ライフサイエンスコーパス: adult offspring

1 d with cardiometabolic risk factors in young adult offspring.

2 se persisting abnormalities (programming) in adult offspring.

3 ain responses to the fear conditioned cue in adult offspring.

4 increases the risk for schizophrenia in the adult offspring.

5 ophysiological consequences in the hearts of adult offspring.

6 ents of hepatic and muscle Akt expression in adult offspring.

7 o PKCepsilon gene repression in the heart of adult offspring.

8 genotyped these two SNPs in 1679 CLHNS young adult offspring.

9 ssociated with a more atherogenic profile in adult offspring.

10 e contributes to the development of NAFLD in adult offspring.

11 rain and subsequent cognitive impairments in adult offspring.

12 d maternal undernutrition to the size of the adult offspring.

13 changes in gene expression in the brains of adult offspring.

14 opiate exposure blunts the fever response of adult offspring.

15 ened cardiovascular response to restraint in adult offspring.

16 ) and latent inhibition (LI) deficits in the adult offspring.

17 erability of ischemic injury in the heart of adult offspring.

18 mesenteric artery endothelial dysfunction in adult offspring.

19 -term effects on cardiovascular responses in adult offspring.

20 rmanently enhances memory performance of the adult offspring.

21 increased risk of nicotine dependence among adult offspring.

22 me of birth and risk of schizophrenia in the adult offspring.

23 their spouses (parents' generation) or their adult offspring.

24 demonstrate that MIA induced NOR deficits in adult offspring.

25 10%) by prenatal exposure to cocaine only in adult offspring.

26 cular dysfunction in rat weanlings and young adult offspring.

27 birth weight and causes hyperglycemia in the adult offspring.

28 re pronounced worsening in the health of the adult offspring.

29 e levels during the acute stress response in adult offspring.

30 r for neurodevelopmental disorders (NDDs) in adult offspring.

31 and replenishing endothelial function in the adult offspring.

32 of metabolic diseases and atherosclerosis in adult offspring.

33 ation and a range of neuropathologies in the adult offspring.

34 ty, as well as impairs glucose metabolism in adult offspring.

35 omote the development of coronary disease in adult offspring.

36 ts in the past year experienced by the young adult offspring.

37 risk of developing cardiovascular disease in adult offspring.

38 ls, delayed meiosis and reduced fecundity in adult offspring.

39 etabolism of carbohydrates and lipids in the adult offspring.

40 eft ventricular diastolic dysfunction in the adult offspring.

41 ing (IS) in the gastrocnemius muscle (GM) of adult offspring.

42 n hippocampal atrophy and memory loss in the adult offspring.

43 onal- or dopamine-associated marker genes in adult offspring.

44 enatal retina, as well as visual function in adult offspring.

45 increase in gut butyrate in the juvenile and adult offspring.

46 of Mfsd12 knockout embryos, yielding viable adult offspring.

47 evelopmental memories of the mother by their adult offspring.

48 ay therefore impact cancer susceptibility in adult offspring.

49 stress, and increased cardiovascular risk in adult offspring.

50 gnificantly impairing memory function in the adult offspring.

51 and fetal offspring, and social behavior in adult offspring.

52 in both medial and basolateral subregions in adult offspring.

53 and decreased GLUT4 expression in the GM of adult offspring.

54 els, and alterations in insulin signaling in adult offspring.

55 and increased cardiovascular disease in the adult offspring.

56 attenuates the adverse metabolic outcomes in adult offspring.

57 iation has rarely been investigated in young adult offspring.

58 panied by schizophrenia-like behavior in the adult offspring.

59 hippocampal Dio3 and Igf2 expressions in the adult offspring.

60 ning and by a shortage of follow-up data for adult offspring.

61 nd its relation to testicular dysfunction in adult offspring.

62 l thickness were measured in male and female adult offspring.

63 ne environment alters vascular reactivity in adult offspring.

64 uses hypertension and cardiac hypertrophy in adult offspring.

65 ring pregnancy leads to metabolic changes in adult offspring.

66 ing diabetes, obesity and premature death in adult offspring.

67 fetal programming of vascular reactivity in adult offspring.

68 ring pregnancy promotes physical activity in adult offspring.

69 ight, and obesity and premature mortality in adult offspring.

70 rations in the fine motor performance of the adult offspring.

71 nd the efficiency of immune responses in the adult offspring.

72 otypes but to a greater extent in the Ts65Dn adult offspring.

73 ession and improves glucose tolerance in the adult offspring.

74 e rats and in the brain of their neonate and adult offspring.

75 f selected BER-related genes in the brain of adult offspring.

76 ow heat tolerance increased the tolerance of adult offspring (3-4-year-olds).

77 (2.5, 5, and 10 mg/kg i.p.) was assessed in adult offspring (70-90 days of age) using a rate-frequen

78 The study examined 197 adult offspring (95 male and 102 female) of alcoholic bi

79 5-HT(2A) receptor (5-HT(2A)R) density in the adult offspring, a phenotype previously observed in post

80 tional weight gain (GWG) are associated with adult offspring adiposity.

81 ific transgenerational parent age effects on adult offspring age-specific life-history traits to full

82 We included 6347 adult offspring (age, 18-52 years) investigated in the R

83 Young adult offspring (age, 21 years [N = 433]) provided self-

84 3 to 84 years in 1987 through 1988 and their adult offspring aged 21 to 84 years in 2005 through 2008

85 middle-aged women and their female and male adult offspring (aged 18-23 y) and to examine the associ

86 is "interneuronopathy" persists in the young adult offspring and contributes to enduring changes in (

87 affects brain structure and function in the adult offspring and explored underlying mechanisms with

88 tyrate and brain lactate in the juvenile and adult offspring and increased the expression of prefront

89 iatal DAT availability that were apparent in adult offspring and were associated with behavioral char

90 sex-dependent executive function deficits in adult offspring, and sexually divergent shifts in microg

91 latively leading to long-term improvement in adult offspring; and (ii) maternal behavior can attenuat

92 f MgSO4 in clinical practice, its effects on adult offspring are not well known nor have sex-specific

93 ding were observed in the dorsal striatum of adult offspring as a consequence of germline THC exposur

94 ing of Holocaust survivors, thus identifying adult offspring as a possible high-risk group within whi

95 ve (dopaminergic) neurons in the midbrain of adult offspring as compared to age-matched, control-diet

96 Parental prebirth, parental concurrent, and adult offspring assessments occurred in 1971-1983, 1998-

97 and p38 MAPK activity in left ventricular of adult offspring at resting state.

98 xamine the effects on gene expression within adult offspring at ~6 and 11 mo of age.

99 consequences of maternal e-cigarette use on adult offspring behavior and neuroimmune outcomes.

100 d that the development of atherosclerosis in adult offspring born to diabetic pregnancy can be in par

101 Adult offspring (both Ts65Dn and 2N) of choline-suppleme

102 caused low birth-weight and changes in young adult offspring brain, mimicking those in human neuropsy

103 induce insulin resistance and reduce IST in adult offspring, but such alterations are not attributab

104 impair the vascular health of adolescent and adult offspring, but the critical gestation window for E

105 ovascular and metabolic dysfunction in their adult offspring, but the intrauterine mechanisms involve

106 cient mice indeed reduced atherosclerosis in adult offspring by up to 56%, but the protective effect

107 of parental age with a suite of outcomes in adult offspring, comparing the results from an array of

108 Subjects were adult offspring derived from a 2 x 2 experiment in which

109 Subsequent genotyping of CLHNS young adult offspring detected an uncommon variant [minor alle

110 dy examined associations between parents and adult offspring diagnoses of the MS and its risk factors

111 Mother-adult offspring dietary resemblance in this Australian c

112 e induced in the hippocampus of neonatal and adult offspring due to maternal and progeny HFD, but rec

113 Adult offspring dyslipidemia is associated with maternal

114 atal cohort, we tested this hypothesis in 80 adult offspring, equally divided by sex, followed from i

115 nique prenatal cohort, we tested this in 204 adult offspring, equally divided by sex, who were expose

116 ke is limited during pregnancy, we show that adult offspring exhibit cognitive and anxiety-like behav

117 In young adult offspring exposed to ethanol in utero, this effect

118 a greater risk of cardiometabolic disease in adult offspring exposed to maternal obesity are not know

119 Furthermore, young adult offspring exposed to the 3 day binge-type ethanol

120 that paternal HFD significantly altered the adult offspring Firmicutes to Bacteroidetes ratio, an in

121 ioral and neuroimmunological consequences to adult offspring following maternal e-cigarette exposure

122 Analyses in the AA adolescent/young adult (offspring from COGA families) subsample indicated

123 Adult offspring from all parental exercise groups had si

124 gitudinal subsample of 2316 adolescent/young adult offspring from COGA families (ages 12-30) and exam

125 Adult offspring from dams colonized with an aged microbi

126 y-related deficits in cortex and striatum in adult offspring from MIA.

127 ehavior induced community-wide shifts to the adult offspring gut microbiome.

128 Kidneys of the adult offspring had few structural or functional abnorma

129 Remarkably, Pl-OGT adult offspring had reduced body weights and elevated hy

130 MIA-induced deficits in adolescent and adult offspring have been well characterized; however, l

131 Although the impact of maternal diet on adult offspring health is well characterized, the role t

132 at diabetes in pregnancy, but the effects on adult offspring health remain under-explored.

133 postnatal life has substantial influence on adult offspring health.

134 mpus, with effects on memory that persist in adult offspring; higher choline intake is associated wit

135 aled alterations in the transcriptome of the adult offspring hippocampus, hypothalamus and amygdala,

136 At the time of testing of adult offspring, hormone status had returned to control

137 In hearts of both fetuses and adult offspring, hypoxia-induced methylation of SP1 site

138 , offspring viability) and higher numbers of adult offspring (i.e., productivity) than MOC females, s

139 bility to ischemia and reperfusion injury in adult offspring in rats.

140 of maternal cholestasis on the metabolism of adult offspring in the mouse.

141 Our previous brain imaging findings in adult offspring in these high-risk families also reveale

142 Adverse impacts in adult offspring include impairment of cardiovascular fun

143 y and can programme cardiac abnormalities in adult offspring including ventricular remodelling, diast

144 rs lost from cardiovascular disease (CVD) in adult offspring is unknown.

145 nal exercise improve the metabolic health of adult offspring is well established.

146 d with reduced Na(+),K(+)-ATPase activity in adult offspring kidney.

147 ntral renin-angiotensin system regulators in adult offspring kidneys.

148 L-C levels explained 13% of the variation in adult offspring LDL-C levels beyond common genetic varia

149 Adult offspring LDL-C levels were associated with matern

150 Adult offspring LDL-C levels were examined as both a con

151 concurrent LDL-C levels in association with adult offspring LDL-C levels.

152 ulatory responses in the hearts of fetal and adult offspring link molecular mechanisms to the protect

153 ot show any gross metabolic disruptions, the adult offspring maintain hematopoietic features associat

154 ity to ischaemia-reperfusion (I/R) injury in adult offspring male and female rats.

155 sociations between maternal prenatal BMI and adult offspring mental disorders may carry important pub

156 ternal obesity or underweight associate with adult offspring mental disorders.

157 d sites in H9c2 cells, hearts of fetuses and adult offspring, methylation of both SP1 sites reduced S

158 vioral and cognitive characterization of the adult offspring (n = 12 per group), unbiased capture arr

159 sured in Holocaust survivors (n = 32), their adult offspring (n = 22), and demographically comparable

160 Adult offspring (n = 38) were imaged by positron emissio

161 allelic expression of Dio3 in the fetal and adult offspring of alcohol-consuming and control dams, w

162 Adult offspring of both sexes exposed to + Nic exhibited

163 We assessed, in adult offspring of both sexes, performance on a battery

164 ces cardiovascular and metabolic function in adult offspring of C57BL/6J mice in comparison with anim

165 Specifically, the adult offspring of choline-supplemented Ts65Dn dams perf

166 Participants were 114 adult offspring of depressed and nondepressed parents, f

167 major depression, assessed prospectively, in adult offspring of depressed probands who reported that

168 d long-lasting behavioral alterations in the adult offspring of either sex, with an impairment of soc

169 sistent changes were determined in F1 and F2 adult offspring of F0 mothers exposed to two relevant hu

170 aptive" responses in a rodent model in which adult offspring of fat-fed dams develop characteristics

171 l mGluR1-induced long-term depression in the adult offspring of high-LG compared with low-LG mothers,

172 imethylation of Grm1 in hippocampus from the adult offspring of high-LG compared with low-LG mothers.

173 nd other psychiatric diagnoses in a group of adult offspring of Holocaust survivors (N=100) and a dem

174 rinary cortisol excretion was measured in 35 adult offspring of Holocaust survivors and 15 healthy co

175 The data show that although adult offspring of Holocaust survivors did not experienc

176 stress disorder (PTSD) have been observed in adult offspring of Holocaust survivors in both glucocort

177 The authors have reported that adult offspring of Holocaust survivors showed lower meth

178 on cortisol negative feedback inhibition in adult offspring of Holocaust survivors with PTSD (N=13)

179 d thereby improvement in cardiac function in adult offspring of hypoxic pregnancy treated with melato

180 tamin C prevented these effects in fetal and adult offspring of hypoxic pregnancy.

181 tion of programmed cardiovascular disease in adult offspring of hypoxic pregnancy.

182 Adult offspring of immune-challenged mothers displayed h

183 Adult offspring of LP0.5-exposed mothers exhibited gluco

184 We found that 2 weeks of ISO treatment in adult offspring of LPS-treated mothers led to augmented

185 To determine the effects in adult offspring of maternal exposure to stress and alcoh

186 uR1 mRNA and protein in hippocampus from the adult offspring of mothers showing an increased frequenc

187 AR-dependent long-term potentiation (LTP) in adult offspring of mothers that varied in the frequency

188 mere length in young (4 mo) and aged (15 mo) adult offspring of normoxic or hypoxic pregnancy with or

189 Cardiac Pparg expression remained higher in adult offspring of obese dams than control dams and was

190 ormal emotional behavior in the juvenile and adult offspring of obese dams.

191 development increases cardiovascular risk in adult offspring of pregnancies complicated by chronic fe

192 Studying adult offspring of pregnant mice subjected to PRS, we ex

193 itivity (euglycemic clamp) were performed in adult offspring of probands.

194 To examine this, adult offspring of rat dams either fed a control diet (C

195 Perfused livers of 48-h- starved adult offspring of rat dams fed 8% protein diets during

196 In the adult offspring of rats exposed to dexamethasone in late

197 We recently reported vascular dysfunction in adult offspring of rats fed a fat-rich (animal lard) die

198 ed whether abnormal vascular function in the adult offspring of rats fed a high saturated fat diet in

199 Adult offspring of rats that were given sufficient choli

200 This study aimed to evaluate in the adult offspring of rats with periodontal disease: IR, in

201 Adult offspring of RES-treated mothers showed increased

202 ave examined vascular and renal structure in adult offspring of Sprague-Dawley rats fed a control die

203 or spirituality with major depression in the adult offspring of the original sample using a 10-year p

204 BOSS (2005-2008) is a study of aging in the adult offspring of the population-based Epidemiology of

205 Adult offspring of time-pregnant dams that were given a

206 her studies on the health and pregnancies of adult offspring of transplant patients are warranted.

207 We studied 206 adult offspring of women with gestational diabetes melli

208 Participants were 1086 mother-adult offspring pairs (59% female) from the New England

209 At 4 months, tissues from 1 male adult offspring per litter per group were either perfusi

210 Finally, in adult offspring, perinatal B-GOS intake increased cortic

211 ero and suckling periods in establishing the adult offspring phenotype in response to an environmenta

212 ellets on a progressive-ratio (PR) schedule, adult offspring prenatally exposed to cocaine were obser

213 ulated the social behavioral deficits in the adult offspring previously observed in the prenatal rest

214 ion has a profound effect on the behavior of adult offspring, probably via an effect of the maternal

215 In Study 1, adult offspring received BI 409306 0.2, 0.5, or 1 mg/kg

216 In Study 2, adult offspring received BI 409306 1 mg/kg and/or risper

217 al low protein diet modified F1 neonatal and adult offspring renin-angiotensin system activity and ca

218 diet reveals that behavioural impairments in adult offspring require diet-induced conditioning of bot

219 long-lasting deleterious consequences in the adult offspring solely mediated by its ability to disrup

220 nal IL-6 response negatively correlated with adult offspring SST mRNA in cortex and striatum, but not

221 d heart susceptibility to ischemic injury in adult offspring, suggesting an in utero programming of P

222 damage responding to isoproterenol (ISO) in adult offspring that underwent maternal inflammation (mo

223 iation into distinct effector populations in adult offspring that were infected with influenza A viru

224 As adults, offspring that received low perinatal n-6/n-3 ra

225 e showed that the resilience of juvenile and adult offspring to anxiety-like behavior was most promin

226 y, and during 1 h of restraint stress in the adult offspring using indwelling arterial catheters impl

227 perm or seminal fluid at conception impaired adult offspring vascular function in response to both va

228 y for metabolic dysregulation and obesity in adult offspring via epigenetic modifications.

229 cardiomyocyte dysfunction in male and female adult offspring was ameliorated by maternal antenatal tr

230 In adult offspring, we find that this memory is associated

231 Adult offspring were assessed for sensory inhibition.

232 s, striatum and midbrain of prepubescent and adult offspring were determined by measuring: (1) the co

233 Adult offspring were evaluated for effects of placental

234 After foster rearing, adult offspring were exposed to the stressor and trained

235 percent egg-to-adult survival and number of adult offspring were higher for PMC than MMC females, sh

236 A total of 177 HTLV-1-infected women and 369 adult offspring were investigated.

237 s, the behavior, cognition and brains of the adult offspring were studied.

238 icroglial engulfment was assessed at P8, and adult offspring were tested in a behavioral battery to m

239 As adults, offspring were fed either a low-fat diet (LFD) o

240 success (measured as the number of returning adult offspring) when spawned in captivity compared with

241 ession-like behavioral traits to manifest in adult offspring, which is consistent with genetic models

242 contributes toward the NAFLD progression in adult offspring, which is mediated through impaired hepa

243 DNA damage levels in subcortical regions of adult offspring, which may increase sensitivity to oxida

244 sity reduced synaptophysin expression in the adult offspring, while perinatal probiotic exposure incr

245 crobial metabolites during pregnancy yielded adult offspring with altered tactile sensitivity in two

246 Adult offspring with at least one Holocaust survivor par

247 ith hyperglycemia at age 39 years and in two adult offspring with impaired insulin secretion.

248 family functioning when there is a child or adult offspring with intellectual disability.

249 Females homozygous for tuh-1h always produce adult offspring with more bristles than females homozygo

250 des or both, was significantly higher in the adult offspring with parental CAD.

251 to enhance the probability that they produce adult offspring with rarer phenotypes with survival bene