ライフサイエンスコーパス: adrenal insufficiency

1 lue, and 3mug/dL or less is considered to be adrenal insufficiency.

2 d-free immunosuppression were diagnosed with adrenal insufficiency.

3 y failure, hypotension) was used to diagnose adrenal insufficiency.

4 og) cosyntropin was considered diagnostic of adrenal insufficiency.

5 differ significantly (P > 0.5) for secondary adrenal insufficiency.

6 ticularly in the identification of secondary adrenal insufficiency.

7 ul diagnostic threshold for the diagnosis of adrenal insufficiency.

8 0.30 to 0.60) for the diagnosis of secondary adrenal insufficiency.

9 evaluation of suspected primary or secondary adrenal insufficiency.

10 -language papers related to the diagnosis of adrenal insufficiency.

11 reshold of <18 microg/dL, 7% (two of 28) had adrenal insufficiency.

12 entration <18 microg/dL, 21% (six of 28) had adrenal insufficiency.

13 nsufficiency, 50% (14 of 28) of patients had adrenal insufficiency.

14 ause different criteria are used to diagnose adrenal insufficiency.

15 y variable assessed that was associated with adrenal insufficiency.

16 at varies with the criteria used to diagnose adrenal insufficiency.

17 ed high-dose fluconazole appeared to develop adrenal insufficiency.

18 he critical illness and relative or absolute adrenal insufficiency.

19 ported to cause complete XY sex reversal and adrenal insufficiency.

20 ic-pituitary-adrenal axis, which can lead to adrenal insufficiency.

21 All 3 treatment groups led to increased adrenal insufficiency.

22 seful therapeutic strategy for patients with adrenal insufficiency.

23 TH-stimulated cortisol and high incidence of adrenal insufficiency.

24 ported in patients with primary or secondary adrenal insufficiency.

25 sterone sulfate (DHEAS) are used to diagnose adrenal insufficiency.

26 y) should be added for patients with primary adrenal insufficiency.

27 adrenal insufficiency but harms mice without adrenal insufficiency.

28 tients receiving block A treatment alone had adrenal insufficiency.

29 , paving the way for cell-based therapies of adrenal insufficiency.

30 han 500 ms, and three patients had suspected adrenal insufficiency.

31 nd impaired quality of life in patients with adrenal insufficiency.

32 ophysitis with documented hypothyroidism and adrenal insufficiency.

33 here were no cases of clinically symptomatic adrenal insufficiency.

34 to 60% of severe septic patients experience adrenal insufficiency.

35 ver toxicity, corrected QT prolongation, and adrenal insufficiency.

36 current infections, autoimmune features, and adrenal insufficiency.

37 ogen production, in addition to treatment of adrenal insufficiency.

38 aC likely contributes to the hyponatremia of adrenal insufficiency.

39 e administered to overcome etomidate-related adrenal insufficiency.

40 ia and uniformly revealed hypotension due to adrenal insufficiency.

41 on the type of lymphoma and/ or presence of adrenal insufficiency.

42 sufficiency, and 69 (88%) had either form of adrenal insufficiency.

43 lation test to diagnose absolute or relative adrenal insufficiency.

44 atory criteria for the diagnosis of relative adrenal insufficiency.

45 ill patients who are in refractory shock and adrenal insufficiency.

46 (250-microg cosyntropin test), and secondary adrenal insufficiency (1-microg cosyntropin test), respe

47 Except for increased incidence of adrenal insufficiency (12%-G1-4, 4%-G3-4), no new safety

48 ncy (250-microg cosyntropin test), secondary adrenal insufficiency (250-microg cosyntropin test), and

49 for summary ROC curves in tests for primary adrenal insufficiency (250-microg cosyntropin test), sec

50 hildren with suspected or proven "absolute"' adrenal insufficiency (2C).

51 ds only in children with suspected or proven adrenal insufficiency (2C); and a recommendation against

52 corticotropin testing, 44 (56%) had absolute adrenal insufficiency, 39 (50%) had relative adrenal ins

53 e sole diagnostic threshold for diagnosis of adrenal insufficiency, 50% (14 of 28) of patients had ad

54 is (18 [33.3%]), dermatitis (9 [16.7%]), and adrenal insufficiency (8 [14.8%]).

55 nt steroids for hypophysitis (8 [50.0%]) and adrenal insufficiency (8 [50.0%]), and 42 (45.2%) were u

56 2 demonstrated significant associations with adrenal insufficiency after correction for multiple comp

57 , which occurs in about 50% of patients with adrenal insufficiency after diagnosis.

58 The risk of developing adrenal insufficiency (AI) following adrenalectomy has b

59 Adrenal insufficiency (AI) is a condition characterized

60 In patients with cirrhosis, adrenal insufficiency (AI) is reported during sepsis and

61 lude uncommon manifestations like autoimmune adrenal insufficiency (AI), hypoparathyroidism, and chro

62 nity, most often hypoparathyroidism (HP) and adrenal insufficiency (AI).

63 eficiency, hypogonadism, hypothyroidism, and adrenal insufficiency, all graded by the modified Common

64 endent severe sepsis appear to have relative adrenal insufficiency and benefit from replacement gluco

65 only prescribed HDS to prevent perioperative adrenal insufficiency and cardiovascular collapse.

66 ssociated with hypothyroidism, while central adrenal insufficiency and diabetes insipidus occurred in

67 ufficiency but harms septic patients without adrenal insufficiency and encourage further efforts to t

68 e needed to define the risk of postoperative adrenal insufficiency and establish standardized practic

69 an nuclear receptors SF1 and DAX1 each cause adrenal insufficiency and gonadal dysgenesis in humans,

70 Our results suggest a basis for adrenal insufficiency and hypogonadotropic hypogonadism

71 enita, an X-linked disorder characterized by adrenal insufficiency and hypogonadotropic hypogonadism.

72 Therefore, the recognition of adrenal insufficiency and interventions to improve adren

73 Relative adrenal insufficiency and its clinical implications have

74 e raised in medical teams and patients about adrenal insufficiency and management of adrenal crisis t

75 ntubation is associated with higher rates of adrenal insufficiency and mortality in patients with sep

76 ty, hypogonadism and infertility, iatrogenic adrenal insufficiency and perimenopause in patients with

77 genetic syndrome of growth retardation with adrenal insufficiency and selective NK deficiency.

78 In addition, the associations between adrenal insufficiency and the CD4 count, human cytomegal

79 the current diagnostic approach to detecting adrenal insufficiency and the clinical consequences in c

80 d, discovery study, 10 subjects with primary adrenal insufficiency (and no other endocrinopathies) we

81 ), pituitary (hypophysitis), adrenal glands (adrenal insufficiency) and pancreas (diabetes mellitus).

82 adrenal insufficiency, 39 (50%) had relative adrenal insufficiency, and 69 (88%) had either form of a

83 with autosomal recessive growth retardation, adrenal insufficiency, and a selective NK cell deficienc

84 ts in a classic triad of hypoparathyroidism, adrenal insufficiency, and candidiasis.

85 er of very-long-chain fatty acid metabolism, adrenal insufficiency, and cerebral demyelination.

86 ve the quality of life in some patients with adrenal insufficiency, and further advances in oral and

87 th hormone deficiency, primary hypogonadism, adrenal insufficiency, and hypothyroidism.

88 ating to OCS use, tapering, adverse effects, adrenal insufficiency, and patient-physician shared deci

89 The lack of an adrenal insufficiency animal model and our poor understa

90 enger receptor BI mice as the first relative adrenal insufficiency animal model, we found that cortic

91 Current treatment options for adrenal insufficiency are limited to corticosteroid repl

92 Although primary and secondary adrenal insufficiency are rare, affecting less than 279

93 Although primary and secondary adrenal insufficiency are rare, glucocorticoid-induced a

94 in critically ill neonates and children with adrenal insufficiency are required to determine if these

95 Growth impairment and adrenal insufficiency are typical in SAMD9, whereas prog

96 Four of the nine patients had secondary adrenal insufficiency as determined by a normal aldoster

97 y be more promising in the prevention of the adrenal insufficiency associated with prolonged sepsis.

98 It is important to recognize patients with adrenal insufficiency, because this disorder may be fata

99 corticosteroid treatment benefits mice with adrenal insufficiency but harms mice without adrenal ins

100 erapy for a subgroup of septic patients with adrenal insufficiency but harms septic patients without

101 taneous candidiasis, hypoparathyroidism, and adrenal insufficiency, but patients also develop intesti

102 test performs well in patients with primary adrenal insufficiency, but the lower sensitivity in pati

103 f GC exposure to prevent perioperative acute adrenal insufficiency, but this practice is not well sup

104 t of patients met the diagnostic criteria of adrenal insufficiency by the low-dose test and 8% by the

105 Adrenal insufficiency can arise from a primary adrenal d

106 The exception is adrenal insufficiency caused by glucocorticosteroids whi

107 15%) patients in the hypofractionated group (adrenal insufficiency, colitis, diarrhoea, and hyponatre

108 Adrenal insufficiency, common in critically ill patients

109 sol was 10.0 +/- 4.8 microg/dL in those with adrenal insufficiency compared with 35.6 +/- 21.2 microg

110 Adrenal insufficiency continues to be a challenge for pa

111 Adrenal insufficiency contributes to morbidity in critic

112 5% CI, 28%-41%) had symptoms compatible with adrenal insufficiency defined by an AddiQoL-30 score 85

113 linked disorder that typically presents with adrenal insufficiency during infancy.

114 CTH or cortisol-secreting tumours, secondary adrenal insufficiency ensues because of the prior suppre

115 nd serve as hormone substitution in cases of adrenal insufficiency explain their effectiveness in sta

116 g., skin atrophy, osteoporosis, Addison-like adrenal insufficiency, fatty liver, and type 2 diabetes

117 nterferes with steroidogenesis and can cause adrenal insufficiency, fluconazole in standard doses is

118 ificantly greater than the AUC for secondary adrenal insufficiency for the high-dose cosyntropin test

119 s systemic inflammation and rescue mice with adrenal insufficiency from polymicrobial peritonitis.

120 affecting the risk of glucocorticoid induced adrenal insufficiency (GI-AI) include the duration of gl

121 ticoid (GC) therapy may result in GC-induced adrenal insufficiency (GIAI), but the prevalence and cli

122 wever, the mechanisms underlying ICS-related adrenal insufficiency have not been clarified.

123 The symptoms of long COVID and chronic adrenal insufficiency have striking similarities.

124 tery disease (HR, 2.2; 95% CI, 1.6-3.0), and adrenal insufficiency (HR, 6.2; 95% CI, 2.8-13.0) were a

125 HR, 2.5; 95% CI, 1.6-4.0), including primary adrenal insufficiency (HR, 9.9; 95% CI, 4.5-21.5) and ul

126 each with constitutional symptoms, colitis, adrenal insufficiency, hyperglycaemia, and hypokalaemia.

127 I, which classically manifests as a triad of adrenal insufficiency, hypoparathyroidism, and chronic m

128 of dehydroepiandrosterone supplementation in adrenal insufficiency, hypopituitarism, osteoporosis, sy

129 lts of newly revised diagnostic criteria for adrenal insufficiency (i.e., stress cortisol concentrati

130 milies with SRNS and facultative ichthyosis, adrenal insufficiency, immunodeficiency, and neurologica

131 ility that high-dose fluconazole might cause adrenal insufficiency in already compromised critically

132 The high prevalence of symptoms of adrenal insufficiency in association with lower basal co

133 hemical pathways associated with ICS-related adrenal insufficiency in asthmatic patients.

134 this study was to estimate the frequency of adrenal insufficiency in children with IBD that were at

135 The incidence of adrenal insufficiency in critically ill HIV-infected pat

136 There is a high incidence of adrenal insufficiency in critically ill HIV-infected pat

137 Adrenal insufficiency in critically ill patients is best

138 iscusses the current therapeutic approach to adrenal insufficiency in critically ill patients.

139 To help clarify the incidence of adrenal insufficiency in HIV-infected critically ill pat

140 rspective, as well as the clinical impact of adrenal insufficiency in HIV.

141 icoids, by adrenalectomy in animal models or adrenal insufficiency in humans, has shown that endogeno

142 We find no evidence of adrenal insufficiency in non-cirrhotic patients with cho

143 riteria for, and the prevalence of, relative adrenal insufficiency in patients with acute lung injury

144 Adrenal insufficiency in patients with classic 21-hydrox

145 nd defined clinical outcomes associated with adrenal insufficiency in preterm infants.

146 The frequency of secondary adrenal insufficiency in sepsis remains open to debate a

147 have a critical role in the manifestation of adrenal insufficiency in this model, through regulation

148 In addition, it examines the diagnosis of adrenal insufficiency in this population and provides an

149 The diagnosis of adrenal insufficiency in this population is challenging

150 itive than the high-dose test for diagnosing adrenal insufficiency in this population.

151 ay be helpful in identifying glucocorticoid (adrenal) insufficiency in patients with sepsis.

152 Adrenal insufficiency incidence was significantly higher

153 e and repeated patient education on managing adrenal insufficiency, including advice on how to increa

154 ls with adrenolectomized mice mimic clinical adrenal insufficiency, increase the susceptibility to se

155 Diagnosis of adrenal insufficiency involves early-morning measurement

156 Treatment of adrenal insufficiency involves supplemental glucocortico

157 sufficiency are rare, glucocorticoid-induced adrenal insufficiency is a common condition.

158 Adrenal insufficiency is a syndrome of cortisol deficien

159 Glucocorticoid-induced adrenal insufficiency is caused by administration of sup

160 Secondary adrenal insufficiency is caused by disorders affecting t

161 Adrenal insufficiency is caused by either primary adrena

162 Adrenal insufficiency is common in patients with septic

163 Adrenal insufficiency is common in septic patients with

164 million individuals, glucocorticoid-induced adrenal insufficiency is common.

165 Primary adrenal insufficiency is life threatening and can presen

166 t therapy, health-related quality of life in adrenal insufficiency is more severely impaired than pre

167 ry, the incidence of postural hypotension or adrenal insufficiency is similar among those receiving h

168 eroid if the patient is on vasopressor or if adrenal insufficiency is suspected; and e) monitor for l

169 toxemia (LPS injection), we demonstrate that adrenal insufficiency is triggered early in the disease.

170 Primary adrenal insufficiency is typically characterized by low

171 Diagnosis of adrenal insufficiency is usually delayed because the ini

172 te that the patients' growth retardation and adrenal insufficiency likely reflect the ubiquitous but

173 -related serious adverse events (pemphigoid, adrenal insufficiency, liver disorder).

174 Thus, in adrenal insufficiency, loss of glucocorticoid feedback b

175 Adrenal insufficiency may be common in adults and childr

176 In such patients, adrenal insufficiency must be treated with hydrocortison

177 te kidney injury, colitis, hypokalaemia, and adrenal insufficiency (n=1 each).

178 ults (n=1), prolonged QT interval (n=2), and adrenal insufficiency (n=1).

179 sisting of ulcerative/Crohn's colitis (n=6), adrenal insufficiency (n=5), hematological disorders (n=

180 lower sensitivity in patients with secondary adrenal insufficiency necessitates use of tests involvin

181 ocus and called ALADIN (alacrima, achalasia, adrenal insufficiency neurologic disorder).

182 We found that in the presence of fetal adrenal insufficiency, normal fetal lung development is

183 Reports of adrenal insufficiency occur but are rare and are confine

184 Although studies have indicated that adrenal insufficiency occurs after severe trauma and hem

185 Adrenal insufficiency occurs most in patients taking the

186 HPA axis activation and the role of relative adrenal insufficiency on the outcome of patients with ac

187 neumonitis (two [5%] and one [3%] patients), adrenal insufficiency (one [3%] and two [5%] patients),

188 For secondary adrenal insufficiency, only studies that stratified part

189 TH tests, patients were classified as having adrenal insufficiency or as normal.

190 Given the risk of adrenal insufficiency or crisis upon cessation of OCS, w

191 This improvement may be due to treatment of adrenal insufficiency or from direct cardiovascular effe

192 Postoperative adrenal insufficiency or steroid dependency developed in

193 wer than 5 persons with primary or secondary adrenal insufficiency or with fewer than 10 persons as n

194 ary dysfunction (OR, 6.5; 95% CI, 1.1-33.2), adrenal insufficiency (OR, 5.0; 95% CI, 1.04-20.2), depr

195 testing was the only variable predictive of adrenal insufficiency (p < .0001).

196 sociated with AIRE variants, such as primary adrenal insufficiency, pernicious anemia, type 1 diabete

197 Under conditions of prolonged stress or adrenal insufficiency, persistent ACTH-induced changes i

198 ation increased the likelihood of developing adrenal insufficiency (pooled relative risk 1.33; 95% co

199 understanding of the pathogenesis caused by adrenal insufficiency present significant barriers to ad

200 The prevalence of relative adrenal insufficiency (RAI) in critically ill cirrhosis

201 Relative adrenal insufficiency (RAI) was demonstrated in patients

202 larities to such in patients called relative adrenal insufficiency (RAI)-conferred a high risk for le

203 ients with pediatric septic develop relative adrenal insufficiency (RAI).

204 Thus, long-term management of patients with adrenal insufficiency remains a challenge, requiring an

205 -dependent sepsis and may indicate "relative adrenal insufficiency." Replacement glucocorticoid/miner

206 psis using genetic or surgical initiation of adrenal insufficiency resulted in increased mortality, b

207 Here we show that SF-1 +/- mice exhibit adrenal insufficiency resulting from profound defects in

208 he adrenal glands may be responsible for the adrenal insufficiency seen in patients with hemorrhagic

209 M4 and have shown that it is associated with adrenal insufficiency, short stature, and NK cell defici

210 Therefore, all patients with adrenal insufficiency should be instructed how to increa

211 Glucocorticoid-induced adrenal insufficiency should be suspected in patients wh

212 All patients with adrenal insufficiency should be treated with glucocortic

213 Secondary outcomes were adrenal insufficiency symptoms assessed by the Addison d

214 Here, we have described a primary adrenal insufficiency syndrome and steroid-resistant nep

215 rty-five (72%) patients met our criteria for adrenal insufficiency (the hepatoadrenal syndrome).

216 toms, but higher doses can increase risks of adrenal insufficiency through suppression of endogenous

217 ed corticosteroid insufficiency is caused by adrenal insufficiency together with tissue corticosteroi

218 ion, atrial fibrillation, hypophosphataemia, adrenal insufficiency, transaminitis, and infections.

219 In vasopressor-dependent patients without adrenal insufficiency, treatment with hydrocortisone did

220 In vasopressor-dependent patients with adrenal insufficiency, treatment with hydrocortisone was

221 Of the four patients with secondary adrenal insufficiency, two had a history of amenorrhea a

222 had immune-related SAEs, including two with adrenal insufficiency, two with pneumonitis, and one wit

223 ts with secondary and glucocorticoid-induced adrenal insufficiency typically have low or intermediate

224 Patients with adrenal insufficiency typically present with nonspecific

225 One patient with known adrenal insufficiency underwent conservative ablation an

226 Additionally, patients with primary adrenal insufficiency usually develop skin hyperpigmenta

227 The incidence of adrenal insufficiency was 21% (six of 28) with a cortiso

228 Adrenal insufficiency was an adverse event of special in

229 We hypothesized that absolute and relative adrenal insufficiency was common in children with system

230 Adrenal insufficiency was determined using a cosyntropin

231 The incidence of absolute and relative adrenal insufficiency was determined using several defin

232 ver, a unified approach to the assessment of adrenal insufficiency was not reached.

233 primary end point, whereas the prevalence of adrenal insufficiency was our secondary end point.

234 Absolute and relative adrenal insufficiency was prevalent in this cohort of ch

235 The area under the curve for primary adrenal insufficiency was significantly greater than the

236 with a complex progressive gait disorder and adrenal insufficiency, was referred for ophthalmic evalu

237 and 100% mortality in the three cases where adrenal insufficiency went unrecognized.

238 irus antigenemia, and other risk factors for adrenal insufficiency were determined.

239 he diagnostic criteria for etomidate-related adrenal insufficiency were fulfilled in 41 of 45 (91%) a

240 However, 61% of patients met the criteria of adrenal insufficiency when we used a baseline cortisol c

241 ction may underlie some forms of subclinical adrenal insufficiency, which become life threatening dur

242 The most serious potential adverse effect is adrenal insufficiency, which can be life threatening.

243 Primary adrenal insufficiency, which involves deficiency of all

244 d some aspects of OCS use in asthma, such as adrenal insufficiency, which underscores the need for fu

245 ath if untreated, can occur in patients with adrenal insufficiency who have inadequate glucocorticoid

246 metabolic pathways that are associated with adrenal insufficiency with ICS use.

247 ed patients should undergo an evaluation for adrenal insufficiency with the stress cortisol concentra

248 iod or early childhood with virilization and adrenal insufficiency, with or without salt loss; the mi