ライフサイエンスコーパス: adult stem cell

1 e existence of a Wnt/beta-catenin-responsive adult stem cell.

2 ce is essential for long-term maintenance of adult stem cells.

3 affects the regenerative potentials of human adult stem cells.

4 the specific effects of p53 loss in colonic adult stem cells.

5 to adults, Lin-28 persists in populations of adult stem cells.

6 f epigenetic gene silencing in embryonic and adult stem cells.

7 ring gastrulation and the differentiation of adult stem cells.

8 nes in induced pluripotent stem cells and in adult stem cells.

9 ing cell cycle progression in populations of adult stem cells.

10 ant, accessible, and replenishable source of adult stem cells.

11 al gene and by promoting genome stability in adult stem cells.

12 control at the H19-Igf2 locus in maintaining adult stem cells.

13 , as well as the self-renewal and fitness of adult stem cells.

14 attractive model for studying regulation of adult stem cells.

15 gets also regulate changes between fetal and adult stem cells.

16 -catenin signaling is a central regulator of adult stem cells.

17 vidence demonstrating this effect in healthy adult stem cells.

18 euronal lineage specification of multipotent adult stem cells.

19 e to validate a novel strategy for selecting adult stem cells.

20 to control differentiation in embryonic and adult stem cells.

21 pathways thought to play important roles in adult stem cells.

22 se regulating the self-renewal capability of adult stem cells.

23 t transcriptional regulator in embryonic and adult stem cells.

24 (CNS) that produces new myelin sheaths from adult stem cells.

25 aden and refine concepts of the phenotype of adult stem cells.

26 eled by a population of highly proliferative adult stem cells.

27 -beta superfamily functions in embryonic and adult stem cells.

28 t and in the self-renewal and maintenance of adult stem cells.

29 and functional properties of tissue specific adult stem cells.

30 idence supporting a role for Hh signaling in adult stem cells.

31 d systems currently available that propagate adult stem cells.

32 bilities, which involve abundant pluripotent adult stem cells.

33 s that line the brain ventricular system and adult stem cells.

34 l differentiation of embryonic stem (ES) and adult stem cells.

35 ulation and fulfilling criteria of unipotent adult stem cells.

36 of newly differentiated cells from resident adult stem cells.

37 neration depends on the timely activation of adult stem cells.

38 scape for myocardial regeneration powered by adult stem cells 4 years ago.(1) The intervening years s

39 Deterioration of adult stem cells accounts for much of aging-associated c

40 Adult stem cells across diverse organs self-renew and di

41 ted of implanting autologous adipose-derived adult stem cells (ADASc) with or without sheets of decel

42 Tissue-resident adult stem cells (AdSCs) also form organoids when grown

43 recent advances in our understanding of why adult stem cells age and how this aging impacts diseases

44 How environmental cues regulate adult stem cell and cancer cell activity through surface

45 regeneration owing to a loss of function of adult stem cell and progenitor cell populations(1).

46 n of comprehensive profiling technologies to adult stem cell and progenitor populations has been chal

47 d and manipulated the cell cycle programs of adult stem cells and enterocytes.

48 We found that CRCs share characteristics of adult stem cells and exhibit up-regulated expression of

49 ceptors in maintenance of stemness of normal adult stem cells and in support of cancer development.

50 Most important, adult stem cells and in vitro-generated myocytes and ost

51 Adhesion between adult stem cells and niche cells or the local basement m

52 yl oxidase that is enriched in embryonic and adult stem cells and plays an essential prosurvival role

53 ies to remuscularize the injured heart using adult stem cells and pluripotent stem cells, cellular re

54 very of crypt base columnar cells as LGR5(+) adult stem cells and summarizes subsequent progress, pro

55 s an important role in lineage commitment of adult stem cells and that it could be used for clinical

56 ates with significant alterations in somatic/adult stem cells and therapies to counteract these might

57 cardiac stem cell regenerative therapy using adult stem cells and to highlight the merits and limitat

58 ll differentiation in embryonic development, adult stem cells, and cancer pathogenesis.

59 nd oxidative stress during the maturation of adult stem cells, and during the reprogramming of somati

60 lf-renewal and pluripotency of embryonic and adult stem cells, and merging 3D printing with bioconjug

61 egenerate their entire CNS using pluripotent adult stem cells, and this process is robustly regulated

62 Adult stem cells are a keystone of tissue homeostasis th

63 Adult stem cells are believed to be maintained by a spec

64 her mature hepatocytes or a subpopulation of adult stem cells are capable of full recovery in severe

65 Tissue-specific adult stem cells are commonly associated with local nich

66 Adult stem cells are crucial for growth, homeostasis and

67 Adult stem cells are defined by their ability to both se

68 Both embryonic and adult stem cells are endowed with a superior capacity to

69 Adult stem cells are essential for tissue homeostasis an

70 Adult stem cells are essential for tissue homeostasis.

71 Previous studies have revealed that adult stem cells are influenced by whole-body physiology

72 Unlike differentiated cells, adult stem cells are intrinsically resistant to senescen

73 Tissue resident adult stem cells are known to participate in tissue rege

74 Adult stem cells are multipotent and persist in small nu

75 er, the master transcriptional regulators of adult stem cells are poorly understood.

76 Adult stem cells are resistant to DNA damage-induced apo

77 function of endogenous Dnmt3a and Dnmt3b in adult stem cells are unknown.

78 pathway plays a fundamental role in multiple adult stem cells, as well as in orchestrating proper mam

79 l accumulation of genetic mutations in human adult stem cells (ASCs) during life is associated with v

80 Under defined growth factor conditions, such adult stem cells (ASCs) grow as 3D organoids that recapi

81 Neoblasts are adult stem cells (ASCs) in planarians that sustain cell

82 are an abundant, heterogeneous population of adult stem cells (ASCs) that facilitate the maintenance

83 tissue homeostasis is generally mediated by adult stem cells (ASCs), tissue-specific stem cells resp

84 meostasis and regeneration due to its unique adult stem cells (ASCs).

85 te the potential of a system for delivery of adult stem cells at any time after primary percutaneous

86 represent an excellent model system to study adult stem cell behavior; however, the earliest stages o

87 The mechanisms underlying adult stem cell behaviour are likely to be diverse and h

88 eleost retina as an ideal model for studying adult stem cell biology at single cell resolution.

89 ertebrates, functioning in embryogenesis and adult stem cell biology.

90 ide an excellent system for in vivo study of adult stem cell biology.

91 s essential for the long-term maintenance of adult stem cells but how stem cells maintain quiescence

92 self-renewal and differentiation of various adult stem cells, but its role in cell fate determinatio

93 ability in cells derived from pluripotent or adult stem cells, but surprisingly, transdifferentiated

94 d segregation correlate with self-renewal of adult stem cells, but the capacity of CPCs for asymmetri

95 rged as important regulators of invertebrate adult stem cells, but their activities remain poorly app

96 f multiple organs as well as the survival of adult stem cells by activation of canonical Wnt signalin

97 cer stem cells are distinguished from normal adult stem cells by their stemness without tissue homeos

98 flatworms are attributed to a population of adult stem cells called neoblasts that proliferate and d

99 racardiac injection of two distinct types of adult stem cells, cells killed by freezing and thawing o

100 How adult stem cells choose and acquire new fates is unknown

101 Adult stem cells commonly give rise to transit-amplifyin

102 Many adult stem cell communities are maintained by population

103 actors, which hence define properties of the adult stem cell compartment.

104 They control embryonic development and adult stem cell compartments, and their dysregulation of

105 ew the importance of chromatin regulation in adult stem cell compartments.

106 e we show, for the first time, that Sox10(+) adult stem cells contribute to both encapsulation and mi

107 The accumulation of somatic mutations in adult stem cells contributes to the decline of tissue fu

108 Here we tested whether the induction of adult stem cells could repair chemoradiation-induced tis

109 Here, we identify adult stem cell deficits that drive ENT3-related abnorma

110 iple compartments for orchestrating stepwise adult stem cell development and has also provided useful

111 levels undergo highly dynamic changes during adult stem cell differentiation from intestinal progenit

112 port high-resolution DNA methylation maps of adult stem cell differentiation in mouse, focusing on 19

113 l-time label-free quantitative monitoring of adult stem cell differentiation with impedance sensing.

114 ified as key regulators of HOX signaling and adult stem cell differentiation.

115 Adult stem cells divide to renew the stem cell pool and

116 mechanism through which Lin-28 controls the adult stem cell division patterns that underlie tissue h

117 l cells that give rise to neurons, glia, and adult stem cells during brain development.

118 ssociated with changes in DNA methylation in adult stem cells during lifetime are still largely unkno

119 ion and/or proliferation of adult intestinal adult stem cells during postembryonic development in ver

120 Exploring adult stem cell dynamics in normal and disease states is

121 Recent advances in adult stem cell enrichment and transplantation, bioengin

122 rd injury and provide specific evidence that adult stem cells exert positive immunomodulatory and neu

123 Many types of adult stem cells exist in a state of cell-cycle quiescen

124 Adult stem cells exist in most mammalian organs and tiss

125 ere length; embryonic stem cells and certain adult stem cells express mTert, but whether cells in the

126 difiers and pioneer transcription factors in adult stem cell fate decisions and plasticity, which ens

127 1alpha and mTOR signalling and regulation of adult stem cell fate.

128 gy opens new possibilities of using cultured adult stem cells for drug development, disease modeling,

129 resting or injured pancreas do not behave as adult stem cells for insulin-producing beta (beta)-cells

130 shed a foundation for basic knowledge on how adult stem cells form, maintain, and repair tissues and

131 igated the autocrine effect of PGE2 on human adult stem cells from cord blood or adipose tissue, and

132 A healthy diet improves adult stem cell function and delays diseases such as can

133 and persistent DNA damage may cause loss of adult stem cell function.

134 emerging as key regulators of embryonic and adult stem cell function.

135 With ageing, there is a loss of adult stem cell function.

136 testing whether Prdm16 is also required for adult stem cell function.

137 polarity complex is unexplored in mammalian adult stem-cell functions.

138 ed R-spondin proteins (RSPOs1-4) function as adult stem cell growth factors by potentiating Wnt signa

139 R-spondin proteins are adult stem cell growth factors capable of stimulating gu

140 The existence of slowly cycling, adult stem cells has been challenged by the identificati

141 Adult stem cells have an enormous potential for clinical

142 BACKGROUND & AIMS: Adult stem cells have been proposed to be quiescent and

143 Normal homeostatic functions of adult stem cells have rhythmic daily oscillations that a

144 ic mechanisms that control the activation of adult stem cells holds the promise of tissue and organ r

145 plays key roles in embryonic development and adult stem cell homeostasis and is altered in human canc

146 findings provide an insight in regulation of adult stem cells homeostasis by two major pathways with

147 dult intestine involves de novo formation of adult stem cells in a process controlled by T3.

148 Pw1 gene expression is a marker of adult stem cells in a wide range of tissues.

149 Here we show that adult stem cells in Drosophila melanogaster germline and

150 Local signals maintain adult stem cells in many tissues.

151 nce both understanding and implementation of adult stem cells in promoting myocardial repair.

152 d receptor 5 (LGR5) is a bona fide marker of adult stem cells in several epithelial tissues, most not

153 It is unclear how adult stem cells in solid organs respond to oncogenic st

154 a Wnt target gene and a bona fide marker of adult stem cells in the gastrointestinal tract and hair

155 es a supportive microenvironment to maintain adult stem cells in their undifferentiated state.

156 se findings demonstrate the critical role of adult stem cells in tissue remodeling and unravel the co

157 ids opens up avenues for the manipulation of adult stem cells in vitro, which could facilitate the st

158 entity, lineage commitment and plasticity of adult stem cells in vivo.

159 ses of ionizing radiation (IR) as a model of adult stem cell injury and identified a regeneration def

160 ed the transdifferentiation process of human adult stem cells into retinal ganglion-like cells and re

161 demonstrate that in vivo differentiation of adult stem cells is associated with small but informativ

162 The proliferation and differentiation of adult stem cells is balanced to ensure adequate generati

163 anding the regulation of chromatin states in adult stem cells is likely to have important implication

164 The activity of adult stem cells is regulated by signals emanating from

165 A unique property of many adult stem cells is their ability to exist in a non-cycl

166 ic development, especially in organ-specific adult stem cells, is unclear.

167 ator of mammalian germ lines, acts to commit adult stem cells, known as i-cells, to the germ cell fat

168 We suggest that all adult stem cells likely employ multiple, independently a

169 However, little is known about how the adult stem cell lineage contributes to hippocampal struc

170 olecular pathways that regulate an essential adult stem cell lineage in plants.

171 ific transcriptomes during development of an adult stem-cell lineage in the Arabidopsis leaf.

172 In adult stem cell lineages, progenitor cells commonly unde

173 In many adult stem cell lineages, the continuous production of f

174 ell signaling interactions within individual adult stem cell lineages.

175 In skeletal muscle, the adult stem cells maintain a quiescent state and prolifer

176 Adult stem cells maintain and regenerate multiple mature

177 How adult stem cells maintain self-renewing tissues is commo

178 Adult stem cells maintain tissue homeostasis by balancin

179 Germ cells and adult stem cells maintain tissue homeostasis through a f

180 Adult stem cells maintain tissue integrity and function

181 tional deregulation of key genes involved in adult stem cell maintenance and lineage specification.

182 g pathway controls embryonic development and adult stem cell maintenance through the regulation of tr

183 governs critical processes in embryogenesis, adult stem cell maintenance, and tumorigenesis.

184 gnalling pathway is crucial for development, adult stem cell maintenance, cell migration and axon gui

185 ranscription factor exclusively required for adult stem cell maintenance.

186 ating gene repression during development and adult stem cell maintenance.

187 of E9.5-E10.0 hepatoblasts that express the adult stem cell marker Lgr5, and generate both hepatocyt

188 e we report that Lgr5, a recently discovered adult stem cell marker, is exclusively expressed in GBCs

189 tion of Sca-1, one of the most commonly used adult stem cell markers.

190 n certain vertebrate classes, MG function as adult stem cells, mediating retinal regeneration in resp

191 Adult stem cells modulate their output by varying betwee

192 Whether the sexual identity of adult stem cells must also be maintained was not known.

193 Adult stem cells must limit their rate of protein synthe

194 Planarian flatworms contain a population of adult stem cells (neoblasts) that proliferate and genera

195 lining of the central canal that is also an adult stem cell niche.

196 p to address fundamental questions about the adult stem cell niche.

197 ion, which enables them to contribute to the adult stem-cell niche.

198 Although adult stem cell niches are organized by specialized supp

199 In addition, Bmp signals characterize adult stem cell niches in other tissues where Hopx-media

200 nerated to reproduce structures found within adult stem cell niches.

201 c neurons during mouse corticogenesis and in adult stem cell niches.

202 regeneration that may be conserved in other adult stem cell niches.

203 echanisms by which external signals regulate adult stem cell numbers, stem cell maintenance, and stem

204 Adult stem cells occur in niches that balance self-renew

205 Adult stem cells of diverse origins (e.g., bone marrow,

206 Satellite cells (SCs), the resident adult stem cells of skeletal muscle, are required for ti

207 rom pluripotent stem cells and germ cells to adult stem cells of the lung, liver, muscle, bone and ma

208 go whole-body regeneration using pluripotent adult stem cells of the neoblast population, can reversi

209 mild up-regulation of Bmi1 expression in the adult stem cells of the skeletal muscle leads to a remar

210 rug delivery vehicles such as nanoparticles, adult stem cells, or T cells in immunotherapy.

211 Adult stem cells, particularly those resident in tissues

212 xpression profiling of pluripotent planarian adult stem cells (pASCs), Onal et al present evidence fo

213 g DG assembly and the generation of a stable adult stem cell pool in routine housing and after stress

214 h DG assembly and ultimately diminishing the adult stem cell pool.

215 The clonal complexity of adult stem cell pools is progressively lost during homeo

216 gnaling during the asymmetric division of an adult stem cell population and in other BMP signaling co

217 cular Biology of the Cell describing a novel adult stem cell population isolated from adipose tissue-

218 s with this partner in the maintenance of an adult stem cell population.

219 which to define homeostatic mechanisms of an adult stem cell population.

220 tively maintaining the quiescent state of an adult stem-cell population.

221 In parallel, the use of endogenous adult stem cell populations alongside the recent applica

222 How adult stem cell populations are recruited for tissue ren

223 SC has gone on to be one of the most popular adult stem cell populations currently being used in the

224 tantly, homologous recombination can protect adult stem cell populations from genotoxic stress.

225 In characterizing four adult stem cell populations of glandular skin, we show t

226 PRC2 helps to maintain adult stem cell populations, but little is known about i

227 x anatomy of the epidermis contains multiple adult stem cell populations, but the extent to which the

228 c tissues often maintain their expression in adult stem cell populations, but whether their function

229 f dynamic heterogeneity in the regulation of adult stem cell populations.

230 roles in unsuspected places, for example in adult stem cell populations.

231 Embryonic and adult stem cells possess the capability of self-renewal

232 Thus, the GSCs, an adult stem cell present in a cellular niche, have a nich

233 s an allogeneic bone marrow-derived adherent adult stem cell product that has shown efficacy in precl

234 TFs) and is accompanied by the expression of adult stem cell programs, notably, active canonical Wnt

235 n with or without autologous adipose-derived adult stem cell recellularization within the corneal str

236 itical chromatin regulators, but its role in adult stem cell regulation remains unclear.

237 iated with telomere biology, senescence, and adult stem-cell regulation, have since gained support fr

238 drive chondrogenesis of these populations of adult stem cells remain poorly understood.

239 ls; however, a role for imprinting per se in adult stem cells remains elusive.

240 the impact on growth and differentiation of adult stem cells remains unclear.

241 lularization with autologous adipose-derived adult stem cells remains unclear.

242 and regeneration are mediated by programs of adult stem cell renewal and differentiation.

243 G protein-coupled receptor 5 (LGR5)-positive adult stem cells represent an exciting new cell source f

244 Adult stem cells reside in microenvironments called nich

245 Adult stem cells reside in specialized niches where they

246 Our results show that adult stem cells retain inherent LR asymmetry that elici

247 f skeletal muscle depends on a population of adult stem cells (satellite cells) that remain quiescent

248 Adult stem cell (SC) maintenance and differentiation are

249 cquire different cell fates are critical for adult stem cell (SC) potential, yet are poorly understoo

250 Long-lived and self-renewing adult stem cells (SCs) are essential for homeostasis in

251 Regulation of adult stem cells (SCs) is fundamental for organ maintena

252 Tissue regeneration relies on adult stem cells (SCs) that possess the ability to self-

253 t little is known about Mediator function in adult stem cell self-renewal and differentiation.

254 ed for the DNA damage-mediated disruption of adult stem cell self-renewal and lineage differentiation

255 Adult stem cells spontaneously differentiate in culture,

256 evidence from both pluripotent embryonic and adult stem cell studies suggests that this balance is pa

257 Adult stem cells support tissue homeostasis and repair t

258 yet distinct, roles in organ development and adult stem cell survival.

259 Adult stem cells sustain tissue maintenance and regenera

260 possibly because the best studied vertebrate adult stem cell systems are not readily amenable to in v

261 e essential for regeneration, which requires adult stem cells termed neoblasts.

262 ecently and developed culture conditions for adult stem cells that allow the long-term expansion of a

263 the entire lifetime by small populations of adult stem cells that are believed to reside in the bott

264 Satellite cells are resident adult stem cells that are required for regeneration of s

265 Instead, they have adult stem cells that contribute to somatic tissues or g

266 tal pulp stem cells (DPSCs), a population of adult stem cells that is known to participate in the rep

267 tion, individual memory T cells can serve as adult stem cells that provide robust regeneration of an

268 re the most thoroughly characterized type of adult stem cell, the intricate molecular machinery that

269 myocardial regenerative medicine mediated by adult stem cell therapy has gathered momentum fueled by

270 be useful to increase circulating levels of adult stem cells, thereby exerting beneficial effects on

271 ancer development as well as the survival of adult stem cells through potentiation of Wnt signaling.

272 the pluri- and multipotency of embryonic and adult stem cells, thus the germline and stem cells must

273 tenin, is crucially involved in development, adult stem cell tissue maintenance, and a host of diseas

274 also for the synchronized differentiation of adult stem cells to a specific lineage.

275 The goal of this study was to use adult stem cells to engineer anatomically shaped, functi

276 constructs containing either human fetal or adult stem cells to enhance functional repair of nude ra

277 ad Box O (FoxO) transcription factors act in adult stem cells to preserve their regenerative potentia

278 Clinical trials using adult stem cells to regenerate damaged heart tissue cont

279 recently shown to be expressed in mammalian adult stem cells to support self-renewal of neural and l

280 Next, we explored the ability of engineered adult stem cells to track metastatic deposits in this mo

281 cells, axonal growth cones and many types of adult stem cells, to specific areas distant from their o

282 Insights gained from clinical trials of adult stem cells, together with fundamental scientific a

283 ification for the use of RIC regimens in all adult stem cell transplant candidates with acute leukemi

284 tients underwent PET/CT 30 days after either adult stem cell transplantation (allogeneic cell transpl

285 e SpORF2 mRNA alone in human fibroblasts and adult stem cells triggers a senescence-like phenotype, w

286 Adult stem cells undergo asymmetric cell division to sel

287 Many adult stem cells use ACD as a means of maintaining stem

288 in applications to Ewing's sarcoma and human adult stem cells using publicly available and custom gen

289 ls can be derived either from pluripotent or adult stem cells via differentiation or by transdifferen

290 We show here that Lgr5, a marker for adult stem cells, was expressed in a subset of supportin

291 y regulate renewal versus differentiation of adult stem cells, we evaluated Wnt signal transduction i

292 Sox10(+) adult stem cells were found sparsely in the stroma of su

293 Autologous adipose-derived adult stem cells were obtained by elective liposuction a

294 Findings: Although adult stem cells were once believed to have the ability

295 issue maintenance and regeneration depend on adult stem cells, which are characterized by their abili

296 f stem cell biology, including embryonic and adult stem cells, will allow the scientific community to

297 nchymal stem cells (MSCs) are a prototypical adult stem cell with capacity for self-renewal and diffe

298 iferative embryonic stem cells and quiescent adult stem cells, with a focus on hematopoietic and musc

299 iferation, differentiation, and migration of adult stem cells within the tissues in which they exist.

300 ity may allow derivation of patient-specific adult stem cells without genetic manipulation and holds