ライフサイエンスコーパス: aetiology

1 seases, the majority of which have a genetic aetiology.

2 x genetic patterns in cardiovascular disease aetiology.

3 rome, characterized by a complex polygenetic aetiology.

4 is thought to reflect a common environmental aetiology.

5 as suggest a shared UV-independent molecular aetiology.

6 derable ethnic differences in prevalence and aetiology.

7 commonly used to treat diseases of metabolic aetiology.

8 nvironment in a new understanding of disease aetiology.

9 one phenotype is attributable to one single aetiology.

10 is a key factor in mood and anxiety disorder aetiology.

11 n pattern among patients with embolic stroke aetiology.

12 n parents and siblings, to shed new light on aetiology.

13 tricular function, suggesting shared genetic aetiology.

14 in unknown, but may reflect a shared genetic aetiology.

15 eatment; few studies have yet to explore its aetiology.

16 ortant clues for future research into asthma aetiology.

17 tigations were in favour of a post-traumatic aetiology.

18 een suggested that there is an immunological aetiology.

19 -8-unrelated PEL-like lymphomas with unknown aetiology.

20 he limited understanding of its multifaceted aetiology.

21 critical role of the CDKN2 locus in BCP-ALL aetiology.

22 , as well as mutational processes of unknown aetiology.

23 d PPIL3 at 2q33 in ER-negative breast cancer aetiology.

24 mproving the understanding of thyroid cancer aetiology.

25 rating cardiac function, has a heterogeneous aetiology.

26 and keloids (n = 12) resulting from various aetiology.

27 ffirmed the importance of this process in PD aetiology.

28 ) strongly implicate mitochondria in disease aetiology.

29 matic brain injury but has been of uncertain aetiology.

30 ron dysregulation in the Alzheimer's disease aetiology.

31 n (FGR) with and without villitis of unknown aetiology.

32 dioembolism (CE), and stroke of undetermined aetiology.

33 ies of ischaemic, haemorrhagic and traumatic aetiology.

34 on-suicidal self-harm share a common genetic aetiology.

35 odegenerative disorder with a multifactorial aetiology.

36 disorder that potentially involves multiple aetiologies.

37 re of schizophrenia and suggest differential aetiologies.

38 le contributors and perhaps several distinct aetiologies.

39 erves in patients with neuropathy of various aetiologies.

40 existence of vaccines against many of their aetiologies.

41 t, or are distinct behaviours with different aetiologies.

42 havioural syndrome produced by these diverse aetiologies.

43 a to discriminate CLIPPERS from non-CLIPPERS aetiologies.

44 g hundreds of traits for overlapping genetic aetiologies.

45 read, suggesting the possibility of distinct aetiologies.

46 s of all ages, with a wide range of possible aetiologies.

47 , and encompass both monogenic and polygenic aetiologies.

48 iety of possible underlying risk factors and aetiologies.

49 However, beyond these well-known aetiologies, a range of other movement disorder syndrome

50 ovarian cancer overall and suggests distinct aetiologies across histotypes.

51 hronic inflammatory bowel disease of unknown aetiology affecting the colon and rectum.

52 s treatments has been stymied by the unknown aetiology, although recent advancements suggest a potent

53 oved access to diagnostics, to better define aetiologies and develop novel diagnostic tools and treat

54 man RTT severity, reveals compound molecular aetiologies and provides a valuable resource in the sear

55 an genetics, which are to understand disease aetiology and aid in disease screening, diagnosis, progn

56 (ASD) is a complex disorder with an unclear aetiology and an estimated global prevalence of 1%.

57 980, with a focus on regional differences in aetiology and antimicrobial resistance (AMR) in the past

58 on available information regarding microbial aetiology and antimicrobial susceptibility, but sub-Saha

59 ny epileptic encephalopathies have a genetic aetiology and are often associated with de novo mutation

60 arre syndrome, as many will have a metabolic aetiology and be potentially treatable.

61 Ischaemic heart disease has a multifactorial aetiology and can be prevented from developing in popula

62 The heterogeneous aetiology and clinical presentation of DCM make a correc

63 (MODY), we sequenced MODY cases with unknown aetiology and compared variant frequencies to large publ

64 nction in skeletal muscle contributes to the aetiology and development of muscle diseases and metabol

65 wed the literature on clinical presentation, aetiology and diagnostic approaches for the main MCD sub

66 primary polydipsia depends on the underlying aetiology and differs in central DI, nephrogenic DI and

67 esses of human GWAS in understanding disease aetiology and identifying potential drug targets, microb

68 rbidities of ADHD, as commonalities in their aetiology and management may lead to novel pharmacologic

69 wledge has provided immense insight into the aetiology and mechanisms of kidney diseases but raises e

70 However, many aspects of its aetiology and molecular mechanisms remain unknown.

71 ises to provide renewed understanding of the aetiology and pathogenesis of age related neurodegenerat

72 We do not fully understand AD aetiology and pathogenesis, but oxidative damage is a ke

73 aki disease, focusing on their epidemiology, aetiology and pathophysiological mechanisms.

74 en and adults, but differences in underlying aetiology and pharmacodynamics might differentially affe

75 patterns differ significantly with dystonia aetiology and phenotype.

76 xpansions contribute strongly to the genetic aetiology and phenotypic complexity of ASD.

77 offer unique opportunities to understand the aetiology and possible treatment of synovial joint disea

78 In this review, we summarise the anatomy, aetiology and presentation of posterior circulation stro

79 Inflammation plays a key role in the aetiology and progression of Alzheimer's disease (AD).

80 These findings may be relevant to the aetiology and treatment of diverse neurological and psyc

81 self-report, provides novel insights into RD aetiology and underlying pathological pathways.

82 study sheds new light on mutant aaRS disease aetiologies, and explains how aaRS sequestration of unch

83 case-control study that measured the burden, aetiology, and consequences of moderate-to-severe diarrh

84 burden, few data are available on incidence, aetiology, and outcomes, particularly regarding impairme

85 er Study (GEMS) has described the incidence, aetiology, and sequelae of medically attended moderate-t

86 atients with a known or later proven genetic aetiology, and subsequently felt to be part of the pheno

87 the factor structure of spatial anxiety, its aetiology, and the origins of its association with gener

88 ogy; (iii) suspected non-Alzheimer's disease aetiology; and (iv) healthy ageing.

89 neurological disorders, but their molecular aetiologies are incompletely characterised.

90 delineate the spectrum of movement disorder aetiologies associated with SIBs.

91 c profile scoring to test for shared genetic aetiology between cognitive functions and neuropsychiatr

92 Evidence for shared genetic aetiology between NSSH and suicide attempt was not stati

93 w up regressions identified a shared genetic aetiology between NSSH and suicide thoughts, and between

94 nalyses were used to test for shared genetic aetiology between tiredness and up to 29 physical and me

95 alysis indicated considerable shared genetic aetiology between trail making, general cognitive functi

96 NFSF10 gene may be involved in breast cancer aetiology, but further functional experiments are needed

97 ome and are differentiated from non-CLIPPERS aetiologies by neuroradiological and neuropathological f

98 and HG suggest a placental component to the aetiology by implicating common variants in genes encodi

99 ed between 2004 to 2015, in order to analyse aetiology, clinical presentation, spectrum of pathogens,

100 ated with cancer, but in many cases multiple aetiologies coexist in an individual patient.

101 rtality rate to construct the Bronchiectasis Aetiology Comorbidity Index (BACI).

102 evealed that genomic disorders and monogenic aetiologies contribute meaningfully to seemingly complex

103 Regardless of the underlying aetiology, couples require accurate information on their

104 ation classification: underpinning research; aetiology; detection and diagnosis; treatment developmen

105 New studies on aetiology, diagnosis, management and treatment are under

106 to several mutational signatures of unknown aetiology directly associates with the level of hypoxia,

107 Author consensus on aetiology divided into, 'probably functional (n=35.71%),

108 ncephaly individuals with a probable genetic aetiology do not have a genetic diagnosis.

109 An improved aetiology-driven personalized approach to clinical care

110 Here, we identify the aetiology driving AI in mice carrying a p.S55I mutation

111 c structural brain changes and heterogeneous aetiologies (eg, autoimmune and drug-induced).

112 ide ranging functions, are implicated in its aetiology, especially in those with therapy-resistant se

113 Therefore, non-PTEN aetiologies exist in PTEN wildtype patients.

114 We collate evidence for different proposed aetiologies: fluctuating cognition as an attentional dis

115 Identifying a common aetiology for AI resulting from mutations in two differe

116 findings demonstrate a common shared genetic aetiology for CHD and renal anomalies, indicating that C

117 gs open new questions as to what is the true aetiology for FSHD, the epigenetic events associated wit

118 ategorised 11 (85%) on the basis of probable aetiology (functional vs structural) in agreement with c

119 This approach to cancer aetiology has also incriminated various endogenous, enzy

120 alpha-synuclein (alphaSyn; SNCA) in disease aetiology has been proposed based on genetics and neurop

121 ng RAIDs, and limited understanding of their aetiology has made repurposing drugs for RAIDs challengi

122 admission rates for encephalitis of unknown aetiology have increased by 37% since the introduction o

123 Admissions with a specified viral aetiology have increased since 2000.

124 he 166 samples adjudicated to have no sepsis aetiology identified by any of the tested methods, seque

125 (ii) mixed Alzheimer's disease and vascular aetiology; (iii) suspected non-Alzheimer's disease aetio

126 ly differentiate between bacterial and viral aetiologies, implementation of antimicrobial stewardship

127 ears and admission rate trends for specified aetiologies in relation to introduction of PCR testing a

128 Data on asthma aetiology in Africa are scarce.

129 proaching 1000 patients with a known genetic aetiology in the UK Parkinson's disease population.

130 Aetiology included 59% IgE-mediated anaphylaxis, 2% non-

131 jury and to chronic kidney disease of varied aetiologies, including diabetic kidney disease, focal se

132 netic forms of DCM can result from different aetiologies, including inflammation of the myocardium du

133 us, age at last menstruation, and menopausal aetiology) information available.

134 Since MSD and LSD have similar aetiologies, interventions targeting rotavirus, Shigella

135 iduals, nephrolithiasis has a multifactorial aetiology involving genetic and environmental factors.

136 Immunosuppression of unknown aetiology is a hallmark feature of glioblastoma and is c

137 The correct aetiology is Gbb lymphocryptovirus 1.

138 application to understanding common disease aetiology is limited.

139 r approximately 10% of births worldwide; the aetiology is multifactorial with intra-amniotic infectio

140 f end-stage renal disease, but their genetic aetiology is not well understood.

141 mproved understanding of childhood pneumonia aetiology is required to inform prevention and treatment

142 However, our understanding of its aetiology is still incomplete.

143 believed to be an acquired disorder, but its aetiology is unknown.

144 ion), but whether they have a shared genetic aetiology is unknown.

145 hought to have a significant role in disease aetiology is Zn(2+) homeostasis, which is disrupted in t

146 Significant heterogeneity across aetiologies, neurobiology and clinical phenotypes have b

147 ur in MS and describe the clinical symptoms, aetiology, neuroimaging findings and management strategi

148 However, MCI is an aetiology-neutral description, which therefore includes

149 h lower gastrointestinal bleeding of various aetiologies; nevertheless, its role in UC-related acute

150 l changes and mutation signatures of unknown aetiology, not previously identified in melanoma.

151 our findings in other cohorts and with other aetiologies of AKI.

152 Aetiologies of camptocormia are heterogeneous, and Parki

153 ater dietary exposures when studying dietary aetiologies of diseases postulated to have developmental

154 zoonotic transmission and adds to the known aetiologies of infectious diseases for this region.

155 sis of DILI relies on the exclusion of other aetiologies of liver disease as specific biomarkers are

156 combined study of genetic and environmental aetiologies of severe mental disorders.

157 There are many potential aetiologies of spine pain with similar clinical presenta

158 Both vascular and neurological aetiologies of this pain have been suggested but remain

159 tia with Lewy bodies (DLB) is the underlying aetiology of 10-15% of all cases of dementia and as such

160 These results contribute to elucidating the aetiology of a long-known yet poorly understood phenomen

161 microRNAs (miRNAs) has been linked with the aetiology of a number of retinal dystrophies.

162 omaviruses (HPVs) has been implicated in the aetiology of a variety of cancers.

163 The role of ambient temperature in the aetiology of acute scrotal pain (ASP) remains uncertain.

164 inflammatory processes are important in the aetiology of AD, we have now analysed the correlation of

165 zed that these PUFAs may be important in the aetiology of allergic diseases.

166 esults increase our understanding of genetic aetiology of ALS.Amyotrophic lateral sclerosis (ALS) is

167 e of aggregation and plaque formation in the aetiology of Alzheimer's disease (AD) is subject to deba

168 Although the aetiology of amyotrophic lateral sclerosis (ALS) remains

169 as ASD risk genes, suggesting the universal aetiology of ASD for these genes.

170 egulatory genomic variation in the molecular aetiology of ASD, we quantified genome-wide patterns of

171 pporting a developmental contribution to the aetiology of atopic eczema and pointing to potentially m

172 y twin and sibling studies to understand the aetiology of atopic march diseases.

173 on mechanism for axon growth, and reveal the aetiology of axon-guidance defects in sax-3/Robo and vab

174 lying BD and provide novel insights into the aetiology of BD.

175 However, the genetic aetiology of broad sense (non-suicidal and suicidal) sel

176 Underlying aetiology of bronchiectasis, as well as treatment and ri

177 ment of trimethylamine N-oxide (TMAO) in the aetiology of cardiometabolic diseases and chronic kidney

178 The aetiology of CD is complex, with contributions of both g

179 apillomaviruses (HPVs) are implicated in the aetiology of cervical cancer.

180 environmental influences, play roles in the aetiology of CHD.

181 sought to compare their causal roles in the aetiology of CHD.

182 We aimed to describe the incidence and aetiology of cirrhosis in the Halland region from 2011 t

183 Our results elucidate the aetiology of CMCS and highlight a new molecular role for

184 ur understanding of the role of genes in the aetiology of complex disease, the molecular underpinning

185 Diet is strongly associated with the aetiology of Crohn's Disease (CD) and exclusive enteral

186 The aetiology of Crohn's disease is complex and may include

187 biomarkers and provide new knowledge on the aetiology of CVID.

188 cause multiple factors are implicated in the aetiology of delirium, there are likely several neurobio

189 results suggest possible differences in the aetiology of depression between women and men.

190 lammation are thought to be prominent in the aetiology of depression.

191 the functional TLR2-system was suggested in aetiology of depressive, anxious and anorexiolytic sympt

192 gs have led to new efforts to understand the aetiology of diabetic neuropathy, along with new 2017 re

193 The aetiology of diabetic retinopathy (DR), the leading caus

194 tterns becomes particularly important in the aetiology of different diseases including cancers.

195 n of beta-dystroglycan as a key event in the aetiology of Duchenne muscular dystrophy.

196 g resources can be utilized to elucidate the aetiology of early-onset CRC and inform the development

197 Much-needed research to establish the aetiology of FND will enhance clinical care and communic

198 To understand the genetic aetiology of Fuchs endothelial corneal dystrophy (FECD),

199 The aetiology of gambling disorder is complex, with implicat

200 Although the aetiology of GD remains unknown, evidence indicates a st

201 will focus on recent advances in the genetic aetiology of glycaemic traits, and the resulting biologi

202 nrichment analysis implicated the CNS in the aetiology of handedness.

203 n is an important tool for understanding the aetiology of human disease.

204 le played by high levels of aluminium in the aetiology of human neurodegenerative and neurodevelopmen

205 se genetic findings provide insight into the aetiology of human NOA/SO and pave the way for further f

206 The aetiology of IBD is partly attributed to a deregulated i

207 r gene has previously been implicated in the aetiology of increased suicidal risk in non-HIV infected

208 e oxygen species (ROS) are implicated in the aetiology of interstitial lung disease (ILD).

209 The aetiology of intervertebral disc (IVD) degeneration rema

210 at the following have important roles in the aetiology of kidney stones: transporters and channels; i

211 an integral role for satellite cells in the aetiology of lean tissue recovery following a severe bur

212 ts in the C57BL/6 mouse and investigated the aetiology of low CD4 T-cell counts.

213 bacter pylori infection is implicated in the aetiology of many diseases.

214 iation in the HLA region is important to the aetiology of many disorders, it does not appear to be hi

215 d, therefore, they are not homologous in the aetiology of metabolic disease.

216 dence for a role of T cell regulation in the aetiology of mouth ulcers.

217 s risk factors has grown over the years, the aetiology of multiple sclerosis has still not been fully

218 of exposure to environmental factors in the aetiology of multiple sclerosis.

219 to advancing the study of the physiology and aetiology of neurological disorders, and to the developm

220 omatic inhibition is thought to underlie the aetiology of neurological dysfunction in seizures, autis

221 entation, are believed to be involved in the aetiology of obesity and diabetes.

222 facilitate our understanding of the complex aetiology of ocular coloboma.

223 CH1 pathway which has been implicated in the aetiology of other neurodegenerative disorders including

224 The aetiology of paucigranulocytic asthma is unknown.

225 n of emotional perception is involved in the aetiology of psychosis.

226 role of the frontal and limbic areas in the aetiology of psychotic symptoms, in subjects without the

227 ur findings may provide new insight into the aetiology of PTB and improve our ability to predict and

228 ve implications for our understanding of the aetiology of PWS-related behavioural traits and translat

229 veal important insights into the complicated aetiology of rheumatic diseases.

230 As the aetiology of sarcoidosis is unknown, no specific treatme

231 ulated epigenetic variation in the molecular aetiology of schizophrenia, this study aimed to identify

232 nt advances that offer new insights into the aetiology of schizophrenia.

233 ld and arthropod proteins significant in the aetiology of sEA.

234 d requires elucidation for understanding the aetiology of secondary hyperparathyroidism in chronic ki

235 and schizophrenia likely play a role in the aetiology of self-harm using multivariate genetic design

236 on theory implicated these infections in the aetiology of several systemic diseases, ranging from art

237 Rotator cuff tears (RCT) are the common aetiology of shoulder pain.

238 enome-Wide Association Studies (GWAS) in the aetiology of sleep, mental health and metabolic disorder

239 A patients, raising the possibility that the aetiology of SMA is linked to RNA metabolism.

240 ci will facilitate understanding the genetic aetiology of smoking behaviour and may lead to the ident

241 red, developmental stage with respect to the aetiology of social support.

242 The aetiology of SUDEP is unclear.

243 ith morphological changes is involved in the aetiology of SUNCT and SUNA.

244 the parasegment boundaries and explains the aetiology of the even-skipped null mutant phenotype.

245 demonstrate low probability of a neoplastic aetiology of the examined pathologies in the Tyrannosaur

246 In the originally published article, the aetiology of the single case of B cell lymphoma found in

247 ate moderately with general anxiety, but the aetiology of their association remains unexplored.

248 ysteine levels that could participate in the aetiology of these diseases.

249 provides important insights into the genetic aetiology of this common craniofacial malformation.

250 all the connective tissue diseases, and the aetiology of this complex and heterogeneous condition re

251 unknown, precluding our understanding of the aetiology of this disease.

252 pendent of dose, patient characteristics, or aetiology of TIA or stroke.

253 rature is likely to be playing a role in the aetiology of TT and TA in Scotland but not EO.

254 with a causal role of BCAA metabolism in the aetiology of type 2 diabetes.

255 However, delineating the aetiology of UC is necessary to ultimately achieve disea

256 t roles in shaping food preferences; but the aetiology of variation in non-alcoholic beverage prefere

257 ite its widespread and damaging effects, the aetiology of WBD remains largely unresolved.

258 ase of the central nervous system (CNS), the aetiology of which is still unknown.

259 ost RDEB patients experience daily pain, the aetiology of which is unclear but may include inflammati

260 mitochondria, and may help to understand the aetiology of Zbtb11-associated intellectual disability.

261 to low barometric pressures exacerbates SCD aetiologies or impairs quality of life.

262 Stroke of undetermined aetiology or 'cryptogenic' stroke accounts for 30-40% of

263 all-vessel occlusion (SVO), other determined aetiologies (OTH), and undetermined aetiologies (UND).

264 ut we propose that a better understanding of aetiology, pathophysiology and symptomatic treatments ca

265 describe current insights into genetics and aetiology, pathophysiology, epidemiology, assessment, th

266 es mainly associated with non-immune disease aetiologies, poor longitudinal clinical-serological corr

267 se outbreak, and the circumstances for their aetiology, potentially influence the trajectory of trans

268 l framework with which to understand disease aetiology, progression, and heterogeneity and to target

269 cause substantial carer distress, but their aetiology remains elusive.

270 ommon and highly disabling disorder, but its aetiology remains enigmatic.

271 ing closure in the human embryo and coloboma aetiology remains poorly understood.

272 most common subgroup of paediatric ALL, its aetiology remains unknown.

273 principal component analysis across the two aetiologies revealed graded intra- and intergroup variat

274 ith cryptogenic stroke to identify potential aetiologies such as cardiac thrombi, cardiac tumours, ao

275 Despite the heterogeneity of aetiology, TDP-43 proteinopathy is a common pathological

276 Rheumatic diseases have complex aetiologies that are not fully understood, which makes t

277 h reduced ejection fraction as well as other aetiologies that have different treatment strategies.

278 e illness and systemic vasculitis of unknown aetiology that predominantly afflicts young children, ca

279 Due to its progressive nature and unclear aetiology the only treatment currently available is to e

280 ess made in our general understanding of BBS aetiology, the molecular and cellular mechanisms underly

281 The diagnosis of stroke, its underlying aetiology, theranostic strategies, recurrence risk and p

282 owing to wide variations in presentation and aetiology, thereby hampering timely and adequate managem

283 Although tSCI and DCM have different aetiologies, they show similar degrees of spinal cord pa

284 eed for an improved understanding of disease aetiology to inform the development of more efficacious

285 might be needed to delineate the underlying aetiology, together with a high index of suspicion for o

286 termined aetiologies (OTH), and undetermined aetiologies (UND).

287 included patients with hydrocephalus of any aetiology undergoing insertion of their first ventriculo

288 oups and thus have a role for clarifying the aetiologies underlying neurocognitive clinical syndromes

289 trophy in an effort to determine the genetic aetiology underlying neurodevelopmental disorders.

290 ed metabolic profiling may inform underlying aetiology via extensive associations with very-low-densi

291 qual incidence of malignant and inflammatory aetiologies was seen.

292 The most common aetiology was alcohol (50.5%), followed by cryptogenic c

293 The most common aetiology was squamous cell carcinoma and the majority o

294 epilepsy and other syndromes with different aetiologies, we propose that confirmation of a pathogeni

295 ute respiratory infection cases with unknown aetiology were associated with lower per-capita income.

296 ife exposure to tobacco smoke and rhinovirus aetiology were early-life risk factors for later asthma.

297 We report distinct aetiologies, which are clustered in five different categ

298 Global estimates of child mortality aetiologies, which are currently based on a single syndr

299 a RD, whereas the last four point to shared aetiologies with macular condition, myopia and glaucoma.

300 chitecture of the TMT and its shared genetic aetiology with other tests of cognitive function in 23 8