ライフサイエンスコーパス: aldimine

1 complexes, cysteinyl aldimine and glutaminyl aldimine.

2 s-313 to generate the product-bound external aldimine.

3 og trapped in the active site as an external aldimine.

4 tures of the ASL complexes with the internal aldimine.

5 ity that is not associated with the internal aldimine.

6 e-258 than the deprotonation of the external aldimine.

7 han preservation of the fate of the external aldimine.

8 crylate without accumulation of the external aldimine.

9 ovided by the lysine that forms the internal aldimine.

10 f the glycine pro-R proton from the external aldimine.

11 nting the formation of the L-serine external aldimine.

12 mined spectrophotometric pKa of the internal aldimine.

13 ximately 20 degrees relative to the internal aldimine.

14 reaction after the formation of the external aldimine.

15 ate results in the formation of the external aldimine.

16 hydrogen bonding with the sulfhydryl of Cys-aldimine.

17 nal aldimine with the PLP-substrate external aldimine.

18 0.6 +/- 3.8 s(-1) and re-formed the internal aldimine.

19 racemic donor-acceptor cyclopropanes and (E)-aldimines.

20 use of o-thiomethyl-p-methoxyaniline-derived aldimines.

21 t at room temperature with aldehydes to give aldimines.

22 nation precatalyst of diphenylacetylene with aldimines.

23 broad substrate range including nonaromatic aldimines.

24 hons for enantioselective additions to N-Boc-aldimines.

25 ative to the classical methods for preparing aldimines.

26 e reactions, especially for the synthesis of aldimines.

27 nozinc reagents to a variety of alpha-chloro aldimines.

28 d aryl organometallic reagents to N-sulfinyl aldimines 1 and 2 and ketimines 5 and 6.

29 wide range of N-p-(methoxy)phenyl protected aldimines 3 derived from alkyl, aryl, and heteroaryl ald

30 tepwise reaction by formation of an external aldimine adduct with the PLP cofactor.

31 ononitrile and diphenylphosphinoyl-protected aldimine affording products in high yields (up to 98%) a

32 uent radical-radical coupling with secondary aldimines affords a variety of beta-amino ether products

33 ated between the alpha-site and the external aldimine, alpha-aminoacrylate, and quinonoid forms of th

34 Allylboration of cyclic aldimines also proceeded to give allylated products in g

35 favors this form in its equilibrium with Ala aldimine and Ala ketimine.

36 bind to the allosteric site in the internal aldimine and alpha-aminoacrylate external aldimine forms

37 the rates of the interconversion of external aldimine and aminoacrylate intermediates in the Tryptoph

38 sition state for interconversion of external aldimine and aminoacrylate intermediates in the Tryptoph

39 and approximately 340 nm, is assigned as Cys aldimine and Cys ketimine forms in rapid equilibrium.

40 ed H123A and C364A SufS variants to trap Cys-aldimine and Cys-ketimine intermediates of the cysteine

41 DAB, and 2,3-DAPr bind to PLP as an external aldimine and elicit the AdoCbl Co-C bond homolysis and t

42 rming external aldimine complexes, cysteinyl aldimine and glutaminyl aldimine.

43 te interconversion at the stages of external aldimine and ketimine formation.

44 enzyme and for the stability of the external aldimine and ketimine intermediates.

45 Under similar conditions, aldimine and ketimine produced oxaziridines.

46 ed for Schiff base formation in the internal aldimine and later as a general base.

47 give, as in solution, a mixture of external aldimine and quinonoid intermediates and gem-diamine and

48 l-Met and l-Phe to form mixtures of external aldimine and quinonoid intermediates as in solution.

49 s to form equilibrating mixtures of external aldimine and quinonoid intermediates in rapid-scanning s

50 c evidence for the formation of the external aldimine and quinonoid intermediates in the reactions of

51 rosine form equilibrium mixtures of external aldimine and quinonoid intermediates when they bind to T

52 e to form equilibrating mixtures of external aldimine and quinonoid intermediates, absorbing at appro

53 s to form equilibrating mixtures of external aldimine and quinonoid intermediates, similar to those o

54 , to form equilibrating mixtures of external aldimine and quinonoid intermediates.

55 ) gives an equilibrating mixture of external aldimine and quinonoid species, E(Aex)(his) and E(Q)(his

56 x with PMP alone as well as the PLP internal aldimine and show that the dimeric structure of WbpE obs

57 ligned with the p orbitals of the conjugated aldimine and thus maximizes stereoelectronic effects.

58 ned to the endocyclic proton of the internal aldimine and to the bridging hydrogen bond, respectively

59 ect to the (hetero)aromatic aldehyde-derived aldimine and tolerates significant variability of the di

60 cycloaddition reaction between N-(3-pyridyl)aldimines and acetylenes where 1,5-naphthyridines are ob

61 d, starting from N-protected trifluoromethyl aldimines and cyclic or acyclic beta-keto esters bearing

62 h formal [2 + 2] cycloadditions with N-tosyl aldimines and formal [4 + 2] cycloadditions with either

63 ant, suggested rapid equilibrium of isomeric aldimines and geminal diamines.

64 ve for amine dehydrogenation to give N-alkyl aldimines and H(2).

65 tert-Butanesulfinyl aldimines and ketimines bearing an alpha-benzyloxy or al

66 s been designed and synthesized; its derived aldimines and ketimines have been applied for asymmetric

67 amides provide stable bicyclic and tricyclic aldimines and ketimines in good yields.

68 reaction of substituted donors with N-tosyl aldimines and ketimines in high regio-, diastereo-, and

69 Pr)(3) ester enolates to tert-butanesulfinyl aldimines and ketimines provided beta-substituted, alpha

70 alkynes and alpha,beta-unsaturated N-benzyl aldimines and ketimines that proceeds through dihydropyr

71 gh diastereoselectivity to chiral N-sulfinyl aldimines and ketimines to provide alpha-amino amides.

72 for aromatic, heteroaromatic, and aliphatic aldimines and ketimines using ethyl cyanoformate as the

73 The catalyst has a large scope, can reduce aldimines and ketimines, and tolerates a variety of func

74 ntioselective for the addition of cyanide to aldimines and ketimines.

75 to be effective in addition to both N-tosyl aldimines and N-tolyl sulfinimines, the latter reaction

76 elective addition of alkylazaarenes to N-Boc aldimines and nitroalkenes under mild conditions.

77 PLP is covalently bound via an internal aldimine, and residues from both domains and both subuni

78 e Grignard addition to a tert-butanesulfinyl aldimine, and ring closing olefin metathesis as key step

79 Furthermore, this aldimine appears to be inappropriately aligned for effic

80 Aziridination of N-tosyl aldimines applying modified hydroxylamine under asymmetr

81 nserved, yet the pK(a)'s of the two internal aldimines are 9.3 and 7.0, respectively, to complement t

82 n of a broad range of carbonyl compounds and aldimines are disclosed.

83 A variety of aryl and aliphatic N-Boc-aldimines are effective substrates for this transformati

84 Catalytic allylboron additions to aldimines are presented for which small amounts of Zn(OM

85 esonance-stabilized structure of the PLP-Ser aldimine as seen in aminotransferases.

86 to the unprotonated tautomer of the external aldimine as well as the appearance of a new fluorescent

87 a broad range of trifluoromethyl imines and aldimines as nucleophiles to engage in chemo-, regio-, d

88 product UDP-GlcNAc(3NH(2))A as the external aldimine at 1.9 A resolution.

89 also be used for catalytic hydrogenation of aldimines at room temperature via a frustrated Lewis pai

90 els-Alder reactions of the alkyl-substituted aldimines bearing the structurally modified N-aryl unit

91 Four prototropic isomers of a model aldimine between AIB and 5'-deoxypyridoxal, with acetate

92 In the resting enzyme, an internal aldimine between PLP and an essential lysine in the acti

93 The internal aldimine between pyridoxal 5'-phosphate and the epsilon-

94 Since the internal aldimine bond between the protein lysine, Lys33, and C4'

95 alently bound to the protein via an internal aldimine bond with Lys42.

96 system between the PLP ring and the internal aldimine bond.

97 on with ethylenediamine and reduction of the aldimine bonds formed.

98 are strengthened in the presence of external aldimines bound to the beta-site.

99 th PLP, shows slow formation of the external aldimine but does not form the alpha-aminoacrylate inter

100 ample, from additions to protected/activated aldimines), but those involving ketimines are much less

101 erates both tautomeric forms of the external aldimine, but with D-ornithine the equilibrium is shifte

102 gests that the chemical fate of the external aldimine can be redirected by modifications at the N-ter

103 The overall transformation from amines to aldimines can be conveniently performed by a sequential

104 ive Mannich-type reaction of azlactones with aldimines catalyzed by a chiral phosphoric acid is descr

105 h reaction of diazoacetate esters with N-Boc aldimines catalyzed by silver(I) triflate in the presenc

106 lts, which possibly stabilize the protonated aldimine coenzyme complex.

107 on of the Tryptophan synthase L-Ser external aldimine complex at 495 nm, with 420 nm excitation, prov

108 with the substrate, and its product external aldimine complex have been determined at 1.46, 1.8, and

109 for the adsorption complex and the external aldimine complex of the enzyme with the substrate.

110 by motion of the l-Trp indole moiety of the aldimine complex, contributes to quinonoid intermediate

111 Crystal structures of the internal aldimine complexed with G3P and with three of the new AS

112 with cysteine or glutamine forming external aldimine complexes, cysteinyl aldimine and glutaminyl al

113 ria between different quinonoid and external aldimine complexes.

114 le previously reported internal and external aldimine complexes.

115 The synthesis features the use of an enolate-aldimine condensation between a chiral glycine aluminum

116 mes were firstly captured by latex beads via aldimine condensation, followed by bio-recognition using

117 Cyclization of aromatic ketimines and aldimines containing alkenyl groups tethered at the meta

118 ene to alpha-ketoesters or N-benzenesulfonyl aldimines corroborate a catalytic mechanism involving C

119 Aldimine coupling (AIC) is the nitrogen analogue of the

120 Cyanide-catalyzed aldimine coupling was employed to synthesize compounds w

121 ydroxylation was shown to alter the divalent aldimine cross-link chemistry of mutant skin collagen.

122 uman breast cancer cells were embedded in 3D aldimine cross-linked collagen matrices and used as an i

123 equent reaction with hydrogen-bond-activated aldimines delivers beta-aminocarbonyl compounds with hig

124 mbination of these effects leads to a stable aldimine derivative and potent inactivation of alanine r

125 reacted with optically pure trifluoromethyl aldimine derived from (R)-alpha-methylbenzylamine, givin

126 a wide range of N-p-methoxyphenyl-protected aldimines, derived from alkyl, aryl and heteroaryl aldeh

127 As expected, BAPN inhibited the formation of aldimine-derived cross-links in collagen, and the constr

128 Borohydride reduction of the native enzymic aldimines did not increase the denaturation temperature

129 ) chloride and sulfate increase the external aldimine dissociation constants for O-acetyl-L-serine, L

130 t, formation of the L-Ser and L-Trp external aldimines E(Aex1) and E(Aex2) at the beta-site causes a

131 ), which converts to the alpha-aminoacrylate aldimine, E(A-A).

132 nts for the conversion of the L-Ser external aldimine, E(Aex1), to E(A-A) show that the primary kinet

133 In stage I, l-Ser forms an external aldimine, E(Aex1), which converts to the alpha-aminoacry

134 be the allosteric properties of the internal aldimine, E(Ain).

135 (gamma-thialysine) or external (ethylamine) aldimine followed by the slow formation of the alpha-ami

136 mplex and the pyridoxal 5'-phosphate-glycine aldimine, followed by the abstraction of the glycine pro

137 Cys-364 is essential for positioning the Cys-aldimine for Calpha deprotonation, His-123 acts to proto

138 posits two parallel pathways to the external aldimine for this mutant, the minor one has the alpha-am

139 brium isotope effect ((2)H-EIE) favoring the aldimine form (417 nm) is observed in the second state p

140 structure of NtdA alone reveals the internal aldimine form of NtdA with the cofactor pyridoxal phosph

141 udies of the ASL complexes with the internal aldimine form of the enzyme establish the following.

142 ydryl group of the substrate on the internal aldimine form of the pyridoxal 5'-phosphate (PLP) cofact

143 sopropylamine, and glycine all have external aldimine formation as the rapid observable step, based o

144 ocyclohexane-1-carboxylate may have external aldimine formation as the rate-determining step.

145 rientation of the PLP cofactor upon external aldimine formation is impeded in H282A.

146 l-2-aminomalonate, indicating rapid external aldimine formation on this longer time scale.

147 anism (observed as a lag in the ALA external aldimine formation progress curve), consistent with conf

148 isotope effects were found for the external aldimine formation steps in both the L --> D (1.13 +/- 0

149 The spectral data indicate that external aldimine formation with either AIB or L-alanine and DGD-

150 the progress curve for the L-serine external aldimine formation, indicating a hysteretic behavior in

151 ted in the T148A-catalyzed L-serine external aldimine formation.

152 We show here that the external aldimine formed between PLP and GABA is apparently respo

153 arrangement mechanism, in which the external aldimine formed between PLP and lysine is initially conv

154 um changes characteristic of reduction of an aldimine formed between PLP and lysine.

155 situ generation and trapping of the reactive aldimine formed from urea and aldehyde by the diene syst

156 pH titration of the external aldimine formed with ALA indicated the D279E mutation in

157 In the second monomer, the external aldimine formed with the substrate analog.

158 NMR experiments on isotopically labeled PLP aldimines formed by lyophilization with poly-L-lysine.

159 The external aldimines formed upon addition of L-Ala or L-Ser are sta

160 al aldimine and alpha-aminoacrylate external aldimine forms of OASS; (iv) sulfate also binds to the a

161 cient biomimetic method for the synthesis of aldimines from aldehydes and compounds bearing the NH2 g

162 p process involving the initial formation of aldimines from the corresponding aldehydes and 2-amino b

163 range of heteroaromatic and simple aliphatic aldimines gave anti-rich (approximately 3-19:1) beta-nit

164 (dimethylamino)vinyl]-1,3-dimethyluracil and aldimines has been developed for the construction of dih

165 xal 5'-phosphate (PLP) linked as an internal aldimine in alanine racemase (AlaR), aspartate aminotran

166 orption and emission spectra of the internal aldimine in the absence and presence of the product acet

167 The holo-SDH contained PLP-OMS aldimine in the active site, indicating that OMS can for

168 methionine covalently linked as an external aldimine in the active site.

169 n of the roles of aryl nitromethane and aryl aldimine in the key step, which revealed unique substrat

170 hile it is more similar to the open external aldimine in the presence of NH4(+).

171 ormation of the geminal diamine and external aldimine in this pathway were determined to be 25 and 4

172 e of aryl, heteroaryl, vinyl, or cyclopropyl aldimines in high yield and with excellent diastereo- (u

173 adical rearrangement by forming a lysine-PLP aldimine, in which the imine group participates in the i

174 Mannich (VM) reactions of alkyl-substituted aldimines (including those bearing heteroatom-containing

175 formation (386 s-1 at 0.1 M) of an external aldimine intermediate absorbing at 420 nm, followed by s

176 e aminotransferase to give a stable external aldimine intermediate are reported.

177 e, and decanoyl-CoA shows a trapped external aldimine intermediate, suggesting that the condensation

178 ic orientation about C alpha in the external aldimine intermediate.

179 demonstrates that formation of the external aldimine intermediates and abstraction of the C alpha pr

180 rt a stepwise racemization of stereoisomeric aldimine intermediates in which a substrate-based carban

181 ble that stereoisomerization of the external aldimine intermediates occurs through a concerted double

182 in of V241 facilitates formation of external aldimine intermediates with primary amine substrates, wh

183 d intermediates and gem-diamine and external aldimine intermediates, respectively.

184 on of N-telopeptide allysine aldol dimers in aldimine intermolecular linkage to nonglycosylated alpha

185 h accelerates the conversion of the external aldimine into the initial quinonoid intermediate.

186 e binding of L-allothreonine as the external aldimine is faster than formation of the 3-methyl aminoa

187 d by a slower reaction in which the internal aldimine is protonated on the Schiff base N.

188 bsorption spectra indicate that the external aldimine is the predominant L-serine intermediate and th

189 antioselective addition of an allene unit to aldimines is disclosed.

190 lkylation of indole and its derivatives with aldimines is efficiently catalyzed by a zinc-ProPhenol d

191 od for the enantioselective cinnamylation of aldimines is reported.

192 ogue onto PLP (i.e. formation of an external aldimine) is also rapid (532 s(-1), D-ornithine; 488 s(-

193 We infer that these represent the internal aldimine (lambda(max) 416 nm; A), two different unligand

194 a(max) at 409 nm; B and C), and the external aldimine (lambda(max) 426 nm; D).

195 the substrate Calpha-H bond in the external aldimine lies between those of the two catalytic bases,

196 The PLP forms an internal aldimine link to the Rossmann domain through Lys(629), e

197 The data indicate that the formation of the aldimine linkage between lysine 346 and PLP is important

198 his is characteristic of the reduction of an aldimine linkage between the carbonyl group of PLP and t

199 scopy with HemA suggested the presence of an aldimine linkage between the enzyme and pyridoxal 5'-pho

200 n a pyridoxal 5'-phosphate (PLP) molecule in aldimine linkage to Lys39 as a protonated Schiff base, a

201 /beta barrel and is covalently linked via an aldimine linkage to Lys39, which is at the C-terminus of

202 radical rearrangement by forming an external aldimine linkage with the epsilon-amino group of a subst

203 amides by intramolecular ring closure of the aldimine moieties with the carboxamide group elicited by

204 ex with the reduced analogue of the external aldimine, N-(5'-phosphopyridoxyl)-d-alanine (PPDA).

205 the phenolic oxygen (enolimine form) to the aldimine nitrogen (ketoenamine form) is often considered

206 7.7) from a form with a protonated internal aldimine nitrogen (lambdamax = 416 nm) to a deprotonated

207 phosphate, reducing the pKa of the internal aldimine nitrogen and promoting formation of quinonoid i

208 trols kcat/KAIB, is not deprotonation of the aldimine nitrogen.

209 l-depleted enzyme, formation of the external aldimine occurs over long time scales (approximately 50

210 ional change induced by the formation of the aldimine of 4-aminocyclopentane-1,3-dicarboxylic acid an

211 mM) decrease the proportion of the external aldimine of aminoacrylate and induce formation of the qu

212 We find that the gem-diamine and external aldimine of aminoacrylate are the primary intermediates

213 reaction with L-serine and that the external aldimine of aminoacrylate or its complex with L-homocyst

214 n the absence of L-homocysteine produced the aldimine of aminoacrylate, which absorbed at 460 nm and

215 and decreases the proportion of the external aldimine of aminoacrylate.

216 ies, which has been assigned as the external aldimine of cystathionine.

217 The internal aldimine of eCGS remains protonated at pH <10.5, and the

218 hase gives an H(+) release when the external aldimine of L-Ser, E(Aex(1)), is converted to E(A-A).

219 nol increases the proportion of the external aldimine of L-serine and decreases the proportion of the

220 inding that the nonionic urea stabilizes the aldimine of L-serine in the presence, but not in the abs

221 dence (1) that the formation of the external aldimine of L-serine is faster than the formation of the

222 mer of the enzyme that predominates when the aldimine of L-serine is formed and shift the equilibrium

223 mer of the enzyme that predominates when the aldimine of L-serine is formed and shifts the equilibriu

224 and increase the proportion of the external aldimine of L-serine.

225 oid intermediate formation from the external aldimine of l-Trp can be estimated to be -26.5 mL/mol, a

226 ogen-bonded ionic contacts hold the external aldimine of PLP and L-alpha-lysine in position for abstr

227 ction, we observed formation of the external aldimine of serine (14 mm(-1) s(-1)) and the aminoacryla

228 intermediate covalently attacks the internal aldimine of the enzyme.

229 sm for TPL involves formation of an external aldimine of the substrate, followed by deprotonation of

230 The internal aldimine of ytCBS remains protonated at pH < 11; therefo

231 hout detectable accumulation of the external aldimine or other intermediates.

232 ic studies suggest that isomerization of the aldimine or resultant iminium to the Z geometry is not a

233 m optically pure N-protected trifluoromethyl aldimines or directly from N-alpha-amino ester trifluoro

234 -OSHS) versus pH profiles can be assigned to aldimine, or to L-OSHS prototropy.

235 he C-P bonds make with the p orbitals of the aldimine pi system are correlated with the reactivities

236 ynthase to close this distance increases the aldimine pK(a) from 9.3 to 10.0, as would be predicted f

237 retro mutation A224I into AATase raised the aldimine pK(a) of that enzyme from 6.96 to 7.16 and resu

238 g 1.1 unit decrease (from 9.3 to 8.2) in the aldimine pK(a), thus identifying Ile232 as a major deter

239 of the succinyl-CoA substrate, the external aldimine predominates over the glycine quinonoid interme

240 aromatic and aliphatic N-tert-butanesulfinyl aldimines proceeds in good yields (up to 97%) and with v

241 ta support the irreversible formation of the aldimine product in marked contrast with traditional met

242 with a range of aldehydes to give bidentate aldimine proligands L.

243 Borohydride reduction of the aldimine promotes an accompanying base-catalyzed Michael

244 methyl acetate, to the N-tert-butanesulfinyl aldimines provides 1,2-disubstituted beta-amino alcohols

245 ization of a range of aromatic ketimines and aldimines provides bi- and tricyclic ring systems with g

246 Its assignment as Ala aldimine, quinonoid, and ketimine forms in rapid equilib

247 Aldimines react with aryl- and hetarylacetylenes in the

248 he active site lysine and the other with the aldimine reduced to a secondary amine.

249 tive coupling of alcohols and amines to form aldimines represents an environmentally benign methodolo

250 by comparable amounts of the L-Ser external aldimine Schiff base, E(Aex1), and the alpha-aminoacryla

251 to a lysine residue (Lys265) as an internal aldimine/Schiff base and the active site is composed of

252 An assortment of aldimines serve as suitable substrates.

253 tly from N-alpha-amino ester trifluoromethyl aldimines, small psi[CH(CF3)NH]-peptidomimetic backbones

254 Na(+) binding stabilizes the l-Ser external aldimine species, E(Aex(1)).

255 reaction of l-Ser with the MVC-free internal aldimine species, E(Ain), initially gives small amounts

256 in the resting holoenzyme form, the internal aldimine state of tryptophan synthase.

257 Comparison of the l-Ser external aldimine structures of both native and N100Y reveals sig

258 stereoselectivities (>96:2) for a variety of aldimine substrates.

259 ible with stabilization of the GABA external aldimine suggest that a GabR aminotransferase-like activ

260 ociated with Schiff base formation, ketimine/aldimine tautomerization, and transimidation etc.

261 -Cys gives a tautomeric form of the external aldimine that absorbs at 330 nm, and is also seen in the

262 e of PLP and l-threonine reveals an external aldimine that has lost the l-threonine side chain.

263 mase because, upon formation of the external aldimine, the phosphonate group interacts with putative

264 ransfer hydrogenation and hydrosilylation of aldimines through amine-boranes and silanes, respectivel

265 rms: one with the PLP covalently bound as an aldimine to the Nepsilon-amino group of the active site

266 , which must rearrange to a 2-aminocrotonate aldimine to yield final products.

267 re diastereoselective additions to aldehydes/aldimines to access homoallylic alcohols/amines containi

268 ate 2 undergo 1,2-addition with a variety of aldimines to afford the corresponding secondary sulfonam

269 the addition of phosphites to aldehydes and aldimines to give enantioenriched alpha-hydroxy and alph

270 enzyme steers the breakdown of the external aldimine toward decarboxylation instead of amino transfe

271 addition of acetylacetone to N-Boc protected aldimines Type I E and Type II E are active.

272 ituted o-thiomethyl-p-methoxyaniline-derived aldimines undergo Ag-catalyzed enantioselective VM react

273 one-derived titanium enolate and an aromatic aldimine was found to occur only after introduction of a

274 thyl nitroacetate on N-alkyl trifluoromethyl aldimines was reported to synthesize beta-amino alpha-ni

275 zed addition reactions of arylboroxines with aldimines were also realized.

276 L-tyrosine resulted in formation of external aldimine, which absorbed at 420 nm, and a very small abs

277 bsorption of the 423 nm band of the external aldimine, which is a characteristic of the open conforma

278 (pinacolato)diboron to N-tert-butanesulfinyl aldimines, which proceeds in good yields (52-88%) and wi

279 one monomer, the PLP remained as an internal aldimine with a deprotonated Schiff base.

280 The formation of an external aldimine with aspartic acid at pH 9 also produces the ke

281 e of the product acetate and of the external aldimine with l-serine.

282 The inactive enzyme is an aldimine with lambda(max) of 432 nm.

283 K42A-OASS is isolated as an external aldimine with methionine or leucine and shows no reactio

284 Myriocin initially forms an external aldimine with PLP at the active site, and a structure of

285 tion activation via formation of an external aldimine with PLP.

286 inding to SufS and formation of the external aldimine with pyridoxal phosphate required for early ste

287 L-Ala-P forms an external aldimine with the bound pyridoxal 5'-phosphate (PLP) cof

288 saldimination of the PLP-Lys144beta internal aldimine with the PLP-substrate external aldimine.

289 eta subunit Lys(87), which forms an internal aldimine with the pyridoxal phosphate and catalyzes the

290 he complex, L-serine forms a stable external aldimine with the pyridoxal phosphate coenzyme at the ac

291 ymmetric cycloaddition of o-hydroxy aromatic aldimines with 3-substituted coumarins.

292 tion of in situ generated heterocyclic azine-aldimines with B-keto sulfoxonium ylides has been develo

293 The reaction of chiral N-tert-butanesulfinyl aldimines with beta-keto acids under basic conditions at

294 for the preparation of a variety of sulfinyl aldimines with excellent yields and purities in only 10

295 h reactions between glycine imines and N-Boc-aldimines with high levels of enantio- and diastereocont

296 ulfate prevent the formation of the external aldimines with L-cysteine or L-serine; (ii) chloride and

297 The mechanism of reaction of N-(3-pyridyl)aldimines with olefins can be explained by an asynchrono

298 Structures of the external aldimines with substrate/product reveal a pair of histid

299 scopes that can catalyze both aldehydes and aldimines with such high selectivity and no reports util

300 nit, in which both amino acids form external aldimines with the coenzyme, pyridoxal phosphate.