ライフサイエンスコーパス: adult neurogenesis

1 es of the CNS and play a fundamental role in adult neurogenesis.

2 ivo expression of active RIT1 driving robust adult neurogenesis.

3 actory acuity, memory, and restored impaired adult neurogenesis.

4 -TGF-beta2/3-Smad2 pathway in the control of adult neurogenesis.

5 y surrounding the functional implications of adult neurogenesis.

6 we report biological functions for miR-19 in adult neurogenesis.

7 important functions in learning, memory, and adult neurogenesis.

8 at extent can lost neurons be replenished by adult neurogenesis.

9 ic marker 5-bromo-2'-deoxyuridine to analyze adult neurogenesis.

10 beling will contribute to expand research on adult neurogenesis.

11 greatly accelerate in vivo investigations of adult neurogenesis.

12 ny in the adult brain, and thereby increases adult neurogenesis.

13 or investigating the behavioral functions of adult neurogenesis.

14 chanism of transcriptional dosage control in adult neurogenesis.

15 at the immune system is a key contributor to adult neurogenesis.

16 each species analyzed when used to quantify adult neurogenesis.

17 and the epigenetic mechanisms that maintain adult neurogenesis.

18 vity-dependent regulation of early events in adult neurogenesis.

19 rinus canaria), a species well-known for its adult neurogenesis.

20 cRNA)--plays a pivotal role in embryonic and adult neurogenesis.

21 n whether they are similarly involved during adult neurogenesis.

22 ew neurons every day, through the process of adult neurogenesis.

23 and glia during persistent or injury-induced adult neurogenesis.

24 g plays a critical role in developmental and adult neurogenesis.

25 rt of BDNF, a crucial factor for hippocampal adult neurogenesis.

26 aling mechanism underlying prolactin-induced adult neurogenesis.

27 tly identify lncRNAs with potential roles in adult neurogenesis.

28 memory, hippocampal synaptic plasticity, and adult neurogenesis.

29 one of the most important brain regions for adult neurogenesis.

30 e dentate gyrus, and suffer from deficits in adult neurogenesis.

31 fferentiate into neurons in a process called adult neurogenesis.

32 point to this pathway as a key regulator of adult neurogenesis.

33 ugs, including antidepressants, can modulate adult neurogenesis.

34 TNF-alpha negatively regulates embryonic and adult neurogenesis.

35 cell-intrinsic molecular pathway regulating adult neurogenesis.

36 l RNA analyses that reveal the complexity of adult neurogenesis.

37 ological disorders and a potent modulator of adult neurogenesis.

38 kout mice is sufficient to prevent defective adult neurogenesis.

39 for tec-1 as negative regulator of planarian adult neurogenesis.

40 ing and retrieval of new information through adult neurogenesis.

41 as become an important focus in the study of adult neurogenesis.

42 ndicate that IH perturbs multiple aspects of adult neurogenesis.

43 ibing a particularly clean way to manipulate adult neurogenesis.

44 and how it should be applied to the study of adult neurogenesis.

45 genitor cell division, in a process known as adult neurogenesis.

46 ppocampal long-term potentiation and reduces adult neurogenesis.

47 as excellent animal models for the study of adult neurogenesis.

48 projections and the intra-bulbar network via adult neurogenesis.

49 ion in vivo during embryonic development and adult neurogenesis.

50 ial phenotype for the investigation of human adult neurogenesis.

51 ly regulating critical genes in aNSCs during adult neurogenesis.

52 dy was to elucidate the function of FXR1P in adult neurogenesis.

53 e important in large mammals with respect to adult neurogenesis.

54 How plastic is adult neurogenesis?

55 Adult neurogenesis, a developmental process of generatin

56 set the stage for a better understanding of adult neurogenesis, a process that one day may inspire n

57 Adult neurogenesis, a specific form of brain plasticity

58 , and justify the comparative examination of adult neurogenesis across mammalian species.

59 In these regions, adult neurogenesis adds another dimension of plasticity

60 The role of microRNAs (miRNAs) in mediating adult neurogenesis after stroke has not been extensively

61 gs show, for the first time, that inhibiting adult neurogenesis alters the circuitry of projection ne

62 ion, we found microglomeruli-like complexes, adult neurogenesis, aminergic innervation, and elevated

63 ve and social behaviors, sleep function, and adult neurogenesis, among many fundamental themes.

64 ess-evoked serotonin release, stimulation of adult neurogenesis and behavioral improvement.

65 mice transferred the effects of exercise on adult neurogenesis and cognition to sedentary aged mice.

66 othesis that the miR-17-92 cluster regulates adult neurogenesis and cognitive function in vivo.

67 At present, the links between adult neurogenesis and depression seem stronger than tho

68 the antidepressant fluoxetine restores both adult neurogenesis and depressive states, and improves m

69 study, we investigated the role of Norbin in adult neurogenesis and depressive-like behaviors using N

70 y reveals the molecular continuum underlying adult neurogenesis and illustrates how Waterfall can be

71 he tumor suppressor gene Pten is involved in adult neurogenesis and is mutated in a subset of autism

72 own syndrome mouse model effectively rescued adult neurogenesis and learning and memory deficits.

73 cial implications for the brain functions of adult neurogenesis and long-term memory.

74 , findings that advance our understanding of adult neurogenesis and may have future regenerative medi

75 em cell aging and impacts the homeostasis of adult neurogenesis and mood regulation.

76 iscovery five decades ago, investigations of adult neurogenesis and neural stem cells have led to an

77 We find that adult neurogenesis and neuronal migration are not unusua

78 work controlling neuronal differentiation in adult neurogenesis and neuronal reprogramming of somatic

79 RK5 as a novel signaling molecule regulating adult neurogenesis and provide strong evidence that adul

80 al upstream role in epigenetic regulation of adult neurogenesis and provides insights into potential

81 theory that depression results from impaired adult neurogenesis and restoration of adult neurogenesis

82 vestigate the relationship between decreased adult neurogenesis and stress-induced changes in hippoca

83 AR from the mouse brain triggers deficits in adult neurogenesis and synapse homeostasis that lead to

84 on also prompted the recovery of hippocampal adult neurogenesis and synaptic plasticity and restored

85 xamined the impact of 30 d of IH (IH(30)) on adult neurogenesis and synaptic plasticity in the dentat

86 active oxygen species-independent effects on adult neurogenesis and synaptic plasticity in the dentat

87 stigated how alpha-synuclein levels modulate adult neurogenesis and the development of dendritic arbo

88 the transcriptional control of neurogenesis, adult neurogenesis and the epigenetic regulation of gene

89 owever, the link between the role of PTEN in adult neurogenesis and the etiology of autism has not be

90 nto how epigenetic regulation contributes to adult neurogenesis and the potential impact of its dysre

91 TEMENT Understanding normal cell kinetics of adult neurogenesis and the type of cells affected by a p

92 addition, we propose unique roles for DCL in adult neurogenesis and we suggest high levels of neurona

93 eptic seizures potently modulate hippocampal adult neurogenesis, and adult-born dentate granule cells

94 ulating neuron number in development, during adult neurogenesis, and following stem cell therapies.

95 ptor signaling in type B stem cells inhibits adult neurogenesis, and further suggest that the regulat

96 Changes in behavioral phenotype, hippocampal adult neurogenesis, and gene expression were evaluated i

97 in the hippocampus could be used to augment adult neurogenesis, and may therefore represent a novel

98 vidence that CX3CL1 is a strong activator of adult neurogenesis, and that it reduces neuronal loss an

99 ptor (OR) expression, synaptic organization, adult neurogenesis, and the contribution of cortical rep

100 and CD44 play important roles in regulating adult neurogenesis, and we provide evidence that HA cont

101 a hippocampal fissure; 2) nonperiventricular adult neurogenesis; and 3) prolonged ontogeny, involving

102 ain has been overturned; however, endogenous adult neurogenesis appears to be insufficient for brain

103 ling mechanisms underlying prolactin-induced adult neurogenesis are completely unknown.

104 cific metabolic programs and their impact on adult neurogenesis are largely unknown.

105 Negative regulators of adult neurogenesis are of particular interest as targets

106 Postnatal and adult neurogenesis are region- and modality-specific, bu

107 Moreover, mice with boosted adult neurogenesis are significantly better at discrimin

108 ursor cell (NPC) survival, and thus maintain adult neurogenesis, are not well defined.

109 pocampal plasticity and memory and implicate adult neurogenesis as a promising therapeutic target to

110 rus provide activity-dependent regulation of adult neurogenesis as well as maintain inhibitory contro

111 ss parallels to recent findings on mammalian adult neurogenesis, as both systems seem to exhibit a si

112 Adult neurogenesis at the ventricle has been most extens

113 t to capture rare dynamic processes, such as adult neurogenesis, because isolation of rare neurons fr

114 Remarkably, the effect of ablating adult neurogenesis before acute seizures is long lasting

115 Here we show that the ablation of adult neurogenesis before pilocarpine-induced acute seiz

116 family cytokines are important regulators of adult neurogenesis, but their involvement in the regulat

117 nal telomeres are required for embryonic and adult neurogenesis, but their uncapping has surprisingly

118 the hippocampal subgranular zone-the site of adult neurogenesis--but was restricted to maturing, rath

119 Accordingly, hunger and satiety regulate adult neurogenesis by modulating the activity of this hy

120 This suppression of adult neurogenesis by the carbon monoxide poisoning was

121 Understanding the circadian regulation of adult neurogenesis can help optimize the timing of thera

122 Here, we review studies of postnatal and adult neurogenesis, challenging the notion that fixed ge

123 action may result in less or no reduction in adult neurogenesis compared with classic opiates.

124 The restoration of adult neurogenesis completely rescued the synaptic plast

125 Adult neurogenesis continually produces a small populati

126 How does adult neurogenesis contribute to memory?

127 as been made in recent years to decipher how adult neurogenesis contributes to brain functions.

128 In the present review, we evaluate how adult neurogenesis contributes to the repair and regener

129 uding the hippocampus, where it might impair adult neurogenesis, contributing to nonmotor symptoms.

130 ession was high in brain areas implicated in adult neurogenesis, DCX-expressing neurons were also abu

131 out (KO) mouse model exhibits behavioral and adult neurogenesis deficits consistent with human illnes

132 hether these correlations reflect changes in adult neurogenesis, detail the conceptual and technical

133 Combining stress and inhibition of adult neurogenesis did not have additive effects on the

134 support a direct role for the importance of adult neurogenesis during abstinence in compulsive-like

135 isruption of ERK signaling, or inhibition of adult neurogenesis, each blocks the ketamine-induced beh

136 Neural activity enhances adult neurogenesis, enabling experience to influence the

137 In contrast, complete inhibition of adult neurogenesis for 4 weeks led to volume reduction o

138 ion, including the possibility of harnessing adult neurogenesis for brain repair.

139 to validate in vivo neuroimaging measures of adult neurogenesis for future investigations.

140 ss possible future directions for harnessing adult neurogenesis for therapeutic use.

141 his local niche, regulate multiple stages of adult neurogenesis, from neural progenitor proliferation

142 ent with a function of TGF-beta signaling in adult neurogenesis, genetic deletion of the TGF-beta rec

143 rited by the offspring, along with increased adult neurogenesis, greater mitochondrial citrate syntha

144 Although adult neurogenesis has been conserved in higher vertebra

145 Whereas adult neurogenesis has been extensively studied in the d

146 D2R) in the deleterious effect of cocaine on adult neurogenesis has not been described yet.

147 can impair this process, and alterations in adult neurogenesis have been described in human autopsy

148 Alterations in adult neurogenesis have been noted in the brain of HIV-i

149 rpoises), in which DG size, convolution, and adult neurogenesis have undergone evolutionary regressio

150 ntial functions conferred by this process of adult neurogenesis, however, remain obscure, despite a s

151 lays important epigenetic roles in mammalian adult neurogenesis; however, the precise molecular mecha

152 wever, it remains unknown whether increasing adult neurogenesis improves hippocampal plasticity and b

153 rotein as a popular indirect tool to monitor adult neurogenesis in a variety of species.

154 nous alpha-synuclein, and we found increased adult neurogenesis in alpha/beta-synuclein knock-out mic

155 adult brain, secretes signals that regulate adult neurogenesis in an age-dependent manner.

156 ude that dogs are a valuable animal model of adult neurogenesis in comparative and preclinical studie

157 Restoring adult neurogenesis in disrupted rats using oxytocin and

158 e, we investigated its role in postnatal and adult neurogenesis in GD3-synthase knock-out (GD3S-KO) a

159 Research focusing on plasticity has shown adult neurogenesis in hippocampal subfields.

160 these neural lineages has become a model of adult neurogenesis in invertebrates.

161 we are able to detect and measure levels of adult neurogenesis in living human brains-a formidable c

162 Notably, OSNs are continually replenished by adult neurogenesis in mammals, including humans, so OSN

163 Although an influence of adult neurogenesis in mediating some of the effects of a

164 t the importance of studying the features of adult neurogenesis in models other than rodents, especia

165 behavioral alterations and rescued abnormal adult neurogenesis in mutant DISC1 mice.

166 mber of new neurons by limited inhibition of adult neurogenesis in naive transgenic GFAP-thymidine ki

167 evertheless, many questions remain regarding adult neurogenesis in other brain regions and particular

168 d others have recently reported constitutive adult neurogenesis in other brain structures, including

169 s for alpha-synuclein-mediated disruption of adult neurogenesis in Parkinson disease.

170 set of transcription factors known to govern adult neurogenesis in response to active RIT1 expression

171 ular mechanisms underlying developmental and adult neurogenesis in rodents and primates.

172 Adult neurogenesis in rodents is modulated by dopaminerg

173 hy of CA3 pyramidal cells and suppression of adult neurogenesis in rodents.

174 es questions about the role of sprouting and adult neurogenesis in sustaining seizure-like activity.

175 hese findings are the first to indicate that adult neurogenesis in the baboon hippocampal DG may be f

176 g their activity, required for understanding adult neurogenesis in the context of network remodeling,

177 Adult neurogenesis in the dentate gyrus (DG) is strongly

178 As both astrocytes and DISC1 influence adult neurogenesis in the dentate gyrus (DG) of the hipp

179 fluoxetine (FLX) on behavior, olfaction, and adult neurogenesis in the dentate gyrus (DG), olfactory

180 It is hypothesized that adult neurogenesis in the dentate gyrus is an ongoing pr

181 Adult neurogenesis in the dentate gyrus of the hippocamp

182 (HDACi) AR-42, ameliorates the deficiency of adult neurogenesis in the granule cell layer of the dent

183 of the Wnt/beta-catenin pathway and restored adult neurogenesis in the hippocampal dentate gyrus (DG)

184 roposes that MDD is linked to impairments of adult neurogenesis in the hippocampal dentate gyrus (DG)

185 tem cells that form the reservoir supporting adult neurogenesis in the hippocampal dentate gyrus and

186 Stroke robustly stimulates adult neurogenesis in the hippocampal dentate gyrus.

187 Adult neurogenesis in the hippocampal subgranular zone (

188 Impairment of adult neurogenesis in the hippocampus causes cognitive d

189 Adult neurogenesis in the hippocampus may represent a fo

190 Adult neurogenesis in the hippocampus subgranular zone i

191 ies have investigated the cellular origin of adult neurogenesis in the hippocampus, yielding divergen

192 tentially adaptive way, possibly by reducing adult neurogenesis in the hippocampus.

193 that impairs synaptic plasticity and reduces adult neurogenesis in the hippocampus.

194 ry of working memory capacity via suboptimal adult neurogenesis in the hippocampus.

195 Here, we show that inhibition of adult neurogenesis in the mouse dentate gyrus decreases

196 Adult neurogenesis in the olfactory bulb (OB) is conside

197 Adult neurogenesis in the olfactory epithelium is often

198 recent progress on the molecular control of adult neurogenesis in the SGZ and SVZ, focusing on the r

199 tor (BDNF) has been implicated in regulating adult neurogenesis in the subgranular zone (SGZ) of the

200 the importance of Igf2 imprinting for murine adult neurogenesis in the subventricular zone (SVZ) and

201 Prolactin-stimulated adult neurogenesis in the subventricular zone (SVZ) and

202 of new neurons added to HVC, suggesting that adult neurogenesis in this context may contribute to beh

203 ey role in the correct development of DG and adult neurogenesis in this region.

204 rmacogenetic methods to conditionally ablate adult neurogenesis in transgenic mice, we find that the

205 and the harmine metabolite harmol, stimulate adult neurogenesis in vitro.

206 owerful model to identify genes required for adult neurogenesis in vivo.

207 n of neuronal differentiation and attenuates adult neurogenesis in vivo.

208 junction with behavioral tests, we evaluated adult neurogenesis, including neural progenitor prolifer

209 ious interpretation of these results is that adult neurogenesis indirectly regulates hippocampal info

210 Adult neurogenesis is a key feature of the mammalian olf

211 Adult neurogenesis is actively studied in part because o

212 achinery is present in adult rats, even when adult neurogenesis is blocked.

213 eurogenesis and provide strong evidence that adult neurogenesis is critical for several forms of hipp

214 Early studies found that adult neurogenesis is impaired in models of depression a

215 Adult neurogenesis is involved in cognitive performance

216 Taken together, our results suggest that adult neurogenesis is involved in the delayed long-lasti

217 e of epigenetic regulators in the control of adult neurogenesis is largely undefined.

218 , the relationship between these factors and adult neurogenesis is less well understood.

219 Adult neurogenesis is maintained by self-renewable neura

220 Adult neurogenesis is modulated by a balance of extrinsi

221 osis of the apoptotic cells generated during adult neurogenesis is normally driven by both TAM recept

222 y considering a general model proposing that adult neurogenesis is not a cell-replacement mechanism,

223 ammalian brain with respect to embryonic and adult neurogenesis is poorly understood.

224 The findings suggest that adult neurogenesis is required to maintain hippocampal v

225 d behavior; however, we find that increasing adult neurogenesis is sufficient to reduce anxiety and d

226 A major question in studying adult neurogenesis is the source and identity of molecul

227 Adult neurogenesis is thought to provide neural plastici

228 This new vertebrate model of adult neurogenesis is thus advancing our knowledge of th

229 , but how alpha-syn and its mutations affect adult neurogenesis is unclear.

230 brain, the potential role of TET proteins in adult neurogenesis is unknown.

231 This process, named adult neurogenesis, is involved in important cognitive f

232 ocampal dentate gyrus, a region with ongoing adult neurogenesis, is sensitive to MAGUK loss in mature

233 paired adult neurogenesis and restoration of adult neurogenesis leads to recovery.

234 edictable restraint stress and inhibition of adult neurogenesis led to atrophy of pyramidal cell apic

235 lular mechanisms and functional relevance of adult neurogenesis, many studies rely on quantification

236 tion of bromodeoxyuridine and two additional adult neurogenesis markers, Ki-67 and doublecortin, in t

237 udy, consistent with the interpretation that adult neurogenesis may be associated with selective form

238 Although there is evidence suggesting that adult neurogenesis may contribute to hippocampus-depende

239 Thus, during adult neurogenesis, microglia regulate the elimination (

240 To examine whether adult neurogenesis might contribute to regeneration afte

241 mune and inflammatory markers (N = 118), and adult neurogenesis (N = 6).

242 o neuronal plasticity, and induce changes in adult neurogenesis, neuritic maintenance, synaptic trans

243 During embryonic and adult neurogenesis, neuronal stem cells follow a highly

244 We propose that adult neurogenesis not only replenishes the population o

245 Adult neurogenesis occurs in the dentate gyrus of the hi

246 Adult neurogenesis occurs in the dentate gyrus of the hi

247 Hippocampus is a brain region where adult neurogenesis occurs with functional implications i

248 hippocampus, one of the brain regions where adult neurogenesis occurs, in development of autism is n

249 nance and proliferation during postnatal and adult neurogenesis of the subgranular zone.

250 al circuitry for understanding the impact of adult neurogenesis on brain function.

251 However, their potential roles in adult neurogenesis or central nervous system (CNS) funct

252 Adult neurogenesis persists in the rodent dentate gyrus

253 Adult neurogenesis persists throughout life in restricte

254 Thus, adult neurogenesis plays a central role in the adaptive

255 Adult neurogenesis plays an important role in brain func

256 spatial learning and memory, suggesting that adult neurogenesis plays an important role in hippocampu

257 We investigated the role that adult neurogenesis plays in the seasonal reconstruction

258 We investigated the role that adult neurogenesis plays in the seasonal reconstruction

259 These results suggest that adult neurogenesis produces a population of functionally

260 Inhibition of adult neurogenesis produces some behavioral impairments

261 ioration of beta amyloid load or hippocampal adult neurogenesis rate but were accompanied by a dramat

262 Before training, X-ray ablation of adult neurogenesis-reduced dentate responses to perforan

263 endent regulation of the sequential steps of adult neurogenesis remains largely unknown.

264 l consequence of sleep apnea, on hippocampal adult neurogenesis remains unclear.

265 Wnt/Planar cell polarity (PCP) signaling in adult neurogenesis remains unknown.

266 Adult neurogenesis represents a unique form of plasticit

267 A central goal of adult neurogenesis research is to characterize the cellu

268 on, olfactory deafferentation did not reduce adult neurogenesis, showing that activated microglial ce

269 e IL-6 receptor (IL-6R) and robustly support adult neurogenesis, specifically by augmenting the survi

270 Adult neurogenesis supports performance in many hippocam

271 Adult neurogenesis, the formation of new neurons in the

272 Among the multiple steps of adult neurogenesis, the integration and survival of adul

273 ral changes span from synaptic plasticity to adult neurogenesis, the latter being highly reduced in l

274 Adult neurogenesis, the process of generating mature neu

275 Adult neurogenesis, the process of generating mature neu

276 Several lines of evidence suggest that adult neurogenesis, the production of new neurons in adu

277 APP controls adult neurogenesis through a non cell-autonomous mechani

278 ol of an imprinted gene in the regulation of adult neurogenesis through an unconventional role of TET

279 ack-signal likely enhances developmental and adult neurogenesis through the TGFbeta2/3-Smad2/3 pathwa

280 The contribution of adult neurogenesis to memory is indirect, by regulating

281 This article reviews the data relating adult neurogenesis to mental illness and discusses where

282 of the SVZ, we highlighted the importance of adult neurogenesis to specifically improve performance i

283 ts short lifespan and shows the high rate of adult neurogenesis typical of anamniotes.

284 rowth across the life span, we estimate that adult neurogenesis ultimately produces half of the cells

285 tify a role of Agrin-Lrp4-Ror2 signaling for adult neurogenesis, uncovering previously unexpected fun

286 cute carbon monoxide poisoning by preserving adult neurogenesis via an increase in hippocampal brain-

287 The circadian system may regulate adult neurogenesis via intracellular molecular clock mec

288 sting activity-dependent mechanism governing adult neurogenesis via the acute release of tonic inhibi

289 Adult neurogenesis was initially studied with the tritia

290 Intriguingly, the enhanced adult neurogenesis was mitigated when Smad2 expression w

291 sensitivity to hypoxia/anoxia, and decreased adult neurogenesis was observed in the dentate gyrus.

292 tant DISC1-associated behaviors and abnormal adult neurogenesis were also examined.

293 These deficits in adult neurogenesis were rescued with administration of p

294 And, conversely, studies in animals lacking adult neurogenesis, which are likely to have more limite

295 uppressed, respectively, unlike mice lacking adult neurogenesis, which did not change.

296 the life span of PS19 tau mice by enhancing adult neurogenesis while having minimal effect on tau pa

297 We show that BLA lesions suppress adult neurogenesis, while lesions of the central nucleus

298 ing covered diverse aspects of embryonic and adult neurogenesis with a focus on novel technologies, i

299 otion raised an interesting question whether adult neurogenesis within specific subregions of the hip

300 In adult neurogenesis young neurons connect to the existing