ライフサイエンスコーパス: affected with

1 hoprim for 24 h, the microbiota was strongly affected, with (1) up to 21-fold decrease in 16S rRNA ge

2 Tumor number was not affected with 1alpha,25-(OH)(2)-D(3) or vitamin D analog

3 sexual relationships were the most adversely affected with 33%, 26%, and 23% of the women responding

4 Language function was most affected, with 35% of 146 children below average.

5 ever, sub-Saharan Africa remains endemically affected with 5/7 serotypes currently known to be circul

6 HF patients were symptomatically mildly affected, with 8.8% of all LSs classified as New York He

7 Optical depth of focus was not affected with a 3-mm pupil, whereas with a 6-mm pupil, t

8 uded patients with <1 affected tooth, and >2 affected with a clinical AL >/= 6mm.

9 rane potential waveform of the LP neuron was affected with a consistent pattern.

10 Body weight was mildly affected with a delay in reaching mature weight.

11 t a 3-generation pedigree with 5 individuals affected with a dominantly inherited macrothrombocytopen

12 (2) located in nonfrigid zones has been salt-affected with a frequency of reoccurrence in at least th

13 Some of these nuclei are affected with a high number of neuritic plaques without

14 Two siblings affected with a mild form of JS were found to have a hom

15 luded a minimum of three available relatives affected with a psychotic illness and three available un

16 ac-Saint-Jean (SLSJ) region was particularly affected with a rate of 3.4 per 100000 person-years in 2

17 ls with de novo frameshift variants in NOVA2 affected with a severe neurodevelopmental disorder chara

18 n five children from four unrelated families affected with a similar pattern of severe intellectual d

19 a from thousands of samples from individuals affected with a wide range of diseases, but for whom the

20 s the rule-with relatives of insane patients affected with a wide variety of psychiatric, and sometim

21 In contrast, the GPi was less affected, with a 38% reduction in overall volume only.

22 ats, many times during the lifetime of those affected, with a bias towards expansion.

23 The rest of the dentition was less affected, with a diagnosis of generalized slight chronic

24 er compounds not present in the extract were affected, with a different behaviour observed depending

25 gene specific; hTERT was most significantly affected, with a higher frequency of MAE in adult and ad

26 Development is affected, with a loss of about 10 developmental quotient

27 Ion exchange was also affected, with a small but significant decrease in hemol

28 The oral cavity is frequently affected, with a wide variety of signs and symptoms that

29 erived thymus/parathyroid primordia was also affected, with absent or hypoplastic primordia, delayed

30 More than 45 million people are affected with acne vulgaris.

31 In this report, we studied a family affected with acrokeratosis verruciformis in six generat

32 ecursor protein (APP) and in the human brain affected with AD.

33 cted high incidence of this DFSP in children affected with adenosine deaminase-deficient severe combi

34 tures of enamel and cementum of feline teeth affected with advanced FORL.

35 togenesis in these mutants was progressively affected with age, resulting in decreased testis weight

36 continues to rise, the number of individuals affected with age-related cognitive decline and Alzheime

37 Humans retinas affected with age-related macular degeneration (AMD) wer

38 It was tested in twins affected with age-related macular degeneration (AMD).

39 is of genomewide linkage studies of families affected with age-related maculopathy (ARM), we previous

40 expected, the hematopoietic system was most affected, with all subjects developing cytopenias.

41 osis and homeostasis but, unlike individuals affected with ALPS, also have defects in their activatio

42 Individuals affected with ALS4 usually have an onset of symptoms at

43 DNA modification analysis of twins affected with Alzheimer's disease reveals a potential fo

44 Counseling individuals affected with AMD regarding the use of the AREDS2 supple

45 years' time, 196 million individuals will be affected with AMD.

46 was detected in German Shorthaired Pointers affected with an allelic disorder.

47 e, we identified seven unrelated individuals affected with an apparent dominant ZSD in whom a heteroz

48 type and genetic information for individuals affected with an ASD and family members is crucial for t

49 s extent (40 and 33%, respectively) the most affected with an important descend in leucine release.

50 n this study, we investigated eight patients affected with an overlapping genodermatosis after recess

51 In contrast, activation was markedly affected, with an EC(50) of 12.0 +/- 2.5 nM compared wit

52 r molecular layer of dentate) were initially affected, with anterograde progression though the hippoc

53 adolescents are more likely than males to be affected with anxiety disorders, but less likely to have

54 Specifically, macrophages were most affected, with approximately 2.5-fold fewer macrophages

55 ion of NF-kappaB responses, is most commonly affected, with approximately 30% of patients displaying

56 ll siblings and half siblings of individuals affected with ASD born between 1990 and 2003.

57 age 5 years, one third of all children were affected with at least one of the conditions of atopic d

58 with polyvascular disease (>=2 vascular beds affected with atherosclerosis), impaired renal function,

59 s performed on a family with identical twins affected with autism and severe, intractable seizures.

60 ex families, each with at least two siblings affected with autism or ASD phenotype.

61 ions in whole genomes from 1,902 individuals affected with autism spectrum disorder (ASD) and their u

62 nome scan of 24 family members, including 14 affected with autoimmune disease, showed significant lin

63 candidate approach in a Saudi Arabian family affected with autosomal recessive SCAN1, we identified a

64 ions in several families of Pakistani origin affected with autosomal recessive woolly and sparse hair

65 Here we report two additional individuals affected with BBIS originating from the north of Europe

66 ng of a DNA sample from a 17-year-old female affected with BBS did not identify any mutation in the k

67 OX2R(-/-) and orexin(-/-) mice are similarly affected with behaviorally abnormal attacks of non-REM s

68 omain of K(V)7.2 have been found in children affected with benign familial neonatal seizures (R213W m

69 of 200 individuals from 41 families multiply affected with bipolar disorder (BD) to identify contribu

70 Approximately 1 in every 50 to 100 people is affected with bipolar disorder (BD), making this disease

71 Few neuroimaging studies compare individuals affected with bipolar disorder (BP), at high familial ri

72 d with schizophrenia and all of the families affected with bipolar disorder were multiply affected wi

73 can of 41 Ashkenazi pedigrees with a proband affected with bipolar I disorder (BPI) and at least one

74 disorder (BPI) and at least one other member affected with BPI or bipolar II disorder (BPII), we iden

75 ubset of pedigrees limited to relative pairs affected with BPI.

76 ein is overexpressed in the breasts of women affected with cancer.

77 ncreased expression in the teeth of patients affected with caries and pulpitis.

78 In contrast, OX2R(-/-) mice are only mildly affected with cataplexy-like attacks of REM sleep, where

79 Individuals with a sibling affected with CD had a 2.03-fold (95% CI, 1.29-3.19) inc

80 ss NHL risk among individuals with a sibling affected with CD suggests shared susceptibility.

81 s in PMPCA in 17 patients from four families affected with cerebellar ataxia, including the large Leb

82 ugs--and atypical differences in individuals affected with certain clinical disorders (e.g., autism,

83 Finally, we showed in patients affected with cGVHD a higher B-cell division rate that c

84 some 6-linked NCMD (MCDR1) and 2 individuals affected with chromosome 5-linked NCMD (MCDR3).

85 ed on 8 affected individuals from 3 families affected with chromosome 6-linked NCMD (MCDR1) and 2 ind

86 Families with multiple individuals affected with chronic lymphocytic leukemia (CLL) and oth

87 obese (body mass index >30 kg/m(2)) patients affected with chronic periodontitis.

88 rg200Trp), was identified in all individuals affected with Chuvash polycythemia.

89 ic reticulum in fibroblasts from individuals affected with CLSD.

90 those with and without two or more relatives affected with compulsive hoarding.

91 rozygous mutation in the SOX2 gene in a male affected with congenital bilateral anophthalmia, hypogon

92 ering of specific gene mutations in children affected with congenital central hypoventilation syndrom

93 T2) gene have been identified in individuals affected with congenital generalized lipodystrophy (CGL)

94 We describe a white family with two siblings affected with congenital hypotonia early-onset glaucoma,

95 uited more than 25 families in which members affected with corpus callosum hypoplasia (CCH) lacked sy

96 tive neutrophil phenotype, patients severely affected with COVID-19 are characterized by excessive pl

97 ed on the proband and first-degree relatives affected with CRC to reduce ascertainment bias and overe

98 a clinical and genetic analysis of patients affected with CSNB due to TRPM1 mutations.

99 A family with 2 children affected with CTE was identified.

100 e mutant alleles, also described in patients affected with CTLN1, interact to produce a range of phen

101 In this report, we studied a family affected with Darier's disease and identified a deletion

102 across the exome sequences of 48 individuals affected with DCM from 17 families to identify genetic c

103 N truncating variants carried by individuals affected with DCM in 7 of 17 DCM families (logarithm of

104 n contrast, myeloid development is adversely affected with decreased in vitro colony formation, decre

105 B-cell maturation was also affected, with decreased IgD(+)CD27(+) memory B cells wh

106 ine homozygous SH2B3 mutations in 2 siblings affected with developmental delay and autoimmunity, one

107 tomography in 1,125 individuals in families affected with diabetes.

108 of 21 patients from the outbreak cohort were affected with diarrhea.

109 Twelve families that were multiply affected with diffuse idiopathic skeletal hyperostosis (

110 ich is severely disturbed in preterm infants affected with diffuse white matter injury, is incomplete

111 However, other brain regions are inevitably affected with disease progression.

112 s ManNAc as a potential treatment for humans affected with disorders of glomerular hyposialylation.

113 ions at residues Glu724 and Asp725 were most affected with double mutations at these sites showing ap

114 A set of individuals affected with DSM-IV OCD, a subset of their parents, and

115 om the Census Bureau, to estimate the number affected with each condition.

116 ccus mutans in plaque biofilms from children affected with early childhood caries.

117 ccus mutans in plaque-biofilms from children affected with early-childhood caries, a prevalent and co

118 enced the complete genomes of 72 individuals affected with early-onset familial Alzheimer's disease c

119 in two CAE-affected persons and two persons affected with EEG-recorded spike and/or sharp wave in a

120 We found that the surface expression is affected, with effects paralleling those seen with the b

121 nalysis of a large cohort of cases (n = 269) affected with either classic heterotaxy or looping CVM r

122 ferentiated between unaffected dogs and dogs affected with either mutation with a high degree of cert

123 poA-I 133+/-21 mg/dL) (P<0.0005) or subjects affected with either R1851Q (n=6) (HDL-C 36+/-8; ApoA-I

124 ed in several families with multiple members affected with endometrial carcinoma.

125 Four PWD full-siblings affected with EOPRA diagnosed at 2-3 years of age were g

126 Our report highlights the fact that subjects affected with eye anomalies and harboring SOX2 mutations

127 e PPT primer, all mutants were significantly affected with F61Y and F61A being most severely impaired

128 All males and female carriers affected with Fabry disease should be followed closely,

129 ontrolled study of 41 subjects genotypically affected with familial adenomatous polyposis but phenoty

130 range, 8 to 25 years) who were genotypically affected with familial adenomatous polyposis but phenoty

131 aps the locus identified in several kindreds affected with familial chondrocalcinosis.

132 ALB2 (also known as FANCN) in seven families affected with Fanconi anemia and cancer in early childho

133 asymptomatic at initial screening, were also affected with FDC at follow-up.

134 encing on two families with multiple members affected with focal epilepsy and linkage analysis on one

135 patients with familial thrombocytopenia are affected with forms of unknown origin.

136 , complementary results from mice and humans affected with GD1 not only pinpoint sphingosine as being

137 Kidneys are initially affected with generalized proximal tubular dysfunction (

138 Interestingly, cerebellum was the area most affected, with greater myelination impairment and glia b

139 f 96 small families with one or two children affected with GTS was also studied.

140 s now apparent that the majority of patients affected with HCM can achieve normal or near-normal life

141 Thirty-one consecutive children affected with Henoch-Schonlein syndrome who were from 3.

142 cancer cells and linkage studies in families affected with hereditary prostate cancer (HPC) have impl

143 In patients affected with HGPPS, we identified mutations in the ROBO

144 ound heterozygous mutations in four siblings affected with HHS, in the gene encoding the regulator of

145 Among families affected with HPC, we identified six rare missense mutat

146 ormations, but males are usually more mildly affected with hypertelorism as the only feature.

147 ologue, EDARADD, that is present in a family affected with hypohidrotic ectodermal dysplasia.

148 A 49 years old woman affected with i-CRLM from adenocarcinoma of right colon,

149 olated with increasing frequency from cattle affected with IBK.

150 s pedigree of Arab origin with seven members affected with ID and mild dysmorphic features.

151 from the perspective of cancers in patients affected with IEM and discuss how dysregulation of these

152 gas species on atmospheric particles may be affected, with important implications for climate predic

153 in kinase (MAPK) pathways were predominantly affected, with increased levels of phospho-p38 and phosp

154 amount of medium-range order seems slightly affected with increasing Ag concentration (0, 2, 5 at.%)

155 positive impact on individuals and families affected with inherited eye disease in a number of ways.

156 seropositivity rates compared between horses affected with insect bite hypersensitivity (IBH) and con

157 (ISGs) are overexpressed in human T1D islets affected with insulitis.

158 two-stage genomewide screen of 48 sib pairs affected with intracranial aneurysms (IAs) that revealed

159 ease in a large family with multiple members affected with IS.

160 regarding the molecular genetics of children affected with juvenile dermatomyositis and the impact th

161 VC dechlorination was most affected, with k(max)X values decreasing by a factor of

162 d 17-HDHA were then tested in 62 individuals affected with knee osteoarthritis and 52 age matched con

163 logical features observed in rhesus macaques affected with Krabbe's disease.

164 fibres (<3 microm2) seem to be particularly affected, with large fibres remaining relatively preserv

165 y dispersed collection of families, multiply affected with late onset Alzheimer's disease, who were p

166 Having a parent affected with late-onset Alzheimer's disease (AD) is a r

167 Having a parent affected with late-onset Alzheimer's disease (LOAD) is a

168 e mutation was found in three family members affected with late-onset atypical hemolytic uremic syndr

169 expressivity; while some patients are mildly affected with learning disabilities and subtle craniofac

170 ude du Polymorphisme Humaine and 28 families affected with learning disabilities.

171 by direct sequencing of DNA from 36 patients affected with Leber's congenital amaurosis (LCA), 62 wit

172 ring familial evaluation; 38 were clinically affected with left ventricular hypertrophy >/=13 mm.

173 s identified in a family with three children affected with lethal fetal akinesia sequence.

174 s study found that 10% of individuals become affected with LHON after 50 years of age.

175 inal study of families with multiple members affected with LOAD.

176 .0), given at least 2 first-degree relatives affected with lone AF.

177 Unfortunately, children affected with LS often die early of health complications

178 Previously, we hypothesized that cells affected with LSD have increased energy expenditure for

179 g and management of patients at risk for and affected with Lynch syndrome as follows: Figure 1 provid

180 ogical offspring with 2 previous generations affected with major depression were at highest risk for

181 mpact on the clinical management of families affected with MCPH.

182 pedigree software, that 23 nuclear families affected with MCPHA are connected to a single ancestral

183 ly increased in the brains of human subjects affected with MDD and rats exposed to chronic social def

184 Overall, teeth/sites most affected with mean CAL>=2.1 mm were noted in 2,3(ML), 3(

185 f the overall sample showed teeth/sites most affected with mean PD > 2.1 mm were molars (2,3,15,18,19

186 re also present in vessels from human livers affected with metastases.

187 feasible alternative treatment for patients affected with mild/moderate CAEBV infection and that thi

188 d, whereas the 129P3/J mouse strain is least affected, with minimal dental fluorosis.

189 the ARSA gene of fifteen unrelated patients affected with MLD.

190 The selenoprotein population was selectively affected with MMTV-Cre in breast and skin but not in the

191 genetic abnormalities in a 25-year-old woman affected with MNGIE.

192 y intervention in offspring of 2 generations affected with moderate to severely impairing MDD seems w

193 ty-two patients with two contralateral teeth affected with moderate-to-severe CP were selected.

194 erventions in the offspring of 2 generations affected with moderately to severely impairing MDD seem

195 ied a large kindred with several individuals affected with molar oligodontia that was transmitted as

196 e onset of the clinical phenotype; mice were affected with more severe thrombotic lesions.

197 f cases, multiple chromosomes per tumor were affected, with most chromothriptic events on chromosomes

198 ctivating protein that is absent in a family affected with MRX, is required for dendritic spine morph

199 lear families, comprised of four individuals affected with MS and their HLA-identical siblings.

200 We have studied family N, which is affected with multiple colorectal adenomas and carcinoma

201 extent of surgical intervention in children affected with multiple endocrine neoplasia type 2 will l

202 dings, however, have indicated that patients affected with myofibrillar myopathy have a more distal t

203 drially encoded proteins were differentially affected, with near normal levels of cytochrome c oxidas

204 Data from 28 consecutive patients affected with neovascular AMD that presented subretinal

205 lies with two or more first-degree relatives affected with neuroblastoma to localize a hereditary neu

206 ly developing individuals and in individuals affected with neurodevelopmental disabilities.

207 Clinically, the neurons in layer II are affected with neurofibrillary tangles, one of the two pa

208 howed that only the extent of inhibition was affected, with no change in agonist potency (EC(50) = 1

209 Labrador retrievers and Samoyeds affected with non-allelic forms of OSD exhibit vitreous

210 tations were detected in 4.4% of individuals affected with non-HPC as compared with 0.8% of unaffecte

211 ased sex ratio, whereas families of probands affected with non-sexually dimorphic autoimmune diseases

212 Exome sequencing in an individual affected with non-syndromic RP revealed two plausibly di

213 ons, p.Gly60Asp and p.Leu208Pro, in patients affected with nonsyndromic autosomal recessive intellect

214 nonsense mutations in BCOR in seven families affected with OFCD.

215 ons can be found in the majority of families affected with one of the inherited syndromes, and, most

216 ilies studied, 1,507 had at least one member affected with one of three known forms of CAH, namely sa

217 (D1, D2, and D3 lymphadenectomy) in patients affected with operable gastric carcinoma?

218 skeletal fragility phenotype in individuals affected with osteoporosis-pseudoglioma is inadequate pr

219 We ascertained three different families affected with oto-dental syndrome, a rare but severe aut

220 5(+)FOXP3(+) T(reg) cells in 104 individuals affected with ovarian carcinoma, that human tumor T(reg)

221 s in which three or more family members were affected with pancreatic cancer, at least two of which w

222 ried out genetic analyses in 201 individuals affected with Parkinson disease and 221 age-matched unaf

223 n, intrinsic optical signals persist in cats affected with PCG.

224 Among never-smokers, fewer teeth/sites were affected with PD > 2.1 mm, whereas among smokers, number

225 Sequence analysis of 2p13 linked individuals affected with PD did not reveal any potentially pathogen

226 L in T-cell functional responses in patients affected with pDGS.

227 mous missense variant) in a pair of siblings affected with persistent lymphoedema caused by congenita

228 olyps identical to those seen in individuals affected with PJS.

229 are needed with multiple-ethnic populations affected with POAG to strengthen these findings.

230 All tooth types were affected, with posterior teeth being affected earlier an

231 Percentage of individuals affected with PPCD and controls with an average keratome

232 th VWS and distinct mutations in 13 families affected with PPS.

233 rtalized renal epithelial cells of a patient affected with progressive medullary cystic kidney diseas

234 ly has at least three first-degree relatives affected with prostate cancer.

235 analyzed genome scan data from 161 pedigrees affected with prostate cancer.

236 s of 80 candidate genes in 201 brother pairs affected with prostatic adenocarcinoma.

237 n of CD57 on T cells in the skin of patients affected with psoriasis, comparing lesional and unaffect

238 Studies in families affected with pulmonary fibrosis, smokers with chronic o

239 All age groups are affected with rapidly growing importance in elderly peop

240 to a consanguineous family with one subject affected with RCD and identified a homozygous nonsense m

241 all male with an estimated body surface area affected with RDEB of 4% to 30%.

242 Elongation is particularly affected, with RECQL5 depletion causing a striking incre

243 Sarcolemma was less affected, with reductions of approximately 40% in PIP3 p

244 ontumbling chemotaxis mutant was only weakly affected with regard to biofilm formation under nonflowi

245 We studied families with multiple members affected with renal cancer to delineate clinically disti

246 loss or of restoring the vision of patients affected with retinal degeneration through some type of

247 e has been shown to be up to 25% in subjects affected with rhinitis with persistence, comorbidity and

248 x pedigrees, consisting of 453 subjects (134 affected with RLS).

249 he largest cohort, to date, of simplex males affected with RP or COD/CORD.

250 isorders among the offspring of parent pairs affected with schizophrenia (SCZ) and/or bipolar disorde

251 mortem expression analysis of 33 individuals affected with schizophrenia and 30 unaffected control su

252 Most of the families affected with schizophrenia and all of the families affe

253 implicated in psychotic illness in families affected with schizophrenia or psychotic bipolar disorde

254 family sample of 13 large families multiply affected with schizophrenia, 2 schizophrenia case-contro

255 ish individuals, including 4,877 individuals affected with schizophrenia, in ways informed by exome s

256 d functional studies in a cohort of patients affected with severe AD.

257 Plasma was infused into young horses (foals) affected with severe combined immunodeficiency (SCID), f

258 d that APOE-4 carriers are more likely to be affected with severe disease (P=.03), whereas a higher p

259 participants without skin lesions, patients affected with skin cancers had a significantly increased

260 ce quotient (approximately 50%) are commonly affected with specific neuropsychological problems, incl

261 However, some patients affected with squamous cell carcinoma (SCC) do not respo

262 hat female reproductive function may also be affected, with subsequent implications for fertility.

263 (OPRM1), among 382 European Americans (EAs) affected with substance dependence [alcohol dependence (

264 PBP4 DD-endopeptidase activity was also affected, with substitution of Asp155, Arg361, and Gln42

265 rofile and degree of inflammation of persons affected with such condition is an important step toward

266 ation assessing the insurability of families affected with Sudden Arrhythmia Death Syndromes (SADS) f

267 Genetic analyses of families affected with TAA have identified several chromosomal lo

268 that it is likely that multiple pathways are affected with the administration of this drug that needs

269 ltered by TPE-OLD in myoblasts from patients affected with the age-associated genetic disease, facios

270 living members of the House of Hanover were affected with the condition.

271 assified controls (i.e., individuals who are affected with the disease under study but who are classi

272 in individuals who have family members also affected with the disease.

273 affected with bipolar disorder were multiply affected with the illness.

274 Children affected with the inherited tumor predisposition syndrom

275 Individuals affected with the neurofibromatosis 1 (NF1) tumor predis

276 Twelve J-couplings are affected, with the largest being (1)J(C5,C6) ( approxima

277 Increased IL-6 levels are found in tissues affected with these diseases, and KSHV exists in a laten

278 g the morbidity and mortality of individuals affected with these disorders.

279 HPDL variants in each of the 17 individuals affected with this clinically heterogeneous autosomal-re

280 cacy of current treatments for those already affected with this disease has prompted the suggestion t

281 ncidence of skin cancer observed in patients affected with this disorder.

282 ders the opportunity to avoid producing dogs affected with this form of PRA.

283 observed in EC superficial layer and further affected with time.

284 ltures of human fetal cells from pregnancies affected with trisomy 21 (t21) and trisomy 13 (t13).

285 fundus autofluorescence (FAF) images of eyes affected with tubercular SLC from the acute stage until

286 Persons affected with tuberous sclerosis complex (TSC) develop a

287 tinguishing between unaffected dogs and dogs affected with two different forms of inherited retinal d

288 unrelated patients (2 males and 13 females) affected with typical IH, 12 patients (9 males and 3 fem

289 We have identified 25 pedigrees that are affected with typical JOAG and that demonstrate autosoma

290 In FRDA, the heart is frequently affected with typical manifestation of hypertrophic card

291 Human populations will also be affected, with up to ~2,100 million of the poorest peopl

292 ic amplification (PMCA) in urine of patients affected with variant Creutzfeldt-Jakob disease (vCJD),

293 1.71-2.75; P<.001]) and number of body parts affected with vitiligo (P</=.009) but not laterality (P=

294 Patients affected with von Hippel-Lindau disease are at risk of d

295 in IRF6 in 45 additional unrelated families affected with VWS and distinct mutations in 13 families

296 bors the causative mutation, all individuals affected with WARBM exhibit indistinguishable clinical p

297 In a large family affected with Wilms tumor, 84% of variants uniquely iden

298 e describe somatic mosaicism in two brothers affected with Wiskott-Aldrich syndrome (WAS).

299 ently reported in a small number of patients affected with Wiskott-Aldrich syndrome (WAS).

300 cance in the patient or direct relative also affected with X-linked hypophosphataemia.