ライフサイエンスコーパス: airway epithelium

1 a population resembling the stem cell of the airway epithelium.

2 human respiratory virus is delivered to the airway epithelium.

3 cells transfer MeV infectivity to the human airway epithelium.

4 f a subset of progenitor cells in the distal airway epithelium.

5 g mechanism that maintains quiescence in the airway epithelium.

6 on of the virus in polarized human bronchial airway epithelium.

7 derstanding of their interactions with human airway epithelium.

8 act innate antiviral immune responses in the airway epithelium.

9 . aeruginosa adhesion to and invasion of the airway epithelium.

10 insights into RSV interaction with pediatric airway epithelium.

11 ets for asthma intervention by targeting the airway epithelium.

12 hich to characterize its rapid spread in the airway epithelium.

13 PIV-3) infection is highly restricted to the airway epithelium.

14 uring infection of polarized human bronchial airway epithelium.

15 mily member 3), which is highly expressed in airway epithelium.

16 d mature multiciliated cells in a functional airway epithelium.

17 raction of M. pneumoniae with differentiated airway epithelium.

18 al cells in IPF express molecular markers of airway epithelium.

19 Sox2 expression and ultimately generates the airway epithelium.

20 specificity of smoking effects on the human airway epithelium.

21 that spores associated with the alveolar and airway epithelium.

22 zed to complementary domains surrounding the airway epithelium.

23 receptors and to alkaline phosphatase in the airway epithelium.

24 ive passage of inhaled allergens through the airway epithelium.

25 such studies have not been reported for the airway epithelium.

26 ) is a major pathogen that primarily infects airway epithelium.

27 , mobilization and secretion of IL-33 by the airway epithelium.

28 to IL-17-mediated downregulation of CRPs on airway epithelium.

29 the apical membrane of surface and glandular airway epithelium.

30 hich to study RSV cytopathogenesis in infant airway epithelium.

31 ain lung structure affected: alveolar versus airway epithelium.

32 M protein levels were increased in asthmatic airway epithelium.

33 secretion of cytokines and chemokines by the airway epithelium.

34 increasing cytokine and LTC(4) generation in airway epithelium.

35 ion of and the subsequent destruction of the airway epithelium.

36 ease of neutrophil proteases that damage the airway epithelium.

37 eractions between A. fumigatus and the human airway epithelium.

38 hat in blood and is tightly regulated by the airway epithelium.

39 , whereas the tracheal cells form a ciliated airway epithelium.

40 omote the goblet cell fate in the developing airway epithelium.

41 ial fibrosis, and increased thickness of the airway epithelium.

42 nterface to reproduce a fully differentiated airway epithelium.

43 ferent severities of asthma for studying the airway epithelium.

44 re PSMCs after naphthalene-induced injury to airway epithelium.

45 ntegrin and were closely associated with the airway epithelium.

46 ressing human SPLUNC1 exclusively within the airway epithelium.

47 ated cell membrane proteins in the polarized airway epithelium.

48 o anti-HPIV activity in cell lines and human airway epithelium.

49 acellular mucopolysaccharide staining in the airway epithelium.

50 ally infects the ciliated cells in the human airway epithelium.

51 s normally expressed in gastrointestinal and airway epithelium.

52 re also observed at the protein level in the airway epithelium.

53 measured by gene-expression profiling of the airway epithelium.

54 ic changes and perturb cilia function in the airway epithelium.

55 pendent interactions of Alt a 1 in the human airway epithelium.

56 ormal lung tissue to localize miR-200b-3p in airway epithelium.

57 ith complement deposition and destruction of airway epithelium.

58 shows the receptors are highly expressed in airway epithelium.

59 SM impair barrier function in differentiated airway epithelium.

60 of lactate dehydrogenase A occurring in the airway epithelium.

61 rmal and cystic fibrosis (CF) cultured human airway epithelium.

62 c activity that is capable of disrupting the airway epithelium.

63 st expression of miR-218-5p in the bronchial airway epithelium.

64 igration of neutrophils, using primary human airway epithelium.

65 d increases the rate of morphogenesis of the airway epithelium.

66 nism of dysregulated iron homeostasis of the airway epithelium.

67 chloride transport in cystic fibrosis human airway epithelium.

68 teration and preserved the morphology of the airway epithelium.

69 Airway epithelium acts as an initial defence barrier to

70 In human airway epithelium air-liquid interface (HAE-ALI) culture

71 similar upregulation of IL-33 protein in the airway epithelium, along with marked eosinophilic bronch

72 The deficiency of Splunc1 in mouse airway epithelium also results in increased biofilm form

73 We sought to examine sPLA2-X in the airway epithelium and airway wall of patients with asthm

74 ection by day 6, with virus detected in lung airway epithelium and brain.

75 reparative potential of primary human small airway epithelium and capillary endothelium and induces

76 nal gene deletion during the regeneration of airway epithelium and clonal organoid culture.

77 Dual infection induced severe damage to the airway epithelium and confluent pneumonia, similar to th

78 (FcRn), by Calu-3 cell layers simulating the airway epithelium and demonstrates FcRn-mediated cell as

79 d with a loss of the structural integrity of airway epithelium and dysfunction of the physical barrie

80 gin of asthma is orchestrated by a disrupted airway epithelium and further perpetuated by a predispos

81 with the lung through the cellularly diverse airway epithelium and goes on to drive development of mo

82 investigate the effects of IL-17 activity on airway epithelium and identified CXCL5 and MIP-2 as impo

83 ent COVID-19 pandemic, primarily targets the airway epithelium and in lungs can lead to acute respira

84 1/phosphotyrosine staining patterns in mouse airway epithelium and increased Muc1 tyrosine phosphoryl

85 ger innate immune signalling pathways in the airway epithelium and influence the initiation of the HD

86 in expression was significantly increased in airway epithelium and lamina propria of asthmatic patien

87 oring chemicals impair the cilia function in airway epithelium and likely contribute to the adverse e

88 profiles in prior studies performed on small-airway epithelium and lung parenchyma, suggesting that t

89 rnative NF-kappaB pathways occurs within the airway epithelium and may coordinately contribute to all

90 PTCH1 protein is up-regulated in COPD airway epithelium and may upregulate mucous expression.

91 onal TRPV1 channels are present in the human airway epithelium and overexpressed in the airways of pa

92 tion results in a loss of Nogo expression in airway epithelium and smooth muscle compared with nonall

93 eptor layilin is expressed apically in human airway epithelium and that cells infected with lentiviru

94 hree-dimensional finite element model of the airway epithelium and used it to simulate apical constri

95 d the expression of ERp57 in human asthmatic airway epithelium and used murine models of allergic ast

96 ice expressing or deficient in OGG1 in their airway epithelium and various molecular biological appro

97 Ear1 was also detected in airway epithelium and was reduced in lungs of mice expos

98 ls, which exhibit many features of the human airway epithelium, and colon epithelial cells to serve a

99 istry detected SAA was in close proximity to airway epithelium, and in vitro SAA triggered release of

100 g is initiated by apical constriction of the airway epithelium, and not by differential cell prolifer

101 to a shift in mast cell infiltration to the airway epithelium, and that mast cells cooperate with ep

102 dition) on the wound healing activity of the airway epithelium, and they enhanced the production of i

103 I IFN is the predominant IFN produced by the airway epithelium, and TLR3 is the only TLR that mediate

104 mucosa; proliferation of goblet cells in the airway epithelium; and the production of antigen-specifi

105 HuR-mediated regulation in airway epithelium appears broader than previously apprec

106 air pollution exposure, the defenses of the airway epithelium are compromised by reductions in barri

107 populations, cells of the homeostatic adult airway epithelium are long-lived, and little is known ab

108 small epithelial lesions in pseudostratified airway epithelium are missing.

109 ambda responses to dsRNA in the human infant airway epithelium are regulated by p38-MAPK and NF-kB si

110 e branching, the basement membrane wraps the airway epithelium as a spatially uniform sheath.

111 se results identify beta2AR signaling in the airway epithelium as capable of controlling integrated r

112 upregulated RIPK1 and MLKL expression in the airway epithelium at 8 to 10 days after infection, coinc

113 In the airway epithelium, basal cells function as stem/progenit

114 fied NLRP3 and caspase-1 expression in human airway epithelium bronchus and primary cells, (2) charac

115 ) lungs, cell proliferation increased in the airway epithelium but apoptosis increased in the blood v

116 Ablation of Sirt1 in airway epithelium, but not in myeloid cells, aggravated

117 colds, disrupts the barrier function of the airway epithelium by increasing reactive oxygen species

118 The airway epithelium can express factors that drive subepit

119 a reduced chemokine response from polarized airway epithelium cells compared to wild-type strains.

120 ne TGF-beta1 upregulates sialidases in human airway epithelium cells, lung fibroblasts, and immune sy

121 ng activities, and its capacity to stimulate airway epithelium cells.

122 Nasal airway epithelium cis-expression quantitative trait locu

123 Small wounds in the pseudostratified airway epithelium close within hours to preserve epithel

124 Our results demonstrate that human airway epithelium contains a functional NLRP3 inflammaso

125 on airway epithelial cells, we show that the airway epithelium controls a range of pathological respo

126 arning about the changes that develop in the airway epithelium could improve our understanding of ast

127 asmid and viral infection of polarized human airway epithelium cultured at an air-liquid interface (H

128 ocavirus 1 infects polarized human bronchial airway epithelium cultured at an air-liquid interface th

129 Conversely, in primary human airway epithelium cultured at the air-liquid interface,

130 us could be used to deliver CFTR to ciliated airway epithelium derived from CF patients, we inserted

131 The airway epithelium develops concomitantly with a layer of

132 The airway epithelium develops into a tree-like structure vi

133 SAE of smokers; and 5) ACE2 is expressed in airway epithelium differentiated in vitro on air-liquid

134 lts indicate that miR-4423 is a regulator of airway epithelium differentiation and that the abrogatio

135 to development, postnatal loss of Hdac1/2 in airway epithelium does not affect the expression of Sox2

136 this is comparable to that generated in the airway epithelium during bronchoconstriction in asthma.

137 n were enriched at the apical surface of the airway epithelium during monopodial branching.

138 e upregulation of P2Y4 and P2Y6 receptors in airway epithelium during sensitization.

139 or lung epithelial development, in the adult airway epithelium evokes a non-Th2 asthma phenotype that

140 olecule predominantly expressed in pulmonary airways epithelium, exhibits anti-inflammatory and growt

141 Thus, persistent NF-kappaB signaling in airway epithelium facilitates carcinogenesis by sculptin

142 Most respiratory viruses target airway epithelium for infection and replication, which i

143 The airway epithelium forms a barrier between the internal a

144 The airway epithelium forms the interface between the inhale

145 However, IRAK-M expression in airway epithelium from asthmatic patients and its functi

146 ay cilia and effective clearance of the lung airway epithelium from carcinogens.

147 viving variant Clara cells (the cells in the airway epithelium from which replacement epithelial cell

148 423 induces a differentiated-like pattern of airway epithelium gene expression and reverses the expre

149 ing a primary culture of mucus-covered human airway epithelium grown at air-liquid interface, without

150 COPD-associated expression in the bronchial airway epithelium had similarly altered expression profi

151 Infection of human cartilaginous airway epithelium (HAE) and a hamster model of disease w

152 vitro, HBoV1 infects polarized primary human airway epithelium (HAE) cultured at an air-liquid interf

153 ral host cell cultures, a model of the human airway epithelium (HAE) in which primary HAE cells are c

154 The steady-state airway epithelium has a low rate of stem cell turnover b

155 Rationale: Uninvolved normal-appearing airway epithelium has been shown to exhibit specific mut

156 The functional expression of TRPV1 on airway epithelium has yet to be elucidated.

157 Studies using ex vivo human airway epithelium have focused on virus tropism, cellula

158 and arginase (ARG), are typical in asthmatic airway epithelium; however, little is known about the me

159 rential expression of microRNA (miRNA) in CF airway epithelium; however, the role of miRNA in regulat

160 constitutively active IkappaB kinase beta in airway epithelium (IKTA (IKKbeta trans-activated) mice).

161 ored the cellular heterogeneity of the human airway epithelium in 10 healthy living volunteers by sin

162 quantifies multiple functional parameters of airway epithelium in a colocalized fashion.

163 The airway epithelium in alpha7 knockout mice is characteriz

164 The airway epithelium in asthma and upper airway diseases is

165 cell RNA sequencing (scRNA-Seq) to study the airway epithelium in asthma.

166 electively and effectively inhibit ORMDL3 in airway epithelium in asthma.

167 s that could facilitate investigation of the airway epithelium in future longitudinal pediatric studi

168 IL-22 receptor was localized to the airway epithelium in naive mice but was expressed at the

169 omatic mutational architecture of the normal airway epithelium in patients with early-stage NSCLC.Met

170 ght to examine mast cell infiltration of the airway epithelium in patients with EIB and the regulatio

171 lted in the persistence of K14+ cells in the airway epithelium in potentially premalignant lesions.

172 the production of pro-fibrogenic factors by airway epithelium in response to A fumigatus, in order t

173 etwork that regulates gene expression in the airway epithelium in response to endogenous and exogenou

174 some-mediated IL-1beta production from human airway epithelium in response to PM, and (3) performed i

175 ons of branches within the developing murine airway epithelium in the absence of mesenchyme.

176 differentiation to form the pseudostratified airway epithelium in the developing and adult lung.

177 EC models relative to RSV infection of human airway epithelium in vivo, and future directions for the

178 an authentic surrogate for RSV infection of airway epithelium in vivo.

179 ate that secretion of miRNAs in EVs from the airway epithelium, in particular miR-34a, miR-92b, and m

180 lating many physiological functions of human airway epithelium, including those involving cell morpho

181 RV-16 infection of human airway epithelium induces glucocorticoid resistance.

182 that selective IL-13 stimulation of Stat6 in airway epithelium induces murine AHR raise questions abo

183 to enhanced fusion and F is a key factor in airway epithelium infection, pathogenesis, and subsequen

184 IFN-gamma signaling through the airway epithelium inhibits eosinophil generation in the

185 IFN-gamma acting only through the airway epithelium inhibits mucus, chitinases, and eosino

186 Disruption of the airway epithelium is central to many lung diseases, and

187 The human airway epithelium is constantly exposed to microbial pro

188 pproaches are feasible, in part, because the airway epithelium is directly accessible by aerosol deli

189 We propose that initial folding of the airway epithelium is driven primarily by apical constric

190 The airway epithelium is dysfunctional in asthma and epigene

191 Integrity of the airway epithelium is essential for normal lung function.

192 The airway epithelium is exposed to a range of physical and

193 During pneumococcal pneumonia, the human airway epithelium is exposed to large amounts of H2O2 as

194 The airway epithelium is first barrier to interact with, and

195 er time, we demonstrate that the human upper airway epithelium is maintained by an equipotent basal p

196 understanding of the regulatory role of the airway epithelium is required to develop new therapeutic

197 The airway epithelium is seriously damaged upon pulmonary Ps

198 ow demonstrate that beta2AR signaling in the airway epithelium is sufficient to mediate key features

199 e, transgenic expression of beta2ARs only in airway epithelium is sufficient to rescue IL-13-induced

200 The airway epithelium is the first barrier encountered by re

201 Airway epithelium is the first body surface to contact i

202 The airway epithelium is the first line of defense against i

203 The airway epithelium is the first line of host defense agai

204 The respiratory mucosa formed by the airway epithelium is the first point of contact for air

205 A characteristic feature of the human airway epithelium is the presence of ciliated cells bear

206 Airway epithelium is the primary target of many respirat

207 The physical barrier function of the airway epithelium is tightly interwoven with its immunom

208 D smokers (n = 36), with corresponding large airway epithelium (LAE) data included in a subset of sub

209 3(-), a process which is dysfunctional in CF airway epithelium leading to ASL acidification and that

210 munological and physical barrier function of airway epithelium, leading to allergic sensitization, ai

211 ity of this tool by using the example of the airway epithelium lineage.

212 lial function/secretion, suggesting that the airway epithelium may be particularly important in asthm

213 ized that effects of mineral exposure in the airway epithelium may dictate deviating molecular events

214 Barrier dysfunction of airway epithelium may increase the risk for acquiring se

215 uestering kaiso in the nucleus of a smoker's airway epithelium may represent a novel approach of trea

216 y chemoreceptors offers a means by which the airway epithelium may trigger an epithelial inflammatory

217 Bronchial airway epithelium may ultimately serve as a relatively a

218 er-sensing complex, plays a critical role in airway epithelium-mediated immune responses to urban par

219 protein that likely plays a critical role in airway epithelium-mediated innate immune response.

220 ght into the expression of ACE2 in the human airway epithelium.Methods: Airway epithelia sampled by f

221 ave raised the concern that desialylation of airway epithelium might increase susceptibility to Strep

222 indirect airway hyperresponsiveness, and the airway epithelium might serve as an important regulator

223 ies to inhibit ERp57 specifically within the airways epithelium might provide an opportunity to allev

224 Our results demonstrate that the human airway epithelium mounts virus-specific immune responses

225 d lung microbiome, bacterial invasion of the airway epithelium, NF-kappaB activation, leukocyte infil

226 CE2 (angiotensin-converting enzyme 2) on the airway epithelium.Objectives: The objective was to gain

227 dysregulated repair programs are evident in airway epithelium obtained from patients with BOS, parti

228 show that ERp57 levels are increased in the airway epithelium of asthmatic patients and in mice with

229 ecently been shown to be up-regulated in the airway epithelium of asthmatics and to increase active T

230 ork among 5492 genes expressed in human lung airway epithelium of healthy non-smokers, healthy smoker

231 distribution of OPN-expressing cells in the airway epithelium of normal lung tissue and that from pa

232 STUB1 expression was evaluated in airway epithelium of patients with asthma and lung tissu

233 TAK1 phosphorylation was increased in the airway epithelium of patients with fibrotic airway disea

234 along with increased Il33 expression in the airway epithelium of Scnn1b-Tg mice.

235 The airway epithelium of smokers acquires pathological pheno

236 ceptible to pulmonary infection and that the airway epithelium of smokers with chronic obstructive pu

237 ter methylation in cells exfoliated from the airway epithelium of smokers.

238 The pseudostratified airway epithelium of the lung contains a balanced propor

239 Branching morphogenesis sculpts the airway epithelium of the lung into a tree-like structure

240 Pseudostratified airway epithelium of the lung is composed of polarized c

241 pressing an ovalbumin transgene in the small airway epithelium of the lungs (CC10-OVA mice).

242 modeling (TGF-beta1, ADAM8) were detected in airway epithelium of these mice.

243 ional deletion of the Foxm1 gene from either airway epithelium or myeloid inflammatory cells decrease

244 rate mice selectively deficient in ORMDL3 in airway epithelium (Ormdl3(Delta2-3/Delta2-3)/CC10) to si

245 ts: Ceramide is increased in cystic fibrosis airway epithelium owing to differential function of enzy

246 Expanded cells can produce functional airway epithelium physiologically responsive to clinical

247 Insults to the airway epithelium play a key role in constrictive bronch

248 ndicate that the cellular composition of the airway epithelium plays an important role in OPN express

249 The airway epithelium plays an important role in wound repai

250 The airway epithelium possesses many mechanisms to prevent b

251 transcriptomic alterations in the bronchial airway epithelium reflect molecular events found at more

252 ng is essential for lung development and the airway epithelium regeneration and repair.

253 on and antagonism of host responses by human airway epithelium remains poorly understood.

254 sely, loss of Npy in Foxp1- and Foxp4-mutant airway epithelium rescued the AHR phenotype.

255 rface cultures to demonstrate that the human airway epithelium responds to apical stimulation by A. f

256 The airway epithelium responds to such infections by releasi

257 Expression microarrays of the airway epithelium revealed mast cell proteases among the

258 Analysis of the airway epithelium revealed that EGFR is enriched in airw

259 The small airway epithelium (SAE), the first site of smoking-induc

260 e between host and external environment, the airway epithelium serves as a major protective barrier.

261 In airway epithelium, SMAD signaling promotes differentiati

262 Upon colonization of the airway epithelium, specific host cell receptors interact

263 ere we sought to examine the contribution of airway epithelium-specific ERp57 in the pathogenesis of

264 hift in mast cells from the submucosa to the airway epithelium specifically associated with both type

265 Recent research shows that airway epithelium stem cells divide mostly asymmetricall

266 posure increased periostin expression in the airway epithelium, subepithelium, smooth muscle and infl

267 bility genes for asthma are expressed in the airway epithelium, supporting the notion that events at

268 rtion of ciliated cells in cultures of human airway epithelium than did viruses with 222D or 222E, wh

269 identified specific methylation profiles in airway epithelium that are associated with atopy and ato

270 , these factors act locally on a susceptible airway epithelium that is both structurally and function

271 ific gene expression signatures in bronchial airway epithelium that reflect activation of signaling p

272 ing alters expression of TLRs in human small airway epithelium, the primary site of smoking-induced d

273 In damaged airway epithelium, they are exposed directly to aeroalle

274 House dust mite (HDM) acts on the airway epithelium to induce airway inflammation in asthm

275 play a critical role in the response of the airway epithelium to injury and are recently recognized

276 ess an activator of the NF-kappaB pathway in airway epithelium to investigate the impact of epithelia

277 The response of the CF airway epithelium to the opportunistic pathogen Pseudomo

278 the importance of paracrine signals from the airway epithelium to the underlying smooth muscle to ind

279 erved in bronchoalveolar lavage macrophages, airway epithelium, vascular endothelium, and airway smoo

280 hese data indicate that RSV infection of the airway epithelium, via the action of NS2, promotes epith

281 titative analysis of NF-kappaB activation in airway epithelium was accomplished using a polyclonal an

282 activity in cultured cell lines and in human airway epithelium was assessed by the reduction in viral

283 The airway epithelium was mostly preserved in syngeneic graf

284 sing an in vitro model of the differentiated airway epithelium, we found that the addition of physiol

285 Because the influenza virus is tropic to the airway epithelium, we investigated the role of syndecan-

286 p understand RSV interactions with pediatric airway epithelium, we previously developed three-dimensi

287 terial biofilm formation associated with the airway epithelium, we show that respiratory viral infect

288 r transgenic mice overexpressing Grx1 in the airway epithelium were analyzed after infection with P.

289 ly active IkappaB kinase beta (CAIKKbeta) in airway epithelium were tolerized to inhaled ovalbumin.

290 TSLP expression was localized to the airway epithelium, whereas IL-33 was expressed in epithe

291 eal rings, an effect that depended on intact airway epithelium, whereas mMCP-4 inhibited IL-13-induce

292 TLR7 deficiency increased viral load in the airway epithelium, which became sloughed and necrotic, a

293 itative data on the recovery dynamics of the airway epithelium, which can include secretory cell de-d

294 were accompanied by increased disruption of airway epithelium, which was reversed by therapeutic blo

295 IFN-gamma actions through the airway epithelium will limit airway obstruction and infl

296 sustains arginine availability in asthmatic airway epithelium with consequences for bioenergetics an

297 tides results in peptide accumulation in the airway epithelium with minimal systemic levels of peptid

298 ace (ALI) usually provide a pseudostratified airway epithelium with similar abnormalities than origin

299 ich human PLUNC (hPLUNC) was directed to the airway epithelium with the Scgb1a1 promoter.

300 or for SARS-CoV-2, is expressed in the human airway epithelium, with variations in expression relevan