ライフサイエンスコーパス: administer orally

1 wed a markedly reduced gastric toxicity when administered orally.

2 Drugs were administered orally.

3 adjuvant for regional analgesia but not when administered orally.

4 (900 mg once per day) or 8 weeks of placebo administered orally.

5 ydrolysed by endogenous proteases and may be administered orally.

6 nificantly improved, compared to parent drug administered orally.

7 op live, attenuated HAV vaccines that can be administered orally.

8 tment with succimer, a lead chelator that is administered orally.

9 d mucosal and systemic lymphoid tissues when administered orally.

10 kg), a glycogen phosphorylase inhibitor, was administered orally.

11 sessed the desired detrusor selectivity when administered orally.

12 Both drug regimens were administered orally.

13 otulinum neurotoxin serotype A is toxic when administered orally.

14 ophilic drugs are often poorly absorbed when administered orally.

15 gastrointestinal and systemic immunity when administered orally.

16 rom this class of TFMKs were not active when administered orally.

17 and intestinal antibody responses than VLPs administered orally.

18 triene formation with an ED50 = 7 mg/kg when administered orally.

19 and the spontaneously hypertensive rat when administered orally.

20 ognition was measured with 6 cognitive tests administered orally.

21 y in the Plasmodium berghei mouse model when administered orally.

22 st in developing small molecules that can be administered orally.

23 rge volumes of enteric contrast material are administered orally.

24 can CNS penetration, 200 mg/kg gefitinib was administered orally 1 hour before 4 mg/kg topotecan i.v.

25 Pioglitazone (30 mg/kg weight) was administered orally 1.5 h before and 2 h after the initi

26 Rapamycin administered orally (1 mg/kg per d for 7 d) significantl

27 l occurred when 2 x 10(6) corneal cells were administered orally 10 days before orthotopic corneal tr

28 Ivosidenib was administered orally (100 mg twice daily to 1,200 mg once

29 (relaxation group), and 0.5-mg of alprazolam administered orally 15 minutes before CNB (medication gr

30 Two days later, 400 mg of ketoconazole was administered orally 2 hr before to the morning dose.

31 Biotin was administered orally (2.1, 8.2, or 81.9 micromol) or intr

32 Acalabrutinib was administered orally 200 mg once daily, or 100 mg twice d

33 sion of the NGF receptor-IR elements, C3 was administered orally (25 mg/kg, once a day), by gavage, 7

34 Latrepirdine (20 mg) vs matching placebo administered orally 3 times daily for 26 weeks.

35 yelodysplastic syndromes (MDS), MGCD0103 was administered orally 3 times weekly without interruption.

36 TMZ was administered orally 30 minutes after completion of each

37 tivity on bladder smooth muscle in vivo when administered orally (31, ED(50) = 3 mg/kg) in a rodent m

38 d in diabetic subjects only when glucose was administered orally (37.8 +/- 14.9 vs 68.3 +/- 22.8 nmol

39 Treatment was administered orally 5 d/wk for 3 months.

40 ZD6169 (5 mg/kg), administered orally 5 h prior to stimulation, significan

41 PN401 was administered orally 8 hours after 5-FU administration, t

42 Acyclovir or a matched placebo was administered orally, 800 mg five times daily, for 21 day

43 Treatments were administered orally, 801 mg or 399 mg three times a day.

44 A-988315 (20 or 60 mg/kg) or water was administered orally 90 min before retention testing, fol

45 domized to receive 8 weeks of valganciclovir administered orally (900 mg once per day) or 8 weeks of

46 However, when administered orally, A-784168, with good CNS penetration

47 None of the 3 isoflavonoid compounds administered orally affected liver alcohol dehydrogenase

48 Contrast media were administered orally and by means of an enema.

49 All drugs were administered orally and doses varied by drug combination

50 ent lack of cardiovascular side effects when administered orally and high affinity (K(i) of 36 nM for

51 Zinc stable isotopes were administered orally and intravenously.

52 ncipal adverse event observed when 2-CdA was administered orally and IV.

53 Peanut or placebo (oat) flour was administered orally and participants and the study team

54 tive high-affinity FXR inhibitor that can be administered orally and prevents, or reverses, high-fat

55 HPV-16 and HPV-18 VLPs are immunogenic when administered orally and that oral coadministration of th

56 e characteristics of clinical use (low doses administered orally and titrated for therapeutic effects

57 All interventions were administered orally and were given for 3 months after di

58 other genotypes may also be immunogenic when administered orally and whether mucosal adjuvants can be

59 rine lymphoid tumors (even when the drug was administered orally) and against human breast and bladde

60 ing 48Ca administered intravenously and 46Ca administered orally, and measuring 48Ca, 46Ca, and 42Ca

61 acute exacerbation of COPD low-dose steroids administered orally are not associated with worse outcom

62 mor activity in murine xenograft models when administered orally as a lipid-based formulation or impl

63 eated with azithromycin at a dosage of 2.0 g administered orally as a single dose with cure rates for

64 in the rat, dog, and cynomolgus monkey when administered orally as a solution formulation.

65 (13)C-glycerol tripalmitin was administered orally as an independent measure of CM TAG

66 Of these 16 new anilides administered orally as one 6 mg/kg dose combined with 18

67 VP-16 was administered orally as repeated 21-day courses at 50 mg/

68 Immunosuppressants were administered orally as single daily doses.

69 of human tumor xenografts in nude mice when administered orally as single-agent therapy.

70 in humans is three to five times higher when administered orally as the prodrug.

71 hritis in rats with established disease when administered orally at 0.3 and 3 mg/kg twice daily.

72 RAD was administered orally at 0.5 mg/kg per day for days 0 to 1

73 Everolimus was administered orally at 10 mg daily and letrozole was adm

74 Administered orally at 10 mg/kg the level of reversal wa

75 ced blood pressure by more than 45 mmHg when administered orally at 10 mg/kg to the spontaneously hyp

76 n thyroparathyroidectomized (TPTX) rats when administered orally at 10 mg/kg.

77 %, comparable to the effect of carbamazepine administered orally at 100 mg/kg.

78 were randomly assigned to receive ivacaftor administered orally at 150 mg (n = 26) or placebo (n = 2

79 ered orally at 10 mg daily and letrozole was administered orally at 2.5 mg daily.

80 Sildenafil (n = 79) or a placebo (n = 81) administered orally at 20 mg, 3 times daily for 12 weeks

81 Sildenafil (n = 113) or placebo (n = 103) administered orally at 20 mg, 3 times daily for 12 weeks

82 and 42 induced tumor growth inhibition when administered orally at 200 mg/kg/day.

83 During dose escalation, ivosidenib was administered orally at 200-1200 mg daily in 28-day cycle

84 Lenalidomide was administered orally at 25 mg on days 1 through 21 of a 2

85 ppressing >/= 99.8% parasitemia in mice when administered orally at 25 mg/kg, b.i.d., for 4 days.

86 Marimastat was administered orally at 25, 50, or 100 mg twice daily to

87 ethyl-2H3]methionine and [2H2]cysteine) were administered orally at 30-min intervals for 8 h.

88 Adavosertib was administered orally at 300 mg once daily on days 1-5 and

89 Sorafenib was administered orally at 400 mg twice daily on a continuou

90 Alisertib was administered orally at 50 mg twice daily for 7 days in 2

91 Prednisone or a matched placebo was administered orally at 60 mg/d for the first 7 days, 30

92 Everolimus was administered orally at a daily dose of 2.1, 3, 5, or 6.5

93 Patients received artesunate, administered orally at a daily dose of either 2 mg per k

94 stay of at least 3 days to receive apixaban, administered orally at a dose of 2.5 mg twice daily for

95 Lenalidomide was administered orally at a dose of 25 mg on days 1 to 21 o

96 Ibrutinib was administered orally at a dose of 560 and 420 mg once dai

97 When administered orally at a single 10(4) (CFU) dose, SC602

98 betic rat model for approximately 17 h, when administered orally at a single dose of 2 mg/kg/day.

99 In nonclinical studies, fidaxomicin was administered orally at approximately 1 g/kg/d to dogs fo

100 zed to receive placebo or 274 mg of ADS-5102 administered orally at bedtime for up to 25 weeks.

101 r human or nonhuman primate populations, was administered orally at doses ranging from 10(6) to 10(10

102 Drug was administered orally at escalating doses as a solution (2

103 Quizartinib was administered orally at escalating doses of 12 to 450 mg/

104 PT2385 was administered orally at twice-per-day doses of 100 to 1,8

105 n of noradrenergic and antimuscarinic agents administered orally before bedtime on 1 night greatly re

106 ubcutaneously) and FTY720 (0.3 mg/kg per day administered orally), both administered on day -2 throug

107 virulence attenuation when the strains were administered orally but not when they were administered

108 urium fis mutant is attenuated 100-fold when administered orally, but has wild-type virulence when ad

109 olytic actions with a low bleeding risk when administered orally, but its benefit for preventing recu

110 In groups PROB and LIP/PROB, the PROB was administered orally by addition to the drinking water of

111 ce a day, or imatinib 400 mg once a day, all administered orally, by use of a computer-generated rand

112 Larotrectinib was administered orally (capsule or liquid formulation), on

113 he intravenous formulation of irinotecan was administered orally daily for 5 days for 2 consecutive w

114 Temozolomide was administered orally daily for 5 days, with subsequent co

115 Ivosidenib was administered orally daily in 28-day cycles.

116 Vorinostat was administered orally daily starting at 180 mg/m(2)/d with

117 Erlotinib was administered orally daily to groups of at least three as

118 m(2) on days 1 to 3 and etoposide 40 mg/m(2) administered orally days 1 through 14.

119 5bb administered orally demonstrated a biphasic effect on th

120 kg), a glycogen phosphorylase inhibitor, was administered orally, either alone to create mild hypogly

121 Thereafter, 80 mg/kg hydroxyurea was administered orally every 3 days.

122 Pravastatin and nicotinamide were administered orally every day for 14 days, starting on t

123 hionine aminopeptidase type 2 inhibitor, was administered orally every other day at 1, 5, or 10 mg/kg

124 Venetoclax was administered orally for 14 days each cycle.

125 Pterosin A, administered orally for 4 weeks, effectively improved hy

126 variectomy-induced bone loss in the rat when administered orally for 6 months at 10 mg/kg/d and was p

127 Citicoline (500 mg/day) was administered orally for 6 weeks, and patients were follo

128 maximum tolerated dose (MTD) of capecitabine administered orally for 7 days followed by a 7-day rest

129 PSC 833 was administered orally for 7 days, beginning 72 hours befor

130 AQX-1125 (450 mg daily) or placebo was administered orally for 7 days.

131 d different doses, we found that 3 mg of TAM administered orally for five consecutive days provides m

132 n the present phase 1 study, capravirine was administered orally for up to 28 days to 55 HIV-1-infect

133 elial cells from relevant donor strains were administered orally from day -14 to day -4 on a daily ba

134 any potential neuroprotective agent must be administered orally, have a safe profile and poses a bro

135 Both treatments were administered orally in 10 ml (increasing to 20 ml, accor

136 Alisertib was administered orally in 21-day cycles at the recommended

137 C3 was administered orally in 5, 10, and 25 mg/kg/day concentra

138 onventional antimicrobial therapy, which was administered orally in 96 percent.

139 In addition, we propose that the vaccine be administered orally in a 2-dose schedule, with the first

140 hion via subcutaneous implant, whereas P was administered orally in a cyclic fashion.

141 owth regression at well tolerated doses when administered orally in a human BT474 human breast cancer

142 4m and its efficacy and GI tolerability when administered orally in a rat adjuvant arthritis model.

143 ofile and demonstrated maximal efficacy when administered orally in a rat adjuvant arthritis model.

144 ole 6d demonstrated impressive efficacy when administered orally in a rat model of arthritis and in a

145 c disease, a range of doses (0.4-100 mg) was administered orally in a single dose before challenge.

146 e tablets were dissolved into a solution and administered orally in a single dose.

147 d possesses antiinflammatory properties when administered orally in an in vivo murine inflammation mo

148 icin and paclitaxel in xenograft models when administered orally in combination therapy.

149 When suboptimal doses were administered orally in combination to wild-type mice, IF

150 Conclusions-Heparin, administered orally in combination with the delivery age

151 limus (18 mg/day and 5 mg/day, respectively) administered orally in continuous 28-day cycles until di

152 MA 800 mg/d was administered orally in divided doses.

153 WAY-202196 or control (vehicle) was administered orally in doses ranging from 1.5 to 50 mg/k

154 Here, we find that EGCG administered orally in drinking water (50 mg/kg) similar

155 SM16 was administered orally in formulated chow.

156 Dasatinib (15 to 240 mg per day) was administered orally in four-week treatment cycles, once

157 veral compounds that exhibited efficacy when administered orally in murine pyelonephritis and pneumon

158 When administered orally in murine xenograft models, CX-4945

159 escalations in the dose of PLX3397 that was administered orally in patients with solid tumors (dose-

160 treated with escalating doses of clopidogrel administered orally in solution until either a clinicall

161 nonreplicating rNV VLPs are immunogenic when administered orally in the absence of any delivery syste

162 Nicotine was administered orally in the drinking water to achieve ser

163 Finally, an NOS-2 inhibitor, aminoguanidine, administered orally in the drinking water, was tested fo

164 mug, 5.0 mug, or 10.0 mug), or placebo were administered orally in two doses 2 weeks apart.

165 Arimoclomol was administered orally, in drinking water, from symptom ons

166 Both drugs were administered orally, in tablet formulation.

167 VLPs administered orally induced serum antibody and intestina

168 Boldine, administered orally, inhibited the alveolar bone resorpt

169 Oseltamivir (GS4104), which can be administered orally, is the prodrug of GS4071, a potent

170 a favorable risk-to-benefit ratio when it is administered orally long-term to patients with the pruri

171 When administered orally, LY333531 ameliorated the glomerular

172 When administered orally, mastic oil inhibited the growth of

173 Palbociclib 125 mg/d was administered orally on a 21-days-on, 7-days-off schedule

174 cobalamin deficiency, 2 mg of cyanocobalamin administered orally on a daily basis was as effective as

175 dose for disease-directed studies of OSI-774 administered orally on a daily, continuous, uninterrupte

176 ydrogenase, allows fluorouracil (5-FU) to be administered orally on a schedule that simulates continu

177 Melphalan and prednisone were administered orally on days 1 to 4; carfilzomib was IV a

178 CHOP intravenously on day 1 (with prednisone administered orally on days 1 to 5) or VR-CAP (R-CHOP re

179 Dexamethasone 40 mg daily was administered orally on days 1, 8, 15, and 22 of each cyc

180 ither olaparib (200 mg capsules twice daily, administered orally on days 1-10 of each 21-day cycle) p

181 Therapy was administered orally on the first 5 days of a 28-day cycl

182 thasone (20 mg [10 mg if age >75 years]) was administered orally on the same days as bortezomib and t

183 Temodar was administered orally once a day for five consecutive days

184 LGD1069 administered orally once daily at doses that ranged from

185 COL-3 was administered orally once daily at one of two doses (grou

186 of five dose cohorts of lapatinib (GW572016) administered orally once daily continuously.

187 Darapladib 160 mg or placebo monotherapy was administered orally once daily for 3 months, and patient

188 pidermal growth factor receptor (EGFR), when administered orally once daily on an intermittent-dose s

189 Sunitinib (25, 37.5, or 50 mg) was administered orally once daily on three dosing schedules

190 Erlotinib was administered orally once daily to cohorts of three to si

191 COL-3 administered orally once daily to patients with AIDS-rel

192 ose levels of voxelotor (1500 mg and 900 mg, administered orally once daily) with placebo in persons

193 COL-3 was administered orally once daily, and doses were escalated

194 ing mortality using doses of 5 to 1.25 mg/kg administered orally once daily, even when treatments wer

195 Pazopanib 800 mg was administered orally once daily.

196 cancer with 125 mg of motesanib diphosphate, administered orally once daily.

197 (Ocean Spray, Lakeville-Middleboro, MA) and administered orally once per day for 5 days every 3 week

198 Valganciclovir administered orally once per day is well tolerated and s

199 th extracranial solid tumors is 12 mg/m(2)/d administered orally, once daily, continuously.

200 LCL161 was administered orally, once weekly, on a 21-day cycle to a

201 ntipsychotic efficacy in a controlled trial, administered orally open-label once daily in the morning

202 tion of diatrizoate meglumine and sodium was administered orally or by means of a nasogastric tube as

203 es weeks of antibiotic therapy, which can be administered orally or intravenously via a peripherally

204 filter to detoxify chemicals and metabolite administered orally or intravenously.

205 Mouse studies indicate that caffeine, administered orally or topically, promotes apoptosis of

206 ither eukaryotic cells or model animals when administered orally or topically.

207 xotoxin A (SPEA) did not cause symptoms when administered orally or vaginally.

208 Sertraline was administered orally or via nasogastric tube at a dose of

209 All-trans retinoic acid administered orally (oral ATRA) may not regularly lead t

210 tients underwent active AMPT (five 1-g doses administered orally over 28 hours) and placebo (diphenhy

211 Vitamin C at a dose of 1.25 g administered orally produced mean (+/-sd) peak plasma co

212 wn that this novel formulation of AmB can be administered orally, resulting in 99% inhibition of para

213 ant number (N = 34) of these macrocycles are administered orally, revealing that oral bioavailability

214 BALB/c mice administered orally serovar Typhimurium chi4550 expressi

215 ates remodeling to a larger extent than when administered orally shortly after reperfusion.

216 low bioavailability of bisphosphonates when administered orally, subsequent studies tested the mice

217 terone metabolites 1 and 2 are inactive when administered orally, suggesting that 3 beta-substitution

218 Eltrombopag is a TPO nonpeptide mimetic administered orally that activates the TPO receptor by b

219 We found that when administered orally, the control virus was far more viru

220 ere also markedly altered; for example, when administered orally, the maximum plasma concentration fo

221 When administered orally, these new carboxyphenyltrioxanes ar

222 Dipyridamole 75 mg was administered orally three times daily during the FU admi

223 ears or older were treated with mocetinostat administered orally three times per week, in 28-day cycl

224 -escalation phase (n = 47), panobinostat was administered orally thrice weekly every week in combinat

225 isted of FOLFOX-4 with gefitinib at 500 mg/d administered orally throughout the 14-day cycle.

226 STI571 was administered orally to 83 patients with CML in the chron

227 9-cis-Retinal was administered orally to a subset of Rpe65(-/-) mice, and

228 Moreover, AV513 administered orally to AAV-FVIII dogs and treatment-naiv

229 ective when applied topically to the skin or administered orally to affect the colon but are not effe

230 der filling, 30 mL of corn oil emulsion were administered orally to all patients followed by dynamic

231 nuated compared to the wild-type parent when administered orally to BALB/c mice and were less invasiv

232 groups severely attenuated the mutants when administered orally to BALB/c mice, but the mutants colo

233 virulence in the msbB mutant background when administered orally to BALB/c mice.

234 sed constitutively in Lactococcus lactis and administered orally to C57 BL/6 mice.

235 ated rotavirus vaccines lacked efficacy when administered orally to calves and pigs in the field, pre

236 clinical trials of monopreparations of CoQ10 administered orally to cancer patients were included.

237 Gefitinib (150, 300, 400, or 500 mg/m2) was administered orally to cohorts of three to six patients

238 ability to inhibit plasma ACE activity when administered orally to conscious normotensive rats.

239 kg), a glycogen phosphorylase inhibitor, was administered orally to decrease glucose output in each o

240 Rather, when administered orally to fasted mice, glucose was directed

241 Injected or administered orally to fasted or normally fed mice at th

242 Vector strains were administered orally to germfree mice that were subsequen

243 de synthesized from D-amino acids (D-4F) was administered orally to LDL receptor-null mice on a Weste

244 (3.2 mg/kg/day) and CsA (10 mg/kg/day), when administered orally to Lewis rats for 10 days (day 0-9),

245 ility was established whereby compounds were administered orally to mice and plasma levels were measu

246 TM preferentially concentrates in liver when administered orally to mice and potently inhibits hepati

247 VNI displays promising pharmacokinetics and administered orally to mice at 25 mg/kg for 30 days cure

248 ly 4F synthesized from D-amino acids (D-4F), administered orally to mice did not raise HDL-cholestero

249 , to assess its efficacy in vivo, BTKB66 was administered orally to mice for 7 days before subjecting

250 The compounds were administered orally to mice with acute T. cruzi infectio

251 50) values of 0.14 mg/kg and 0.08 mg/kg when administered orally to mice with acute toxoplasmosis.

252 Antigens were administered orally to mice, and antigen-specific genera

253 Furthermore, when administered orally to mice, ex vivo imaging of rhodamin

254 When administered orally to mice, these compounds exhibited p

255 ild-type Salmonella serovar Typhimurium when administered orally to mice, while the PmrA-regulated ge

256 mately 5-fold increased 50% lethal dose when administered orally to mice.

257 ARRY-063 was administered orally to ovalbumin (OVA) sensitized and ch

258 toxicity and good antimalarial activity when administered orally to P. berghei -infected mice.

259 Lorlatinib was administered orally to patients at doses ranging from 10

260 emic and hypotriglyceridaemic responses when administered orally to rat and dog.

261 ive P2X3 and P2X2/3 receptor antagonist, was administered orally to rats and found to produce highly

262 d that also contained two chlorine atoms was administered orally to rats, and samples of bile, urine,

263 or growth delay at well tolerated doses when administered orally to SCID mice implanted with PTEN-def

264 doses of egg white or ovomucoid as OIT were administered orally to sensitized mice.

265 Elacridar and cold erlotinib were administered orally to wild-type (WT) and Abcb1a/b;Abcg2

266 opotecan in combination with ABT-888 (10 mg) administered orally twice a day (BID) were evaluated.

267 ce a day on days 1 to 28 and abexinostat was administered orally twice a day on days 1 to 5, 8 to 12,

268 Patients and Methods MK-8242 was administered orally twice a day on days 1 to 7 in 21-day

269 lacebo, tofacitinib at 1, 3, 5, 10, or 15 mg administered orally twice a day, or adalimumab at 40 mg

270 ratio, to four regimens: 5 mg of tofacitinib administered orally twice daily (132 patients); 10 mg of

271 During dose escalation, rogaratinib was administered orally twice daily at 50-800 mg in continuo

272 Lonafarnib was administered orally twice daily at dose levels of 70, 90

273 Lapatinib was administered orally twice daily at escalating doses star

274 ctive) and appropriate placebo solution were administered orally twice daily for 12 months, and child

275 ylcysteine 1200 mg or matching placebo) were administered orally twice daily for 2 doses before and 2

276 levels of 50, 65, 85, and 110 mg/m(2)/dose, administered orally twice daily for 28 days, with course

277 Imatinib mesylate administered orally twice daily for AIDS-related KS resu

278 ecitabine (825, 1,000, or 1,250 mg/m(2)) was administered orally twice daily on days 1 to 14 every 3

279 ) or control (capecitabine 1000 mg/m(2) self-administered orally twice daily on days 1-14 on each 21-

280 study groups, 5.0 mg/kg of cyclosporine was administered orally twice daily starting 3 days before H

281 ase 2 open-label study, 400 mg nilotinib was administered orally twice daily to 280 patients with Phi

282 ML120B was administered orally twice daily, either prophylactically

283 1:1 ratio, to receive 150 mg of nintedanib, administered orally twice daily, or placebo.

284 ays to receive either 100 mg of minocycline, administered orally twice daily, or placebo.

285 AZD1775 was administered orally twice per day over 2.5 days per week

286 Ibrutinib at a daily dose of 420 mg was administered orally until disease progression or the dev

287 tment followed by 2 weeks without treatment) administered orally until disease progression or unaccep

288 Allogeneic dendritic cells (DC) were administered orally using a protocol that is known to re

289 tenuated recombinant Listeria monocytogenes, administered orally utilizing its natural route of infec

290 fficacy of azithromycin at a dosage of 2.0 g administered orally was equivalent to that of benzathine

291 opiridol had a similar activity in vivo when administered orally, we examined neointimal formation in

292 , and antiviral effects of ganciclovir (Gcv) administered orally were evaluated in 36 children infect

293 Low doses of CMC2.24 (1 mg/kg/day) administered orally were sufficient to significantly inh

294 70Zn and dysprosium were administered orally with all meals for 5 consecutive day

295 Axitinib or placebo were administered orally with food at a starting dose of 5 mg

296 taste-masked preparation of SNAC 2.25 g was administered orally with heparin 30000 to 150000 IU.

297 eogenic gene expression in the liver of mice administered orally with metformin.

298 Temozolomide was administered orally within 60 minutes of the end of the

299 In mice, these VLPs are immunogenic when administered orally without adjuvant, and they elicit se

300 Such a hybrid vaccine, administered orally, would stimulate immune responses bo