ライフサイエンスコーパス: aldehyde dehydrogenase

1 s enzyme functions as a long-chain aliphatic aldehyde dehydrogenase.

2 DH, the first model of a membrane-associated aldehyde dehydrogenase.

3 oxidase, and FeaB is a cytosolic NAD-linked aldehyde dehydrogenase.

4 y the kinetic data with NAD+-dependent yeast aldehyde dehydrogenase.

5 , and betaB2-crystallins; alpha-enolase; and aldehyde dehydrogenase.

6 hrome P450s, an alcohol dehydrogenase and an aldehyde dehydrogenase.

7 ) L-lactaldehyde conversion to L-lactate via aldehyde dehydrogenase.

8 ture is conserved across membrane-associated aldehyde dehydrogenases.

9 e and a structural and functional homolog of aldehyde dehydrogenases.

10 sphere assay and flow cytometric analysis of aldehyde dehydrogenase 1 (ALDH1) activity and the CD44(h

11 mor-derived xenografts (PDXs) also expressed aldehyde dehydrogenase 1 (ALDH1) and had a greater capac

12 The role of aldehyde dehydrogenase 1 (ALDH1) as an ovarian cancer st

13 an target these DCIS stem-like cells, reduce aldehyde dehydrogenase 1 (ALDH1) expression, and decreas

14 Aldehyde dehydrogenase 1 (ALDH1) has been suggested as a

15 Accordingly, aldehyde dehydrogenase 1 (ALDH1) was investigated as a p

16 A relatively rare aldehyde dehydrogenase 1 (ALDH1)-positive "stem cell-lik

17 reased activity of stem cell markers such as Aldehyde Dehydrogenase 1 (ALDH1).

18 ancer stem cell associated markers including aldehyde dehydrogenase 1 (ALDH1).

19 Aldehyde dehydrogenase 1 (ALDH1A1)-positive dopaminergic

20 wo subpopulations based on the expression of aldehyde dehydrogenase 1 (ALDH1A1).

21 the role of retinoic acid (RA) production by aldehyde dehydrogenase 1 (Aldh1a1, -a2, and -a3), the ma

22 of CD49f+/CD24- stem-like cells that possess aldehyde dehydrogenase 1 activity.

23 Using a tumor-specific CTL, aldehyde dehydrogenase 1 family member A1 (ALDH1A1) was

24 kinase 1 (DCLK1), CD44 molecule (CD44), and aldehyde dehydrogenase 1 family member A1 (ALDH1A1).

25 on of interferon regulatory factor 8 (IRF-8)/aldehyde dehydrogenase 1 family member A2 (Aldh1a2) and

26 he expression of the RA-synthesizing enzyme, aldehyde dehydrogenase 1 family member A2 (Aldh1a2), sug

27 ts, the expression of the quiescent markers: Aldehyde Dehydrogenase 1 Family Member L1 (ALDH1L1) and

28 glutamate transporter 1 (GLT1), aquaporin-4, aldehyde dehydrogenase 1 family member L1, and other pro

29 d the decreased expression of only one gene, aldehyde dehydrogenase 1 family, member A2 (ALDH1a2), wa

30 Other markers such as aldehyde dehydrogenase 1 family, member L1 (ALDH1L1) sho

31 t a striking enrichment in the expression of aldehyde dehydrogenase 1 isoform A3 (ALDH(+)) as beta ce

32 Aldehyde dehydrogenase 1 L1 and glutamine synthetase wer

33 by amorpha-4,11-diene 12-hydroxylase and/or aldehyde dehydrogenase 1 to artemisinic acid, a precurso

34 The high expression of aldehyde dehydrogenase 1, also known as retinaldehyde de

35 ons in alphaA-crystallin, alphaB-crystallin, aldehyde dehydrogenase 1, betaS-crystallin, betaB2-cryst

36 CD34(+)CD38(-) cells not only highly express aldehyde dehydrogenase 1, but also the RA receptor alpha

37 ression of stem cell surface markers such as aldehyde dehydrogenase 1, side population and by in vitr

38 dication of clonality, was restricted to the aldehyde dehydrogenase 1-positive fraction in MECs but n

39 mine transporter 2, dopamine transporter and aldehyde dehydrogenase 1.

40 demonstrated a novel inducible expression of aldehyde dehydrogenase 1/2 and phospho-STAT3.

41 ) characterized by high levels of CD44v3 and aldehyde dehydrogenase-1 (ALDH1) expression.

42 characterized by a high level of CD44v3 and aldehyde dehydrogenase-1 (ALDH1) expression.

43 ferase omega) and bases/acids (e.g., E269 in aldehyde dehydrogenase-1; D204 in enoyl CoA hydratase-1)

44 Aldehyde dehydrogenase 1A1 (ALDH1A1) activity is used as

45 Aldehyde dehydrogenase 1A1 (ALDH1A1) is a member of a su

46 hydrogenase 11 (Rdh11) mRNA or a decrease in aldehyde dehydrogenase 1a1 (Aldh1a1) mRNA in the liver c

47 Aldehyde dehydrogenase 1A1 (ALDH1A1), a retinoic acid (R

48 ethylation at the promoter of the CSC marker aldehyde dehydrogenase 1A1 (ALDH1A1), stimulating its ge

49 candidate stem cell marker genes, CD133 and aldehyde dehydrogenase 1A1 (ALDH1A1), to be directly reg

50 conserved GABA synthesis pathway mediated by aldehyde dehydrogenase 1a1 (ALDH1a1).

51 enzymes, including alcohol dehydrogenase 1, aldehyde dehydrogenase 1A1, and catalase, as well as the

52 type, expressing IL-10, TGF-beta, IL-27, and aldehyde dehydrogenase 1A2 but not IL-12 or IL-35; IL-10

53 pressing the retinoic acid synthesis enzyme, aldehyde dehydrogenase-1a2, in the ventricle.

54 et al. show that the intracellular levels of aldehyde dehydrogenase 1A3 (ALDH1A3), known as a functio

55 ass of imidazo[1,2-a]pyridine derivatives as aldehyde dehydrogenase 1A3 inhibitors, reporting the evi

56 As the cytosolic enzyme aldehyde dehydrogenase 1A3 turns out to be overexpressed

57 uals with the rs671 SNP in the gene encoding aldehyde dehydrogenase 2 (ALDH2) are at increased risk o

58 roteomic search, we identified mitochondrial aldehyde dehydrogenase 2 (ALDH2) as an enzyme whose acti

59 r a high-frequency deficiency allele for the aldehyde dehydrogenase 2 (ALDH2) enzyme, a critical prot

60 ted with the use of disulfiram (DSF) a known aldehyde dehydrogenase 2 (ALDH2) inhibitor.

61 Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme that el

62 Aldehyde dehydrogenase 2 (ALDH2) is the major enzyme tha

63 Aldehyde dehydrogenase 2 (ALDH2), a key enzyme for detox

64 These include mitochondrial aldehyde dehydrogenase 2 (ALDH2), ATP synthase, acyl-CoA

65 One such mutation is in aldehyde dehydrogenase 2 (ALDH2), denoted ALDH2*2.

66 Aldehyde dehydrogenase 2 (ALDH2), one of 19 ALDH superfa

67 t has recently been shown that mitochondrial aldehyde dehydrogenase 2 (mtALDH) catalyzes the formatio

68 ed Mendelian randomization analysis with the aldehyde dehydrogenase 2 gene (ALDH2) as an instrumental

69 radical scavenger superoxide dismutase 1 and aldehyde dehydrogenase 2 was reduced, whereas the NOX2 (

70 e and extracellular superoxide dismutase and aldehyde dehydrogenase 2 were reduced, whereas the NADPH

71 receptor, activating transcription factor 3, aldehyde dehydrogenase 2, and protein kinase Cdelta.

72 s included those involved in metabolism (eg, aldehyde dehydrogenase 2, ubiquinone biosynthesis protei

73 Here we show that a selective aldehyde dehydrogenase-2 (ALDH-2) inhibitor, ALDH2i, sup

74 Aldehyde dehydrogenase-2 (ALDH2) catalyzes the bioactiva

75 Aldehyde dehydrogenase-2 (ALDH2) catalyzes vascular bioa

76 Aldehyde dehydrogenase-2 (ALDH2) catalyzes vascular bioa

77 hrough systemic transgenic overexpression of aldehyde dehydrogenase-2 (ALDH2) on chronic alcohol inge

78 Aldehyde dehydrogenase-2 levels were unaltered in respon

79 hat both nonenzymatic chemical reactions and aldehyde dehydrogenase-2-mediated enzymatic activity rel

80 duced suppressed activities of mitochondrial aldehyde dehydrogenase, 3-ketoacyl-CoA thiolases, and ad

81 Aldehyde dehydrogenase 3A1 (ALDH3A1) is a NAD(P)+-depend

82 ax6 coding sequences fused downstream of the aldehyde dehydrogenase 3a1 (Aldh3a1) promoter were gener

83 Aldehyde dehydrogenase 3a1 (Aldh3a1) represents approxim

84 decreased Smad3 nuclearization and increased aldehyde dehydrogenase 3A1 expression, with favorable ex

85 ALDH3A1 (aldehyde dehydrogenase 3A1) is abundant in the mouse cor

86 s lines of evidence have shown that ALDH3A1 (aldehyde dehydrogenase 3A1) plays a critical and multifa

87 nd expressed high levels of keratan sulfate, aldehyde dehydrogenase 3A1, and keratocan, molecular mar

88 one reductase, glutathione S-transferase and aldehyde dehydrogenase 3A1.

89 ntensity of Smad7 and the corneal crystallin aldehyde dehydrogenase 3A1.

90 normal myeloid counterparts, depended on the aldehyde dehydrogenase 3a2 (Aldh3a2) enzyme that oxidize

91 Aldehyde dehydrogenase 5A1 (ALDH5A1) which is an enzyme

92 xpression of another metabolic-related gene, aldehyde dehydrogenase 7A1 (ALDH7A1), was validated at t

93 of the REF1 gene revealed that it encodes an aldehyde dehydrogenase, a member of a large class of NAD

94 ooxygenases, two alcohol dehydrogenases, two aldehyde dehydrogenases, a fatty-acid-CoA ligase, a fatt

95 sed cell-surface protein CD90 expression and aldehyde dehydrogenase A1 (ALDHA1) activity, and provide

96 pAADB1 for the overexpression of the alcohol-aldehyde dehydrogenase (aad) gene and downregulation of

97 as glyceraldehyde-3-phosphate dehydrogenase, aldehyde dehydrogenase, aconitase, and FeS cluster-conta

98 Hepatic alcohol dehydrogenase and aldehyde dehydrogenase activities and expression were lo

99 ase activity, whereas the full hydrolase and aldehyde dehydrogenase activities were retained.

100 umbilical cord blood-derived cells with high aldehyde dehydrogenase activity (ALDH(hi)Lin(-)) into ir

101 age depletion and purification based on high aldehyde dehydrogenase activity (ALDH(hi)Lin- cells).

102 Here, we used aldehyde dehydrogenase activity and CD44 expression to s

103 Monocyte-derived AAMs had high levels of aldehyde dehydrogenase activity and promoted the differe

104 (MLN), which correlated with a reduction in aldehyde dehydrogenase activity by SI-derived MLN DCs, a

105 Multipotent epithelial cells with high Aldehyde dehydrogenase activity have been previously rep

106 Aldehyde dehydrogenase activity represents a novel simpl

107 Growth studies indicated that the aldehyde dehydrogenase activity was growth phase depende

108 sion of ALDH1A1 and stem-related genes, high aldehyde dehydrogenase activity, and CD133 positivity.

109 pregulation of pluripotency genes, increased aldehyde dehydrogenase activity, and enhanced expression

110 VEGF increased tumor spheres and aldehyde dehydrogenase activity, both proxies for stem c

111 Slug upregulation, mammosphere formation and aldehyde dehydrogenase activity.

112 ng hypoxia also increased glucose uptake and aldehyde dehydrogenase activity.

113 reased CSC functional properties measured by aldehyde dehydrogenase activity.

114 ion and inducibility by phenobarbital of the aldehyde dehydrogenase activity.

115 here, expression of pluripotency-factors and aldehyde dehydrogenase activity.

116 ng factor and markedly decreased activity of aldehyde dehydrogenase; activity of this enzyme has been

117 uinoline quinone (PQQ)-dependent alcohol and aldehyde dehydrogenase (ADH and AldDH) enzymes for biofu

118 Aldehyde dehydrogenase (Ald) is required for IAA synthes

119 acid burst is dependent on the mitochondrial aldehyde dehydrogenase Ald4p.

120 sphate dehydrogenase (Zwf1p) and a cytosolic aldehyde dehydrogenase (Ald6p).

121 s cells expressing high levels of the enzyme aldehyde dehydrogenase (ALDH bright [ALDH(br)]), along w

122 Breast cancer cells positive for aldehyde dehydrogenase (ALDH(+)) had increased ability t

123 properties (SSC(lo)) and high expression of aldehyde dehydrogenase (ALDH(br)).

124 uman bone marrow (BM) cells purified by high aldehyde dehydrogenase (ALDH(hi)) activity, a progenitor

125 Previously we demonstrated that aldehyde dehydrogenase (ALDH) 1a1 is the major ALDH expr

126 es of cancer stem cells by quantitating both aldehyde dehydrogenase (ALDH) activities and 5 signaling

127 as determined by tumor sphere formation and aldehyde dehydrogenase (ALDH) activity (Aldefluor) assay

128 ers such as melan-A and tyrosinase, enhanced aldehyde dehydrogenase (ALDH) activity and upregulation

129 tain stem-like characteristics, such as high aldehyde dehydrogenase (ALDH) activity due to ALDH1A1 ex

130 Selection of cells positive for aldehyde dehydrogenase (ALDH) activity from a green-fluo

131 High levels of aldehyde dehydrogenase (ALDH) activity have been propose

132 High aldehyde dehydrogenase (ALDH) activity is a marker commo

133 Aldehyde dehydrogenase (ALDH) activity is a reported CSC

134 In this study, we show that aldehyde dehydrogenase (ALDH) activity is indicative of

135 tamoxifen and fulvestrant increased MFE and aldehyde dehydrogenase (ALDH) activity of patient-derive

136 Intermediate (int) levels of aldehyde dehydrogenase (ALDH) activity reliably distingu

137 either sarcosphere generation, chemodrug or aldehyde dehydrogenase (ALDH) activity selection.

138 In this issue of Blood,Gerber et al use aldehyde dehydrogenase (ALDH) activity to further subdiv

139 n this model, human melanoma cells with high aldehyde dehydrogenase (ALDH) activity were enriched 16.

140 nitor cell (LPC) isolation strategy based on aldehyde dehydrogenase (ALDH) activity, a common feature

141 ogenous progenitor cell (EPC) assay based on aldehyde dehydrogenase (ALDH) activity, and to define th

142 roperties of NSCLC cells and increases their aldehyde dehydrogenase (ALDH) activity, which was identi

143 Samples were segregated based on their aldehyde dehydrogenase (ALDH) activity.

144 -)) followed by selection of cells with high aldehyde dehydrogenase (ALDH) activity.

145 The structure shows that the aldehyde dehydrogenase (ALDH) and alcohol dehydrogenase

146 defined by the expression of the CSC markers aldehyde dehydrogenase (ALDH) and CD133.

147 ssays and the expression of stem cell marker aldehyde dehydrogenase (ALDH) as well as by generation o

148 The glycolytic pathway, comprising aldehyde dehydrogenase (ALDH) family genes and in partic

149 The aldehyde dehydrogenase (ALDH) family of metabolic enzyme

150 that VvAHGD and its homologs represent a new aldehyde dehydrogenase (ALDH) family with different subs

151 sions, and all Embryophyta plants possess an aldehyde dehydrogenase (ALDH) gene named ALDH12.

152 between some alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genes and alcohol dependen

153 of both 1,4-dioxane monooxygenase (dxmB) and aldehyde dehydrogenase (aldH) genes.

154 p53 and aldehyde dehydrogenase (ALDH) have been implicated in ke

155 Aldehyde dehydrogenase (ALDH) is a candidate marker for

156 Aldehyde dehydrogenase (ALDH) is an enzyme that is expre

157 Aldehyde dehydrogenase (ALDH) overexpression is characte

158 ism in which alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) play central roles.

159 The aldehyde dehydrogenase (ALDH) superfamily is a vast grou

160 The aldehyde dehydrogenase (ALDH) superfamily member Delta(1

161 The contribution of various isozymes of aldehyde dehydrogenase (ALDH) to the oxidation of LDAs h

162 cancer whose tumors expressed high levels of aldehyde dehydrogenase (ALDH), a detoxifying enzyme char

163 of the colonic epithelial cells positive for aldehyde dehydrogenase (ALDH), a putative marker of prec

164 ificant percentage of MARY-X cells expressed aldehyde dehydrogenase (ALDH), a stem cell marker.

165 Markers such as aldehyde dehydrogenase (ALDH), CD133, and CD44 have been

166 ls catalyzed by alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), flavin-containing monooxy

167 enotype was determined by immunostaining for aldehyde dehydrogenase (ALDH), keratocan, and CD34 and b

168 thiocarbamate sulfoxide metabolite, inhibits aldehyde dehydrogenase (ALDH), leading to accumulation o

169 n to myofibroblasts was identified with anti-aldehyde dehydrogenase (ALDH)-1 and alpha-smooth muscle

170 In this study, we characterized STAT3 in aldehyde dehydrogenase (ALDH)-positive (ALDH(+)) and CD1

171 ibition of the PPARgamma pathway reduces the aldehyde dehydrogenase (ALDH)-positive population in ERB

172 pairs both MS formation and the expansion of aldehyde dehydrogenase (ALDH)-positive population, sugge

173 by expression of the cancer stem-like marker aldehyde dehydrogenase (ALDH).

174 -cell antigen CD27, and the stem cell marker aldehyde dehydrogenase (ALDH).

175 ating the cancer stem-like associated enzyme aldehyde dehydrogenase (ALDH).

176 growth and motility in a RCC cell line, but aldehyde dehydrogenase (ALDH)1 and ALDH7 had no effect.

177 ad increased phosphorylation and activity of aldehyde dehydrogenase (ALDH)2, an enzyme that detoxifie

178 Aldehyde dehydrogenases (ALDH) catalyze the irreversible

179 Aldehyde dehydrogenases (ALDH) participate in multiple m

180 h can be detoxified to carboxyphosphamide by aldehyde dehydrogenases (ALDH), especially ALDH1A1 and A

181 tic mechanism of hydrolytic NAD(P)-dependent aldehyde dehydrogenases (ALDH).

182 n used to identify a mutant of human class 1 aldehyde dehydrogenase (ALDH1) that was no longer inhibi

183 ssion of the ABCG2 transporter and increased aldehyde dehydrogenase (ALDH1), have been associated wit

184 hly up-regulated antioxidant genes including aldehyde dehydrogenases (ALDH1A1 and ALDH1A7), glutathio

185 CD1), nuclear factor kappaB (NF-kappaB), and aldehyde dehydrogenases (ALDH1A1) in CSCs significantly

186 dehydrogenase (RDH11) and cytosolic soluble aldehyde dehydrogenases (ALDH1As) involved in the synthe

187 The common mitochondrial aldehyde dehydrogenase (ALDH2) ALDH2(*)2 polymorphism is

188 The inactive aldehyde dehydrogenase (ALDH2) and the super-active alco

189 Mitochondrial aldehyde dehydrogenase (ALDH2) is the major enzyme that

190 g the inactive variant form of mitochondrial aldehyde dehydrogenase (ALDH2) protects nearly all carri

191 ic attack on propanal in human mitochondrial aldehyde dehydrogenase (ALDH2) yielded an unexpected res

192 E)-hexadecenoic acid by the long-chain fatty aldehyde dehydrogenase ALDH3A2 (also known as FALDH) pri

193 Hepatic cytochromes P450, aldehyde dehydrogenase (ALDH3A2), and 21-hydroxysteroid

194 Aldehyde dehydrogenases (ALDHs) are highly expressed in

195 Aldehyde dehydrogenases (ALDHs) are members of NAD(P)(+)

196 Aldehyde dehydrogenases (ALDHs) catalyze the NAD(P)(+)-d

197 Human aldehyde dehydrogenases (ALDHs) comprise a family of 17

198 Aldehyde dehydrogenases (ALDHs) metabolize reactive alde

199 Cs through Oct-1, a transcription factor for aldehyde dehydrogenases (ALDHs).

200 ansformation catalyzed by monoamine oxidase, aldehyde dehydrogenase and aldehyde reductase.

201 nes, encoding choline dehydrogenase, betaine aldehyde dehydrogenase and choline sulfatase, respective

202 rospectively isolated based on expression of aldehyde dehydrogenase and integrin alpha-6, and that th

203 Cytosolic aldehyde dehydrogenase and keratocan accumulated in the

204 The keratocyte markers aldehyde dehydrogenase and keratocan were maintained aft

205 solated PLCSCs were characterized by markers aldehyde dehydrogenase and keratocan, cultured, and anal

206 Keratocytes normally express high levels of aldehyde dehydrogenase and keratocan.

207 thanol is suppressed by inhibiting CYP2E1 or aldehyde dehydrogenase and requires an elevated NADH/NAD

208 esis, proliferating NK cells did not express aldehyde dehydrogenase and were killed by Cy in vitro.

209 hydratase, its putative reactivating factor, aldehyde dehydrogenase, and ATP cob(I)alamin adenosyltra

210 identified, mitochondrial HMG-CoA synthase, aldehyde dehydrogenase, and catalase as the primary auto

211 iated protein/B12D-related protein1, Betaine aldehyde dehydrogenase, and Unknown protein5.

212 ing ALD6, which encodes an NADP(+)-dependent aldehyde dehydrogenase, and UTR1, which encodes an NAD+

213 Aldehyde dehydrogenases are versatile enzymes that serve

214 dehyde dehydrogenases (Aldhs), also known as aldehyde dehydrogenases, are rate-limiting enzymes that

215 The zRalDH gene encodes an aldehyde dehydrogenase associated with the conversion of

216 disruption and barrier dysfunction, whereas aldehyde dehydrogenase attenuated acetaldehyde-induced t

217 report here high-level expression of betaine aldehyde dehydrogenase (BADH) in cultured cells, roots,

218 d efficacy of autologous bone marrow-derived aldehyde dehydrogenase bright (ALDHbr) cells in patients

219 CSC markers (CD24(+)/CD44(+), CD133(+), and aldehyde dehydrogenase(bright)) from a wide variety of h

220 ma-null (NSgamma) mice with lineage-depleted aldehyde dehydrogenase-bright CD34(+) human cord blood p

221 Aldehyde dehydrogenase-bright cell numbers were inversel

222 Aldehyde dehydrogenase-bright cells expressed CD34 or CD

223 Aldehyde dehydrogenase-bright cells were easily identifi

224 ALD-401 is an enriched population of aldehyde dehydrogenase-bright stem cells, capable of red

225 such aldehydes by oxidation is attributed to aldehyde dehydrogenases but never to aldehyde oxidases.

226 Aldehyde dehydrogenases catalyze the oxidation of aldehy

227 g mammary stem/progenitor markers, including aldehyde dehydrogenase, CD24, CD29, and CD61, we further

228 the known preferential expression of rabbit aldehyde dehydrogenase class 1 (ALDH1A1) in the cornea.

229 er-soluble proteins, transketolase (TKT) and aldehyde dehydrogenase class 1A1 (ALDH1A1), in vivo and

230 ctivating enzyme and, in conjunction with an aldehyde dehydrogenase, converts 1,2-propanediol to prop

231 l hydrolase domain and the carboxyl-terminal aldehyde dehydrogenase domain.

232 the formyl group to CO(2) in the C-terminal aldehyde dehydrogenase domain.

233 tial activities of proline dehydrogenase and aldehyde dehydrogenase domains.

234 purified enzyme identified the latter as an aldehyde dehydrogenase encoded by aldB, which was though

235 ment, controlled in part by an RA-generating aldehyde dehydrogenase encoded by Aldh1a2 (Raldh2) expre

236 t report of the structure of CoA bound to an aldehyde dehydrogenase enzyme and our crystallographic m

237 Here we analyse the kinetics of the aldehyde dehydrogenase enzyme from the fucose/rhamnose u

238 Aldehyde dehydrogenase enzymes irreversibly oxidize alde

239 and allow the efficient action of acylating aldehyde dehydrogenase enzymes to produce an acyl-CoA th

240 and mitochondria, making it unique among the aldehyde dehydrogenase enzymes.

241 distinguish the acylating from non-acylating aldehyde dehydrogenase enzymes.

242 In conclusion, ALDH7A1 is a novel aldehyde dehydrogenase expressed in multiple subcellular

243 d in a cellular hierarchy in which primitive aldehyde dehydrogenase expressing mesenchymal cells regu

244 ances mammosphere formation, and upregulates aldehyde dehydrogenase expression and activity.

245 of a fatty alcohol oxidase (FAO) and a fatty aldehyde dehydrogenase (FADH) before they can be beta-ox

246 in the gene coding for membrane-bound fatty aldehyde dehydrogenase (FALDH) lead to toxic accumulatio

247 The aldehyde dehydrogenase family 1 member A3 (ALDH1A3) cata

248 was associated with increased expression of aldehyde dehydrogenase family 1 subfamily A1 (Aldh1a1).

249 ession of the retinoic acid-producing enzyme aldehyde dehydrogenase family 1, subfamily A2 (ALDH1A2)

250 s the retinoic acid (RA)-synthesizing enzyme aldehyde dehydrogenase family 1, subfamily A2 (ALDH1a2)

251 Cs synergistically induced the expression of aldehyde dehydrogenase family 1, subfamily A2, a rate-li

252 and RA receptor beta play important roles in aldehyde dehydrogenase family 1, subfamily A2, induction

253 ); and oxidation of retinaldehyde into RA by aldehyde dehydrogenases family 1, subfamily A (ALDH1as),

254 the monoamine oxidase TynA and the aromatic aldehyde dehydrogenase FeaB.

255 the tyramine oxidase, TynA, and the aromatic aldehyde dehydrogenase, FeaB, whose respective activitie

256 yet the origin and evolution of the betaine aldehyde dehydrogenase gene (BADH2) underlying this trai

257 include overexpression of the mitochondrial aldehyde dehydrogenase gene ALD5 or disruption of the re

258 ay for MICs) and decreased the percentage of aldehyde dehydrogenase (high) cells (a marker of MICs) i

259 of a Cys302Ser mutant of human mitochondrial aldehyde dehydrogenase in binary complexes with NAD(+) a

260 The mitochondrially localized aldehyde dehydrogenase in D. melanogaster has two import

261 elial cells with the increased expression of aldehyde dehydrogenase in sporadic colon cancer correlat

262 ly established cancer stem cell marker ALDH (aldehyde dehydrogenase) in the maintenance of this drug-

263 olic alcohol dehydrogenase and mitochondrial aldehyde dehydrogenase, in part determine blood alcohol

264 , attenuated GS-DHN levels and cyanamide, an aldehyde dehydrogenase inhibitor, decreased formation of

265 ydrogenase knockout (Rdh12(-/-)) mice and by aldehyde dehydrogenase inhibitors.

266 apable of binding copper and an inhibitor of aldehyde dehydrogenase, is currently being used clinical

267 nzyme A acetyltransferase (AtoB), a probable aldehyde dehydrogenase (KauB), ribosomal protein L25 (Rp

268 ur high-resolution crystal structures of the aldehyde dehydrogenase lead to a revised reaction mechan

269 ) pathways; 4) increased side population and aldehyde dehydrogenase levels; and 5) increased expressi

270 ine compounds, we propose that an additional aldehyde-dehydrogenase-mediated step is required to make

271 lls, thus proving the concept that targeting aldehyde dehydrogenase might represent a novel and promi

272 ted by genetic deletion of the mitochondrial aldehyde dehydrogenase (mtALDH).

273 al difference between this protein and other aldehyde dehydrogenases of the same enzyme superfamily;

274 creasing research interest, considering that aldehyde dehydrogenases overexpression is characteristic

275 The leaders of yeast aldehyde dehydrogenase (pALDH) and malate dehydrogenase

276 By using the Aldefluor assay, aldehyde dehydrogenase-positive (ALDH+) cells comprised

277 utputs are similarly distributed between the aldehyde dehydrogenase-positive and -negative subsets of

278 y showing that a BCL11A peptide can decrease aldehyde dehydrogenase-positive BCSCs and mammosphere fo

279 with a lack of CD38 expression and contained aldehyde dehydrogenase-positive cells as well as cells w

280 growth in BMSC-adherent myeloma cell lines, aldehyde dehydrogenase-positive MM cancer stem cells and

281 represents the first crystal structure of an aldehyde dehydrogenase-product complex.

282 ct of Mg2+ ions on human liver mitochondrial aldehyde dehydrogenase revealed that the bacterial enzym

283 h as the spinach (Spinacia oleracea) betaine aldehyde dehydrogenase (SoBADH), efficiently oxidize bet

284 derstanding the evolution of the prokaryotic aldehyde dehydrogenase superfamily and their diversity o

285 ization flap, which is unprecedented for the aldehyde dehydrogenase superfamily.

286 decarboxylases and screening for promiscuous aldehyde dehydrogenases, synthetic pathways were constru

287 zymatic (anchoring sequentially both ADH and aldehyde dehydrogenase) systems were tested.

288 rogenase (P5CDH; also known as ALDH4A1), the aldehyde dehydrogenase that catalyzes the oxidation of g

289 PuuC is a nonspecific aldehyde dehydrogenase that oxidizes all the aldehydes i

290 drogenase II is disordered, whereas in other aldehyde dehydrogenases this region forms a well defined

291 e alcohol, such as alcohol dehydrogenase and aldehyde dehydrogenase; those associated with disinhibit

292 est, we tested a small-molecule activator of aldehyde dehydrogenase type 2, Alda-1, which reduced oxi

293 s that an equilibrium coupled to the enzyme, aldehyde dehydrogenase type 2, prevents the accumulation

294 Activation and inhibition of mitochondrial aldehyde dehydrogenase type-2 (ALDH2) also mimicked and

295 Aldehyde dehydrogenase typically performs oxidation of a

296 Metabolism of 3-AP to beta-alanine by aldehyde dehydrogenase was also evaluated in retinal gan

297 An aldehyde dehydrogenase was detected in crude cell extrac

298 Alcohol and aldehyde dehydrogenases were expressed and active in myo

299 By contrast, inhibition of aldehyde dehydrogenase with phenethyl isothiocyanate inc

300 ion than the mRNA for retinaldehyde-specific aldehyde dehydrogenase (zRalDH), a retinoic acid-synthes