ライフサイエンスコーパス: affected sib-pair

1 model (DSM-IV OCD definite and probable; 50 affected sib pairs).

2 , CardiffCOGS, Cardiff F-Series, and Cardiff Affected Sib-Pairs).

3 sis incorporating 530 families and up to 736 affected sib pairs.

4 evaluated in an additional 140 families with affected sib pairs.

5 er loci and common diseases, with samples of affected sib pairs.

6 to small sets of affected relatives, such as affected sib pairs.

7 lysis methods in a group of Mexican American affected sib pairs.

8 Of 166 affected sib pairs, 30 (12 MZ, 17 DZ, and 1 of unknown z

9 at 19q13, with a sample size expanded to 139 affected sib pairs, along with 83 other affected relativ

10 Multipoint affected sib pair analysis identified seven regions with

11 Affected sib-pair analysis and parametric analysis with

12 In the case of affected sib-pair analysis without parents, the need for

13 Affected sib-pair analysis yielded multipoint maximum LO

14 Using affected sib-pair analysis, we obtained evidence suggest

15 point maximum LOD scores (MLS) obtained from affected-sib-pair analysis of all 345 families yielded s

16 Similarly, in affected-sib-pair analysis of our schizophrenia dataset

17 method when 50% of families consisted of an affected sib pair and one parent genotyped under an addi

18 For affected sib pairs and their parents, we found that inco

19 The study cohort comprised 2076 affected sib-pairs and 66 affected half-sib-pairs of the

20 row phenotype model (DSM-IV OCD definite; 41 affected sib pairs) and a broad phenotype model (DSM-IV

21 Affected sib pair (ASP) analysis has become common ever

22 score of 3.93 on chromosome 18, a two-point affected sib pair (ASP) LOD score of 3.11 on chromosome

23 er LD does not inflate type I error rates of affected sib pair (ASP) statistics in the whole paramete

24 del is unknown, "model free" methods-such as affected sib pair (ASP) tests-are often preferred over L

25 set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families.

26 f 18 markers on chromosome 21q, single-locus affected-sib-pair (ASP) analysis detected a high proport

27 f the one-dimensional, linear Ising model to affected-sib-pair (ASP) analysis in genetics.

28 The benefits and costs of stratification of affected-sib-pair (ASP) data were examined in three situ

29 ime, researchers are increasingly relying on affected-sib-pair (ASP) data.

30 librium test (TDT) has higher power than the affected-sib-pair (ASP) mean test when linkage disequili

31 When considering all possible affected sib pairs (ASPs) per nuclear family, we obtaine

32 ge to T1D in 187 and 356 families containing affected sib pairs (ASPs) yielded apparently conflicting

33 genotypes are available for unrelated cases, affected sib pairs (ASPs), or only one sibling per Asp.

34 ips, with parents, containing 97 independent affected sib pairs (ASPs), with follow-up in 49 addition

35 m nine geographical regions containing 2,658 affected sib-pairs (ASPs).

36 Morton's nonparametric affected-sib-pair "beta" model was used in the evaluatio

37 or multipoint model-free linkage analysis of affected sib pair data.

38 ed quantitative trait in the analysis, using affected-sib-pair data.

39 By expanding the traditional affected-sib-pair design to include unaffected and disco

40 in those methods (e.g., variance components, affected sib pair, extremely discordant sib pairs, etc.)

41 of chromosome regions to type 1 diabetes in affected sib pair families have revealed that the major

42 In a study of mainly paucibacillary leprosy-affected sib-pair families from South India, in addition

43 o fine mapping, linkage was evaluated in 385 affected sib-pair families using 13 evenly spaced polymo

44 alysis in families recruited on the basis of affected sib pairs for asthma reveal significant associa

45 vent reflecting the sampling scheme, such as affected sib pairs, for qualitative traits, or extreme d

46 type 2 diabetes susceptibility genes in 716 affected sib pairs from 477 Finnish families.

47 sample was comprised of 440 Mexican-American affected sib-pairs from 246 sibships.

48 nalysis in a Finnish sample comprised of 709 affected sib-pairs from 472 sibships.

49 ata showed no evidence of linkage, among 201 affected sib pairs, in the region of chromosome 2 that c

50 rmative for smaller pedigrees especially for affected sib pair kindreds.

51 A genome-wide scan (GWS) using affected sib pair linkage analysis was performed on 218

52 Affected sib-pair linkage analyses were performed on 98

53 diseases use three approaches: pedigree and affected sib-pair linkage studies and association studie

54 A genome-wide affected sib-pair linkage study with 221 Japanese famili

55 sociation study over the standard genomewide affected-sib-pair linkage analysis, for a range of diffe

56 this report, we have used a covariate-based affected-sib-pair linkage method to analyze the chromoso

57 sed nonparametric linkage (NPL) analysis and affected sib pair (MAPMAKER/SIBS) nonparametric methods

58 rily to allow the extension of the classical affected-sib-pair method to such populations.

59 r protein (APP) region is strongly linked to affected sib pairs of the oldest current age (i.e., age

60 om 67 keratoconus sib pair families with 110 affected sib pairs of white or Hispanic origin.

61 frequency of haplotype sharing was higher in affected sib pairs (p < 0.01).

62 We used three nonparametric affected-sib-pair programs and two nonparametric pedigre

63 tion of the two-locus LOD-score analysis for affected sib pairs proposed by Cordell et al.

64 Affected sib pairs showed excess allele sharing at the 1

65 Affected sib pair studies using a simple sequence repeat

66 e that the high proportion of twins found in affected-sib-pair studies can be adequately explained by

67 A genome-wide linkage scan in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD)

68 We focus on the affected sib-pair study design and develop test statisti

69 00009), and the affected-sib-pair test yielded a LOD score of 3.17 (P=.0

70 Here we show that the robustness of affected-sib-pair tests is related to the shape of the c

71 CARD15 mutation frequencies were greater in affected sib pairs than in sporadic CD cases but actuall

72 families to 364 ARM families with up to 329 affected sib pairs, the linkage signal on chromosome 9 v

73 For samples of 500 affected sib pairs, the tests are powerful in detection

74 information available through genotyping 118 affected sib pairs, their parents and other affected fam

75 ared the number of affected twin pairs among affected sib pairs to expected values in two separate sa

76 n traditional "model-free" tests such as the affected sib-pair, transmission/disequilibrium, haplotyp

77 Both the conditional analysis and the affected-sib-pair two-locus analysis provided further ev

78 nel of 225 ARM families comprising up to 212 affected sib pairs was genotyped for 386 markers.

79 onfigurations of affected relatives (such as affected sib pairs); we call this "generalized single as

80 included 391 families, containing up to 452 affected sib pairs, we found linkage evidence in four re

81 Tabulation of allele sharing in affected sib pairs with D20S197 and D12S349 suggests tha

82 An excess of sex-concordant affected sib pairs with HD has been noted but has been a

83 nt study, we model locus heterogeneity among affected sib pairs with prostate cancer by including cov

84 We performed exome sequencing on an affected sib-pair with normal ultrastructure in more tha

85 We have genotyped 77 affected sib-pairs with autoimmune thyroid disease for e

86 , multipoint linkage methods were applied to affected sib-pairs with inflammatory bowel disease, and

87 onditional on the trait data for a sample of affected sib pairs, with disease penetrances and disease

88 Two-point linkage analysis using affected sib pairs yielded LOD scores of 3.15 at D12S162