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1 acyl-enzyme intermediate so that the mutant adopts a conformation analogous to that of the acyl-enzy
2 ), together with its 2',3'-cyclic phosphate, adopts a conformation close to and approximately perpend
3 (2+) and SNAP25 to bind the plasma membrane, adopting a conformation compatible to interact with the
5 icating that calcium binding results in LapG adopting a conformation competent for interaction with t
6 m66, the N-terminal region of the gp41 MPER adopts a conformation comprising a helix, followed by an
7 the structural features of the receptor that adopt a conformation different from that observed in the
8 at at acidic pH, the PhoQ periplasmic domain adopts a conformation different from that in the presenc
10 ear magnetic resonance (NMR) spectroscopy to adopt a conformation distinct from that seen in crystals
12 esting that Glu-plasminogen on cell surfaces adopts a conformation distinct from that in solution.
13 n via the UFL1 subunit of E3(UFM1), and UFL1 adopts a conformation distinct from that previously obse
14 itivity and inhibition by luminal Ca(2+) and adopts a conformation distinct from the activated state
15 nd shape of the template anions, dynamically adopting a conformation either where all four azaphospha
16 II suppressor mutations induce Switch II to adopt a conformation favorable for nucleotide binding an
18 s reveal LRP2 to be a molecular machine that adopts a conformation for ligand binding at the cell sur
19 advantageous for the polyprenol phosphate to adopt a conformation in the same leaflet where the monot
20 s controlled by the ability of the latter to adopt a conformation in which carbonyl groups are almost
21 e form of the ribozyme-substrate complex can adopt a conformation in which helices 2 and 3 are coaxia
22 ificant proportion of HIV-1 MA molecules may adopt a conformation in which myristic acid is hidden an
23 her TF family members and (2) the N-lobe can adopt a conformation in which the cleft closes when iron
24 The compounds with an axial phenyl commonly adopt a conformation in which the plane of the aromatic
25 , and it showed that the ouabain derivatives adopt a conformation in which the sugar extends out of t
26 MR data (1) demonstrate that Abeta(1)(-)(40) adopts a conformation in amyloid fibrils with two in-reg
28 ntrast, the PKB-selective inhibitor A-443654 adopts a conformation in PKB and PKA-PKB that differs fr
29 ation also implies that the acetylenic chain adopts a conformation in which a significant interaction
31 w that 1) newly synthesized protein kinase C adopts a conformation in which its pseudosubstrate seque
32 summary, newly synthesized protein kinase C adopts a conformation in which its pseudosubstrate seque
34 STAT2, whereby the semiphosphorylated dimers adopted a conformation incapable of importin-alpha bindi
35 uctural studies indicate that the C1 complex adopts a conformation incompatible with intramolecular a
36 luble mutants refolded from inclusion bodies adopted a conformation inherent to the wild-type N(t)-FD
37 suggesting that the anchor-minus ectodomain adopts a conformation largely similar to the postfusion
39 itands are conformationally flexible, always adopting a conformation locating the phenyl substituents
41 eaded through the RNA exit channel, where it adopts a conformation mimicking that of a single strand
42 sts that the protease binding loop of ecotin adopts a conformation mimicking that of the cleaved stra
43 , in contrast to the free protein, Y35G BPTI adopts a conformation nearly identical with that of the
45 e FMN is reduced to the semiquinone form and adopts a conformation ("O-up") in which O 58 hydrogen bo
47 s their membrane affinity and causes them to adopt a conformation on membranes that is similar to the
49 consisting in part of Asp168-Phe169-Gly170, adopts a conformation permitting lipophilic and hydrogen
50 at, compared to R132H, the R132Q active site adopts a conformation primed for catalysis with optimize
51 ide of the nucleosome, where it subsequently adopts a conformation productive for DNA translocation.
52 ent behavior of His-143 in which the residue adopts a conformation proximal to the site of catalytic
54 oligomerization, and the resulting oligomers adopt a conformation representing a state of reduced act
55 lutaraldehyde-fixed rat brain sec6/8 complex adopts a conformation resembling the letter "T" or "Y".
56 ckbone flexibility of the switch loop, which adopted a conformation restricting the pathway toward th
57 eing partially inserted into beta-sheet A to adopt a conformation similar to an intermediate on the p
58 the asymmetric unit that are bound to FliM16 adopt a conformation similar to BeF3- -activated wild-ty
59 e stabilize the integrin-bound conformation, adopt a conformation similar to earlier-evolving family
60 cellular ends of helices 3 and 6 together to adopt a conformation similar to that found in inactive r
61 e coat protein has an enhanced propensity to adopt a conformation similar to that found in the native
62 axial phenyl group at C(5) of 1,3-dioxane to adopt a conformation similar to that in axial phenylcycl
63 side chains, with two methylene groups, can adopt a conformation similar to that of Pro side chains,
64 uses sigma(32) to initiate transcription can adopt a conformation similar to that of sigma(70)-contai
65 re prediction suggest that Cdh23 ectodomains adopt a conformation similar to the classic cadherins.
66 gly (although not as well as the wild type), adopted a conformation similar to that of the wild type.
68 to the M2R seven-transmembrane bundle, which adopts a conformation similar to that in the M2R-heterot
69 P-70 reveals that the inactive kinase domain adopts a conformation similar to that of cyclin-dependen
71 ral analysis showed that SUV3-83, at pH 5.0, adopts a conformation similar to that of SUV3-70, sugges
72 dynamics simulations, the fCS repeating unit adopts a conformation similar to that of the Le(x) blood
73 tion, we find that the EGFRK activation loop adopts a conformation similar to that of the phosphoryla
75 ral change that affects a mobile loop, which adopts a conformation similar to that seen in complexes
76 NA ASL indicate that the threonyl side chain adopts a conformation similar to that seen in the soluti
77 the Sec4-GDP crystals, the switch II region adopts a conformation similar to that seen in the struct
78 thered Rad4 flips out normal nucleotides and adopts a conformation similar to that seen with damaged
80 ructure of an AM-8138.COX-2 complex, AM-8138 adopts a conformation similar to the unproductive confor
81 the guanine at the N7 position permits it to adopt a conformation such that the Hoogsteen face of the
82 analysis showed that the GCAP1-I143NT mutant adopted a conformation susceptible to proteolysis, and t
83 usual overall architecture that allows it to adopt a conformation that appears to facilitate pairwise
84 tic activity of Sos by forcing the domain to adopt a conformation that destabilizes the autoinhibitor
85 non-denaturing gels) that TR-T(4) complexes adopt a conformation that differs from TR-T(3) complexes
86 on K252 and allowing tubulin heterodimers to adopt a conformation that disfavors tubulin incorporatio
87 egions within or surrounding the active site adopt a conformation that favors enhanced enzymatic acti
88 on enables the monomethyllysyl side chain to adopt a conformation that is catalytically competent for
90 is that the A and B rings of aminoglycosides adopt a conformation that is recognized not only by the
91 ng to greater flexibility and the ability to adopt a conformation that minimizes steric clashing and
92 , the omega-aminoalkyl side chains prefer to adopt a conformation that points them toward the 3'-base
95 3-580) in the zymogen serine protease domain adopt a conformation that would be predicted to sterical
96 eover, as the temperature was lowered, Tyr31 adopted a conformation that more effectively blocked the
97 g revealed that the CYP17 inhibitor-bound AR adopted a conformation that resembled the unliganded AR
98 tive site cavity, is partially disordered or adopts a conformation that allows access to the cavity.
102 ropose that ParB(F) in the partition complex adopts a conformation that enhances ParB(F)-ParB(F) and
103 es indicate that the (S)-nucleotide backbone adopts a conformation that has little impact on the over
105 t in many cases, the inhibitor-bound protein adopts a conformation that is distinct from its unbound
107 DNA contacts in the DNA-bound structure, it adopts a conformation that is incompatible with DNA bind
108 5'-imidotriphosphate-bound form, this mutant adopts a conformation that is intermediate between the G
110 on during activated catalysis, whereas K335Q adopts a conformation that is resistant to trypsin cleav
112 ructure, the characteristic UCU bulge of TAR adopts a conformation that is stabilized by three divale
113 rystallographic analysis: The remodeled loop adopts a conformation that is within 1-A Calpha RMSD of
114 eoselective provided that the carbonyl group adopts a conformation that leads to one face being compl
115 Upon lysine binding, the lysC riboswitch adopts a conformation that not only inhibits translation
118 ed in other alanine racemase structures, PLP adopts a conformation that significantly distorts the pl
119 In the NADP(+)-free structure, the loop adopts a conformation that sterically hinders NADP(H) bi
120 in revealed that the (1248)SFYYS(1252) motif adopts a conformation tightly packed against the kinase
123 ex with ATP reveals that the gamma-phosphate adopts a conformation unique among Fic domains that seem
124 Mutants missing this buried 30-51 disulfide adopt a conformation very similar to that of the native
125 the modeling of a NifEN-bound "FeMoco" that adopts a conformation very similar to that of the MoFe p
126 stance where a bithiophene has been shown to adopt a conformation where the sulfur atoms are complete
127 reveal this region to be dynamic and able to adopt a conformation where U-1 is stacked with G33.
128 ranes lacking cholesterol and anionic lipids adopts a conformation where agonist binding is uncoupled
129 stal structures showed that the dppms ligand adopts a conformation which creates a sterically crowded
130 ogical conditions, both zymogen and protease adopt a conformation with all domains vertically aligned