ライフサイエンスコーパス: afferent

1 cell, and a maintained inward current in the afferent.

2 sensitive conductances in both hair cell and afferent.

3 formation about its long-range efferents and afferents.

4 gonadal hormones to sex differences in vHPC afferents.

5 f optogenetic stimulation of thalamocortical afferents.

6 and subcortical regions with known striatal afferents.

7 alance of entorhinal versus intrahippocampal afferents.

8 ase induced by activation of thalamostriatal afferents.

9 ion properties of identified primary tactile afferents.

10 ctions into zones, as they do for excitatory afferents.

11 iverse cell types, extracellular matrix, and afferents.

12 uning properties in remaining binocular dLGN afferents.

13 from the weight profiles of its presynaptic afferents.

14 l areas and is directly recipient of retinal afferents.

15 ked neuronal detection thresholds across all afferents.

16 s of visceral pain) are the domain of nodose afferents.

17 helial cells communicate directly with colon afferents.

18 and running scales both SST and PV synaptic afferents.

19 antly altered cortical modulation of primary afferents.

20 tion velocities of some vagal signals in the afferent (0.7-4.4 m/s) and efferent (0.7-8.8 m/s) direct

21 homeostatic regulation and pain are found in afferents across all ganglia types, suggesting that cons

22 ChINs is attenuated by dopaminergic midbrain afferents acting presynaptically on D2 receptors.

23 d PAS require activity in (higher threshold) afferents activated by the muscle twitch evoked by elect

24 Notably, afferent activation increases with intrinsic neuronal va

25 rive on the shape of the temporal profile of afferent activity during movement.

26 s study was to quantify how much the primary afferent activity of muscle spindles can contribute to s

27 Next, we approximated the Ia afferent activity using a phenomenological model of the

28 holinergic, the activation of which inhibits afferent activity.

29 is the principal target of the serotonergic afferents along with the limbic system, and it was shown

30 Vestibular afferents also responded to electrical stimuli up to 300

31 d with respect to studies of the mouse vagal afferents, an area of research of increasing popularity.

32 otide-gated channel (HCN) conductance in the afferent and creates resistive coupling at the synaptic

33 l cells, vascular smooth muscle cells of the afferent and efferent arterioles, parietal epithelial ce

34 previously undescribed no-cross zone between afferent and efferent branches on the vascular pole side

35 bdivisions in the adult thalamus, whose main afferent and efferent connections were assessed by traci

36 es, we established physiological markers for afferent and efferent fiber activation by VNS: stimulus-

37 per rewiring of regenerated neurons to their afferent and efferent partners, and regaining of lost sp

38 overall estimate of glomerular pressure and afferent and efferent resistance in humans.

39 ion of renal nerves results in reduced renal afferent and efferent sympathetic nerve activity in the

40 OHCs also exhibited the progressive loss of afferent and efferent synapses.

41 midbrain dopamine neurons are controlled by afferent and intrinsic activity to generate sensory cue

42 Additionally, left VNS elicited a greater afferent and right VNS a greater efferent response.

43 re is complementary sprouting of the primary afferent and S1 CST populations into an overlapping regi

44 emain extracellular during transit, first in afferent and then efferent lymphatics that carry the bac

45 electrical vestibular stimuli on vestibular afferents and a current model of central vestibular proc

46 relationship between striatal glutamatergic afferents and behavioral reinforcement is not well under

47 3/MrgD-expressing nociceptive/pruritoceptive afferents and C-low threshold mechanoreceptors.

48 re sensation and pain are mediated by spinal afferents and fear and anxiety (the affective aspects of

49 rogen receptor-expressing neurons in primary afferents and in superficial dorsal horn neurons, there

50 s extremities, it contained a mixed of vagal afferents and postganglionic sympathetic neurons.

51 ses were observed close to primary olfactory afferents and projection neurons.

52 We found that both the spared primary afferents and somatosensory corticospinal efferents spro

53 source of highly opioid-sensitive GABAergic afferents and support the idea that different GABAergic

54 The cerebral cortex is the main striatal afferent, and progressive cortico-striatal disconnection

55 these ensembles are driven by primary bulbar afferents, and shaped by intracortical recurrent connect

56 such alignment was observed only for Merkel afferents; angular tuning of the other afferent types sh

57 We have shown that functional muscle spindle afferents are absent in the upper and lower limbs in HSA

58 Given that functional muscle spindle afferents are also absent in the upper limb, we assessed

59 CeA afferents are GABAergic (express Slc32a1/Vgat) and are d

60 PVH afferents are glutamatergic (express Slc17a6/Vglut2) and

61 In the face, cutaneous and muscle afferents are segregated in the trigeminal and facial ne

62 Delta(9)-THC through modulation of glutamate afferents arising from corticolimbic brain areas implica

63 viduals with HSAN III rely more on cutaneous afferents around the elbow.

64 ited impairments in the myogenic response of afferent arterioles and in renal blood flow autoregulati

65 ed similar distributions of villus and crypt afferents as control mice, suggesting surgery did not co

66 tin receptors (LepRs) are expressed by vagal afferents as well as by a population of NTS neurons.

67 vity of alpha motoneurons is required for Ia afferent-based co-contraction.

68 nomia, do not have functional muscle spindle afferents but do have essentially normal cutaneous mecha

69 of similarity in prefrontal and hippocampal afferents but some differences in afferent connectivity

70 quency signals encoded by primary vestibular afferents, but undergo low-pass filtering at intermediat

71 lls influence discharge rates in their calyx afferents by modulating the potassium concentration in t

72 l of head rotation encoded by the vestibular afferents can cause perceptions of both linear and angul

73 data demonstrate that transiently expressed afferent CB1Rs regulate afferent synaptic strength durin

74 Activation of these afferent CB1Rs suppresses synaptic transmission onto dev

75 Loss of auditory-nerve (AN) afferent cochlear innervation is a prevalent human condi

76 in a 165% (95% CI, 79% to 294%) increase in afferent compliance and a 13.1-mm Hg (95% CI, 10.0 to 16

77 Potassium sensitivity of hair cell and afferent conductances allows three modes of transmission

78 How the organization of cholinergic afferents confers this level of precision remains unknow

79 However, afferent connections often bypass feedforward circuitry,

80 naptic rabies virus tracings to characterize afferent connections onto either excitatory or inhibitor

81 an brain circuit analysis we have mapped the afferent connectivity of the mouse RE using retrograde F

82 ippocampal afferents but some differences in afferent connectivity with other brain regions.

83 ever, it is unknown how and when distinct PL afferents contribute to different associative components

84 Specific, peripheral C-tactile afferents contribute to the perception of tactile pleasu

85 by their amplitudes, permitting analysis of afferent convergence in vivo.

86 Compared with villus afferents, crypt innervation exhibited a muted proximal-

87 There were clusters of colon and bladder afferents, defined by mRNA profiling, that localized to

88 This was also the case following afferent denervation.

89 a temporal pattern consistent with increased afferent-dependent activity.

90 Therefore, estimates of vagal villus afferent distributions (control minus VAGX) paralleled c

91 vidence that, in humans, both descending and afferent drives project onto the same spinal interneuron

92 metry to record in vivo activity in vHIP-NAc afferents during tests of depressive- and anxiety-like b

93 rmined projection-specific activation of OFC afferents during the relapse test by using Fos plus the

94 Analyzing the afferent electrosensory input shows that a significant g

95 Here, we demonstrate that vestibular primary afferents encode high-frequency stimuli through frequenc

96 red to other visceral organs, uterine spinal afferent endings displayed noticeably less morphological

97 de (CGRP)-immunoreactivity of uterine spinal afferent endings supplied by thoracolumbar DRG.

98 nd morphological characterization of primary afferent endings to describe the physical and cellular p

99 Most spinal afferent endings were CGRP-immunoreactive and morphologi

100 mine signals both in vivo and in vitro These afferents engage cholinergic interneurons, which drive d

101 facial muscles are predominantly peptidergic afferents enriched with TRPV1.

102 nificantly decreased the strength of primary afferent-evoked glutamatergic drive onto DYN neurons wit

103 mouse SDH while increasing the appearance of afferent-evoked inhibition onto the same population.

104 rn (SDH) that include a reduction in primary afferent-evoked, feedforward inhibition onto adult proje

105 most responsive region to cocaine among LHb afferents examined and that single cocaine infusions ind

106 nexplored role of sensory SGCs in decreasing afferent excitability.

107 All afferents exhibited strong "angular tuning," i.e., their

108 Furthermore, colon and bladder afferents expressed genes at similar levels, although di

109 t in insulin-resistant animals, portal vagal afferents failed to inhibit their spiking activity durin

110 trathecal fentanyl to attenuate group III/IV afferent feedback from lower limbs to modify the EPR, wh

111 s suggest that locomotor muscle group III/IV afferent feedback in HFrEF leads to increased systemic v

112 indicate that locomotor muscle group III/IV afferent feedback in patients with HFrEF leads to increa

113 tor drive that transform the monosynaptic Ia afferent feedback into task-dependent co-contraction of

114 F is excessive locomotor muscle group III/IV afferent feedback; however, this has never been investig

115 received monosynaptic innervation from vagal afferent fibers and LepR neurons exhibited large synapti

116 sion electron microscopy showing that single afferent fibers follow a single dendrite mostly up to th

117 First, we briefly discuss the receptors, afferent fibers, and pathways involved in conveying tact

118 e is a pure motor nerve, we presume that the afferent fibres responsible were those activated by the

119 of sustained synaptic transmission onto the afferent fibres.

120 sformed into the diversity of muscle spindle afferent firing patterns observed experimentally, partic

121 ound at all anatomic levels, suggesting that afferents from different portions of the neuraxis have o

122 omprising many glomerular modules defined by afferents from different receptor neuron subtypes.

123 fferentially in layers II/III and V striatal afferents from motor cortex and that cortical BDNF is es

124 kely mediated by stimulation of MORs in GABA afferents from other brain regions than in VTA GABA neur

125 Moreover, the maturation of mossy fiber afferents from pontine neurons and the expression of the

126 sly to suppress representation of excitatory afferents from PPG neurons, thereby diminishing the impa

127 nal cord horn that receives visceral sensory afferents from the bladder and distal colon, a pathologi

128 e solitary tract (NTS) is activated by vagal afferents from the gastrointestinal tract, which promote

129 In rodents, nucleus accumbens (NAc) afferents from the ventral hippocampus (vHIP) are implic

130 synergistic model, we highlight dopaminergic afferents from the ventral tegmental area to nucleus acc

131 mouse behavioral models, that glutamatergic afferents from the ventral tegmental area to the dorsal

132 sed to identify functional clusters of colon afferents from thoracolumbar (TL), lumbosacral (LS), and

133 A total of 132 colon afferents (from NG, TL, and LS ganglia) and 128 bladder

134 from NG, TL, and LS ganglia) and 128 bladder afferents (from TL and LS ganglia) were analyzed.

135 triggered by transmitters released by vagal afferents, glutamate acting at AMPA receptors and 5-HT a

136 Afferent grip-intensity levels are also decoded from M1,

137 Nociceptive afferents in craniofacial muscles are predominantly pept

138 e used optogenetics to stimulate cholinergic afferents in prefrontal cortex brain slices from compoun

139 ng in vivo two-photon Ca(2+) imaging of dLGN afferents in superficial layers of V1 in female and male

140 Stimulation of low threshold afferents in the trigeminal nerve produced a clear SAI (

141 Representing highly relevant afferents in three-dimensional body-part-models might fa

142 Low-frequency stimulation of PAG afferents in vitro unexpectedly causes long-term potenti

143 aracteristics of mammalian muscle spindle Ia afferents - including movement history dependence, and n

144 d neuroplastic changes in trigeminal sensory afferents, increasing calcitonin gene-related peptide ex

145 Stimulation of trigeminal afferents induced short-latency (SAI) but not long-laten

146 nts of the brainstem mechanisms that process afferent information and modulate baroreflex sensitivity

147 by various central nervous regions based on afferent information from baroreceptors, chemoreceptors,

148 -inhibitory balance, and alter processing of afferent information from the ventral hippocampus.

149 using short-afferent inhibition (SAI), long-afferent inhibition (LAI) and LTP-like plasticity follow

150 tions in face motor cortex (fM1) using short-afferent inhibition (SAI), long-afferent inhibition (LAI

151 ort-latency (SAI) but not long-latency (LAI) afferent inhibition of face M1, while facial nerve stimu

152 e influence of locomotor muscle group III/IV afferent inhibition via lumbar intrathecal fentanyl on p

153 sensorimotor interaction, i.e. short-latency afferent inhibition, were recorded from 15 healthy subje

154 abeling from the colon showed that NG and TL afferents innervate proximal and distal regions of the c

155 Within trigeminal ganglia, afferents innervating craniofacial muscles interact with

156 Vagal afferents innervating the small intestinal mucosa regula

157 we combined anatomic quantifications of the afferent innervation in gerbils of both sexes with compu

158 so sought to determine the degree of uterine afferent innervation provided by the vagus nerve.

159 circadian clock have the ability of encoding afferent input from osmosensors and generating appropria

160 Afferent input from pulmonary arterial baroreceptors may

161 This region receives primary afferent input from the periphery, and cortical input vi

162 elative contribution of cutaneous and muscle afferent input to each effect.

163 ns and the location of the neurons providing afferent input to them.

164 py and modality, and have a diverse range of afferent inputs and projection targets.

165 dings reveal tuning of individual vestibular afferent inputs and their postsynaptic targets.

166 ganizing dorsal horn; (2) S1 CST and primary afferent inputs connect in different ways within this re

167 Furthermore, these neurons received afferent inputs from a range of upstream brain regions a

168 s investigating the effects of somatosensory afferent inputs on cortical excitability and neural plas

169 fferences in effects of cutaneous and muscle afferent inputs on face M1 excitability suggest they pla

170 for the inhibitory influence of nociceptive afferent inputs on low-threshold motor units.

171 n onto recipient muscles with muscle spindle afferent inputs only.

172 ortex, whose activity is driven primarily by afferent inputs rather than by intrinsic dynamics.

173 heart and blood vessels, respond to incoming afferent inputs with [Ca(2+)](i) elevations.

174 ns even after minimizing pulmonary and chemo-afferent inputs.

175 or beliefs and/or the precision-weighting of afferent interoceptive signals may facilitate the transd

176 origin of the cell bodies of uterine spinal afferents is clear, the identity of their sensory ending

177 rly considering new evidence that overlap of afferents is substantial.

178 During high-frequency stimulation of vagal afferents, leptin increased the size of NMDAR-mediated c

179 tivated CD4 T cells enter downstream LNs via afferent lymphatics at high frequencies.

180 g lymph node (LN)-homing of immune cells via afferent lymphatics.

181 ) ) contributes to setting the hair cell and afferent membrane potentials; the potassium efflux from

182 will be valuable for studying vagal mucosal afferent morphology, interactions with other GI elements

183 derstanding of how neuronal phase locking of afferent MSO structures, and MSO membrane biophysics sub

184 diators such as ATP, which in turn modulates afferent nerve activity in response to bladder filling d

185 rimentally demonstrate an artificial spiking afferent nerve based on highly reliable NbO(x) Mott memr

186 Spinal afferent nerve endings did not express TH, and lacked th

187 ide the first detailed description of spinal afferent nerve endings in the uterus of a vertebrate.

188 sitive ion channel, was present at the vagus afferent nerve endings innervating the aortic arch to fu

189 Distinct morphological types of spinal afferent nerve endings were identified throughout multip

190 tion of predominantly nociceptive peripheral afferent nerve fibers in head-restrained transgenic mice

191 able muscle tissue, and to stimulate severed afferent nerve fibers to provide somatosensory feedback.

192 al ion channel TRPA1 is expressed by primary afferent nerve fibres, in which it functions as a low-th

193 al ganglion (SG), stria vascularis (SV), and afferent nerve fibres.

194 However, an interface (called an afferent nerve in biology) with the environment, which c

195 The experimental results indicate that our afferent nerve is promising for constructing self-aware

196 The spiking frequency of the afferent nerve is proportional to the stimuli intensity

197 Using this afferent nerve, we further build a power-free spiking me

198 onse induced by stimulation of P2X in muscle afferent nerves of PAD rats.

199 ervation to the uterus is provided by spinal afferent nerves, whose cell bodies lie predominantly in

200 the secretory state of beta-cells via vagal afferent nerves.

201 orce to the inner hair cells that synapse on afferent nerves.

202 Vagal afferent neuron (VAN) signaling sends information from t

203 Connections from intrinsic primary afferent neurons (IPANs), to ascending motor and interne

204 d the increase in P2X currents in the muscle afferent neurons of PAD rats.

205 dual retrograde tracing revealing that many afferent neurons project axon collaterals to both the la

206 dorsal root ganglia (DRG) house the primary afferent neurons responsible for somatosensation, includ

207 Single cell RT-PCR on lung-specific vagal afferent neurons revealed that both TRPV1-expressing and

208 underlies the gut-brain axis, is via spinal afferent neurons, with cell bodies in dorsal root gangli

209 o electrical signals that are relayed to the afferent neurons.

210 n subepithelium, detrusor smooth muscles and afferent neurons.

211 kers of postganglionic sympathetic and vagal afferents neurons.

212 In myelinated afferents, nodal length increased postoperatively [pre:

213 cord and central targets of primary sensory afferents (nucleus of the solitary tract, spinal trigemi

214 push-pull" encoding of stimulus direction by afferents of opposite polarity is disrupted while still

215 ther the elimination of unmyelinated primary afferents of the adjacent uninjured nerves (L3 and L4) w

216 es that have systematically investigated the afferents of the RE have only been performed in rats.

217 stal regions of the colon, whereas 98% of LS afferents only project to distal regions.

218 Selective activation of afferent or efferent vagal fibers can maximize efficacy

219 ether hyperalgesic priming in nonpeptidergic afferents or repeated acid injections also affect cranio

220 Chemogenetic silencing of TRPV1-expressing afferents or rostral ventromedial medulla neurons attenu

221 Stimulating either mCbN afferents or TH neurons augments IPSCs and suppresses EP

222 lamina I of the spinal cord, which transmits afferent pain, temperature, and itch information up to t

223 s evoked MGF responses, we conclude that the afferent pathway for MGF-mediated escape is glutamatergi

224 o the principal NAcSh projection neurons and afferent pathways in mice during free feeding assays.

225 Among the principal excitatory afferent pathways, we showed that ventral hippocampal (v

226 Cathode cephalad polarity caused an afferent pattern of responses (relatively stronger Delta

227 he gAP also provides a means for integrating afferent patterns of activity but on a slower timescale

228 ally isolated from extrasubicular excitatory afferents, pharmacologically disinhibited subicular slic

229 rotractor nucleus that also has a motoneuron afferent population.

230 n atlas to map, ablate, and control specific afferent populations.

231 on, the absence of which results in immature afferent processing and a hypofunctional state.

232 In contrast, the simulated Ia afferent profiles were not changing between tasks and th

233 Craniofacial muscle afferents project to a wide area within the trigeminal n

234 are active during motor behavior to suppress afferents projecting to the brain [7-12].

235 an brainstem, and we define the efferent and afferent projection patterns of LJA5 neurons in mouse.

236 le of the orbitofrontal cortex (OFC) and its afferent projections in relapse to fentanyl seeking.

237 ly modulated, and systematic analysis of its afferent projections is required to understand its conne

238 cognate prolactin receptor (PRLR) in primary afferents promotes nociceptor sensitization and pain in

239 Fifty participants with relative afferent pupillary defects (RAPDs) confirmed using the s

240 periphery reshapes these circuits as soon as afferents reach the cortex.

241 ted of characteristic impedance, compliance, afferent resistance, and Pglom.

242 Single unit muscle spindle afferent responses from isolated mouse extensor digitoru

243 collic reflexes, we then recorded vestibular afferent responses to the same electrical stimuli in mon

244 However, the mechanisms governing afferent responsiveness to dually modulate these process

245 nsitivity increased with frequency up to the afferent resting firing rate (~100-150 Hz) and at higher

246 inflamed neurons as well as nearby uninjured afferents, resulting in hyperalgesia and ectopic pain or

247 nd electrical stimulation of corticostriatal afferents revealed that histamine, acting at H(3) recept

248 Double labeling of JO and ocellar afferents revealed that input from the JO and visual inf

249 Anterograde double staining of the antennal afferents revealed that JO receptor neurons project to s

250 vagal neurons that are positioned to have an afferent role in microbiota-mediated modulation of gut s

251 This correlated with primary muscle afferent sensitization and increased expression of glial

252 se-mediated reflexes and group III/IV muscle afferent sensitization.

253 poxia, hypercapnia, and acidemia to activate afferent sensory fibers terminating in the respiratory a

254 activate the same neural representations as afferent sensory input.

255 rd, which are heavily populated with primary afferent sensory neurons.

256 We discover afferent sensory pathways and a large population of neur

257 racing technique to selectively label spinal afferent (sensory) nerve endings that innervate the peri

258 These data support the proposition that afferent signalling from skin wetness enhances the desir

259 r discharge at ventricular systole underpins afferent signalling of cardiovascular arousal.

260 other type of nonlinear transformation of Ia afferent signals that is independent of signals modulati

261 Application of a CB1R antagonist during afferent stimulation trains and depolarizing voltage ste

262 ts of cisplatin, less is known regarding the afferent synapse, which is an essential component in the

263 arge appositions such as the hair cell-calyx afferent synapses present in central regions of the turt

264 The loss of afferent synapses was present in all strains at 15 month

265 Afferent synapses were lost from inner hair cells throug

266 us or exogenous activation of CB1Rs modifies afferent synaptic strength and coordinated downstream ne

267 ransiently expressed afferent CB1Rs regulate afferent synaptic strength during synaptogenesis, which

268 TBM revealed marked hypoplasia of cerebellar afferent systems in DS, including fronto-pontine (middle

269 aggregation into barrels and thalamocortical afferent (TCA) segregation.

270 rate (~100-150 Hz) and at higher frequencies afferents tended to phase-lock to the vestibular stimulu

271 size profile of the spared/sprouted primary afferent terminal boutons post-lesion.

272 Most crypt and villus afferent terminals along the entire proximal-distal smal

273 cannabinoid receptor, CB1R, is expressed on afferent terminals instead of output neuron Purkinje cel

274 synapses colocalized with the post-synaptic afferent terminals is likely to increase, indicating the

275 est that glutamate and 5-HT, released by NTS afferent terminals, trigger Ca(2+)-dependent astroglial

276 indings suggest the degeneration of efferent/afferent thalamic projections and/or a neurodegenerative

277 he PVN, selective optogenetic stimulation of afferents that arise from these lamina terminalis AT1aR

278 part, from increased excitability of primary afferents that innervate the colon.

279 n of changes in glucose inflow through vagal afferents that require an activated glucagon-like peptid

280 y, rather than structural changes in primary afferents, that are responsible for alleviating hypersen

281 h (minimum number of branches to travel from afferent to efferent arterioles) is relatively independe

282 emniscal) and matrix (nonlemniscal) thalamic afferents to MMN generation.

283 a detailed functional assessment of the AON afferents to piriform in male and female C57Bl/6J mice.

284 ation of either glutamatergic or cholinergic afferents to probe the relative roles of different signa

285 Different afferents to the striatum can trigger dopamine signals,

286 relimbic (PrL) and infralimbic (IL) cortical afferents to the striatum triggers an increase in extrac

287 enetic stimulation of cortical glutamatergic afferents to the striatum triggers dopamine signals both

288 espective contribution of distinct prelimbic afferents to the temporal and contextual components of m

289 Group III/IV muscle afferents transduce nociceptive signals and modulate exe

290 erkel afferents; angular tuning of the other afferent types showed no clear alignment with mechanorec

291 ucleus of the solitary tract, which receives afferent vagal inputs.

292 ied account of dynamic spiking properties in afferent visual pathways.

293 Profiling of TL and LS bladder afferents was also performed.

294 In addition, transcriptionally, NG colon afferents were almost completely segregated from colon T

295 Visceral afferents were back-labeled using retrograde tracers inj

296 ivity in low threshold, presumably cutaneous afferents, whereas LAI and PAS require activity in (high

297 multitude of other cortical and subcortical afferents, which likely modulate its function.

298 We find that afferents with similar or differing preferred directions

299 from prehearing mice while stimulating MNTB afferents with stimulation patterns that mimicked those

300 ron microscopic analysis of the two Meissner afferents within the corpuscle supports a model in which