ライフサイエンスコーパス: aging process

1 sistance pathways as critical players in the aging process.

2 hological conditions such as cancer, and the aging process.

3 mmasome-mediated caspase-1 activation in the aging process.

4 and why we age-and possibly how to delay the aging process.

5 ential influences of social adversity on the aging process.

6 ne DNA methylation is compromised during the aging process.

7 variants or networks that contribute to the aging process.

8 sights into the role age-dMS may have in the aging process.

9 h through a range of diseases and the normal aging process.

10 rities between the fibrotic disorder and the aging process.

11 malian health, and perhaps in modulating the aging process.

12 occurrence and hormonal activity during the aging process.

13 ong-term protein persistence to the cellular aging process.

14 rlie the central role of mitochondria in the aging process.

15 trophes but also rescues and can reverse the aging process.

16 f biological systems is the true root of the aging process.

17 changes of some key proteins relevant to the aging process.

18 may lead to new insights into the human skin aging process.

19 hibit oil-wet conditions through a crude oil aging process.

20 GnRH neuronal output is modulated during the aging process.

21 the best-understood proteins involved in the aging process.

22 tion, or a matrix metalloproteinase-mediated aging process.

23 sease encompasses more than just the natural aging process.

24 hat the 4 allele may particularly affect the aging process.

25 re help to uncover general principles of the aging process.

26 precedented microscopic imaging of the whole aging process.

27 nature of the CSF proteome during the normal aging process.

28 ls, a radical shift in our perception of the aging process.

29 age-related diseases is that it inhibits the aging process.

30 m and in the systemic adjustments during the aging process.

31 y cohort allowed agent-based modeling of the aging process.

32 In contrast, MCAK eliminated the aging process.

33 for memory deficits that often accompany the aging process.

34 o how progerin may participate in the normal aging process.

35 monodisperse product by means of a prolonged aging process.

36 existing pipelines to better understand the aging process.

37 plays a role in disease development and the aging process.

38 anges with alterations that occur during the aging process.

39 on skin are also reminiscent of the natural aging process.

40 cline is a virtually universal aspect of the aging process.

41 letions, which have been associated with the aging process.

42 ur in subjects with schizophrenia during the aging process.

43 normal chromatin packing contributes to the aging process.

44 om the intervening disease to the underlying aging process.

45 ations that can prevent, stop or reverse the aging process.

46 s one of the most distressing aspects of the aging process.

47 en proposed to play an important role in the aging process.

48 as a viable method to curtail the cognitive aging process.

49 s network of communication may relate to the aging process.

50 t-6 play an important functional role in the aging process.

51 res are considered integrated markers of the aging process.

52 e progressively more prooxidizing during the aging process.

53 d, potentially, for our understanding of the aging process.

54 immune declines associated with the natural aging process.

55 e an effect on metabolic pathways during the aging process.

56 he correlation between tumorigenesis and the aging process.

57 he thermodynamically favored shape during an aging process.

58 spond to central energy needs throughout the aging process.

59 ects during fetal development and during the aging process.

60 ausing similar mitotic defects in the normal aging process.

61 re both conserved across species to regulate aging process.

62 es are an integral part of the physiological aging process.

63 lammatory processes that increase during the aging process.

64 described as being associated with premature aging process.

65 tic histone methyltransferase Suv39h1 in the aging process.

66 g-term outcome for several indicators of the aging process.

67 ormal growth and development and also in the aging process.

68 useful in monitoring and intervening in the aging process.

69 , indicating that these compounds retard the aging process.

70 ong-lived, has its natural limitation in the aging process.

71 r signal transduction at synapses during the aging process.

72 ikely a result of acceleration of the normal aging process.

73 n protein oxidation were changing during the aging process.

74 ecules are believed to play key roles in the aging process.

75 controls, during oxidative stress and early aging process.

76 nuclear architecture occur during the normal aging process.

77 s of the LDT and PPT as a consequence of the aging process.

78 are thought to be a major contributor to the aging process.

79 rom rare, inborn errors of metabolism to the aging process.

80 e phenotypic biomarker and a hallmark of the aging process.

81 Klotho is downregulated as part of the aging process.

82 gly associated with several diseases and the aging process.

83 years as the most accurate biomarkers of the aging process.

84 hether this is a cause or consequence of the aging process.

85 ple develop presbyopia as part of the normal aging process.

86 in sleep pattern are typical for the normal aging process.

87 ssion of cancer and diabetes, as well as the aging process.

88 ins and Klotho, which further accelerate the aging process.

89 unction may be particularly sensitive to the aging process.

90 length and, therefore, potentially with the aging process.

91 ment and also plays an important role in the aging process.

92 s been recognized as a causal factor for the aging process.

93 ne and the nuclear lamina contributes to the aging process.

94 d as an effective approach to delay the skin aging process.

95 ar how GAG structures are changed during the aging process.

96 andom attacks and thus may contribute to the aging process.

97 neurodegenerative diseases, and the general aging process.

98 ity of NiS in surface sediments early in the aging process.

99 es over a lifetime as part of an "epigenetic aging" process.

100 nation of changing sources and photochemical aging processes.

101 ated marker compound that is associated with aging processes.

102 t and differentially vulnerable to normative aging processes.

103 at the crossroads of genomic instability and aging processes.

104 unknown disease, cellular heterogeneity and aging processes.

105 n cellular energy metabolism, apoptosis, and aging processes.

106 ysregulations during normal and pathological aging processes.

107 ithin the brain are also highly sensitive to aging processes.

108 to genetic manipulations that slow down the aging process?

109 mutation frequency and tumorigenesis in the aging process?

110 omatous tissues supports that an accelerated aging process accompanies neurodegeneration in glaucomat

111 ly sensitive to both normal and pathological aging processes across adulthood.

112 The aging process affects all aspects of the immune system,

113 It is currently not known whether the aging process affects the response to injury of cholangi

114 c insults, and also involutes as part of the aging process, albeit at a faster rate than many other t

115 However, the aging process also occurs in dividing cells undergoing r

116 d elevated, resulting in a highly compressed aging process and accelerated formation of several prote

117 he molecular pathways that contribute to the aging process and age-related disease is progressing thr

118 extracellular matrix, all implicated in the aging process and age-related disease risk.

119 sults suggest a mechanistic link between the aging process and aggregation-mediated proteotoxicity.

120 ng prospects for medical intervention in the aging process and also suggest different approaches in a

121 tions about, and exclusive reference to, the aging process and any associated disease.

122 t due to the implication of telomeres in the aging process and cancer.

123 ecause of its involvement in both the normal aging process and common human diseases.

124 showing that dietary restriction delays the aging process and decreases the incidence of many age-as

125 he complex role of metabolic pathways in the aging process and highlight important paradoxes that hav

126 d cellular signaling events that control the aging process and how can this knowledge help design the

127 is establishes a role for endo siRNAs in the aging process and identifies downstream genes and physio

128 ed signaling through this pathway during the aging process and in OA chondrocytes is known to contrib

129 it is possible to therapeutically target the aging process and increase health span.

130 d lifestyle are known factors modulating the aging process and insulin resistance/secretion, determin

131 e a system of four stages that describes the aging process and is useful for the analysis of genetic

132 ons, with a focus on vascular aspects of the aging process and its cardiovascular disease related man

133 omarkers provide detailed description of the aging process and its contribution to Alzheimer's diseas

134 goal of broadening our understanding of the aging process and its meaning as a 'risk factor' in dise

135 However, a mechanistic understanding of the aging process and its role in ionic nutrient adsorption

136 ized form of amyloidosis associated with the aging process and may be of pathophysiologic import.

137 drial dysfunction is a core component of the aging process and may play a key role in atherosclerotic

138 ntribute to organ dysfunctions including the aging process and other disease processes.

139 iated ALS, with possible applications to the aging process and other late-onset neurodegenerative dis

140 model highlights specific components of the aging process and provides a quantitative readout for st

141 o the role of somatic mtDNA mutations in the aging process and raise the specter of progressive iatro

142 n structure is critical for slowing down the aging process and reveals that increasing the histone su

143 Furthermore, we show that the normal aging process and Sotos syndrome share methylation chang

144 ence for phosphate toxicity accelerating the aging process and suggest a novel role for phosphate in

145 ions offer valuable insights into the normal aging process and the complex biology of cardiovascular

146 lifespan could offer insights into both the aging process and the development of aging-related neuro

147 nduced gene regulation may contribute to the aging process and the premature aging in WS.

148 at amyloid-like aggregates contribute to the aging process and therefore could be important targets f

149 The natural aging process and traumatic events such as lower-limb lo

150 Cellular senescence is a primary aging process and tumor suppressive mechanism characteri

151 Klotho is a key modulator of the aging process and, when overexpressed, extends mammalian

152 since telomere attrition is associated with aging processes and accelerates after a recurrent exposu

153 me of reinforcement that is similar for both aging processes and BW813U administration.

154 Calorie restriction (CR) influences aging processes and extends average and maximal life spa

155 gen species, are both associated with normal aging processes and linked to cardiovascular disease, ca

156 Understanding BBA aging processes and quantifying the size-resolved mass a

157 mediator of both cholangiocyte adaptation to aging processes and response to injury.

158 Aging processes and surface contamination especially wit

159 Advances in understanding aging processes and their consequences are leading to th

160 t for both better comprehension of cognitive aging processes and will aid in the development of succe

161 cumulated throughout life, contribute to the aging process, and that burden of ultra-rare variants in

162 ion in stress tolerance is a hallmark of the aging process, and the lowered functional capacity obser

163 The mechanisms underlying the aging process are not understood.

164 Skin aging processes are modeled by treating keratinocytes wi

165 Aging processes are ubiquitous and play a fundamental ro

166 f genes and molecular pathways to aging, the aging process as a whole still remains poorly understood

167 NF-L) were found to be characteristic of the aging process as reported in vivo.

168 emonstrated to ameliorate and decelerate the aging process as well as blunt end organ damage from obe

169 eport increased forgetfulness earlier in the aging process, as they transition to menopause.

170 We studied adults early in the aging process, as women transition into menopause, to id

171 vulnerability to unhealthy developmental and aging processes, as exemplified by schizophrenia and Alz

172 ather, stalk LD-transpeptidation reflects an aging process associated with low peptidoglycan turnover

173 To define the C. elegans aging process at the molecular level, we used DNA microa

174 c and treatment strategies that may slow the aging process based on the unique biochemistry of each i

175 asis should be placed on research into basic aging processes, because interventions that slow aging w

176 ed NAD homeostasis that accompany the normal aging process but also, elucidate the merits and potenti

177 The results offer insights into the aging process, but also offer a new approach to studying

178 em may not entirely be due to a degenerative aging process, but are the result of developmental and s

179 Mitochondria deteriorate during the aging process, but the underlying mechanisms for the dec

180 oxic dose-response by H. azteca early in the aging process; but only Burntwood, for which Ni was prim

181 interorgan macroenvironment can regulate the aging process by integrating both "activator" and "inhib

182 e that protein quality control exerts on the aging process by using CHIP-/- mice.

183 The aging process can be recapitulated by Col17a1 deficiency

184 Here, we investigated whether the aging process can induce changes in the myocardial GAG c

185 Identifying factors that accelerate the aging process can provide important therapeutic targets

186 advances suggest that targeting fundamental aging processes can delay, prevent, or alleviate age-rel

187 rly adulthood, which suggests an accelerated aging process compared with other postmitotic tissues.

188 deterioration of meiotic cohesion during the aging process compromises the segregation of achiasmate

189 productive lifespan (PRLS), during which the aging process continues.

190 osteoarthritis and the understanding of how aging processes contribute to the development of osteoar

191 translational research to understand how the aging process contributes to the onset and/or progressio

192 The accumulation of loose deposits and the aging process create variable microenvironments inside l

193 Sirtuins (SIRTs), central regulators of the aging process, decrease during normal aging and in aging

194 The aging process deleteriously alters the structure and fun

195 We chose ERCC6 because of its roles in the aging process, DNA repair, and ocular degeneration from

196 e locally generated particles, together with aging processes, dramatically affected aerosol compositi

197 framework for asking new questions about the aging process emerges.

198 ic restriction (CR) has been shown to retard aging processes, extend maximal life span, and consisten

199 Over the course of the aging process, fibroblasts lose contractility, leading t

200 hat resemble premature aging--and the normal aging process has been a source of debate in the aging r

201 es cancer development and contributes to the aging process has progressed rapidly.

202 nse to high-fat diet regimens and during the aging process; however no studies to date have elucidate

203 potential role of dairy foods in the ovarian aging process; however, no prior epidemiologic studies h

204 have identified major roadblocks that normal aging processes impose on tissue regeneration.

205 The aging process imposes a threat to diversity, because thy

206 phosphorylation diminished during the normal aging process in both humans and flies.

207 patterns that are highly correlated with the aging process in both of the two species.

208 nsive understanding of the dynamic metabolic aging process in brain can provide insights into windows

209 ranscriptional circuit that guides the rapid aging process in C. elegans and indicate that this circu

210 nfluences DAF-16-dependent regulation of the aging process in C. elegans by regulating the transcript

211 ine the expression of SK channels during the aging process in GnRH neurons.

212 ments of HPA regulation are intrinsic to the aging process in hominids and are side effects neither o

213 ermine if calorie restriction attenuates the aging process in humans.

214 First described as regulators of the aging process in invertebrate model organisms, Forkhead

215 esults would predict that MsrA regulates the aging process in mammals.

216 SIR2 is a key regulator of the aging process in many model organisms.

217 Metabolic imbalances accompany the aging process in many organisms, and signaling mechanism

218 The aging process in rodents is associated with learning and

219 Although the intrinsic aging process in skin is phenotypically distinct from SS

220 Caloric restriction retards the aging process in small mammals; however, no information

221 Among these, the aging process in the central nervous system is criticall

222 omeostasis with perturbations induced by the aging process in the function of the main intracellular

223 ed signatures, thus allowing modeling of the aging process in vitro, and they identify impaired NCC a

224 c brown carbon; however, their formation and aging processes in atmospheric waters are unknown.

225 Not all osteoarthritis is due to aging processes in joint tissues, but the age-related ch

226 ore the potential role of BFSP1 and BFSP2 in aging processes in the lens.

227 k implicates disruptions to the normal brain aging processes in the pathology of schizophrenia and de

228 ondria contribute to specific aspects of the aging process, including cellular senescence, chronic in

229 adult and aged rats and suggest that taking aging processes into account when assessing stroke may i

230 sease processes of clinical interest and the aging process involve oxidative stress in their underlyi

231 t that impaired erectile function during the aging process involves increased RhoA/Rho-kinase signali

232 f wild type and "aged" NmHO reveal that the "aging" process involves cleavage of the Arg208His209 dip

233 to generate transcriptional profiles of the aging process is a powerful tool for identifying biomark

234 A cellular mechanism postulated to drive the aging process is cellular senescence, mediated in part b

235 While the aging process is central to the pathogenesis of age-depe

236 The aging process is characterized metabolically by insulin

237 rown fat activity observed during the normal aging process is currently unknown.

238 In the present study, the aging process is experimentally mimicked in the laborato

239 dies in model organisms demonstrate that the aging process is frequently modified by an organism's ab

240 The central importance of epigenetics to the aging process is increasingly being recognized.

241 potentially early event in the normal human aging process is microsatellite instability accumulation

242 ermining if a given intervention affects the aging process is not straightforward since, for instance

243 nt and identity of epigenetic changes in the aging process is therefore potentially important for und

244 her a cloned animal undergoes an accelerated aging process is yet to be answered.

245 aging, research suggests that targeting the aging process itself could ameliorate many age-related p

246 Animal experiments also reveal that the aging process itself, in the absence of significant nois

247 et pathways specifically associated with the aging process itself.

248 athways, and reflect on which aspects of the aging process may be reversible.

249 ies to intervene in aspects of the stem cell aging process may have significant clinical relevance.

250 Therapeutic targeting of the aging process may therefore represent an innovative stra

251 Therapeutic approaches that target aging processes may be beneficial for halting the progre

252 In conclusion, skin aging processes may involve ROS-induced protein dysfunct

253 o explain how protein aggregation and normal aging processes might be involved in polyglutamine disea

254 es of nuclear architecture during the normal aging process of a multicellular organism, but also sugg

255 election approach, using as a case study the aging process of cachaca.

256 if collagen plays a significant role in the aging process of fossil materials, a simpler and more ac

257 ut the role MMR pathway failure plays in the aging process of human HPCs.

258 A), in the dark ambient condition, while the aging process of MoS(2) with co-occurring ALHA was accel

259 ong impact of soot on global warming and the aging process of soot particles in the atmosphere, it is

260 ised tannins was sufficient to guarantee the aging process of sweet wines.

261 myelin abnormalities characterize the normal aging process of the brain and that an age-associated re

262 immune system over-activity may underlie the aging process of the human brain, and that potential ant

263 fection with CMV) in the acceleration of the aging process of the immune system, leading to 'immunose

264 tin antioxidant effects may slow the natural aging process of the lens.

265 and downregulation of mTORC1 could delay the aging process of the RPE.

266 dicals are among the most important chemical aging processes of organic aerosol particles in the atmo

267 Aging processes of secondary organic aerosol (SOA) may b

268 whether SCN1A modifies the vulnerability to aging processes of the human brain.

269 e studies concerning BDNF involvement in the aging processes of the teleost brain.

270 anges in HSCs may reflect the effects of the aging process on individual HSCs or a shift in the clona

271 ations in IMCL metabolism are related to the aging process per se.

272 iabetes may accelerate the underlying kidney aging process present in old mice.

273 or (mGluR) antagonists or lithium during the aging process prevented the onset of these deficits, and

274 rk structure of genes and miRNAs involved in aging processes promises to advance our understanding of

275 dal hormones in women combined with cellular aging processes promote sex biases in stress dysregulati

276 me) properties that remain stable during the aging process, rather than white matter microstructure t

277 Resilience and vascular pathways (aging process, sex differences, education/occupation, an

278 tochondrial dysfunctions associated with the aging process significantly modify nonlinear dynamical s

279 ious pathologies associated with the general aging process such as Alzheimer disease and the long-ter

280 diffusion processes in directed networks, or aging processes such as in fragmentation processes.

281 cells, are devoid of replicative associated aging processes, such as senescence and telomere shorten

282 mained constant in somatic tissues along the aging process, suggesting a lack of quality control mech

283 ases and highlights molecular markers of the aging process that might drive disease comorbidities.

284 lt-to-modify cultural and dietary habits and aging processes that are modifiable.

285 a visible, intuitive, top-down framework of aging processes that fosters knowledge-building and coll

286 components of the inflammatory process, the aging process, therapeutics, and drug or alcohol abuse.

287 The aging process therefore results in both a shift in the b

288 reverses cellular age, but alteration of the aging process through reprogramming has not been directl

289 h models are applicable to understanding the aging process throughout the 80-100 years of human life

290 he mechanisms by which DR interacts with the aging process to improve health in old age are poorly un

291 A panel of microRNAs (miRs) involved in aging processes was evaluated in cholangiocytes of young

292 ential role of alcohol use disorder (AUD) in aging processes, we employed Levine's epigenetic clock (

293 unctionalization reactions might be the main aging process were initiated by the cumulative effect of

294 discussed in terms of an expedited physical aging process, which is largely controlled by the hypera

295 otion that yellowing precedes tanning in the aging process, which is paralleled by fragmentation.

296 y increasing, an open visual encyclopedia of aging processes will be useful to both the new entrants

297 Complex interactions of the cardiovascular aging process with risk factors (obesity, hypertension,

298 tional to [Formula: see text] throughout the aging process, with minor deviations at the shortest tim

299 k by Li et al (2020) offers insight into the aging process within epithelial skin stem cells and high

300 s) provide a window into the neurobiology of aging processes within the brain and a potential biomark