ライフサイエンスコーパス: aggregate

1 ntimicrobial treatment of plague reported in aggregate.

2 n of proteasome and autophagy proteins to GA aggregates.

3 ol system, leading to formation of cytotoxic aggregates.

4 accumulation of alpha-synuclein (alpha-Syn) aggregates.

5 including protein quality control of nuclear aggregates.

6 ission that is not observed for limited CQDs aggregates.

7 er of proteins, and the formation of protein aggregates.

8 asmic reticulum and the clearance of protein aggregates.

9 anized and very well structured with smaller aggregates.

10 is a suitable PET tracer for imaging of mHTT aggregates.

11 resulting in such a critical mass of protein aggregates.

12 e denitrification in anoxic zones in organic aggregates.

13 P52, and TAX1BP1 in clearance of proteotoxic aggregates.

14 implicated in moDC maturation induced by IFX aggregates.

15 of Huntington's disease-linked polyQ protein aggregates.

16 such as dysfunctional organelles and protein aggregates.

17 formation, modification, and dissolution of aggregates.

18 ng in the formation of structurally distinct aggregates.

19 he aim to promote the emergence of non-toxic aggregates.

20 of guanidine hydrochloride (GdnHCl) on Sup35 aggregates.

21 machinery to recognize a broad range of Tau aggregates.

22 reorganize to form filamentous Ku-containing aggregates.

23 organelles, pathogens, and unwanted protein aggregates.

24 olk and allowed them to develop as spherical aggregates.

25 ormation and compartmentalization of protein aggregates.

26 Wtf4(poison) protein forms dispersed, toxic aggregates.

27 he amplification of ring currents in stacked aggregates.

28 identified in 5%-12% of beta cell containing aggregates, 3-76 months posttransplant.

29 9,675 index encounters were analyzed with an aggregate 30-day revisit rate of 10.8%.

30 niques were employed to characterize a novel aggregated 3D lung adenocarcinoma model, developed by th

31 Annual and aggregate 5-year incidences were determined for all cata

32 HD mouse striatum reduce mutant HTT protein aggregates, a biomarker of HD pathogenesis and severity.

33 a variety of soluble oligomers and insoluble aggregates, a process that is associated with an increas

34 modestly promote the formation of alpha-syn aggregates, accelerate the severe and progressive degene

35 e analysed at the country-specific level and aggregated according to country income group and the pro

36 In agreement with these data, protein aggregate accumulation and microglia activation were obs

37 Ube2v1 knockdown decreased aggregate accumulation caused by CryAB(R120G) expression

38 fferences from the benchmark (residuals) are aggregated across multiple timescales using Principal Co

39 stem from unique strains of alpha-synuclein aggregates, akin to what occurs in prion diseases.

40 Analyses aggregating all 6 wk of posttax time points showed stati

41 Aggregated alpha-syn destabilizes the G4Q leading to unf

42 ntra-neuronal Lewy body (LB) inclusions with aggregated alpha-synuclein (alpha-Syn) as the major comp

43 cation in neuronal cells can induce seeds of aggregated alpha-synuclein or DISC1 that may be able to

44 These aggregates also share morphological and structural ident

45 Aggregate analysis shows that bimetallic and dilute allo

46 go conformational changes that allow them to aggregate and assemble into insoluble, fibrillar structu

47 Mechanistically, mitochondria aggregate and depolarize after stress because of loss of

48 We use aggregated and anonymized information based on internati

49 th its Hsc70 partner to recognize and manage aggregated and misfolded proteins.

50 VID-19 also present with neutrophil-platelet aggregates and a distinct neutrophil and platelet activa

51 ecapitulated the effects of FAM46C, inducing aggregates and apoptosis.

52 d intestinal mucins, resulting in very large aggregates and depletion of macromolecular mucin and occ

53 laments that organized into complex filament aggregates and fibrillar sheets.

54 several cells, are abundant both in cultured aggregates and in MPM surgical specimens.

55 hich sequesters preformed fibrils into large aggregates and is believed to have a cytoprotective func

56 ages on the surface of defined multicellular aggregates and monitor sorting outcomes by live imaging.

57 higher net conductivity versus that of spore aggregates and non-viable C. difficile forms, which caus

58 Sphere-like aggregates and spindle-shaped structures were, respectiv

59 lysis of the explanted heart revealed desmin aggregates and the absence of desmin filaments at interc

60 ng calcium hydroxide paste, mineral trioxide aggregate, and glass ionomer resin, are used with mixed

61 tes, (iii) aggregates per cell, (iv) area of aggregates, and (v) localization of aggregates (cytosol,

62 nd rapid appearance of high molecular weight aggregates, and an age-dependent transfer of intracellul

63 In addition, alpha-synuclein aggregates appeared in infected cell populations connect

64 Misfolded tau aggregates are able to spread the pathology from cell-to

65 cture-property relationships established for aggregates are expected to contribute to new materials a

66 Amyloid aggregates are found in many neurodegenerative diseases,

67 Furthermore, size and shape of aggregates are heterogeneous in depth, where a small num

68 riability and ELISA specificity for inactive aggregates are key factors to consider when designing an

69 critical to protein quality control, but how aggregates are selectively targeted for degradation is u

70 au oligomers, small and soluble prefibrillar aggregates, are highly toxic due to their strong ability

71 Here, we show that mutant huntingtin (mHtt) aggregates associated with Huntington disease transfer a

72 us, the predictability of activity variation aggregated at a daily scale, and the clear signal that b

73 he U.S., demographic data are only available aggregated at county or coarser scales, so disease model

74 ication, and quarter (date of case reporting aggregated at three-month intervals) explained 93.6% of

75 ies to undergo phase transition to insoluble aggregates at lower temperatures.

76 We demonstrate that alpha-syn aggregates attenuate NK cell cytotoxicity in a dose-depe

77 e magnetic beads, cancer cells and bead-cell aggregates based on their various impedance and frequenc

78 for early detection of AD biomarkers such as aggregated beta-amyloid and tau proteins.

79 tural activity studies; lead optimization of aggregate-binding affinity, unbound fractions in brain,

80 y make it easier to communicate, access, and aggregate biodiversity information, there is a need for

81 uency, <=5%) measured by an exome array were aggregated by genes and evaluated by a gene-environment

82 sting approaches describe the fusion of cell aggregates by analogy with the coalescence of liquid dro

83 We generated aggregates by submitting infliximab (IFX), an immunogeni

84 cteristics of the different strains that tau aggregates can adopt.

85 usion, protein denaturation and formation of aggregates can be controlled by manipulating feed moistu

86 f a covalent chemical process on noncovalent aggregates can be mediated, which holds great potential

87 eded in fibrous gels, pairs of cells or cell aggregates can induce bands of deformed gel, extending t

88 robing the chromatin landscape of single and aggregated cells.

89 plain up to 50% of the variation in district-aggregated changes in wealth over time, with daytime ima

90 e droplet stage), macroscopic interconnected aggregate clusters form, grow, fuse, and evolve via inte

91 ool due to their flexibility in modeling the aggregate CNV effects, their ability to capture effects

92 f future climatic changes rely on seasonally aggregated, coarse-resolution data.

93 Oxygenic photogranules (OPGs), spherical aggregates comprised of phototrophic and nonphototrophic

94 ibrils are highly ordered nanoscopic protein aggregates comprising a cross-beta amyloid core and are

95 ivotal role of the GPI-anchor in driving the aggregate conformation and disease phenotype.

96 eous in depth, where a small number of large aggregates control the concentration versus depth profil

97 The aggregate costs of sepsis care for Medicare beneficiarie

98 Aggregate costs were higher for TAVR than SAVR and were

99 area of aggregates, and (v) localization of aggregates (cytosol, perinuclear, or nuclear).

100 We further aggregated data from 1498 patients with DCM sequenced in

101 of more than 500 000 participants, which has aggregated data from questionnaires, physical measures,

102 data for 110 (~80%) species in the group and aggregated data layers for body shape, habitat occupancy

103 nvironmental parameters and more than 50,000 aggregated data points of measured groundwater arsenic c

104 The aggregate demographic details for study participants wer

105 ity rate (WSAR), but decreased percentage of aggregates destruction (PAD) than CC treatment.

106 t any time to sustain the drag forces on the aggregate determines whether it remains intact or sheds

107 dementia (FTD) and lead to the production of aggregating dipeptide repeat proteins (DPRs) via repeat

108 facilitate its action to clear intranuclear, aggregated disease proteins like HTT.

109 of model phthalocyanine compounds and their aggregates display clear magnetic field dependences up t

110 around room temperature in solution when the aggregates dissolve or when the compound is well dispers

111 hway and inspire a suggestion as to why this aggregate does not grow to larger sizes.

112 Aggregated drug resistance data reported to WHO from eit

113 esults, which points at a direct role of the aggregates during polymerization, which disrupts the ide

114 r time in 14/20 patients (with a significant aggregate effect across patients, Fisher's method: P < 0

115 ttle attention has been given to whether the aggregated effect of energy transitions poses a substant

116 Results The aggregated energy consumption imaging 40 276 patients am

117 se, and improve interpretation and power, by aggregating expression data to the pathway level.

118 u isoforms as well as Sarkosyl-resistant Tau aggregates extracted from cell cultures and human AD bra

119 Denoted as foliate lymphoid aggregates (FLAgs), these structures show incomplete T/B

120 llees, and trends were reported over time in aggregate followed by modality (CT, MRI, nuclear imaging

121 ore acute cytotoxicity than the soluble, non-aggregated form.

122 at lower temperatures in THF solution, where aggregates form upon cooling, the TADF mechanism takes o

123 ed platelet activation and platelet-monocyte aggregate formation are observed in severe COVID-19 pati

124 Leukocyte recruitment and heterocellular aggregate formation drive the inflammatory vaso-occlusiv

125 Overexpressing Ube2v1 promoted aggregate formation in CryAB(WT) and CryAB(R120G)-expres

126 intracellular mechanisms leading to product aggregate formation remain unknown.

127 ion of Ube2v1 decreases CryAB(R120G)-induced aggregate formation through enhanced ubiquitin proteasom

128 equence almost invariably avoids off-pathway aggregate formation, by folding reliably into its native

129 Ube2v1 plays an important role in protein aggregate formation, partially by enhancing K63 ubiquiti

130 To minimize aggregate formation, we heterologously expressed BrPGIP3

131 ation and the proteasome may together impede aggregate formation.

132 unusual properties, such as specificity for aggregated forms of the peptide, the ability to distingu

133 The range of aggregate fractal dimensions found (2.22-2.42) implies a

134 erview, a list of radiology AI companies was aggregated from the Radiological Society of North Americ

135 The prion model predicts the release of aggregates from a first-order cell and subsequent uptake

136 we have developed a new platform-TeSS-which aggregates geographically distributed information and pr

137 al cornerstone of dendroecology, Cook's 1987 aggregate growth model, and the great potential to use t

138 verse media, the ill-defined nature of these aggregates has made it difficult to elucidate the struct

139 fibroblasts from patients with CMT1A, PMP22 aggregates have been observed.

140 Among these factors, BP aggregates have been suggested to promote immunogenicity

141 ber of metrics: (i) total number of cellular aggregates, (ii) percentage of cells with aggregates, (i

142 ar aggregates, (ii) percentage of cells with aggregates, (iii) aggregates per cell, (iv) area of aggr

143 When not feeding on human blood bed bugs aggregate in refuges close to human hosts.

144 structural and functional features have been aggregated in MISCAST from multiple databases, and displ

145 ), as a bona fide ERAD substrate that became aggregated in the endoplasmic reticulum following ERAD d

146 ein TDP-43 forms intranuclear or cytoplasmic aggregates in age-related neurodegenerative diseases.

147 wing that LSD1 localizes to pathological tau aggregates in Alzheimer's disease cases, and that it is

148 n drive formation and disassembly of protein aggregates in both conformational states.

149 ction of pathologic tau led to increased tau aggregates in mice in which p.Asp395Gly VCP mice was kno

150 Line 66 mice express intracellular tau aggregates in multiple brain regions and exhibit sensori

151 vation accelerates the spread of tau protein aggregates in neural networks.

152 articular, numerous proteins that form toxic aggregates in neurodegenerative diseases, such as amyotr

153 k of LD is the presence of abnormal glycogen aggregates in neurons and other tissues.

154 trains that propagate neuronal and glial tau aggregates in nontransgenic (nonTg) mouse brain.

155 ntrolling the self-assembled nanoscale ionic aggregates in single-ion conducting polymers is a crucia

156 The fluorescent secretory protein forms aggregates in the ER lumen and can be rapidly disaggrega

157 Here, we show that Can GPC aggregates in the ER of infected cells, forming incorrec

158 east 12 of the analyzed grains were parts of aggregates in the interstellar medium: The large differe

159 otor neuron cells, often forming cytoplasmic aggregates in the process.

160 these pathways localize to, or form distinct aggregates in the vicinity of, germ granules.

161 lineages sort to the interior of ectodermal aggregates, including single ectodermal cells.

162 he aggregate residential homogeneity and the aggregate income homogeneity.

163 o 329) and cumulative RFI volatility with an aggregate increase in macular RFI by >=10 points from th

164 Aggregates increase the risk of immune responses in pati

165 lity and (2) cumulative RFI instability with aggregate increased RFI were associated with intolerance

166 A data table of aggregate information on a per cell basis, as well as a

167 Notably, a meta-analytical approach that aggregated information across teams yielded a significan

168 on in rabbits, sunitinib microparticles self-aggregate into a depot that remains localized and mainta

169 Amyloidogenic peptides and proteins aggregate into fibrillary structures that are usually de

170 to cirrhosis, to test whether such variants, aggregated into a polygenic score, enable genomic risk s

171 that proteasomes could fragment filamentous aggregates into smaller entities, restricting aggregate

172 Our approach is to simplify the network by aggregating into groups the nodes that do not contribute

173 Selective autophagic elimination of aggregates is critical to protein quality control, but h

174 The accumulation of amyloid Tau aggregates is implicated in Alzheimer's disease (AD) and

175 Incorporation of individual and aggregate level data on social and environmental determi

176 s mainly investigated sitting behavior on an aggregate level, for example, by analyzing total sitting

177 ndom-effects meta-regression analysis of the aggregate-level data showed a trend towards greater shar

178 and highlights the interplay between nuclear aggregate-like assemblies and PML-mediated protein quali

179 e cytoplasmic cargo (e.g., proteins, protein aggregates, lipid droplets or organelles) to the vacuole

180 gh cleavage by human neutrophil elastase and aggregate lipopolysaccharide (LPS) and the Gram-negative

181 Thus, using realistic assumptions when de-aggregating locations based on available data can have a

182 veals that wtf parasites can exploit protein aggregate management pathways to selectively destroy spo

183 ons we demonstrate the redispersion of large aggregated metal oxide particles into metallic nanoparti

184 so performed, however, none outperformed the aggregate microarray network despite having good predict

185 nd phylogenetic information may help predict aggregate microbial community functions like BGE and the

186 s to unprecedented percolated gyroidal ionic aggregate morphologies that provide a continuous pathway

187 These order-to-order transitions in ionic aggregate morphologies were also confirmed by oscillator

188 ractal dimension (D) in mechanical stability aggregates (MSAs), and increased MWD and geometric mean

189 smallest possible noncovalent H-type BODIPY aggregate, namely, an H-dimer.

190 ers with the PNPs induce dispersed or weakly aggregated nanocomposite morphologies, depending on the

191 eptible to potential bias resulting from the aggregate nature of the ecological data, potential confo

192 narrow temperature ranges, E. coli tended to aggregate near a sidewall of the gradient channel at eit

193 is wherein the paramagnetic particles either aggregate near the magnet or diffusive away from the mag

194 d education level, and also differs from the aggregated network at both stages.

195 The spread of tau aggregates (neurofibrillary tangles) across the cerebral

196 sumed that social media and web portals that aggregate news restrict the diversity of content that us

197 h decreases the entropy of its states as the aggregate number of residential agents surrounded by a t

198 focus on the structures of the peptide-lipid aggregates occurring in the synergistic regime at elevat

199 The aggregate of these results expands the catalogue of qubi

200 Aggregates of a prion-like RNA-binding protein, cytoplas

201 Aggregates of alpha-synuclein in distinct synucleinopath

202 significant amount of liver inflammation and aggregates of histocytes with neutrophils within the spl

203 separation in vitro GRN-3 promoted insoluble aggregates of the TDP-43 CTD while GRN-5 mediated liquid

204 d bilayers, the hydrophobic shielding in the aggregates of these disc-shaped molecules is proposed to

205 Immune aggregates organized as tertiary lymphoid structures (TL

206 ield either complex but highly heterogeneous aggregates ('organoids') or 3D structures with less phys

207 uncertain where the initial alpha-synuclein aggregates originate.

208 the degree of oxidation, varying from fully aggregated over graphitic domains to intercalated assemb

209 ersity in space and time weakens as data are aggregated over larger areas because of the increasing d

210 roke-induced changes in network connectivity aggregated over the duration of several minutes.

211 that enables us to directly transform large aggregated particles into nanoscale materials.

212 UGT1A1 c.222C>A homozygotes followed for 520 aggregate patient-years.

213 We introduced a new metric, termed stem cell aggregate pattern distance (SCAPD) to probabilistically

214 ) percentage of cells with aggregates, (iii) aggregates per cell, (iv) area of aggregates, and (v) lo

215 icantly more circulating platelet-neutrophil aggregates (PNAs) were found in CypDplt+/+ mice.

216 itionally been limited to weakly crystalline aggregated powders, they were recently grown as micron-s

217 e family may encode disaggregases needed for aggregate processing during the earliest stages of anima

218 of metal-induced and prion-dependent protein aggregate production.

219 Autophagy degrades many of the toxic, aggregate-prone proteins responsible for such diseases,

220 anomolar affinity, and inhibits cellular Tau aggregate propagation similarly to standard porcine hepa

221 Often measured as an aggregate property of the community, BGE is highly varia

222 o remove damaged organelles and misfolded or aggregated proteins and has therefore been the subject o

223 Cytoplasmic aggregated proteins are a common neuropathological featu

224 tem cell response to increases in damaged or aggregated proteins remain unclear.

225 oss and may be associated with a build-up of aggregated proteins with altered physicochemical propert

226 on microscopy (cryo-EM) images show that new aggregates protrude from the entire length of the progen

227 In this study, we aggregated publicly available ChIP-seq data from 469 hum

228 istence of intermolecular CoIns in molecular aggregates relevant for photovoltaics.

229 earch, we found that people's creativity, on aggregate, remained constant or improved across an ideat

230 the iterations is estimated in terms of the aggregate residential homogeneity and the aggregate inco

231 Road asphalt is comprised of aggregate (rocks) mixed with a binder composed of high-b

232 ary statistical properties, as expected from aggregate sampling.

233 odel explained 61.1% of the variance in 2017 aggregate scores (p<0.0001), but we found evidence of a

234 netic field dependences up to 25 T, with the aggregates showing more drastic magnetic field sensitivi

235 annotation (MAGMA), addresses this issue by aggregating single nucleotide polymorphism associations

236 ggregates into smaller entities, restricting aggregate size [1].

237 tudies the deposition process in relation to aggregate size and structure.

238 n increasingly polar contact with decreasing aggregate size.

239 We demonstrate that aggregate SMAC-seq signals match bulk-level accessibilit

240 ersity and farm-scale spatial diversity from aggregated spatial crop diversity data if the effect of

241 We estimate that aggregate spending dropped by around 25% (95% CI: 24 to

242 The cell aggregates-spheroids-have become widely used model objec

243 These results help to explain how stem cell aggregates spontaneously self-organise into functional e

244 ) and WSA(0.5-1 mm) had a dominant effect on aggregate stability.

245 re also significantly increased water-stable aggregates stability rate (WSAR), but decreased percenta

246 This work improves our understanding of aggregated-state photoluminescence, contributes to the c

247 and CPL to derive structural information on aggregated states.

248 -ray computed tomography are used to measure aggregate structure and describe their morphology probab

249 tide, the ability to distinguish polymorphic aggregate structures, and the ability to recognize gener

250 how reduced abilities to dissociate alphaSyn aggregates, suggesting that fibril disassembly is linked

251 Soluble oligomers of aggregated tau accompany the accumulation of insoluble a

252 ence of increasing proportions of the slowly aggregating tau isoform gradually lowers the concentrati

253 lar weight species of Rnq1 and large visible aggregates that are asymmetrically retained during cell

254 hase separation in the formation of molecule aggregates that can join distant regulatory elements, su

255 sential in the reactivation of toxic protein aggregates that occur during translation or periods of s

256 a case of regeneration in Xenopus embryonic aggregates that restores a mucociliated epithelium from

257 Aggregating the testing information from each compound a

258 d that, while DOM does indeed form molecular aggregates, the large majority of molecules (especially,

259 e developed including the formation of large aggregates, the present study represents an important ad

260 ojecting them across congruent sequences and aggregating their diverse representations are critical t

261 We aggregate these data with subsaturation mutagenesis data

262 However, 2D COFs typically form insoluble aggregates, thus limiting their processing via additive

263 lar-weight aliphatic and aromatic compounds) aggregate to form complex DOM.

264 set of mutually exclusive components and was aggregated to estimate the cost-per-patient based on eac

265 odels decrease dramatically when results are aggregated to larger scales (e.g. the whole North Sea),

266 ethered mini-robots can move single cells or aggregates to build complex constructs in confined space

267 olgi network (TGN) where their soluble cargo aggregates to form a dense core, but the mechanisms cont

268 AC6 can transport ubiquitinated pathological aggregates to the MTOC for aggresome formation and autop

269 on from analyte sorption properties of small aggregates to those of bulk materials.

270 interaction term alongside a simple model of aggregate transneuronal damage.

271 The hazard ratio (HR) for the imputed aggregate treatment effects of comprehensive disease-mod

272 924 causes accumulation of misfolded protein aggregates, ultimately inducing immunogenic cell death i

273 usands of different financial assets with an aggregated valuation of more than 500 Billion USD and ty

274 ts assembly into ultra-stable decameric core aggregates via its conserved C-terminal histidine cluste

275 whether group brain activity could forecast aggregate video view frequency and duration out of sampl

276 t of these regions, however, forecasted both aggregate view frequency and duration (i.e., increased N

277 substituted BODIPY, known for forming J-type aggregates, was also encapsulated as an H-dimer.

278 ch compounds with binding affinity for polyQ aggregates, we embarked on systematic structural activit

279 rements from abandoned oil and gas wells and aggregate well counts from regional databases for the Un

280 platelet-neutrophil, -monocyte, and -T-cell aggregates were all significantly elevated in COVID-19 p

281 delivery, pathological mHTT-positive protein aggregates were distributed widely among cognitive, moto

282 The oligomeric OTUB1 aggregates were highly cytotoxic, characteristic of many

283 These aggregates were thought to act by templating the formati

284 Lactoferrin also formed disulphide-linked aggregates when it was heated with beta-lactoglobulin.

285 preparation contains significant amounts of aggregates, whereas the other preparation is essentially

286 was preceded by an increase of intracellular aggregates, which was not linked to increased translatio

287 ly shown to both inhibit formation of alphaS aggregates while simultaneously lowering toxicity.

288 s of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancer

289 Analysis of Whole Genomes Consortium, which aggregated whole-genome sequencing data from 2,658 cance

290 C) and The Cancer Genome Atlas (TCGA), which aggregated whole-genome sequencing data from 2,658 cance

291 ve to shorten while preserving connectivity, aggregate wiring length would remain low.

292 -amyloid (Abeta) species and what imbues the aggregates with such toxic potential are still not yet u

293 study of organoids, artificially grown cell aggregates with the functionality and small-scale anatom

294 model, that dissolution of calcium that has aggregated within the mitochondria of vascular smooth mu

295 In most eukaryotic algae, Rubisco aggregates within a microcompartment known as the pyreno

296 holic steatohepatitis, keratin and ubiquitin aggregates within cytoplasmic Mallory-Denk bodies, and c

297 rmation and potential stability of molecular aggregates within DOM.

298 e risk of aortic dilation of varying degrees aggregates within families.

299 Aggregated WMH risk variants were associated with altere

300 eometric mean diameter (GMD) in water-stable aggregates (WSAs) compared with CC treatment.