ライフサイエンスコーパス: adrenoreceptor

1 th adjacent structural domains in the beta 2 adrenoreceptor.

2 azosin activated EphA2 independent of alpha1-adrenoreceptor.

3 puts to these neurons via presynaptic alpha2-adrenoreceptors.

4 scending inputs and the activation of beta 1-adrenoreceptors.

5 ar glutamatergic neurons that express alpha1-adrenoreceptors.

6 signal transduction pathway linked to alpha1-adrenoreceptors.

7 enough to activate low-threshold inhibitory adrenoreceptors.

8 cus coeruleus, acting through alpha and beta adrenoreceptors.

9 phrine to investigate signal transduction of adrenoreceptors.

10 ted with an up-regulation in alpha1-vascular adrenoreceptors.

11 ion, desensitization, and uncoupling of beta-adrenoreceptors.

12 ding vasodilatation through activating alpha-adrenoreceptors.

13 arkers of polymorphisms of candidate alpha2A adrenoreceptor, 5-HT transporter, and GNbeta3 genes and

14 g and receptor conformation of the alpha(1A)-adrenoreceptor, a GPCR that stimulates smooth muscle con

15 tory period of up to 48 h in culture, alpha1-adrenoreceptor activation by phenylephrine or noradrenal

16 w that chemogenetic Gq activation and alpha1 adrenoreceptor activation in mouse BLA parvalbumin (PV)

17 mediate the natriuretic response to alpha(2)-adrenoreceptor activation in vivo.

18 the prior history of hypoxia and that alpha2 adrenoreceptor activation plays a role in its underlying

19 were mimicked by either alpha 1- or alpha 2-adrenoreceptor activation, reversibly decreasing motor b

20 licular cells in response to NE-induced beta-adrenoreceptor activation.

21 ed during enforced HSC mobilization or beta3 adrenoreceptor activation.

22 ger is regulated by isoproterenol via a beta-adrenoreceptor/adenylate-cyclase/cAMPdependent signaling

23 d to activation of muscle postsynaptic beta2-adrenoreceptor (ADRB2), cAMP production, and import of t

24 rotein-coupled receptors (GPCRs): the beta-2 adrenoreceptor (ADRB2), the adenosine A(2A) receptor (AA

25 bone microarchitecture and the expression of adrenoreceptors, aggrecans, matrix metalloproteinases (M

26 r agonist midodrine (5 to 10 mg), the alpha2-adrenoreceptor agonist clonidine (0.1 mg), and I.V. sali

27 CSH enhanced the alpha2-adrenoreceptor agonist clonidine-mediated inhibition (3

28 human monocytes, epinephrine and the beta(2) adrenoreceptor agonist fenoterol potently inhibited LPS-

29 A new beta-3 adrenoreceptor agonist has demonstrated significant impr

30 e studied the effects of placebo, the alpha1-adrenoreceptor agonist midodrine (5 to 10 mg), the alpha

31 e opposite was the case either for an alpha2-adrenoreceptor agonist or for inhibition of catecholamin

32 The alpha-adrenoreceptor agonist phenylephrine increased arterial

33 NHE1 phosphorylation induced by the alpha(1)-adrenoreceptor agonist phenylephrine, without affecting

34 - 5%, n = 4; p < 0.05) but attenuated alpha1-adrenoreceptor agonist phenylephrine-mediated inhibition

35 Additionally, isoproterenol, a beta adrenoreceptor agonist suppressed LPS-induced TNF-alpha

36 Ractopamine (RAC) is a beta-adrenoreceptor agonist that enhances growth but increase

37 Dexmedetomidine is a selective alpha2 adrenoreceptor agonist that has been described as a usef

38 e (PE, 0.025 to 0.8 mug kg min) and an alpha-adrenoreceptor agonist, BHT-933 (1.0 to 10 mug kg min) d

39 Infusions of the beta-adrenoreceptor agonist, clenbuterol, into the BLA immedi

40 When infused into the CA1, the beta-adrenoreceptor agonist, isoproterenol, the D1/D5 dopamin

41 d during intra-arterial infusion of an alpha-adrenoreceptor agonist, phenylephrine (PE, 0.025 to 0.8

42 729 to act at FFA2 receptors to inhibit beta-adrenoreceptor agonist-promoted lipolysis in primary mou

43 tor antagonists (LAMA) and long-acting beta2-adrenoreceptor agonists (LABA), are the mainstay of phar

44 Microinfusion of alpha2 adrenoreceptor agonists and antagonists into amygdala ha

45 report showing that microinfusion of alpha 2 adrenoreceptor agonists and antagonists into the vicinit

46 be stimulated 19-61% above baseline by beta-adrenoreceptor agonists and cGI-phosphodiesterase inhibi

47 These cells were incubated with beta-adrenoreceptor agonists and/or antagonists and assayed f

48 nt and selective sulfonamide derived beta(2)-adrenoreceptor agonists are described that exhibit poten

49 protocols: (1) wide dose ranges of the alpha-adrenoreceptor agonists phenylephrine (PE, alpha(1) sele

50 Both alpha(1)- and alpha(2)-adrenoreceptor agonists produce comparable vasoconstrict

51 beta2 -Adrenoreceptor agonists that act via cAMP can reduce ute

52 enoreceptor antagonism and mimicked by beta2-adrenoreceptor agonists.

53 5-HT(1A) receptor and alpha(1)-adrenoreceptor (alpha(1)-AR) binding sites recognized by

54 sue transglutaminase (TGII)-mediated alpha1B-adrenoreceptor (alpha(1B)AR) signaling.

55 sults confirmed the distribution of alpha(2) adrenoreceptor (alpha(2) -AR) in RMECs.

56 al CGRP expression via activation of alpha 2-adrenoreceptors (alpha 2-AR) on DRG neurons.

57 Stimulation of alpha1-adrenoreceptors (alpha1-AR) acutely alters ion channel b

58 ve randomized controlled trial of the alpha1-adrenoreceptor (alpha1AR) antagonist prazosin for combat

59 is attenuated during advanced age via alpha-adrenoreceptor (alphaAR) activation, but it is unknown w

60 on and is attenuated during ageing via alpha-adrenoreceptor (alphaAR) stimulation, but it is unknown

61 ng results from cryocooled crystals of beta2-adrenoreceptor and an RNA polymerase II complex indicate

62 Galpha(sS)-N280 interacted with the beta(2)-adrenoreceptor and exhibited high-affinity XTPase activi

63 ta receptors) mediated chemotaxis; the beta2-adrenoreceptor and the M3-muscarinic receptor, which cou

64 in two other serpentine receptors, the beta2-adrenoreceptor and the parathyroid hormone receptor; occ

65 s controls the conformation of the alpha(1A)-adrenoreceptor and underlies the mechanism of ligand mod

66 eased and inverted complement of beta1/beta2-adrenoreceptors and absence of RyR2, which may explain t

67 n pattern, show partial overlap with alpha 2 adrenoreceptors and are heavily represented in sensory p

68 M prazosin) or alpha2- (0.1 microM RX821002) adrenoreceptors and fully restored with both antagonists

69 blocked by pharmacologic antagonists of beta-adrenoreceptors and the myelopoietic growth factor GM-CS

70 This effect was blocked by beta2-adrenoreceptor antagonism and mimicked by beta2-adrenore

71 inished by prior hypoxic episodes and alpha2-adrenoreceptor antagonism.

72 Clinically used as an alpha1-adrenoreceptor antagonist (Cardura(R)) for treating hype

73 lasma ACTH after microinjecting the alpha(1)-adrenoreceptor antagonist benoxathian into the BSTL.

74 i.c.v. infusion of the alpha1-adrenoreceptor antagonist benoxathian, at up to 5.3 micr

75 The alpha1-adrenoreceptor antagonist doxazosin induces apoptosis in

76 he ability of the quinazoline-based alpha(1)-adrenoreceptor antagonist doxazosin to suppress prostate

77 Administration of the beta-adrenoreceptor antagonist esmolol (1 mg kg(-1)) also att

78 The alpha-adrenoreceptor antagonist phentolamine abolished NE inhi

79 This increase was inhibited by the alpha(1)-adrenoreceptor antagonist prazosin (1 microM) and blocke

80 k randomized controlled trial of the alpha-1 adrenoreceptor antagonist prazosin for combat trauma nig

81 The alpha2-adrenoreceptor antagonist yohimbine abolished CSH-induce

82 When infused into the BLA, the beta-adrenoreceptor antagonist, timolol, the D1/D5 dopamine r

83 evation was prevented by propranolol, a beta-adrenoreceptor antagonist.

84 ; these effects were abolished by an alpha2A-adrenoreceptor antagonist.

85 Moreover, these adrenoreceptor antagonists alone were sufficient to mark

86 alpha1 and alpha2 adrenoreceptor antagonists included in the medium of cor

87 Saline vehicle, alpha2- and beta-adrenoreceptor antagonists or agonists were injected loc

88 lin or dibutyryl-cAMP) and abrogated by beta-adrenoreceptor antagonists or the PKA inhibitor rp-cAMP,

89 lol and carvedilol are third-generation beta-adrenoreceptor antagonists, which unlike classic beta-bl

90 yperalgesia (PPH), can be blocked with alpha-adrenoreceptor antagonists.

91 to perivascular nerve stimulation (PNS) and adrenoreceptor (AR) activation during blood flow control

92 a single systemic administration of the beta-adrenoreceptor (AR) blocker propranolol before femur ost

93 rt is controlled by stimulation of the beta1-adrenoreceptor (AR) signaling cascade, which leads to ac

94 through the selective activation of alpha-2 adrenoreceptors (AR).

95 Since alpha(2c)-adrenoreceptors are expressed primarily in the brain, we

96 HEK 293 cells, while co-expressed alpha(2C)-adrenoreceptors are found mainly in an intracellular com

97 pharmacological tests indicate that alpha 1-adrenoreceptors are involved in the permissive role of N

98 alpha-Adrenoreceptors are present in the ventricular (VZ) and

99 Antagonists of beta-adrenoreceptors are safe and well tolerated in patients

100 Our data indicate that RARs, like beta2-adrenoreceptors, are sensitive to inverse agonists and t

101 Both beta(1)- and beta(2)-adrenoreceptor (ARs) subtypes induce cAMP accumulation,

102 i-LC dendritic zone, as determined by alpha2-adrenoreceptors (ARs) and norepinephrine transporter bin

103 Acute pharmacological blockade of alpha1 adrenoreceptors (ARs) attenuates the locomotor response

104 Activation of vascular adrenoreceptors (ARs) governs the magnitude and distribu

105 assessed by immunoblotting using the beta(2)-adrenoreceptor as a standard.

106 Furthermore, inhibition of alpha2A-adrenoreceptor attenuated degenerative remodelling in th

107 enhances CFC and that antagonism of the beta-adrenoreceptors attenuates this effect.

108 In PC12 cells the expressed alpha(2C)-adrenoreceptors become concentrated in neurite outgrowth

109 MNR increased the gene expression of adrenoreceptor beta 2 (ADRB2) and the phosphorylation of

110 observed in both sexes, including increased adrenoreceptor beta 2 (ADRB2) expression and protein abu

111 enes such as uncoupling protein 1 (Ucp1) and adrenoreceptor beta 3 (Adrb3).

112 In contrast to beta(1)-adrenoreceptor (beta(1)-AR) signaling, beta(2)-AR stimul

113 get conformation-specific endogenous beta(2)-adrenoreceptor (beta(2)-AR) in neurosecretory cells, unv

114 gically relevant system in which the beta(2)-adrenoreceptor (beta(2)AR) couples to G(s), and Sf9 inse

115 icient PDZ-directed recycling of the beta(2)-adrenoreceptor (beta(2)AR) from early endosomes.

116 The G protein-coupled beta(2)-adrenoreceptor (beta(2)AR) signals through the heterotri

117 Obesity is associated with blunted beta-adrenoreceptor (beta-AR)-mediated lipolysis and lipid ox

118 The three known subtypes of beta-adrenoreceptors (beta(1)-AR, beta(2)-AR, and beta(3)-AR)

119 Desensitization of the beta-adrenoreceptors (beta-AR) may contribute to a post-exerc

120 Sympathetic activation of beta-adrenoreceptors (beta-AR) represents a hallmark in the d

121 that the activation of the Gs-coupled beta1-adrenoreceptor (beta1-AR) by the catecholamines isoprena

122 rolled well in most patients by inhaled beta-adrenoreceptor (beta2 AR) agonists and steroids.

123 othelial HMEC-1 cells by counteracting beta2-adrenoreceptor (beta2ADR) activity using pharmacological

124 e association between montelukast use, beta2-adrenoreceptor (beta2AR) agonist use, and later Parkinso

125 bined use of glucocorticosteroids and beta-2-adrenoreceptor (beta2AR) agonists in the treatment of ch

126 bronchodilators in asthma therapy are beta2-adrenoreceptor (beta2AR) agonists, but their chronic use

127 The beta2-adrenoreceptor (beta2AR) couples to the G-protein Gs to

128 The beta2 adrenoreceptor (beta2AR) is a prototypical G protein-cou

129 ene expression, we discovered that the beta2-adrenoreceptor (beta2AR) is a regulator of the alpha-syn

130 mRNA and increases the density of alpha(1B)-adrenoreceptor binding in the hypothalamus.

131 H(4) + 10 mM ascorbate, and (4) 5 mM BH(4) + adrenoreceptor blockade (5 mM yohimbine + 1 mM propranol

132 chronic hypoxia (21-28 days; ~4300 m), local adrenoreceptor blockade (combined alpha- and beta-adrene

133 cholamine levels, and the effect of alpha(1)-adrenoreceptor blockade (phentolamine) on supine SBP.

134 DeltaCVC(base); P < 0.001), however, adding adrenoreceptor blockade abolished VC in aged skin indica

135 Local adrenoreceptor blockade at HA restored FBF during exerci

136 Use of beta-adrenoreceptor blockade in the treatment of heart failur

137 Local adrenoreceptor blockade increased FBF and FVC at rest an

138 This study tested the hypothesis that beta1-adrenoreceptor blockade modulates the angiotensin II (An

139 foot was used to monitor the degree of alpha-adrenoreceptor blockade produced by phentolamine.

140 ns and during combined local alpha- and beta-adrenoreceptor blockade via intra-arterial infusions of

141 ified sites of vascular dysfunction in OZRs (adrenoreceptor blockade with phentolamine, antioxidant t

142 These effects were abolished by either beta-adrenoreceptor blockade with propranolol or adrenalectom

143 duals ingested either a placebo or an alpha1-adrenoreceptor blocker (prazosin; 0.05 mg kg(-1)).

144 n cyan fluorescent protein-labeled alpha(2A)-adrenoreceptors (C-alpha2ARs) and G proteins in cells us

145 Inhibition of the beta-adrenoreceptor-cAMP signaling pathway prevented the indu

146 bodies that activate the beta(1)-AR (beta(1)-adrenoreceptor) can induce heart failure in animal model

147 We find that beta2 adrenoreceptors constitutively associate with each other

148 lasts, a significant proportion of alpha(2C)-adrenoreceptor detected by immunocytochemistry co-locali

149 Additionally, heterogeneity in cerebral adrenoreceptor distribution highlights region-specific a

150 esting diameter but this inhibition of alpha-adrenoreceptors enabled ROV to spread along the anastomo

151 alpha2a (alpha(2A))- and alpha2c (alpha(2C))-adrenoreceptors expressed in the same cell line.

152 ed by perivascular SNS fibers acting on beta-adrenoreceptors expressed on nonhematopoietic cells and

153 Increased alpha2A-adrenoreceptor expression was observed in condylar carti

154 ith liraglutide demonstrated decreased beta1-adrenoreceptor expression.

155 ta-arrestin-1 (ARRB1), activated via beta(2)-adrenoreceptors, facilitates AKT-mediated activation of

156 ctivity in cell membranes expressing alpha2A adrenoreceptor-Galphao1 wild-type (wt) or C351I mutant f

157 ce with a targeted disruption of the beta(3)-adrenoreceptor gene (beta(3)-AR KO) were treated with ve

158 thesis that constitutive activation of alpha-adrenoreceptors governs blood flow distribution within i

159 A dynamic orthostatic hypovolemia and alpha1-adrenoreceptor hypersensitivity have been demonstrated i

160 memory retrieval, while blockade of HPC beta-adrenoreceptors impaired encoding.

161 A crystal structure of the beta2-adrenoreceptor in complex with a covalent noradrenaline

162 at the resulting mutants bind to the beta(2)-adrenoreceptor in vitro in a phosphorylation-independent

163 This study tested whether activation of adrenoreceptors in chondrocytes has roles in degenerativ

164 cle of OM through subtle activation of alpha-adrenoreceptors in microvascular resistance networks.

165 ave investigated the possible role of alpha1-adrenoreceptors in regulating the germination of progeni

166 dicate that constitutive activation of alpha-adrenoreceptors in skeletal muscle can restrict the spre

167 n greater density of alpha(1)- than alpha(2)-adrenoreceptors in the mouse nucleus.

168 nist propranolol, suggesting a role for beta-adrenoreceptors in this response.

169 for AGS in GEPR-9s and that NMDA and alpha1 adrenoreceptors in this site may play important roles in

170 red the intracellular targeting of alpha(2C)-adrenoreceptors in two neuroendocrine cell lines with th

171 nt cells with moderate potency via an alpha1-adrenoreceptor-independent mechanism.

172 enylephrine) or alpha2- (1 microM UK 14,304) adrenoreceptors inhibited conduction partially and their

173 Thus, the activation of alpha1- and alpha2-adrenoreceptors inhibits conducted vasodilatation throug

174 Conversely, activation of alpha2A-adrenoreceptor intensified aforementioned degenerative c

175 restingly, the persistent activation of beta-adrenoreceptors is likely one of the upstream repressors

176 ression of a C-terminal fragment of the beta-adrenoreceptor kinase, which sequesters free betagamma,

177 istent with the D3 receptor adopting a beta1-adrenoreceptor-like quaternary arrangement.

178 Thus, blockade of beta-adrenoreceptors may provide a new avenue to inhibit VEGF

179 indicate that 1 nM prorenin enhanced alpha1-adrenoreceptor-mediated contraction, associated with an

180 e present study was to test whether alpha(2)-adrenoreceptor-mediated vasoconstriction was more sensit

181 The results indicated that alpha-adrenoreceptor modulation of the mGluR-mediated inhibiti

182 stradiol treatment in vivo induces alpha(1b)-adrenoreceptor mRNA and increases the density of alpha(1

183 ublished crystal structures of dimeric beta1-adrenoreceptor, mu-opioid, and CXCR4 receptors.

184 the role of the complete ECS of the alpha1B-adrenoreceptor on norepinephrine (NE) potency, affinity,

185 ses chronic pain through inhibitory alpha(2)-adrenoreceptors on afferent nociceptors and stimulatory

186 conducted vasodilatation by activating alpha-adrenoreceptors on feed arteries through noradrenaline r

187 germinal cells, and the expression of alpha1-adrenoreceptors on their surface could act to determine

188 Blockade of alpha2-adrenoreceptors or catecholamine-generating enzymes grea

189 ngiogenesis, vascular endothelial growth and adrenoreceptor pathways were enriched in the viviparous

190 Activated beta(2)-adrenoreceptors promote Gs-protein-dependent activation

191 The beta2-adrenoreceptors regulate VEGF expression in ChECs and RP

192 The results suggest that alpha-adrenoreceptor regulation of the mGluR-mediated inhibiti

193 However, after 14 d of cocaine, alpha-adrenoreceptor regulation of the mGluR-mediated inhibiti

194 alpha(2A)-Adrenoreceptors reside primarily in the plasma membrane

195 tion, pharmacological blockade of NRe alpha1-adrenoreceptors selectively impaired memory retrieval, w

196 d TPC2 comprise an important element in beta-adrenoreceptor signal transduction in cardiac myocytes.

197 A component of beta-adrenoreceptor signaling in the heart involves NAADP and

198 The effect of beta-adrenoreceptor signaling on expression of vascular endot

199 tor rp-cAMP, indicating transduction via the adrenoreceptor signaling pathway.

200 hlight a so far underrated role of alpha(2A)-adrenoreceptor signalling, encoded at ADRA2A, as a possi

201 In Mz-ChA-1 cells, alpha(2)-adrenoreceptor stimulation causes up-regulation of cAMP,

202 play a critical role in the response to beta-adrenoreceptor stimulation occurring during acute exerci

203 r CD38, which contributes to effects of beta-adrenoreceptor stimulation to increase both Ca(2+) trans

204 st stimuli, although constriction to alpha1 -adrenoreceptor stimulation was elevated.

205 ytes from WT mice, but these effects of beta-adrenoreceptor stimulation were reduced in myocytes from

206 endency for arrhythmias following acute beta-adrenoreceptor stimulation.

207 Surprisingly, antagonism or agonism of adrenoreceptor subtypes in the mPFC had no effect on mem

208 of the cerebrovasculature, and differential adrenoreceptor subtypes, density, distribution and sensi

209 alpha-Adrenoreceptor supersensitivity in many tissues has been

210 ly mediated by an axon reflex and that alpha-adrenoreceptor supersensitivity occurs in the presynapti

211 stress hormone adrenaline stimulates beta(2)-adrenoreceptors that are expressed throughout the body,

212 ein alpha-subunit (Gsalpha) couples the beta-adrenoreceptor to adenylyl cyclase and the intracellular

213 d AtT20 cells efficiently targeted alpha(2C)-adrenoreceptors to the plasma membrane.

214 f [(13)C(e)H(3)]methionine-labeled alpha(1A)-adrenoreceptor variants, each exhibiting differing signa

215 , Leu-311, Asn-312) in TMD VII of the beta 2 adrenoreceptors were mutated to the amino acids found in

216 H in normal human subjects by blocking alpha-adrenoreceptors with intravenous phentolamine.

217 With no effect in YM, blockade of alpha-adrenoreceptors with phentolamine (1 mum) restored ROV i

218 The identification of calcium channels and adrenoreceptors within cerebral vessels has led to commo