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2 effect of these compounds on CB(1) receptor agonist-induced [(35)S]GTPgammaS binding, inhibition, an
6 rolongs the AP by 25% and abolishes the GPCR agonist-induced acceleration of the AP repolarization.
7 d for re-priming, had only a minor effect on agonist-induced accumulation of nonphosphorylated protei
8 we show that cSrc inhibition also blocks the agonist-induced acrosome reaction and that this inhibiti
9 increasing K(+) concentrations inhibited the agonist-induced acrosome reaction as well as the increas
10 cyte-derived dendritic cells (MoDCs) and TLR agonist-induced activation assessed by cytokine producti
12 lpha(IIb)beta(3) or P-selectin exposure upon agonist-induced activation in platelet-rich plasma or wh
15 depletion from the PM was achieved either by agonist-induced activation of phospholipase C beta or wi
16 n vitro, M8-B blocked cold-induced and TRPM8-agonist-induced activation of rat, human, and murine TRP
18 l assays, we identified residues involved in agonist-induced activation of TAS2R10, and investigated
19 effects of dopamine-2 receptor (D2R) and its agonist-induced activation on trafficking of Ca(V)2.2 is
22 rthermia-susceptible muscle, we investigated agonist-induced adenosine formation in lymphocytes as an
25 nd dynamin dependent and could be modeled as agonist-induced aggregation of transiently expressed GFP
27 pathway for ASMCs with respect to sustaining agonist-induced airway contraction and the underlying Ca
28 ay that mediates both swelling-activated and agonist-induced amino acid release in brain glial cells.
34 for 'self' are either eliminated through TCR-agonist-induced apoptosis (negative selection) or restra
35 ptor substates in favor of the active state, agonist-induced arrestin recruitment is accompanied by a
36 cells with ASM activated by IL-33 increased agonist-induced ASM contraction, and in vivo IL-33 induc
37 pathways mediating this Ca(2+) influx during agonist-induced ASMC contraction are not well defined.
38 hese studies show that photolysis but not by agonists induced astrocytic Ca(2+) signaling triggers gl
39 y IDO1 activity or treating mice with a GCN2 agonist induced autophagy and protected mice from nephri
42 th reduced beta-arrestin2 levels and delayed agonist-induced beta-arrestin2 recruitment to the membra
43 palmitoylation of Cys-265 is negligible, but agonist-induced beta2AR activation results in enhanced S
46 p38 Mapk activation but also plays a role in agonist-induced C-terminal and linker region phosphoryla
47 1 residues resulted in 58+/-3.8% decrease in agonist-induced C3aR phosphorylation there was no change
49 The decline in extracellular K(+) evoked by agonist-induced Ca(2+) in Bergmann glia transiently incr
54 the roles of CB2R agonist, GW405833 (GW) in agonist-induced Ca(2+) oscillations in pancreatic acinar
57 affect the ability of BH4-Bcl-2 to suppress agonist-induced Ca(2+) release in the cytosol or to prev
59 s also impaired, as indicated by reduced RyR agonist-induced calcium release from the ER and RyR-medi
60 hereas p11 overexpression potentiates mGluR5 agonist-induced calcium responses, overexpression of mGl
61 ceptor, the concentration-response curve for agonist-induced cAMP accumulation was shifted to the lef
62 ive allosteric modulation of the orthosteric agonist-induced cAMP accumulation, [(35)S]GTPgammaS bind
63 static beta2AR redox states are vital toward agonist-induced cAMP formation and subsequent CREB and G
67 vated ARC neurons was assessed by monitoring agonist-induced cellular activity via calcium imaging in
68 raft plasma membrane markers) to analyze the agonist-induced changes in compartmentalization of AT(1)
69 sensors serve the dual purpose of detecting agonist-induced changes in GPCR-G protein interactions,
70 ired-end tag sequencing of P300, we observed agonist-induced changes in long-range chromatin interact
71 that of the nAChR and GLIC, does not undergo agonist-induced channel gating, although it does not exh
74 ls, SOCE mediated by ORAI1 was necessary for agonist-induced chloride secretion and activation of the
75 intra- and interdimer cross-links such that agonist-induced closure of the LBD "clamshells" is trans
76 ion function-2 (AF-2) helix 12 mechanism for agonist-induced coactivator interaction and NR transcrip
77 h lacks the last 101 residues, revealed that agonist-induced confinement was abolished and that the a
78 ubject to various interpretations, including agonist-induced conformational change versus selective s
79 t GalphaiAGS3 and GalphaiAGS4 directly sense agonist-induced conformational changes in the receptor,
80 rings from Iqgap1-/- mice generated greater agonist-induced contractile force, even after removal of
81 ase, Ca(2+) influx, PKC and ROCK in alpha(1)-agonist-induced contraction and phosphorylation of key p
85 hetic TLR7 and TLR9 agonists, as well as TLR agonist-induced costimulatory molecule expression and TN
86 e (ACh): agonist sensitivity (EC50), maximal agonist-induced current (Imax), and time constant (tau)
89 n autologous plasma; levels of alum- and TLR agonist-induced cytokines and costimulatory molecules we
90 Imaging and preclinical studies have shown agonist-induced D2R internalization can be imaged with p
91 duced confinement was abolished and that the agonist-induced decrease in diffusivity was reduced subs
94 G protein-coupled receptor kinases (GRKs) in agonist-induced desensitization of the mu-opioid recepto
95 s lack the phosphorylation sites involved in agonist-induced desensitization of the other two subtype
96 nthol followed by its washout did not affect agonist-induced desensitization, suggesting that menthol
100 r of SL biosynthesis partially prevented CB2 agonist-induced effects on cell viability and motility.
102 essed as an intrabody, it robustly inhibited agonist-induced endocytosis of a broad set of GPCRs with
103 alendronate treatment functionally reversed agonist-induced endogenous beta2AR loss as indicated by
104 f proteins represent a major pathway for the agonist-induced entry of calcium associated with the gen
105 x metalloprotease inhibitor, GM6001, blocked agonist induced Erk activation within seconds, strongly
110 panded Treg cells with rapamycin and an RARA agonist induced expression of alpha4beta7 and had suppre
111 t Galpha(13), but not Galpha(q/11), controls agonist-induced expression of hypertrophy-specific genes
112 Intracerebroventricular injection of GPR17 agonists induced food intake, whereas administration of
113 sociated MOR-1Bs has been demonstrated in mu agonist-induced G protein coupling, adenylyl cyclase act
114 agonist binding nonetheless antagonized the agonist-induced G-protein coupling to the CB1 receptor,
116 erapeutic concentration, can antagonize hPXR agonist-induced gene expression and chemoresistance.
120 ction signal increases that occur later than agonist-induced GPCR/beta-arrestin interaction signals,
124 plays biased antagonism whereby it inhibits: agonist-induced guanosine 5'-O-(3-[(35)S]thio)triphospha
125 eater chromatin-GR binding with increased GR agonist-induced hAGT expression in liver and renal tissu
127 ngs may represent the first demonstration of agonist-induced heterodimerization of the H1R and H2R.
129 10 (PtdIns 4,5-P2-binding peptide) inhibited agonist-induced HLHCGR and cAMP accumulation but not ARF
130 tion in mouse or human platelets resulted in agonist-induced hyperactivation and increased calcium en
132 mice, as well as enhanced sensitivity to KOR agonist-induced hypolocomotion and analgesia-G protein s
133 rolactin response, but also blunted 5-HT(1A) agonist-induced hypothermia and increased 5-HT(2A) recep
134 from NT subjects led to a blunting of D(5) R agonist-induced increase in cAMP production and decrease
135 to internalize and bind GTP, blunting of the agonist-induced increase in cAMP production and decrease
136 m locus coeruleus neurons were made, and the agonist-induced increase in potassium conductance was me
137 e GIRK2 channel in Ts brain upon the GABAB R agonist-induced infantile spasms phenotype in the Ts mou
138 d GIRK2 channel is necessary for the GABAB R agonist-induced infantile spasms phenotype in the Ts mou
139 agonist tertiapin-Q also rescued the GABAB R agonist-induced infantile spasms phenotype in Ts mutants
143 elet adhesiveness is critically dependent on agonist-induced inside-out activation of heterodimeric i
144 so enhanced islet GLP1R expression and GLP1R agonist-induced insulin secretion and glucose tolerance.
146 thermore, CB1R(DeltaH9) is more sensitive to agonist-induced internalisation and less efficient at do
147 DP1 receptor (DP1) to the cell surface after agonist-induced internalization and that L-PGDS overexpr
148 ected by the three-residue mutation, with no agonist-induced internalization observed even in the pre
151 ells, we confirmed that AP-2 is required for agonist-induced internalization of endogenous PAR4.
152 face and facilitate resensitization, whereas agonist-induced internalization of PAR1 is critical for
158 nodine receptor (RyR), plays a major role in agonist-induced intracellular calcium ([Ca(2+)]cyt) dyna
163 (TG) hydrolysis, and its deficiency enhanced agonist-induced lipolysis in vivo CTRP2-deficient mice a
164 Cocaine-induced and quinpirole (D2 receptor agonist)-induced locomotion was enhanced in rats that co
165 LD not only failed to potentiate orthosteric agonist-induced LTD but also blocked M(1)-dependent LTD
166 estigated the role of cingulin in control of agonist-induced lung EC permeability via interaction wit
167 hat central administration of senktide (NK3R agonist) induced luteinizing hormone (LH) secretion in p
172 D5 receptors reversed priming, whereas D1/D5 agonists induced mechanical hypersensitivity exclusively
173 duce mGluR1 association with lipid rafts and agonist-induced, mGluR1-dependent activation of extracel
176 H4-Bcl-XL peptide via electroporation limits agonist-induced mitochondrial Ca(2+) uptake and protects
177 role for GRK2 (and potentially also GRK3) in agonist-induced MOPr desensitization in the LC, but leav
179 a Galphaibetagamma heterotrimer-biased CXCR4 agonist, induced more robust phosphorylation of Ser-346/
180 in NOP-eGFP and NOP-eYFP mice, NOP receptor agonists induced multisite phosphorylation and internali
181 ysiological mechanism acting in concert with agonist-induced MYPT1 phosphorylation to inhibit MLCP ac
182 Furthermore, cues associated with a KOR agonist-induced negative affective state were assessed f
183 H23390 administration into the OFC plus GABA agonist-induced neural inactivation of the contralateral
185 influx in skin and lung Arthus reactions and agonist-induced neutrophilia in the peritoneum, whereas
189 ntibodies to the NOP receptor, we found that agonist-induced NOP receptor phosphorylation occurred pr
190 sidue is selective for only GPCR but not RTK agonist-induced nuclear export and proteolytic degradati
191 ylation and COX-2 expression, whereas an EP4 agonist induced only transient increases in CREB phospho
193 d symptom remission after 2-3 months of GnRH agonist-induced ovarian suppression (leuprolide) then re
194 he effects of gonadotropin-releasing hormone agonist-induced ovarian suppression on mood, sleep, sexu
201 ociated protein stathmin in the mediation of agonist-induced permeability in EC cultures and vascular
203 rmeability transition pore (mPTP) formation, agonist-induced phosphatidylserine exposure and alphaIIb
204 Increased PAR1 expression also enhanced agonist-induced phosphoinositide hydrolysis and endothel
205 o and in vivo studies also revealed a 5-HT1A agonist induced phosphorylation of FGFR1 and extracellul
206 hly selective CK2 inhibitor, greatly reduced agonist-induced phosphorylation of beta-cell M3Rs, indic
207 hat receptor internalization is required for agonist-induced phosphorylation of extracellular signal-
210 r kinases 2 and 3 (GRK2/3) cooperated during agonist-induced phosphorylation, which, in turn, facilit
211 oss of negative signals from PKCalpha due to agonist-induced PKCalpha down-regulation and (b) positiv
213 The present study examines the impact of agonist-induced PKCbetaII activation on contractile func
216 ction of CIB1, and its ability to facilitate agonist-induced plasma membrane localisation of sphingos
219 n of IL-6 to the thrombocytosis, exaggerated agonist-induced platelet aggregation, and enhanced extra
223 tic potentiation induced by oxytocin, Avpr1b agonist-induced potentiation of CA2 synapses relies on N
226 3 showed robust efficacy in antagonizing KOR agonist-induced prolactin secretion and in tail-flick an
227 osphorylated PKCalpha is a direct target for agonist-induced proteasomal degradation via an Hsp-regul
231 r466 and Ser470 led to 40+/-1.3% decrease in agonist-induced receptor phosphorylation but this was as
232 ls stably expressing the M3-MR did not alter agonist-induced receptor phosphorylation or receptor int
233 work tested the hypothesis that lifetimes of agonist-induced receptor-arrestin clusters at the cell s
234 four residues to alanine partially decreased agonist-induced recruitment of arrestin3 without alterin
236 rthermore, overexpression of FBXO17 inhibits agonist-induced release of keratinocyte-derived cytokine
241 Structural characterization of the PAF-R agonists induced revealed multiple oxidized glycerophosp
243 has been implicated in the amplification of agonist-induced Rho signaling, leading to increased vasc
247 icient in syntaxin-11 had a robust defect in agonist-induced secretion although their morphology, act
250 binding but acted as an inhibitor of CB(1)R agonist induced signaling, including beta-arrestin2 tran
251 7 transmembrane biogenic amine receptors in agonist-induced signaling has not yet been clarified des
255 romatic residue at position VI:09, unchanged agonist-induced signaling was observed upon Ala substitu
256 s are required for the full dynamic range of agonist-induced signaling, as 5-HT(7) receptors spontane
259 stration of CL-316,243, a selective beta3-AR agonist, induced significant increases in non-rapid-eye
266 that low [Na(+)] is required to allow large agonist-induced structural changes in A2AR, and that pat
273 ntrast, sustained exposure (for 24 h) to all agonists induced tagged-5-HT(1A)R endocytosis in raphe s
278 induced traces, as well as the modulation of agonist-induced traces by anesthetic, either coapplied o
279 well, including both anesthetic-induced and agonist-induced traces, as well as the modulation of ago
280 Our results provide the first data on the agonist-induced trafficking of native GPR17 in oligodend
281 tty acid in synaptic membranes, enhances the agonist-induced transition to the desensitized state in
282 signaling to protein synthesis, deficits in agonist-induced translational control, protein synthesis
283 The TPR domain of AGS3 was required for agonist-induced translocation of AGS3 from the cell cort
288 antiviral responses and was critical for TLR agonist-induced, type 1 IFN-dependent suppression of inf
289 particle treatment prevented the cannabinoid agonist-induced up-regulation and enhanced 5-HT2A recept
290 identify the role of GRK5 in the cannabinoid agonist-induced up-regulation and enhanced activity of 5
291 Interestingly, we found that cannabinoid agonist-induced up-regulation of GRK5 involves CB2 recep
293 lephrine (100 mumol/L), an alpha1 adrenergic agonist, induced upregulation of Nox4 (1.5-fold; P<0.05)
294 in B cells is correlated with impaired TLR7 agonist-induced upregulation of activation markers CD69
295 owed that adenosine or an ADORA2A or ADORA2B agonist induced V-ATPase translocation from vesicles to
296 ed the time-of-day variations in response to agonist-induced vasoconstriction, myosin phosphorylation
297 e to troglitazone, a high-affinity PPARgamma agonist-induced vasorelaxation in UtA preconstricted wit