ライフサイエンスコーパス: adhesion site

1 e surrounding the MIDAS (metal ion-dependent adhesion site).

2 e and close to the beta3 metal ion-dependent adhesion site.

3 erface that includes the metal ion-dependent adhesion site.

4 nge protein diffusion in the membrane to the adhesion site.

5 cture at the apex that likely represents the adhesion site.

6 omes are preferentially deposited at the new adhesion site.

7 ction of area, shape, and orientation of the adhesion sites.

8 tegrin in podosome and focal adhesion matrix adhesion sites.

9 ding, edge retraction, and initiation of new adhesion sites.

10 a protein that enhances Src effectiveness at adhesion sites.

11 of paxillin, vinculin and actin at cell-ECM adhesion sites.

12 ed to describe force regulation by dynamical adhesion sites.

13 pendent pathway that is activated locally at adhesion sites.

14 sitive regulator of Src activity at integrin adhesion sites.

15 found to be an important component of focal adhesion sites.

16 cruitment of KLEIP as well as F-actin to the adhesion sites.

17 onto plastic substrates containing selective adhesion sites.

18 osphotyrosine signaling at integrin-mediated adhesion sites.

19 ytoskeletal organization and increased focal adhesion sites.

20 by VEGF and found to be important for focal adhesion sites.

21 eads to actin filament assembly near nascent adhesion sites.

22 nor tensin localize to fibrillar cell-matrix adhesion sites.

23 age of polysaccharides and putative RGD cell adhesion sites.

24 rtments, including the nucleus and cell-cell adhesion sites.

25 ant roles at cell-extracellular matrix (ECM) adhesion sites.

26 y, 12(S)-HETE causes the loss of growth cone adhesion sites.

27 ity to shuttle between the nucleus and focal adhesion sites.

28 was restricted to GSK3beta present at focal adhesion sites.

29 skeletal organization and phosphorylation at adhesion sites.

30 results in morphologically defective nascent adhesion sites.

31 a random, non-oriented distribution of focal adhesion sites.

32 lined by actin bundles form between adjacent adhesion sites.

33 cone, the actin cytoskeleton and substratum adhesion sites.

34 pends on the appropriate spacing of integrin adhesion sites.

35 ssembly of the vimentin cytoskeleton at cell adhesion sites.

36 ained a reduced amount of phosphotyrosine at adhesion sites.

37 tion of both vinculin and phosphotyrosine at adhesion sites.

38 rophil rolling by competing for the selectin-adhesion sites.

39 relate with an altered organization of focal adhesion sites.

40 timately exhibit differential trafficking to adhesion sites.

41 tractile myosin structures at the epithelial adhesion sites.

42 integrin-p-FAK complexes to newly assembling adhesion sites.

43 nt of spreading is limited by the density of adhesion sites.

44 omyosin-dependent tension across VE-cadherin adhesion sites.

45 reover, they have abnormally arranged matrix adhesion sites.

46 ultiple cellular forces may be integrated at adhesion sites.

47 cytosol as multi-protein building blocks for adhesion sites.

48 f these two closely related kinases in focal adhesion sites.

49 nocytes via profound effects on their matrix adhesion sites.

50 g neurites by maintaining their structure at adhesion sites.

51 n between the cell and the substrate through adhesion sites.

52 ubule (MT)-based cytoskeletons at these cell adhesion sites.

53 a high turnover of actin polymerization and adhesion sites.

54 t with ICAM-1 and are recruited to leukocyte adhesion sites.

55 ion, maturation, and turnover of matrix-cell adhesion sites.

56 oss-linker and may act as a mechanosensor in adhesion sites.

57 integrin-linked kinase were not recruited to adhesion sites.

58 re concave cell edges were anchored to FN by adhesion sites.

59 ng clathrin adaptors and dynamin 2, to focal adhesion sites.

60 apidly, and correctly as diverse cell-matrix adhesion sites?

61 th fixed area is not possible for stationary adhesion sites, according to elasticity theory.

62 tance of the adjacent to metal ion-dependent adhesion site (ADMIDAS) in integrin activation by Mn(2+)

63 S), site adjacent to the metal ion-dependent adhesion site (ADMIDAS), and ligand-induced metal-bindin

64 bound to the adjacent to metal ion-dependent adhesion site (ADMIDAS), at the locus of shape shifting,

65 ain known as adjacent to metal ion-dependent adhesion site (ADMIDAS).

66 LMO7 was assembled at the cell-cell adhesion sites after both the nectin-afadin and E-cadher

67 ated morphology with stress fibers and focal adhesion sites aligned parallel to the lines.

68 reatest staining intensity being observed at adhesion sites along the cell periphery.

69 domain and activates its metal ion-dependent adhesion site, analogously to activation of the integrin

70 occur that activate the metal ion-dependent adhesion site and partially stabilize the complex.

71 the conformation of the metal ion-dependent adhesion site and the position of the alpha7 helix of th

72 tracellular matrix regulate local tension at adhesion sites and activate local tyrosine phosphorylati

73 trix, FAK is being translocated toward focal adhesion sites and activated.

74 acellular environment through integrin-based adhesion sites and adapt to the extracellular milieu in

75 ected to impact on the accessibility of cell adhesion sites and altered fibril surface charge on the

76 omponents and their dynamic exchange between adhesion sites and cytosol.

77 dulates microfilament attachment at muscular adhesion sites and furthers our understanding of MV-medi

78 d their substrate relies on the formation of adhesion sites and on the stabilization of contractile a

79 ment of endogenous ILK and PINCH to integrin adhesion sites and prevented their association of ILK wi

80 has been associated to the shielding of its adhesion sites and proteolytic cleavage.

81 with FAK may signal the destruction of focal adhesion sites and regulate the onset of apoptosis.

82 stemming from their reduced diffusion within adhesion sites and slow turnover of FA.

83 ymerization at upstream alpha4beta1 integrin adhesion sites and the adjacent cortical cytoskeleton.

84 yr(747) and Tyr(759) of beta(3) in the focal adhesion sites and the leading edge of spreading platele

85 s between their extracellular ligand binding adhesion sites and their cytoplasmic domains, which link

86 ith loss of pp125FAK and paxillin from focal adhesion sites and their redistribution into the charact

87 "sticky fingers" mechanism to probe for new adhesion sites and to direct migration.

88 prevented the translocation of FAK to focal adhesion sites and tyrosine phosphorylation of FAK and p

89 ch other with plenty of water present at the adhesion sites) and k = 7 (one peptide chain pulled out

90 that the RGD at alpha572-574 is the primary adhesion site, and that the gamma chain site plays no si

91 ce chemistry to provide spatial control over adhesion sites, and elastic deformations of a supporting

92 process are membrane blebbing, loss of focal adhesion sites, and retraction from the matrix followed

93 localizes to cell-extracellular matrix (ECM) adhesion sites, and this process requires binding to vin

94 grins upregulates traction forces at cell-FN adhesion sites, and thus provide additional insight into

95 serves as a FAK repressor to stabilize focal adhesion sites, and when LKB1 function is compromised, a

96 Microtubules regulate the turnover of adhesion sites, and, in turn, focal adhesions promote th

97 y proportional to the ratio of corresponding adhesion site areas.

98 ng partners and the localization of SAP97 at adhesion sites, as well as the clustering of ion channel

99 -related anonymous protein (TRAP)-containing adhesion sites assemble, our data suggest that the dense

100 amily kinases have distinct functions during adhesion site assembly, and that RPTPalpha is an early c

101 connections and no role in stretch-dependent adhesion site assembly.

102 The waves originate from one major adhesion site at leading end of the cell body, which is

103 e face known to bear the metal ion-dependent adhesion site, at the opposite end of the alphaI domain

104 in concert to shift the metal-ion-dependent adhesion site between the resting and active states.

105 Synapses are specialized adhesion sites between neurons that are connected by pro

106 ia may involve the formation of the membrane adhesion sites between the inner and the outer membranes

107 membrane tension serving as a measure of the adhesion sites between the plasma membrane and the F-act

108 ordination of a receptor metal ion-dependent adhesion site-bound metal ion is governed by the seconda

109 M domain abolished targeting of p62 to focal-adhesion sites but did not interfere with binding of p62

110 orrelate with growth cone advance toward the adhesion site, but the amount of microneedle deflection

111 followed by adjacent to metal ion-dependent adhesion site Ca(2+), alpha1 helix, alpha1' helix, beta6

112 and a(2)d-3 with mutated metal ion-dependent adhesion sites can fully rescue presynaptic synapsin exp

113 cell with the extracellular matrix relies on adhesion sites, clusters of membrane-associated proteins

114 t this requires integrin-associated cell-ECM adhesion sites (CMAs) and actomyosin-mediated forces, th

115 ytoskeletal organization and increased focal adhesion sites compared with control cells or cells trea

116 tures that consist of two fibronectin-coated adhesion sites connected by a thin guidance cue.

117 elated time lapse-electron microscopy, these adhesion sites contained a focal ring (an oblate, donut-

118 with extracellular matrix proteins at focal adhesions sites contributes to the integrity of vascular

119 etween VLA-4 on the T lymphocytes and the FN adhesion site CS-1.

120 ention through decreasing attachment rate or adhesion site density in the lung by 50% could increase

121 ractions are Mg(2+)- and metal ion-dependent adhesion site-dependent.

122 e stiffness, and that the stress measured at adhesion sites depends on substrate rigidity.

123 pt it lacks a functional metal ion-dependent adhesion site domain and is expressed without an alpha-c

124 targeting mechanism for properly localizing adhesion sites during cell motility.

125 nd alpha-parvin may be recruited to membrane adhesion sites during contractile stimulation of trachea

126 ty, yet the effects of axon guidance cues on adhesion site dynamics are poorly understood.

127 This shows for the first time that adhesion site dynamics are regulated during adhesion for

128 In correlation, adhesion site dynamics, measured by fluorescence recover

129 ed with alpha-actinin assembly and decreased adhesion site dynamics.

130 aterial and impacting actin organization and adhesion site dynamics.

131 The adhesion site effect seems partially independent of the

132 both Calpain 2 and p42ERK/MAPK to peripheral adhesion sites facilitating maximal Calpain activity.

133 vinculin-containing, actin-terminating focal adhesion sites (FAS) per cell.

134 gl-Glt complex) localizes to so-called focal adhesion sites (FASs) that form stationary contact point

135 ins regulate hard tissue growth by acting as adhesion sites for cells, by triggering cell signaling p

136 In this report, the adhesion sites for human dermal fibroblasts on fibrinoge

137 for the normal development of cells, and are adhesion sites for various infectious agents.

138 We show that as adhesion sites form between fusion cells, myosin and mic

139 ats exhibit impaired motility due to altered adhesion site formation and dynamics. Since CSP forms th

140 tegrin-cytoskeleton connections and initiate adhesion site formation.

141 is altered in the repeat mutants, affecting adhesion site formation.

142 rotein were acutely directed to F-actin-rich adhesion sites from the adipocyte cytoplasm in response

143 ytoskeletal rearrangements and detachment of adhesion sites from the extracellular matrix, via mostly

144 h local actin assembly forces buffer nascent adhesion sites from the mechanical effects of retrograde

145 Nascent adhesion sites have been shown to regulate these forces

146 d bind a Mg(2+) ion at a metal ion-dependent adhesion site implicated in ligand binding.

147 auxiliary residue at the metal ion-dependent adhesion site in alpha(4)beta(7) is essential for bindin

148 arboxylate fixing to the metal ion-dependent adhesion site in the beta-subunit can be sufficient for

149 an essential signaling node at newly formed adhesion sites in a talin-independent manner.

150 rin and the Src family kinase p53/56(lyn) to adhesion sites in bone marrow-derived macrophages.

151 dherin and beta-catenin localization to cell adhesion sites in both cell culture and in the intact em

152 targeting of the ILK-PINCH complex to focal adhesion sites in fibroblasts during cell adhesion.

153 mechano-responsive properties of N-cadherin adhesion sites in isolated VSMCs.

154 "point contacts," which are the primary cell adhesion sites in neuronal cells.

155 ronectin-coated beads and early formation of adhesion sites in response to force, even though Src fam

156 to PAT-4 and normal localization to integrin adhesion sites in vivo.

157 sential for the formation of strong integrin adhesions sites in the developing embryo, and highlight

158 r maintaining the composition of cell-matrix adhesion sites; in the absence of fibronectin and fibron

159 lize with actin on stress fibers and at cell-adhesion sites, including neuronal synapses.

160 proximal to adjacent to metal ion-dependent adhesion site, inducing the translocation of helix a1 to

161 At these adhesion sites, integrins connect the extracellular matr

162 gen and also other tetraspanins to cell-cell adhesion sites, interferes with HIV-1 but not with influ

163 ent of the I-like domain metal ion-dependent adhesion site into a high affinity conformation.

164 , demonstrating that the metal ion-dependent adhesion site is directly coordinated by CMG2 and PA in

165 -1 ligand, ICAM-1 to the metal ion-dependent adhesion site is regulated by the I domain allosteric si

166 of VASP with activated vinculin at membrane adhesion sites is a necessary prerequisite for VASP-medi

167 We propose that molecular organization of adhesion sites is controlled by at least two mechanisms:

168 utant that is unable to localize to cell-ECM adhesion sites is incapable of exerting these effects.

169 How cells orchestrate the assembly of adhesion sites is only partially understood.

170 asymmetric distribution of these proteins at adhesion sites is reminiscent of invasive podosomes and,

171 apted to simulate cell spreading on discrete adhesion sites, it also reproduces the observed positive

172 n as focal complexes, but not in more static adhesion sites known as focal adhesions.

173 concentrate with beta 1-integrin in dynamic adhesion sites known as focal complexes, but not in more

174 otrusion, the assembly of integrin-dependent adhesion sites known as point contacts remains poorly un

175 h beta1 integrins resulting in loss of focal adhesion sites, ligand-induced focal adhesion kinase (FA

176 site within the putative metal ion-dependent adhesion site-like domain of the Pactolus gene product a

177 eed-back loop between N-cadherin and FGFR at adhesion sites limiting N-cadherin-based single-cell mig

178 Interestingly, as adhesion sites matured, contractile actin arc structures

179 t adhesion sites, thus a metal ion-dependent adhesion site-mediated adhesion mechanism may be applica

180 on of actin stress fibers, the loss of focal adhesion sites, membrane blebbing, and cell detachment.

181 -exposed residues in the metal ion-dependent adhesion site (MIDAS) (Tyr-157 and Gln-215) significantl

182 containing a functional metal ion-dependent adhesion site (MIDAS) and an associated hybrid domain.

183 between the beta I-like metal ion-dependent adhesion site (MIDAS) and an intrinsic ligand in the lin

184 The metal ion-dependent adhesion site (MIDAS) and the ligand-induced metal-bindi

185 e bivalent cation at the metal ion-dependent adhesion site (MIDAS) by a carboxylic acid function, a c

186 in contains a C-terminal metal ion-dependent adhesion site (MIDAS) domain that interacts with the N-t

187 ucture homologous to the metal ion-dependent adhesion site (MIDAS) domains of the integrin subunits a

188 Divalent cations at the metal ion-dependent adhesion site (MIDAS) face of the alpha subunit-derived

189 und that mutation of the metal ion-dependent adhesion site (MIDAS) in the alpha(E) A-domain (D190A) a

190 A metal ion-dependent adhesion site (MIDAS) in the betaA domain is positioned

191 n hexacoordinated at the metal ion-dependent adhesion site (MIDAS) in the integrin A domain.

192 ction requires an intact metal ion-dependent adhesion site (MIDAS) in the receptor as well as the pre

193 A metal ion-dependent adhesion site (MIDAS) located within this domain of the

194 tes in just one of three metal ion-dependent adhesion site (MIDAS) loops, suggesting that MIDAS loop

195 The integrin metal ion-dependent adhesion site (MIDAS) Mg(2+) ion binds the gammaC Asp si

196 borrelial adhesin with a metal ion-dependent adhesion site (MIDAS) motif that is similar to those obs

197 in contained an integrin metal ion-dependent adhesion site (MIDAS) motif, but the crystal structure s

198 nding, a function of the metal ion-dependent adhesion site (MIDAS) motif, was assessed by terbium lum

199 D sequence or the betaPS metal ion-dependent adhesion site (MIDAS) motif.

200 or A (VWA) domain with a metal ion-dependent adhesion site (MIDAS) motif.

201 ite side relative to the metal ion-dependent adhesion site (MIDAS) motif.

202 smann" fold containing a metal ion-dependent adhesion site (MIDAS) on its top face.

203 als an exposed potential metal-ion-dependent adhesion site (MIDAS) on one edge of the beta-sandwich t

204 ower" face, opposite the metal ion-dependent adhesion site (MIDAS) on the "upper face".

205 D11b revealed a putative metal ion-dependent adhesion site (MIDAS) on the top of the structure.

206 A metal ion dependent adhesion site (MIDAS) present in the integrin-like inser

207 ues localized around the metal ion-dependent adhesion site (MIDAS) was severely perturbed on ICAM-1 b

208 CMG2 metal ion-dependent adhesion site (MIDAS) was studied kinetically and thermo

209 esidues may be part of a metal ion-dependent adhesion site (MIDAS) within the beta subunit homologous

210 through an extracellular metal ion-dependent adhesion site (MIDAS), a conserved set of amino acids wi

211 e metal sites termed the metal ion-dependent adhesion site (MIDAS), site adjacent to the metal ion-de

212 ng a coordination to the metal-ion dependent adhesion site (MIDAS).

213 A-domain is known as the metal-ion dependent adhesion site (MIDAS).

214 by interacting with the metal ion dependent adhesion site (MIDAS).

215 ported to be part of the metal ion-dependent adhesion site (MIDAS).

216 nding referred to as the metal ion-dependent adhesion site (MIDAS).

217 metal ion is bound by a metal ion-dependent adhesion site (MIDAS).

218 a portion of the unique metal ion-dependent adhesion site (MIDAS).

219 due and the metal in the metal-ion-dependent adhesion site (MIDAS).

220 a divalent cation at the metal ion-dependent adhesion site (MIDAS).

221 ues within the conserved metal ion-dependent adhesion site motif impaired the ability of VWA to poten

222 a substitution near the metal ion-dependent adhesion site motif in the alpha2I domain.

223 this is mediated by the metal ion-dependent adhesion site motif within VWA.

224 he domain, including the metal ion-dependent adhesion site motif, defines the collagen recognition si

225 mediated by the I domain metal ion-dependent adhesion site motif, requires Mg(2+) or Mn(2+), is aboli

226 rin I domains containing metal ion-dependent adhesion sites motif mutations that prevent divalent cat

227 ibitors that bind to the metal ion-dependent adhesion site of the beta(2) I-like domain and prevent i

228 Simvastatin targets the metal ion-dependent adhesion site of the open, ligand-binding conformation o

229 ng of receptor and accumulating actin at the adhesion sites of beads to HeLa cells.

230 rmed a ternary complex with ILK at the focal adhesion sites of tubular epithelial cells.

231 ical findings, kindlerin is present at focal adhesions, sites of integrin-rich, membrane-substratum a

232 The metal ion-dependent adhesion site on the I-domain of LFA-1 alpha(L) subunit

233 the presence of actomyosin networks and cell adhesion sites on both sides of cells, a common machiner

234 ogy and growth with the disassembly of focal adhesion sites, perhaps to organize new integrin complex

235 ule contains a canonical metal ion-dependent adhesion site, preferentially binding Mg(2+) and Mn(2+),

236 es are distinct from the metal ion-dependent adhesion site previously demonstrated to be essential fo

237 on microscopy, and fluorescence staining for adhesion site protein expression and actin filament arch

238 e-rich protein kinase C substrate, an 87-kDa adhesion site protein.

239 of the extracellular matrix and cell-matrix adhesion sites provides cells with a means of precisely

240 ions were accompanied by a decrease in focal adhesion sites, reduced actin stress fibers and a collap

241 r localization of UNC-112 to muscle integrin adhesion sites requires PAT-4.

242 Mutations in three metal ion-dependent adhesion site residues that abolish adhesion to collagen

243 e region surrounding the metal ion-dependent adhesion site, resulting in a collagen VI network contai

244 We propose that stress fiber assembly at the adhesion site serves as a structural template that facil

245 ith cortical actin, stress fibers, and focal adhesion sites, sites of potential interaction between m

246 etal adaptor highly enriched in the integrin adhesion sites, strongly interacts with the same region

247 defective farnesylation mislocalizes nascent adhesion sites, suggesting that LKB1 farnesylation serve

248 necting myosin motors with the initiation of adhesion sites, suggesting that the major functions driv

249 y integrin complexes localized at the muscle adhesion sites termed costameres.

250 r matrix (ECM) through integrin receptors at adhesion sites termed point contacts.

251 residues surrounding the metal ion-dependent adhesion site that caused the greatest loss of collagen

252 (IV) At the surface of cells are specific adhesion sites that determine how all cells bind to each

253 constitutes an essential component of muscle adhesion sites that is regulated by RNF-5.

254 discrete plasma membrane foci known as focal adhesions, sites that anchor the intracellular actin cyt

255 l cells, which are co-clustered at fibrillar adhesions, sites that are involved in fibronectin matrix

256 s surrounding the MIDAS (metal ion-dependent adhesion site), the presumed business end of the domain.

257 ly of multiple protein interactions at focal adhesion sites, these proteins activate signaling cascad

258 sses of phosphorylated residues are found at adhesion sites-those induced by adhesion and those const

259 ruit cadherins to the nectin-based cell-cell adhesion sites through their cytoplasm-associated protei

260 residues are part of the metal ion-dependent adhesion sites, thus a metal ion-dependent adhesion site

261 form polarized bundles that connect the new adhesion site to the cells' microtubule-organizing centr

262 spatially regulates integrin endocytosis at adhesion sites to control cell migration.

263 Caveolin and uPAR may operate within adhesion sites to organize kinase-rich lipid domains in

264 ngle filaments, must polymerize outward from adhesion sites to push membranes towards distant sites o

265 protein is able to form tight intercellular adhesion sites under adverse environmental conditions.

266 grin mobility at the whole cell level and in adhesion sites under different mechanical constraints.

267 own as a mechanoeffector, it is recruited to adhesion sites under force via mechanotransducers talin

268 P2/3-controlled formation of new VE-cadherin adhesion sites via intermittently appearing lamellipodia

269 ombinatorial activation implies that at cell adhesion sites vinculin is a coincidence detector awaiti

270 f this complex from cell-matrix to cell-cell adhesion sites was required for the establishment of con

271 activated ion channels and the detachment of adhesion sites were prerequisites for this retraction.

272 s at cell-cell and cell-extracellular matrix adhesion sites, where it is thought to provide a link to

273 for the actin-myosin machinery and discrete adhesion sites which can be in a "gripping" or "slipping

274 attachment to the cell membrane at cellular adhesion sites, which is crucial for processes such as c

275 nction and recruit integrin-linked kinase to adhesion sites, which leads to Merlin degradation, downr

276 and facilitate formation of new VE-cadherin adhesion sites, which quickly move into the junctions, d

277 septal annuli, a discontinuous periplasm and adhesion sites, whilst the cytoplasmic membrane is proba

278 Force-regulation by substrate rigidity of adhesion sites with fixed area is not possible for stati

279 the full hydrodynamic load is applied to the adhesion site within an exceptionally short time-less th

280 c was dependent upon the metal ion-dependent adhesion site within the alpha(E) A domain.

281 s, cells round up and utilize the interphase adhesion sites within the fibrous extracellular matrix (

282 lly constrained mimetics of the laminin cell-adhesion site, YIGSR, are described.