ライフサイエンスコーパス: agonistic

1 IL1RN by the C116F mutation did not make it agonistic.

2 imer with a 12-carbon linker was dual TLR7/8 agonistic.

3 orticoid-induced TNFR family-related protein agonistic Ab DTA-1 (rat or murinized IgG2a) can induce t

4 tudy, the functionality and potential of the agonistic Ab in the context of pathogenic aHUS-related F

5 ese findings suggest that the effect of 41BB agonistic Abs are supported by additional costimulatory

6 activation of 41BB costimulatory signals by agonistic Abs enhances the expansion and function of tum

7 costimulation and antitumor activity of CD27 agonistic Abs have been well documented in mouse models.

8 that the intratumoral administration of 41BB agonistic Abs led to increases in CD8 T cell infiltratio

9 efore, much effort has been made to generate agonistic Abs targeting members of the TNFR superfamily,

10 d costimulation by combining anti-PD-L1 with agonistic Abs to the TNFR superfamily members, OX40 and

11 everal weeks following T cell transfer, both agonistic Abs, but especially anti-CD27, demonstrated sy

12 the single-channel level, MBED mimicked the agonistic action of caffeine on cardiac RyR gating (i.e.

13 hether the disulfide linkage plays a role in agonistic action of IL-1beta.

14 ns reduced, but did not completely abrogate, agonistic action of IL-1beta.

15 a novel, alternate chemotype with pure TLR8-agonistic activities and will likely prove useful not on

16 vities of TNFR antibodies by enhancing their agonistic activities and/or effector functions.

17 Anti-Fn14 antibodies elicit agonistic activities differing from those of the natural

18 relation between the hypertensive and LPA(4) agonistic activities.

19 oavailable vasopressin antagonists devoid of agonistic activity (vaptans) has made possible the selec

20 expression program that generates RORgammat agonistic activity and promotes Th17 differentiation and

21 lay an alternative NFkappaB pathway-specific agonistic activity but fail to phenocopy other activitie

22 Agonistic activity can be transferred from h2 to h1 by s

23 Whereas CXCL10 displayed full agonistic activity for Galphai activation and extracellu

24 C108297 displays partial agonistic activity for the suppression of hypothalamic c

25 distinguish mutations that reduce or negate agonistic activity from those that maintained or increas

26 r kappa-opioid receptor affinity, full kappa agonistic activity in the [(35)S]GTPgammaS assay, and hi

27 induces the generation of a transient PAF-R agonistic activity in the blood of mice.

28 r oxidized glycerophosphocholines with PAF-R agonistic activity in this process.

29 ufexor (LMB763), a compound with partial FXR agonistic activity in vitro and FXR-dependent gene modul

30 Behavioral studies also support the biased agonistic activity of Colly in that it exhibits approxim

31 G2 and HeLa cells were used to determine the agonistic activity of EDCs on ERalpha and ERbeta via the

32 We examined the agonistic activity of EDCs through ERalpha and ERbeta.

33 1beta, but effectively reduced the remaining agonistic activity of the Lys mutants.

34 within primary human cancers or insufficient agonistic activity of the TRAIL-receptor (TRAIL-R)-targe

35 linkage by the F117C mutation did not affect agonistic activity of WT IL-1beta, but effectively reduc

36 els to validate our methods: beta-adrenergic agonistic activity on cAMP generation (dedicated dataset

37 de libraries derived from the ectodomain for agonistic activity on the receptors.

38 We observed a pure TLR8-agonistic activity profile in select furo[2,3-c]quinolin

39 1F5hIgG1, varlilumab, showed balanced agonistic activity that was prominent at lower doses and

40 human IgG2 (h2) imparts FcgammaR-independent agonistic activity to immune-stimulatory mAbs such as an

41 Surprisingly, a pronounced inverse agonistic activity was seen on the growth plate height,

42 consideration in clinical trials, showed no agonistic activity with respect to IL8 production and ce

43 The biased agonistic activity, along with an easily modifiable stru

44 y for the urotensin II receptor (UT) without agonistic activity, azasulfuryl-UII((4-11)) derivatives

45 singly, none of the test chemicals showed GR agonistic activity, but 12 chemicals exhibited apparent

46 betes drug, metformin, which carries an AMPK-agonistic activity, drastically inhibited the expression

47 azolyl)phenoxy]-2-propanol], which showed no agonistic activity, had only a marginal or no effect.

48 lacking ERalphaAF-2, resulting in no effect, agonistic activity, or inverse agonistic activity.

49 ), which is an IL-1beta homologue but has no agonistic activity.

50 in no effect, agonistic activity, or inverse agonistic activity.

51 required heparin, an HSPG analogue, for full agonistic activity.

52 ive) that possesses dual PPARgamma/PPARalpha agonistic activity.

53 with a carvedilol head group were devoid of agonistic activity.

54 ve TLR7 antagonists without any TLR7 or TLR8 agonistic activity.

55 pyl appendages at C5 displayed dominant TLR8-agonistic activity.

56 to evaluate the therapeutic potential of an agonistic agent for BTLA on CHS, the effects of an agoni

57 esults suggest that stimulation of BTLA with agonistic agents has therapeutic potential in CHS.

58 vation of the 4-1BB (CD137) pathway using an agonistic alpha-4-1BB antibody is known to provide stron

59 factor or FLT3 ligand) and costimulation by agonistic alpha-4-1BB or TLR 9 ligand, antibody-mediated

60 Treatment of mice with an agonistic alpha-EphA3 antibody inhibits tumor growth by

61 tion in vitro and in vivo, using GHRH or its agonistic analog MR-409.

62 The potential therapeutic effects of agonistic analogs of growth hormone-releasing hormone (G

63 the fatty acyl chains of LOS present in TLR4-agonistic and -antagonistic binary and ternary complexes

64 ine-derived compounds were screened for both agonistic and antagonistic activities against a panel of

65 Analysis of the agonistic and antagonistic activities of the resulting p

66 unds have been tested for their TLR7 or TLR8 agonistic and antagonistic activities.

67 biological complexity that is generated from agonistic and antagonistic Ang/Tie signaling.

68 nograft mice, the CC-trapping, GRPR-targeted agonistic and antagonistic constructs led to an approxim

69 Polychlorinated biphenyls (PCBs) had both agonistic and antagonistic effects on PPARG and GR, and

70 e calculated the binding affinity to MD-2 of agonistic and antagonistic LPS variants including lipid

71 fragment derivatives of TBPB identified both agonistic and antagonistic moieties, one of which, 1-(1-

72 e found that the pattern of co-activation of agonistic and antagonistic muscles changed based on whet

73 e incorporated these CC-trapping agents into agonistic and antagonistic pharmacophores targeting the

74 non and points to specific instances of both agonistic and antagonistic pleiotropy.

75 s and the peptide mimetics RF9 and BIBP3226, agonistic and antagonistic properties were characterized

76 The contextual agonistic and antagonistic Tie2 ligand ANGPT2 is believe

77 The requirement of FcR engagement for the agonistic and antitumor activities of 1F5 was demonstrat

78 Agonistic angiotensin II type 1 receptor autoantibodies

79 in biological processes or during ozonation, agonistic/antagonistic endocrine activities, mutagenic/g

80 Our findings suggest that adding an agonistic anti-4-1BB antibody during the time of TIL REP

81 However, addition of an exogenous agonistic anti-4-1BB IgG4 (BMS 663513) to the REP signif

82 g T cells and sensitizes resistant tumors to agonistic anti-4-1BB therapy.

83 e an inhibitory role of ecto-enzyme CD73 for agonistic anti-4-1BB/CD137 Ab therapy.

84 tic agent for BTLA on CHS, the effects of an agonistic anti-BTLA antibody (6A6) on CHS were examined.

85 ypothesized that treatment of aged mice with agonistic anti-CD137 (41BB) mAb will partially restore T

86 l line and cytokines was increased by adding agonistic anti-CD137 Abs to levels similar to CD137L-exp

87 nation therapy with PLX4720 and anti-CCL2 or agonistic anti-CD137 antibodies demonstrated significant

88 effects on persistent CHIKV infection of an agonistic anti-CD137 MAb that can activate T cell and na

89 Agonistic anti-CD137 monoclonal antibody (MAb) therapy h

90 echanistically distinct stimuli (ZOL, HMBPP, agonistic anti-CD277 mAb).

91 es in the nucleus following stimulation with agonistic anti-CD3 and anti-CD28 Abs, rendering them res

92 diated activation of human CD4(+) T cells by agonistic anti-CD3 mAb or by HLA class II-presented pept

93 Administration of agonistic anti-CD40 Ab to activate host APCs enhanced ac

94 odies and, together with previous reports on agonistic anti-CD40 antibodies, establish a common requi

95 er exposure to licensing stimuli, such as an agonistic anti-CD40 antibody or Toll-like receptor 3 lig

96 R-dependent activation of dendritic cells by agonistic anti-CD40 antibody was compromised in chronica

97 ment of autoimmunity and suggest that use of agonistic anti-CD40 for tumor therapy could result in au

98 This study shows that agonistic anti-CD40 induces strong and sustained prolife

99 We have previously shown the synergy of an agonistic anti-CD40 mAb (anti-CD40) and CpG-oligodeoxynu

100 CD40 was expressed on FRC and agonistic anti-CD40 mAb activated FRC, which supported C

101 In this article, we reveal that agonistic anti-CD40 mAbs have an absolute requirement fo

102 tope and isotype interact to deliver optimal agonistic anti-CD40 mAbs.

103 ater potency than previously reported highly agonistic anti-CD40 mAbs.

104 Here, we report that combining agonistic anti-CD40 monoclonal antibodies (mAb) to drive

105 ibodies and CSF-1R inhibition) or stimulate (agonistic anti-CD40 or inhibitory anti-CD47 antibodies)

106 We show that combination of agonistic anti-CD40 with antiangiogenic antibodies targe

107 ion development is accelerated in mice given agonistic anti-CD40.

108 nization with peptide Ags adjuvanted with an agonistic anti-CD40Ab, with or without the TLR3 ligand p

109 eport that activation of DR3 signaling by an agonistic anti-DR3 antibody increases GM-CSF production

110 Modulating Fas signaling using agonistic anti-Fas augmented TLR4- and TLR5-mediated TNF

111 We recently described an agonistic anti-FH mAb that can potentiate the regulatory

112 utic stimulation of GITR at this stage using agonistic anti-GITR Ab.

113 imulating monocytes from apoE(-/-) mice with agonistic anti-LTbR antibody or the natural ligand lymph

114 in were protected from the lethal effects of agonistic anti-mouse Fas antibody (Jo2) and had lower ra

115 ripheral blood eosinophils were treated with agonistic anti-Siglec-8 antibody and IL-5, and cell deat

116 sts increased TACI expression and whether an agonistic anti-TACI antibody could induce activation-ind

117 Agonistic anti-TNF receptor (TNFR) superfamily member an

118 omponents, we now demonstrate that different agonistic anti-TNFR antibodies have specific requirement

119 engagement for optimal biological effects of agonistic anti-TNFR antibodies.

120 informed the design of more potent antitumor agonistic, anti-TNFR therapies, the underlying mechanism

121 radiotherapy, we found CD40 activation with agonistic antibodies (aCD40) produced complete tumor reg

122 resent an effective strategy for discovering agonistic antibodies against other enzyme targets.

123 elated apoptosis-inducing ligand (TRAIL) and agonistic antibodies against TRAIL death receptors (DR)

124 Recombinant soluble TRAIL and agonistic antibodies against TRAIL receptors (DR4 and DR

125 Agonistic antibodies are powerful tools to dimerize rece

126 Agonistic antibodies directed against immunostimulatory

127 ive NK cells through NKG2C using plate-bound agonistic antibodies in combination with IL-15 drove rob

128 Crosslinking CD28 by agonistic antibodies or myeloid dendritic cells (DC; the

129 as a target for therapeutic strategies with agonistic antibodies or using its cognate cytokine ligan

130 d angiopoietin-2 (ANGPT2) combined with CD40 agonistic antibodies promoted antiangiogenic and immunos

131 re rarely developed because the discovery of agonistic antibodies remains elusive.

132 SF receptor(s) cross-linking by CD40 and Fas agonistic antibodies resulted in dose-limiting liver tox

133 However, agonistic antibodies that enhance the activities of the

134 In particular, agonistic antibodies that target tumor necrosis factor r

135 alter the viability of human neutrophils via agonistic antibodies to Fas and Siglec-9.

136 Thus, agonistic antibodies to the receptor have been used for

137 One of the resultant agonistic antibodies, 27C3, binds to and substantially e

138 iNPs), each containing multiple copies of an agonistic antibody (FGK45) to the APC receptor CD40, gre

139 nd downstream signaling mediated by TLR4/MD2 agonistic antibody (UT12) and synthetic small-molecule T

140 ancer cell lines highly sensitive to the DR5 agonistic antibody AMG655 have either Ras or B-Raf mutat

141 optotic response induced by TRAIL or the DR5 agonistic antibody AMG655 or cell killing by activated T

142 poptosis when combined with TRAIL or the DR5 agonistic antibody AMG655; these effects are DR5-depende

143 in antitumor immunity generated by the GITR agonistic antibody DTA-1.

144 ng the co-stimulatory receptor CD137 with an agonistic antibody enhanced CD4+ T cell cytotoxicity.

145 We developed an agonistic antibody modality, termed antibody ligand mime

146 growth factor receptor (HGFR/c-MET) with an agonistic antibody resulted in distinct cBLI signal patt

147 rtal of entry of hepatitis C virus (HCV)] by agonistic antibody results in phosphorylation of Ezrin v

148 Triggering TACI by an agonistic antibody showed loss of activation-induced cyt

149 In contrast, an anti-GITR agonistic antibody significantly alleviated colitis in R

150 g antigen-specific adoptive T-cell transfer, agonistic antibody therapy (anti-CD137/4-1BB), and check

151 property of SA-4-1BBL, as treatment with an agonistic antibody to the 4-1BB receptor was ineffective

152 B cells to Fas ligand (FasL)-induced and Fas agonistic antibody-induced apoptosis through enhanced bi

153 age-related changes can be rescued by a TIE2 agonistic antibody.

154 to apoptosis by extracellular PAR-4 or GRP78 agonistic antibody.

155 NK cells in naive mice as compared with the agonistic antibody.

156 peripheral T cells poised for responding to agonistic antigen-driven T cell activation.

157 at the C4, C8, and N(1)-aryl positions were agonistic at TLR7; only the N(1)-aryl dimer with a 12-ca

158 AT(1) agonistic autoantibodies are also highly abundant among

159 examples extend the clinical impact of AT(1) agonistic autoantibodies beyond pregnancy.

160 These autoantibodies, termed AT(1) agonistic autoantibodies have been extensively character

161 However, the occurrence of AT(1) agonistic autoantibodies is not restricted to pregnancy.

162 a in an angiotensin receptor type 1 receptor agonistic autoantibody (AT(1) -AA)-induced mouse model o

163 Noting that cells responding to low pO2 or agonistic bacterial molecules often decrease pHo by secr

164 sniffing frequency shortened the latency for agonistic behavior by dominant rats, reflecting that dec

165 unction and supports previously hypothesized agonistic behavior in pachycephalosaurids.

166 havior between cage-mates, and low levels of agonistic behavior in the home-cage.

167 The biological data, highlighting the potent agonistic behavior of [Tiq(4)]URP and [Tpi(4)]URP, also

168 In contrast to the weak agonistic behavior of aripiprazole, these ligands are ca

169 Some, such as eusocial insects, may use agonistic behavior to partition available foraging habit

170 activity in several brain regions governing agonistic behavior to territorial song production in fem

171 c expression of a neuropeptide that controls agonistic behaviors across phylogeny.

172 ith established social hierarchies abolished agonistic behaviors and reciprocal sniffing displays.

173 ion causes a range of deficits in sexual and agonistic behaviors that normally rely on the posterior

174 sing of social stimuli and the expression of agonistic behaviors.

175 hat the winner-loser effect on initiation of agonistic behaviour (display, non-damaging aggression, b

176 ng data, relative testes mass, and male-male agonistic behaviour between two species of hissing cockr

177 Agonistic behaviour, up to reciprocal fighting, in conte

178 aggressiveness in determining initiation of agonistic behaviour.

179 vity is continuously required during ongoing agonistic behaviour.

180 nding pocket of hPXR plays a key role in the agonistic binding of PB and mutation of tryptophan-299 d

181 potential to promote type 1 immunity through agonistic binding to neurokinin-1 receptor (NK1R).

182 this variant revealed both antagonistic and agonistic canonical WNT stimuli, dependent on cell type.

183 resting MDS-NK cells were triggered with an agonistic CD16 monoclonal antibody.

184 hese results demonstrate that control of non-agonistic CD1d-associated lipids is critical for iNKT ce

185 w that stimulation of naive CD8 T cells with agonistic CD3 and CD28 Abs, mimicking TCR and costimulat

186 Supporting this result, agonistic CD40 antibody was sufficient to evoke antitumo

187 wed by a composite vaccination, including an agonistic CD40 antibody, soluble antigen, and a TLR3 ago

188 Agonistic CD40 mAb promotes stromal degradation and, in

189 his hypothesis was recently formalised in an agonistic character displacement (ACD) model which predi

190 placement, RCD) or interspecific aggression (agonistic character displacement, ACD).

191 IL-6 trans-signaling, in which IL-6 forms an agonistic complex with the soluble IL-6 receptor (sIL-6R

192 s and serum-starved, followed by exposure to agonistic compounds targeting various receptors, while r

193 r shape of its carbohydrate backbone in the "agonistic" conformation attained by a rigid alphaGlcN(1<

194 In contrast, success of agonistic costimulatory antibodies has thus far been lim

195 Thus, booster vaccinations with agonistic costimulatory antibodies represent an ideal me

196 rane-bound IL-6 alpha-receptor (IL-6R) as an agonistic cytokine but also as a gp130 beta-receptor ant

197 r, we demonstrate that murine p28 acts as an agonistic cytokine via the murine and human IL-6R, indic

198 dynamics, and tumor retention kinetics of an agonistic DR5 antibody in a brain tumor xenograft model,

199 was an even distribution of antagonistic and agonistic effect directions among the shared loci, in li

200 cts robustly with the TrkB receptor, and its agonistic effect may be mediated by neuronal development

201 nding site of the human P2X3 receptor on the agonistic effect of nucleotide analogs.

202 Furthermore, the specific agonistic effect of the estrogen receptor activation cou

203 tetrabromobisphenol A, and PCB170 had a weak agonistic effect on pbPPARG, while hexabromocyclododecan

204 d inhibited activation, partially due to its agonistic effect.

205 due to stimulation of MnSOD activity through agonistic effects at mitochondrial ERbeta.

206 Here we demonstrate the agonistic effects of three PKA-selective cAMP derivative

207 In contrast, it lacks agonistic effects on the expression of CRH in the centra

208 s exhibit chirality-specific antagonistic or agonistic effects.

209 st (R)-(+)-Bay K8644, and a titration of its agonistic enantiomer (S)-(-)-Bay K8644 at resolutions of

210 Agonistic encounters are powerful effectors of future be

211 ences in social status are often mediated by agonistic encounters between competitors.

212 ounding patterns, territorial behaviour, and agonistic encounters of a wild population of Javan slow

213 othesise that individuals need experience of agonistic encounters to become proficient at mutual asse

214 ing intraspecific competition while avoiding agonistic encounters with whitespotted charr.

215 s induced by winning and losing bouts during agonistic encounters.

216 nse to viewing the positive anticipation and agonistic facial expressions.

217 Angiopoietin 1 (Ang-1) is agonistic for Tie2, plays a key role in blood vessel mat

218 tial for resolving the paradoxes among their agonistic function, antidiabetic activities, and side ef

219 more potent and selective inhibitors without agonistic function.

220 uding antagonistic monoclonal antibodies and agonistic fusion proteins to inhibit or potentiate these

221 8(+) T-cell exhaustion was dependent on both agonistic GITR signaling and Treg depletion, as neither

222 27C3 and other agonistic human anti-human LCAT monoclonal antibodies de

223 n of FcmuR and Fas/CD95 on Jurkat cells with agonistic IgM anti-Fas mAb was shown to inhibit Fas-indu

224 beta to integrins is primarily important for agonistic IL-1beta signaling, and that the disulfide lin

225 sufficient structural similarity with TLR7/8-agonistic imidazoquinolines.

226 upon subimmunogenic vaccination with strong agonistic insulin mimetopes in vivo.

227 at Drosophila exchange information during an agonistic interaction and choose appropriate actions bas

228 o the stressful event of being exposed to an agonistic interaction between conspecifics housed in the

229 at the difference can be seen soon after the agonistic interaction establishing winners and losers.

230 urs were quantified before, during and after agonistic interaction exposure, based on video recording

231 Displacement behaviours increased after agonistic interaction exposure, confirming that the even

232 Agonistic interactions (n = 761) among 71 Dolly Varden S

233 ocument the systematic use of signals during agonistic interactions among octopuses.

234 corded air-breathing behaviour, activity and agonistic interactions at varying levels of hypoxia.

235 rther, males show a relative shift from more agonistic interactions to more positive, affiliative int

236 Agonistic interactions were relatively rare and were res

237 re we report that, when mason bees engage in agonistic interactions, a species-typical interactive be

238 ange of visible displays are produced during agonistic interactions, and these displays correlate wit

239 nous air-breathing is strongly influenced by agonistic interactions, which may expose subordinate ind

240 e context of strategic action choices during agonistic interactions.

241 pacing did not increase during or after the agonistic interactions.

242 ad, agitated locomotion increased during the agonistic interactions.

243 Although rare, several taxa use venom for agonistic intraspecific competition (e.g. ghost shrimp,

244 orylation mapping of HER2 indicated that the agonistic isomers produced a distinct phosphorylation pa

245 a a, thus, far only partially known Tethered Agonistic LIgand (TALI).

246 Determinants required for agonistic ligand activity were identified.

247 GabR support the conclusion that AFPA is an agonistic ligand capable of triggering GabR-mediated tra

248 The agonistic ligand CITCO binds directly to the CAR homodim

249 Thus-generated molecules constitute agonistic ligands for the first and second binding pocke

250 Furthermore, activation of CD137 with an agonistic mAb enhanced NK cell degranulation and cytotox

251 previously that single injection of a PD-1H agonistic mAb protected mice from graft-versus-host dise

252 mbinant human TRAIL and drozitumab (anti-DR5 agonistic mAb) were used to explicitly verify the contri

253 e examined the impact of an anti-human TREM2 agonistic mAb, AL002c, in a mouse AD model expressing ei

254 Elevating cAMP signaling either by the agonistic MC1R ligand melanocyte stimulating hormone (MS

255 efore be a selective glucocorticoid receptor agonistic modulator (SEGRAM).

256 ompounds are bona fide selective GC receptor agonistic modulators (SEGRAMs) as none of the known GC-i

257 Agonistic monoclonal antibodies (mAb) targeting the T-ce

258 Agonistic monoclonal antibodies targeting 4-1BB have bee

259 whereas neither of these IVIG fragments, nor agonistic monoclonal antibodies to human Fas or Siglec-9

260 a-related apoptosis inducing ligand (TRAIL), agonistic monoclonal antibodies to TRAIL receptors, and

261 SLAMF1 ligation with an agonistic monoclonal antibody increased ROS accumulation

262 equirement for in vivo antitumor activity of agonistic mouse anti-CD40 monoclonal antibodies (mAbs),

263 he development of a panel of anti-human OX40 agonistic mouse mAbs that could promote effector CD4(+)

264 d expressed a protein complex containing the agonistic natural killer (NK) receptor NKG2D and the NK

265 human exposure warrants further studies into agonistic or antagonistic activities and their potential

266 dividual congeners (2 fM to 2 muM) exhibited agonistic or antagonistic activity in a THR reporter cel

267 ose-related effects that differ depending on agonistic or antagonistic drug characteristics and on lo

268 ptor more effectively to produce an enhanced agonistic or antagonistic effect.

269 ietin-2 (ANGPT2) is a context-dependent TIE2 agonistic or antagonistic ligand that induces diverse re

270 nd absence of erythropoietin and a series of agonistic or antagonistic mimetic peptides free in solut

271 a combination of stress factors may require agonistic or antagonistic responses or responses potenti

272 However, in contrast to conventional FPR2 agonistic peptides, including the host-derived formyl pe

273 Similar to many other FPR2 agonistic peptides, nanomolar concentrations of both PSM

274 We identify genes that exhibit agonistic pleiotropy for genetically correlated traits t

275 horse but that the PR evolved with increased agonistic potency for DHP at the expense of potency towa

276 els of such conditions exceed its known PPAR agonistic profile.

277 The ligands' agonistic properties are substantially driven by the pre

278 antagonistic properties at alpha1GABAARs and agonistic properties at the other three benzodiazepine-s

279 ne], pindolol, and timolol, which displayed agonistic properties toward the beta(1)AR in either the

280 While weak inverse agonistic properties were determined for the biphenyl ca

281 kynurenine, a tryptophan metabolite with AhR agonistic properties, is an endogenous ligand that media

282 ing, however, as bivalent antibodies exhibit agonistic properties, whereas monovalent antibodies lack

283 d TNFR family-related protein-induced T cell agonistic properties.

284 ting that this class of compounds could have agonistic properties.

285 nerates homogenous h2 variants with distinct agonistic properties.

286 ifferent mechanisms, direct tumor targeting, agonistic receptor engagement, or receptor-ligand blocka

287 We described a detailed SAR in TLR2 agonistic scaffolds and also covered the design and chem

288 )-1H-benzo[d]imidazol-2(3H)-1 (VCP794), lost agonistic selectivity for the M(1) mAChR.

289 ein-coupled receptor (aGPCR) family carry an agonistic sequence within their large ectodomains.

290 ty of our results to an influential model of agonistic signaling [13].

291 binding, mechanical force, and the tethered agonistic Stachel sequence, as well as implications on t

292 LPS stimulation is reversed with alpha7nAChR agonistic stimulation.

293 AMG655 to introduce a highly active TRAIL-R2-agonistic therapy into the cancer clinic.

294 antagonistic antibody, and EHD2-scTNFR2, an agonistic TNFR2-selective TNF, respectively, in a mouse

295 f DR3 as an ILC2 regulator and introduce DR3 agonistic treatment as a novel therapeutic avenue for tr

296 ese results highlight the importance of PD-1 agonistic treatment in allergic asthma and underscore it

297 racellular domain of TREM-1 (rTREM-1) and an agonistic TREM-1 antibody were used to inhibit and activ

298 Using an agonistic tumor necrosis factor-receptor super family (T

299 Treatments with either an agonistic VD3 analog or RA dissociate the repressing com

300 Agonistic VISTA engagement increased T cell tolerance by