ライフサイエンスコーパス: agenesis

1 ovement is possible despite total cerebellar agenesis'.

2 ongitudinal vaginal septum and lower vaginal agenesis.

3 ntrols, especially in patients with complete agenesis.

4 assification 1.2) with associated left renal agenesis.

5 cortical abnormalities, and partial callosal agenesis.

6 isability and frequently displaying callosal agenesis.

7 xhibited partial or complete corpus callosum agenesis.

8 es from individuals with isolated pancreatic agenesis.

9 ectasias, capillary anomalies, and capillary agenesis.

10 ngle gene mutations associated with callosal agenesis.

11 nd Slit2 upregulation, resulting in callosal agenesis.

12 the most common cause of isolated pancreatic agenesis.

13 n factor 1a) in ten families with pancreatic agenesis.

14 subjects with normal tooth number and tooth agenesis.

15 y atresia, choledochal cysts and gallbladder agenesis.

16 nopus foregut resulted in liver and pancreas agenesis.

17 lopmental defects associated with pancreatic agenesis.

18 of both ligands in mice, resulted in kidney agenesis.

19 box transcription factor, both lead to cecal agenesis.

20 o be the most common cause of human pancreas agenesis.

21 ental disorders are associated with callosal agenesis.

22 a loss of foregut gene expression and organ agenesis.

23 and intestine development and caused spleen agenesis.

24 6 in 15/27 (56%) individuals with pancreatic agenesis.

25 tion, as their loss of function causes liver agenesis.

26 2-O-sulfotransferase (Hs2st) leads to kidney agenesis.

27 piratory system, such as lung hypoplasia and agenesis.

28 %) and 2 of 10 fetuses (20%) with unilateral agenesis.

29 d in Fgf10 knockout mice, which exhibit lung agenesis.

30 mesenchyme is inhibited, resulting in renal agenesis.

31 piratory tract abnormalities, including lung agenesis.

32 ated with autosomal dominant inherited tooth agenesis.

33 68%, while survival was 54% in patients with agenesis.

34 duals with both orofacial clefting and tooth agenesis.

35 tations are also causal for hereditary tooth agenesis.

36 m patients who presented with isolated renal agenesis.

37 y shaped, or ectopic, otoconia, or otoconial agenesis.

38 n permanent diabetes mellitus and cerebellar agenesis.

39 y an important role in the etiology of tooth agenesis.

40 scripts, a circumstance that can explain its agenesis.

41 or being the most common cause of pancreatic agenesis.

42 ted in midline facial cleft and frontal bone agenesis.

43 (+) tracheal mesoderm and tracheal cartilage agenesis.

44 ing in severe Shh loss of function and digit agenesis.

45 ng of the genetic etiology of familial tooth agenesis.

46 l coccygeal segments to complete lumbosacral agenesis.

47 in 2 families with suspected syndromic tooth agenesis.

48 intellectual disability, and corpus callosum agenesis.

49 tear production and LG volume reduction and agenesis.

50 with blind hemivagina and ipsilateral renal agenesis.

51 ified as likely pathogenic in isolated tooth agenesis.

52 ne gliosis, increased Slit2, and complete CC agenesis.

53 phenotype correlation between PAX9 and tooth agenesis.

54 function of the PAX9 protein underlies tooth agenesis.

55 ing a significant number of patients with LG agenesis.

56 tations are associated with human pancreatic agenesis.

57 have been identified in patients with tooth agenesis.

58 hinese families with nonsyndromic (NS) tooth agenesis.

59 re a rare cause of pancreatic and cerebellar agenesis.

60 4 additionally revealed homolateral vaginal agenesis.

61 obstructed hemivagina and ipsilateral renal agenesis.

62 of PAX9 that is responsible for human tooth agenesis (1) affects its functions.

63 tuses that had bilateral or unilateral renal agenesis (29 subjects) or severe congenital renal dyspla

64 ized by a high prevalence of corpus callosum agenesis (32/80; 40%), and mild to severe cerebellar hyp

65 ound in 7 of 19 fetuses with bilateral renal agenesis (37%) and 2 of 10 fetuses (20%) with unilateral

66 t PTF1A mutations in humans cause cerebellar agenesis, a birth defect of the human cerebellum.

67 understanding how this mutation caused renal agenesis, a failure of fetal kidney development.

68 l anomalies including callosal hypoplasia or agenesis, abnormal basal ganglia and cerebellar hypoplas

69 ain malformations, including corpus callosum agenesis (ACC) and microcephaly.

70 tions as the most common cause of pancreatic agenesis, accounting for 15 of 27 (56%) patients with in

71 R) syndrome and Six1(-/-) mice exhibit renal agenesis, although the ureter is present.

72 Eighty-two individuals with tooth agenesis and 328 individuals with no birth defect were r

73 5Cys), resulting in a syndrome of pancreatic agenesis and abnormal forebrain development in three ind

74 ed 184 patients in our repository with renal agenesis and analyzed their exome/genome data.

75 It has been proposed that tooth agenesis and cancer development share common molecular p

76 the developing ureteric bud developed kidney agenesis and collecting duct cells had severe cytoskelet

77 genetic modifier contributing to pancreatic agenesis and demonstrates the usefulness of using patien

78 Frem1(eyes2) mice have eye defects, renal agenesis and develop retrosternal diaphragmatic hernias

79 ing Wnt2/2b expression exhibit complete lung agenesis and do not express Nkx2.1, the earliest marker

80 These mutants display ventral pancreas agenesis and ectopic masses of hepatocytes.

81 b) in the ventral endoderm leads to tracheal agenesis and ectopic primary bronchi.

82 ne the most common cause of human pancreatic agenesis and establish a key role for the transcription

83 ects in lung maturation and exhibit callosal agenesis and forebrain defects that are similar to, but

84 ATA6 haploinsufficiency can cause pancreatic agenesis and heart defects.

85 cribe a novel genetic syndrome of pancreatic agenesis and holoprosencephaly.

86 Renal agenesis and hypodysplasia (RHD) are major causes of ped

87 this reduction is sufficient to explain the agenesis and hypoplasia observed in both mutants.

88 novel LRP6 mutations in patients with tooth agenesis and investigate the significance of Lrp6 during

89 roadens the mutation spectrum of human tooth agenesis and is the first to identify a LRP6 mutation in

90 and environmental) determining both callosal agenesis and its autistic features, and what are the pro

91 individuals with isolated central pair (CP) agenesis and normal body laterality, from two unrelated

92 ctural abnormalities, in particular callosal agenesis and pontine hypoplasia, delayed myelination and

93 fects range from mild hypoplasia to complete agenesis and Probst's bundle formation.

94 icant associations between patterns of tooth agenesis and rugae number, in addition to shape of prima

95 ical and molecular association between tooth agenesis and self-reported family history of cancer.

96 h increases the spectrum of congenital tooth agenesis and suggests attenuated Wnt signaling in endoth

97 etic contributions to kidney development and agenesis and the factors influencing susceptibility to r

98 Agenesis and tooth displacements were the most common de

99 ullerian ducts characterized by uterovaginal agenesis and underdeveloped female genital organs.

100 otal of 218 patients (14%) had diaphragmatic agenesis and underwent repair.

101 fects, including epidermis and prostate buds agenesis and urothelial abnormalities.

102 out mice leads to high bone mass, lymph node agenesis, and altered lymphocyte differentiation.

103 atures of syndromes associated with callosal agenesis, and provides a genetic and developmental frame

104 incidence of unilateral and bilateral renal agenesis, and smaller kidneys with fewer nephrons.

105 tal syndromes characterized by basal ganglia agenesis are not known to date.

106 ructed Seminal Vesicle and Ipsilateral Renal Agenesis) as an acronym for Zinner syndrome analogous to

107 ion in the entire epiblast leads to pancreas agenesis associated with abnormal gut regionalization.

108 Tracheal agenesis/atresia (TA) is a rare but fatal congenital dis

109 Bilateral renal agenesis (BRA) represents the most severe and fatal form

110 ctive studies are needed to confirm if tooth agenesis can be used as a risk marker for cancer.

111 ng periodontal disease, dental caries, tooth agenesis, cancers of the head and neck, orofacial pain,

112 ltisystem disorder characterized by callosal agenesis, cataracts, cardiomyopathy, combined immunodefi

113 ion to the five principal features (callosal agenesis, cataracts, hypopigmentation, cardiomyopathy, a

114 Can kindreds with tooth agenesis caused by MSX1 or PAX9 mutations be distinguish

115 y, we investigated whether the 5 known tooth-agenesis-causing MSX1 missense mutations disrupt this Pa

116 Bmp4 promoter construct, and that most tooth-agenesis-causing PAX9 mutations impair DNA binding and B

117 leting both Fgf8 and Fgf20 results in kidney agenesis, defects in NPC proliferation, and cell death.

118 st-derived dental mesenchyme and cause tooth agenesis disorder when mutated in mouse and/or human.

119 ptors (NgR123-null mice) display complete CC agenesis due to axon misdirection evidenced by ectopic a

120 ta6 in the pancreas caused severe pancreatic agenesis due to disruption of pancreatic progenitor cell

121 g one copy of Spry1, which rescued the renal agenesis due to loss of Fgf9 and Fgf20.

122 ng bilateral cleft lip and palate and tongue agenesis, following the loss of the primary cilia in the

123 all available data on worldwide third molar agenesis frequencies, with a particular emphasis on expl

124 Finally, we found large differences among agenesis frequency depending on geographic region.

125 nd toward improved survival in patients with agenesis from 47% in the first 2 years to 59% in the las

126 autistic behaviour associated with callosal agenesis from autism more generally.

127 When patients with diaphragmatic agenesis from the first 2 years were compared with simil

128 in the control group and curved in the tooth agenesis group (p = 0.012 and p = 0.004, respectively).

129 n number of missing tooth units in the tooth agenesis group was 2.1.

130 04) was significantly increased in the tooth agenesis group.

131 ction (p = 0.04 for both rugae) in the tooth agenesis group.

132 control and 13.56 (SD, 1.54) years in tooth agenesis groups (p = 0.576).

133 Individuals with tooth agenesis had an increased risk of having a family histor

134 The survivors with diaphragmatic agenesis had prolonged hospital stays compared with pati

135 ranslocation associated with bilateral renal agenesis has implicated the gene encoding the nuclear st

136 udy shows that modern individuals with tooth agenesis have indeed smaller facial configurations.

137 ith orofacial clefting with or without tooth agenesis have MSX1 coding mutations by screening 33 indi

138 tions in PDX1 and PTF1A can cause pancreatic agenesis, however, most instances of this disorder are o

139 nal transduction components display cochlear agenesis; however, a detailed understanding of the trans

140 either factor are associated with pancreatic agenesis; however, homozygous deletion of both Gata4 and

141 eous stock-derived model of unilateral renal agenesis (HSRA) rat, which demonstrates 50%-75% spontane

142 included duplex and multiplex kidneys, renal agenesis, hydronephrosis and cystic kidney disease.

143 ompanied by hypogonadism and seminal vesicle agenesis/hypodysplasia.

144 enital anomalies of seminal vesicles include agenesis, hypoplasia, duplication, fusion, and cyst.

145 mperature indicators were observed for renal agenesis/hypoplasia (positive) and anophthalmia/micropht

146 een AXIN2, FGF3, FGF10, and FGFR2 with tooth agenesis [i.e., individuals who carried the polymorphic

147 ariants in candidate disease genes for tooth agenesis in 10 multiplex Turkish families.

148 gene were identified segregating with tooth agenesis in 2 families, suggesting oligogenic inheritanc

149 hrogenesis, the demonstrated rescue of renal agenesis in a model of a human genetic disease raises th

150 agenesis was 36% more likely than mandibular agenesis in both sexes.

151 Here, we show that lung agenesis in Fgf10 knockout mice can be rescued by ubiqui

152 This prevented renal agenesis in Fras1(bl/bl) mice, permitting kidney develop

153 y the ureteric bud, leads to bilateral renal agenesis in humans with Fraser syndrome and blebbed (Fra

154 y a few genes have been linked to pancreatic agenesis in humans, with mutations in pancreatic and duo

155 factors PAX9 and MSX1 cause selective tooth agenesis in humans.

156 molecular basis associated to basal ganglia agenesis in humans.

157 n mice, and GATA6 mutations cause pancreatic agenesis in humans.

158 cent brainstem or die, leading to cerebellar agenesis in Ptf1a mutants.

159 CAKUT that are markedly different than renal agenesis in Ret-null or RetY1062F mutant mice.

160 We analyzed patterns of partial tooth agenesis in seven kindreds with defined MSX1 mutations a

161 n contrast to complete deafness and cochlear agenesis in the C3HeB/FeJ strain, F2 Eya1(bor/bor) mutan

162 of orofacial clefting with or without tooth agenesis in this study population.

163 ertips and toes, and uni- or bilateral renal agenesis in three individuals.

164 Tooth agenesis is a common craniofacial abnormality in humans

165 Pancreatic agenesis is a human disorder caused by defects in pancre

166 Internal carotid artery agenesis is a rare anomaly that can be clinically asympt

167 the 1994 paper was to show that 'cerebellar agenesis is always associated with profound motor defici

168 Since tooth agenesis is commonly found in individuals with cleft lip

169 Tooth agenesis is complex, and variations in about a dozen gen

170 tering a patient with lacrimal dysgenesis or agenesis is not an uncommon occurrence in an oculoplasti

171 Tooth agenesis is one of the most common developmental anomali

172 Tooth agenesis is one of the most common developmental anomali

173 nce of missing permanent teeth, namely tooth agenesis, is common.

174 Oligodontia, a severe form of tooth agenesis, is genetically and phenotypically a heterogene

175 nactivated in human patients with cerebellar agenesis, is required to segregate the cerebellum from m

176 s autism spectrum disorders, corpus callosum agenesis, Joubert syndrome, Kallmann syndrome, and horiz

177 fralpha1(TM/TM) mice display bilateral renal agenesis, lack enteric neurons in the intestines, and ha

178 Despite molar agenesis, Lhx6/7-deficient animals have normal incisors

179 ignificant progress in the genetics of tooth agenesis, many gaps in knowledge exist in refining the g

180 specific CAKUT phenotype of unilateral renal agenesis may also be mutated in humans with isolated CAK

181 nitive impairments in subjects with callosal agenesis may overlap with the profile of autism spectrum

182 tood, but congenital venous valve aplasia or agenesis may play a role in some cases.

183 ospital stays compared with patients without agenesis (median, 68 vs. 30 days).

184 malformations, which include isolated tooth agenesis, microdontia, short tooth roots, taurodontism,

185 2 (-/-) single mutants, including skull bone agenesis, midline facial cleft, and syngnathia.

186 ice results in cardiac malformation, adrenal agenesis, neural tube, placental defects and partially p

187 otient and autism symptomatology in callosal agenesis, nor evidence that the presence of any residual

188 branching ureteric bud (UB), and that renal agenesis occurs in homozygous Fras1 null mutant blebbed

189 t women are 14% more likely than men to have agenesis of >/=1 third molars and that maxillary agenesi

190 Furthermore, we found that having agenesis of 1 or 2 molars was most common, while agenesi

191 esis of 1 or 2 molars was most common, while agenesis of 3 or 4 molars was least common.

192 s Odd 1(-/-) mutant embryos exhibit complete agenesis of adrenal glands, metanephric kidneys, gonads,

193 smorphism, brain malformation (microcephaly, agenesis of corpus callosum, and simplified gyration), a

194 mations including hippocampus hypoplasia and agenesis of corpus callosum, as well as neuromuscular an

195 disorder, that could be named ACOG syndrome (agenesis of corpus callosum, axon pathfinding, cardiac,

196 ation family with affected males showing ID, agenesis of corpus callosum, cerebellar hypoplasia, micr

197 everal structural brain anomalies, including agenesis of corpus callosum.

198 oss of Lmx1a and Ngn2 expression, as well as agenesis of DA neurons in the midbrain floor plate.

199 clear receptor superfamily, causes selective agenesis of dopaminergic neurons in midbrain.

200 in defects, whereas Nfic-deficient mice have agenesis of molar tooth roots and severe incisor defects

201 The phenotype is characterized by severe agenesis of multiple laminated cerebral structures affec

202 a unique brain malformation characterized by agenesis of putamina and globi pallidi, dysgenesis of th

203 It is typically attributed to agenesis of the abducens and facial cranial nerves.

204 ants had shortened limbs and almost complete agenesis of the autopod because of reduced cell prolifer

205 this defect could arise from instability or agenesis of the ciliary central microtubules due to loss

206 anual motor coordination in individuals with agenesis of the corpus callosum (ACC) was studied using

207 and five sporadic individuals with isolated agenesis of the corpus callosum (ACC) without intellectu

208 the brain, including microcephaly (MIC) and agenesis of the corpus callosum (ACC).

209 and speech execution in 25 participants with agenesis of the corpus callosum (AgCC) and 21 matched ne

210 t for hemispheric dominance in patients with agenesis of the corpus callosum (AgCC) and found reduced

211 ate fMRI in eight adult humans with complete agenesis of the corpus callosum (AgCC) and normal intell

212 specifically, we investigated the effect of agenesis of the corpus callosum (AgCC), one of the most

213 Agenesis of the corpus callosum (CC) is a rare birth def

214 motor and sensory neuropathy associated with agenesis of the corpus callosum (HMSN/ACC), a neurodevel

215 ene of peripheral neuropathy with or without agenesis of the corpus callosum (SLC12A6).

216 h is a model with polycystic kidney disease, agenesis of the corpus callosum and hydrocephalus.

217 previously that Nfia-deficient mice exhibit agenesis of the corpus callosum and other forebrain defe

218 ound sensorineural hearing loss, and partial agenesis of the corpus callosum are hallmarks of the cli

219 Agenesis of the corpus callosum is a common brain malfor

220 Agenesis of the corpus callosum is a congenital conditio

221 that microglia deficiency may contribute to agenesis of the corpus callosum via reduction in CUX1(+)

222 had anomalies on brain imaging ranging from agenesis of the corpus callosum with hydrocephalus to cy

223 ficiency: Nova2-/- but not Nova1-/- mice had agenesis of the corpus callosum, and axonal outgrowth de

224 , spastic quadriplegia, developmental delay, agenesis of the corpus callosum, and enlargement of the

225 cluding enlarged ventricles, thinned cortex, agenesis of the corpus callosum, and significantly reduc

226 ventricles, reduced cerebral cortex, partial agenesis of the corpus callosum, and thinning of layers

227 ze of the hippocampal dentate gyrus, partial agenesis of the corpus callosum, and ventriculomegaly.

228 res present in multiple individuals included agenesis of the corpus callosum, ano-rectal malformation

229 Donnai-Barrow syndrome is associated with agenesis of the corpus callosum, congenital diaphragmati

230 titutional DNA-mismatch repair deficiency is agenesis of the corpus callosum, the cause of which has

231 ntonasal dysplasia, interhemispheric lipoma, agenesis of the corpus callosum, tibial hemimelia, preax

232 g with dyskinetic cerebral palsy and partial agenesis of the corpus callosum, while histochemical and

233 aracterized by severe mental retardation and agenesis of the corpus callosum.

234 Those children with large defects or agenesis of the diaphragm have the highest mortality and

235 nital diaphragmatic hernia (CDH), those with agenesis of the diaphragm.

236 beta-catenin in Isl1-expressing cells caused agenesis of the hindlimb skeleton and absence of the low

237 Agenesis of the lateral incisor on the non-cleft side wa

238 Hypoplasia and agenesis of the liver lobe is a rare abnormality.

239 chondrial function, embryonic lethality, and agenesis of the liver.

240 of both Osr1 and Osr2 (Osr1/Osr2) results in agenesis of the lungs, trachea and esophagus.

241 Agenesis of the mutant germ cells was accompanied by inc

242 (Dnmt1) in pancreatic progenitors results in agenesis of the pancreas due to apoptosis of progenitor

243 left-dominant liver and short pancreas with agenesis of the pancreatic tail and lateral part of the

244 vival and proliferation, and consequently in agenesis of the perineum and severe hypoplasia of the ge

245 tato-olivary dysplasia and severe hypoplasia/agenesis of the pyramidal tracts.

246 of Esrrg on both alleles (Esrrg(-/-)) showed agenesis of the renal papilla but normal development of

247 In addition, lack of both ligands causes agenesis of the swim bladder, the structural homolog of

248 Obstructed hemi-vagina and ipsilateral renal agenesis (OHVIRA) syndrome.

249 Imbalance of these cues results in CC agenesis or dysgenesis.

250 ell as isolated Klippel-Feil syndrome, renal agenesis or esophageal atresia.

251 Isolated or nonsyndromic tooth agenesis or hypodontia is the most common human malforma

252 e most severe renal anomaly, bilateral renal agenesis or hypoplasia (RA/H), has limited the ability t

253 Among them, renal agenesis or hypoplasia, decreased innervation of the gut

254 /or intellectual disability, corpus callosum agenesis or hypoplasia, flexion contractures, brachydact

255 le axon pathfinding defects (corpus callosum agenesis or hypoplasia, mirror movements, Duane anomaly)

256 nephronectin gene frequently display kidney agenesis or hypoplasia, which can be traced to a delay i

257 diated AKT/MAPK activation resulted in renal agenesis or kidney rudiments, whereas mutation of this r

258 PTF1A mutations in patients with pancreatic agenesis or neonatal diabetes but no cerebellar phenotyp

259 potential avenues for therapies for callosal agenesis or related neurodevelopmental disorders.

260 Complete loss of function in mice results in agenesis or severe disruption of periocular mesenchyme s

261 ion of the mouse Sall1 gene results in renal agenesis or severe dysgenesis.

262 that stillborn fetuses with congenital renal agenesis or severe dysplasia would possess mutations in

263 lleles and one Etv5 allele show either renal agenesis or severe hypodysplasia, whereas kidney develop

264 e often in subjects with both CL/P and tooth agenesis (p = 0.0008), while the *6C-T variant was found

265 8) presented higher risk for having premolar agenesis (p = 0.02; OR = 1.8; 95% C.I., 1.1-3.0)].

266 y, hospital length of stay, and morbidity in agenesis patients remain significant.

267 ene in these patient cells and 32 additional agenesis patients revealed a higher minor allele frequen

268 ed quite well with the severity of the tooth agenesis pattern seen in vivo.

269 t the mutations co-segregated with the tooth agenesis phenotype (with exception of families in which

270 e GAG chain is key as evidenced by the renal agenesis phenotype in mice deficient in the HS biosynthe

271 ng view that the defect underlying the renal agenesis phenotype is due to a primary role for 2-O sulf

272 of Fgf9 and Fgf20, rescuing bilateral renal agenesis premature NPC differentiation, NPC proliferatio

273 nusual and interesting account of cerebellar agenesis published in Brain in 1994 by Glickstein, in wh

274 ve been made, the genetic etiology of dental agenesis remains largely unknown.

275 Further, we propose that cerebellar agenesis represents a new, dorsal-to-ventral, cell fate

276 Agenesis requires an extensive work-up as a number of as

277 Previous evidence from tooth agenesis studies suggested IRF6 and TGFA interact.

278 ology, we found that 8/26 (about a third) of agenesis subjects presented with autism.

279 etween subjects with normal tooth number and agenesis suggests potential commonality in signal pathwa

280 quently been reported as etiologic for tooth agenesis (TA).

281 that a loss of Eya 1 function leads to renal agenesis that is a likely result of failure of metanephr

282 PAX9 are associated with non-syndromic tooth agenesis that preferentially affects posterior dentition

283 identified in only one fetus with unilateral agenesis; this subject also had two RET mutations.

284 compared a group of 26 adults with callosal agenesis to a group of 28 adults with a diagnosis of aut

285 etes manifestations, ranging from pancreatic agenesis to adult-onset diabetes with subclinical or no

286 ng from severe manifestations, such as renal agenesis, to potentially milder conditions, such as vesi

287 esis of >/=1 third molars and that maxillary agenesis was 36% more likely than mandibular agenesis in

288 Tooth agenesis was assessed in permanent teeth and was defined

289 A significant reduction of LG size or agenesis was associated with mutations affecting protein

290 In conclusion, tooth agenesis was associated with positive self-reported fami

291 The worldwide rate of agenesis was found to be 22.63% (95% confidence interval

292 was hyperactive in these foreguts when lung agenesis was observed.

293 Pancreatic agenesis was present in 21 case subjects (six new); two

294 years of the study, 36% of the patients with agenesis were discharged on tube feedings and 22% on oxy

295 childhood behaviour indicated children with agenesis were less likely to meet diagnostic criteria fo

296 ciency in mice results in metanephric kidney agenesis, whereas knockdown or mutation studies in zebra

297 Caudal regression syndrome (sacral agenesis), which impairs development of the caudal regio

298 r characterized by pancreatic and cerebellar agenesis, which indicates that the association of P48 an

299 WNT pathways genes in the etiology of tooth agenesis while revealing new candidate genes.

300 USG and MRI showed left renal agenesis with compensatory hypertrophy of the right kidn