ライフサイエンスコーパス: adrenomedullin

1 ating the ability of the cells to respond to adrenomedullin.

2 ptor is involved in the autocrine actions of adrenomedullin.

3 m a receptor for additional peptides such as adrenomedullin.

4 t and mortality, using an assay of bioactive adrenomedullin.

5 these effects, "uncovering" an inhibition by adrenomedullin.

6 he balance between endothelin-1, apelin, and adrenomedullin.

7 r, type 1 and the antimicrobial peptide(AMP) adrenomedullin.

8 ed, one of which was found to be the peptide adrenomedullin.

9 ons, triggered by the lymphangiogenic factor adrenomedullin.

10 common mediators, such as uromodulin and pro-adrenomedullin.

11 crine factor whose formation is inhibited by adrenomedullin.

12 e collected at baseline, including bioactive-adrenomedullin.

13 eptide, calcitonin gene-related peptide, and adrenomedullin.

14 d by small hairpin RNA-mediated knockdown of adrenomedullin.

15 P1 forms a CGRP receptor, CLR/RAMP2 forms an adrenomedullin-1 (AM(1)) receptor, and CLR/RAMP3 forms a

16 duce calcitonin gene-related peptide-related adrenomedullin 2 (ADM2) and identify a previously unreco

17 s, CGRP, adrenomedullin (AM), and intermedin/adrenomedullin 2 (AM2), is well known to result in a Gal

18 the upregulation of five selected NE genes (adrenomedullin 2 [ADM2], histamine receptor H1 [HRH1], n

19 ted peptide (CGRP), adrenomedullin (AM), and adrenomedullin 2/intermedin (AM2/IMD) have overlapping a

20 Adrenomedullin 2/intermedin (AM2/IMD), adrenomedullin (A

21 n-1 (AM(1)) receptor, and CLR/RAMP3 forms an adrenomedullin-2 (AM(2)) receptor.

22 Intermedin/Adrenomedullin-2 (IMD), a newly described peptide with s

23 Previous studies show that adrenomedullin, a cerebrovasodilator, prevented sex depe

24 ammatory response, we focused our studies on adrenomedullin, a peptide produced in response to bacter

25 Adrenomedullin, a potent vasoactive peptide, is actively

26 Adrenomedullin, a recently identified potent vasodilator

27 Patients with a MR-pro-adrenomedullin above this cutoff level had an odds ratio

28 These data indicate that adrenomedullin acting via ADMR increases the aggressiven

29 eceptor expression had functional effects on adrenomedullin activity, with increasing secretin recept

30 JMJD1A regulates the expression of adrenomedullin (ADM) and growth and differentiation fact

31 hypoxia (pO(2) 20 torr, 8 h), we identified adrenomedullin (ADM) as a prominent hypoxia-inducible fa

32 PC cells identified Sonic-hedgehog (SHH) and Adrenomedullin (ADM) as two differentially-expressed gen

33 or a single nucleotide polymorphism near the adrenomedullin (ADM) gene (rs6484218), with the best-fit

34 Therefore, we evaluated whether modulating adrenomedullin (Adm) gene dosage within tumor cells affe

35 The angiogenic peptide adrenomedullin (ADM) has been implicated as a mediator o

36 erations in lipid metabolism are mediated by adrenomedullin (ADM) in normal and GDM pregnancies.

37 actor 2 (TFF2), trefoil factor 3 (TFF3), and adrenomedullin (ADM) in salivary samples of periodontiti

38 Adrenomedullin (ADM) is a circulating vasoactive peptide

39 The angiogenic factor adrenomedullin (ADM) is a hypoxia regulated gene.

40 Adrenomedullin (Adm) is a multifunctional peptide that e

41 Adrenomedullin (ADM) is a newly discovered endogenous va

42 Adrenomedullin (ADM) is elevated in heart failure (HF) a

43 The 52 amino acid peptide hormone adrenomedullin (ADM) plays a major role in the developme

44 Here, we report that adrenomedullin (ADM) significantly contributes to the ca

45 Production of adrenomedullin (ADM), a vasodilator peptide, increases i

46 nin, calcitonin gene-related peptide (CGRP), adrenomedullin (ADM), and amylin belong to a unique grou

47 monstrating that the dosage and signaling of adrenomedullin (Adm, gene; AM, protein)-a mitogenic pept

48 s endothelin-1, endothelin receptor A and B, adrenomedullin, adrenomedullin receptor, and vasopressin

49 ursor of atrial natriuretic peptide B and of adrenomedullin also increased approximately twofold.

50 The vasoactive hormone adrenomedullin (AM) and its binding protein (AMBP-1) are

51 Adrenomedullin (AM) and its receptor complexes, calciton

52 Two potent hypotensive peptides, adrenomedullin (AM) and proadrenomedullin N-terminal 20

53 expression of the pregnancy-related peptide adrenomedullin (AM) by fetal trophoblast cells is necess

54 Previous studies showed that adrenomedullin (AM) could be a promising agent for molec

55 milar to those of the recently characterized adrenomedullin (AM) gene KO despite the presence of elev

56 ecent study indicates that administration of adrenomedullin (AM) in combination with AM-binding prote

57 Adrenomedullin (AM) is a multifunctional peptide vasodil

58 Adrenomedullin (AM) is a multifunctional peptide vasodil

59 Adrenomedullin (AM) is a newly discovered hypotensive pe

60 Adrenomedullin (AM) is a peptide hormone with numerous e

61 Adrenomedullin (AM) is a potent lymphangiogenic factor t

62 Adrenomedullin (AM) is a potent vasodilator peptide in p

63 Adrenomedullin (AM) is an important regulatory peptide i

64 Adrenomedullin (AM) is peptide encoded, together with pr

65 ical chemokine receptor 3 (ACKR3) diminishes adrenomedullin (AM) ligand availability without changing

66 calcitonin gene-related peptide (CGRP), and adrenomedullin (AM) peptides.

67 We have previously demonstrated that adrenomedullin (AM) plays a critical role as an autocrin

68 Although adrenomedullin (AM) previously has been identified in hu

69 n gene-related peptide (CGRP) receptor or an adrenomedullin (AM) receptor.

70 Adrenomedullin (AM) signals through calcitonin receptor-

71 s calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) that have diverse functions in the c

72 ve shown that gene transfer of human and rat adrenomedullin (AM) up-regulates IL-13Ralpha2 in a human

73 cently shown that vascular responsiveness to adrenomedullin (AM), a newly discovered vasodilator pept

74 Adrenomedullin (AM), a potent hypotensive peptide, is pr

75 Plasma levels of adrenomedullin (AM), a potent vasorelaxant, are increase

76 Calcitonin gene-related peptide (CGRP), adrenomedullin (AM), and adrenomedullin 2/intermedin (AM

77 Adrenomedullin 2/intermedin (AM2/IMD), adrenomedullin (AM), and calcitonin gene-related peptide

78 g of one of the three peptide ligands, CGRP, adrenomedullin (AM), and intermedin/adrenomedullin 2 (AM

79 The anti-inflammatory peptide, adrenomedullin (AM), and its cognate receptor are expres

80 reast cancer cells, through the secretion of adrenomedullin (AM), induce downregulation of Zeb1 expre

81 tional receptor for the vasodilatory ligand, adrenomedullin (AM), is comprised of RAMP2 or RAMP3 and

82 escribed peptide with structural homology to adrenomedullin (AM), is present in brain and pituitary g

83 ng protein 2 (RAMP2) comprise a receptor for adrenomedullin (AM).

84 e have recently shown that administration of adrenomedullin (AM, a potent vasodilator peptide) and ad

85 Calcitonin gene-related peptide, adrenomedullin, amylin, atrial natriuretic peptide, and

86 nary studies indicate that administration of adrenomedullin and adrenomedullin binding protein-1 in c

87 the signaling of the two potent vasodilators adrenomedullin and calcitonin gene-related peptide, we t

88 Adrenomedullin and conditioned media from pancreatic cel

89 Our findings show tumor-promoting roles of adrenomedullin and identify CCL2 as an angiocrine factor

90 -induced increases in the vasoactive peptide adrenomedullin and infiltration of iNOS-positive leukocy

91 nduces the expression of the peptide hormone Adrenomedullin and its receptor component Ramp3, which a

92 087 critically ill patients, and AdrenOSS-1 (Adrenomedullin and Outcome in Severe Sepsis and Septic S

93 up-regulated the expression of vasodilators adrenomedullin and suppressed the expression of vasocons

94 ther potential targets, including amylin and adrenomedullin and their receptors, K(ATP) and transient

95 olymphangiogenic signaling pathways, such as adrenomedullin and VEGF (vascular endothelial growth fac

96 h higher urinary atrial natriuretic peptide, adrenomedullin, and cGMP excretions than with ACEI+D.

97 iuretic peptide, B-type natriuretic peptide, adrenomedullin, and homocysteine concentrations to arter

98 Plasma natriuretic peptide, adrenomedullin, and homocysteine levels are associated w

99 nase plasminogen activator surface receptor, adrenomedullin, and KIM-1 (kidney injury molecule 1) wer

100 ic toxicity of this molecular class, leptin, adrenomedullin, and the compounds associated with increa

101 ective effect of regulatory peptides such as adrenomedullin, and the influence of H. pylori on the ju

102 e proangiogenic HIF targets, including PlGF, adrenomedullin, angiogenin, and PAI-1.

103 Treatment of the cell cultures with an adrenomedullin antagonist inhibited basal levels of prol

104 Calcitonin-gene-related peptide (CGRP) and adrenomedullin are related peptides with distinct pharma

105 The current study investigated adrenomedullin as a potential autocrine regulator of pan

106 Using microarray analysis, we identified adrenomedullin as a potential mediator of diabetes in pa

107 ffect of B. burgdorferi on the expression of adrenomedullin as well as the ability of adrenomedullin

108 ypoxia-exposed cardiac fibroblasts expressed adrenomedullin at 4-fold increased levels, as determined

109 while macrophages in the endometrium express adrenomedullin at a low level, endometrial macrophages o

110 llaries, whereas Ace1 and AT1 inhibitors and adrenomedullin attenuated vasoobliteration in OIR, indic

111 ullin (AM, a potent vasodilator peptide) and adrenomedullin binding protein-1 (AMBP-1) prevented the

112 te that administration of adrenomedullin and adrenomedullin binding protein-1 in combination (AM/AMBP

113 established that keratinocytes do not store adrenomedullin but secrete it constitutively.

114 dometrial induction of the angiogenic factor adrenomedullin by tamoxifen is part of the mechanism by

115 Since CGRP and adrenomedullin can both signal through CRLR, which has b

116 d to congestion, such as biologically active adrenomedullin, cancer antigen 125, and N-terminal pro-B

117 ociated with risk of HF, whereas higher ADM (adrenomedullin), CHI3L1 (chitinase-3-like protein 1), CT

118 2 potent vasodilator factors apelin and ADM (adrenomedullin) compared with Bmp9(+/+) littermates.

119 in, medium chain acyl-CoA dehydrogenase, and adrenomedullin correlate equally well with the degree of

120 r a set of biomarkers (procalcitonin, MR-pro-adrenomedullin, CT-pro-endothelin-1, CT-pro-arginine vas

121 levels of C-reactive protein, procalcitonin, adrenomedullin (either bioavailable adrenomedullin or mi

122 The association of natriuretic peptides, adrenomedullin, endothelin, and galectin-3 with new-onse

123 d a significant decrease in the secretion of adrenomedullin, endothelin-1, and CD105; molecules that

124 Because adrenomedullin exhibits low metabolic stability, enhance

125 Mean plasma levels of adrenomedullin (femtomoles per liter) were higher in pat

126 ify CCL2 as an angiocrine factor controlling adrenomedullin formation by tumor cells.

127 Furthermore, CCL2 inhibited adrenomedullin formation in tumor cells through its rece

128 free at least one target, the proangiogenic adrenomedullin, from repression, enhancing vascular grow

129 These data demonstrate that the adrenomedullin gene is developmentally regulated in vent

130 These results support a physiologic role for adrenomedullin gene products in the central regulation o

131 g the technique of differential display, the adrenomedullin gene was observed to be differentially ex

132 N-terminal peptide (PAMP), by the Adm gene (adrenomedullin gene).

133 ivo and in vivo angiogenesis models that the adrenomedullin gene-related peptide, proadrenomedullin N

134 rminal 20 peptide (PAMP), are encoded by the adrenomedullin gene.

135 and downstream targets of HIF (endothelin-1, adrenomedullin, haem oxygenase 1, and vascular endotheli

136 We report that tumor cell-derived adrenomedullin has a pro-angiogenic as well as a direct

137 Adrenomedullin has vascular properties and elevated plas

138 and N-terminal probrain natriuretic peptide: adrenomedullin (hazard ratio per log increase 2.53), ago

139 r-15 (HR, 1.67; 95% CI, 1.32-2.12; P<0.001), adrenomedullin (HR, 1.58; 95% CI, 1.23-2.04; P<0.001), u

140 tio [HR], 1.68 per SD increase), proADM (pro-adrenomedullin; HR, 1.60), GDF-15 (growth differentiatio

141 ptional up-regulation of CRLR and its ligand adrenomedullin in endothelial cells could lead to a pote

142 Conversely, overexpression of adrenomedullin in mice with pancreatic cancer led to glu

143 We measured plasma levels of adrenomedullin in patients with pancreatic cancer, patie

144 ri significantly increased the expression of adrenomedullin in RAW264.7 macrophages through MyD88-, p

145 these tissues; however, the concentration of adrenomedullin in saliva was insufficient to suggest a s

146 The concentration of adrenomedullin in the synovial fluid of untreated Lyme a

147 dings suggest a paracrine/autocrine role for adrenomedullin in these tissues; however, the concentrat

148 Elevated bioactive adrenomedullin independently predicted 1) the need for o

149 g of ADMR in pancreatic cancer cells blocked adrenomedullin-induced growth and invasion, indicating t

150 ived CC chemokine ligand 2 (CCL2) suppresses adrenomedullin-induced tumor cell proliferation.

151 The AC stimulatory agonist adrenomedullin inhibited collagen synthesis in CF that o

152 Pancreatic cancer cell lines also secreted adrenomedullin into the culture medium as determined by

153 Adrenomedullin is a 52 amino acid peptide that shows a r

154 MR-pro-adrenomedullin is a good predictor of mortality (c-stati

155 Adrenomedullin is a multifunctional peptide produced by

156 We have shown that adrenomedullin is a novel growth factor for endothelial

157 Adrenomedullin is a recently discovered hypotensive pept

158 Early measurement of bioactive adrenomedullin is a strong predictor of the need of orga

159 Adrenomedullin is able to act through at least two diffe

160 Single-cell RNA sequencing defines that adrenomedullin is expressed by activated fibroblasts and

161 is study was designed to investigate whether adrenomedullin is present in human saliva and in salivar

162 Adrenomedullin is up-regulated in patients with pancreat

163 Furthermore, increasing adrenomedullin levels by gene transfer to Panc-1 cells i

164 has vascular properties and elevated plasma adrenomedullin levels were detected in sepsis.

165 at can be reversed upon genetic depletion of adrenomedullin ligand.

166 This raises the possibility that adrenomedullin may serve a different functions in oral m

167 In elective cardiac surgery, MR-pro-adrenomedullin measured between 6 and 18 hours after adm

168 ch as vascular endothelial growth factor and adrenomedullin mediate a comparable effect at nanomolar

169 ell dysfunction through oxidative stress and adrenomedullin-mediated insulin secretion inhibition.

170 hat express antisense RCP RNA, and CGRP- and adrenomedullin-mediated signal transduction were greatly

171 Adrenomedullin-mediated signaling was disrupted when P32

172 Levels of adrenomedullin messenger RNA and protein were increased

173 issues (controls) to determine expression of adrenomedullin messenger RNA and protein, respectively.

174 Treating mice with adrenomedullin mimicked the effect of obesity and induce

175 ess the prognostic impact of midregional pro-adrenomedullin (MR-proADM) after an acute myocardial inf

176 and the prognostic value of mid-regional pro-adrenomedullin (MR-proADM) in patients with AHF.

177 l provasopressin (copeptin), midregional pro-adrenomedullin (MR-proADM), and midregional pro-atrial n

178 iuretic peptide (MR-proANP), midregional pro-adrenomedullin (MR-proADM), C-terminal pro-endothelin-1

179 Adrenomedullin mRNA levels were significantly (P < 0.05)

180 in a significant, time-dependent increase in adrenomedullin mRNA levels.

181 reaction analysis revealed that the level of adrenomedullin mRNA was significantly higher in adult ve

182 brain, heart, kidney, liver, and lung, with adrenomedullin, MT-1, and VEGF being prominently induced

183 Median plasma bioactive adrenomedullin (n = 2,003) was 66.6 pg/mL (34.6-136.4 pg

184 e in production of the pulmonary vasodilator adrenomedullin of almost 70% (P </= 0.05).

185 We studied the effects of adrenomedullin on insulin secretion by beta cell lines a

186 MED (62.6 %; 48 % of TE is PIE), followed by adrenomedullin or ADM.

187 citonin, adrenomedullin (either bioavailable adrenomedullin or midregional fragment of proadrenomedul

188 have revealed the utility of circulating AM (adrenomedullin) or MR-proAM (mid-regional proAM 45-92) a

189 f women receiving tamoxifen strongly express adrenomedullin (P=0.008).

190 e expression of TGF-beta target genes (e.g., adrenomedullin, pentraxin 3, KN motif and ankyrin repeat

191 pithelium may contribute the majority of the adrenomedullin peptide found in saliva.

192 l. demonstrate that loss of signaling by the adrenomedullin peptide results in embryonic edema and de

193 ing attention to procalcitonin (PCT) and pro-adrenomedullin (proADM).

194 t there are differences in the regulation of adrenomedullin production between oral and skin keratino

195 ibes the effects of a range of substances on adrenomedullin production from cultures of oral and skin

196 peptides thrombin and endothelin-1 increase adrenomedullin production, particularly from skin kerati

197 s binding sites were identified in the mouse adrenomedullin promoter at -1095 and -770 nucleotides fr

198 ily mediated by HIF-1 consensus sites in the adrenomedullin promoter.

199 scriptase-PCR as follows: VEGF, EPO, GLUT-1, adrenomedullin, propyl 4-hydroxylase alpha, MT-1, MKP-1,

200 Mast cell-specific mediators and adrenomedullin (proteolytic precursor of PAMP-12, an MRG

201 ct through at least two different receptors, adrenomedullin receptor (ADMR) and calcitonin receptor-l

202 n 5 (cdh5; VE-cadherin), aquaporin 8 (aqp8), adrenomedullin receptor (admr), complement receptor C1qR

203 Loss of the endothelial adrenomedullin receptor CALCRL or of the G-protein Gs re

204 on, we now propose that a functional CGRP or adrenomedullin receptor consists of at least three prote

205 Endothelial loss or blockade of the adrenomedullin receptor improved obesity-induced insulin

206 Adrenomedullin receptor mRNA was constitutively expresse

207 endothelin receptor A and B, adrenomedullin, adrenomedullin receptor, and vasopressin receptor 1a.

208 can function as either a CGRP receptor or an adrenomedullin receptor, depending on which members of a

209 In obese mice lacking the endothelial adrenomedullin receptor, insulin-induced endothelial nit

210 se with the pharmacological properties of an adrenomedullin receptor.

211 gene-related peptide (CGRP) receptor and an adrenomedullin receptor.

212 receptor-like receptor to yield a functional adrenomedullin receptor.

213 For example, adrenomedullin receptors are comprised of RAMP2 or RAMP3

214 Specific adrenomedullin receptors were found in cell lines from t

215 rted receptors are core-glycosylated and are adrenomedullin receptors.

216 d interferon-gamma are potent suppressors of adrenomedullin secretion from both cell types, as are fo

217 lipopolysaccharide, significantly stimulate adrenomedullin secretion from oral but not skin keratino

218 ome recognized as integral components of the adrenomedullin signaling system.

219 y VEGF-C or noncanonically transactivated by adrenomedullin signaling, impairing downstream processes

220 transfer to Panc-1 cells increased, whereas adrenomedullin small hairpin RNA silencing in MPanc96 ce

221 Adrenomedullin suppression in T(H) 2-related inflammatio

222 oteins, in addition to tryptase, E-selectin, adrenomedullin, T-cell immunoglobulin, and mucin domain

223 id glands contained higher concentrations of adrenomedullin than did the circulation, but lower conce

224 U patients, the relation between circulating adrenomedullin, the need for organ support and mortality

225 Furthermore, the addition of exogenous adrenomedullin to B. burgdorferi-stimulated RAW264.7 mac

226 of adrenomedullin as well as the ability of adrenomedullin to dampen host inflammatory responses to

227 egulated in ventricular cardiomyocytes, that adrenomedullin transcription can be induced by hypoxia,

228 Exogenous adrenomedullin treatment of Panc-1, BxPC3, and MPanc96 c

229 pression of other angiogenic factors such as adrenomedullin, vascular endothelial growth factor, basi

230 Elevated bioactive adrenomedullin was also associated with a prolonged leng

231 In men, adrenomedullin was associated with mean arterial pressur

232 es revealed that the 5'-flanking sequence of adrenomedullin was capable of mediating a hypoxia-induci

233 Adrenomedullin was localized in the neoplastic epitheliu

234 Adrenomedullin was up-regulated in pancreatic cancer cel

235 was related to systolic blood pressure; ADM (adrenomedullin) was related to systolic blood pressure a

236 Levels of adrenomedullin were higher in patients with pancreatic c

237 eas decreases in PAP in response to CGRP and adrenomedullin were not changed and decreases in PAP in

238 plasminogen activator surface receptor, and adrenomedullin were novel early markers of CVD.

239 at saliva may contain high concentrations of adrenomedullin, which has antimicrobial activity in vitr

240 t B. burgdorferi increases the production of adrenomedullin, which in turn negatively regulates the B

241 relationship and 7 were druggable, including adrenomedullin, which represents a particularly promisin

242 We show that adrenomedullin, whose plasma levels are increased in obe

243 t resulted in a sustained increase in plasma adrenomedullin, with higher urinary atrial natriuretic p