ライフサイエンスコーパス: advance

1 espan-extending intervention up to a year in advance.

2 were notified of their successive nature in advance.

3 iquid electrolyte is directly visualized via advanced 3D chemical analysis.

4 aluation through human trials is crucial for advancing a vaccine candidate to clinics.

5 Patients with advanced ACC were enrolled in a phase II study to evalua

6 We then discussed the advances achieved for various LDG sensing and biosensing

7 Advanced adenoma detection rate was lower in the first F

8 od that patients with adenomas would develop advanced adenomas, a surrogate for CRC.

9 n pump inhibition by ouabain), a significant advance against state of the art cell based sensors.

10 Current prediction models for advanced age-related macular degeneration (AMD) are base

11 rophy, previously suggested as a new form of advanced AMD, and herein replicated.

12 ress of genetics, genomics, biochemical, and advanced analytical techniques to dissect the biosynthet

13 ical challenges that need to be addressed to advance and solidify our comprehension of the importance

14 methods that take advantage of computational advances and multiscale modeling for the analysis of com

15 I, 1.4 to 1.7; observed, 473; EAR, 18.2) for advanced- and early-stage cHL, respectively, compared wi

16 rchers to enhance collaboration and research advances; and (3) novel research methods that take advan

17 venue to allow molecular medicine to rapidly advance, answers questions that traditional intervention

18 Recent advances are accessing longer time scales, larger action

19 These recent technological advances are improving the scale and resolution with whi

20 these combined therapies in the treatment of advanced atherosclerosis.

21 these combined therapies in the treatment of advanced atherosclerosis.

22 reg cells (SuperTreg cells) that can resolve advanced autoimmunity, with Brg1 re-expression in a mino

23 single-atom catalytic electrodes design for advanced battery systems is addressed.

24 erapy is effective in treating patients with advanced BC after resistance to TAM and aromatase inhibi

25 With new developments in the area of advanced biobased fibers, it would be possible to compet

26 ctors, but also new links of the plasmids to advanced bioinformatic tools.

27 ustness of prediction and classification and advances biomarker discovery.

28 or the development of prognostic markers for advanced BLCA.

29 Background Despite advances, blood oxygen level-dependent (BOLD) cardiac MR

30 at least one previous line of treatment for advanced breast cancer or relapsed within 12 months of n

31 g bacteria to clean-up oil spills is rapidly advancing but faces regulatory hurdles and environmental

32 s review is to highlight and summarize those advances by discussing the respective articles, publishe

33 Our homomorphic encryption advances can also be applied to other domains where larg

34 .01), and had lower odds of an FN finding of advanced cancer (odds ratio, 0.9 [95% CI: 0.5, 1.5]).

35 allel-group, randomised trial, patients with advanced cancer, aged at least 18 years, admitted to the

36 anticancer T cell responses in patients with advanced cancers.

37 xcellent properties and being selected as an advanced candidate.

38 This advanced cellular construct based on a combinatorial nan

39 (escalation, n = 12; expansion, n = 9) with advanced chondrosarcoma received ivosidenib (women, n =

40 c acid-enhanced MRI identified patients with advanced chronic liver disease who are at increased risk

41 In patients with advanced CLL, a 5 x 10(8) dose of CART-19 may be more ef

42 of 31 eyes from 31 consecutive patients with advanced Coats disease at an average age of 47.8 +/- 34.

43 vels were significantly higher in NAFLD with advanced compared with earlier stages of liver fibrosis.

44 In Malawi, 236 participants from the Advancing Cryptococcal Meningitis Treatment for Africa t

45 d samples were analyzed using UHPLC-HRMS and advanced data analysis tools.

46 nerated with these tools, when combined with advanced data science approaches, can be used to generat

47 s more slowly at first but more quickly with advancing decay, which resolves ambiguity about the afte

48 Among other advances, deep-learning machine learning methods, includ

49 New research advances demonstrate that FGF23 is also linked to iron e

50 ccumulated knowledge, principles, and recent advances, discussed in this review, can be utilized in t

51 host adaptive immune pathways to profoundly advance disease severity.

52 y melanoma lesion will metastasize and cause advanced disease, but underlying mechanisms are not enti

53 LAMA2-CMD patients are often diagnosed after advanced disease, it is unclear if laminin-111 protein t

54 ic failure at the site of implantation in an advanced disease.

55 d for prostate cancer staging, especially in advanced disease.

56 LC have brain metastases at the diagnosis of advanced disease.

57 The National Kidney Registry (NKR) Advanced Donation Program enables living donors the oppo

58 These results lay the foundation for new advanced droplet techniques with transformative applicat

59 the understanding of which can substantially advance drug discovery efforts.

60 Throughout, we highlight priorities for advancing each of these areas.

61 th the Li anode and the LCO cathode, with an advanced electrolyte, are reported.

62 These results provide guidance for designing advanced EMI shielding materials but also highlight the

63 mutations are present at a high frequency in advanced endocrine-resistant ER(+) breast cancer.

64 Patients with advanced endometrial carcinoma have limited treatment op

65 Here, I use an advanced energy balance model to show that such an HZ wo

66 The results suggest that by employing advanced ensemble methods and using past information, it

67 Here, we advance existing hypotheses with a new framework that ac

68 ss, refraction, and (glare) visual acuity in advanced FECD.

69 Despite this advance, few genetic interactions have been reproduced a

70 AUCs for discriminating advanced fibrosis (CPA >10.3%) were 0.86 (95% CI: 0.76,

71 h HFpEF and NAFLD also appeared to have more advanced fibrosis including cirrhosis suggesting a poten

72 ons of cirrhosis, or liver-related death) or advanced fibrosis/non-alcoholic steatohepatitis (NASH) i

73 provides a detailed overview of the rapidly advancing field of biofabrication, particularly with reg

74 DNA nanotechnology is a rapidly advancing field, which increasingly attracts interest in

75 ssible disease incidence at least 2 weeks in advance for any location or grid over India.

76 This review article focuses on the recent advances for the development of ocular drug delivery sys

77 future directions and enabling technological advances for the field are discussed.

78 Only 15% of drugs advance from Phase II to approval, with ineffective targ

79 gical viability of these Xe-Fe oxides, which advance fundamental knowledge for understanding xenon ch

80 sing ctDNA sequencing in 1,687 patients with advanced gastrointestinal (GI) cancer in SCRUM-Japan GOZ

81 genome, transcriptome, and functional assays advance general understanding of the Antarctic green alg

82 95% CI, 2.6-6.2]; P < 0.001) and moderate to advanced glaucoma (mean, 34.7% and 38.5%, respectively;

83 Advanced glaucoma was defined by a cup-to-disc ratio of

84 NFL thickness remains the most efficient for advanced glaucoma.

85 xtract on the formation of total fluorescent advanced glycation end products (AGEs) and Amadori adduc

86 oncentrations of sRAGE (soluble receptor for advanced glycation end products) strongly associate with

87 Advanced glycation end-products (AGEs) accumulate during

88 These advances have also revealed new challenges and opportuni

89 Exciting advances have been made over the past several years in e

90 However, these advances have not directly transferred to metagenomic da

91 These and other advances have opened new avenues for the medicinal chemi

92 l failure of AR antagonists in patients with advanced HCC by evaluating potential resistance mechanis

93 to compare safety profiles for patients with advanced HCC.

94 e is known about the mutational landscape of advanced hepatocellular carcinoma (HCC), and predictive

95 portive care in the second-line treatment of advanced hepatocellular carcinoma over a lifetime horizo

96 d, histologically or cytologically confirmed advanced HER2-negative breast cancer, an Eastern Coopera

97 tum-expectorating hospitalized patients with advanced HIV and access to both tests, concurrent testin

98 reast cancer subtypes has driven therapeutic advances; however, basal-like breast cancer (BLBC) remai

99 We have employed advanced imaging flow cytometry (iFCM) to explore the ki

100 Using advanced imaging methods and quasi-classical and fully q

101 lens formulas, intraoperative guidance, and advanced imaging technology and software have contribute

102 Advance in determining cardiac lineage diversification h

103 ole blood ELISpot assay offers a significant advance in the ability to immunophenotype patients with

104 lar degeneration (AMD) is a highly effective advance in the retinal armentarium.

105 We combine fluid dynamics and advanced in situ transmission electron microscopy analys

106 Recent advances in adapting deep architectures to structured da

107 New advances in algal and microencapsulation technology prov

108 We further present advances in animal models that are important for underst

109 Advances in anion transport by synthetic supramolecular

110 ioinspired electronics are rapidly promoting advances in artificial intelligence.

111 ase CRISPR-Cas technology has led to radical advances in biology.

112 a major challenge that requires significant advances in both mechanistic understanding and material

113 Advances in cancer screening methods have opened avenues

114 unt for current staging, disease biology, or advances in cancer treatments.

115 Rapid advances in cellular engineering(1,2) have positioned sy

116 t-child turn-taking are both associated with advances in children's language learning.

117 Recent advances in chromosome conformation capture experiments

118 -established technology, whereas fundamental advances in CO(2) electrolysis are still needed to enabl

119 Advances in cryo-electron microscopy are enabling increa

120 When combined with advances in dedicated image analyses and processing meth

121 Advances in developmental and stem cell biology have all

122 Despite advances in directing the assembly of biomacromolecules

123 We leverage advances in earthquake monitoring with a deep-learning a

124 Continued advances in fundamental immunology, genetic engineering,

125 urgence is primarily driven by technological advances in genetic engineering and metabolism as well a

126 cise instrumentation together with important advances in genetics, cell biology and spectroscopy.

127 ence of authentic human beta-cell lines, and advances in genome-editing technologies coupled with imp

128 Advances in imaging methods such as electron microscopy,

129 inal changes that have been identified using advances in imaging technology, analysis of current rese

130 Recent seminal advances in itch circuitry within the nervous system hav

131 Recent advances in long-read sequencing solve inaccuracies in a

132 us closed-loop experimentation combined with advances in machine learning (ML) is uniquely suited for

133 Although recent advances in mass spectrometry (MS) have enabled meaningf

134 Cancer imaging, in particular, has leveraged advances in MI agents and technology to improve the accu

135 The recent advances in microbiome science have highlighted the impo

136 Recent advances in molecular techniques have led to significant

137 Recent advances in new cancer treatment modalities (e.g., gene

138 In the past year, there have been numerous advances in our understanding of arrhythmia mechanisms,

139 Advances in our understanding of drug block and inactiva

140 This review summarises recent advances in our understanding of its clinical presentati

141 Advances in our understanding of the fundamental chemist

142 This review aims to focus on recent advances in peptide-functionalized liposomal formulation

143 We posit that these advances in pharmacological targeting of DUBs establish

144 Recent research advances in photonics have sparked interest in using a n

145 ute numbers of people affected suggests that advances in prevention and management of major neurologi

146 Recent advances in protein profiling technology has facilitated

147 tial role of hsTYR in human pathologies, the advances in recombinant expression systems and structura

148 This review highlights key advances in scalable biocatalytic C-H oxyfunctionalizati

149 Recent advances in scanning probe microscopy on surface enable

150 These efforts are propelled by advances in single cell profiling.

151 Our recent advances in stochastic separability of highdimensional d

152 Recent advances in technology have made the creation of high qu

153 In this review, the recent advances in the application of MOFs in heterogeneous cat

154 at the individual patient level has hindered advances in the field beyond the current therapeutic sta

155 s as 'proteomimetics' and discuss the recent advances in the field.

156 Despite advances in the identification of intermediates, elucida

157 ions having served as refugia during glacial advances in the late Quaternary Period.

158 enome editing tools continues to drive major advances in the life sciences.

159 Despite nearly three decades of advances in the management of rheumatoid arthritis (RA),

160 Recent advances in the physical understandings of self-assembly

161 res, the coming years will probably see many advances in the study of acid-sensing ion channels.

162 Recent advances in the study of the human visual system suggest

163 Despite advances in the treatment of diabetes mellitus, the path

164 It was recognized that advances in the understanding of basic mechanisms and th

165 In this review, we discuss recent advances in the understanding of the UPR, emphasizing co

166 This review highlights the advances in the use of MOFs in the elimination (adsorpti

167 Through this, we emphasize recent advances in therapeutics and pinpoint disease-associated

168 This review summarises advances in understanding C. difficile germination and o

169 eived the most focus, leading to significant advances in understanding of disease mechanisms, widely

170 This review will focus on recent advances in understanding the roles of B cell precursor

171 le zoonotic cryptosporidiosis looking at new advances in veterinary, public, and environmental health

172 ynthetic lethality is not a new idea, recent advances, including CRISPR-based gene editing, have made

173 he mean duration between sea-ice retreat and advance increased from 109 to 160 days (p = .004).

174 ed units characterize the crystal cargo, and Advanced-InSAR analysis highlights active deformation in

175 n (ITx) can be life-saving for patients with advanced intestinal failure experiencing complications o

176 limiting the number of compounds that can be advanced into clinical studies.

177 We randomly assigned 777 patients with advanced kidney disease and moderate or severe ischemia

178 PEC strains have been associated with severe advanced kidney pathologies, such as cystitis and pyelon

179 the Lawrence Berkeley National Laboratory's Advanced Light Source (ALS) has been used in conjunction

180 however serious AEs can occur in those with advanced liver disease.

181 with NAFLD, but the majority do not develop advanced liver disease: cirrhosis, hepatic decompensatio

182 ta have been analyzed, using a wide array of advanced Machine Learning techniques, to quantify how re

183 t alone any of the specific subtypes, except advances made for patients with CD30-positive anaplastic

184 Herein, the recent research advances made in porous electrocatalysts for these five

185 tal adenocarcinoma (PDAC) have lagged behind advances made in the treatment of many other malignancie

186 ctive will provide an overview of the recent advances made in understanding the role of each immunoph

187 demonstrations and subsequent development of advanced materials for solid-state laser refrigeration.

188 to the reproductive decline associated with advanced maternal age.

189 Administration-approved targeted therapy for advanced MCC.

190 esistance in PDAC and suggests a context for advancing MEKi use in the clinic.

191 ial aconitase activity in the development of advanced metastatic prostate cancer and suggests that bl

192 rug discovery, we review key applications of advanced methods for sampling complex free-energy landsc

193 with permanent functional deficit even after advanced microsurgical repair.

194 xt of natural freely moving behaviors, could advance models of sensory processing.

195 The utility of advanced MRI sequences such as diffusion-weighted imagin

196 Using advanced multivariate statistical analysis, we also show

197 Advanced nanodevices require reliable nanocomponents whe

198 Patients with advanced NASH (NASH Clinical Research Network stage F3 o

199 longitudinal joint model to estimate risk of advanced neoplasia at each subsequent examination after

200 mall adenomas at baseline have a low risk of advanced neoplasia over 10 years.

201 wastewater results can provide considerable advance notice of infection dynamics.

202 uenza antigen structure and immunobiology is advancing novel vaccine candidates into human trials.

203 Patients with previously treated advanced NSCLC received nivolumab monotherapy (3 mg/kg e

204 Methods: Seventy-two patients with advanced NSCLC were recruited in a single-institution an

205 opportunity to donate altruistically, or in advance of a potential recipient's transplant, and to re

206 We found marked advance of liver fibrosis (chronic damage), as well as n

207 nd the lack of resources sometimes limit the advance of radiologic research.

208 ns to characterize reactions in crystallo in advance of the beamtime.

209 Yet despite the promising advances of affinity grids over the past decades, no sin

210 readily downloadable from MISCAST to foster advanced offline analysis of missense variants by a wide

211 Human advance on natural habitats is a major cause of biodiver

212 In this article, we discuss recent advances on these nonconventional ubiquitin chains in ne

213 (like heat assisted extraction) to the most advance ones (such as ultrasound, microwave or supercrit

214 rgeted systemic therapy may be used to treat advanced or metastatic cancer using the same indications

215 oint therapy in BRAF(V600) mutation-positive advanced or metastatic melanoma.

216 r cisplatin-ineligible patients with locally advanced or metastatic urothelial carcinoma.

217 The kinomorphs may significantly advance organ-scale tissue construction by extending the

218 ic and kinetic parameters obtained here will advance our fundamental understanding of the surface che

219 cancer progression and thus modeling it will advance our understanding of cancer growth dynamics and

220 print for decoding signaling selectivity and advance our understanding of molecular recognition princ

221 To advance our understanding of the etiology of blinding di

222 Together, these findings advance our understanding of the mechanisms by which the

223 novel insights into beta-PE biosynthesis and advance our understanding of the mechanisms guiding lyas

224 These findings advance our understanding of thermoregulation in the dis

225 Recent research and guideline updates have advanced our understanding and management of ColdU.

226 This study advances our fundamental understanding of redox mechanis

227 This finding advances our knowledge of how ganglion neurons generate

228 This work advances our understanding of class B GPCR activation an

229 This work advances our understanding of the dynamics and functions

230 rack animals across the globe, significantly advancing our understanding of animal movement [1, 2].

231 iptomics technologies have vast potential in advancing our understanding of biology and disease.

232 While Ocean modeling has made significant advances over the last decade, its complex biological co

233 views the biological and medicinal chemistry advances over the past 3 decades with an emphasis on the

234 parameter for the design and operation of an advanced oxidation process (AOP) in water treatment.

235 become a standard therapy for patients with advanced PDAC and can be used to potentially downstage d

236 cise time window during which spring weather advances phenology varies considerably across each speci

237 Advanced phenotyping of cardiovascular diseases has evol

238 fe delivery of high-quality cancer care; (3) advance policies to ensure oncology providers have suffi

239 load, and burnout among the intensivists and advanced practice providers of established U.S. and Cana

240 ution, metastasis and drug response, and may advance precision oncology.

241 herapy remains a major challenge in treating advanced prostate cancer.

242 These advances provide exciting opportunities to profoundly tr

243 lines their potential for the realization of advanced quantum devices.

244 cts multiply and the speciation process then advances rapidly.

245 Poleward latitudinal advance rates differed significantly among regions, bein

246 de are now standard of care in patients with advanced RCC.

247 ed interobserver agreement was observed with advanced reconstruction compared with standard 4-mm reco

248 The advanced reconstruction methods did not increase interob

249 organoid biobank from patients with locally advanced rectal cancer (LARC) treated with neoadjuvant c

250 bnormally high blood levels in patients with advanced renal diseases.

251 Notwithstanding the advances reported in this field, there is compelling dem

252 ed RT, exciting opportunities they offer for advancing research and clinical care, hurdles to be over

253 pportunities that these devices have for the advanced sensing of pharmaceutical compounds toward safe

254 ypothesize that metabolic derangement due to advanced shock in critically injured patients leads to t

255 ospective exploratory study, 8 patients with advanced solid malignancies and an indication for sorafe

256 Cardiovascular alterations were monitored by advanced speckle tracking echocardiography, gene express

257 unclear if laminin-111 protein therapy at an advanced stage of the disease can have beneficial outcom

258 dence interval [CI]: 1.01, 3.5; P = .04) and advanced stage PDAC (10.8 months vs 18.0 months; HR, 2.1

259 as predictors of 5-year OS in patients with advanced-stage CRC.Keywords: Abdomen/GI, CT, Comparative

260 hed strategy for women with newly diagnosed, advanced-stage epithelial ovarian cancer.

261 was performed in 110 localized-stage and 556 advanced-stage FL patients.

262 Nevertheless, the majority of advanced-stage prostate cancer patients, including those

263 force-jump experiments, in combination with advanced statistical analysis, to show that octanoyl-CoA

264 We studied ART-naive participants from the ADVANCE study randomized to the efavirenz /emtricitabine

265 high postoperative morbidity, requirement of advanced surgery, and pelvic recurrence after regrowth t

266 responses, which may spread to produce more advanced systemic inflammation.

267 Advanced systemic mastocytosis (advSM) is characterized

268 Despite recent advances, targeted delivery of therapeutic oligonucleoti

269 a novel, biomimetic, human bone platform for advanced testing of implants in vitro, and demonstrate t

270 Here, we review recent advances that have contributed to the principal methods

271 ncise history of the foundational conceptual advances that helped define the field of chiral nanomate

272 ing have provided important opportunities to advance the academic careers of young investigators whil

273 These results advance the feasibility of a real-time, non-invasive hyp

274 ent of malaria to protect this age group and advance the goal of malaria elimination, while weighing

275 ges and discuss potential approaches to help advance the promotion of women in the sciences.

276 To advance the scientific understanding of bacteria-driven

277 To advance the sensitivity and spatial resolution of cellul

278 These results advance the understanding of poorly characterized ER str

279 espite whole tissue biopsy studies that have advanced the mechanistic understanding of AD, single cel

280 development of future interventions aimed at advancing the timing of food intake.

281 re is essential to interface electronics and advance their quantum applications.

282 ects of ocular drug discovery and the recent advances therein.

283 e technologies, and how new discovery may be advanced through machine learning approaches.

284 theless, candidate HIV interventions for men advance to clinical trials without preclinical efficacy

285 ture the varied reasons why vaccines fail to advance to regulatory approval.

286 le fraction of adults would be sufficient to advance to the clinic.

287 186 references were identified, 4,162 papers advanced to abstract review, and 1,826 underwent full-te

288 Several of these inhibitors have advanced to clinical trials, both singly and in combinat

289 a compelling data package, 20 (AM-6494) was advanced to preclinical development.

290 Here, using advanced tools for real-time visualization of native YAP

291 ependence occurs in approximately 15%-20% of advanced treatment-resistant prostate cancers, and this

292 stream of RB1, inactivated in SCLC and other advanced tumors, could have a broad impact on its treatm

293 l has shaped the field of cancer biology and advanced understanding of cancer pathophysiology.

294 Advancing understanding of neuron-cancer interactions wi

295 e 800 treated seeds, 415 germinated and were advanced up to four (M4) generations by selfing.

296 ioned to harness such innovations due to its advanced use of electronic health-care records and the d

297 sease-free survival in patients with locally advanced UTUC.

298 physicians willing to overcome resistance to advances were able to bring medical practice in Malaga t

299 trast-reversing gratings that response phase advances with grating spatial phase.

300 To advance XL-MS studies, we have previously developed a se