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2 These data suggest that sialidases promote adipose and liver inflammation in response to a high-fat
4 ndependently of anorexia, leading to reduced adipose and muscle mass and function in tumor-bearing mi
5 macrophages, neutrophils also accumulate in adipose and muscle tissues during high-fat diets and con
7 er autophagy plays a role in alcohol-induced adipose atrophy and how altered adipocyte autophagy cont
9 ine + citrulline, +29%; P=2.8x10(-169)), and adipose browning (12,13-dihydroxy-9Z-octadecenoic acid +
10 L-10 regulates basic processes of neural and adipose cells and how it promotes CD8 T cell activation,
13 gh its varied secretome that targets distant adipose depots, skeletal muscle, and the nervous system.
14 g on a soft matrix (soft priming) will delay adipose-derived stem cell (ASC) transition to a pro-fibr
15 oring TM function and normalizing IOP, human adipose-derived stem cells (ADSCs) were induced to diffe
21 and disease and highlights emerging roles of adipose FABP (A-FABP) and epidermal FABP (E-FABP) in the
22 iated variants within the FAM13A locus alter adipose FAM13A expression, which in turn, regulates adip
23 e accumulation of the additives in liver and adipose fat of 91 to 120,000 times the rate from the nat
26 R agonist mirabegron, which stimulates beige adipose formation in subcutaneous white adipose tissue (
27 ssue (eg, liver, brain), whereas others (ie, adipose, heart) have considerable transcriptomic overlap
28 he main known features of lipoedema, such as adipose hypertrophy, dysfunction of blood and lymphatic
29 tochondrial oxidants as a unifying driver of adipose insulin resistance, serving as a signal of nutri
31 We further validated the functions of 3 new adipose IR genes by overexpression-based phenotypic resc
35 uced interferon-gamma expression and induced adipose leptin expression via increased miR181b-5p and m
37 and the deletion of Pdgfra in developmental adipose lineage disrupted white adipose tissue (WAT) for
39 uch a scenario could progressively attenuate adipose mass and function, giving rise to "lipodystrophy
41 dipose tissue (BMAT) comprises >10% of total adipose mass, yet unlike white or brown adipose tissues
43 Here, we report that inducible deletion of adipose OGT causes a rapid visceral fat loss by specific
45 ing performance and upregulated muscular and adipose Pgc-1alpha transcript levels, whereas exercise a
48 we first outline the established reciprocal adipose-SNS relationship comprising the neuroendocrine l
49 matrix production and lipid accumulation in adipose stem cells and/or adipocytes as observed in vivo
50 n mice, the serous surface of the mesenteric adipose streaks contains lymphocyte-rich organoids compr
51 on with epithelial structures and within the adipose stroma, and are important for mammary gland deve
54 sically activated M1-like phenotype in obese adipose tissue (AT) and may contribute to AT inflammatio
55 e a majority of the resident immune cells in adipose tissue (AT) and regulate both tissue homeostasis
56 h chronic low-grade inflammation of visceral adipose tissue (AT) characterized by an increasing numbe
57 llular studies RSPO3 may limit gluteofemoral adipose tissue (AT) expansion by suppressing adipogenesi
58 ng protein-4 (RBP4) is elevated in serum and adipose tissue (AT) in obesity-induced insulin resistanc
60 in insulin sensitivity due to dysfunction of adipose tissue (AT) is one of the earliest pathogenic ev
61 linemic-euglycemic clamping with concomitant adipose tissue (AT) microdialysis and an in-depth analys
63 ranscript is highly enriched in mature brown adipose tissue (BAT) and is further induced by cold and
65 nctionally competent, energy-consuming brown adipose tissue (BAT) in adult humans, much effort has be
71 lating AKG induces muscle hypertrophy, brown adipose tissue (BAT) thermogenesis, and white adipose ti
72 anisms that regulate the adaptation of brown adipose tissue (BAT), a key organ for non-shivering ther
76 inical studies have reported that epicardial adipose tissue (EpAT) accumulation associates with the p
78 minal adipose tissue (SAAT), intra-abdominal adipose tissue (IAAT), and liver fat were measured by MR
83 increased FAM13A expression in subcutaneous adipose tissue (SAT) and an insulin resistance-related p
84 nterior and posterior abdominal subcutaneous adipose tissue (SAT) depths of 1.6 and 2.0 cm, respectiv
85 e of excessive dietary fat into subcutaneous adipose tissue (SAT) prevents ectopic lipid deposition-i
86 in levels were higher in liver, subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT)
87 eige adipose formation in subcutaneous white adipose tissue (SC WAT), would induce other beneficial c
88 ned in biopsies of subcutaneous and visceral adipose tissue (SCAT and VAT, respectively) from 14 noni
89 amounts of beige cells in subcutaneous white adipose tissue (sWAT) and increased thermogenic gene exp
90 cutaneous adipose tissue (SAT), and visceral adipose tissue (VAT) in morbidly obese subjects undergoi
92 degree of unsaturation was lower in visceral adipose tissue (VAT) phospholipids, indicating lower uns
93 normalized postnatal growth, decreased white adipose tissue (WAT) and hepatic fat, improved glucose a
96 id-burning pathways in the fat-storing white adipose tissue (WAT) is a promising strategy to improve
98 recruitment of beige adipocytes in the white adipose tissue (WAT) of mice and humans, a process that
100 sity fosters low-grade inflammation in white adipose tissue (WAT) that may contribute to the insulin
101 in the adaptive metabolic response of white adipose tissue (WAT) to cold exposure (CE) in mice, expl
104 s, such as taxanes, have a high affinity for adipose tissue and a resulting higher volume of distribu
105 locomotor activity, alterations in visceral adipose tissue and hepatic development, and persistent d
107 sity MAIT cells promote inflammation in both adipose tissue and ileum, leading to insulin resistance
109 (HFD)-induced inflammation and steatosis of adipose tissue and liver are associated with a variety o
112 lumes of visceral and subcutaneous abdominal adipose tissue and liver signal intensity (LSI), a measu
113 oupling protein 1 (Ucp1) expression in white adipose tissue and protects mice from developing obesity
114 challenges associated with gene transfer to adipose tissue and report on innovations that improve ef
117 rmogenic activity of human compared to mouse adipose tissue and suggests that targeting this pathway
119 use proinflammatory macrophages recruited to adipose tissue are central to the metabolic complication
120 r axis might provide new insights into brown adipose tissue as a stress-responsive endocrine organ an
121 to variability in the amount of subcutaneous adipose tissue as the amount of visceral fat was indepen
122 ifferences in primary tumour and peritumoral adipose tissue between obese patients and those at a nor
125 ated expression of key molecules involved in adipose tissue browning and ameliorated expression of th
126 diverticulitis, PNLIP leaking into visceral adipose tissue can cause excessive visceral adipose tiss
127 onment in which adventitial and perivascular adipose tissue cells initiate and regulate important vas
133 e, we assessed the chondrogenic potential of adipose tissue derived human MSCs (hMSCs) mixed with ate
136 tic triglyceride lipase (PNLIP) increased in adipose tissue during pancreatitis and entered adipocyte
138 tail how prolonged metabolic stress leads to adipose tissue dysfunction, inflammation, and adipokine
139 y due to digestion/modification of the dense adipose tissue extracellular matrix by MMP14, thereby re
140 d), fed with a high fat diet which increases adipose tissue favouring overweight and obesity, and hou
141 tter resolve disease-specific differences in adipose tissue fibrosis compared with histologic measure
142 acids (FFAs), which were transported to the adipose tissue for storage and triggered greater insulin
145 alters genome-wide gene transcription in the adipose tissue from mother polar bears and their cubs, h
154 ration and assessed the role of peribrachial adipose tissue in determining brachial arterial distensi
157 a better understanding on the involvement of adipose tissue in wound healing, and may help to uncover
158 which GDF15 elicits a lipolytic response in adipose tissue independently of anorexia, leading to red
159 ckout [KO]) mice worsened obesity-associated adipose tissue inflammation and dysfunction, as assessed
160 activation in the context of obesity-induced adipose tissue inflammation and insulin resistance.
161 phage proinflammatory polarization, promotes adipose tissue inflammation and lipolysis, increases lip
163 in mice reduced high-fat diet (HFD)-induced adipose tissue inflammation, thereby improving adipose t
165 proaches to preserve mitochondrial function, adipose tissue integrity, and beta-cell mass during obes
166 seases, a reliable automated segmentation of adipose tissue into subcutaneous and visceral adipose ti
167 NThese data support a key pathogenic role of adipose tissue IR to increase glycerol and FFA availabil
169 ns in energy storage and energy expenditure, adipose tissue is also a dynamic endocrine organ that se
176 ached caveolae were found in brown and white adipose tissue lacking EHD2, and increased caveolar mobi
177 expression of MMP14 in the established obese adipose tissue leads to enlarged adipocytes and increase
178 food consumption and fat mass, and increased adipose tissue leptin mRNA expression in HFD-treated rec
179 med by the impaired food restriction-induced adipose tissue lipid mobilization in CT-1 null mice.
180 enocyte Pvf1 signaling inhibits expansion of adipose tissue lipid stores as the process reaches compl
181 adipose tissue can cause excessive visceral adipose tissue lipolysis independently of adipocyte-auto
184 er, the metabolic programs that characterize adipose tissue macrophages (ATM) in obesity are poorly d
185 t drives specific metabolic reprogramming of adipose tissue macrophages, contributing to the inductio
186 ls of chimerism showed a significantly lower adipose tissue mass than animals with high levels of chi
190 en the clear cell RCC tumour and peritumoral adipose tissue microenvironment might have clinical rele
195 y of dual positive gammaH2AX & p16 nuclei in adipose tissue of OSA patients receiving statin, aspirin
196 dietary surveys and/or LA concentrations in adipose tissue or blood compartments) with mortality fro
197 , IL-1R(-/-) mice have more severe liver and adipose tissue pathology during acute infection, consist
198 id (CA) on metabolic risk factors, liver and adipose tissue pathology, brain function, structure (by
201 optogenetics stimulation in the subcutaneous adipose tissue potently activates Ca(2+) cycling fat the
202 hat the severe osteopenia and the changes in adipose tissue present in these mice were mediated by in
203 r injury and dysfunction of the perivascular adipose tissue promote expansion of the vasa vasorum, ac
205 Body contouring achieved via subcutaneous adipose tissue reduction has notably advanced over the p
211 onic leptin treatment of ob/ob mice restores adipose tissue sympathetic innervation, which in turn is
212 ly compacted leaf-like part connected to the adipose tissue that can also efficiently bind B cells an
213 nergic receptor (beta-AR) potently stimulate adipose tissue thermogenesis and increase whole-body ene
214 Nonshivering thermogenesis occurs in brown adipose tissue to generate heat in response to cold ambi
216 investigated sex differences in subcutaneous adipose tissue transcriptional regulation using omic-sca
217 ) is transcriptionally up-regulated in brown adipose tissue upon exposure to the cold and suppresses
218 he plasticity of sympathetic architecture of adipose tissue via a top-down neural pathway that is cru
221 pendently associated with larger pericardial adipose tissue volume and to explore possible HIV-specif
224 d to regional differences in associations to adipose tissue volumes in upper versus lower body, and d
225 ogenase onto the MB-SPCE surface; samples of adipose tissue were analysed using the biosensors in con
227 eutrality promotes the infiltration of white adipose tissue with mast cells that are highly enriched
229 investigated associations between abdominal adipose tissue, alterations in kynurenine pathway of try
230 l fat mass at DXA, visceral and subcutaneous adipose tissue, and liver and pancreatic fat at MRI.
232 -cost technology for reducing and contouring adipose tissue, and present ECLL as a potential new appl
233 increased elastic modulus, is enhanced in DM adipose tissue, and suggest that measures of tissue mech
234 enome of hMSCs derived from the bone marrow, adipose tissue, and umbilical cord blood without alterin
235 aining increases overall miRNA expression in adipose tissue, and up-regulation of miR-203-3p limits g
236 tin slowly increases SNA to muscle and brown adipose tissue, because it induces the expression of its
237 ealed increased hydroxyproline content in DM adipose tissue, but no difference in Sirius Red staining
238 ministration reverses these abnormalities in adipose tissue, but the underlying mechanism remains to
241 ight loss with specific losses of muscle and adipose tissue, is driven by reduced food intake, increa
242 everal traits (body mass index, subcutaneous adipose tissue, low-density lipoproteins and total chole
244 sis in major metabolic organs, including the adipose tissue, skeletal muscle, and liver by 9 weeks po
245 me metabolites were found in both plasma and adipose tissue, such as the bile acid derivative deoxych
246 Although Sik2 is highly expressed in brown adipose tissue, the male and female Sik2(S587A) mice tha
247 verexpressing MMP14 in the early-stage obese adipose tissue, the transgenic mice showed a healthier m
248 oedema is an oestrogen-dependent disorder of adipose tissue, which is triggered by a dysfunction of c
249 ondrial metabolism in both fly and mammalian adipose tissue, which likely contributes to the health-
250 at vary by BMI in the tumour and peritumoral adipose tissue, which might contribute to the apparent s
251 allowing controlled substrate utilization in adipose tissue, which, in turn, supports skeletal muscle
252 s to novel roles for FST, PEPD, and PDGFC in adipose tissue, with consequences for cardiometabolic di
253 high risk if they have an excess of visceral adipose tissue-a condition often accompanied by accumula
254 neuroendocrine loop facilitated primarily by adipose tissue-derived leptin and SNS-derived noradrenal
256 s the accumulation of T cells and B cells in adipose tissue-including plasma cells that express immun
257 t might be beneficial include a reduction in adipose tissue-mediated inflammation and pro-inflammator
258 ng multielectrode arrays showed that cardiac adipose tissue-secreted factors slowed conduction veloci
259 the metabolic subsequences, we generated an adipose tissue-specific DRP1 knockout model (Adipo-Drp1(
276 or each SD increment in LA concentrations in adipose tissue/blood compartments were 0.91 (95% CI: 0.8
277 ion of Hif1alpha on cDCs results in enhanced adipose-tissue inflammation and atherosclerotic plaque f
278 ith increased DFA storage in intra-abdominal adipose tissues (r = -0.79, P = 0.05) and reduced DFA sp
279 otal adipose mass, yet unlike white or brown adipose tissues (WAT or BAT) its metabolic functions rem
280 lipid networks in visceral and subcutaneous adipose tissues and suggests an integrative pathway, wit
281 ition affect the physiological activities of adipose tissues and their dysfunctions, which lead to se
282 st body weight gain and induction of UCP1 in adipose tissues associated with dietary protein restrict
286 cant phenotype in the subcutaneous and brown adipose tissues of KO mice, with greater vascularity and
288 ces in the metabolic infrastructure of the 2 adipose tissues that may have functional and nutritional
289 g molecules for regulating glucose uptake in adipose tissues upon insulin stimulation, and this regul
290 btbd2 accumulate p85alpha in white and brown adipose tissues, causing insulin resistance, moderate ra
298 es, notably proline dehydrogenase (POX), and adipose triglyceride lipase (ATGL), as well as markedly
299 enesis by increasing the activity of hepatic adipose triglyceride lipase, intrahepatic lipolysis, hep