ライフサイエンスコーパス: adult human

1 lmonds in the growing pig as a model for the adult human.

2 to be restricted to liver and kidney in the adult human.

3 fat mass and higher lean mass in animals and adult humans.

4 mice with immune systems closer to those of adult humans.

5 fants and hibernating mammals-also exists in adult humans.

6 urbance, sleep duration, and inflammation in adult humans.

7 act (stomach and small intestine) of healthy adult humans.

8 studies demonstrate PGN in blood of healthy adult humans.

9 l to understanding why regeneration fails in adult humans.

10 Its normal habitat is the nasopharynx of adult humans.

11 gulating embryonic globin gene expression in adult humans.

12 n fetuses, and of normal fetal, newborn, and adult humans.

13 exploited for biological age estimation for adult humans.

14 decision-making in healthy, male and female adult humans.

15 the potential to be used therapeutically in adult humans.

16 tations to behavioral responses to threat in adult humans.

17 evaluate how cortical activity in 28 healthy adult humans (17 females) entrained to the auditory spee

18 le size of 50 or more patients; studies with adult humans 18 years or older; and studies published in

19 rtex and the contraction force of 17 healthy adult humans (7 females, 10 males).

20 Improved endurance exercise performance in adult humans after sprint interval training (SIT) has be

21 progenitors as organoids derived from single adult human alveolar epithelial type II (AT2) or KRT5(+)

22 ision drawing task and fMRI to investigate 8 adult human amputees with chronic (mean 33 years) unilat

23 higher than SCN10A transcript levels in both adult human and mouse heart tissue.

24 f pyramidal neurons in acute brain slices of adult human and mouse temporal cortex and probed the dyn

25 This study aimed to investigate whether adult humans and a distantly related habitually tool-usi

26 However, adult humans and animals that have evolved at altitude s

27 enic energy dissipation has been revealed in adult humans and has high clinical importance.

28 cortices varies several fold across healthy adult humans and is genetically heritable.

29 owed that brown adipose tissue is present in adult humans and may be exploited for its anti-obesity a

30 al perceptual learning paradigms, we trained adult humans and mice in an immersive audio game that ch

31 transcriptionally profiled healthy ENS from adult humans and mice.

32 ted feedback is compelling but restricted to adult humans and nonhuman animals.

33 an immunodeficiency virus (SIV) infection of adult humans and rhesus macaques.

34 hich co-locates to the main region of BAT in adult humans, and is indicative of thermogenesis.

35 uary 1, 2010, and June 1, 2015, inclusive of adult humans, and reported in the English language only.

36 tissue combust fuels for heat production in adult humans, and so constitute an appealing target for

37 l brain activity alteration in healthy young adult human APOE-epsilon4 carriers.

38 DLRs in adult humans are considered inactive epithelia, thought

39 th the capacity to regenerate, beta-cells in adult humans are minimally replicative, and therefore fa

40 ument a bias in head-turning to the right in adult humans, as tested in the act of kissing.

41 Using adult human astrocytes and motor neurons, Re et al. (201

42 In a group of older adult humans at the earliest stages of cognitive decline

43 Here, we found that adult human atrial epicardial cells were highly adipogen

44 dipocytes from stromal vascular fractions of adult human BAT from two individuals and globally analyz

45 erging questions, with a special emphasis on adult human BAT.

46 sized that targeting p57Kip2 could stimulate adult human beta cell replication.

47 herapeutic approach to beta cell deficiency, adult human beta cells have proven recalcitrant to such

48 hat can induce regeneration and expansion of adult human beta cells in vivo or ex vivo.

49 lated insulin secretion by both juvenile and adult human beta cells.

50 at conclusions on the lack of replication of adult human beta-cells are incorrect and suggest that ad

51 authentic replication with the expansion of adult human beta-cells could be demonstrated.

52 Some report that adult human beta-cells do not replicate, but we postulat

53 Surprisingly, adult human beta-cells express little or no PRLR.

54 ss failed to confer proliferative ability on adult human beta-cells in response to PRL.

55 an beta-cells are incorrect and suggest that adult human beta-cells replicate at a low but quantitati

56 We have devised an adult human bone marrow MSC (hMSC) delivery formula by i

57 It was previously demonstrated that adult human bone marrow-derived mesenchymal stem/stromal

58 ngle cell RNA sequencing on the study of the adult human brain and constitutes a first step toward a

59 Zika virus (ZIKV) infects fetal and adult human brain and is associated with serious neurolo

60 e we address this issue by using post-mortem adult human brain and spinal cord samples originating fr

61 Six tau isoforms are present in the adult human brain and they differ by the presence of 3(3

62 found in a yeast two-hybrid screen using an adult human brain cDNA library.

63 esonance imaging and network analysis in the adult human brain has identified a set of highly connect

64 Yet evidence on how training molds the adult human brain remains controversial, as fMRI at stan

65 present a multi-omic epigenetic atlas of the adult human brain through profiling of single-cell chrom

66 with all cell types in both adult mouse and adult human brain tissue.

67 ing of individual transcripts from fetal and adult human brain tissues we describe novel pri-miR-137

68 e transcriptomic atlases of the prenatal and adult human brain to determine where these genes are exp

69 ow numbers of neurons and glial cells in the adult human brain were reported and we examine the reaso

70 The comprehensive relations between healthy adult human brain white matter (WM) microstructure and g

71 ne expression and splicing are widespread in adult human brain, being detectable in all major brain r

72 ant population of GlyRs in the postnatal and adult human brain, brainstem and spinal cord.

73 ough tau isoforms are balanced in the normal adult human brain, imbalances in 3R:4R ratio have been t

74 otubule-binding repeats are expressed in the adult human brain, the pathological tau from different t

75 In the adult human brain, two tau isoforms are found in equal a

76 Using microglia isolated from the adult human brain, we demonstrate that myelin phagocytos

77 o glial progenitor cells derived from normal adult human brain, we found that the F2R gene encoding P

78 that TERT protein persists in neurons of the adult human brain, where it may have a protective role a

79 In vitro studies were conducted using adult human brain-derived oligodendrocytes challenged by

80 such responses using dissociated cultures of adult human brain-derived oligodendrocytes.

81 nctionality was identified for 4 loci in the adult human brain.

82 genes are expressed in the developmental and adult human brain.

83 that it might have a protective function in adult human brain.

84 n sulfate proteoglycan in the developing and adult human brain.

85 rate a unique pattern of neurogenesis in the adult human brain.

86 ed in oligodendrocytes and astrocytes in the adult human brain.

87 a reference framework of the developing and adult human brain.

88 ronounced differences between the foetal and adult human brain.

89 au and 4R-tau, which is equally expressed in adult human brain.

90 purify astrocytes from fetal, juvenile, and adult human brains and to maintain these cells in serum-

91 Adult human brains retain the capacity to undergo tissue

92 ene expression data sets from developing and adult human brains revealed that BCL11A expression patte

93 he study of adult mouse, adult zebrafish and adult human brains, and it may find many other applicati

94 dataset from 150 neuropathologically normal adult human brains, our method identifies eQTLs that wer

95 underpinning complex cognitive functions in adult human brains.

96 To understand the nature of adult human brown adipocytes at single cell resolution,

97 ent understanding of processing of threat by adult humans by revealing the characteristics of behavio

98 assessment of osteoblast recruitment during adult human cancellous bone remodeling is lacking.

99 progenitor cell [FhCPC]) and adult failing (adult human cardiac progenitor cell [AhCPC]) hearts, as

100 Prolonged mechanical unloading induces adult human cardiomyocyte proliferation, possibly throug

101 diomyocytes resemble, but are not identical, adult human cardiomyocytes and provide a new platform fo

102 ntractility of isolated healthy and ischemic adult human cardiomyocytes would be minimally sensitive

103 decisions and transitions from embryonic to adult human cell types during development are poorly und

104 e demonstrates the applicability of SCNT for adult human cells and supports further investigation of

105 human, being more prominent in the stenosed adult human central canal.

106 The adult human central nervous system (CNS) has very limite

107 MAPT, generates six protein isoforms in the adult human central nervous system (CNS).

108 A immunoreactivity was detected in fetal and adult human cerebral cortex.

109 neuronal marker immunotagging of nuclei from adult human cerebral cortex; 2) fluorescence-activated n

110 meterized based on representative indoor and adult human characteristics, the model is applied here t

111 ed transcriptome sequencing of 16 regions of adult human, chimpanzee, and macaque brains.

112 mpared with chondrocytes isolated from young adult humans, chondrocytes from older adults exhibited h

113 g to include six tau isoforms as seen in the adult human CNS.

114 Adult human cognition is supported by systems of brain r

115 We provided 280 adult human colon confocal Z-stacks from persons without

116 and single immune cells across the healthy, adult human colon, with paired characterization of immun

117 Plasma was obtained from adult human control and CA patients post-resuscitation,

118 y expressed in the limbal stem cell niche of adult human cornea, we assume that CHRDL1 plays a key ro

119 Adult human corneal endothelial cells are G1-arrested, e

120 e reconstructed >500 dendritic segments from adult human cortex obtained from autopsies.

121 velopment and was neuronally enriched in the adult human cortex.

122 Thus, adult human cortical microcircuits relay information at

123 olomics findings in a longitudinal cohort of adult human dengue patients across different infection s

124 lly, P12 bound PDGF-BB (KD=200 nM), enhanced adult human dermal fibroblast (AHDF) survival under seru

125 rived growth factor BB (PDGF-BB) and promote adult human dermal fibroblast (AHDF) survival under stre

126 rticularly in the areas of BAT physiology in adult humans, developmental lineages of brown adipose ce

127 rom the fovea and peripheral retina of seven adult human donors.

128 n our ancestors but normally absent from the adult human - during normal embryonic human development,

129 We show that in healthy adult human ears, deeper tissue penetration of SWIR ligh

130 e report a novel method for the isolation of adult human epithelial stem cells (hEpiSCs) from the epi

131 mixed meal (320 mmol N) consumed by healthy adult humans equipped with a triple-lumen sampling tube

132 d the chromosomal architectures of fetal and adult human erythroblasts and found that, globally, chro

133 o the fetal gamma-globin promoter in primary adult human erythroblasts increases gamma-globin promote

134 to a reversion of gamma-globin silencing in adult human erythroblasts.

135 The bony pelvis of adult humans exhibits marked sexual dimorphism, which is

136 owever, TNC immunolocalization in the JCT of adult human eyes suggests that certain areas of the TM a

137 Adult humans fail to regenerate their hearts following i

138 rapid, highly reproducible method to convert adult human fibroblasts from living ALS patients to indu

139 dedifferentiation and lineage conversion of adult human fibroblasts into functional endothelial cell

140 ngle VEE-RF RNA transfection into newborn or adult human fibroblasts resulted in efficient generation

141 as used to investigate the BCR repertoire of adult humans following immunization and to test the hypo

142 (n = 7) and SPECT/CT (n = 74) scans done in adult humans for parathyroid imaging were reviewed for u

143 dopamine synthesis capacity in healthy older adult humans free of amyloid pathology, relative to youn

144 Adult humans frequently engage in the reciprocal exchang

145 t between the nasopharynx and bloodstream of adult humans: glucose is absent from the nasopharynx, wh

146 tanding of the underlying structure of early adult human haematopoiesis.

147 Even though the existence of BAT in adult humans has been widely appreciated, its cellular o

148 Adult humans have brown fat, but the amounts and activit

149 is paralleled only by the confirmation that adult humans have heat-dissipating brown adipose tissue,

150 on the minimal regenerative potential of the adult human heart and the limited availability of human

151 mphasizing the regeneration potential of the adult human heart and the mechanisms involved.

152 The adult human heart does not regenerate significant amount

153 The adult human heart is an organ with low regenerative pote

154 or cardiomyocyte regeneration in the healthy adult human heart is fundamentally relevant for both myo

155 The major alpha isoform in the adult human heart is Na(V)1.5, and germline mutations in

156 The adult human heart is unable to regenerate after various

157 rstanding the maturation and pathogenesis of adult human heart muscle cells, and this concept may be

158 cting enhancers active in the developing and adult human heart, an organ whose impairment is a predom

159 ocytes closely mimicked the non-failing (NF) adult human heart.

160 The low regenerative capacity of adult human hearts has thus far limited the available th

161 d (left ventricular assist device treatment) adult human hearts.

162 presses adult beta-globin gene expression in adult human hematopoietic precursor cells, but the under

163 Adult human hepatocytes were transplanted into Fah(-/-)/

164 ed the pattern of SCGN immunostaining in the adult human hippocampal formation (DG, CA1, CA2, CA3, su

165 extracted along the longitudinal axis of the adult human hippocampus can be predicted within 2mm usin

166 se to combined transendocardial injection of adult human hMSCs (bone marrow-derived mesenchymal strom

167 Diffusion of the probe particles in adult human ileal mucus and adult pig jejunal and ileal

168 N scales linearly to cell surface in adult humans, in adult and developing mice, and in mice

169 in which 5-hmC regulates differentiation of adult human intestine and 5-hmC alterations contribute t

170 ber of peripheral blood B cells in a healthy adult human is on the order of 5 x 10(9), the circulatin

171 The presence of active neurogenic niches in adult humans is controversial.

172 a-cell formation and coproduced with MAFA in adult human islet beta-cells, bound MLL3 and MLL4 comple

173 The present study uses cultured adult human islets devoid of amyloid to examine conditio

174 ndent hPSC lines, human fetal pancreata, and adult human islets points to two major conclusions: (i)

175 the cells, in vitro differentiated cells and adult human islets were compared by global proteomic ana

176 ced in culture and released from quiescence, adult human kidney epithelial cells (hKEpCs), uniformly

177 steine (NAC) reduces the incidence of DGF in adult human kidney transplant recipients.

178 ive principal cells of the distal nephron of adult human kidney.

179 enal EGFR expression were detected in normal adult human kidneys.

180 Laboratory mice--like newborn, but not adult, humans--lack effector-differentiated and mucosall

181 ymphocytic leukemia (CLL) is the most common adult human leukemia.

182 ion in cognitive test performance across the adult human life span.

183 ing) beyond their acoustic (surface) form in adult human listeners.

184 +) population of freshly isolated foetal and adult human liver identifies diverse gene expression sig

185 ree-dimensional liver buds against fetal and adult human liver single-cell RNA sequencing data, and f

186 pithelial cell phenotypes preexist in normal adult human livers, which might provide an alternative e

187 icited modest induction of Ralpha2 in normal adult human lung fibroblasts, but found that prostagland

188 vitro and in vivo grown HLOs with fetal and adult human lung tissue, we found that in vivo transplan

189 s that were remarkably similar to the native adult human lung.

190 ndicate the existence of beige adipocytes in adult humans, making this cell type an attractive therap

191 lations predict that 370 MBq of (51)Mn in an adult human male would yield an effective dose equivalen

192 Adult human mesenchymal stem cells show structural rearr

193 of children with ASD and stimulates cultured adult human microglia to secrete the proinflammatory mol

194 eport, we show that pretreatment of cultured adult human microglia with recombinant IL-38 (aa3-152, 1

195 microglia and recapitulate heterogeneity of adult human microglia.

196 5) neonatal rat cardiomyocytes and 7% or 28% adult human MSCs (hMSCs) in diffuse or clustered distrib

197 ergy-consuming brown adipose tissue (BAT) in adult humans, much effort has been devoted to exploring

198 We explored POMK expression in fetal and adult human muscle and identified widespread expression

199 nistic insights into both Wnt signalling and adult human myogenic progenitor differentiation.

200 A sample of nonclinical adult humans (N = 518) performed three cognitive tasks (

201 Pneumococcal adherence to adult human nasal fluid was seen only by isolates expres

202 We conclude that in adult human neocortex spine positions are mostly random.

203 ndogenous adult stem/progenitor cell, called adult human neural progenitor (AHNP) cells, that we foun

204 here are no disease-modifying treatments for adult human neurodegenerative diseases.

205 his limits their application to the study of adult human neuromuscular junction (NMJ) development, a

206 Both AS3MT(d2d3) and BORCS7 are expressed in adult human neurons and astrocytes, and they are upregul

207 h expression has not been reported in normal adult human neurons.

208 cal and carbon-14 dating approaches, that in adult humans new neurons integrate in the striatum, whic

209 offers a simple method to model and evaluate adult human NMJ de novo development or disease in cultur

210 Here we report the conversion of adult human nonendocrine pancreatic tissue into endocrin

211 viously identified NP and NC marker genes in adult human NP cells from a range of ages and degenerate

212 HSV infection of adult humans occasionally results in life-threatening he

213 We show in adult humans of either sex that single trial EEG activit

214 dies of the mechanisms underlying subsequent adult human oligodendrocyte cell death.

215 in mouse and increases both adult mouse and adult human oligodendrocyte progenitor cell (OPC) differ

216 Under basal conditions, adult human OLs were less metabolically active than thei

217 Using fMRI, we scanned 36 healthy young adult humans on a novel two-back task requiring working

218 tudy compares the relative susceptibility of adult human OPCs and mature OLs to injury in actively de

219 epair, plus demonstration of its activity on adult human OPCs, leads us to propose dual PDE7-GSK3 inh

220 also report anti-Foxo3 immunofluorescence in adult human outer hair cells.

221 port the existence of germline stem cells in adult human ovaries, thereby reinforcing the dogma of a

222 Adult human pancreatic beta cells are refractory to curr

223 21 facilitates cell cycle entry of quiescent adult human pancreatic beta cells.

224 demonstrating that alpha cells derived from adult human pancreatic islets can be reprogrammed to bec

225 f Oldowan tool-making skills along chains of adult human participants (N=184) using five different tr

226 We recorded magnetoencephalography from 20 adult human participants with ASD and 20 matched control

227 Testing adult human participants with high-density EEG, we show

228 y (RSFC) analyses, with data from 33 healthy adult human participants, we demonstrate that (1) the VW

229 We find that these principles also obtain in adult human perception.

230 Eleven healthy adult humans performed a joystick visuomotor adaptation

231 In the present study, male and female adult humans performed an implicit learning task across

232 ns that are representative of those found in adult human plasma.

233 Over 90% of the adult human population is chronically infected with the

234 h RNA fractions from homogenate prenatal and adult human postmortem cortex using poly(A)+ and Ribo-Ze

235 Therefore, we sought to develop an adult human primary cardiomyocyte contractility model th

236 In this study, comparison of neonatal versus adult human progenitors has identified a blockade in the

237 Werner syndrome (WS) is the canonical adult human progeroid ('premature aging') syndrome.

238 The study of congenitally deaf adult humans provides an opportunity to examine neuroana

239 e closely reflected the immune signatures of adult humans rather than neonates, altered resistance to

240 why cardiac regenerative capacity is lost in adult humans remains an enigma.

241 ir lifetime) in up to 22,861 male and female adult human research participants of European ancestry.

242 eotypic arrangement is also found across the adult human retina, with the notable exception that ChAT

243 B-crystallin (alphaB) is exported out of the adult human retinal pigment epithelial cells (ARPE19) pa

244 t epithelium and choroid of light-responsive adult human retinas, and performed histochemistry.

245 K4a expression, leading to RGC senescence in adult human retinas.

246 Furthermore, adult human salivary glands damaged by irradiation also

247 xisting culture techniques to prepare viable adult human sensory neurons for functional studies.

248 In adult humans, short-term monocular deprivation strongly

249 stem/progenitor cells (MDSPCs) isolated from adult human skeletal muscle (hMDSPCs) can adopt neuronal

250 n fetal skeletal muscle and compared them to adult human skeletal muscle and rabbit psoas muscle.

251 ogenesis during development, but its role in adult human skeletal muscle remains unknown.

252 are differentially expressed in fetal versus adult human skeletal muscle tissue.

253 Adult human skin biopsies were obtained from volunteers

254 Adult human skin fibroblasts were exposed for 18 h to th

255 Adult human skin from reduction mammoplasties was prepar

256 Adult human skin is an appropriate model for these virus

257 els used fetal tissue; here, we developed an adult human skin model to study VZV and HCMV in culture

258 t time, we showed HCMV successfully grows in adult human skin, as does VZV.

259 B1 accumulation, whereas in newborn mice and adult human skin, we report LC3 puncta coincident with m

260 cles in mucus under conditions mimicking the adult human small intestinal environment.

261 mediators of fast synaptic inhibition in the adult human spinal cord and brainstem.

262 We found that the infant and adult human spinal cord contains ependymal cell types th

263 Four of the loci were also associated with adult human stature, but these remained associated with

264 nin-expressing interneurons are added to the adult human striatum at a substantial rate.

265 eads between conventional pigs (growing) and adult human subjects (with the metabolic syndrome).

266 In a sample of 160 adult human subjects with a broad IQ range, we investiga

267 We now report that, in male and female adult human subjects, encoding and later consolidation o

268 but capacity-limited) mechanisms in healthy adult human subjects.

269 if they evaluated vital signs monitoring in adult human subjects.

270 uivocally the existence of functional BAT in adult humans, suggesting that many humans retain some fu

271 microvessels from four cryopreserved normal adult human sural nerves referenced to the Genome Refere

272 ression, and catabolism syndrome observed in adult human surgical sepsis survivors.

273 ermined the energy utilization properties of adult human surgically derived OLs cultured under either

274 It is unknown whether adult human synapses are more efficient in transferring

275 e the immune system, and the availability of adult human synovial fibroblasts are likely to provide n

276 differentiation status and ECM production in adult human tendons and ligaments.

277 ed genes, species which can also be found in adult human testis.

278 B cells comprise a much smaller fraction in adult humans than mice.

279 tive functions of the upper tract of healthy adult humans: the TIM-1.

280 and the 1-CoPK model was parametrized for an adult human to calculate HLB from HLT.

281 avioral training enables monaurally-deprived adult humans to exploit both of these adaptive processes

282 rategies for activating BAT thermogenesis in adult humans to increase whole-body energy expenditure.

283 ch kinetics approaching reported values from adult human trabeculae.

284 titalker backgrounds, the auditory cortex of adult humans tracks the attended speech stream rather th

285 or-posterior axis using neuroimaging data of adult human twins.

286 nhibition triggers homeostatic plasticity in adult human V1 after a brief period of abnormal visual e

287 dence of rapid topographic reorganization in adult human V1, and the strongest evidence yet that visu

288 of short-term topographic reorganization in adult human V1.

289 Compared with adult human ventricular cardiomyocytes, T-tubules in T3+

290 data in a predictive in silico model of the adult human ventricular myocyte.

291 oit the intrinsic residual plasticity of the adult human visual cortex.

292 We found that the adult human visual system is tuned to these contingencie

293 infused as an intravenous bolus in 7 healthy adult human volunteers at </=2 mg/kg to provide circulat

294 performed high-resolution 7 Tesla fMRI while adult human volunteers attended either to the numerosity

295 of 400 mg and 600 mg administered in healthy adult human volunteers.

296 GABA concentration in V1 of adult humans was measured using ultra-high-field 7T magn

297 ounts for up to 70% of bone marrow volume in adult humans, we examined the adipocyte-leukemia cell in

298 In healthy adults humans, we investigated the impact of effortful,

299 s were recorded from 20 right-handed healthy adult humans who listened to five different recorded sto

300 ZIKV is considered a transient infection in adult humans without marked long-term effects, there may