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1 of AMP, coupling L-aspartate and IMP to form adenylosuccinate.
2 cated close to the succinyl moiety of docked adenylosuccinate.
3 ndence of V(max) but no loss in affinity for adenylosuccinate.
4 hate, and Mg(2+), adopts the binding mode of adenylosuccinate.
5 s as an analogue of IMP or as an analogue of adenylosuccinate.
6 d an apparent Km of approximately 24 mum for adenylosuccinate.
7 talytic acids in the subsequent formation of adenylosuccinate.
8 Within this pathway, the bifunctional enzyme adenylosuccinate (ADS) lyase plays a role in the formati
9 lude that 6-BDB-TAMP functions as a reactive adenylosuccinate analog in modifying His141 in the subst
10 lude that 6-BDB-TAMP functions as a reactive adenylosuccinate analogue in modifying both Arg131 and A
11 s of the purine nucleotide cycle (PNC): IMP, adenylosuccinate, and AMP.
12 rvations suggest that 2-BDB-TAMP attacks the adenylosuccinate binding site.
13                                              Adenylosuccinate binding studies of the other mutants re
14 rvations suggest that 6-BDB-TAMP targets the adenylosuccinate-binding site.
15 DP.Mg(2+).sulfate, the first structure of an adenylosuccinate-bound synthetase, reveals significant g
16 is subject to feedback inhibition by AMP and adenylosuccinate, but crystallographic complexes of the
17 ent of the reversible binding of radioactive adenylosuccinate by inactive mutant enzymes with substit
18  showed lower nucleotide synthesis on day 1: adenylosuccinate concentrations were 0.08 (0.04-0.12) re
19 d to a specific activity of 1.56 micromol of adenylosuccinate converted/min/mg protein for wild-type
20                                              Adenylosuccinate forms from 6-phosphoryl-IMP and l-aspar
21 rom GTP and IMP followed by the formation of adenylosuccinate from 6-phosphoryl-IMP and l-aspartate.
22 tase, putatively catalyzing the formation of adenylosuccinate from an intermediate of 6-phosphoryl-IM
23                               The complex of adenylosuccinate.GDP.Mg(2+).sulfate, the first structure
24 AMP + 5 mM fumarate (the natural products of adenylosuccinate hydrolysis) but not by 0.1 mM 5'-AMP al
25 P is a competitive inhibitor with respect to adenylosuccinate in the catalytic reaction and also decr
26 an be explained by selective accumulation of adenylosuccinate in the Deltaasl knock-out and consequen
27                        In H89Q, the K(M) for adenylosuccinate increases slightly to 2.5-fold that of
28                                 The K(m) for adenylosuccinate is elevated in the X62D mutants, and I6
29 6E are considerably reduced and affinity for adenylosuccinate is retained.
30 n followed by mass spectrometry, we identify adenylosuccinate lyase (ADSL) as an EglN2 hydroxylase su
31                                              Adenylosuccinate lyase (ADSL) deficiency is a rare autos
32 a critical role in de novo purine synthesis, adenylosuccinate lyase (ADSL) expression is upregulated
33                                              Adenylosuccinate lyase (ADSL) functions in de novo purin
34 alysis confirmed that fumarate, generated by adenylosuccinate lyase (ADSL) in the de novo purine synt
35                                        Human adenylosuccinate lyase (ASL) deficiency is an inherited
36  Both adenylosuccinate synthetase (ADSS) and adenylosuccinate lyase (ASL) have been identified as vit
37                                   Tetrameric adenylosuccinate lyase (ASL) of Bacillus subtilis cataly
38                                              Adenylosuccinate lyase (ASL) of Bacillus subtilis is a h
39                                              Adenylosuccinate lyase (ASL), a catalyst of key reaction
40 ygous for two mutations in the gene encoding adenylosuccinate lyase (ASL), resulting in the protein m
41 ase (hpt), adenylosuccinate synthase (purA), adenylosuccinate lyase (purB), auxiliary protein (nrdI),
42 tetramer and this structure is essential for adenylosuccinate lyase activity.
43 d Arg(301) are indispensable to catalysis by adenylosuccinate lyase and probably interact noncovalent
44 ate sites in adenylosuccinate synthetase and adenylosuccinate lyase and to regulatory sites of glutam
45                  Thus 2-BDB-TAMP reacts with adenylosuccinate lyase at a site distinct from the His14
46  studies suggest that 2-BDB-TAMP inactivates adenylosuccinate lyase by specific reaction at the subst
47                                              Adenylosuccinate lyase catalyzes two separate reactions
48      Similar to other two known DNPS defects-adenylosuccinate lyase deficiency and AICA-ribosiduria-t
49  show here for the first time that wild-type adenylosuccinate lyase exhibits a protein concentration
50                                           In adenylosuccinate lyase from Bacillus subtilis, Gln(212),
51               Surprisingly, the structure of adenylosuccinate lyase from P. aerophilum reveals that t
52                     The crystal structure of adenylosuccinate lyase from the hyperthermophilic archae
53 re of the tetrameric assembly are similar to adenylosuccinate lyase from the thermophilic eubacterium
54                                        Thus, adenylosuccinate lyase has four active sites per enzyme
55 d not inhibit adenylosuccinate synthetase or adenylosuccinate lyase isolated from Zea mays.
56 esidue Glu275 (both His141 and Glu275 are in adenylosuccinate lyase numbering), acts as the general b
57                                              Adenylosuccinate lyase of Bacillus subtilis is a tetrame
58                                              Adenylosuccinate lyase of Bacillus subtilis is inactivat
59                                              Adenylosuccinate lyase of Bacillus subtilis is inactivat
60     Through its dual action in this pathway, adenylosuccinate lyase plays an integral part in cellula
61                                Rabbit muscle adenylosuccinate lyase upon incubation with 7.5-50 muM 2
62                    A tetrameric structure of adenylosuccinate lyase was constructed by homology model
63                Asn(276) of Bacillus subtilis adenylosuccinate lyase, a residue corresponding to the l
64                                              Adenylosuccinate lyase, an enzyme catalyzing two reactio
65  kinase, anaerobic ribonucleotide reductase, adenylosuccinate lyase, and a hypothetical protein.
66 he de novo purine biosynthesis pathway, ASL (adenylosuccinate lyase, Step 8) and ATIC (5-aminoimidazo
67 ying His141 in the substrate-binding site of adenylosuccinate lyase, where it may serve as a general
68  the substrate binding site of rabbit muscle adenylosuccinate lyase.
69 nt for the catalytic activity of B. subtilis adenylosuccinate lyase.
70 41 is the reaction product of 6-BDB-TAMP and adenylosuccinate lyase.
71                                       Mutant adenylosuccinate lyases of Bacillus subtilis were prepar
72 position 276 result in structurally impaired adenylosuccinate lyases which are assembled into defecti
73 -4(N-succinylocarboxamide)ribonucleotide and adenylosuccinate, optimizing their bound orientations.
74 incorporation of [32P]reagent is provided by adenylosuccinate or a combination of AMP and fumarate, w
75              Active site nucleotides, either adenylosuccinate or IMP + GTP, prevent both slower phase
76                  Active-site ligands, either adenylosuccinate or IMP and GTP, completely prevent inac
77  purine biosynthesis (the cleavage of either adenylosuccinate or succinylaminoimidazole carboxamide r
78                                              Adenylosuccinate, or a combination of AMP and fumarate,
79                 Binding studies using [2-3H]-adenylosuccinate reveal that none of the Glu275 mutant e
80 ) in human erythrocytes or recombinant human adenylosuccinate synthase (ADSS).
81 ine-guanine phosphoribosyltransferase (hpt), adenylosuccinate synthase (purA), adenylosuccinate lyase
82                                         Both adenylosuccinate synthetase (ADSS) and adenylosuccinate
83                                              Adenylosuccinate synthetase (AdSS) is the site of action
84 tions in the ADSS1 gene, encoding the enzyme adenylosuccinate synthetase (AdSS1).
85 carnitine palmitoyl transferase I and muscle adenylosuccinate synthetase (ADSS1).
86                 A muscle-specific isoform of adenylosuccinate synthetase (AdSS1, EC) is one of three
87 tered activity of the IMP utilizing enzymes, adenylosuccinate synthetase (PurA) and IMP dehydrogenase
88 e reported that 1.9 kilobase pairs of murine adenylosuccinate synthetase 1 gene (Adss1) 5'-flanking D
89 otide analogs directed to substrate sites in adenylosuccinate synthetase and adenylosuccinate lyase a
90                     The activities of IMPDH, adenylosuccinate synthetase and GMP reductase were two t
91                                    Wild-type adenylosuccinate synthetase and three mutant synthetases
92 site of action of hydantocidin and establish adenylosuccinate synthetase as an herbicide target of co
93 nalysis of the mode of inhibition of a plant adenylosuccinate synthetase by the active metabolite 5'-
94                                              Adenylosuccinate synthetase catalyzes the first committe
95 eriments, that suggest that Escherichia coli adenylosuccinate synthetase contains two shared active s
96 sults indicate that both subunits of dimeric adenylosuccinate synthetase contribute to each active si
97 of the stringent response, potently inhibits adenylosuccinate synthetase from Escherichia coli as an
98                        Crystal structures of adenylosuccinate synthetase from Escherichia coli comple
99                                Structures of adenylosuccinate synthetase from Escherichia coli comple
100 mplete set of substrate/substrate analogs of adenylosuccinate synthetase from Escherichia coli induce
101                  The state of aggregation of adenylosuccinate synthetase from Escherichia coli is a p
102                                              Adenylosuccinate synthetase from Escherichia coli is ina
103                                              Adenylosuccinate synthetase from Escherichia coli is ina
104                       A crystal structure of adenylosuccinate synthetase from Escherichia coli, compl
105 re not involved in the chemical mechanism of adenylosuccinate synthetase from Escherichia coli, yet t
106 ytic function and structural organization of adenylosuccinate synthetase from Escherichia coli.
107                        Crystal structures of adenylosuccinate synthetase from Esherichia coli complex
108 es containing a synthetic promoter/antisense adenylosuccinate synthetase gene.
109                                              Adenylosuccinate synthetase governs the committed step o
110                                              Adenylosuccinate synthetase governs the first committed
111  including EF-Tu, Ypt1, rab-5, and FtsY, and adenylosuccinate synthetase have been reported to bind x
112          Hydantocidin itself did not inhibit adenylosuccinate synthetase or adenylosuccinate lyase is
113 ion was alluded to by use of mutant forms of adenylosuccinate synthetase previously prepared by site-
114 ure and site-directed mutagenesis of E. coli adenylosuccinate synthetase show that Arg303 interacts w
115            Prokaryotes have a single form of adenylosuccinate synthetase that controls the committed
116  IMP to XMP or AMP (IMP dehydrogenase, guaB; adenylosuccinate synthetase, purA, and ADE12), and unabl
117    Asp13 and His41 are essential residues of adenylosuccinate synthetase, putatively catalyzing the f
118 ertebrates have acidic and basic isozymes of adenylosuccinate synthetase, which participate in the fi
119 sponding positions in all known sequences of adenylosuccinate synthetase.
120 for SAICAR synthetase that parallels that of adenylosuccinate synthetase.
121  from IMP because of a developmental loss of adenylosuccinate synthetase.
122 tructure determination of a basic isozyme of adenylosuccinate synthetase.
123          Vertebrates possess two isozymes of adenylosuccinate synthetase.
124 both Arg131 and Arg303 in the active site of adenylosuccinate synthetase.
125 in the crystal structure of Escherichia coli adenylosuccinate synthetase.
126 rved differences in ligand recognition among adenylosuccinate synthetases may be due in part to confo
127                     V(max) for conversion of adenylosuccinate to AMP and fumarate is 0.57 micromol/mi
128 meric enzyme which catalyzes the cleavage of adenylosuccinate to AMP and fumarate.
129 novo synthesis of IMP, and the conversion of adenylosuccinate to AMP, which occurs in the de novo syn
130  Bacillus subtilis catalyzes the cleavage of adenylosuccinate to form AMP and fumarate.
131 ween adenosine and inosine monophosphate and adenylosuccinate, which consumes aspartate and releases

 
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