ライフサイエンスコーパス: adult mice

1 producible retinal blood flow measurement in adult mice.

2 rting cells within a balance epithelium from adult mice.

3 neurons (D1-MSNs) in both juvenile and young-adult mice.

4 the essential autophagy gene Atg7 throughout adult mice.

5 not PFC impaired trace fear conditioning in adult mice.

6 ration upon partial hepatectomy in young and adult mice.

7 taste cells in the circumvallate papillae of adult mice.

8 cell Kindlin-2 causes diabetic phenotypes in adult mice.

9 unctions in different organs of juvenile and adult mice.

10 abundant in the MZ of neonatal compared with adult mice.

11 and activation during tissue homeostasis in adult mice.

12 TINs) in male preadolescent, adolescent, and adult mice.

13 ch enhanced associative fear memory in young adult mice.

14 rising >=90% of the hepatocyte population in adult mice.

15 s expressed in the cochlea of developing and adult mice.

16 rtex and increases seizure susceptibility in adult mice.

17 ductive performance or general well-being of adult mice.

18 e a controlled partial depletion of BACE1 in adult mice.

19 cs were measured in neonatal (P14) and young adult mice.

20 amic Agrp neurons regulate food ingestion in adult mice.

21 immunoproteasome activity is dispensable in adult mice.

22 ted monoamine levels in the PFC of CD38(-/-) adult mice.

23 , the levels were similar in male and female adult mice.

24 ance of skeletal muscle mass and function in adult mice.

25 allosum, and primary somatosensory cortex of adult mice.

26 etal muscle mass and contractile function in adult mice.

27 nexin 43 (Cx43) in OECs in both juvenile and adult mice.

28 ng tumors and causes alveolar destruction in adult mice.

29 litis through inducible deletion of Enpp2 in adult mice.

30 was decreased at P14 but increased in young adult mice.

31 d with invasive electrophysiology testing in adult mice.

32 nt antimicrobial immune response compared to adult mice.

33 lasticity and learning and memory defects in adult mice.

34 nergistically affected recognition memory in adult mice.

35 isualized whole-body neuronal projections in adult mice.

36 ong-term potentiation (LTP) abnormalities in adult mice.

37 c cells significantly reduces bone volume in adult mice.

38 illustrates the complexity of GPe neurons in adult mice.

39 etion or glucose tolerance in lean, chow-fed adult mice.

40 but increased complex III subunit 9 in young adult mice.

41 mage and reconstruct cleared lung lobes from adult mice.

42 B integrity under pathological conditions in adult mice.

43 cose clearance and exercise capacity in lean adult mice.

44 tter system in the prelimbic cortex (PrL) of adult mice.

45 cally with observed PT-promoted pathology in adult mice.

46 on mediated-kidney specific gene transfer in adult mice.

47 gait alterations in Chn1KO/KO and Epha4KO/KO adult mice.

48 n restoring the decreased RANKL/OPG ratio in adult mice.

49 o2(+) vagal sensory neurons causes apnoea in adult mice.

50 l (RES) induces beige adipocyte formation in adult mice.

51 tially rescue DMM-induced OA-like defects in adult mice.

52 rmore, IL-3 increases the serum OPG level in adult mice.

53 memory impairment and neurodegeneration, in adult mice.

54 ed cold-induced beige adipocyte formation in adult mice.

55 e to eliminate FMRP only in the PFC alone of adult mice.

56 ling stimulates neurogenesis in unchallenged adult mice.

57 Vectors were IVT injected into the eyes of adult mice.

58 spectively or simultaneously, throughout the adult mice.

59 factor more abundant in pre-weaning than in adult mice.

60 hology and a functional decline in fetal and adult mice.

61 th an extended period of food restriction in adult mice.

62 n neonatal cochlear explants, and in vivo in adult mice.

63 lly in intestinal epithelial cells (IECs) of adult mice.

64 es the acquisition of motor skills in normal adult mice.

65 d branching processes within the striatum of adult mice.

66 in promotes cardiac regeneration after MI in adult mice.

67 paired with cocaine in male, but not female, adult mice.

68 responses, more similar to those observed in adult mice.

69 ubpopulation of hepatocytes that persists in adult mice.

70 t baseline cardiac size or function in young adult mice.

71 er hair cells of pre-hearing (P7) but not in adult mice.

72 induces proliferation in supporting cells of adult mice.

73 stem cells located within the bone marrow of adult mice.

74 ecreased social interactions in juvenile and adult mice.

75 eding and anemia in inducible ALK1-deficient adult mice.

76 dopamine neurons in isoflurane-anaesthetized adult mice.

77 ioid-induced respiratory depression in awake adult mice.

78 ologically evoked neuronal activity in awake adult mice.

79 al proteomic analysis was performed in young adult mice (14 weeks).

80 V-CRISPR is immunogenic when administered to adult mice(7); however, humoral and cellular immune resp

81 In adult mice, a single-cycle HSV candidate vaccine deleted

82 essing neurons or reducing poly(GR) level in adult mice after disease onset rescued poly(GR)-induced

83 glia to proliferate and generate neurons in adult mice after injury.

84 collagen patches improves heart function in adult mice after myocardial infarction by a cardioprotec

85 on of agrin promotes cardiac regeneration in adult mice after myocardial infarction, although the deg

86 In adult mice, an ~3-fold increase in the steady-state IL-3

87 bacter rodentium colitis (CC) was induced in adult mice and colonic neurons were quantified.

88 deleted either Pax2, Pax8, or both genes in adult mice and examined the resulting phenotypes and cha

89 we develop two methods to profile the ENS of adult mice and humans at single-cell resolution: RAISIN

90 litis promotes rapid enteric neurogenesis in adult mice and humans through differentiation of Sox2- a

91 tic signature were investigated in germ-free adult mice and in dams colonized with HC, pre-UC, or pos

92 dual neurons in the auditory cortex of awake adult mice and is associated with long-term improvement

93 lls is the major source of new beta-cells in adult mice and juvenile humans.

94 corticosterone (CORT) treatment was given to adult mice and led to rapid insulin resistance and adapt

95 tlas of the transcriptome of limb tendons in adult mice and rats using systems biology techniques.

96 nced global DNA methylation patterns in both adult mice and their offspring and engendered behavioral

97 of expression of abcc9, a pericyte marker in adult mice and zebrafish, occurs almost coincidentally w

98 led markers in a 1-mm thick brain slice from adult mice, and 14 days were required for detecting anti

99 that Lkb1 was essential for the survival of adult mice, and autophagy activation could temporarily c

100 idase inhibitors into spinal cord lesions of adult mice, and found that both types of microglia signi

101 epithelium (Runx1) and endothelium (Alk1) in adult mice, and is accompanied by prolonged HFSC quiesce

102 behavior and long-term hippocampal memory in adult mice, and males showed significantly more improvem

103 and turnover of the olfactory epithelium in adult mice, and rosette-bearing cells often have free ce

104 gene expression in developing zebrafish and adult mice, and this pathway operates in cancer cells fr

105 ds enabling kidney-specific gene transfer in adult mice are needed to develop new therapies for kidne

106 ow that oral administration of DHA to normal adult mice as lysophosphatidylcholine (LPC) (40 mg DHA/k

107 K1 KO significantly decreased body weight of adult mice as well as increased general locomotor activi

108 uimod (IMQ)-induced epidermal hyperplasia in adult mice as well as naturally occurring hyperprolifera

109 Using both postnatal and adult mice, as well as embryonic zebrafish, we demonstra

110 of sepsis; survival studies in juvenile and adult mice, assessment of lipoprotein fractions, bacteri

111 pup survival and well-being, and housing of adult mice at densities of up to twice current Guide rec

112 of Ccl2, Ccl3, and Ccl4, when compared with adult mice, at 72 h postinfection.

113 In adult mice, attenuation of hippocampal ACSS2 expression

114 inactivated the Barr1 gene in beta-cells of adult mice (beta-barr1-KO mice).

115 P disorder are also present in the brains of adult mice born from dams prenatally restraint stressed

116 Here we asked whether neurons in adult mice, born during the final 5 days of chronic soci

117 t, progressive myelin thinning in the CNS of adult mice (both male and female).

118 lectrophysiology and immunohistochemistry in adult mice (both sexes) to define first, the boundaries

119 ruses cause diarrhea in interferon-deficient adult mice but these hosts also develop systemic patholo

120 fying K(+) (GIRK) channels in SAN cells from adult mice, but A(1)R-GIRK responses are smaller and slo

121 with homeostatic functions that is stable in adult mice, but declines in numbers during ageing and is

122 severity of influenza A virus infections in adult mice by reducing the number of alveolar epithelial

123 Large skin wounds in adult mice can heal by regenerating new hair follicles a

124 associated with reduced MZ B cell numbers in adult mice cause increased cDC2 occupancy of the MZ.

125 els, we found that induced Bccip deletion in adult mice caused an acute intestinal epithelial denudat

126 of life, we show that while dysregulation in adult mice causes a mild systemic autoinflammatory disea

127 Conditional autophagy deficiency in adult mice causes liver damage, shortens life span to 3

128 d that EphA4 KO in young mice, but not older adult mice, causes defects in muscle function, consisten

129 In contrast, adult mice cleared the infection.

130 t YAP/TAZ dramatically disappear from SCs of adult mice concurrent with axon degeneration after nerve

131 r divisions, but show that primitive HSCs of adult mice continue to cycle rarely.

132 In vivo studies in adult mice demonstrated the successful delivery of genom

133 of GABAB receptors from dopamine neurons in adult mice did not affect general or morphine-induced lo

134 ditional knockout (CKO) in the endothelia of adult mice did not affect homeostatic BBB integrity, but

135 However, the ovaries of PitERtgKO adult mice displayed a more overt cystic and hemorrhagic

136 In contrast, asparaginase-treated adult mice displayed greater variability in liver functi

137 dorsal cerebellar vermis granule neurons in adult mice disrupts enhancer-promoter interactions, acti

138 at intravitreal injection of griseofulvin in adult mice does not disrupt retinal vasculature, functio

139 rexpression of Bmp10 in endothelial cells of adult mice dramatically enhanced formation of contractil

140 viors were quantified based on time spent by adult mice engaging in social behaviors toward a juvenil

141 Cav-1 overexpression in adult mice enhanced dendritic arborization within the ap

142 After Igf1 deletion at birth or in young adult mice, evaluations of muscle physiology and glucose

143 for cardiac development as Hdn-heterozygous adult mice exhibit hyperplasia in the right ventricular

144 nimals are fertile and develop normally, and adult mice exhibit no overt tissue abnormalities.

145 Nkx6.2-null embryos, neonates and adult mice exhibited alterations of locomotor pattern an

146 ts, 2) antipsychotic-exposed monkeys, and 3) adult mice exposed prenatally to maternal immune activat

147 eviously, we reported that 14-week-old young adult mice exposed to hyperoxia as newborns had spatial

148 Adult mice expressing nuclear, but not cytoplasmic, CELF

149 in Alzheimer-like brain alterations in young adult mice expressing only non-mutated human tau.

150 on systemic essential metal distribution in adult mice fed a high-fat diet (HFD) were examined.

151 In adult mice fed normal chow, skeletal muscle expression o

152 In adult mice, FLARE also gave light- and motor-activity-de

153 Cxcr2 to be silenced in oligodendrocytes in adult mice following treatment with tamoxifen.

154 In adult mice, fusion of vertebral bodies and of spinous an

155 eta-arrestin-2 gene, barr2, in beta-cells of adult mice greatly impairs insulin release and glucose t

156 However, whether B cell depletion in normal adult mice has the same effect on memory responses by CD

157 hown not to be required for hearing in young adult mice, IHCs from Cx30 knock-out mice exhibited a co

158 stem protein, alone or combined with LcrV in adult mice immunized intranasally.

159 as knocking down NEAT1 in both young and old adult mice improved behavior test-associated memory.

160 terminal fields in adult control mice and in adult mice in which the alpha-subunit of the epithelial

161 response to lipopolysaccharide challenge in adult mice in which the EC expressed TRPM2 is conditiona

162 certa bidirectionally regulate sleep time in adult mice, in part through hypocretin-dependent mechani

163 12 transgenic mouse lines in a total of 243 adult mice, in response to a systematic set of visual st

164 rsely, administration of a Piezo1 agonist to adult mice increased bone mass, mimicking the effects of

165 ic mice and short-term inhibition of shn3 in adult mice increases bone mass.

166 p25/p35 ratio in the cortex of preCGG young adult mice indicate abnormal Cdk5 regulation.

167 Depletion of Cdc42 in adult mice induced a significant expansion of the apical

168 ta receptor, TGFBR2, in retinal microglia of adult mice induced abnormal microglial numbers, distribu

169 However, its systemic inactivation in adult mice induces T-cell acute lymphoblastic lymphoma (

170 tine exposure potentiates drug preference in adult mice, induces alterations in calcium spike activit

171 In adult mice induction of EC-specific cox10 gene deletion

172 Transient iron overload in adult mice infected with E. coli resulted in 100% mortal

173 ne allele of Dkk1 in Osx-expressing cells in adult mice inhibited the recovery of BM stem and progeni

174 elial cell (LEC)-specific deletion of Ilk in adult mice initiates lymphatic vascular expansion in dif

175 d antibody neutralization in immunocompetent adult mice inoculated in the rear footpads.

176 elial cell-specific inactivation of Ephb4 in adult mice is compatible with survival, but leads to rup

177 requirement for laminin-gamma1 synthesis in adult mice is dependent on a tissue-specific basal rate

178 n the other hand, systemic SHOC2 ablation in adult mice is relatively well tolerated.

179 osteoclast formation and bone remodeling in adult mice is unknown.

180 eas SULT1E1 is expressed low in the liver of adult mice, it is induced by phenobarbital (PB) treatmen

181 Adult mice lacking beta-arrestin 1 selectively in hepato

182 Both juvenile wild-type mice and adult mice lacking ngr1 in L4 displayed OD plasticity th

183 rate that TRADD is critical in perinatal and adult mice lacking RIPK1 and RIPK3, which has not been a

184 ubunits in VTA DA neurons of male and female adult mice, leading to enhancement (GIRK2) or suppressio

185 Lztr1 deletion in blood vessels of adult mice leads to abnormal vascular leakage.

186 t cardiomyocyte-specific deletion of Brd4 in adult mice leads to acute deterioration of cardiac contr

187 deletion of dopamine neuron-derived IGF-1 in adult mice leads to decrease of dopamine content in the

188 isera or CD4(+) T cells from PhtD-vaccinated adult mice led to a nonsignificant reduction in NP colon

189 Genetic depletion of endothelial Eng in adult mice led to a significant reduction in mean aortic

190 However, expression of these genes in adult mice led to different tumor phenotypes.

191 more, selective Ntrk2 deletion in the DMH of adult mice led to hyperphagia, reduced energy expenditur

192 further found that acute deletion of Lkb1 in adult mice led to impaired intestinal barrier function,

193 Deletion of Pax6 in beta cells of adult mice led to lethal hyperglycemia and ketosis that

194 Endothelial deletion of Has2 in adult mice led to substantial loss of the glycocalyx str

195 In adult mice, lung-localized, tissue-resident memory T cel

196 Moreover, silencing IGL(NPY) neurons in adult mice mimicked the deficits that were induced by ab

197 In normal adult mice, most mature B cells are enriched for Nod1 up

198 nhancement of plasticity by LRx in binocular adult mice (Murase et al., 2017).

199 nd, HIF-1alpha was deleted in NTS neurons in adult mice (NTS-HIF-1alpha(-/-) ) by microinjecting aden

200 apping to interrogate local LCIC circuits in adult mice of both sexes and found that input patterns a

201 In adult mice of either sex, we find that MD prevents the e

202 Using thalamic slices derived from adult mice of either sex, we recorded slow forms of rhyt

203 of cultured utricles that were isolated from adult mice of either sex.

204 OA targets are frequently performed on young adult mice only.

205 In adult mice, pDC depletion predisposed to severe bronchio

206 Here, in adult mice previously stressed during puberty, allopregn

207 c relevance, temporal deletion of miR-142 in adult mice prior to transplantation of a fully MHC misma

208 selective knockout of Tet1 in NAc neurons of adult mice produced antidepressant-like effects in sever

209 Nedd4-2 (Nedd4l) in lung epithelial cells in adult mice produces chronic lung disease sharing key fea

210 ple, we here show that in the hippocampus of adult mice, quiescent neural precursor cells (NPCs) main

211 mbing fibre collateral excitation is weak in adult mice, raising the question of whether the primary

212 fficient to impair memory formation in young adult mice, recapitulating observed memory deficits in o

213 revented closure of the critical period, and adult mice remained sensitive to brief monocular depriva

214 ditional Ssb1/Ssb2 double knockout (cDKO) in adult mice resulted in acute lethality due to bone marro

215 EC-specific deletion of talin in adult mice resulted in impaired stability of intestinal

216 report that disruption of the Rasa1 gene in adult mice resulted in loss of LV endothelial cells (LEC

217 We report that inactivation of Epas1 in adult mice resulted in selective abolition of glomus cel

218 Disruption of Rasa1 in adult mice resulted in venous hypertension and impaired

219 cing OGT knock-out in the sensory neurons of adult mice results in a similar decrease in nerve fiber

220 xclusively in the pancreatic acinar cells of adult mice results in decreased overall pancreatic weigh

221 e show that conditional knockout of Ttbk2 in adult mice results in degenerative cerebellar phenotypes

222 ort that TAK1 loss from endothelial cells in adult mice results in intestinal and hepatic vascular de

223 trate that Gsalpha deficiency in JG cells of adult mice results in kidney injury, and suggest that JG

224 of the key ciliary trafficking gene Ift88 in adult mice results in nearly identical cerebellar phenot

225 icrobiota in antibiotic-treated or germ-free adult mice results in significant deficits in fear extin

226 Unbiased behavioral profiling of adult mice revealed abnormalities in approach behavior t

227 g on either subunit in the organ of Corti of adult mice revealed immunopuncta clustered at the synapt

228 sponses to Bordetella pertussis infection in adult mice, revealing that type I and III IFN pathways m

229 ducible endothelial-specific loss of Phd2 in adult mice ruled out a requirement for PHD2 signaling in

230 Heterozygous adult mice showed increased SAN recovery times after pac

231 haematopoietic repopulation of myeloablated adult mice similarly to bone marrow cells.

232 e switch to I438K expression is tolerated in adult mice, sparing normal cells but allowing for an enh

233 ic-polycytidylic acid injections, but not in adult mice subjected to maternal immune activation in ut

234 Adult mice subjected to transverse aortic constriction (

235 endothelial-specific disruption of Piezo1 in adult mice suppressed the expression of multiple Notch1

236 In adult mice, tdTom(+) cells could be readily detected at

237 microscopic immunolabeling in the PL-PFC of adult mice that had received Delta9-THC only during adol

238 We show that adult mice that lack ipRGCs from the early postnatal sta

239 paB-related messenger RNA levels was seen in adult mice that received daily polyinosinic-polycytidyli

240 In adult mice that were proficient in a skilled reaching ta

241 Here, we show, in adult mice, that a subretinal injection of a lentivirus

242 we show in 2- to 3-week-old young neurons of adult mice, that brief-burst activity in glutamatergic f

243 In adult mice, this synaptopathy is immediate and largely i

244 ve shown that stabilization of HIF levels in adult mice through PHD2 enzyme silencing by RNA interfer

245 wo photon imaging in somatosensory cortex of adult mice to define the kinetics and specificity of mye

246 ith a histone deacetylase inhibitor, enables adult mice to generate neurons from MG after retinal inj

247 gene specifically in the skeletal muscle of adult mice to generate skeletal muscle-specific Brca1 ho

248 However, isolation of fresh ECs from adult mice to investigate this further is challenging.

249 dFBs in culture and increased resistance of adult mice to S. aureus infection.

250 produce and intravenously administer AAVs to adult mice to specifically label and/or genetically mani

251 Here we report that in adult mice trained in fear extinction, the DNA modificat

252 Adult mice transduced with Trpm4-targeted short hairpin

253 Adult mice treated prenatally displayed reduced levels o

254 roach to characterize vascular remodeling in adult mice using Adipo-Clear in combination with light-s

255 d STIM1-KD (STIM1 knockdown) was achieved in adult mice using an alphaMHC (alpha-myosin heavy chain)-

256 for the isolation and culture of MLECs from adult mice using collagenase I-based enzymatic digestion

257 amate cotransmission onto principal cells in adult mice using paired recording and optogenetic approa

258 NCS-Rapgef2 gene deletion in the NAc in adult mice, using adeno-associated virus-mediated expres

259 sceptibility to depression-like behaviors in adult mice, using the chronic social defeat stress (CSDS

260 combinase system and caused tendon growth in adult mice via mechanical overload of the plantaris tend

261 nditional knockout (KO) of Fat3 in brains of adult mice was attempted using the inducible Thy1Cre(ER(

262 apses in male preadolescent, adolescent, and adult mice was evaluated using an optogenetic approach.

263 matory response in the skin and the lungs of adult mice was observed following sensitization and chal

264 om C57BL/6 mouse embryos, neonatal mice, and adult mice was performed to evaluate for primary cilia.

265 Genetic ablation of the Lamc1 gene in adult mice was rapidly lethal.

266 Activation of the p.Arg1872Trp mutation in adult mice was sufficient to generate seizures and death

267 tion of VAChT in the dorsomedial striatum of adult mice was sufficient to phenocopy maladaptive eatin

268 -loxP-mediated conditional gene targeting in adult mice was used.

269 cell mRNA counts across different tissues of adult mice, we find that peak transcription levels are a

270 of retrogradely labeled thalamic neurons in adult mice, we identify three major profiles of thalamic

271 g permeabilized cardiomyocytes isolated from adult mice, we modified the standard CRC assay by specif

272 In adult mice, we observed that TET3 is present in mature n

273 In contrast to adult mice, we show that isolation from the nursing nest

274 ockout in olfactory epithelial stem cells in adult mice, we show that lamin B1 deficient neurons exhi

275 mice with the cecal contents of neonatal and adult mice, we show that the neonatal microbiota is unab

276 ning after manipulation of the microbiota in adult mice were associated with defective learning-relat

277 Neonatal and adult mice were epicutaneously sensitized with allergen

278 Adult mice were intranasally challenged with PBS or mixe

279 Early adolescent and young adult mice were tested on an array of assays to test for

280 capitulating observed memory deficits in old adult mice, whereas knocking down NEAT1 in both young an

281 ctivity in Engrailed-2 knock-out (En2 (-/-)) adult mice, which show a lower expression of Fmr1 and an

282 specific ablation of Nptn gene expression in adult mice, which shows that neuroplastins are indispens

283 d significantly more total iron than that of adult mice, which was sufficient to support enhanced E.

284 inked proton leak in both neonatal and young adult mice while complex I function was decreased at P14

285 Daily gavage of conventional C3H/HeN adult mice with 10(9) commensal E coli induced visceral

286 e inferior colliculus and auditory cortex in adult mice with a near-complete loss of auditory nerve a

287 are minimally affected by TDG knockdown, and adult mice with conditional knockout of Tdg are viable.

288 imary somatosensory cortex (barrel field) of adult mice with different cell type specific genetic del

289 To test this hypothesis, we infected young adult mice with either of two genetically distinct, pers

290 show that modeling this impairment in young adult mice with normal cognitive performance disrupts lo

291 Notably, treatment of adult mice with rapamycin, which inhibits MTOR, reverses

292 Furthermore, adult mice with reduced DAT expression (DAT-HT) were hyp

293 in juvenile mice, but increased survival in adult mice with sepsis.

294 s should be explored.IMPORTANCE Infection of adult mice with the clone 13 (CL13) strain of lymphocyti

295 Importantly, treatment of adult mice with the established disease also reduced ICH

296 In adult mice with toxin (cuprizone)-induced demyelination,

297 wing transplantation into the hippocampus of adult mice with traumatic brain injury, functionally int

298 ring early postnatal neurodevelopment and in adult mice, with implications for our understanding of h

299 tivity via inducible knockout in juvenile or adult mice would result in decreased atRA clearance and

300 Rescue of NMDARs in adult mice yields surprisingly robust improvements in co