ライフサイエンスコーパス: aggregated

1 ignancy infected with COVID-19 have not been aggregated.

2 plants have been simplistic, emphasizing the aggregated 100-year impacts from a one-year pulse of emi

3 We hypothesized that aggregated (3-dimensional [3D]) CPCs will repair RV hear

4 erful imaging techniques to characterize the aggregated 3D culture highlighted a future methodology w

5 niques were employed to characterize a novel aggregated 3D lung adenocarcinoma model, developed by th

6 We have aggregated a comprehensive list of outcome instruments;

7 luorescent Astrophloxine was shown to detect aggregated Abeta in brain tissue and cerebrospinal fluid

8 e analysed at the country-specific level and aggregated according to country income group and the pro

9 fferences from the benchmark (residuals) are aggregated across multiple timescales using Principal Co

10 of heavy-intensity infection of less than 5% aggregated across sentinel sites, and the elimination ta

11 d into four phenotypic categories: enlarged, aggregated, aggregated and small, and decreased.

12 how that enhanced RTN-dependent clearance of aggregated Akita proinsulin helps to restore ER export o

13 Aggregated alpha-syn destabilizes the G4Q leading to unf

14 In contrast, both monomeric and aggregated alpha-syn enhance folding of the i-motif sequ

15 PD remains unclear, evidence indicates that aggregated alpha-syn fibrils are a pathogenic species in

16 syn truncations are because of the burden of aggregated alpha-syn.

17 ntra-neuronal Lewy body (LB) inclusions with aggregated alpha-synuclein (alpha-Syn) as the major comp

18 terized by the accumulation of misfolded and aggregated alpha-synuclein (alpha-syn) into intraneurona

19 by fibrillar neuronal inclusions composed of aggregated alpha-synuclein (alpha-syn).

20 transcriptionally upregulated in response to aggregated alpha-synuclein (alphaSynAgg) stimulation in

21 cation in neuronal cells can induce seeds of aggregated alpha-synuclein or DISC1 that may be able to

22 templating and spread following injection of aggregated alpha-synuclein seeds into brain, supporting

23 Aggregated alphaSyn has been shown to induce ER stress a

24 Aggregated amyloid beta (Abeta) peptides in the Alzheime

25 The formation of amyloid plaques by aggregated amyloid beta (Abeta) peptides is a primary ev

26 ate as the biological effects of soluble and aggregated Amyloid-beta peptides are difficult to separa

27 th according to each strategy and then in an aggregated analysis (LDR versus triple therapies).

28 tals' PIPES indices were computed; data were aggregated and analyzed for geographic and private/publi

29 patient-based glaucoma Facebook groups were aggregated and analyzed using the search criteria.

30 We use aggregated and anonymized information based on internati

31 surrender to host spatial control, becoming aggregated and entrapped within the lumen.

32 and prestin protein lacking exons 17 and 18 aggregated and failed to target the cell membrane.

33 Tau protein is found to be aggregated and hyperphosphorylated (p-tau) in many neuro

34 ApoE4 is more aggregated and hypolipidated compared with ApoE3, but wh

35 Together, our data demonstrate that aggregated and lipid-poor ApoE4 increases ABCA1 aggregat

36 In the first experiment, we extracted aggregated and longitudinal features from EHR.

37 th its Hsc70 partner to recognize and manage aggregated and misfolded proteins.

38 pathways by promoting the formation of more aggregated and nontoxic tau aggregates.

39 action over time led to clusters with highly aggregated and phosphorylated DDR1.

40 thology, resulting from multiple causes, was aggregated and referred to, in toto, as the pathology 'c

41 phenotypic categories: enlarged, aggregated, aggregated and small, and decreased.

42 The fabrication of non-aggregated and uniformly-sized nanodiamonds with systema

43 n the material from the various sections was aggregated, and the leader of the task force (J.D.S.) me

44 We aggregated annotations across all (respectively blood or

45 ol efflux activity and greater percentage of aggregated ApoE protein compared with CSF from APOE epsi

46 the formation of intranuclear inclusions of aggregated AR.

47 proteinase K (PK)-resistant, insoluble, and aggregated assemblies that were infectious for naive cel

48 us, the predictability of activity variation aggregated at a daily scale, and the clear signal that b

49 he U.S., demographic data are only available aggregated at county or coarser scales, so disease model

50 dients with wide temperature ranges, E. coli aggregated at intermediate temperatures, with maximal ce

51 ication, and quarter (date of case reporting aggregated at three-month intervals) explained 93.6% of

52 ve binomial regression applied to nationally aggregated AU data from locations reporting >=9 months o

53 uption was more pronounced for slow-growing, aggregated bacteria than for fast-growing, planktonic sp

54 for early detection of AD biomarkers such as aggregated beta-amyloid and tau proteins.

55 ed to a denser microstructure with increased aggregated beta-sheet structure and a firmer cheese.

56 ld into compact regions, likely representing aggregated bipolar cell inputs.

57 oci by myosin motors or more slowly (30 min) aggregated by crowding.

58 uency, <=5%) measured by an exome array were aggregated by genes and evaluated by a gene-environment

59 multivariable logistic regression models and aggregated by the two-level individual participant data

60 table dispersion to the partially- and fully-aggregated cases and results in an attendant improvement

61 values, combined test statistics such as the aggregated Cauchy association test (ACAT) can also be ut

62 Here we propose an aggregated Cauchy association test (ACAT), a general, po

63 robing the chromatin landscape of single and aggregated cells.

64 The ClpB-DnaK bichaperone system reactivates aggregated cellular proteins and is essential for surviv

65 plain up to 50% of the variation in district-aggregated changes in wealth over time, with daytime ima

66 f future climatic changes rely on seasonally aggregated, coarse-resolution data.

67 Census tracts with more connected, aggregated, coherent, and complex shape greenspaces had

68 rotein-rich bio-solutions where conventional aggregated colloids fail.

69 cell imaging and differentiation of complex aggregated conformations in live cells.

70 Prion strains are aggregated conformers that stably propagate in vivo and

71 e (WOSR) yield variation through analysis of aggregated country-wide on-farm yield data and in annual

72 On-bead TMR-labeled alpha-synuclein and aggregated Cy5-labeled alpha-synuclein from the solution

73 We further aggregated data from 1498 patients with DCM sequenced in

74 cutaneous transluminal angioplasty (PTA), we aggregated data from 2 RCTs comprising 419 patients trea

75 of more than 500 000 participants, which has aggregated data from questionnaires, physical measures,

76 reconstruction persist at 1 to 2 years, with aggregated data indicating considerably lower risks of e

77 data for 110 (~80%) species in the group and aggregated data layers for body shape, habitat occupancy

78 Aggregated data on any enterovirus detected between Jan

79 nvironmental parameters and more than 50,000 aggregated data points of measured groundwater arsenic c

80 Aggregated data were provided by representatives from 24

81 econstructions of marine fishing fleets have aggregated data without regard to the artisanal and indu

82 1990 to March 1, 2018) for clinical studies (aggregated data) or surveys (individual participant data

83 were compared to the prospectively collected aggregated data.

84 ds screened, 57 studies were included in the aggregated-data meta-analysis (including 59 457 births).

85 the recognition that childhood asthma is an aggregated diagnosis that comprises several different en

86 facilitate its action to clear intranuclear, aggregated disease proteins like HTT.

87 tematically higher (implying more temporally aggregated distributions) along hydrographic boundaries.

88 We isolated aggregated Drosophila CPEB, Orb2, from adult heads and d

89 Aggregated drug resistance data reported to WHO from eit

90 Addition of CQDs into AuNPs, gets them aggregated due to electrostatic interaction resulting in

91 ze fractions from unclean lab-ware, dust and aggregated & dynamically aggregating sample, for example

92 water-stress prone cropland, and estimate an aggregated economic loss impact of $536M USD yr(-1), 4.0

93 ttle attention has been given to whether the aggregated effect of energy transitions poses a substant

94 from complex-trait studies to show that the aggregated effect of putative passengers, including unde

95 In contrast, aggregated endodermal cells persistently lose epithelial

96 Results The aggregated energy consumption imaging 40 276 patients am

97 catalytic domain (V142M and P150A) generated aggregated enzymes that could not be refolded after solu

98 ying amyotrophic lateral sclerosis (ALS), we aggregated exomes from 3,864 cases and 7,839 ancestry-ma

99 ffected parents, as well as more than 60,000 aggregated exomes from the Exome Aggregation Consortium,

100 urthermore, platelets from COVID-19 patients aggregated faster and showed increased spreading on both

101 were also compared to analogous conventional aggregated features to evaluate the potential advantage

102 Here anonymous and aggregated flows generated from three hundred million us

103 onally intensive molecular simulations to be aggregated for downstream functional analysis, and facil

104 The aggregated form of alpha-syn is well known for its role

105 attributed to the transformation of the non-aggregated form of AuNPs to its aggregated form upon bin

106 sequestration of the poly-ubiquitinated and aggregated form of mutant TDP-43, which correlated with

107 Scrapie prion protein is a misfolded and aggregated form of PrP(C) responsible for prion-induced

108 n of the non-aggregated form of AuNPs to its aggregated form upon binding of the biomarkers.

109 ore acute cytotoxicity than the soluble, non-aggregated form.

110 unusual properties, such as specificity for aggregated forms of the peptide, the ability to distingu

111 Cellular accumulation of aggregated forms of the protein tau is a defining featur

112 In an additional analysis, data were aggregated from 6 poolable Stellarex DCB studies (2 RCTs

113 d in light of prior information about genes, aggregated from numerous knowledge bases and encoded in

114 we describe global human mobility patterns, aggregated from over 300 million smartphone users.

115 total and nine of 12 adjusted monthly totals aggregated from the latest version of the high-resolutio

116 erview, a list of radiology AI companies was aggregated from the Radiological Society of North Americ

117 umes the functional annotations of genes are aggregated from those of key isoforms.

118 ere, we present SAFE-clustering, single-cell aggregated (From Ensemble) clustering, a flexible, accur

119 We used aggregated genome-wide association data (N = 110,347 for

120 to predict species losses after random, but aggregated, habitat loss.

121 An aggregated hierarchical conformal predictor applied to a

122 tor CD36, regulates the microglial uptake of aggregated human alpha-synuclein (alphaSyn), which is th

123 ces in overall microbiota diversity in group-aggregated human APOE genotypes.

124 eta) and neurofibrillary tangles composed of aggregated, hyperphosphorylated tau.

125 IL3-primed blood eosinophils seeded on heat-aggregated immunoglobulin G (HA-IgG).

126 single-cell resolution and then signals were aggregated in each cell population separately.

127 Tau-related alterations aggregated in large genomic segments reflecting spatial

128 structural and functional features have been aggregated in MISCAST from multiple databases, and displ

129 ere termed food set selection) was spatially aggregated in patches and how food aggregation varied ac

130 A large part of the variant level data is aggregated in public databases such as ClinVar.

131 y epidemic alert systems are typically fully aggregated in space at the national level.

132 Acetylcholine receptors are aggregated in the central regions of intrafusal muscle f

133 ), as a bona fide ERAD substrate that became aggregated in the endoplasmic reticulum following ERAD d

134 from human tissue in comparison with fibrils aggregated in vitro.

135 and categorizations of socioeconomic status, aggregated individual socioeconomic data using large geo

136 ded similar mean ARS (IFD); however, ARS for aggregated individuals declined near the periphery (GSH)

137 nia is best approximated by a logseries with aggregated individuals, where aggregation increases with

138 Notably, a meta-analytical approach that aggregated information across teams yielded a significan

139 In addition, analysis of aggregated (insoluble) proteins showed they are extensiv

140 to cirrhosis, to test whether such variants, aggregated into a polygenic score, enable genomic risk s

141 Aggregated into a polygenic score, these variants identi

142 ence data for humans have traditionally been aggregated into low-resolution data sets, modern represe

143 ework in which regulatory variants are first aggregated into sets, and using these as estimates of th

144 ased on the exact mass of the most-abundant (aggregated) isotope peak, which is a robust measure of m

145 either anti-cataractogenic activity or bind aggregated lens protein to dissolve cataracts.

146 lts by crop are consistent with those at the aggregated level except for vegetables of which water us

147 nalysis was performed on a large database of aggregated, longitudinal, de-identified electronic medic

148 to which a suspended bacterial population is aggregated mainly rely on: (1) cell size distribution cu

149 ological multifunctionality framework (i.e., aggregated measures of the ability of ecosystems to simu

150 othermites by rapidly melting and coalescing aggregated metal nanoparticles, which increases the init

151 ons we demonstrate the redispersion of large aggregated metal oxide particles into metallic nanoparti

152 F mutation results in autoantibodies against aggregated misfolded protein with immune complex formati

153 The intracellular accumulation of aggregated misfolded proteins is a cytopathological hall

154 Moreover, the particle size of the aggregated molecules gradually increased with the change

155 entially involved in the energy transport in aggregated molecules or polymers but are yet to be uncov

156 Community-aggregated monthly MiP cases were downloaded from Health

157 Aggregated monthly use was measured in days of therapy p

158 UBQLN2 specifically reduced accumulation of aggregated mutant HTT but not mutant ATXN3 in mouse mode

159 we investigated whether PRIMA-1 can restore aggregated mutant p53 to a native form.

160 ers with the PNPs induce dispersed or weakly aggregated nanocomposite morphologies, depending on the

161 y structure of PEO-b-PS can be tailored from aggregated nanoparticles to hollow spheres even mesoporo

162 reventing sedimentation by encapsulating the aggregated nanospheres with polyvinylpyrrolidone, thereb

163 is still unclear, especially considering its aggregated nature and the resulting low diffusivity of i

164 ic septate-like junctions between abnormally aggregated nephrocytes.

165 Aggregated nesting events, termed 'arribadas', involve h

166 d education level, and also differs from the aggregated network at both stages.

167 r aggregation pathways, converting to a more aggregated non-toxic state as assessed in the human neur

168 ore attractive to mosquitoes, and mosquitoes aggregated on the cue at all non-noxious temperatures.

169 l context using individual caribou that were aggregated or disaggregated during calving and varied in

170 rs of the pride when prey herds were scarce, aggregated or large bodied, and associating more exclusi

171 thynyl)benzene (BAB)-based highly emissive J-aggregated organogel has been synthesized and characteri

172 of 916 AA RA patients and 1392 controls and aggregated our data with genotyping data from >100 000 E

173 We aggregated our results with a meta-analysis of a wide ra

174 a quality metrics, visualization tracks, and aggregated output for further downstream analysis.

175 the degree of oxidation, varying from fully aggregated over graphitic domains to intercalated assemb

176 ersity in space and time weakens as data are aggregated over larger areas because of the increasing d

177 roke-induced changes in network connectivity aggregated over the duration of several minutes.

178 The aggregated particles exhibit different fluorescence emis

179 that enables us to directly transform large aggregated particles into nanoscale materials.

180 morphological variations in fibril states of aggregated peptides and proteins.

181 trate that cytoplasmic inclusions containing aggregated phosphorylated TDP-43 can evolve through thre

182 g telemetry data that explicitly includes an aggregated physiological process associated with decisio

183 each), with increased precision expected for aggregated population totals in larger areas.

184 hen SSB demand may be more inelastic, and 2) aggregated posttax time points to address serial correla

185 itionally been limited to weakly crystalline aggregated powders, they were recently grown as micron-s

186 nfluenza-like illness surveillance data with aggregated prescription data.

187 Given temporally and spatially aggregated prey, filter feeding provides an evolutionary

188 assays for detecting their conversion to an aggregated prion conformation.

189 major component of Lewy bodies, the typical aggregated protein deposits found in Parkinson's disease

190 some justification for the increased use of aggregated protein equations in recent plant clock model

191 onditions a minor population of specifically aggregated protein molecules are present.

192 o remove damaged organelles and misfolded or aggregated proteins and has therefore been the subject o

193 Cytoplasmic aggregated proteins are a common neuropathological featu

194 nafter) is a process by which organelles and aggregated proteins are delivered to lysosomes for degra

195 We set out to understand how aggregated proteins are managed during infection-related

196 the absence of Hsp104 disaggregase activity, aggregated proteins are spatially sequestered into quali

197 DBeQ inhibited the reactivation of aggregated proteins by the ClpB-DnaK bichaperone system

198 tively compromising the ability to eliminate aggregated proteins is a pathogenic driver, and the sele

199 ce, whether metazoan mitochondria reactivate aggregated proteins is unknown.

200 The inter- and intracellular propagation of aggregated proteins like tau is emerging as a central me

201 tem cell response to increases in damaged or aggregated proteins remain unclear.

202 adative vesicles carrying aged organelles or aggregated proteins take the opposite route, driven by d

203 y characterized is targeting of misfolded or aggregated proteins to degradation pathways, including t

204 um, which makes it suitable for the study of aggregated proteins when accumulated as a layer close to

205 oss and may be associated with a build-up of aggregated proteins with altered physicochemical propert

206 me when NSCs are required to clear a wave of aggregated proteins, and demonstrate an early age-depend

207 aracterized by distinct molecular classes of aggregated proteins, the most common being TAR DNA-bindi

208 erized by a slow, persistent accumulation of aggregated proteins.

209 g cell types and are potentially enriched in aggregated proteins.

210 regulated removal of damaged, misfolded, or aggregated proteins.

211 nt that is promoted in the presence of other aggregated proteins.

212 In this study, we aggregated publicly available ChIP-seq data from 469 hum

213 onses can cause patterns of damage to become aggregated, random or even.

214 We aimed to characterize the role of aggregated rare and low-frequency protein-coding variant

215 Given this perspective, our group aggregated regional volumes data of 68 cortical regions

216 he absence of Mam33 results in misassembled, aggregated ribosomes and a respiratory lethal phenotype

217 we characterize super-enhancer regions using aggregated RNA sequencing (RNA-seq) data from large coho

218 cterium Synechococcus elongatus (Se) to form aggregated Rubisco complexes with the carboxysome linker

219 To support epitope selection, we provide an aggregated score of expected therapeutic efficiency as a

220 We also found that the levels of aggregated SOD1 in the spinal cord were inversely correl

221 D1 may be the disease driver in ALS, whereas aggregated SOD1 may serve to sequester the toxic species

222 gions least affected by disease had the most aggregated SOD1.

223 sfolded and nonnative disulfide-cross-linked aggregated SOD1.

224 onships between the different SOD1 variants (aggregated, soluble misfolded, soluble total) and the cl

225 ersity and farm-scale spatial diversity from aggregated spatial crop diversity data if the effect of

226 amyloid-beta symbol (Abeta) peptide but with aggregated species.

227 can induce the conversion of LEF-10 into an aggregated state in virus-infected cells, resulting in t

228 conversion of soluble protein species to an aggregated state.

229 This work improves our understanding of aggregated-state photoluminescence, contributes to the c

230 uminescence, CPL, provide tools for studying aggregated states and the key properties to be sought fo

231 itions between the assembled, dispersed, and aggregated states of these nanosheets can be triggered b

232 ult to elucidate because of the diversity of aggregated states they can adopt.

233 While several final aggregated states-notably amyloids-have been characteriz

234 and CPL to derive structural information on aggregated states.

235 crease in alpha- helices, and an increase in aggregated strands, random coils and aromatic side chain

236 uctures was complemented with an increase in aggregated strands.

237 hydrolysis to solubilize proteins trapped in aggregated structures.

238 patients using a standardised data form for aggregated study-level data.

239 rizes into active hexamers that resolubilize aggregated substrates using ATP and without the aid of p

240 and cognitive decline, making the imaging of aggregated tau a compelling biomarker.

241 Soluble oligomers of aggregated tau accompany the accumulation of insoluble a

242 nses, we hypothesized that the appearance of aggregated tau and p-tau with disease could activate the

243 Abnormal intracellular accumulation of aggregated tau is a hallmark feature of Alzheimer's dise

244 rly as two decades before the development of aggregated tau pathology.

245 zheimer's disease, the density and spread of aggregated tau protein track well with neurodegeneration

246 -64326067), a potent and selective binder to aggregated tau with a favorable pharmacokinetic profile

247 a PET tracer with high binding affinity for aggregated tau, a key pathologic feature of Alzheimer di

248 (PET) tracer with high binding affinity for aggregated tau, a key pathologic feature of Alzheimer's

249 This supports the notion that aggregated taxon-specific responses may better reflect t

250 Aggregated TDP-43 does not retain its physiological func

251 e of ALS is cytoplasmically mislocalized and aggregated TDP-43 protein in >95% of cases, which is con

252 Although aggregated TDP-43 protein moves between cells, it is not

253 opulation is indeed recruited to SGs, mature aggregated TDP-43, produced with aggregate-prone TDP-43

254 cal testicular dysgenesis were present in re-aggregated testis, including ectopic Sertoli cells and i

255 within the artificial slope, which naturally aggregated the crushed grains.

256 When aggregated, the predicted relationship between income in

257 We aggregated this information to the state (n = 36) and di

258 ontrast, under fed conditions, nanoparticles aggregated to 60 +/- 10 nm in the stomach, then disaggre

259 Under fasted stomach conditions, particles aggregated to D(h) = 130 +/- 10 nm and remained as large

260 rogen produced in individual facilities were aggregated to develop emission values for both a nationa

261 set of mutually exclusive components and was aggregated to estimate the cost-per-patient based on eac

262 At the same time, host cell F-actin aggregated to form a globular-shaped plug beneath the Cp

263 positions, they cannot be easily compared or aggregated to global impacts.

264 odels decrease dramatically when results are aggregated to larger scales (e.g. the whole North Sea),

265 mogeneous) thermostatically controlled loads aggregated to provide the demand response (DR) services

266 yses were done at the country level and then aggregated to seven regions: World Bank high-income coun

267 cale (<1km(2)) tundra heterogeneity is often aggregated to the dominant land cover unit.

268 rs conducted a GWAS meta-analysis and probed aggregated Tourette's syndrome polygenic risk to test wh

269 on or monoclonal antibodies directed against aggregated, toxic alpha-synuclein.as well as anti-aggreg

270 Systemic amyloid deposition of aggregated transthyretin causes hereditary and sporadic

271 We aggregated U.S. state, city, and business commitments wi

272 the macroscopic level demonstrates that the aggregated urban quantities (e.g., gross domestic produc

273 Aggregated uromodulin may induce dendritic cell toleranc

274 ed high levels of intracellular and secreted aggregated uromodulin, resulting in anti-uromodulin anti

275 usands of different financial assets with an aggregated valuation of more than 500 Billion USD and ty

276 Still, for any given pixel it is a global, aggregated value, that makes impossible the individual a

277 than the extremes estimated using seasonally aggregated variables.

278 in well-defined geographical locations; and aggregated virus results at least on a monthly basis.

279 We then used the aggregated VTA-based outcome maps to rate patient indivi

280 from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential vir

281 r compared to the models with growing season aggregated weather variables and show the strength of Ba

282 han the predicted impacts of the models with aggregated weather variables.

283 s of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cance

284 s of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancer

285 s of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancer

286 s of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancer

287 s of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancer

288 s of Whole Genomes (PCAWG) Consortium, which aggregated whole-genome sequencing data and RNA sequenci

289 C) and The Cancer Genome Atlas (TCGA), which aggregated whole-genome sequencing data from 2,658 cance

290 C) and The Cancer Genome Atlas (TCGA), which aggregated whole-genome sequencing data from 2,658 cance

291 Analysis of Whole Genomes Consortium, which aggregated whole-genome sequencing data from 2,658 cance

292 s of Whole Genomes (PCAWG) Consortium, which aggregated whole-genome sequencing data from 2658 cancer

293 s of Whole Genomes (PCAWG) consortium, which aggregated whole-genome sequencing data from 2658 cancer

294 hPGCLCs are aggregated with mouse embryonic ovarian somatic cells to

295 Au/Ag colloids aggregated with simple salts are amongst the most common

296 ls reseeded onto micro-discs were motile and aggregated with the same but segregated from distinct ce

297 neurons and human AD brain, HDAC6 becomes co-aggregated within focal tau swellings and human AD neuri

298 ontrol samples from 36 different tumor types aggregated within the ICGC/TCGA Pan-Cancer Analysis of W

299 model, that dissolution of calcium that has aggregated within the mitochondria of vascular smooth mu

300 Aggregated WMH risk variants were associated with altere