ライフサイエンスコーパス: alanine

1 Ser722 and Ser792 of RAPTOR were mutated to alanine.

2 mpounds, focusing on the smallest amino acid alanine.

3 lf the Pro3 or Pro6 residues are replaced by alanine.

4 y related CLK3 which harbors a smaller DFG-1 alanine.

5 activity is influenced by the abundance of L-alanine.

6 IQGAP1 construct by replacing Tyr-1510 with alanine.

7 ta-hydroxybutyrate, trimethyl uric acid, and alanine.

8 rough condensation of these amines with beta-alanine.

9 elevant two serine residues were replaced by alanine.

10 significant accumulation of extracellular D-alanine.

11 lu residues in the motif were substituted by alanine.

12 types studied, though still more basic than alanine.

13 on substitution of catalytic acid Asp-239 by alanine.

14 l but the arginine residues were replaced by alanine.

15 ed lactate, S-lactoylglutathione, N-acetyl-l-alanine, 2-hydroxyglutarate, and UMP levels.

16 erminal Lys with isotopically labeled acetyl-alanine; (3) thiol Michael addition of an isotopically l

17 pA/PreNAC complex displays a contact between alanine 53 of alpha-synuclein and glutamine 111 in the c

18 Mutation of alanine 53 to glutamate, as found in patients with early

19 dequate molecular features, it is, owning an alanine (A) as their penultimate N-terminal residue (e.g

20 recipitation studies reveal that the R205 to alanine (A) mutant of YBX1 (YBX1-R205A) interacted less

21 V FP were substituted with neutrally charged alanines (A).

22 one carrying substitution of IN serine 57 to alanine, a mutation known to impair viral DNA integratio

23 mined whether mutation of these cysteines to alanine affects differentially Tau mediated toxicity and

24 Alanine (Ala) accumulated to about 35% of total amino ac

25 at 160 degrees C from d-glucose (Glc) and l-alanine (Ala) as well as from fructosylalanine - the cor

26 1/FLI1-T79A, containing a threonine (Thr) to alanine (Ala) substitution at amino acid 79, failed to i

27 ghly conserved tyrosine residue (Y382), into alanines also delayed the activation rate.

28 tamate (EcE65/AaE64), which, when mutated to alanine, also enhances the production of siRNA-like prod

29 ial protein, the putative N-acetylmuramoyl-l-alanine amidase RC0497.

30 including gamma-glutamyl transferase (GGT), alanine aminopeptidase (AAP), and N-acetyl-beta-d-glucos

31 onths (symptomatic seroconversion illness or alanine aminotransferase > 10 x upper limit of normal) o

32 dermatitis acneiform (20 [9%]) and increased alanine aminotransferase (17 [8%]).

33 mmon adverse events were increased levels of alanine aminotransferase (64%) and aspartate aminotransf

34 lation, including nitrate reductase (NR) and alanine aminotransferase (AlaAT), were induced during se

35 cluded HBV DNA >=2000 IU/mL, with or without alanine aminotransferase (ALT) >=2-fold the upper limit

36 positive women and HBeAg-negative women with alanine aminotransferase (ALT) >=40 IU/L as a predictor

37 amma-glutamyl transferase (-30%; P < 0.001), alanine aminotransferase (ALT) (-49%; P = 0.009), and as

38 pectively), corrected T1 (cT1; -8% and -9%), alanine aminotransferase (ALT) (-67% and -60%), aspartat

39 rtate aminotransferase (AST) was higher than alanine aminotransferase (ALT) at admission (46 vs. 30 U

40 increased BM sproc recruitment, and reduced alanine aminotransferase (ALT) by 92% and 77% at 5 weeks

41 ges in qualitative serum HBsAg, HBV DNA, and alanine aminotransferase (ALT) concentrations in additio

42 Analysis of peak values of alanine aminotransferase (ALT) during COVID-19 showed mo

43 Interpretations of elevated blood levels of alanine aminotransferase (ALT) for drug-induced liver in

44 otential mediating role of viral load and/or alanine aminotransferase (ALT) in the relation of smokin

45 RS was associated with an increase in plasma alanine aminotransferase (ALT) level of 26% in those wit

46 aminotransferase (AST) and 35% had elevated alanine aminotransferase (ALT) levels on admission.

47 Correlates of FLD and its relationship with alanine aminotransferase (ALT) overtime were examined in

48 ted positive and had higher initial and peak alanine aminotransferase (ALT) than those who tested neg

49 The primary endpoint was the time for serum alanine aminotransferase (ALT) to fall below 100 U/L.

50 were metabolically abnormal or had elevated alanine aminotransferase (ALT) were higher than among th

51 L), high-density lipoprotein, triglycerides, alanine aminotransferase (ALT), and aspartate aminotrans

52 levated gamma-glutamyl transferase (GGT) and alanine aminotransferase (ALT), and higher number of hea

53 ic acids and flavones reduced blood glucose, alanine aminotransferase (ALT), aspartate aminotransfera

54 of salivary concentrations of total protein, alanine aminotransferase (ALT), aspartate aminotransfera

55 ere constructed using baseline and change in alanine aminotransferase (ALT), aspartate aminotransfera

56 three groups: patients with steatosis/normal alanine aminotransferase (ALT), steatosis/elevated ALT,

57 P( KO) mice fed an HFD exhibited lower serum alanine aminotransferase (ALT)/aspartate aminotransferas

58 ctinib-related adverse events were increased alanine aminotransferase (eight [3%] of 260 patients), a

59 ed by increased leukocyte count (P < .0001), alanine aminotransferase (P = .024), and aspartate trans

60 enia (six [5%] vs three [4%]), and increased alanine aminotransferase (six [5%] vs two [3%]).

61 elated serious adverse events were increased alanine aminotransferase (two [<1%] of 260 patients), in

62 routinely assayed in clinical laboratories (alanine aminotransferase 1, C-reactive protein, and myog

63 In a mouse model of ALD, liver injury (alanine aminotransferase [ALT]) and steatosis were preve

64 ver tests (aspartate aminotransferase [AST], alanine aminotransferase [ALT], alkaline phosphatase [AL

65 histological staining, measurement of serum alanine aminotransferase activity, and expression analys

66 ation was accompanied by decreased levels of alanine aminotransferase and aspartate aminotransferase

67 verse events were rash (89 [56%]), increased alanine aminotransferase concentrations (74 [46%]), and

68 ropenia (15 [50%] of 30 patients), increased alanine aminotransferase concentrations (two [7%] patien

69 0%] of 425 patients in the sunitinib group), alanine aminotransferase increase (54 [13%] vs 11 [3%]),

70 (39.1% vs 28.1%), pyrexia (38.7% vs 26.0%), alanine aminotransferase increased (33.9% vs 22.8%), and

71 rtension (in 21% of the patients), increased alanine aminotransferase level (in 11%), increased aspar

72 Liver enzyme levels were elevated, with an alanine aminotransferase level of 48 U/L (0.80 ukat/L) (

73 Liver enzyme levels were elevated, with an alanine aminotransferase level of 48 U/L (0.80 ukat/L) (

74 The alanine aminotransferase levels decreased from 79.9 +/-

75 de association study combining cirrhosis and alanine aminotransferase levels performed in 5 discovery

76 72,705 controls and 362,539 individuals with alanine aminotransferase levels).

77 xcept lactate correlated with EAD, 90-minute alanine aminotransferase showing the highest area under

78 an isolated grade 4 increase in the level of alanine aminotransferase that led to treatment discontin

79 For all subjects combined, alanine aminotransferase was reduced by 15.8 +/- 8.4% (P

80 on, and hyperkalaemia, and grade 4 increased alanine aminotransferase were reported in one patient ea

81 HBV DNA target not detected, normal level of alanine aminotransferase) after removal of all therapy.

82 ts indicated a causal role of increased ALT (alanine aminotransferase) in the development of type 2 d

83 e, HBV DNA below 2000 IU/mL, normal level of alanine aminotransferase) or functional cure (HBsAg belo

84 ymes than control group (mean difference for alanine aminotransferase, aspartate aminotransferase, al

85 We assessed concentrations of alanine aminotransferase, aspartate aminotransferase, an

86 (P < 0.01) serum total lipids, cholesterol, alanine aminotransferase, aspartate aminotransferase, an

87 ction in ALP had greater reductions in serum alanine aminotransferase, aspartate aminotransferase, ga

88 ver follow-up time, with increasing level of alanine aminotransferase, hemoglobin A1C (P<.05), gamma-

89 values of aspartate aminotransferase (AST), alanine aminotransferase, lactate dehydrogenase, and cre

90 parameters (PP) (aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, glucose

91 de levels and improved liver markers such as alanine aminotransferase, NAFLD activity score, and fibr

92 22% had advanced fibrosis and 54% had normal alanine aminotransferase.

93 POD3 of 7 total bilirubin and alanine aminotransferase; POD3 aspartate aminotransferas

94 o resulted in hypersusceptibility to DCS, an alanine analogue antibiotic that inhibits alanine racema

95 Mutational analysis of the LLI sequence with alanine and arginine substitutions showed that its overa

96 alpha-hydroxy-4-cholesten-3-one, bile acids, alanine and aspartate aminotransferases, and neoepitope-

97 residues (seven in both TMHs 6 and 12) with alanine and generated a mutant termed 14A.

98 so show that Dat mediates the synthesis of D-alanine and its activity is influenced by the abundance

99 ate the general applicability of our method, alanine and other amino acids were analyzed from soy sau

100 rammes a metabolic network involving serine, alanine and pyruvate that drives the endogenous synthesi

101 e stalled polypeptides with carboxy-terminal alanine and threonine residues (CAT tails).

102 APC [APC with lysine 191-193 replaced with 3 alanines and arginine 229/230 replaced with 2 alanines])

103 a-(piperidin-1-yl)alanine, beta-(azepan-1-yl)alanine, and fluorescent and ciprofloxacin-containing am

104 is instantaneously hydrolyzed to [1-(13)C]-l-alanine, and subsequently metabolized to [1-(13)C]lactat

105 sparagine (Asx), glutamic acid/glutamine and alanine are positively correlated with seawater pCO(2) a

106 noncanonical 1-deoxysphingolipids when using alanine as a substrate(4,5).

107 Glutamate, glutathione, lactate, and alanine, as well as interleukin (IL)-1beta and IL-8, inc

108 Substitution to helix-enhancing alanine at either of these positions dramatically enhanc

109 in sensitivity, and that simply changing the alanine at position 578 in the S4-S5 helix of the chicke

110 to PKa was prepared by replacing Arg371 with alanine at the activation cleavage site (PK-R371A, or si

111 d gene, dat, can support slow growth of an L-alanine auxotroph.

112 th tetrapeptide alanine-valine-phenylalanine-alanine (AVFA), a fragment of RuBisCO.

113 lysophosphatidic acid, trypsin, SLIGRL, beta-alanine, BAM8-22), and scratching was assessed using a m

114 method to show that skeletal muscle-derived alanine becomes rate controlling for hepatic mitochondri

115 lysophosphatidylcholines, triglycerides, and alanine before GADA-first.

116 eta-benzylaminoalanine, beta-(piperidin-1-yl)alanine, beta-(azepan-1-yl)alanine, and fluorescent and

117 ed the major enzymes involved in B. subtilis alanine biosynthesis and identified an alanine permease,

118 ugh some of the purified enzymes involved in alanine biosynthesis have been shown to catalyze reversi

119 beta-N-methylamino-l-alanine (BMAA) is a nonproteinogenic amino acid that has

120 environmental neurotoxin beta-methylamino-L-alanine (BMAA).

121 iscrete, we generated six charged cluster-to-alanine (CCTA) mutants within the UL148 ectodomain and c

122 orus (i.e. the junction with the stomach) of alanine, choline compounds, creatine, leucine and valine

123 s: Valine (coded by GUX [X = U, C, A or G]), alanine (coded by GCX), aspartic acid (coded by GAY [Y =

124 class of Ser codons, UCX, were derived from alanine codons, GCX, distinctly different from the other

125 Methionine and alanine, compounds produced in BCAA metabolism and fatty

126 e skeletal total amino acid, Asx, serine and alanine concentrations combined with the calcification m

127 ders glucose binding because its mutation to alanine converts the AncMsPFK enzyme into a specific ADP

128 One ATP-grasp enzyme, d-alanine-d-alanine ligase (Ddl), catalyzes ATP-dependent

129 rs, two novel variants of genes encoding a D-alanine-D-alanine ligase (ddl6 and ddl7) located within

130 Their substitution to alanine decreased high-molar-mass alternan yield by a th

131 Finally, we discover that alanine dehydrogenase is involved in ammonium assimilati

132 SigG1 regulates the expression of alanine dehydrogenase, ald and the WhiB-like regulator,

133 conclude that the lack of AnxA6 compromises alanine-dependent GNG and liver regeneration in mice.

134 -/-) mice was the consequence of an impaired alanine-dependent GNG in AnxA6(-/-) hepatocytes.

135 Here, we developed a (13)C-labeled alanine derivative, [1-(13)C]-l-alanine ethyl ester, as

136 es ATP-dependent formation of the d-alanyl-d-alanine dipeptide essential for bacterial cell wall bios

137 nd that mutation of threonine (T) T923 to an alanine disrupted synaptic trafficking.

138 ank3 residues (949)Arg-Arg-Lys(951) to three alanines disrupts CaMKII binding in vitro and CaMKII ass

139 the S/T residues have been substituted with alanines does not.

140 a knockin mouse in which S600 was mutated to alanine (Drp1S600A).

141 ral studies of antibody-antigen complexes by Alanine et al., Urusova et al., and Rawlinson et al. def

142 Following cell transport, [1-(13)C]-l-alanine ethyl ester is instantaneously hydrolyzed to [1-

143 Alanine ethyl ester readily crosses cell membrane while

144 13)C-labeled alanine derivative, [1-(13)C]-l-alanine ethyl ester, as a viable DNP probe whose chemica

145 Expression of alanine-expanded PABPN1 is linked to the formation of nu

146 odel where altered protein interactions with alanine-expanded PABPN1 that lead to loss or gain of fun

147 Soil microbes appeared to remove alanine from soil solution within 1 min and release enou

148 ow has a major role in the assimilation of D-alanine from the environment.

149 type, a charge-scrambled, a phenylalanine-to-alanine (FtoA), and an arginine-to-lysine (RtoK) mutant

150 share a glycine-phenylalanine-hydroxyproline/alanine (GFO/A) motif that is recognised by the enzyme i

151 Strecker aldehydes was also demonstrated in alanine/glucose and in a bread model systems using [(13)

152 ponent analysis, we observed that glutamine, alanine, glutathione, and lactate were positively associ

153 of hexose monophosphate, pyruvate, lactate, alanine, glycerol-3 phosphate, and isocitrate were signi

154 glutamine catabolism, such as glutamic acid, alanine, glycine, pyrimidine, and creatine.

155 Herein, we present a versatile acetyl-alanine-glycine (Ac-AG) tag that conceals quantitative i

156 tant mice in which Ser21 is substituted with alanine (GRK1-S21A), preventing dark-dependent phosphory

157 he DDR, tyrosine 142 (Y142), is converted to alanine (H2ax-Y142A).

158 l arylsulfones as dipolarophiles and glycine/alanine iminoesters as azomethine ylide precursors has b

159 framework, whereby serine is substituted for alanine in the fifth position, provided the most potent

160 We mutated K4 or K36 to alanine in the histone variant H3.3 and showed that the

161 econd threonine of the TTVGYG sequence by an alanine in the hKv2.1 and hKv3.1 channels, which are kno

162 tes on serines 63, 68, and 69 are mutated to alanines), in which phospholemman is rendered unphosphor

163 ates of alanine turnover, assessed by [3-13C]alanine, in a subgroup of participants under similar fas

164 racemase and d-alanine ligase required for d-alanine incorporation into cell wall peptidoglycan.

165 n channel downstream of MrgprD, and the beta-alanine-induced calcium signal was attributed mostly to

166 Mutation of H3K36 to arginine or alanine inhibits H3K27 methylation by PRC2 on nucleosome

167 ing a single and double deletion or a single alanine insertion in the large (L) polymerase protein th

168 ying a single or double deletion or a single alanine insertion were genetically stable, highly attenu

169 te alanine, the primary synthetic enzyme for alanine is encoded by alaT, although a second gene, dat,

170 te of the polymerase domain were replaced by alanine is highly toxic to E. coli cells.

171 Under metabolic stress, alanine is the main hepatic gluconeogenic substrate, and

172 One ATP-grasp enzyme, d-alanine-d-alanine ligase (Ddl), catalyzes ATP-dependent formation

173 vel variants of genes encoding a D-alanine-D-alanine ligase (ddl6 and ddl7) located within gene casse

174 ibiotic that inhibits alanine racemase and d-alanine ligase required for d-alanine incorporation into

175 utamic acids (mdxS3E) or nonphosphorylatable alanines (mdxS3A).

176 pulses with either N-acetylmuramic acid or D-alanine metabolic probes showed that cell wall growth is

177 g auxotrophic markers, the genes involved in alanine metabolism have not been characterized fully.

178 This work provides valuable insights into alanine metabolism that suggests that the relative abund

179 SPT therefore links serine and mitochondrial alanine metabolism to membrane lipid diversity, which fu

180 Ten (lactic acid, alanine, methionine, fumaric acid, inosine, inosine mono

181 ests that the relative abundance of D- and L-alanine might be linked with cytosolic pool of D and L-g

182 ion in murine Nkx3.1 to code for a serine to alanine missense at amino acid 186, the target for Dyrk1

183 onserved aspartate-glutamate-leucine-leucine-alanine motif) competitively inhibit the GID1-NGR5 inter

184 An alanine mutagenesis analysis reveals that two receptor s

185 Alanine mutagenesis has identified residues that disrupt

186 Furthermore, kinetic analysis of active site alanine mutants indicates that carbapenem hydrolysis is

187 Serine-to-alanine mutation at position 53 of the Kv7.5 amino termi

188 Each alanine mutation elicited a distinctive off-pathway dist

189 Yeast cells with arginine-to-alanine mutations in the H4 basic patch (H4(2RA)) exhibi

190 Alanine mutations in the sequence between amino acids 37

191 Alanine mutations of all 11 phosphorylation sites on the

192 n the fifth glycine of cross-bridges and the alanine of the adjacent stem peptide.

193 e, and higher waist circumference, levels of alanine or aspartate aminotransferase, total and low-den

194 Replacement of Arg-177 in PKG1alpha with alanine or methionine also increased basal activity.

195 Mutations of Cys69 with alanine or serine show 5hmC-specificity that mirrors the

196 APC [APC with lysine 191-193 replaced with 3 alanines] or 5A-APC [APC with lysine 191-193 replaced wi

197 the mitochondrial pyruvate carrier promotes alanine oxidation to mitigate deoxysphingolipid synthesi

198 Alanine (p <= 0.011), tyrosine (p <= 0.014) and formate

199 t changes an aspartic acid at position 50 to alanine (p.D50A), resulting in intellectual disability i

200 Introducing the cleavable arginine-alanine peptide into the NAc attenuated expression of co

201 tilis alanine biosynthesis and identified an alanine permease, AlaP (YtnA), which we show has a major

202 derwent simultaneous fluorodihydroxyphenyl-l-alanine PET (18F-DOPA-PET) and resting state functional

203 Rather, amino acids alanine, phenylalanine, glutamic acid, valine, and leuci

204 Both isomeric forms of alanine play a crucial role in bacterial growth and viab

205 mutant human superoxide dismutase glycine to alanine point mutation at amino acid 93 (hSOD1(G93A)) mo

206 active site of pol beta, 35, 68, and 72, to alanine (pol beta KDelta3A) increased the binding affini

207 cted a prospective [(18)F]-dihydroxyphenyl-L-alanine positron emission tomography study in antipsycho

208 m metabolites, 1-(13) C-lactate and 1-(13) C-alanine, predicted histological viability.

209 on of a single residue in beta1, Cys-162, to alanine prevented palmitoylation, reduced the level of b

210 Mutating Ser162 to Alanine produces constitutive activity, whereas the phos

211 ffect on S-acylation, but extended and rigid alanine-proline repeats perturbed it.

212 an alanine analogue antibiotic that inhibits alanine racemase and d-alanine ligase required for d-ala

213 FigC belongs to a new subfamily of alanine racemase-fold PLP-dependent decarboxylases that

214 exposed residues that, when substituted with alanine, reduce antagonism of GDF8 in full-length WFIKKN

215 Here, we report that alanine repeat expansions in the HOXD13 TF, which cause

216 Moreover, we found that an alanine residue adjacent to the GXXG loop is critical fo

217 e alcove through introduction of the smaller alanine residue in the F229A variant diminishes conversi

218 e-derived fatty acid and a rare dehydro-beta-alanine residue.

219 Replacement of Asp506 and Asp571 for alanine residues abolishes enzyme activity, thus identif

220 cterized by a stretch of amino acids rich in alanine residues that are organized into a hydrophobic,

221 hich the 2 cysteine residues are replaced by alanine residues, impairs the generation of induced plur

222 ides, containing either normal or deuterated alanine residues, were used to confirm the presence and

223 The pH-insensitive alanine resonance was used as a reference.

224 Replacement of these residues with alanine results in decreased methylation activity and ch

225 nism of substrate-buffering by myristoylated alanine-rich C kinase substrate (MARCKS) and two newly c

226 phospholipid binding domain of Myristoylated alanine-rich C-kinase substrate (MARCKS) could serve as

227 Myristoylated alanine-rich C-kinase substrate (MARCKS) is an intracell

228 odels with an original marker, myristoylated alanine-rich C-kinase substrate phosphorylated at serine

229 ed increased activation of the Ste20 proline alanine-rich kinase-Na+-Cl- cotransporter (SPAK-NCC) pho

230 g a SUMO acceptor site, a central disordered alanine-rich motif, a proline-rich domain, and a transac

231 e report that mice harboring a serine 365-to-alanine (S365A) mutation in STING are unexpectedly resis

232 Utilizing Mut-Seq to analyze an alanine scan library of Lit alleles, we identified two s

233 an important paramyxoviral model to perform alanine scan mutagenesis and a series of multidisciplina

234 Here we conducted an alanine scan of active site constituents that engage the

235 An alanine scan of apelin-17 reveals that the integrity and

236 hin the target peptide through computational alanine scanning anticipates not only the key residues f

237 Furthermore, in silico alanine scanning calculations of the last 21 residues of

238 In combination with alanine scanning mutagenesis and activity measurements w

239 Here, we use a systematic alanine scanning mutagenesis approach to understand the

240 Alanine scanning revealed decreased inhibition by the ap

241 per-residue decomposition calculations, and alanine scanning studies are done to provide further ins

242 By sequence analysis and computational alanine scanning we identify key residues and motifs inv

243 gar binding and catalysis were identified by alanine scanning, D36 being a critical residue for F6P b

244 raction, demonstrating that structure-guided alanine-scanning and computational modeling can serve as

245 t of programmes for performing computational alanine-scanning mutagenesis (CASM) to guide experiments

246 ne the Rab5-p110beta interface, we performed alanine-scanning mutagenesis and analyzed Rab5 binding w

247 In experimental protein engineering, alanine-scanning mutagenesis involves the replacement of

248 ght interact and bind alpha2-AP, and used an alanine-scanning mutagenesis method to select residues h

249 Alanine-scanning mutagenesis of Qtip shows that its loca

250 Herein, we used structure-guided alanine-scanning mutagenesis to map the functional epito

251 Alanine-scanning of the peptide identified three key res

252 Using alanine-substituted BigDyn analogs, we find that the Big

253 Expression of alanine-substituted, phosphodeficient GFP-gle1A(6A) prom

254 d repressor activities, using a ParA with an alanine substitution at Arg(351), a residue previously p

255 t that knock-in mice harboring a cysteine-to-alanine substitution at Krt14's codon 373 (C373A) exhibi

256 Sprouty1 knockin mice bearing a tyrosine-to-alanine substitution in position 53, corresponding to th

257 ling process because a YAP1 mutant harboring alanine substitutions (Mt-YAP5SA) in LATS1 kinase recogn

258 ino acids 363 and 394 having four additional alanine substitutions (STANT + 7A) reduced desensitizati

259 of Klebsiella oxytoca NasR to site-directed alanine substitutions and measured RNA-binding activity.

260 Except for P478A and K505A R508A, alanine substitutions at conserved residues abolished GP

261 nt ASIC1a bearing truncation or glutamate-to-alanine substitutions at distal NT causes constitutive c

262 Using the DNA-PKcs (5A) mouse model carrying alanine substitutions at the T2609 cluster, here we show

263 The 3D(pol) NLS alanine substitutions of T19 and L21 results in aberrant

264 ted by the orthosteric agonists GABA or beta-alanine, the allosteric agonist propofol, or combination

265 ave a biochemical activity that can generate alanine, the primary synthetic enzyme for alanine is enc

266 composition-arginine, lysine, aspartic acid, alanine, threonine and low levels of isoleucine and meth

267 ate; that transition was abolished with high-alanine TnT.

268 es the replacement of selected residues with alanine to determine the energetic contribution of each

269 ng tRNA, as exemplified by AlaRS mischarging alanine to G4:U69-containing tRNAThr.

270 viruses containing amino acid substitutions alanine to threonine at residues 125 (A125T) and 151 (A1

271 Addition of glycine and alanine together doubled high impact pyrazines and addit

272 actate dehydrogenase ([1-(13)C]lactate), and alanine transaminase ([1-(13)C]alanine) was assessed.

273 ndex (BMI) (aOR, 1.58 per 1 kg/m2; P < .01), alanine transaminase (ALT) (aOR, 1.76 per 10 U/L; P < .0

274 ociation of rs72613567 with plasma levels of alanine transaminase (ALT) and clinical liver disease an

275 (87%) were asymptomatic, detected by routine alanine transaminase (ALT) or HCV monitoring.

276 levels of aspartate aminotransferase (AST), alanine transaminase (ALT), and mitochondrial aspartate

277 MA-IR), uric acid, C-reactive protein (CRP), alanine transaminase (ALT), aspartate transaminase (AST)

278 transaminase 15.0% (95% CI, 13.6%-16.5%) and alanine transaminase 15.0% (95% CI, 13.6%-16.4%).

279 Asymptomatic transient increases in alanine transaminase and aspartate transaminase were obs

280 These markers were predictors of severe alanine transaminase flares, after treatment withdrawal,

281 re not significantly affected; elevations in alanine transaminase occurred in combination with atazan

282 Except for ALT (alanine transaminase), all GRSs were significantly assoc

283 -) mice had elevated liver weights and serum alanine transferase values.

284 These findings reveal alanine transport as a new therapeutic target to enhance

285 Alanine transport was impaired in the cycA mutant, and t

286 eening assay coupled to MS, which identified alanine tRNA synthetase 1 (AARS1) as a direct substrate

287 ctions were associated with reduced rates of alanine turnover, assessed by [3-13C]alanine, in a subgr

288 -) hepatocytes 48 hours after PHx, impairing alanine uptake and, consequently, glucose production.

289 ) 2 and 4 are believed to facilitate hepatic alanine uptake.

290 The NLS residues were mutated to alanine using a type A full-genome cDNA clone, and the v

291 ulosis, in addition to its essential role in alanine utilisation as a nitrogen source.

292 he concentrate-rich diet showed increases in alanine, valerate, propionate, glucose, tyrosine, prolin

293 utoclaved seawater amended with tetrapeptide alanine-valine-phenylalanine-alanine (AVFA), a fragment

294 Separately, kinetic analysis of alanine variants has demonstrated that many of these sam

295 together with substitution of Trp(273) with alanine (W273A), generated an active site mimicking that

296 lactate), and alanine transaminase ([1-(13)C]alanine) was assessed.

297 ruvate-derived molecules such as acetoin and alanine were also increased.

298 Baseline lactate and alanine were associated with baseline and 1-y changes of

299 ation upon substitution of histidine-43 with alanine; whereas x-ray absorption spectroscopy/extended

300 lanines and arginine 229/230 replaced with 2 alanines]) with normal cytoprotective properties, but gr