ライフサイエンスコーパス: age-related change

1 hat incentive processing should also undergo age-related change.

2 ntify spatial patterns demonstrating similar age-related change.

3 ing of rewards and costs undergo substantial age-related changes.

4 ous system and displays neurodevelopment and age-related changes.

5 ral stem cells being especially sensitive to age-related changes.

6 ntal conditions may accelerate or potentiate age-related changes.

7 lly-curated and readily accessible source of age-related changes.

8 y properties, appears ideal for easing these age-related changes.

9 ell, CD8 and CD4 subpopulations demonstrated age-related changes.

10 k throughout adulthood prevent most of these age-related changes.

11 f the murine biomarkers in DMD, with similar age-related changes.

12 tum, with the latter being more sensitive to age-related changes.

13 rmation is accumulating about infections and age-related changes.

14 pan, chimpanzees did not display significant age-related changes.

15 ) as a reference control for the appropriate age-related changes.

16 cortical thickness measurements sensitive to age-related changes.

17 Before accounting for age-related change, 50.0% (75 eyes) showed progression b

18 Are these age-related changes amenable to genetic manipulations th

19 rieval and to understand the neural basis of age-related changes and individual differences in the ca

20 he margins of GA are less affected by normal age-related changes and reflect FD alterations related t

21 rinsic and extrinsic factors impact observed age-related changes and sex-related differences in skele

22 However, possible age-related changes and their associated underlying neur

23 We found that these age-related changes are associated with the repression o

24 ntralized resource in which data on multiple age-related changes are collated.

25 However, age-related changes are likely multifactorial, and the r

26 ome-wide patterns of DNA methylation so that age-related changes are profoundly delayed, while change

27 It is unclear whether these age-related changes are secondary to decreases in region

28 process, and demonstrate that most of these age-related changes are, by their fundamental nature, re

29 as their aortas and kidneys revealed typical age-related changes (arteriosclerosis and glomeruloscler

30 Age-related changes associated with metabolic disturbanc

31 mpared with young wild-type mice and greater age-related changes at 12 to 13 months of age.

32 in the SVZ declines through aging; however, age-related changes attributable specifically to the SVZ

33 to aging processes in joint tissues, but the age-related changes being discovered certainly could pla

34 is age reset requires novel methods to mimic age-related changes but also offers opportunities for st

35 Age-related changes can also be linked to each other in

36 integrity during adulthood and show that its age-related changes can be rescued by a TIE2 agonistic a

37 However, underlying health status and age-related changes can have an impact on tolerance of h

38 This study examined age-related changes, gender differences, and the interac

39 t study was twofold: (1) to test patterns of age-related change (i.e., linear, quadratic, and cubic)

40 These age-related changes impact older transplant candidates a

41 determine the mechanism responsible for the age related change in B-1a cell IgM, we established a mi

42 The present study addressed the age related changes in expression and distribution of or

43 These data shed light on the nature of age related changes in reaching-to-grasp movements and e

44 of decline of lung function is greater than age-related change in a substantial proportion of patien

45 inguish between biological and chronological age-related change in arterial health in humans.

46 We found 2 distinct modes of age-related change in FC: "conservative" and "disruptive

47 eft heart morphology over time suggests less age-related change in H2RA users.

48 ecipients prevented sarcopenia and prevented age-related change in muscle fiber phenotype.

49 However, there was no evidence of age-related change in Ricco's area for either achromatic

50 Twin studies show that age-related change in symptoms of attention-deficit/hype

51 There is no age-related change in the cross-sectional area of the fo

52 mously and others of which are imposed by an age-related change in the local milieu or systemic envir

53 Here, we identify an age-related change in the temperature preference of adul

54 We tested the hypothesis that age-related change in waist circumference (to reflect ce

55 Raman spectroscopy can identify and quantify age-related changes in a single nondestructive measureme

56 Moreover, age-related changes in Abeta oligomers and tau phosphory

57 Age-related changes in amygdala functional connectivity

58 analysis was used to evaluate positional and age-related changes in angle morphology.

59 The age-related changes in behaviour and dendritic spine den

60 leus (SCN), relatively little is known about age-related changes in Bmal1 expression in other tissues

61 ases significantly with age, coinciding with age-related changes in body composition that are common

62 Age-related changes in bone microstructure and strength

63 We discovered distinct age-related changes in both model organisms.

64 by nestin gene regulatory elements to define age-related changes in both numbers of satellite cells t

65 dress this question, herein we characterized age-related changes in both the transcriptome and transl

66 trajectory of brain development, reflecting age-related changes in brain excitability.

67 Understanding the relationships between age-related changes in brain structure and cognitive fun

68 Preliminary data showed no substantial age-related changes in brentuximab vedotin pharmacokinet

69 d plasticity, and this could in part reflect age-related changes in Ca2+ homeostasis.

70 The molecular factors that regulate age-related changes in cardiac physiology and contribute

71 d cardiovascular mortality but its effect on age-related changes in cardiac structure and function is

72 nes the effect of daily physical activity on age-related changes in cardiac structure, function, meta

73 mes of ageing can now be delayed or reduced, age-related changes in cellular, molecular and physiolog

74 that APOE epsilon4 carriers showed stronger age-related changes in cerebrospinal fluid phosphorylate

75 Together, our data reveal multiple age-related changes in chromosome architecture that coul

76 Age-related changes in circadian rhythms may contribute

77 These data support age-related changes in CNI metabolism.

78 resent a pilot study illustrating how normal age-related changes in cognition and the linguistic cont

79 These findings suggest that even very subtle age-related changes in cognition have detrimental effect

80 l and longitudinal study in order to address age-related changes in community-dwelling individuals.

81 apacity with aging but has limited effect on age-related changes in concentric remodeling, diastolic

82 Developmental and adult age-related changes in cortical thickness followed close

83 Age-related changes in crowding may in part explain slow

84 literature, our tentative conclusion is that age-related changes in CSF circulatory physiology and th

85 KEY POINTS: Age-related changes in cutaneous microvascular and cardi

86 these responses are maximally restrained by age-related changes in cutaneous microvascular and cardi

87 e examination of one potential substrate for age-related changes in decision-making, namely age-relat

88 on melanoma progression, we examined whether age-related changes in dermal fibroblasts could drive me

89 Previous studies have demonstrated age-related changes in detrusor function and urothelial

90 extent of, and interindividual variation in, age-related changes in DNA methylation at specific CpG i

91 ion patterns, leading to the hypothesis that age-related changes in DNA methylation may partially und

92 DR is generally strongly protective against age-related changes in DNA methylation.

93 NF- and GABA-related genes exhibited similar age-related changes in DNAm and correlation with gene ex

94 However, Shc proteins did not influence age-related changes in energy expenditure or RQ.

95 Here, we investigated the age-related changes in epidermal Langerhans cells (LCs),

96 Studies examining the age-related changes in expression of these proteins have

97 g have identified subsets of genes that show age-related changes in expression.

98 erations in colonic 5-HT signalling underlie age-related changes in faecal output in mice and whether

99 A simulation model was developed to predict age-related changes in foraging energetics of individual

100 development of posterior alpha power whereas age-related changes in frontal theta power deviated from

101 ptional profiling using RNA-Seq revealed few age-related changes in gene expression in muscle and eso

102 ging studies have associated such decline to age-related changes in general cognitive-control network

103 To provide insight into age-related changes in gut microbiota that may underlie

104 lls (HSCs) are thought to be responsible for age-related changes in haematopoiesis that include a dec

105 Age-related changes in HC, height, and weight between bi

106 not a statistically significant predictor of age-related changes in HDL-cholesterol, triglyceride, in

107 investigated putative mechanisms underlying age-related changes in homeostatic regulation of CD4+ na

108 Here, we systematically investigated age-related changes in homotopic RSFC in 214 healthy ind

109 lammaging") has been proposed as a driver of age-related changes in HSC function and myeloid malignan

110 We argue that age-related changes in HSCs and in the hematopoietic sys

111 In this study, we explored age-related changes in human immunity during a primary v

112 Age-related changes in immune regulation are likely to a

113 and discuss a conceptual framework in which age-related changes in immunity might also affect the ba

114 objective of this study was to characterize age-related changes in immunologic profiles according to

115 We compared age-related changes in inner hair cells (IHCs) between f

116 Age-related changes in lens elasticity and ciliary muscl

117 mporal dynamics and structural correlates of age-related changes in lexical-semantic processing.

118 molecular and cellular changes of aging with age-related changes in lung physiology and disease susce

119 There are indications that at least some age-related changes in lymphopoiesis may be reversible.

120 We examined whether age-related changes in mammographic density were differe

121 nding proteins, and to determine gestational age-related changes in maternal and fetal plasma FA conc

122 Age-related changes in maternal reproductive allocation

123 Age-related changes in maternal resource allocation to r

124 Age-related changes in MCT, CVV, CSV, and CVI were studi

125 ations of mitochondria from mouse liver show age-related changes in membrane morphology.

126 ions in the hippocampal network that predict age-related changes in memory function and present poten

127 However, it is unclear if these age-related changes in microvascular and cardiac functio

128 In addition, we present evidence of age-related changes in mitochondrial Ang receptor expres

129 S generation), and whether exercise reverses age-related changes in mitochondrial function.

130 escribe the effect of light level on normal, age-related changes in monocular and binocular functiona

131 We evaluated age-related changes in mouse hearing by recording audito

132 Taken together, these data suggest that age-related changes in MSC population dynamics result in

133 dial temporal lobe (MTL) in episodic memory, age-related changes in MTL structure and function may pa

134 Microarray analysis revealed age-related changes in multiple genes, including some wi

135 for this group is that they are experiencing age-related changes in multiple organ systems, including

136 thritis occurs in older adults who also have age-related changes in muscle, bone, fat, and the nervou

137 ated tau 181/beta-amyloid 42 levels modulate age-related changes in myelin water fraction.

138 f >/= 30 kg/m(2), enhanced the expression of age-related changes in N glom in African Americans with

139 ry accuracy and reduce the commonly observed age-related changes in neural activity associated with s

140 analysis of early signs of pathological and age-related changes in neurogenesis, evaluation of speci

141 this way, the model was modified to reflect age-related changes in neuromuscular function.

142 Nonetheless, age-related changes in neuron number do occur in focal r

143 e conclude that the general distribution and age-related changes in neuropeptides indicate a modulato

144 Here we aimed to (1) characterize the age-related changes in nigral dopaminergic neurons in th

145 d (2) What are the predicted consequences of age-related changes in norepinephrine signaling for cogn

146 In humans, age-related changes in personality occur in a non-random

147 acrophage TLR2 or FcgammaRIII expression, or age-related changes in phagocytic potential and bacteric

148 Concentrations changed with age, suggesting age-related changes in phthalate exposure and perhaps me

149 These data suggest that the accumulation of age-related changes in promoter-associated CpG islands m

150 years) adults, we tested the hypothesis that age-related changes in RBC deformability (Study 1) and c

151 igated whether crowding also plays a role in age-related changes in reading speed.

152 is review, we summarize published results on age-related changes in response to infection with the in

153 nificant alterations in linear and nonlinear age-related changes in resting oscillatory power and net

154 ncephalography study aimed at characterizing age-related changes in resting-state functional brain or

155 spectrum and other psychopathology groups in age-related changes in resting-state functional MRI amyg

156 computational approach, we demonstrate that age-related changes in reversal-learning performance in

157 Moreover, this typical age-related changes in rich-club organisation were chara

158 ung and aged memory-impaired rats to examine age-related changes in ripple architecture, ripple-trigg

159 n rPPC grey matter volume better account for age-related changes in risk preferences than does age pe

160 We also measured age-related changes in ROS production and mitochondria m

161 c capacity (A(max)) was the primary cause of age-related changes in RUEs across temperate forest site

162 mm Hg [SE, 0.037 mm Hg]); associations with age-related changes in SBP between 6 and 17 years of age

163 marker of individual difficulties as well as age-related changes in sensation, perception, and compre

164 First, we find evidence consistent with age-related changes in SHM hot-spot targeting.

165 res dissecting the drivers and regulators of age-related changes in single-cell, tissue- and disease-

166 Moreover, age-related changes in skeletal muscle metabolism are af

167 Here we identified age-related changes in skin properties and CCBAs from st

168 ing in the Study of Physical Performance and Age-Related Changes in Sonomans (SPPARCS) to predict dea

169 lopment of cancer by accumulating mutations, age-related changes in stem cells likely contribute to a

170 n older subjects, critically contributing to age-related changes in SW oscillations.

171 ess, apoE2-TR mice showed similar or greater age-related changes in synaptic loss, neuroinflammation,

172 Although age-related changes in synaptic plasticity are an import

173 This review centers on age-related changes in T cells, which are dramatically a

174 We sought to characterize age-related changes in the AD profile.

175 ith a long postoperative life expectancy, as age-related changes in the anatomy of the anterior segme

176 The development and patterns of spontaneous age-related changes in the anterior cruciate ligament (A

177 peripheral choroid during accommodation, and age-related changes in the anterior sclera.

178 Five sets of studies examined age-related changes in the AONpP.

179 we present here a comprehensive study of the age-related changes in the Arabidopsis thaliana glycated

180 or connectivity in the ASD group and examine age-related changes in the ASD and control groups.

181 Depression may also accentuate age-related changes in the biophysical properties of cor

182 ute to HSC aging, little is known on whether age-related changes in the bone marrow niche regulate HS

183 Here, we provide an overview of age-related changes in the brain's chromatin structures,

184 that underlie interindividual variability in age-related changes in the brain.

185 T cell compartment and help to contextualize age-related changes in the CD8(+) T cell response to inf

186 degeneration in both fiber tracts, only the age-related changes in the cingulate bundle correlate wi

187 In this study we examined the age-related changes in the cortical and trabecular bone

188 studies in the macaque monkey have revealed age-related changes in the density of nicotinamide adeni

189 A final study found no age-related changes in the density of vasculature in the

190 The relationship between age-related changes in the expression of the astrocytic

191 There were also no age-related changes in the extent of the coverage of end

192 Evidence of age-related changes in the foraging efficiency of adult

193 to study developmental, disease-related, and age-related changes in the gene expression profile of sk

194 To investigate whether age-related changes in the gut microbiome may mediate ar

195 Age-related changes in the hematopoietic compartment are

196 Many age-related changes in the hematopoietic system, in part

197 re sensitive tasks to evaluate PA effects on age-related changes in the hippocampus, such as relation

198 Our study suggests that age-related changes in the HSP mechanisms are sufficient

199 However, the age-related changes in the immune function of human skin

200 A better understanding of the age-related changes in the immune system will allow us t

201 The authors examined age-related changes in the influence of this general fac

202 gnetic stimulation paradigm, we examined the age-related changes in the interhemispheric effects from

203 unger subjects, but there was no evidence of age-related changes in the magnitude or direction of pha

204 Age-related changes in the microbiota contribute to immu

205 iod in delayed matching to sample tasks, and age-related changes in the microcolumnar organization of

206 Age-related changes in the microstructure of these tract

207 Overall, age-related changes in the mouse show similar structural

208 mmon correlational methods are confounded by age-related changes in the neurovascular signaling.

209 Age-related changes in the niche have long been postulat

210 perception remains largely unaffected by the age-related changes in the optical media (yellowing of t

211 ings provide important new insights into the age-related changes in the peripheral blood pool of olde

212 Our studies demonstrated several deleterious age-related changes in the pool of Ag-specific CD8 T cel

213 Previously, we mapped age-related changes in the proteome and transcriptome (J

214 vestigated novel molecular markers and their age-related changes in the rat IVD.

215 To test the hypothesis that age-related changes in the response to simulated jet lag

216 To explore age-related changes in the SCN, we have performed in viv

217 These findings suggest that age-related changes in the structure and function of amy

218 The current study aimed to determine whether age-related changes in the superior longitudinal fascicu

219 icularly CMV, which has been associated with age-related changes in the T cell pool.

220 evalence of AMD was associated with distinct age-related changes in the T-cell compartment.

221 Age-related changes in the thymic cytokine milieu parall

222 lysis reveals that individuals with ASD show age-related changes in the trajectory of microglial and

223 ncreased near stop codons, revealing complex age-related changes in the translation process.

224 ells and antigen-presenting cells (APC), and age-related changes in the tumor microenvironment.

225 To define age-related changes in the visual field by comparing 'st

226 We believe that age-related changes in the ways salient stimuli are proc

227 proteins is necessary for understanding the age-related changes in their density throughout the maca

228 ammatory conditions is dependent on specific age-related changes in their molecular repertoire that e

229 posure to factors in young blood counteracts age-related changes in these central nervous system para

230 d is seen throughout the cochlea long before age-related changes in thresholds or hair cell counts.

231 mice reversed these changes, suggesting that age-related changes in TNFalpha expression are an import

232 We find that (1) age-related changes in tradeoffs partition the life cycl

233 so be considered as potential mechanisms for age-related changes in transcript levels.

234 Rapid reduction in threshold coupled with age-related changes in transduction protein levels and t

235 ts aged 8-19 years, we aimed to characterize age-related changes in trial-to-trial intraindividual va

236 We demonstrate statistically significant age-related changes in triglycerides (TG), diglycerides

237 Here, we examine age-related changes in urinary cortisol in a 20-y longit

238 ular senescence processes, may contribute to age-related changes in vascular function and health.

239 Age-related changes in visual exploration and memory hav

240 al cortex and their association with certain age-related changes in visual perception.

241 ctive measurement, with potential to measure age-related changes in vivo.

242 icity in the nucleus accumbens is central to age-related changes in voluntary running.

243 t and aged macaques to better understand how age-related changes in white matter connectivity at mult

244 racts except the brain stem, indicating that age-related changes in white matter microstructure diffe

245 adolescents and adults with ASD and whether age-related changes in white matter microstructure diffe

246 used in applications ranging from analyzing age-related changes in working memory to large-scale dat

247 However, longitudinal aging-related changes in brain functional modular archit

248 stic of aging human brain, and may influence aging-related changes in brain functions.

249 ued progress is being made on characterizing aging-related changes in cartilage.

250 us, this study reveals a novel mechanism for aging-related changes in CD8 T cells.

251 CR attenuated aging-related changes in cell type composition, gene exp

252 In sum, we have identified aging-related changes in cTfh that correlated with reduc

253 We examined age- and aging-related changes in functional architecture of the

254 ed single-cell RNA-sequencing to interrogate aging-related changes in the HFSCs.

255 ithout (kappa range, -0.046 to 0.173) taking age-related change into consideration.

256 transmodal network whose lifespan pattern of age-related change intrinsically supports this model of

257 Many of these central age-related changes involve altered mechanisms of inhibi

258 Each of the >3000 age-related changes is associated with a specific tissue

259 ) with control subjects without intermediate age-related changes (large drusen).

260 Such age-related changes might partly account for the increas

261 These results may be relevant to age-related changes observed in neurodegenerative diseas

262 Moreover, marked age-related changes occurred in many nonepithelial cell

263 Currently, we know very little about age-related changes occurring in the auditory sensory ce

264 Age-related change of macular and circumpapillary RNFL m

265 It describes the age-related change of performance in 17 time-series phen

266 Moreover, behavioral implications of age-related changes of cortical excitability remain elus

267 bly, independent of diet, RYGB also reversed age-related changes of membrane properties and occurrenc

268 study examines the effect of melatonin upon age-related changes of some key proteins relevant to the

269 circadian patterns of task performance, and age-related changes of task.

270 is a quantitative technique sensitive to the age-related changes of tendons.

271 o T cell unresponsiveness, caused by various age-related changes of the immune system.

272 rmore, this study provided major evidence of age-related changes on the volatile profile of diabetic

273 An underestimated aspect is that because of age-related changes, organ function such as erythropoiet

274 sizes in diffusion values between sexes and age-related changes showed findings parallel to ROI anal

275 linating white matter is more susceptible to age-related change than early-myelinating white matter,

276 recent developments in the understanding of age-related changes that affect key components of immuni

277 Immunosenescence is a series of age-related changes that affect the immune system and, w

278 ction anterior to the gland orifice; similar age-related changes that are detected in human subjects.

279 nimals, including mice and rats, demonstrate age-related changes that can contribute to osteoarthriti

280 cle during accommodation, and identify their age-related changes that could impact the optical change

281 acts displayed deviant early development and age-related changes that could underlie impaired brain f

282 to aging and raise the possibility that the age-related changes that occur in the nLOT might contrib

283 at recur during each seasonal cycle with the age-related changes that occur over years of growth.

284 After accounting for age-related change, the proportions decreased to 14.7%,

285 Brain diffusivity as a whole demonstrated age-related changes through four distinct periods of lif

286 Western blotting and proteomic methodology, age-related changes to a major protein, gammaS-crystalli

287 Widespread age-related changes to myelin were observed across the b

288 Age-related changes to the neurovascular unit (NVU), and

289 ency virus (HIV) infection induces premature age-related changes to the phenotype and function of mon

290 bidities, reduced physiological reserves and age-related changes to the spinal cord.

291 Understanding age-related changes to the UPR(ER) will provide new aven

292 end analysis before and after accounting for age-related change using the lower 95% confidence interv

293 None of these age-related changes were altered with exercise.

294 Some age-related changes were in an upward direction (GFAP an

295 Age-related changes were modeled using polynomial regres

296 However, these aging-related changes were reduced or absent in Nox2 kno

297 al tracts in ASD toddlers displayed abnormal age-related changes with greater fractional anisotropy a

298 of CRYalphaA(N101D)- vs. CRYalphaA(WT) mice: age-related changes with specific emphasis on protein in

299 Yet, the impact of amyloid-beta on age-related changes within the medial temporal lobe (MTL

300 To what extent and by what means age-related changes within the niche contribute to this