being the m

64 S) has been shown to increase BNST pituitary adenylate cyclase activating polypeptide (PACAP) and its

65 recent evidence has suggested that pituitary adenylate cyclase activating polypeptide (PACAP) has cri

66 Pituitary adenylate cyclase activating polypeptide (PACAP) is an e

67 Pituitary adenylate cyclase activating polypeptide (PACAP, gene Ad

68 rphism in the PACAP receptor gene ADCYAP1R1, adenylate cyclase activating polypeptide 1 receptor type

69 tionarily conserved neuropeptides, including adenylate cyclase activating polypeptide 1b (adcyap1b),

70 ave reported that the neuropeptide pituitary adenylate cyclase activating polypeptide 38 (PACAP38) al

71 he type I receptor (PAC1-R) of the pituitary adenylate cyclase activating polypeptide has been report

72 the effects of blocking glutamate, pituitary adenylate cyclase activating polypeptide, and microglia

73 Chemicals, such as glutamate and pituitary adenylate cyclase activating polypeptide, whose expressi

74 m these progenitors transform in response to adenylate cyclase activation from being UCP1 negative to

75 agents, melanocortin 1 receptor activators, adenylate cyclase activators, phosphodiesterase 4D3 inhi

76 of cAMP on Fe(II) and 5hmC was confirmed by adenylate cyclase activators, phosphodiesterase inhibito

77 the valence in DRD mice with an increase in adenylate cyclase activity and blunted behavioural respo

78 marily couples to G(i/o) proteins to inhibit adenylate cyclase activity and typically induces downstr

79 biogenesis is based on the reconstitution of adenylate cyclase activity from a split enzyme.

80 tion results via bidirectional modulation of adenylate cyclase activity in presynaptic glutamatergic

81 (a putative cyaB homolog) was shown to have adenylate cyclase activity in vitro; however, mutants wi

82 udomonas aeruginosa ExoY was shown to confer adenylate cyclase activity on the MARTX toxin.

83 , D1-dopamine receptors were supersensitive; adenylate cyclase activity, locomotor activity and stere

84 nal processes, such as protein synthesis and adenylate cyclase activity, through protein-protein inte

85 In the MB, Rutabaga (Rut) adenylate cyclase acts as a coincidence detector during

86 ns in Caenorhabditis elegans, the engineered adenylate cyclase affected worm behavior in a light-depe

87 mechanism is mediated through activation of adenylate cyclase and an increase of cAMP and intracellu

88 atory effects of the PEP-PTS are mediated by adenylate cyclase and cyclic AMP (cAMP) levels.

89 n the distal renal tubule), possibly through adenylate cyclase and cyclic AMP signaling and a cytopla

90 a synthetic OR14I1 peptide and inhibitors of adenylate cyclase and protein kinase A (PKA) signaling.

91 nel coupling, and CB1-mediated inhibition of adenylate cyclase and protein kinase A activity.

92 imimetics promote CFTR opening by activating adenylate cyclase and we show that Ca(2+)-stimulated typ

93 otein kinase (AMPK) via direct inhibition of adenylate cyclase by AMP.

94 Blockade of adenylate cyclase by its inhibitor reversed PGE2-mediate

95 8 integrin and on delivery of its N-terminal adenylate cyclase catalytic domain (AC domain) into the

96 phaeroides bacteriophytochrome BphG1 and the adenylate cyclase domain from Nostoc sp. CyaB1.

97 Based on the discovery that the adenylate cyclase from Bordetella pertussis binds to the

98 n of the amino acid sequences of globins and adenylate cyclase from prokaryotic to eukaryotic organis

99 its stalk by expression of a light-activated adenylate cyclase from the ACA promoter and exposure to

100 we report genetic polymorphisms in the human adenylate cyclase gene adenylate cyclase 8 (ADCY8) that

101 y encode TFP, the Chp system, FimL, FimV and adenylate cyclase homologs, suggesting that surface sens

102 trafficking of olfactory signaling proteins, adenylate cyclase III (ACIII), and cyclic nucleotide-gat

103 , as we were unable to identify a functional adenylate cyclase in S. aureus and only detected 2',3'-c

104 nteracted with the RAS-binding domain of the adenylate cyclase in vitro, and the cAMP analogue 8-brom

105 se effects are reduced in the presence of an adenylate cyclase inhibitor, yet persist in the presence

106 zed by pretreatment with protein kinase A or adenylate cyclase inhibitors, H89 and di-deoxyadenosine,

107 se and we show that Ca(2+)-stimulated type I adenylate cyclase is expressed in the developing human l

108 Because adenylate cyclase is only functional in the cytoplasm, b

109 ase of intracellular cAMP by an activator of adenylate cyclase or an analog of cAMP, or a blockade of

110 ellular cAMP and activate PKA (activators of adenylate cyclase or inhibitors of phosphodiesterase 4)

111 y develop alternative strategies to activate adenylate cyclase signalling in multiple cancer types.

112 enetic strategy that uses a photoactivatable adenylate cyclase to achieve real-time regulation of cAM

113 Adenylate cyclase toxin (ACT or CyaA) plays a crucial ro

114 Adenylate cyclase toxin (ACT) is a critical factor in es

115 The adenylate cyclase toxin (ACT) is a multifunctional virul

116 with Bordetella pertussis, and the secreted adenylate cyclase toxin (ACT) is essential for the bacte

117 The adenylate cyclase toxin (ACT) of Bordetella pertussis in

118 B. pertussis uses pertussis toxin (PT) and adenylate cyclase toxin (ACT) to kill and modulate host

119 ent of whooping cough, secretes and releases adenylate cyclase toxin (ACT), which is a protein bacter

120 Here we found that the adenylate cyclase toxin (CyaA), a key virulence factor o

121 overn the activities of Bordetella pertussis adenylate cyclase toxin (CyaA), Escherichia coli alpha-h

122 ine with the finding that antibodies against adenylate cyclase toxin were only elicited by BPZE1.CONC

123 The Bordetella adenylate cyclase toxin-hemolysin (CyaA) and the alpha-h

124 The adenylate cyclase toxin-hemolysin (CyaA) plays a key rol

125 The adenylate cyclase toxin-hemolysin (CyaA) plays a key rol

126 Adenylate cyclase translocation assays revealed 13 prote

127 Here we utilized the bacterial adenylate cyclase two-hybrid method and carried out a sa

128 ta1AR signal transduction cascade, including adenylate cyclase VI and the catalytic subunit of the cA

129 nesis of one of these fusions resulted in an adenylate cyclase with a sixfold photodynamic range.

130 Stimulation of endogenous adenylate cyclase with forskolin or inhibition of phosph

131 rs to translocate LF (a protease) and EF (an adenylate cyclase) into cells.

132 e counterpart, human RPS23RG1 interacts with adenylate cyclase, activating PKA/CREB, and inhibiting G

133 ption through a calcium-dependent isoform of adenylate cyclase, ADCY8, and the transcription factor,

134 ivation of A1 receptors causes inhibition of adenylate cyclase, decreases in intracellular cyclic AMP

135 Furthermore, we find that adenylate cyclase, PKA, CaMKII, and release of Ca(2+) fr

136 f AMP and related nucleotides, which inhibit adenylate cyclase, reduce levels of cyclic AMP and prote

137 ogous G-protein alpha subunits that activate adenylate cyclase, thereby serving as crucial mediators

138 ssociation studies have implicated pituitary adenylate cyclase-activating peptide (PACAP) systems in

139 The activation of pituitary adenylate cyclase-activating peptide (PACAP) systems in

140 strong homology with the mammalian pituitary adenylate cyclase-activating peptide (PACAP).

141 structures of peptide and Gs-bound pituitary adenylate cyclase-activating peptide, PAC1 receptor, and

142 Pituitary adenylate cyclase-activating polypeptide (PACAP) and glu

143 found higher circulating levels of pituitary adenylate cyclase-activating polypeptide (PACAP) associa

144 There is a deficit of pituitary adenylate cyclase-activating polypeptide (PACAP) in pati

145 Pituitary adenylate cyclase-activating polypeptide (PACAP) is a ne

146 Recent work indicates that pituitary adenylate cyclase-activating polypeptide (PACAP) plays a

147 such brain stress response system, pituitary adenylate cyclase-activating polypeptide (PACAP), and it

148 olypeptide type I receptor (PAC1), pituitary adenylate cyclase-activating polypeptide (PACAP)-38, or

149 n, a receptor for the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP).

150 nt melanopsin and the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP).

151 Growing evidence suggests that the pituitary adenylate cyclase-activating polypeptide (PACAP)/PAC1 re

152 tropin-releasing hormone (TRH) and pituitary adenylate cyclase-activating polypeptide (PACAP, also kn

153 Pituitary adenylate cyclase-activating polypeptide (PACAP; Adcyap1

154 The G protein-coupled pituitary adenylate cyclase-activating polypeptide receptor (PAC1R

155 with the endogenous agonist of the pituitary adenylate cyclase-activating polypeptide type I receptor

156 stromal-derived factor-1alpha, and pituitary adenylate cyclase-activating polypeptide, which may impr

157 , we developed a highly efficient detoxified adenylate cyclase-based vector (CyaA) capable of deliver

158 pends on the G(alpha) subunit via a G(alpha)-adenylate cyclase-cAMP cascade and requires participatio

159 We overcame this toxicity by developing an adenylate cyclase-knockout E. coli cell line.

160 se through the LANCL2-mediated activation of adenylate cyclase.

161 omyocyte proliferation through inhibition of adenylate cyclase.

162 TX effector domain is a catalytically active adenylate cyclase.

163 pression of genes such as cAMP receptors and adenylate cyclase.

164 kinase A by a bicarbonate-dependent soluble adenylate cyclase.

165 perform uncoupled respiration downstream of adenylate cyclase.

166 ansduction from beta-adrenergic receptors to adenylate cyclase.

167 d was rescued by pharmacological blockade of adenylate cyclase.

168 he specific inhibitory action of GnIH on the adenylate cyclase/cAMP/protein kinase A pathway, suggest

169 with epithelial tropism and the role of the adenylate cyclase/PKA/AKT-mediated signaling pathway in

170 tion of synaptic transmission induced by the adenylate-cyclase activator forskolin in cultured cortic

171 uction within the inner ear, is catalyzed by adenylate cyclases (AC).

172 which still occurred in mutants lacking the adenylate cyclases ACG or ACR, or the cAMP phosphodieste

173 We deleted PKA and the adenylate cyclases AcrA and AcgA, which synthesize cAMP

174 ve evolution to accommodate the emergence of adenylate cyclases and thus the signaling molecule 3',5'

175 Adenylate cyclases convert intra- and extracellular stim

176 satility, naturally occurring photoactivated adenylate cyclases promote the synthesis of the second m

177 re, we tested this hypothesis by engineering adenylate cyclases regulated by light in the near-infrar

178 reported structures of mRNA capping enzymes, adenylate cyclases, and polyphosphate polymerases sugges

179 f a GAF (cGMP-stimulated phosphodiesterases, adenylate cyclases, FhlA) domain that binds BCAAs and a

180 blocked repair intermediates containing a 5'-adenylated-deoxyribose phosphate (5'-AMP-dRP) group.

181 R) intermediates containing the 5'-AMP or 5'-adenylated-deoxyribose phosphate (5'-AMP-dRP) lesions ma

182 e 3'UTR, suggesting that RdRp binding to the adenylates disrupts H4a/Psi3, leading to loss of H5/H4b

183 Moreover, we find that ligation by de-adenylated DNA ligase IV is dependent upon ATP not NAD+

184 e that NAD+ does not enhance ligation by pre-adenylated DNA ligase IV, indicating that this co-factor

185 nate with each other in processing of the 5'-adenylated dRP-containing BER intermediate.

186 theta and Ku70) were found to remove the 5'-adenylated-dRP group from the BER intermediate.

187 ments showed that this activating enzyme can adenylate each of these sulphur-carrier proteins and pro

188 zed adherently yielded higher values for the adenylate energy charge (0.90 +/- 0.09 for adherent cell

189 llular response to metabolic modulators, the adenylate energy charge (AEC) levels for control and rot

190 roducts, which were accompanied by decreased adenylate energy states and starch levels, and impaired

191 ion resulted in imbalances in both redox and adenylate energy.

192 The adenylating enzyme MbtA catalyzes the first step of myco

193 rough an ester generated by an ATP-dependent adenylating enzyme.

194 uc1-3, all members of the ANL superfamily of adenylating enzymes.

195 ) consists of a DMAP1-binding domain and two adenylate-forming domains (AFDs).

196 Here we used machine learning to predict adenylate-forming enzyme function and substrate specific

197 rehensively map the biochemical diversity of adenylate-forming enzymes across >50,000 candidate biosy

198 trates and functions of the vast majority of adenylate-forming enzymes are unknown without tools avai

199 Given the crucial roles of adenylate-forming enzymes in biosynthesis, this also sev

200 Class I adenylate-forming enzymes share a conserved structural f

201 ave arisen from simple modifications to acyl-adenylate-forming enzymes.

202 f proteins in Arabidopsis and belongs to the adenylate-forming family of enzymes.

203 lusters suggested divergent evolution of the adenylate-forming superfamily from a core enzyme scaffol

204 sser extent ADP-ribose, as the source of the adenylate group and that NAD+, unlike ATP, enhances liga

205 eening using HIV-reverse transcriptase (RT), adenylate/guanylate kinase, and human DNA polymerase gam

206 an McC maturation intermediate consisting of adenylated heptapeptide.

207 also found that SIRT1 can regulate levels of adenylated hTR through PARN.

208 in vivo, by quantifying endogenous levels of adenylated hTR.

209 While mapping total and poly-adenylated human transcriptomes has now become routine,

210 f the structures of two complexes with alkyl adenylate inhibitors has provided direct information, wi

211 nylate to the 5'-PO(4) DNA end to form a DNA-adenylate intermediate (AppDNA).

212 itin or ubiquitin-like proteins (Ubl) via an adenylate intermediate and initiate the enzymatic cascad

213 transferases, formation of a covalent enzyme-adenylate intermediate is a common first step of all DNA

214 tor to form a covalent enzyme-(lysine-Nzeta)-adenylate intermediate.

215 on requiring neither a phosphorylated nor an adenylated intermediate.

216 to either RNA 3'p or DNA 3'p to generate the adenylated intermediate.

217 s activate fatty acids with ATP to form acyl-adenylate intermediates, but only luciferases can activa

218 These 3'-terminal phosphate-adenylated intermediates are substrates for deadenylatio

219 lective rejection of a non-protein aminoacyl-adenylate is in addition to known kinetic discrimination

220 The enzyme adenylate kinase (ADK) features two substrate binding do

221 the closed-to-open transitions of the enzyme adenylate kinase (AdK) in its substrate-free form, we co

222 tability, and function of a selected enzyme, adenylate kinase (Adk), by monitoring changes in its enz

223 lucosamine-6-phosphate deaminase (NagB), and adenylate kinase (Adk).

224 ional fluctuations in the phosphotransferase adenylate kinase (AK) throughout its active reaction cyc

225 utral cholesterol ester hydrolase 1 (Nceh1), adenylate kinase 1 (Ak1), inositol polyphosphate 5-phosp

226 ucleoside triphosphate diphosphohydrolase 5/ adenylate kinase 1/cytidine monophosphate kinase 1 axis

227 itochondrial energy metabolism and caused by adenylate kinase 2 (AK2) deficiency.

228 Adenylate kinase 2 (AK2), which balances adenine nucleot

229 The gene AK2 encodes the phosphotransferase adenylate kinase 2 (AK2).

230 ing two of high confidence, calreticulin and adenylate kinase 2.

231 ributing to root growth control: Arabidopsis Adenylate Kinase 6 (AAK6).

232 tenance of chromosome (SMC) protein, exhibit adenylate kinase activity in the presence of physiologic

233 Furthermore, the results suggest that adenylate kinase activity is important for normal CFTR c

234 ly activates the ATPase activity but not the adenylate kinase activity of Fap7, identifying Rps14 as

235 te photolabeling of the AMP-binding site and adenylate kinase activity were disrupted in Q1291F CFTR.

236 axonemal module including dynein ATPases and adenylate kinase as well as CFAP52, whose mutations caus

237 domain of an SMC protein in complex with the adenylate kinase bisubstrate inhibitor P(1),P(5)-di(aden

238 rther indicate that the active center of the adenylate kinase comprises ATP-binding site 2.

239 tive tissues, in which AMP is generated from adenylate kinase during states of high energy demand, th

240 e bond, we succeeded in arresting the enzyme adenylate kinase in a closed high-energy conformation th

241 ff, and suggests that the catalytic speed of adenylate kinase is an evolutionary driver for organisma

242 cale motions observed upon ligand binding to adenylate kinase is dominated by enzyme-substrate intera

243 We also demonstrate that Adenylate kinase isoenzyme 1 (AK1) inactivates antimetab

244 concerted action of alkaline phosphatase and adenylate kinase proved crucial for ADP/ATP generation f

245 to the conserved Q-loop glutamine during the adenylate kinase reaction.

246 ying thermoadaptation of enzyme catalysis in adenylate kinase using ancestral sequence reconstruction

247 rements of the refolding of Escherichia coli adenylate kinase were analyzed.

248 systems of broad biological interest such as adenylate kinase, ATP-driven calcium pump SERCA, leucine

249 ting conformational transition in the enzyme adenylate kinase, by a synergistic approach between expe

250 e previously reported free energy surface of adenylate kinase, deformations along the first mode prod

251 AEW, and NaOCl treatments were identified as adenylate kinase, phosphoglycerate kinase, glyceraldehyd

252 ic concentrations of ADP and AMP were added, adenylate kinase-deficient Q1291F channels opened signif

253 n ABC transporter plays an important role in adenylate kinase-dependent CFTR gating.

254 idue in CFTR, Gln-1291, selectively disrupts adenylate kinase-dependent channel gating at physiologic

255 Adenylate kinases (AKs) are phosphotransferases that reg

256 This method is capable of adenylating large amounts of adapter at ~100% efficiency

257 ecent studies have suggested that low energy adenylate ligands bound to one or more sites in the gamm

258 formation of a DNA-bridging intermediate by adenylated LigIII that positions a pair of blunt-ended d

259 e enzymes use ATP to activate lipoate to its adenylate, lipoyl-AMP, which remains tightly bound in th

260 In the first, with a Ub-adenylate mimetic (Ub-AMSN) bound, the E1 is in an open

261 Adenylate mutations eliminated one-site RdRp binding to

262 demonstrate a role for APTX in resolving 5'-adenylated nucleic acid breaks, however, APTX function i

263 The pool sizes of both pyridine and adenylate nucleotides in sta6 increased substantially to

264 cal salt-bridge contact with the 3'-terminal adenylate of aa-tRNA.

265 Adenylate phosphorylation state assays and mitochondrial

266 rget only the N7-methylated cap structure of adenylate-primed RNA substrates.

267 nicks in double-stranded DNA to produce a 3'-adenylated product.

268 ylated RNAs which neglects RBPs bound to non-adenylate RNA classes (tRNA, rRNA, pre-mRNA) as well as

269 e entire genome can be transcribed into poly-adenylated RNA when viewed at an evolutionary time scale

270 these results indicate that accumulation of adenylated RNA-DNA may contribute to neurological diseas

271 APTX efficiently repairs adenylated RNA-DNA, and acting in an RNA-DNA damage resp

272 t RNA ligase may act on a specific set of 3'-adenylated RNAs to regulate their processing and downstr

273 less is known about the distribution of non-adenylated RNAs.

274 PR (Acr) that degrades cA(4), a cyclic oligo-adenylate second messenger produced during the type III

275 Binding of NucC trimers to a cyclic tri-adenylate second messenger promotes assembly of a NucC h

276 ovibrio ammonificans, TVa, were also able to adenylate ssDNA 3'p.

277 side with the d-ribo configuration and seryl-adenylate supplied by the serine adenylation activity of

278 ria, YrdC synthesises an l-threonylcarbamoyl adenylate (TC-AMP) intermediate, and OSGEPL1 transfers t

279 thesis of the intermediate threonylcarbamoyl adenylate (TC-AMP), followed by transfer of the threonyl

280 rate beetle luciferin into the corresponding adenylate that it subsequently oxidizes to oxyluciferin,

281 g a soluble enzyme FadD10 to form fatty acyl adenylates that react with amine-functionalized lysolipi

282 red by synthesis of biotinoyl-AMP (biotinoyl-adenylate), the intermediate in the ligation of biotin t

283 ction to deadenylate the 5'-AMP from the RNA-adenylate, thereby inhibiting step 3 reaction.

284 e catalyzes attack by a DNA 3'-OH on the DNA-adenylate to seal the two ends via a phosphodiester bond

285 In step 2, AMP is transferred from ligase-adenylate to the 5'-PO(4) DNA end to form a DNA-adenylat

286 aracterize the phylogenetic turnover of poly-adenylated transcripts in a comprehensive sampling of ta

287 evels of substrates, demonstrating that both adenylate turnover and substrate supply can limit leaf R

288 75% could be explained by a deactivation of adenylate-uridylate-rich element (ARE)-binding protein B

289 e observed AA-like symptoms in our IFN-gamma adenylate-uridylate-rich element (ARE)-deleted (del) mic

290 rotein tristetraprolin (TTP) and a conserved adenylate-uridylate-rich element in the TF mRNA 3' untra

291 NA-binding protein that recognizes conserved adenylate-uridylate-rich elements (ARE) located in 3'unt

292 nc-finger mRNA binding protein that binds to adenylate-uridylate-rich elements (AREs) in the 3'-untra

293 ely regulates HIF1A expression by binding to adenylate-uridylate-rich elements in the 3'-UTR region o

294 MR mRNA, containing several highly conserved adenylate/uridylate-rich elements (AREs), were cloned do

295 a key regulator of cellular mRNAs containing adenylate/uridylate-rich elements (AU-rich elements; ARE

296 e a toxic warhead-a nonhydrolyzable aspartyl-adenylate, which inhibits aspartyl-tRNA synthetase.

297 leasing a nonhydrolyzable analog of aspartyl-adenylate, which inhibits aspartyl-tRNA synthetase.

298 toxic warhead-a nonhydrolyzable aspartamidyl-adenylate, which inhibits aspartyl-tRNA synthetase.

299 ese cells resulted in immediate depletion of adenylates, which plays a central role in mediating mTOR

300 acid proceeds by direct reaction of the acyl adenylate with amine nucleophiles.