ライフサイエンスコーパス: adverse effect

1 lol use, and would be considered a very rare adverse effect.

2 liver tumor xenografts without inducing any adverse effect.

3 ts that result in significant toxicities and adverse effects.

4 ldwide, they are associated with significant adverse effects.

5 apeutic efficacy and minimize the off-target adverse effects.

6 d at all mass levels and not associated with adverse effects.

7 nge that did not induce cholinergic-mediated adverse effects.

8 of the protein in mice demonstrated lack of adverse effects.

9 None of the participants experienced serious adverse effects.

10 and a need for targeted therapies with fewer adverse effects.

11 py seems to carry a higher risk of long-term adverse effects.

12 ion fraction and instead was associated with adverse effects.

13 nts were withdrawn from the study because of adverse effects.

14 ver, current therapies are suboptimal due to adverse effects.

15 is complicated by an equally broad range of adverse effects.

16 ytotoxic immunosuppressives, which can cause adverse effects.

17 se medications has declined due to perceived adverse effects.

18 herapeutic efficacy while minimizing risk of adverse effects.

19 are partially ineffective and cause serious adverse effects.

20 ance tumor control, hearing preservation and adverse effects.

21 ncer treatment has been shown to promote the adverse effects.

22 ny clinically significant treatment emergent adverse effects.

23 of preventive strategies can minimize these adverse effects.

24 optimizes cellular responsiveness and limits adverse effects.

25 despite its association with a multitude of adverse effects.

26 ove outcomes and reduce risk of drug-induced adverse effects.

27 ated with serious and often life-threatening adverse effects.

28 tment may be ineffective and associated with adverse effects.

29 he pharmacokinetic challenges and off-target adverse effects.

30 continue administering it because of certain adverse effects.

31 but clinically problematic due to the drug's adverse effects.

32 over phenobarbital without increased serious adverse effects.

33 s increases the risk of treatment-associated adverse effects.

34 , including several that are associated with adverse effects.

35 ose intravenous adrenaline, with no reported adverse effects.

36 cial for linking DBS-induced therapeutic and adverse effects.

37 to reduce the risk of both known and unknown adverse effects.

38 res follow-up and reevaluation for potential adverse effects.

39 ioids remains widespread despite significant adverse effects.

40 ects on cognition, and there were no serious adverse effects.

41 ministration can lead to potentially serious adverse effects.

42 ncer immune responses but also their role in adverse effects.

43 den may account for important health-related adverse effects.

44 reductions, while that of Inner Mongolia has adverse effects.

45 h dose-escalated RT, pattern of failure, and adverse effects.

46 This unfortunately led to severe adverse effects.

47 n cancer immunotherapies and their potential adverse effects.

48 on that is experiencing long-term multiorgan adverse effects.

49 eradication of the microorganism and without adverse effects.

50 All medications have adverse effects.

51 reat pain while avoiding central and cardiac adverse effects.

52 marginally effective, costly, and some have adverse effects.

53 des in several mouse strains without causing adverse effects.

54 ifficult, 5 = easy]) and was without serious adverse effects.

55 There were no treatment-related adverse effects.

56 Unfortunately, adverse effects accompany every pharmacologic interventi

57 hether the high frequency of reported statin adverse effects (AEs) may be associated with the nocebo

58 Observational studies have suggested several adverse effects after long-term PPI, but these findings

59 To 14-month follow-up, the most frequent adverse effects among 173 patients were headache (61 [35

60 lucocorticoids are associated with important adverse effects and a substantial proportion of patients

61 nly partially effective, carry dose-limiting adverse effects and are potentially addictive, highlight

62 f infection, they suffer from having serious adverse effects and are unable to abolish the virus from

63 ease, as they may be associated with serious adverse effects and as-yet-unknown long-term consequence

64 depth, and photophobia score; however, local adverse effects and blurring were higher in the group re

65 clusion criteria, dose optimization, risk of adverse effects and drug interactions, and verification

66 , substantial concern exists about potential adverse effects and efficacious readmission-reduction st

67 nd 95% CIs of all-grade and high-grade (>=3) adverse effects and evaluated the within-study heterogen

68 delivering effective treatments and avoiding adverse effects and financial toxicity caused by innovat

69 t FN3-PARs can suppress tumor growth with no adverse effects and FN3-PARs reduced immunosuppressive p

70 gement of several pegasparaginase-associated adverse effects and guide whether and how to continue th

71 scribed in hospitals, increasing the risk of adverse effects and imposing unnecessary costs in health

72 for complications is necessary to limit any adverse effects and improve visual and surgical outcomes

73 ntal marriage can substantially buffer these adverse effects and might form a basis for prevention ef

74 ts activation is also associated with marked adverse effects and novel modes of PPARgamma modulation

75 oid analgesics use, as they have significant adverse effects and opioid prescription rates have reach

76 as interindividual differences in efficacy, adverse effects and resistance to therapy.

77 ved therapy, it is associated with potential adverse effects, and all other clinical interventions ar

78 he infusion, staff training on management of adverse effects, and attention to safety precautions.

79 occi (VRE) colonization after receiving OVP, adverse effects, and cost of OVP.

80 paper will review the cardiovascular impact, adverse effects, and possible mechanisms of action of ph

81 in blood pressure, frailty, quality of life, adverse effects, and serious adverse events.

82 erse events, adverse events, dropouts due to adverse effects, and treatment adherence.

83 s, yet the underlying mechanisms for such an adverse effect are not well understood.

84 These adverse effects are corrected by heating the immersion o

85 Adverse effects are discussed and imaging follow-up regi

86 nse of ICB remain poor; furthermore, cardiac adverse effects are emerging, which impact several mecha

87 Device-related adverse effects are less with the 2-lead system.

88 tent post-treatment urinary, bowel or sexual adverse effects are likely to increase this risk.

89 However, the mechanisms underlying these adverse effects are not fully understood.

90 isms of targeted therapies and knowing their adverse effects are vital to imaging assessment and ensu

91 on, could provide better outcomes with fewer adverse effects, as could combinations with chemotherapi

92 Skeletal myopathy is a known statin-induced adverse effect associated with mitochondrial changes.

93 ent (irAE) that further expands the range of adverse effects associated with checkpoint inhibitor the

94 hese actions of CsA likely contribute to the adverse effects associated with its clinical application

95 However, most of the adverse effects associated with opioid therapeutics are

96 are of increasing global concern because of adverse effects associated with the release of bioactive

97 ucted to determine whether BPAR mediated the adverse effects between ethnicity and outcomes.

98 was a significant difference in the rate of adverse effects between real-time ultrasound-guided (0.6

99 Mexiletine 0.1 and 0.5 uM had no adverse effects, but did not reduce VF incidence.

100 g-term use of oral corticosteroids has known adverse effects, but the risk from brief oral steroid bu

101 are treatable and reversible; however, some adverse effects can be severe and lead to permanent diso

102 ity, specificity, preterm delivery, maternal adverse effects, congenital birth defects, childhood can

103 atient-driven priorities regarding potential adverse effects, costs, and expected benefit of differen

104 These diverse adverse effects could be attributed to inhibition of nic

105 oduction volume was associated with stronger adverse effect estimates.

106 e first decade postpartum and this window of adverse effect extends over two decades in women with la

107 nterferes with sleep and causes fatigue with adverse effects for nurses' and midwives' health, as wel

108 are key to determining the full magnitude of adverse effects from contaminant exposure in early life.

109 Observations indicating adverse effects from excess folic acid intake, elevated

110 surgery, concerns have been raised regarding adverse effects from GC, thereby necessitating a better

111 lapse, high rates of long-term morbidity and adverse effects from the available medications.

112 Despite their notorious adverse effects, glucocorticoids (GC, potent anti-inflam

113 people living in poverty buffer against the adverse effects higher economic inequality imposes on th

114 ell tolerated and has relatively few serious adverse effects, however interactions with other medicat

115 these antibodies show only minor, manageable adverse effects in humans, they offer a new therapeutic

116 bled proof-of-principle transfusions without adverse effects in humans.

117 wake in rodents and engendered dose-limiting adverse effects in NHPs.

118 se benefits and summarizes the literature on adverse effects in patients with CKD and T2D at risk for

119 to reduce cardiovascular events with limited adverse effects in this vulnerable group.

120 ides maximal reporter induction with minimal adverse effects in vivo.

121 umber of promising therapeutic benefits, but adverse effects, in particular emesis and nausea, have c

122 Long-term adverse effects included cognitive complaints and fatigu

123 conditions; however, they can cause various adverse effects including a negative impact on cognitive

124 In normal monkeys, type I causes many adverse effects including animal death.

125 ibiotics place patients at increased risk of adverse effects (including Clostridioides difficile diar

126 We highlight some of these adverse effects, including whole-body endocrinology and

127 way have been implicated as mediators of the adverse effects induced by gadolinium-based contrast age

128 t rest and under stress and the symptoms and adverse effects induced by the drug.

129 raocular pressure lowering experienced these adverse effects just few minutes after subconjunctival i

130 below the current developmental no observed adverse effect level (NOAEL) via drinking water, or drin

131 eliorated with AA139, and the 'no observable adverse effect level' (NOAEL) dose in mice is ~10-fold g

132 difficile infection, and antibiotic-related adverse effects necessitating change in therapy.

133 ed testosterone should be considered against adverse effects, notably increased prostate cancer and h

134 rs, which are devoid of the neuropsychiatric adverse effects observed with brain-penetrant CB1R block

135 imited supply, cost and potential for severe adverse effects observed with the blood derived rabies i

136 Glucocorticoids are effective, but adverse effects occur in a high proportion of patients.

137 ted serious adverse events occurred, and few adverse effects occurred after in-community treatment wi

138 Medication adverse effects occurred in 43% (92 of 212) of participa

139 k as interconnected pathways, leading to the adverse effect of a postpartum diagnosis.

140 The adverse effect of climate change continues to expand, an

141 LTD induction harder, thereby preventing the adverse effect of excessive LTD on memory consolidation.

142 Infections are an important adverse effect of immunosuppression for treatment of inf

143 contrast, linear MR analyses demonstrated an adverse effect of increasing DBP increments on CVD outco

144 enetic changes to the INSR might mediate the adverse effect of prenatal famine exposure on WC in adul

145 ins content, and dark-drying can nullify the adverse effect of SaLV on crocins content.

146 There is an apprehension of the adverse effect of such detergents on various living orga

147 nd provide practical methods to mitigate the adverse effect of TBs on the performance of these alloys

148 ed in one patient, and there was no observed adverse effect of the additional sedatives used.

149 Our report describes the adverse effect of Triplixam, probably resulting from its

150 other physicians to be aware of the possible adverse effect of Triplixam.

151 d reflect adaptive membrane remodeling or an adverse effect of VLCFA dysfunction.

152 ynamics can simulate some the beneficial and adverse effects of acute exercise.

153 Although adverse effects of AgNPs on aquatic organisms have been

154 The adverse effects of ambient particulate matter (PM) on hu

155 targets for drug development in treating the adverse effects of Bic.

156 The increasing awareness of the adverse effects of both strong and weak respiratory effo

157 Adverse effects of breast cancer treatment can negativel

158 Accordingly, adverse effects of cancer therapies that interfere with

159 pathy is among the most common dose-limiting adverse effects of cancer treatment, leading to dose red

160 In addition, the potential adverse effects of CAR T cells highlight the need for me

161 t systematic review and meta-analysis of the adverse effects of CBD across all medical indications.

162 ty, and heterogeneous responses appearing as adverse effects of checkpoint inhibitor treatments.

163 logeneic islet transplantation is limited by adverse effects of chronic immunosuppression used to con

164 Many studies have estimated the adverse effects of climate change on crop yields, howeve

165 Understanding adverse effects of contemporary treatment approaches for

166 We show that bladderwort traps avoid the adverse effects of creeping flow by generating strong, f

167 Adverse effects of DBS were examined with a structured i

168 hat the gut microbiota may contribute to the adverse effects of DEHP on the host by altering metaboli

169 drins are proteins that help to mitigate the adverse effects of dehydration.

170 s an important role in defining response and adverse effects of drugs.

171 ng in part to structural differences of NRs, adverse effects of EDCs vary significantly among species

172 tic stress tolerance and explain some of the adverse effects of elevated cytokinin action on plant de

173 While the adverse effects of elevated salinity levels on leaf gas

174 he unpleasant gynecologic and nongynecologic adverse effects of estrogen treatment, the development o

175 However, there are concerns of potential adverse effects of excess folic acid intake and/or eleva

176 ide and that include efforts to mitigate the adverse effects of exposure to suicide attempt on subseq

177 serious concerns regarding the toxicity and adverse effects of fluorinated processing aids on humans

178 xposing nontarget animals to greater risk of adverse effects of GBHs in natural and agricultural envi

179 inhibiting HbS polymerization and downstream adverse effects of hemolytic anemia and vaso-occlusion.

180 k utilizes intestinal bacteria to offset the adverse effects of high fat diets, C57BL/6J mice were fe

181 We also show adverse effects of higher testosterone on breast and end

182 on factor (TF) that mediates protection from adverse effects of hypertonicity by increasing transcrip

183 The study therefore provided no evidence for adverse effects of intensive breeding on the contents of

184 ncy also raises concerns about the potential adverse effects of iron excess.

185 The most common adverse effects of isradipine were edema and dizziness.

186 ies were evaluated for dosing, outcomes, and adverse effects of ketamine.

187 warranted to consider tradeoffs between the adverse effects of lead on human health and the importan

188 ning and treatment for the prevention of the adverse effects of malaria infection in pregnancy in the

189 hypothesis that cytokines contribute to the adverse effects of MIA on children.

190 However, the adverse effects of mixed shifts on perceptions of staffi

191 Here, to reduce the adverse effects of multiple drug combinations and improv

192 pathy and small-intestinal ulcers are common adverse effects of nonsteroidal anti-inflammatory drugs

193 re not sufficient to prevent and improve the adverse effects of obesity, thus novel interventions are

194 c function, relieving jaundice, and reducing adverse effects of obstruction.

195 me platform not only has potential to reduce adverse effects of orally delivered antimicrobials, but

196 re of penicillin allergy label carriage, the adverse effects of penicillin allergy labels, and curren

197 ed to maximize the benefits and minimize the adverse effects of pharmaceutical agents for NAFLD.

198 otoxicity testing is critical for predicting adverse effects of pharmaceutical, industrial, and envir

199 ount of environmental concerns, the fate and adverse effects of plastics have attracted considerable

200 support and early monitoring to prevent the adverse effects of poor sleep.

201 uld evaluate the long-term effectiveness and adverse effects of prophylaxis.

202 To reduce adverse effects of proton radiotherapy, a model of cogni

203 e yet to be developed, and thus the specific adverse effects of ROS1 inhibition cannot be deconvolute

204 ate gum (G), as well as to rule out possible adverse effects of some of its components.

205 g survivors of HL regarding the psychosocial adverse effects of the cancer experience.

206 ribute to the understanding of the potential adverse effects of the highest doses of exercise trainin

207 We also summarized the Gl and liver adverse effects of the most commonly utilized medication

208 protect human and environmental health from adverse effects of the toxic element mercury and its com

209 ombocytopenia (ITP) must be balanced against adverse effects of therapies.

210 g VLP diets with BCAA temporarily annuls the adverse effects of these diets on growth, which is linke

211 arasites, but there was no evidence that the adverse effects of these parasites are exacerbated by an

212 sure; reduction of childhood blood pressure; adverse effects of treatments.

213 ic structures is a common method of tackling adverse effects of turbidity currents.

214 ate depression-like behavior and reverse the adverse effects of unpredictable chronic mild stress.

215 Given the potential health benefits (and adverse effects), of polyphenolic and steroidal glycoalk

216 After 14 days, no evidence of adverse effect on body weight, mortality and clinical si

217 eiving much less attention despite anaemia's adverse effect on health, wellbeing, and economic produc

218 fferent stages of differentiation and has no adverse effect on human skeletal cell growth and behavio

219 and increased systemic inflammation have an adverse effect on infant birth weight.

220 FFR-guided heart rate settings had no adverse effect on LV structure or function, whereas conv

221 ore admission to a critical care unit has an adverse effect on patient outcomes and is often due to t

222 Mechanistically, GM-CSF had no adverse effect on regulatory T-cell reconstitution, but

223 E449K has no adverse effect on the competence of Int for attP x attB

224 HDAC10 deletion had no adverse effect on the health of mice, which retained nor

225 There was no adverse effect on transplant rates and no differential e

226 oncentrations were well tolerated without an adverse effect on vision-related quality of life.

227 e ethanol consumption has distinct toxic and adverse effects on a variety of tissues.

228 id and, when given intravenously, have fewer adverse effects on acid-base balance.

229 tine 1 uM reduced VF incidence to 0% but had adverse effects on atrioventricular conduction and ventr

230 subsequent deposition to land surface exert adverse effects on biogeochemical nitrogen (N) cycling.

231 tilage-degrading proteinases and to minimize adverse effects on bone and possibly other tissues.

232 roscopic infections, and are thought to have adverse effects on both mothers' and newborns' health.

233 servational studies have suggested potential adverse effects on cancer risk, birth outcomes, and othe

234 uctions in rainfall are likely to have acute adverse effects on child nutritional status.

235 our bed boost was associated with persistent adverse effects on cosmetic status and arm and shoulder

236 one mineral density, and decreased body fat; adverse effects on decreased HDL, and increased risks of

237 long-term exposure to flexibility could have adverse effects on duty-hour violations, resident satisf

238 efficient retrograde transport with minimal adverse effects on endogenous transport.

239 These models showed adverse effects on ESs in spiked soils, depicted as chan

240 s in the unirradiated neck without long-term adverse effects on global QOL.

241 ficantly decreased spermidine levels with no adverse effects on growth.

242 Poor sleep behavior appears to have adverse effects on health by metabolic disruption and im

243 to flame retardants (FRs) is associated with adverse effects on human health.

244 e corresponding Hazard Quotient indicated no adverse effects on human health.

245 ributor to poor air quality, has an array of adverse effects on human, animal, and plant health.

246 and antiretroviral therapy in utero may have adverse effects on infant growth.

247 of stem cell transplant populations, with no adverse effects on key regenerative parameters.

248 t cortical development and have long-lasting adverse effects on neurodevelopmental outcome.

249 d less restrictive management appear to have adverse effects on panda protection.

250 anel size was associated with no or modestly adverse effects on patient-centered and effective care.

251 g, alone and in combination have significant adverse effects on pumping capacity, contribute to irrev

252 programming effects in the offspring without adverse effects on spawning quality.

253 ve negative environmental impacts, including adverse effects on species and ecosystems through habita

254 otential (PCB-bioaccumulation reduction) and adverse effects on the benthic invertebrates Chironomus

255 doses, raising the concern of light-induced adverse effects on the biology under study.

256 hes for breast cancer patients that minimize adverse effects on the brain.

257 erm infant, but evidence suggests off-target adverse effects on the developing cardiovascular system.

258 rostructures, in a reversible manner without adverse effects on the electrical properties.

259 icals present in the environment, those with adverse effects on the endocrine system are referred to

260 nistic studies showed that SNCA mutation has adverse effects on the nucleus by trapping Ras-related n

261 Psychological stress has adverse effects on various human diseases, including tho

262 lion individuals annually, with considerable adverse effects on wellbeing and socioeconomic developme

263 cants; PCB exposure has been associated with adverse effects on wildlife and humans.

264 schaemia were contrasted with its concurrent adverse effects (on several variables) in the same heart

265 These errors may result in adverse effects or viral resistance, limiting future tre

266 who could not tolerate the drugs, had early adverse effects, or reported few immediate benefits.

267 een the two protocols regarding the reported adverse effects (P > 0.05).

268 have high analgesic potency and low risk of adverse effects, particularly no abuse liability.

269 n its potent in vitro activity and favorable adverse effect profile.

270 suggests that type I and especially the less adverse effect-prone type III IFN are good candidates fo

271 significant differences in CRT reduction or adverse effect rates.

272 mechanisms of ketamine's anti-depressant and adverse effects remain poorly understood.

273 Other adverse effects reported with ADHD stimulants included a

274 nt that include the alleviation of long-term adverse effects require a deeper understanding of the ge

275 Since the NTS1 receptor has been linked to adverse effects, selective MOR-NTS2 ligands are preferre

276 cer pain, use of oxycodone imposes a risk of adverse effects such as addiction, overdose, and death.

277 it lacks specificity and imposes unintended adverse effects such as opportunistic infections and mal

278 tumour staging and potentially reducing late adverse effects such as secondary malignancy compared wi

279 tikinase inhibitors, patients had off-target adverse effects, such as hypertension, rash, and diarrhe

280 is well tolerated by most patients, however adverse effects, such as hyponatraemia and water intoxic

281 liarozole and talarozole) tend to have fewer adverse effects than traditional retinoids but lack targ

282 these new treatments are accompanied by new adverse effects that radiologists need to know.

283 ts much shorter reported half-life; however, adverse effects toward the placenta appear to have compo

284 e findings is challenging owing to potential adverse effects, unclear mechanisms of action and a lack

285 y to completely finish bowel preparation and adverse effects (unpleasant taste, nausea, and vomiting)

286 tential novel CVD drug targets without these adverse effects, we perform genome-wide analyses of part

287 ify susceptibility genes for lithium-induced adverse effects, we performed a genome-wide association

288 No vaccine-related serious adverse effects were found in the dose-ranging study in

289 No harm or adverse effects were found.

290 Adverse effects were limited to those induced by its kno

291 Cenegermin was well tolerated; adverse effects were mostly local, mild, and transient.

292 The rates of reported adverse effects were not different (colchicine 23.0% ver

293 The adverse effects were not explained by styrene monomers l

294 No adverse effects were observed in the nanoparticle-treate

295 Long-term adverse effects were rare, except for B-cell depletion a

296 ffect (partial eta squared eta(2) = .05); no adverse effects were reported.

297 Transient procedural adverse effects were seen, but no cell-related adverse e

298 ed pericardial effusion and gastrointestinal adverse effects were similar in both groups.

299 dified PDMS was biocompatible, displaying no adverse effects when used in a simple liver-on-a-chip mo

300 etal muscle contractility while avoiding the adverse effects with betaAR agonists.