ライフサイエンスコーパス: afferent neuron

1 LPS which suppresses leptin effects on vagal afferent neurons.

2 essential nociceptive integrators in primary afferent neurons.

3 ation via activation of corneal cool primary afferent neurons.

4 ly compared MC4R-expressing vagal and spinal afferent neurons.

5 expression and hyperexcitability of bladder afferent neurons.

6 f injured and neighboring noninjured primary afferent neurons.

7 , cholinergic neurons, and intrinsic primary afferent neurons.

8 fluorescent protein in all Nav1.8-expressing afferent neurons.

9 ic and tonic discharge rates of postsynaptic afferent neurons.

10 changes in response properties of trigeminal afferent neurons.

11 K(ATP) channel current (IK(ATP)) in primary afferent neurons.

12 s have been identified on trigeminal primary afferent neurons.

13 vival and synaptogenesis in auditory sensory afferent neurons.

14 We investigated the role of CARTp in vagal afferent neurons.

15 ignaling might also affect extrinsic primary afferent neurons.

16 into the proximal urethra to label urethral afferent neurons.

17 cochlea is innervated by type I and type II afferent neurons.

18 or potential A1 (TRPA1) expressed in sensory afferent neurons.

19 ased in dorsal root ganglia-containing colon afferent neurons.

20 ic regulatory peptides at the level of vagal afferent neurons.

21 e cannabinoid 1 (CB(1)) receptor on group IV afferent neurons.

22 hypertrophy and hyperexcitability of bladder afferent neurons.

23 d by an indirect mechanism of stimulation of afferent neurons.

24 ed by neuromodulators acting directly on the afferent neurons.

25 B, NR2C, and NR2D) immunoreactivity in vagal afferent neurons.

26 tion by direct action on dissociated primary afferent neurons.

27 processes of intrinsic and extrinsic primary afferent neurons.

28 adder activity and the properties of bladder afferent neurons.

29 me-dependent inward I(h) currents in bladder afferent neurons.

30 ize than capsaicin-sensitive C-fiber bladder afferent neurons.

31 a maneuver that selectively excites group IV afferent neurons.

32 -1 receptors, expressed by enteric and vagal afferent neurons.

33 expressed in the intestine and by some vagal afferent neurons.

34 the immunohistochemical phenotype of primary afferent neurons.

35 SCI; however, changes were modest in bladder afferent neurons.

36 s suggested activation of similar subsets of afferent neurons.

37 nt neurons but is rarely observed in bladder afferent neurons.

38 using transganglionic labeling of vestibular afferent neurons.

39 beled from muscle were larger than cutaneous afferent neurons.

40 x differences in trigeminal ganglion primary afferent neurons.

41 in the expression of Na(v)1.8 in non-bladder afferent neurons.

42 o electrical signals that are relayed to the afferent neurons.

43 in the long-term survival of target-deprived afferent neurons.

44 rons, indicating heterogeneity among type II afferent neurons.

45 on terminals of trigeminal (TG) nociceptive afferent neurons.

46 hen transmitted with remarkable precision to afferent neurons.

47 n subepithelium, detrusor smooth muscles and afferent neurons.

48 associated prions entered the simian CNS via afferent neurons.

49 ctrical activity of TRPM8-expressing corneal afferent neurons.

50 and transmitted to the hindbrain via sensory afferent neurons.

51 t is expressed almost exclusively in primary afferent neurons.

52 ally distinct populations of spiral ganglion afferent neurons.

53 nd messenger RNA were expressed by cutaneous afferent neurons.

54 igeminal ganglion neurons and 30% of corneal afferent neurons.

55 enterochromaffin cells and intrinsic primary afferent neurons.

56 in-insensitive, mechanically sensitive vagal afferent neurones.

57 tion of TRPV1 may sensitize small intestinal afferent neurones.

58 diator that can excite and sensitize primary afferent neurones.

59 on between CCK and 5-HT in the vagal primary afferent neurones.

60 function of 5-HT3 receptors on gastric vagal afferent neurones.

61 kers of postganglionic sympathetic and vagal afferents neurons.

62 tic studies, ablation of capsaicin-sensitive afferent neurons abolishes bombesin-induced gastroprotec

63 reduced injury-induced activation of primary afferent neurons, activation of spinal neurons, and the

64 In spinal cord dorsal horn and in sensory afferent neurons, adenosine acts as a neuromodulator wit

65 and peripheral terminals of transduced vagal afferent neurons allowing for bright imaging of the nerv

66 these thermosensitive trigeminal orosensory afferent neurons also respond to capsaicin, menthol, and

67 and pharmacological responsiveness of vagal afferent neurones and fibres, although the effects of DI

68 otease-activated receptor 2 (PAR2) on spinal afferent neurons and cause persistent inflammation and h

69 on of retrograde tracing to identify corneal afferent neurons and double label in situ hybridization

70 However, the molecular identity of the afferent neurons and fibres mediating this reflex respon

71 Sensory signal transduction of the inner ear afferent neurons and hair cells (HCs) requires numerous

72 ease by keratinocytes activates both primary afferent neurons and immune cells to promote inflammator

73 stimulating CART and Y2R expression in vagal afferent neurons and in inhibiting food intake are augme

74 ive ion channel that is expressed on primary afferent neurons and is upregulated following inflammati

75 fewer stimulus-evoked action potentials from afferent neurons and loss of presynaptic Ca(V)1.3a calci

76 Our studies focused on primary afferent neurons and on their central targets in the spi

77 s in rodents show dopamine inhibits cochlear afferent neurons and protects against noise-induced acou

78 out the organization of their connections to afferent neurons and targets in the hindbrain.

79 detected between IB4- or ChTB-binding muscle afferent neurons and the total muscle afferent populatio

80 tion of nascent protein synthesis in primary afferent neurons and their axons.

81 s with functional sensitivity differences in afferent neurons and, in the case of inner hair cells of

82 d Adelta fiber DRG neurons including bladder afferent neurons, and might modulate activity of bladder

83 different cochlear elements (organ of Corti, afferent neurons, and stria vascularis) can degenerate i

84 ence for peripheral sensitization of primary afferent neurons, and there are no reports of persistent

85 ifferent classes of vagal and spinal primary afferent neurons, and underscore the role of the melanoc

86 the presynapse and stabilizing contacts with afferent neurons--and suggest that Ribeye plays an organ

87 These afferent neurones are activated by punctate mechanical s

88 Given that group IV afferent neurons are activated via chemically sensitive

89 also noted that TRPM8-IR or CGRP-IR corneal afferent neurons are almost entirely small and lack NF20

90 Piezo2 corneal afferent neurons are almost exclusively non-calcitonin g

91 Distinct clusters of IGL-afferent neurons are also located in the medial vestibul

92 heterogeneous population of ON- and OFF-type afferent neurons are combined to give rise to response s

93 Other IGL-afferent neurons are evident in Barrington's nucleus, th

94 Primary afferent neurons are functionally heterogeneous.

95 III) and metabolically (group IV) sensitive afferent neurons are important to this reflex in normal

96 CGRP(+) SP(-) afferent neurons are likely to be non-nociceptive.

97 Because human primary afferent neurons are not readily obtained, we sought to

98 with NeuN established that intrinsic primary afferent neurons are OTR-expressing.

99 Spinal afferent neurons are responsible for the transduction an

100 Vagal afferent neurons are therefore early integrators of peri

101 led that the majority of capsaicin-sensitive afferent neurones (both Adelta- and C-fibres) innervatin

102 , while Na(v)1.9 is expressed in non-bladder afferent neurons but is rarely observed in bladder affer

103 We performed RNA-seq on purified peripheral afferent neurons, but found no striking differences in g

104 ermines the neurochemical phenotype of vagal afferent neurons by regulating a switch between states t

105 oup of neuromasts, suggesting that different afferent neurons can convey information about receptive

106 e and intensity begins in the cochlea, where afferent neurons can fire action potentials at constant

107 Discovery of these afferent neurons capable of triggering hunger advances u

108 Because these afferent neurons carry sound information from the cochle

109 the expression of TTX-R channels in bladder afferent neurons changes after spinal cord transection,

110 odies are arrangements of intrinsic neurons, afferent neurons containing dense core vesicles, and sys

111 These results show that activity in primary afferent neurons contributes to ongoing SCI pain.

112 Inhibition of primary afferent neurons contributes to the antihyperalgesic eff

113 Primary afferent neurons convey somatosensory information to the

114 temporal progression of wave I amplitude of afferent neurons correlate with susceptibility and resis

115 development of wild-type fish, we found that afferent neurons could form specific synapses in the abs

116 elapsed before it became clear that visceral afferent neurons could themselves also be targets for gu

117 significantly larger in medium-sized bladder afferent neurons (diameter: 37.8 +/- 0.3 microm), a smal

118 Many auditory, vestibular, and lateral-line afferent neurons display spontaneous action potentials.

119 We investigated whether afferent neurons distinguish hair-cell polarities by ana

120 These results indicate that lateral-line afferent neurons do not require synaptic activity to dis

121 grade fluorescent labeling of dental primary afferent neurons (DPANs) has been described in rats thro

122 patch-clamp recordings, dissociated bladder afferent neurons exhibiting tetrodotoxin (TTX)-resistant

123 tion requires signals from extrinsic primary afferent neurons (ExPANs) located in spinal ganglia.

124 It is not clear whether primary afferent neurons express functional cell-surface opioid

125 y, these data indicate that group IV primary afferent neurons express multiple receptor defects in ca

126 Our results indicate that most vagal afferent neurons express NMDA receptor ion channels comp

127 of the study was to determine whether vagal afferent neurons express OX-R1 and OX-R2 and whether ore

128 We hypothesized that a proportion of corneal afferent neurons express Piezo2, and that these neurons

129 Depending on the nutritional status, vagal afferent neurons express two different neurochemical phe

130 The percentage of bladder afferent neurons expressing nNOS-IR was increased in L6

131 chlear potentials and changes in hair cells, afferent neurons, fibrocytes in spiral limbus and ligame

132 A subset of afferent neurons fired an action potential in response t

133 ulation to regenerate more axons than muscle afferent neurons following injury.

134 Neuromasts, and afferent neurons for both neuromasts and ampullary organ

135 erior lateral line of larval zebrafish, each afferent neuron forms synaptic contacts with hair cells

136 evoked currents in isolated, labelled muscle afferent neurons from control and heart failure (induced

137 hannels in the L6-S1 spinal cord and bladder afferent neurons from L6-S1 DRG in rats.

138 member 8 (TRPM8) transcripts in any corneal afferent neurons, further suggesting that Piezo2 is not

139 the NMDA receptor subunit phenotype of vagal afferent neurons has not been determined.

140 mechanisms responsible for activating these afferent neurons have yet to be identified.

141 In dye-labeled bladder afferent neurons, HCN-2-positive cells were found in app

142 acting at type 1 receptors (CCK1Rs) on vagal afferent neurons; however, CCK agonists have failed clin

143 ditory and vestibular sense organs and their afferent neurons; however, how auditory and vestibular f

144 The activity of individual afferent neurones in the mammalian cochlea can be driven

145 ance P-containing capsaicin-sensitive spinal afferent neurones in the upper thoracic (T1-T4) dorsal r

146 induced obesity locks the phenotype of vagal afferent neurons in a state similar to that normally occ

147 EA results in abnormal responses of group IV afferent neurons in cardiomyopathic rats.

148 lar recordings were made in vivo from A-type afferent neurons in cat L(6-7) DRGs.

149 r the mu-opioid receptor (muOR) into primary afferent neurons in dorsal root ganglia (DRGs) of rats,

150 form was also observed within muscle spindle afferent neurons in dorsal root ganglia with a higher pr

151 of the CB(1) and TRPv1 receptors on group IV afferent neurons in heart failure, we performed terminal

152 ay contribute to hypersensitivity of primary afferent neurons in irritable bowel syndrome patients.

153 Bladder afferent neurons in L1, L2, L6 and S1 dorsal root gangli

154 Primary afferent neurons in mammalian dorsal root ganglia (DRGs)

155 inergic (P2X) receptors are found in cranial afferent neurons in nodose ganglia and their central ter

156 Most vagal afferent neurons in rat nodose ganglia express mRNA codi

157 efective acidification of synaptic vesicles, afferent neurons in rbc3alpha mutants had reduced firing

158 of receptors and neuropeptides in rat vagal afferent neurons in response to CARTp was studied using

159 Chemogenetic stimulation of these afferent neurons in sated mice markedly activates AgRP n

160 robust spontaneous spiking from lateral-line afferent neurons in the absence of external stimuli.

161 NOS-IR was subsequently evaluated in bladder afferent neurons in the DRG and in the associated spinal

162 close apposition to the perikarya of primary afferent neurons in the MTN with a marked rostrocaudal g

163 cause MC4R is known to be expressed in vagal afferent neurons in the nodose ganglion (NG), we also sy

164 nnel that serves as a marker of the group IV afferent neurons in the periphery.

165 We examined the role of primary afferent neurons in the somatosensory cortical "reactiva

166 dentified discrete subpopulations of corneal afferent neurons in the trigeminal ganglion.

167 locity sensitivity of muscle spindle primary afferent neurons in the trigeminal mesencephalic nucleus

168 Additionally, activation of VTA afferent neurons in the ventral BNST and the infralimbic

169 eveal that birth order diversifies lateralis afferent neurons in the zebrafish.

170 s, indicating that AEA is acting on group IV afferent neurons in this preparation.

171 results we hypothesized the polarization of afferent neurons in upstream brain regions may modulate

172 Polarization of afferent neurons in upstream brain regions may modulate

173 iferate over the body surface, the number of afferent neurons increases linearly.

174 sed in apical and Cgrpalpha in basal type II afferent neurons, indicating heterogeneity among type II

175 ring RNA knockdown of TRPV4 in mouse primary afferent neurons inhibited the hypersensitivity caused b

176 Single neuronal discharges of vagal primary afferent neurones innervating the duodenum were recorded

177 We investigated whether primary afferent neurons innervating different regions of the lo

178 g an increase in excitability of the primary afferent neurons innervating the area.

179 dominantly expressed in medium-sized bladder afferent neurons innervating the bladder and that inhibi

180 Connections from intrinsic primary afferent neurons (IPANs), to ascending motor and interne

181 exus neurons thought to be intrinsic primary afferent neurons (IPANs).

182 t the reduced responsiveness in the group IV afferent neuron is an initiating factor in the developme

183 the characteristic frequency) of individual afferent neurones is invariant with intensity.

184 esponsiveness of CB(1) receptors on group IV afferent neurons is blunted in cardiomyopathy.

185 ween the membranes of the hair cells and the afferent neurons is conspicuously irregular and often in

186 Injury involving afferent neurons is discussed because of the relevance o

187 The release of SP from primary afferent neurons is increased during nociception, and SP

188 However, membrane mechanics of primary afferent neurons is largely unknown.

189 The action of gut hormones on vagal afferent neurons is now recognised to be an early step i

190 own whether information from haltere primary afferent neurons is sent to higher brain centers where s

191 One distinguishing feature of primary afferent neurons is their ability to bind the lectin IB(

192 These findings were recapitulated in primary afferent neurons isolated from dorsal root ganglia (DRG)

193 Co-expression of TGR5 and TRPA1 in cutaneous afferent neurons isolated from mice was analyzed by immu

194 Whole-cell patch-clamp recordings in vagal afferent neurons isolated from rat nodose ganglia demons

195 For small-diameter primary afferent neurons, it is unclear to what extent different

196 h is likely due to loss of PIEZO2 protein in afferent neurons leading to disturbed proprioception cau

197 in the inter-digestive period, inhibit vagal afferent neurons leading to increased food intake.

198 iosis may affect the excitability of primary afferent neurons, many of which are nociceptive.

199 s, unlike bladder afferent neurons, urethral afferent neurons may be hyperexcitable well into DM prog

200 Loss of GABA(B) receptors on primary afferent neurons may contribute to the development of me

201 electrophysiological properties of urethral afferent neurons may therefore contribute to voiding dys

202 profoundly affected by the states of primary afferent neuron mechanics.

203 Vagal afferent neurons mediate the effects of some gut signals

204 ulmonary mechanoreceptors indicates that the afferent neurones mediating cough are quite distinct fro

205 nd Drd2-Cre mice selectively labeled type II afferent neurons nearer the cochlear base.

206 Here we show that each afferent neuron of the posterior lateral line establishe

207 Elevating dopamine levels in beta'-afferent neurons of aged flies restores cold sensitivity

208 or subunit is present in a majority of vagal afferent neurons of nodose ganglia (NG), immunoreactivit

209 d the increase in P2X currents in the muscle afferent neurons of PAD rats.

210 undergo proliferation and differentiate into afferent neurons of the auditory and vestibular ganglia.

211 apoptosis of neuroepithelial hair cells and afferent neurons of the cochlea.

212 ining membrane mechanics of cultured primary afferent neurons of the dorsal root ganglia (DRG).

213 mMOR-1B4-LI was present in afferent neurons of the dorsal root ganglia and their pr

214 We show that the primary afferent neurons of the haltere's mechanoreceptors respo

215 oked action potentials (spikes) in hair-cell afferent neurons of the lateral line.

216 thermal and chemical sensitivity of primary afferent neurons of the pain pathway, but many aspects o

217 rning of tooth innervation by dental primary afferent neurons of the TG during organogenesis and prov

218 3 functions primarily in skeletal muscle, Ia-afferent neurons, or in Schwann cells that myelinate Ia-

219 etermined that abnormalities in the group IV afferent neuron population (associated with the metaboli

220 The percentage of cutaneous afferent neurons positive for SOM and IB4 exceeds that f

221 Group IV afferent neurons, primarily stimulated by the metabolic

222 dual retrograde tracing revealing that many afferent neurons project axon collaterals to both the la

223 troreceptive ampullary organs, innervated by afferent neurons projecting respectively to the medial a

224 Canal afferent neurons provide essential inputs to neural circ

225 PM8-mediated cold sensitivity on nociceptive afferent neurons provides a mechanism of cold allodynia.

226 Moreover, afferent neurons reassume their biased innervation patte

227 Single afferent neuron recordings from the lateral line reveale

228 Afferent neuron recordings revealed that hair cells with

229 ata indicate that the tracheal and laryngeal afferent neurones regulating cough are polymodal Adelta-

230 CK, GLP-1, PYY and ghrelin that act on vagal afferent neurons regulating food intake and autonomic re

231 Auditory information transfer to afferent neurons relies on precise triggering of neurotr

232 We propose that these airway afferent neurones represent a distinct subtype and that

233 Although information in tactile afferent neurons represented by firing rates has been st

234 Orosensory thermal trigeminal afferent neurons respond to cool, warm, and nociceptive

235 dorsal root ganglia (DRG) house the primary afferent neurons responsible for somatosensation, includ

236 ation by acting directly on TNFR1 in primary afferent neurons, resulting in p38-dependent modulation

237 Single cell RT-PCR on lung-specific vagal afferent neurons revealed that both TRPV1-expressing and

238 A single afferent neuron routinely contacts a group of neuromasts

239 c inhibition of transmitter release from the afferent neurons (S-cells) mediating the startle respons

240 The extrinsic primary afferent neurons send distress and other signals to the

241 body of evidence has demonstrated that vagal afferent neurones show non-uniform properties and that d

242 from directional or oriented motion, the T2 afferent neurons show clear motion orientation selectivi

243 nd the precise encoding of stimulus onset in afferent neurons.SIGNIFICANCE STATEMENT Numerous studies

244 hile squid exhibit peripheral alterations in afferent neurons similar to those that drive persistent

245 found in a subset of small-diameter, primary afferent neurones, some of which are also sensitive to c

246 e-related peptide (CGRP), and MOR in primary afferent neurons suggested an interaction of these pepti

247 eurotrophin3 (NT3), which is required for Ia-afferent neuron survival.

248 Afferent neurons target only one rostral or caudal locat

249 n and is more abundant on trigeminal primary afferent neurons than analogous extracranial neurons, ma

250 chemically distinct subpopulation of corneal afferent neurons that are not polymodal nociceptors or c

251 1 is expressed in a subpopulation of primary afferent neurons that express several different neurotra

252 neural tube, eventually differentiating into afferent neurons that form synaptic contacts with both e

253 regulation of efferent properties of primary afferent neurons that initiate neurogenic inflammation a

254 ctivation of CCK1 receptors (CCK1R) on vagal afferent neurons that innervate the gastrointestinal tra

255 gy to compare central projections of primary afferent neurons that innervate the masseter muscle and

256 ticipate in control of food intake via vagal afferent neurons that innervate the upper gastrointestin

257 To determine whether vagal afferent neurons that project to the stomach or duodenum

258 imately 70% of bladder and proximal urethral afferent neurons that send axons through the pelvic nerv

259 By retrograde labeling afferent neurons that target hindlimb skin, we showed th

260 he percentage of retrogradely labeled muscle afferent neurons that were CGRP-positive was greater in

261 ved to depend on activation of vagal sensory afferent neurones, the mechanisms involved in exciting t

262 to exist in both the dorsal horn and sensory afferent neurons, the expression profile of specific nuc

263 chanism at the first central synapse of lung afferent neurons, the nucleus tractus solitarius.

264 lucagon-like peptide-1 (GLP-1)) excite vagal afferent neurons to activate an ascending pathway leadin

265 tease-activated receptor 2 (PAR2) on primary afferent neurons to cause neurogenic inflammation and hy

266 fferential contributions of vagal and spinal afferent neurons to chemosensation and chemonociception.

267 st that TNFalpha may act directly on primary afferent neurons to induce pain hypersensitivity.

268 Cholecystokinin (CCK) acts on vagal afferent neurons to inhibit food intake and gastric empt

269 ich then acts at opioid receptors on primary afferent neurons to inhibit nociception.

270 The ratio of afferent neurons to neuromasts differs between the anter

271 orie-rich diets reduces sensitivity of vagal afferent neurons to peripheral signals and their constit

272 of sympathetic, parasympathetic, and spinal afferent neurons to quantify their relative contribution

273 from turtle vestibular hair cells and their afferent neurons to show that potassium ions accumulatin

274 duced obesity alter the sensitivity of vagal afferent neurons to stimulation as well as their pattern

275 pamine neurons, because removing NMDARs from afferent neurons to the ventral tegmental area (VTA) als

276 in activates intrinsic and extrinsic primary afferent neurons to, respectively, initiate peristaltic

277 reated (NNCAP) rats (rats that lack group IV afferent neurons) to determine whether administration of

278 ination of presynaptic inhibition of startle afferent neurons together with distributed postsynaptic

279 Primary afferent neurons transduce sensory information about tem

280 Thus, unlike bladder afferent neurons, urethral afferent neurons may be hyper

281 Excitatory, pain transmitting primary afferent neurons utilizing glutamate as an excitatory ne

282 To test the hypothesis that vagal afferent neuron (VAN) GLP-1 receptors (GLP-1Rs) are nece

283 Vagal afferent neuron (VAN) signaling sends information from t

284 with remarkable precision and efficiency to afferent neurons via specialized ribbon synapses.

285 etic and parasympathetic efferent and spinal afferent neurons, via axons in colonic nerve trunks.

286 of CART peptide (CARTp) from cultured vagal afferent neurons was determined by enzyme-linked immunos

287 Bladder afferent neurons were labeled with axonal transport of F

288 led by IB4, a marker of unmyelinated primary afferent neurons, were largely absent.

289 ganglia (DRG) contain cell bodies of primary afferent neurons, which are frequently studied by record

290 ility of mechanoceptive Adelta-fiber bladder afferent neurons, which are usually capsaicin-insensitiv

291 te membrane mechanical properties of primary afferent neurons, which provide, to our knowledge, a new

292 uli evoked smaller postsynaptic responses in afferent neurons, which rapidly fatigued.

293 is expressed in both bladder and non-bladder afferent neurons, while Na(v)1.9 is expressed in non-bla

294 as innocuous stimuli are detected by spinal afferent neurons, whose cell bodies lie in dorsal root g

295 Capsaicin-insensitive afferent neurones with cell bodies in the nodose ganglia

296 K+ currents was decreased by 52% in bladder afferent neurons with TTX-resistant spikes after 2 week

297 ffective and long-term transduction of vagal afferent neurons with viral vectors.

298 underlies the gut-brain axis, is via spinal afferent neurons, with cell bodies in dorsal root gangli

299 e medial organ of Corti and eventual loss of afferent neurons, with possible implications for human n

300 o organ of Corti), "primary" neural (loss of afferent neurons without loss of their hair cell targets