ライフサイエンスコーパス: adult-born

1 pared with those generated in adulthood, and adult-born (AB) neurons with normal versus aberrant morp

2 ither early-born [EB; postnatal day (P)7] or adult-born (AB; P60) DGCs.

3 In particular, the relative contribution of adult-born (abGC) and mature (mGC) granule cells to epil

4 Both adult-born and early-born DGCs are targets of new inputs

5 identify and compare presynaptic inputs onto adult-born and early-born DGCs in the rat pilocarpine mo

6 ), whereas normotopic DGCs synapse onto both adult-born and early-born DGCs.

7 Adults born and raised at high altitudes have larger lun

8 Healthy adults born and raised at moderate altitude (2,000 m abo

9 Adjusted VE was similar in adults born before 1950, presumed primed by natural infe

10 Adjusted VE was similar in adults born before 1950, presumed primed by natural infe

11 red and one very premature-born adults (i.e. adults born before 32 weeks of gestation, and/or with bi

12 water fluoridation were at least as great in adults born before widespread implementation of fluorida

13 fering 1-time screening for HCV infection to adults born between 1945 and 1965.

14 Subjects were adults born both preterm and at term, with their childre

15 tructural remodelling where mature spines of adult-born but not early-born neurons relocate in an act

16 a 58% higher prevalence of obesity in young adults born by CS than in young adults born vaginally.

17 ally, learning required both the presence of adult-born cell and noradrenaline.

18 energic transmission significantly effect on adult-born cell survival and perceptual learning.

19 ampal BDNF protein levels, survival rates of adult born cells, and synaptic plasticity (long-term pot

20 on sensory activity, but when and how these adult-born cells acquire responsiveness to sensory stimu

21 litation, sprouted mossy fiber synapses from adult-born cells exhibited profound frequency-dependent

22 ay be critical for the contribution of young adult-born cells for certain tasks.

23 Thus, maturation of adult-born cells in both the DG and the MOB is much long

24 Deletion of FXR1 in aNSCs resulted in fewer adult-born cells in the dentate gyrus (DG) overall, redu

25 these manipulations on regional survival of adult-born cells in the OB.

26 a remarkably rapid functional integration of adult-born cells into the preexisting neural network.

27 representations, and the few spatially tuned adult-born cells remapped to a similar degree.

28 ine could directly influence the survival of adult-born cells.

29 esynaptic inputs than those of Ocn-Cre(-) or adult born dDG neurons.

30 GABA is a key regulator of adult-born dentate granule cell (abDGC) maturation so ma

31 underlying the integration and functions of adult-born dentate granule cell (DGCs) are poorly unders

32 continuously modified by the integration of adult-born dentate granule cells (abDGCs).

33 To understand how monosynaptic inputs onto adult-born dentate granule cells (DGCs) are altered in e

34 cuit-, and systems-based mechanisms by which adult-born dentate granule cells (DGCs) modulate pattern

35 modulate hippocampal adult neurogenesis, and adult-born dentate granule cells contribute to the patho

36 We found that adult-born dentate granule cells exhibit tortuous, yet h

37 havioral studies have established a role for adult-born dentate granule cells in discriminating betwe

38 of hippocampal neurons in vitro and in vivo Adult-born dentate granule cells lacking Trim9 similarly

39 lines can be used to label large cohorts of adult-born dentate granule cells with excellent time res

40 vitro and in vivo Embryonic hippocampal and adult-born dentate granule neurons lacking Trim9 exhibit

41 t remodeling of the afferent connectivity of adult-born dentate granule neurons.

42 we show that Disc1 knockdown specifically in adult-born dentate gyrus (DG) neurons results in increas

43 deletion, a significant number of Trim9(-/-) adult-born dentate neurons localized inappropriately.

44 ses the survival, but not the production, of adult-born DG granule cells, possibly because of greater

45 Subsequently, during differentiation of adult-born DG granule cells, Sema7A promotes dendrite gr

46 napses, whereas it restricts the survival of adult-born DG granule cells, which compete with mature g

47 n of adult-born DGCs transiently reorganized adult-born DGC local afferent connectivity and promoted

48 lar ectopic DGCs preferentially synapse onto adult-born DGCs after pilocarpine-induced status epilept

49 lf9), in mature DGCs enhanced integration of adult-born DGCs and increased NSC activation.

50 ver, somatostatin(-) interneuron inputs onto adult-born DGCs are maintained, likely due to preferenti

51 Adult-born DGCs are thought to compete with mature DGCs

52 ell backprojections that specifically target adult-born DGCs arise in the epileptic brain, whereas ax

53 nation of the DG by enhancing integration of adult-born DGCs in adulthood, middle age, and aging enha

54 Enhanced integration of adult-born DGCs transiently reorganized adult-born DGC l

55 mation is conveyed to RGLs, progenitors, and adult-born DGCs via the neurogenic niche that is compose

56 of Rac1 in mature DGCs increased survival of adult-born DGCs without affecting proliferation or DGC a

57 The events leading adult-born DGCs' to transition from simple spindle-like

58 tem cell (NSC) homeostasis and maturation of adult-born DGCs.

59 y integrated, expanded cohort of age-matched adult-born DGCs.

60 ing in regulating the initial integration of adult-born DGCs.SIGNIFICANCE STATEMENT Since the discove

61 RECOMMENDATION 1: Adults born during 1945-1965 should receive 1-time testi

62 roups, VE against A(H1N1)pdm09 was lower for adults born during 1957-1976 (25%; 95% CI, -16%-51%).

63 Adults born from 1945 through 1965 with 1 or more visits

64 irus (HCV) infection is most prevalent among adults born from 1945 through 1965, and approximately 50

65 lines enable simple and reliable labeling of adult-born GC lineages within restricted time windows.

66 contrast, mice lacking 5HT1ARs only in young adult-born GCs (abGCs) showed normal fluoxetine response

67 Our data suggest that as adult-born GCs age, their function switches from pattern

68 conditional expression of tdTomato (Tom) in adult-born GCs and characterized their development and f

69 aptic signaling for structural maturation of adult-born GCs and formation of glutamatergic synapses.

70 distinguishing them from less active, older adult-born GCs and the major population of dentate GCs g

71 reproduces data from mouse or rat, mature or adult-born GCs as well as pharmacological interventions

72 dia formation/retraction on the dendrites of adult-born GCs at the early maturational stages depended

73 on and retraction on the distal dendrites of adult-born GCs at their early maturational stages.

74 The slow development of adult-born GCs characterized here is consistent with pre

75 2B-containing NMDA receptor was deleted from adult-born GCs did not differ from controls in baseline

76 gs reveal an increased structural dynamic of adult-born GCs during the early stages of their integrat

77 tes the NMDAR-dependent filopodia dynamic of adult-born GCs during their early but not late maturatio

78 lopodia formation on the dendrites of mature adult-born GCs following NMDA iontophoresis.

79 etion of NR2B-containing NMDA receptors from adult-born GCs impairs a neurogenesis-dependent form of

80 s indicate that NR2B-dependent plasticity of adult-born GCs is necessary for fine contextual discrimi

81 We observed that, whereas adult-born GCs maintained stable cell-to-cell variabilit

82 tomical and electrophysiological analysis of adult-born GCs showed that olfactory learning promotes a

83 taining NMDARs promote synapse activation in adult-born GCs that integrate in circuits with high and

84 ation, synaptic integration, and survival of adult-born GCs when their afferent GABAergic inputs are

85 ynapse formation in developmentally born and adult-born GCs, and they provide support for SEMA5A cont

86 n the DG and reduces dendritic complexity of adult-born GCs, but does not impact their survival.

87 lentiviral vectors to selectively transfect adult-born GCs, we observed that overexpression of the p

88 roaches to precisely label entire cohorts of adult-born GCs.

89 that learning strengthens these inputs onto adult-born GCs.

90 ilopodia on the distal dendrites of immature adult-born GCs.

91 aptic densities of neonatal-born GCs than in adult-born GCs.

92 esponse to changes in neuronal activity than adult-born GCs.

93 occurred differently in mature neonatal- and adult-born GCs.

94 el odors and eventually led to the demise of adult-born GCs.

95 These adult-born granule cell (GC) interneurons form new GABAe

96 que features in the synaptic outputs made by adult-born granule cell interneurons in the mouse olfact

97 rinsic function and network incorporation of adult-born granule cells (ABGCs) after ischemia is uncle

98 Adult-born granule cells (ABGCs) are involved in certain

99 Adult-born granule cells (abGCs) have been implicated in

100 Young adult-born granule cells (abGCs) in the dentate gyrus (D

101 We examined the functional life history of adult-born granule cells (abGCs) in the olfactory bulb u

102 ary for the normal functional development of adult-born granule cells (abGCs) in the olfactory bulb.

103 ynamics and morphological characteristics of adult-born granule cells (abGCs), innervating the OB of

104 tle is known about the structural dynamic of adult-born granule cells (GCs) at their different matura

105 nal role of GluN2B for synapse maturation of adult-born granule cells (GCs) in the olfactory bulb has

106 Adult-born granule cells (GCs), a minor population of ce

107 estricted manner along the dendritic tree of adult-born granule cells (GCs).

108 we show that exclusive inhibition of JNK in adult-born granule cells alleviates anxiety and reduces

109 Using optogenetics, we demonstrate that adult-born granule cells born before SE form functional

110 We reveal that sprouted synapses from adult-born granule cells have a diminished ability to su

111 ed robust granule cell layer dispersion, and adult-born granule cells labeled with enhanced green flu

112 ed patterns of stable connectivity with MCs, adult-born granule cells show dynamic and plastic patter

113 Adult-born granule cells that were ectopically positione

114 unexplored, and the specific contribution of adult-born granule cells to functional mossy fiber sprou

115 ted synapses would limit the contribution of adult-born granule cells to hippocampal hyperexcitabilit

116 activated sprouted mossy fiber synapses from adult-born granule cells to study their synaptic propert

117 disorganization, and the ectopic position of adult-born granule cells within a malformed dentate gyru

118 rs for the activity-dependent integration of adult-born granule cells.

119 ocalization of the GGABA(B)R1 protein within adult-born granule cells.

120 , determination, and survival of hippocampal adult-born granule neurons are unaffected in the APP big

121 density in young (developing) but not mature adult-born-granule-cells (abGCs) in the olfactory bulb.

122 and effective) of the output connections of adult-born hippocampal cells to show that, as these cell

123 Adult-born hippocampal neurons are important for cogniti

124 Here we show that adult-born hippocampal neurons are required for normal e

125 ched experiences to increase the addition of adult-born hippocampal neurons by increasing the firing

126 avioral resiliency and increased survival of adult-born hippocampal neurons compared with sham-operat

127 rtin) or survival (bromodeoxyuridine) of new adult-born hippocampal neurons in adult male Sprague-Daw

128 Recent studies have implicated adult-born hippocampal neurons in pattern separation, a

129 ss this question is to link the functions of adult-born hippocampal neurons with specific endophenoty

130 us depression, including reduced survival of adult-born hippocampal neurons.

131 Accumulation of abnormally integrated, adult-born, hippocampal dentate granule cells (DGCs) is

132 ovirus mediated knockout of notch1 in single adult-born immature neurons decreases mTOR signaling and

133 found that Notch1 is highly expressed in the adult-born immature neurons in the hippocampus of mice.

134 ce exhibited a significantly greater loss of adult-born immature neurons within the dentate gyrus aft

135 jury (TBI) results in the selective death of adult-born immature neurons, compromising the cell popul

136 itutively activate Notch signaling in single adult-born immature neurons, promotes mTOR signaling and

137 esis between juvenile (born that season) and adult (born in previous seasons) males.

138 Adults (born in or after 1957) attending pretravel consu

139 irth year groups reporting AD, with 12.9% in adults born in 1936-1949 and 19.0% born in 1976-1988.

140 We used a birth cohort of 1400 young adults born in Jerusalem who had extensive archival data

141 We find that adult-born interneurons are resistant to presynaptic GAB

142 We further demonstrate that eliminating adult-born interneurons in naive animals leads to an exp

143 This dynamic decreased as the adult-born interneurons matured.

144 The maturation of adult-born interneurons was accompanied by a progressive

145 After arrival, adult-born JGNs are still migrating, but at DPI 9, 52% o

146 two-photon imaging of retrovirally labelled adult-born JGNs reveals that ~90% of the cells arrive at

147 ctors are also present in the large group of adults born late preterm.

148 tudinally imaged the developing dendrites of adult-born mouse dentate granule cells (DGCs) in vivo an

149 these developmental stages in embryonic and adult-born mouse hippocampal neurons in vitro and in viv

150 rimary cilium in the synaptic integration of adult-born mouse hippocampal neurons.

151 This review discusses the role of adult-born neural and glial progenitors in drug seeking

152 igin, division and migration patterns of the adult-born neural progenitor (NP) lineages in detail.

153 H-dependent suppression of LTP and prevented adult-born neuron loss.

154 MRP, we investigated whether learning shapes adult-born neuron morphology during their synaptic integ

155 strate that top-down neuromodulation acts on adult-born neuron survival to modulate learning performa

156 How an adult-born neuron with initially simple spindle-like mor

157 ite their small numbers and sparse activity, adult-born neurons (ABNs) in the DG play critical roles

158 Adult-born neurons adjust olfactory bulb (OB) network fu

159 Silencing of young adult-born neurons also produced changes extending to th

160 ns that are prevented by ablation of FMRP in adult-born neurons and rescued by an metabotropic glutam

161 link between the physiological functions of adult-born neurons and their roles in pathological condi

162 Each breeding season, new adult-born neurons are added to the pallial nucleus HVC

163 eurogenesis, the integration and survival of adult-born neurons are both strongly influenced by olfac

164 Adult-born neurons are continually produced in the denta

165 ablated neurogenesis, we find that maturing adult-born neurons are crucial only when memory must be

166 One area where neuroblasts that give rise to adult-born neurons are generated is the lateral ventricl

167 ippocampal NSCs and synaptic connectivity of adult-born neurons are inversely correlated with the lev

168 is generally assumed that by 2 months of age adult-born neurons are mature and equivalent to the broa

169 tantial number of studies demonstrating that adult-born neurons are necessary for mediating specific

170 Together, these results show that mature adult-born neurons are still plastic when they are funct

171 r experience-induced dendritic plasticity of adult-born neurons as spatial learning in the water maze

172 p63 regulates the numbers of adult NPCs and adult-born neurons as well as neural stem cell-dependent

173 le using optogenetics to transiently silence adult-born neurons at different ages.

174 We further discuss potential roles of adult-born neurons at the circuitry and behavioral level

175 The adult-born neurons at the misplaced position may make wr

176 These adult-born neurons become functionally active and are th

177 ersible genesis and synaptic connectivity of adult-born neurons between the demyelinated and remyelin

178 However, few have examined adult-born neurons beyond the critical period or directl

179 re located in brain clusters 9 and 10 (where adult-born neurons differentiate) and express appropriat

180 ic transmission is a key mechanism selecting adult-born neurons during learning and demonstrate that

181 However, the behavioral roles of adult-born neurons during their establishment of project

182 esults identify a restricted time window for adult-born neurons essential in hippocampal memory retri

183 he water maze sculpts the dendritic arbor of adult-born neurons even when they are several months of

184 It is believed that adult-born neurons exert their unique role in informatio

185 We find that young adult-born neurons fire at a higher rate in vivo but par

186 Here we assessed the destination of adult-born neurons following TBI.

187 Adult-born neurons formed functional synapses on CA3 pyr

188 Indeed, between 7 and 24 weeks, adult-born neurons gained additional dendritic branches,

189 Considering the small number of adult-born neurons generated at any given time, it is su

190 Compared with neonatal-born neurons, old adult-born neurons had greater spine density, larger pre

191 Conversely, optogenetic stimulation of adult-born neurons has been shown to specifically improv

192 The sequential synaptic integration of adult-born neurons has been widely examined in rodents,

193 birth date and reversibly control a group of adult-born neurons in adult mice.

194 d by a significant decrease in the number of adult-born neurons in both the DG and OB.

195 Morphological analysis of adult-born neurons in both the DG and the OB showed that

196 Irradiation reduced the number of adult-born neurons in both wild-type and Ccr2(-/-) mice,

197 se studies identify hemocytes as a source of adult-born neurons in crayfish and demonstrate that the

198 Here, we report that adult-born neurons in crayfish can be derived from hemoc

199 morphological features of 2- to 24-week-old adult-born neurons in male rats.

200 vity is required selectively for survival of adult-born neurons in response to BDNF signaling.

201 terneurons and points to a critical role for adult-born neurons in stabilizing a brain circuit that e

202 Two decades after the discovery of adult-born neurons in the brains of decapod crustaceans,

203 Appropriate generation and incorporation of adult-born neurons in the dentate gyrus are critical for

204 t studies have led to the exciting idea that adult-born neurons in the dentate gyrus of the hippocamp

205 anular zone, yet decreased the proportion of adult-born neurons in the dentate gyrus.

206 ic deletion of IL-17 increased the number of adult-born neurons in the DG.

207 ion, maturation, and dendritic complexity of adult-born neurons in the DG.

208 Adult-born neurons in the hippocampal dentate gyrus are

209 The aberrant migration of adult-born neurons in the hippocampus occurred 48 hours

210 ed that experience elevates the abundance of adult-born neurons in the hippocampus primarily by enhan

211 cently been observed to serve as a source of adult-born neurons in the mammalian brain.

212 In addition, to establish the origin of adult-born neurons in the MOB, an adeno-associated virus

213 neuronal excitability of in vivo individual adult-born neurons in the mouse dentate gyrus via expres

214 While adult-born neurons in the olfactory bulb (OB) and the de

215 ate gyrus reduce the survival of hippocampal adult-born neurons in wild-type but not in NFATc4(-/-) m

216 Conditional deletion of cilia from adult-born neurons induced severe defects in dendritic r

217 hat control the migration and integration of adult-born neurons into circuits are largely unknown.

218 ffer direct support for rapid integration of adult-born neurons into existing circuits, followed by e

219 es are indicative of enhanced integration of adult-born neurons into the bulbar circuitry of lactatin

220 ies has suggested that the function of these adult-born neurons is linked to cognition and emotion.

221 unclear whether expanding the population of adult-born neurons is sufficient to affect anxiety and d

222 n, Temprana et al. (2015) show that immature adult-born neurons largely function independently of inh

223 Because the generation of adult-born neurons may be tightly coupled to their funct

224 Accumulating evidence suggests that adult-born neurons may play distinct physiological roles

225 environment are rapid, the synaptogenesis of adult-born neurons occurs over a longer time scale.

226 specifically, by targeting the cell death of adult-born neurons or by other mechanisms, may have ther

227 During immature stages, adult-born neurons pass through critical periods for sur

228 We discovered that adult-born neurons promote location discrimination durin

229 Local CRH signaling onto adult-born neurons promotes and/or stabilizes chemical s

230 c link between these effects by showing that adult-born neurons receive noradrenergic projections and

231 aled that the malleable dendritic portion of adult-born neurons receives excitatory inputs mostly fro

232 These findings indicate that maturing adult-born neurons regulate both functional network plas

233 encode experiences to affect the addition of adult-born neurons remains unknown.

234 type 1 NSCs and dendritic spine densities of adult-born neurons reverted to normal in the hippocampus

235 ls that regulate survival and integration of adult-born neurons such as neurotrophins and neurotransm

236 ndritic architecture and spine morphology of adult-born neurons that are prevented by ablation of FMR

237 -19 in preventing the irregular migration of adult-born neurons that may contribute to the etiology o

238 cible genetic expansion of the population of adult-born neurons through enhancing their survival impr

239 -) mice, but the distribution pattern of the adult-born neurons through the granule cell layer was on

240 ts their neurogenic proliferation to produce adult-born neurons throughout life.

241 tocol and reduced the survival of 4-week-old adult-born neurons throughout the adult hippocampus.

242 ates structural plasticity of olfactory bulb adult-born neurons to support olfactory learning through

243 extracts clues regarding the contribution of adult-born neurons to the different circuits of the olfa

244 currents with fast kinetics do not appear in adult-born neurons until several weeks after cell birth.

245 l neurogenesis and structural development of adult-born neurons using a Cup/Rap model, which recapitu

246 d that the integration of lentivirus-labeled adult-born neurons was biased: newly formed neurons were

247 Furthermore, we show that fewer adult-born neurons were active during recall of the CS s

248 on, maturation, and dendritic development of adult-born neurons were impaired.

249 In addition, dendritic spine densities of adult-born neurons were significantly decreased, indicat

250 neonatal-born neurons may additionally endow adult-born neurons with unique functions even after they

251 Neurons that arise in adults (adult-born neurons) show heightened synaptic plasticity

252 erneurons, as well as hilar mossy cells, new adult-born neurons, and recently active neurons.

253 Primary cilia were absent in young adult-born neurons, but assembled precisely at the stage

254 dor learning is sensitive to inactivation of adult-born neurons, revealing that developmentally defin

255 at GABA regulates the initial integration of adult-born neurons, similar to neuronal development duri

256 Excitability is enhanced in maturing adult-born neurons, spurring the hypothesis that the act

257 ore, associated with the reduced survival of adult-born neurons, the absence of NFATc4 leads to selec

258 To assess the behavioral importance of adult-born neurons, we developed a novel knock-in mouse

259 In the OB, we focused on adult-born neurons, which are continuously incorporated

260 reorganization of connections impinging onto adult-born neurons, which is likely to have important im

261 al neurogenesis and synaptic connectivity of adult-born neurons, which play an essential role in cogn

262 omotes input-specific synaptic plasticity in adult-born neurons, which reinforces the top-down influe

263 the first-generation precursors that produce adult-born neurons, which reside in a neurogenic niche,

264 ease of alphaCaMKII dendritic translation in adult-born neurons.

265 ce and a mechanism of circuit integration of adult-born neurons.

266 esis, many studies rely on quantification of adult-born neurons.

267 ogenesis processes and special properties of adult-born neurons.

268 al disorders may be caused by disruptions in adult-born neurons.

269 work adaptations provided by the addition of adult-born neurons.

270 directly regulating the survival of immature adult-born neurons.

271 nsory experience, relates to the survival of adult-born neurons.

272 -driven prosurvival signaling in hippocampal adult-born neurons.

273 ritic refinement and synaptic integration of adult-born neurons.

274 ts are continuously molded by the arrival of adult-born neurons.

275 th compensation in the birth and survival of adult-born neurons.

276 Golgi localization and dendrite formation in adult-born neurons.

277 We found that selective deletion of MeCP2 in adult-born new neurons impaired their long-range connect

278 The recruitment of adult-born OB neurons depends not only on sensory input

279 Using an olfactory learning task requiring adult-born olfactory bulb neurons and cell-specific abla

280 al differentiation and long-term survival of adult-born olfactory bulb neurons.

281 Consistent with that, we found that adult-born OLs elaborated much shorter but many more int

282 It is not known whether adult-born OLs ensheath previously unmyelinated axons or

283 We conclude that adult-born OLs in the optic nerve are engaged in myelin

284 Therefore, how integration of adult-born OSNs may contribute to lifelong OB plasticity

285 Adults born outside the United States had less affected

286 cing the incorporation of defined classes of adult-born PGCs and not GCs, reflecting their different

287 n+ PGCs, suggesting that distinct subsets of adult-born PGCs may respond differentially to common ext

288 ighlights that fat deposition is enhanced in adults born preterm and suggests that ectopic fat accret

289 insulin secretion and insulin sensitivity in adults born preterm and their children.

290 s most apparent for systolic function; young adults born preterm had significantly lower right ventri

291 Young adults born preterm have distinct differences in left ve

292 In conclusion, adults born preterm have insulin resistance in midadulth

293 Studies were identified through the Adults born Preterm International Collaboration and by s

294 Adults born preterm were less insulin sensitive than tho

295 breeding season is due to the integration of adult-born projection neurons.

296 In this study, we quantified the number of adult-born striatal cells and characterized their fate i

297 The study included 1024 young adults born to mothers who were participating in the Wes

298 ity in young adults born by CS than in young adults born vaginally.

299 for ophthalmologic follow-up of children and adults born very prematurely.

300 Therefore, pattern separation requires adult-born young GCs but not old GCs, and older GCs cont