ライフサイエンスコーパス: against

1 ally, the algorithm's performance was tested against 10 ophthalmologists in a prospective clinic-base

2 (NT = nitrotriol), 2-nitro-1-propanol (NP)] against 5 different microbial pathogens including two an

3 Against a backdrop of increasing demand for mental healt

4 are reactivated during subsequent REM sleep against a backdrop of overall reduced ABN activity.

5 E interplay operates contingently within and against a backdrop of time and timescales.

6 enomic "islands" of elevated differentiation against a background of relative homogeneity.

7 m an Indian dromedary camel (ICab) immunized against a bacterial 14TM helix transporter, NorC, from S

8 zed by a broadly neutralizing human antibody against a broad range of H3N2 with high potency.

9 covariate, as measured on a selected scale, against a clinical outcome.

10 eurysm from CT angiograms (CTA) was compared against a generic 3-D U-Net and displayed superior resul

11 annotating whole-genome sequencing variants against a huge database with billions of genomic feature

12 inistered 24 h prior to infection, prevented against a lethal dose of HSV-2 infection in a murine mod

13 on based on measuring permutation importance against a null distribution.

14 hesized and tested for in vitro cytotoxicity against a panel of cancer cell lines.

15 creening of commercially available compounds against a panel of clinically relevant BLs: class A CTX-

16 Tested against a panel of GBM cell lines in vitro, paclitaxel w

17 F0045 is enantioselective against a panel of group 1 HAs and F0045(S) exhibits in

18 Comparison of CBP against a pulse wave analysis (PWA) device (Atcor Medica

19 and the results of calibration were compared against a reference scenario, which consisted of mobile

20 th cytotoxic evaluation of our designed ETPs against A549, DU 145, HeLa, HCT 116, and MCF7 human canc

21 lues to understanding how melatonin protects against Abeta, and that choice of chain perdeuteration i

22 both vaccines prevented fever and protected against abortion.

23 early all candidate inhibitors from a screen against acetylcholinesterase show detectable activity; b

24 acids, and flavonoid compounds were screened against acetylcholinesterase, butyrylcholinesterase, ure

25 ted whether TRV130 maintenance would protect against acute oxycodone-induced decreases in nucleus acc

26 gnaling, pathways responsible for protection against acute stressors.

27 or the advent of disease-modifying therapies against AD is imperative.

28 llular purines, adenosine and ATP, protected against ALI induced by purified LPS.

29 have precisely defined measures of security against all adversaries, human and/or machine.

30 The selected mvPC epitopes are homologous against all currently available annotated reference sequ

31 match molecular pairs, performed excellently against all tests and thus provides a valuable component

32 L1 and other ATG proteins mediate protection against alpha-toxin through the release of ADAM10 on exo

33 mmittees, the National Heart Institute opted against an explanatory diet trial and for a pragmatic mu

34 on of the MNK-eIF4E signaling axis protected against and reversed spontaneous pain and PNI-mediated c

35 ere evaluated using 10-fold cross-validation against annotations by expert surgeons.

36 monly used pyrethroid, by more than 10 times against Anopheles mosquitoes.

37 ntroduces DNA origami as a tool in the fight against antibiotic resistance, and our results demonstra

38 us agent in peritonitis, and suggest caution against anticoagulants in individuals susceptible to per

39 >= 20 U/mL) conferred substantial protection against any and severe rotavirus gastroenteritis to age

40 gether with the opportunity to design probes against any sequenced genome.

41 an initially protective autoimmune response against apoB with a progressive derangement in clinical

42 d in BALB/c nude mice and highly efficacious against AR42J tumors in vivo.

43 auditory neurons accelerated - or protected against - ARHL.

44 All patients had reactive T cells against at least 1 of 12 analyzed viral Ags, and all pat

45 mechanistic basis of this endogenous defense against atherosclerosis.

46 ned molecular dynamics simulations validated against atomistic simulations, we explore the molecular

47 explore with respect to modulating responses against autoantigens and alloantigens after kidney trans

48 may confer protection to neighboring yeasts against azoles, in turn strengthening their co-existence

49 was still enforced, and there was selection against B cells with high affinity for self-antigen.

50 d BPZE1 vaccine candidate induces protection against B. pertussis and prevents nasal colonization in

51 rived region of chromosome 11 that protected against B6.Y (POS) sex reversal.

52 on in the apicoplast; mimicking its activity against bacteria.

53 ovorax avenae, naringenin was more effective against bacterial pathogens and sakuranetin was more eff

54 entral element of the defense of the airways against bacterial pathogens.

55 or binding to ProQ and negative determinants against binding to Hfq.

56 l activity of the eight identified compounds against BIRFLU was further confirmed with seasonal IAVs

57 stic performance of select clinical features against blood culture results among outpatients using mi

58 matergic neurons is necessary for protection against body weight gain and induction of UCP1 in adipos

59 reinforcement learning model, were regressed against BOLD signal.

60 (Pd1-/-) demonstrated remarkable protection against bone destruction induced by femoral inoculation

61 anisms as well as generic defences effective against both Ma549 and E. muscae.

62 hway is required for PIV-mediated protection against C. burnetii infection.

63 n trimethoprim exhibited increased virulence against Caenorhabditis elegans.

64 t I(SOC) and protect the endothelial barrier against calcium entry-induced disruption.

65 signed a new chemotherapeutic drug candidate against cancer, namely, [Ru(DIP)(2)(sq)](PF(6)) (Ru-sq)

66 ored the activity of beta-lactam antibiotics against carbapenem-resistant Pseudomonas aeruginosa and

67 nt was found to have anti-retinal antibodies against carbonic anhydrase II and enolase proteins with

68 arguable that diets with protective effects against cardiovascular disease exert an anti-atherothrom

69 of (89)Zr-IAB22M2C, a radiolabeled minibody against CD8+ T cells, for targeted imaging of CD8+ T cel

70 ponses, which provide far greater resistance against challenge with nontyphoidal serovar Salmonella E

71 f acalabrutinib with or without obinutuzumab against chlorambucil with obinutuzumab in patients with

72 he development of new therapeutic strategies against chronic CHIKV disease.

73 s Enterobacteriaceae with a growth advantage against competitors in the inflamed gut.

74 cal regression to compare this VDP threshold against conventional clinical measures as predictors of

75 ectrum prophylactic and therapeutic activity against currently circulating influenza viruses in human

76 m-negative bacteria functions in the defense against cytotoxic substances, such as antibiotics.

77 sitization, and resulted in cross-protection against different allergens.

78 eir relative co-benefits with and trade-offs against different social and environmental goals have be

79 osing or combination of CAR T cells directed against different targets, and decreased cost using an i

80 l memory able to induce long-term protection against disease.

81 on bioactive ingredients in order to protect against diseases and to develop healthy diets.

82 r phases, provokes systemic T cell responses against dominant and subdominant neoantigen epitopes der

83 esters showed radical scavenging activities against DPPH radical and ABTS radical cation.

84 VO showed the highest antimicrobial activity against E. coli, S. aureus, and S. typhi in in vitro ant

85 he development of antidrug antibodies (ADAs) against each of the DART molecules.

86 tion but it has no direct antiviral activity against ECTV.

87 devices were extracted for later comparison against EEG to determine degrees of accuracy.

88 he antibacterial activities of the compounds against efflux-deficient Escherichia coli are mediated b

89 e-site pocket, contributes to discrimination against eG.

90 The 2016 ISTH guidance against elective pregnancy termination for fear of DOAC

91 esting stages in the formation of a "buffer" against elevated temperatures.

92 red adequate for redirected killing activity against Env-expressing target cells but began to decline

93 Robustness against environmental fluctuations within an adaptive st

94 f horses and developed a therapeutic vaccine against equine IL-31 (eIL-31).

95 for new therapeutic interventions, directed against evolving resistance.

96 atom structure-based simulations, calibrated against explicit solvent simulations, were employed for

97 at provide sustainable responses and buffers against extreme environmental conditions.

98 ) could be considered as a protective factor against FA, but its mechanisms remain unclear.

99 vestigated the therapeutic potential of IL-4 against fatal malaria in Plasmodium berghei ANKA-infecte

100 e Fatigue Risk Management Systems to protect against fatigue in nurses, midwives, and other shift wor

101 f IgM-anti-FceRIalpha, but not of IgG or IgA against FceRIalpha, were linked to low blood basophil (r

102 cancer cells, ether-lipid synthesis protects against ferroptosis.

103 ines (ETPs) and evaluation of their activity against five human cancer cell lines.

104 timate the frequency of FA and sensitization against food allergens in primary school children in eig

105 y-dependent cell-mediated cytotoxic activity against FRalpha is also associated with prolonged RFS.

106 pathogens and sakuranetin was more effective against fungal pathogens.

107 cytokine IL-17F contributes to host defense against fungi.

108 able increase of functional immune responses against GBS compared to the simple co-administration of

109 ty of isolating recombinant phage-antibodies against gluten from a non-immunized library of human sin

110 Their role in plant immunity against hemibiotrophic fungal infection remains poorly u

111 old higher in vitro activity than ivermectin against hepatic and blood stage infections, respectively

112 the goal of inducing resistance above ground against herbivorous insects.

113 s might represent a novel therapeutic target against HIV-1 infection and HIV-associated neurological

114 h to inform curative and preventive measures against HIV/AIDS.

115 sequently, TEC-derived LXRalphabeta protects against homeostatic premature involution and orchestrate

116 d-stage parasite exposure impacts protection against homologous controlled human malaria infection.

117 s been shown to be both safe and efficacious against HSV-2 and HIV-1 infections in vivo.

118 s of broadly neutralizing antibodies (bnAbs) against human immunodeficiency virus (HIV).

119 the absence of a correlate(s) of protection against human tuberculosis and a validated animal model

120 opment of improved vaccines and therapeutics against IBVs.

121 a bioluminescence-based assay was developed against IFN-gamma and provided an optimized, physiologic

122 We first validated blood flow simulations against in vitro measurements in 3D-printed phantoms rep

123 glycan cap of GP1 may allosterically protect against inactivation of EBOV by premature triggering of

124 Indeed, mecA protects the bacteria against increased cell-envelope permeability under subin

125 presents an important host defence mechanism against infection in neonates.

126 otube transfer of GNLY allows dNK to protect against infection while leaving the maternal-fetal barri

127 l metabolism impacts innate immune responses against infection.

128 en exposure can confer long-lived protection against infections or tumors.

129 mune cells of the CNS, are thought to defend against infections.

130 n-specific antibodies that can be protective against infectious agents exhibiting the same carbohydra

131 , in vivo, we have investigated its efficacy against infectious bronchitis using a broiler infection

132 therapeutic benefit of monoclonal antibodies against infectious disease agents may be debatable, the

133 c ER kinase (PERK) protects oligodendrocytes against inflammation in the experimental autoimmune ence

134 ibodies (M2e-MAbs) show protective potential against influenza A, however, they are either strain spe

135 of which have been implicated in protection against influenza, have yet to be defined.

136 mmune response of the elderly to the vaccine against influenza.

137 ntly ameliorates glucose tolerance, protects against insulin-resistance onset and remarkably reverses

138 ticipating in a trial comparing IPTp with SP against intermittent screening by rapid diagnostic tests

139 s are known to provide a competitive barrier against invading bacterial pathogens in the intestinal t

140 sruption of the defense mechanism in mammals against invading pathogens.

141 in-based vaccine that is licensed to protect against invasive group B meningococcal disease.

142 as performed to investigate if UDCA protects against ischaemia-induced and reperfusion-induced arrhyt

143 r the other two procedures should be weighed against its significant association with postoperative u

144 s possible to develop a prophylactic vaccine against LF.

145 hat the surface states in ZrTe(5) are robust against Li adsorption.

146 amically stable with a high interface energy against Li, and they should have a low electronic conduc

147 Performance of the ANN was evaluated against logistic regression and the standard grading sys

148 ion of chromatin loops by protecting cohesin against loop release.

149 ances immunogenicity and protective efficacy against M. tuberculosis challenge.

150 e immune cells essential for host protection against malaria.

151 lular bacterial infections but is protective against malarial toxin hemozoin.

152 ween the activity of the donor immune system against malignant and nonmalignant cells of the recipien

153 Functionalized drug delivery systems against malignant lung metastasis of breast cancer have

154 ssociated CdiA-CT domain to promote toxicity against mammalian cells in culture and lethality during

155 has been shown to have bactericidal activity against many pathogens, including Pseudomonas aeruginosa

156 d as a potential key mechanism of protection against many viral pathogens, antibodies mediate additio

157 there are no efficacious drugs and vaccines against MERS-CoV, increasing its potential to cause a pu

158 Thus, our data argue against mHTT crossing the MOM and entering into the mito

159 IT) cells are important for immune responses against microbial infections.

160 C-terminus is required for hGBP1's activity against microbial pathogens, as well as for its antiprol

161 In the constant evolutionary battle against mobile genetic elements (MGEs), bacteria have de

162 cific cytokine responses that are protective against mortality during experimental sepsis.

163 pper ions, are effective bactericidal agents against MRSA.

164 y, which confers protective trained immunity against Mtb.

165 S) exhibits in vitro neutralization activity against multiple H1N1 and H5N1 strains.

166 Second, we quantitatively test model against multiple leaf gas-exchange datasets.

167 f the order of -1 degrees C, performing well against multiple reconstructions of surface temperature

168 standard genetic code, providing robustness against mutations that increase carbon and nitrogen inco

169 ation process provides an effective strategy against MXene oxidation by restricting the interaction o

170 Neurological disorders with IgG antibodies against myelin-oligodendrocyte glycoprotein (MOG-IgG) ha

171 anofin exhibited rapid bactericidal activity against N. gonorrhoeae.

172 ential of solenopsins as novel natural drugs against neglected parasitic diseases caused by kinetopla

173 g in myeloid cells was sufficient to protect against nephritis.

174 n RA human synovial tissues frequently react against NETs.

175 cts in intracellular survival and protection against neutrophil killing.

176 used to create the nanolenses, can mitigate against non-specific, adventitious nanoparticle binding,

177 AML patients, while showing no cytotoxicity against normal PBMCs, NIH3T3, and HEK293 cells.

178 er membrane serves as a permeability barrier against noxious compounds in the external environment.

179 has been shown to have anti-tumour activity against NTRK gene fusion-positive solid tumours, includi

180 , viperin has been shown to possess activity against numerous viruses via multiple proposed mechanism

181 d for a 4 to 8 times larger projected impact against obesity than would be achieved though reformulat

182 T cells associated with protective immunity against ocular herpes infection and disease.IMPORTANCE W

183 that was associated with protective immunity against ocular herpes.

184 ng bacterial defense and survival strategies against one of the most powerful neutrophilic oxidants m

185 ling and integrate specific global responses against opportunistic bacteria to combat microbial incur

186 hallenge regarding how to prioritize typhoid against other emerging diseases.

187 ny and cell morphology, motility, antagonism against other microbes, and biofilm formation.

188 a and demonstrates a highly predictive skill against our test datasets.

189 rotecting highly unsaturated oils such as FO against oxidation.

190 from SAE, protected ROS-exposed Caco2 cells against oxidative (78%) and cellular (90%) damage at a 3

191 mitochondrial oxidative capacity may protect against oxidative stress associated with birth while ens

192 s capacity for providing cellular protection against oxidative stress while serving as a reactive oxy

193 method for fosfomycin susceptibility testing against P. aeruginosa and stress the need for P. aerugin

194 based oncolytic viruses are promising agents against pancreatic ductal adenocarcinoma (PDAC).

195 These cross react against parental, unmodified tumors and lead to a high r

196 o compare its efficacy with the bulk extract against pathogenic bacteria.

197 strong humoral and cellular immune responses against pathogenic Ebola viruses and support further eva

198 pave the way for immunogen design to protect against pathogenic hantaviruses.

199 key immune effectors that confer protection against pathogenic threats.

200 ng effective cytotoxic and humoral responses against pathogens.

201 on may be an effective preventative strategy against pathologic inclusion formation.

202 s, that provide sequence-specific protection against phage infection.

203 a elimination, while weighing these benefits against potential risks of chemoprevention.

204 arthropods, and suggest a defensive strategy against predation, previously only known from trilobites

205 elicited mutation-specific T cell responses against predicted neoepitopes not detected before vaccin

206 a significant mediator of cardiac protection against pressure overload-induced pathological cardiac h

207 We validated our model against previous estimates of YF basic reproductive numb

208 size, locality, pre-intervention achievement against primary outcomes, total quality scores, and leve

209 ldren with the development of autoantibodies against (pro)insulin in early childhood.

210 signaling was essential for host resistance against pulmonary Aspergillus fumigatus challenge throug

211 ed a naive human semisynthetic phage library against RBD, leading to the identification of a high-aff

212 d showed that the IgM, A, and G Ab responses against receptor-binding domain are significantly correl

213 eptor (VNAR) was used for in vitro selection against recombinant human TfR1 ectodomain (rh-TfR1-ECD)

214 CAR-T cells have shown encouraging activity against recurrent and refractory diffuse large B cell ly

215 th SARS-CoV-2 results in protective immunity against reexposure.

216 al infection, promotes healing, and protects against reinfection.

217 ith an endpoint geometric mean titer of ~415 against replicative virus, comparing favorably with seve

218 tivities of two recombinant human SP-D forms against representative LPAIV strains, including H2N1, H5

219 e conclude that SIM regimes for immunization against respiratory pathogens warrant further study.

220 erdefense mechanism to protect their genomes against restriction.

221 for HMPV and only one prophylactic treatment against RSV, palivizumab, for high-risk infants.

222 oid acids with potent anti-virulence effects against S. aureus.

223 l activities were also promising, especially against Salmonella typhimurium (MBC = 0.44 mg/mL).

224 era exhibited specific neutralizing activity against SARS-CoV-2 and SARS-CoV-2 S pseudotypes.

225 ell as CD8(+) T cell responses, and protects against SARS-CoV-2 infection in the lungs and noses of m

226 T cell reactivity against SARS-CoV-2 was observed in unexposed people; how

227 Neutralising antibody responses against SARS-CoV-2 were detected in 32 (91%) of 35 parti

228 of the US adult population formed antibodies against SARS-CoV-2, and fewer than 10% of those with ant

229 sensor for immunoglobulin detection produced against SARS-CoV-2.

230 ntial therapeutic and/or prophylactic agents against SARS-CoV-2.

231 sting the prophylactic effectiveness of IFNs against SARS-CoV-2.

232 in regulating GSC division frequency, RNA-i against seven out of 35 G-protein coupled receptors (GPC

233 ne of these analogues has excellent activity against several streptogramin-resistant strains of Staph

234 ly human, neutralizing monoclonal antibodies against severe acute respiratory syndrome coronavirus 2

235 Antibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus 2

236 pulations may contribute to reduced efficacy against severe rotavirus disease.

237 re analyzed for PGE(2) levels and correlated against severity; 9alpha,11beta-PGF(2) and PGI(2) metabo

238 emonstrates remarkable discrimination of DON against similar mycotoxins (zearalenone and ochratoxin A

239 eterminants of CD8+ T cell-mediated efficacy against SIV.

240 have canopy-scale measurements been assessed against soil measurements in the tropics.

241 p6p utilizes its selectivity to discriminate against specific RNAs.

242 nhibition by ouabain), a significant advance against state of the art cell based sensors.

243 Dorsal root ganglia nociceptors protect against STm colonization, invasion, and dissemination fr

244 ly relevant polysaccharide conjugate vaccine against Streptococcus pneumoniae (pneumococcus).

245 tured by a continuum model of biofilm growth against substrate friction.

246 rmality, and to measure any surgical changes against such a personalized benchmark.

247 Unfortunately, proposed countermeasures against such attacks have failed to be effective, as the

248 The model was validated against surgical data.

249 ication of immunoglobulin G (IgG) antibodies against T. gondii embryogenesis-related protein (TgERP).

250 DISC1), is involved in host immune responses against T. gondii infection.

251 RI acquisitions and evaluate its performance against that of conventional image upscaling methods.

252 y HI were higher than those determined by MN against the A/H3N2 strain.

253 e observed mechanism seems to be a safeguard against the accumulation of dysfunctional CI arising fro

254 feeding modulates infant growth and protects against the development of obesity.

255 protective capacity of the endogenous virus against the exogenous form, either via direct interferen

256 the antiviral activity of natural compounds against the following influenza virus strains: A/WSN/33

257 thin (L) were evaluated for their inhibition against the formation of lipid hydroperoxides and carbon

258 s, but an additional 20% of proteins matched against the full Arabidopsis proteome, indicating a uniq

259 The method was validated against the gold standard Limulus Amoebocyte lysate assa

260 mechanisms that are beneficial in defending against the haemorrhagic insult.

261 cellent reservoirs to host organic compounds against the harsh surface conditions of Mars.

262 Investigations of antiviral activity against the human respiratory syncytial virus were carri

263 re critical for early priming of CD8 T cells against the immunodominant TMEV peptide VP2(121-130) Los

264 uman naive and memory CD4+ T cell repertoire against the influenza pandemic H1 hemagglutinin (H1-HA).

265 the measured ratios of the MS ion responses against the known spiked-in ratios (CVs < 8% for calibra

266 ptor-binding domain (RBD) and those directed against the N-terminal domain (NTD), indicating that bot

267 A-signalling is required for potato defences against the necrotrophic fungal pathogen Alternaria sola

268 signalling, is required for potato defences against the necrotrophic pathogen A. solani.

269 NOD mouse model of T1D produce Abs directed against the neuronal type III intermediate filament prot

270 es in serum and cerebrospinal fluid directed against the nuclei of Purkinje cells, striatal neurons,

271 rapeutic approach for selectively protecting against the pathologic actions of Abeta in AD.SIGNIFICAN

272 about equally divided between those directed against the receptor-binding domain (RBD) and those dire

273 nogens induced robust neutralizing responses against the respiratory syncytial virus.

274 ultaneously activates pre-emptive protection against the second impending challenge.

275 This introduces a paradox which goes against the second law of thermodynamics that states how

276 ay of around 4 months, protecting antibodies against the short L1 appeared, enabling the virus to suc

277 are formed while the filter paper is pressed against the substrate.

278 Background Guidelines recommend against the use of intravenous tPA (tissue-type plasmino

279 )D or 25(OH)D metabolites with T2D and argue against the use of vitamin D supplementation for the pre

280 ed routinely in antimalarial drug discovery, against the whole organism.

281 mphoma patients exhibited improved responses against their autologous lymphomas.

282 The main line of cellular defense against these electrophilic molecules is conjugation to

283 Effective countermeasures against these viruses are highly desired.

284 id in the development of more specific drugs against this target.

285 d the performance of exchange plus treatment against treatment alone by modeling establishment rates

286 n-dependent manner and demonstrated activity against Trypanosoma brucei rhodesiense bloodstream forms

287 ese APECs redirect pre-existing CMV immunity against tumor cells in vitro and in mouse cancer models.

288 mor clearance and subsequent full protection against tumor rechallenge in 33% of nanoformulated CCL21

289 nexpectedly, early priming of CD4(+) T cells against tumour-derived antigens also required cDC1, and

290 sts with one, two, or even three antibiotics against two clinically isolated multi-drug-resistant bac

291 coupled with immunofluorescence experiments against tyrosine hydroxylase (TH) or dopamine transporte

292 e ingredients for the protection of the skin against UVR.

293 We found significant VE against vaccine-type CIN2+ after 3 doses of HPV vaccine

294 point inhibitors are already used as therapy against various cancers, not much is known about their m

295 NVS-CECR2-1 exhibits cytotoxic activity against various human cancer cells, killing SW48 colon c

296 will further enhance current tumor therapies against various malignant solid tumors, including drug-r

297 e formation is an effective defense strategy against viral-mediated mortality.

298 h the MAVS adaptor to activate IFN responses against viruses.

299 storage, respectively) and protected the oil against volatile compound formation (heptanal, (E,E)-2,4

300 at APP is a restriction factor that protects against ZIKV by serving as a decoy receptor, and plays a