ライフサイエンスコーパス: airflow obstruction

1 ch share a common complication of reversible airflow obstruction.

2 io are considered the standard assessment of airflow obstruction.

3 ol, and apoB are associated with more severe airflow obstruction.

4 richment analysis to a meta-analyzed GWAS of airflow obstruction.

5 the presence of comorbidities compared with airflow obstruction.

6 the lungs that leads to progressive chronic airflow obstruction.

7 d with abnormal immune responses, leading to airflow obstruction.

8 erapy in 5,887 smokers with mild to moderate airflow obstruction.

9 der characterized by incompletely reversible airflow obstruction.

10 r (3) maldistribution of inspired gases with airflow obstruction.

11 ding onto the development and persistence of airflow obstruction.

12 d implicate the HTR4 gene in the etiology of airflow obstruction.

13 scular inflammation and largely irreversible airflow obstruction.

14 compartments correlated with the severity of airflow obstruction.

15 xacerbations, independent of the severity of airflow obstruction.

16 l as mucus hypersecretion, which can lead to airflow obstruction.

17 vital capacity (FEV(1)/FVC), an indicator of airflow obstruction.

18 , spirometry should be performed to diagnose airflow obstruction.

19 re most evident in patients with more severe airflow obstruction.

20 ikely amplifies inflammation and progressive airflow obstruction.

21 d biosynthesis correlated with the degree of airflow obstruction.

22 lead to bronchial lymphedema and exaggerated airflow obstruction.

23 ated with exposure intensity, independent of airflow obstruction.

24 re asthma, likely contribute to irreversible airflow obstruction.

25 well as mucus hypersecretion with subsequent airflow obstruction.

26 ure intensity, independent of ex-smoking and airflow obstruction.

27 derate airflow obstruction and 2.61 for mild airflow obstruction.

28 group may disclose novel mechanisms of fixed airflow obstruction.

29 n and did not correlate with the severity of airflow obstruction.

30 rment of the diffusion capacity (DL(CO)) and airflow obstruction.

31 n is not a major risk factor for progressive airflow obstruction.

32 /- 15 yr (mean +/- SD) with fixed expiratory airflow obstruction.

33 guish between infants with and those without airflow obstruction.

34 arly evident in patients with severe chronic airflow obstruction.

35 a risk factor for the development of chronic airflow obstruction.

36 way remodeling seen in patients with chronic airflow obstruction.

37 ce by 2 weeks of age and was associated with airflow obstruction.

38 ased risk of developing chronic irreversible airflow obstruction.

39 NO2 levels can be associated with increased airflow obstruction.

40 y, cell adhesion, epigenetic regulation, and airflow obstruction.

41 PRM(FSA) and age in subjects with or without airflow obstruction.

42 asthma with a history of smoking and chronic airflow obstruction.

43 ts with mild to moderate post-bronchodilator airflow obstruction.

44 sistent respiratory symptoms and progressive airflow obstruction.

45 iation contributing to emphysema with severe airflow obstruction.

46 stratified by asthma symptom control and by airflow obstruction.

47 ncreased in both groups with the severity of airflow obstruction.

48 with increased cough, sputum production, and airflow obstruction.

49 links between asthma and subsequent chronic airflow obstruction.

50 racts with SZ-AATD to significantly increase airflow obstruction.

51 co smoking are risk factors for irreversible airflow obstruction.

52 a have additive or multiplicative effects on airflow obstruction.

53 r human study subjects developed significant airflow obstruction 10 min postexposure which persisted

54 Undiagnosed airflow obstruction (12.0%) was more common than doctor-

55 However, among females with airflow obstruction, 12.2% to 35.2% never smoked.

56 COPD (198 [4%] of 4439) and smokers without airflow obstruction (255 [5%] of 5547).

57 To examine sex differences in the risk of airflow obstruction (a COPD hallmark) in relation to smo

58 Perform meta-analyses of GWAS for airflow obstruction, a key pathophysiologic characterist

59 nchodilators was associated with more severe airflow obstruction, a predominantly solid pattern of LA

60 ntial shared genetic architecture underlying airflow obstruction across individuals, irrespective of

61 In subjects without airflow obstruction, acute respiratory events were not a

62 acute respiratory events in smokers without airflow obstruction affect lung function decline is unkn

63 ogeneic hematopoietic stem cell transplants, airflow obstruction (AFO) remains a significant complica

64 s that may be involved in the development of airflow obstruction after hematopoietic cell transplanta

65 that could be related to symptom control and airflow obstruction after standardized treatment.

66 In never- and ever-smokers without airflow obstruction, aging is associated with increased

67 etric abnormalities, and was correlated with airflow obstruction, air trapping, and diffusing capacit

68 COPD is defined by irreversible airflow obstruction; airflow obstruction is typically de

69 isease of the lung characterized by variable airflow obstruction, airway hyperresponsiveness (AHR), a

70 common chronic lung disease characterized by airflow obstruction, airway hyperresponsiveness (AHR), a

71 Asthma is characterized by variable airflow obstruction, airway inflammation, airway hyper-r

72 vel of CerS2 was associated with significant airflow obstruction, airway inflammation, and increased

73 irways hyperresponsiveness (AHR), reversible airflow obstruction, airway remodeling, and episodic exa

74 arette smoking correlated more strongly with airflow obstruction among PI*SZ than PI*ZZ subjects.

75 ted a maximum LOD score of 2.09 for moderate airflow obstruction and 2.61 for mild airflow obstructio

76 ase refers to a group of diseases that cause airflow obstruction and a constellation of symptoms, inc

77 but not total IgE, is associated with fixed airflow obstruction and a number of radiological abnorma

78 Our findings suggest that early airflow obstruction and air trapping in infants with cys

79 se characterized by intermittent, reversible airflow obstruction and airway hyperresponsiveness (AHR)

80 a is heightened and related to the degree of airflow obstruction and airway hyperresponsiveness.

81 s are chronic lung diseases characterized by airflow obstruction and airway inflammation.

82 nses were then compared with measurements of airflow obstruction and airway responsiveness.

83 8 (LOD = 1.36) and 19 (LOD = 1.09) for mild airflow obstruction and chromosomes 19 (LOD = 1.21) and

84 vided increased evidence for linkage of mild airflow obstruction and chronic bronchitis to several ge

85 tives of these early-onset COPD probands for airflow obstruction and chronic bronchitis was performed

86 t PiMZ heterozygotes have significantly more airflow obstruction and COPD than PiMM individuals and c

87 control subjects and influenced by worsening airflow obstruction and corticosteroid use.

88 al dysfunction, which results in progressive airflow obstruction and debility.

89 apoA-I and large HDLNMR particles can reduce airflow obstruction and disease severity in asthma.

90 iated with a significantly increased risk of airflow obstruction and emphysema but the risk of chroni

91 medium-dose inhaled corticosteroids reduces airflow obstruction and improves asthma control in patie

92 human deoxyribonuclease 1 (rhDNase) reduces airflow obstruction and improves mucociliary clearance i

93 racterize the kinetics of grain dust-induced airflow obstruction and inflammation in the lower respir

94 begins in infancy or childhood with variable airflow obstruction and intermittent wheezing, cough, an

95 response (BDR) reflects the reversibility of airflow obstruction and is recommended as an adjunctive

96 Both groups developed significant airflow obstruction and lower airway inflammation after

97 ingle inhalation challenge of CDE results in airflow obstruction and lower respiratory tract inflamma

98 e (COPD) is characterized by the presence of airflow obstruction and lung destruction with airspace e

99 early-onset nonsevere asthma and reversible airflow obstruction and normal airway structure.

100 ized clinically by older age and more severe airflow obstruction and pathologically by a second T2 ne

101 ung function are at increased risk for fixed airflow obstruction and possibly COPD in early adulthood

102 constrict airway smooth muscle, but elicits airflow obstruction and pulmonary inflammation in patien

103 mmunological biomarkers are related to fixed airflow obstruction and radiological abnormalities in mo

104 Fixed airflow obstruction and radiological abnormalities were

105 Understanding the genetic basis of airflow obstruction and smoking behaviour is key to dete

106 ve effects of etoricoxib on allergen-induced airflow obstruction and sputum eosinophils, basal lung f

107 In adults, differences in airflow obstruction and symptoms between SA and NONSA pe

108 inophilic airway inflammation contributes to airflow obstruction and symptoms in some patients with C

109 Preliminary studies have shown that both airflow obstruction and systemic inflammation may contri

110 positively with the severity of inflammatory airflow obstruction and the level of methacholine airway

111 nd to lesser extent of Twist, was related to airflow obstruction and to expression of a canonical EMT

112 m the association between skin wrinkling and airflow obstruction and to identify genetic polymorphism

113 particular showed a direct correlation with airflow obstruction and treatment requirement in patient

114 We found no association between airflow obstruction and use of solid fuels for cooking o

115 pulmonary disease, who had at least moderate airflow obstruction and were taking part in PR, were ran

116 e that included IL-6 (in cases of mild or no airflow obstruction), and one that included BMP1 (in cas

117 nstrated reduced diffusing capacity; 20% had airflow obstruction, and 20% had chest restriction.

118 and 80% had late-onset asthma, 50% had fixed airflow obstruction, and 66% showed a Th2-high phenotype

119 The presence of air trapping, airflow obstruction, and airway size reduction in newbor

120 yper-responsiveness, incompletely reversible airflow obstruction, and asthma-related school and work

121 al-appearing lung regions in smokers without airflow obstruction, and it is associated with respirato

122 smooth muscle bronchoconstriction leading to airflow obstruction, and mucous hypersecretion are clini

123 ously that lower respiratory tract symptoms, airflow obstruction, and neutrophilic airway inflammatio

124 d in lungs of never smokers, smokers without airflow obstruction, and patients with COPD by reverse t

125 ovel candidate gene in emphysema with severe airflow obstruction, and rs61754411 is a previously unre

126 ilic inflammation, the attributes of chronic airflow obstruction, and the notion of corticosteroid in

127 cific incidence trends of pre-bronchodilator airflow obstruction (AO) among adults without asthma fro

128 Air trapping and airflow obstruction are being increasingly identified in

129 as detected on computed tomography (CT), and airflow obstruction are inversely related to left ventri

130 Defining airflow obstruction as FEV1:FVC less than 0.70 provided

131 se findings help to explain heterogeneity of airflow obstruction as well as why, in people with asthm

132 Airflow obstruction assessed from post-bronchodilator sp

133 a lung disorder characterized by progressive airflow obstruction associated with inflammation and emp

134 eling and contributes to the mucus plugs and airflow obstruction associated with severe asthma phenot

135 acute exacerbation (AE) in patients without airflow obstruction (Asthma AE group).

136 osing COPD in patients with mild to moderate airflow obstruction at baseline.

137 rsible airflow obstruction, in some patients airflow obstruction becomes irreversible.

138 Smokers with airflow obstruction benefit from quitting despite previo

139 is similar to cluster T2 in terms of chronic airflow obstruction but is composed of nonsmokers.

140 before age 18 years were more likely to have airflow obstruction, but a sex difference in this associ

141 tio Impaired Spirometry (PRISm) will develop airflow obstruction, but there are no established method

142 ve or multiplicative effects on the risk for airflow obstruction, but this has not been demonstrated

143 us by goblet cells, which leads to worsening airflow obstruction by luminal obstruction of small airw

144 d-onset persistent asthma is associated with airflow obstruction by mid-adult life, but this does not

145 for INtrinsic and EXtrinsic skin Aging) and airflow obstruction by spirometry, using the ratio of fo

146 essure support ventilation in the setting of airflow obstruction can be accompanied by marked variati

147 revalence of the broader category of chronic airflow obstruction (CAO), defined as asthma, chronic br

148 tation (SLT) is widely used to treat chronic airflow obstruction (CAO).

149 on, airway hyperresponsiveness, and variable airflow obstruction cause cough are unclear.

150 Asthma is a disease of reversible airflow obstruction characterised clinically by wheezing

151 LOD = 1.70) and 19 (LOD = 1.54) for moderate airflow obstruction, chromosomes 8 (LOD = 1.36) and 19 (

152 d one that included BMP1 (in cases of severe airflow obstruction).Conclusions: Two distinct stromal g

153 atopoietic stem cell transplantation-related airflow obstruction, consensus diagnostic criteria, and

154 ight into the specific mechanisms underlying airflow obstruction, COPD, and tobacco addiction, and sh

155 ontrol, recurrent exacerbations, and chronic airflow obstruction despite adequate and, in many cases,

156 a have frequent exacerbations and persistent airflow obstruction despite treatment with inhaled gluco

157 ng was strongly associated with all types of airflow obstruction, diagnosed or not.

158 roduction in asthma is an important cause of airflow obstruction during severe exacerbations.

159 to -13.2]; p=0.006), higher Body Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity (BOD

160 total score (SGRQ), and the body mass index, airflow obstruction, dyspnea, and exercise capacity (BOD

161 to -8.556; P < 0.001), and body mass index, airflow obstruction, dyspnea, and exercise capacity inde

162 ore, -0.6 points; and BODE (body mass index, airflow obstruction, dyspnea, and exercise capacity) ind

163 OPD assessment test scores, Body-mass index, airflow Obstruction, Dyspnea, and Exercise index, or Glo

164 cted, 37 [29-45]; and BODE [body mass index, airflow obstruction, dyspnea, and exercise] index, 6 [5-

165 The BODE index (including body-mass index, airflow obstruction, dyspnoea, and exercise capacity) wa

166 ecreased lung function and increased odds of airflow obstruction, even in participants who had never

167 esent in symptomatic infants with reversible airflow obstruction, even in the presence of atopy.

168 c airway disease characterized by paroxysmal airflow obstruction evoked by irritative stimuli on a ba

169 Patients with moderate chronic airflow obstruction experienced a reduction in exacerbat

170 predicted, FEV(1)/FVC < 90% predicted], mild airflow obstruction (FEV(1) < 80% predicted, FEV(1)/FVC

171 ion, the patients with LDA continued to show airflow obstruction (FEV(1)% predicted = 65.4 +/- 2.9).

172 ed physical activity (multisensory armband), airflow obstruction (FEV1), health status (St. George's

173 Moderate/severe airflow obstruction (FEV1/forced vital capacity <0.70 an

174 health and functional impact of undiagnosed airflow obstruction for subjects in the general populati

175 f lung for carbon monoxide (Dlco%) than with airflow obstruction (forced expiratory volume in 1 secon

176 or qualitative phenotypes including moderate airflow obstruction [forced expiratory volume at one sec

177 cts with asthma who smoke or who have severe airflow obstruction from linkage analysis, as well as in

178 fied ADO index (including age, dyspnoea, and airflow obstruction) from the Swiss cohort, and validate

179 Asthmatics with persistent airflow obstruction had greater airway smooth muscle (As

180 A proportion of 26.3% of smokers without airflow obstruction had ND-E/I greater than the 90th per

181 f of the estimated 24 million Americans with airflow obstruction have received a COPD diagnosis, and

182 tantial proportion of subjects without overt airflow obstruction have significant respiratory morbidi

183 morbidity, more severe BDR and BHR, greatest airflow obstruction, high smoking prevalence, higher sym

184 acity (FVC) ratio is used as a criterion for airflow obstruction; however, the test characteristics o

185 isease characterized, in part, by reversible airflow obstruction, hyperresponsiveness and inflammatio

186 Cluster analysis of adults with symptomatic airflow obstruction identifies 5 disease phenotypes, inc

187 nd significantly correlated with measures of airflow obstruction in asthma patients.

188 tly responsible for the development of fixed airflow obstruction in asthma.

189 f the gut-lung axis can be targeted to treat airflow obstruction in asthma.

190 Spirometry should not be used to screen for airflow obstruction in asymptomatic individuals.

191 all conducting airways are the major site of airflow obstruction in chronic obstructive pulmonary dis

192 y therapy caused significant improvements in airflow obstruction in eosinophilic asthma, but not in p

193 fferences in gene expression were related to airflow obstruction in epithelial cells (C3, ALOX5AP, CC

194 Spirometry should not be used to screen for airflow obstruction in individuals without respiratory s

195 be a marker of neutrophilic inflammation and airflow obstruction in patients with asthma, who have a

196 ar-capillary membrane function and increases airflow obstruction in patients with LVD but not in norm

197 We conclude that airflow obstruction in patients with OSA causes an acute

198 at spirometry should be obtained to diagnose airflow obstruction in patients with respiratory symptom

199 hyperreactivity (AHR, defined by exaggerated airflow obstruction in response to bronchoconstrictors),

200 ated in relation to both symptom control and airflow obstruction in severe asthmatics.

201 nchitis to several genomic regions; for mild airflow obstruction in smokers only, the maximum LOD was

202 function, greater risk of the development of airflow obstruction in smokers, a predisposition to lowe

203 en Pneumocystis colonization and severity of airflow obstruction in smokers, suggesting a possible pa

204 usceptible (n = 64) to emphysema with severe airflow obstruction in the Pittsburgh Specialized Center

205 Data on the prevalence of airflow obstruction in the U.S. population were used to

206 ched among genes associated with more severe airflow obstruction in these COPD cohorts (P < 0.001), s

207 ammation and remodeling, although persistent airflow obstruction in these patients was associated wit

208 known about the pathophysiology of the fixed airflow obstruction in these subjects.

209 ay inflammation, airway wall remodeling, and airflow obstruction in this prevalent disease syndrome.

210 th should be recognised as a risk factor for airflow obstruction in young adults.

211 Although asthma typically induces reversible airflow obstruction, in some patients airflow obstructio

212 tive associations with emphysema with severe airflow obstruction, including a suggestive association

213 Airflow obstruction is a rare but fatal complication fol

214 inant of GCH in ever smokers with or without airflow obstruction is active smoking.

215 Undiagnosed airflow obstruction is common in the general population

216 If airflow obstruction is consistent with obliteration hist

217 Cohort studies suggest that airflow obstruction is established early in life, manife

218 exposed to organic dusts, the progression of airflow obstruction is related to the endotoxin concentr

219 In asthma, airflow obstruction is thought to result primarily from

220 defined by irreversible airflow obstruction; airflow obstruction is typically determined by reduction

221 isorder marked by inflammation and recurrent airflow obstruction, is associated with elevated levels

222 ed, which provided additional support for an airflow obstruction locus in that region with a non-para

223 te airflow obstruction (LOD = 2.13) and mild airflow obstruction (LOD = 1.43).

224 -parametric multipoint approach for moderate airflow obstruction (LOD = 2.13) and mild airflow obstru

225 EBC LXA4 levels correlate with the degree of airflow obstruction measured by using FEV1 (r = 0.28, P

226 The cardinal feature of COPD is persistent airflow obstruction, measured by reductions in quantitat

227 hort: the body-mass index (B), the degree of airflow obstruction (O) and dyspnea (D), and exercise ca

228 the two study groups by Day 6 for indices of airflow obstruction obtained from gamma-camera images of

229 ndent association between skin wrinkling and airflow obstruction of the lung.

230 Documenting reversible airflow obstruction on lung function, allergen sensitiza

231 t in contrast to asthma there is no variable airflow obstruction or airway hyperresponsiveness.

232 th all-cause mortality among persons without airflow obstruction or COPD in a general population samp

233 have shown significant associations between airflow obstruction or COPD with a non-synonymous SNP in

234 or more genes influencing the development of airflow obstruction or dysanapsis.

235 with isolated diaphragm weakness but without airflow obstruction or hyperinflation, a group that woul

236 ot appear to be a significant determinant of airflow obstruction or lower airway inflammation followi

237 iratory tract disease can manifest itself as airflow obstruction or viral pneumonia, which can be fat

238 ute worsening of asthma symptoms, reversible airflow obstruction, or bronchial hyperresponsiveness af

239 presented 5.7% of total referrals with fixed airflow obstruction over 2 years.

240 ream driver, whereas in subjects with severe airflow obstruction, pathways downstream of pathological

241 th muscle function and may contribute to the airflow obstruction phenotype observed in human CF.

242 h severe uncontrolled asthma and the chronic airflow obstruction phenotype.

243 exacerbations include previous exacerbation, airflow obstruction, poor overall health, home oxygen us

244 linear regression, for participants without airflow obstruction, PRM(fSAD) but not PRM(emph) was ass

245 Their effects in patients with milder airflow obstruction remain unclear.

246 n men and women is similarly associated with airflow obstruction, respiratory symptoms, more emphysem

247 cal CT can accurately demonstrate reversible airflow obstruction resulting from airway hyperreactivit

248 ations of asthma are thought to be caused by airflow obstruction resulting from airway inflammation,

249 .16, 1.03-1.32), and incompletely reversible airflow obstruction (RR 1.28, 1.04-1.57) than did those

250 odeling and narrowing, which account for the airflow obstruction similar to asthma.

251 Keywords: airflow obstruction; spirometry; health impact; screenin

252 r matrix (ECM) processes specifically in the airflow obstruction study.

253 sex), NO2 levels were associated highly with airflow obstruction, such that each 10-ppb increase in N

254 f an EEG arousal accentuated the response to airflow obstruction, such that the PAT amplitude decreas

255 provide evidence for significant linkage to airflow obstruction susceptibility loci on chromosomes 2

256 of the small airways leading to progressive airflow obstruction, termed bronchiolitis obliterans syn

257 se of smoking, women showed a higher risk of airflow obstruction than men.

258 syndrome (BOS) is a condition of progressive airflow obstruction that affects a majority of lung tran

259 ic obstructive pulmonary disease (COPD) have airflow obstruction that leads to dynamic lung hyperinfl

260 CHRNA5/3 region as a genetic risk factor for airflow obstruction that may be independent of smoking a

261 conclude that in the absence of significant airflow obstruction the volume of transplanted immature

262 tory and physical examination for predicting airflow obstruction; the value of spirometry for screeni

263 tics of chronic persistent asthma, including airflow obstruction, use of corticosteroid medications,

264 FEV(1) is an objective measure of airflow obstruction used in clinical practice and in the

265 In emphysema, airflow obstruction usually coexists with impairment of

266 COPD is characterised by poorly reversible airflow obstruction usually due to cigarette smoking.

267 ly, the maximum two point LOD score for mild airflow obstruction was 3.14.

268 ver diagnosed asthma and post-bronchodilator airflow obstruction was 44.8%, 19.3% and 7.5%, respectiv

269 Airflow obstruction was assessed by FEV1% predicted.

270 Health and functional impact of airflow obstruction was assessed from responses to quest

271 Increasing PRM(FSA) in subjects without airflow obstruction was associated with increased FVC (P

272 Airflow obstruction was defined as FEV(1) and its ratio

273 ealth and functional status with undiagnosed airflow obstruction was independently associated with se

274 Overall, airflow obstruction was less common and milder among PI*

275 bution relative to PRM(FSA) in those without airflow obstruction was limited by its low burden.

276 The extent of airflow obstruction was similarly associated with left v

277 Lack of airflow obstruction was the principal (89%) reason patie

278 Although undiagnosed airflow obstruction was usually very mild, approximately

279 lity and the predictors of age, dyspnea, and airflow obstruction were available.

280 Categories of diagnosed and undiagnosed airflow obstruction were defined using questionnaire res

281 eparate models for subjects without and with airflow obstruction were generated using baseline clinic

282 of emphysema on CT scanning and more severe airflow obstruction were linearly related to impaired le

283 Percent emphysema and airflow obstruction were not associated with the left ve

284 The agreement was less in the infants with airflow obstruction where the N2 washout gave slightly h

285 smoked pipes or cigars had increased odds of airflow obstruction whether they had also smoked cigaret

286 sorders encompassing different phenotypes of airflow obstruction, which might differ in their respons

287 Presence of airflow obstruction, which was defined by a baseline FEV

288 s were obese female patients with reversible airflow obstruction who exhibited airway wall thickening

289 te-onset older male subjects with persistent airflow obstruction who exhibited significant air trappi

290 edominance of patients with mild to moderate airflow obstruction who would not experience additional

291 In both sexes, the association of airflow obstruction with cigarettes per day, smoking dur

292 ual emphysema at CT demonstrated progressive airflow obstruction with lower values of ratio of forced

293 To assess the association of airflow obstruction with self-reported use of solid fuel

294 The association of airflow obstruction with smoking characteristics was ass

295 The association of airflow obstruction with smoking status was stronger in

296 re was also no evidence of an association of airflow obstruction with use of solid fuels (ORmen=1.00,

297 The association of airflow obstruction with use of solid fuels for cooking

298 idence supporting the association of COPD or airflow obstruction with use of solid fuels is conflicti

299 methods with GWASs of pulmonary function and airflow obstruction would identify a broader repertoire

300 alyses were conducted to identify effects on airflow obstruction, YKL-40 levels, and asthma severity.