ライフサイエンスコーパス: aldo-keto reductase

1 ycin A catalyzed by Aln4, an NADPH-dependent aldo-keto reductase.

2 a dimeric aldo-keto reductase or a family 2 aldo-keto reductase.

3 ing pocket that is more polar than a typical aldo-keto reductase.

4 ient binding of glutathione conjugates to an aldo-keto reductase.

5 glutamate-cysteine ligase modifier subunit, aldo-keto reductases-1-C1 and -C2, and IL-8.

6 nt from bacteria to mammals, and we identify aldo-keto reductase 1A1 as the mammalian functional anal

7 Aldo-keto reductase 1B10 (AKR1B10) is a human enzyme tha

8 Aldo-keto reductase 1B10 (AKR1B10) protein is a new tumo

9 show that FXR induces expression of Akr1b7 (aldo-keto reductase 1b7) in murine small intestine, colo

10 Human aldo-keto reductases 1C1-1C4 (AKR1C1-AKR1C4) function in

11 Aldo-keto reductase 1C3 (AKR1C3) catalyzes the synthesis

12 Type 5 17beta-hydroxysteroid dehydrogenase, aldo-keto reductase 1C3 (AKR1C3) converts Delta(4)-andro

13 To investigate aldo-keto reductase 1C3 (AKR1C3) expression in T and B a

14 Aldo-keto reductase 1C3 (AKR1C3) has been shown to media

15 Aldo-keto reductase 1C3 (AKR1C3) is a key enzyme in the

16 Aldo-keto reductase 1C3 (AKR1C3) is overexpressed in cas

17 linical characteristics (for cases), and the aldo-keto reductase 1C3 (AKR1C3) rs12529 genetic polymor

18 ke AR-V7, and steroidogenic enzymes, such as aldo-keto reductase 1C3 (AKR1C3), to overcome drug resis

19 Aldo-keto reductase 1C3 (AKR1C3; type 5 17beta-hydroxyst

20 cells, PR-104A is independently activated by aldo-keto-reductase 1C3 (AKR1C3).

21 Human aldo-keto reductase 1D1 (AKR1D1) and AKR1C enzymes are e

22 AKR1D1 (aldo-keto reductase 1D1) is the only known human enzyme

23 template for the homology modeling of other aldo/keto-reductase 4 family members, including the redu

24 o (i) delineate a maize gene family encoding aldo keto reductase-4s (AKR4s) (ii) help bridge sequence

25 d (2) it expresses alcohol dehydrogenase and aldo-keto reductase activity native to AdhD from Pyrococ

26 plasmically exposed beta-subunits(1-5) whose aldo-keto reductase activity(6-8) is required for the ho

27 pe 3 3alpha-hydroxysteroid dehydrogenase, or aldo-keto reductase (AKR) 1C2, eliminates the androgen s

28 The aldo-keto reductase (AKR) codeinone reductase (COR) cata

29 Aldo-keto reductase (AKR) family 1, member 7 (AKR1B7), a

30 Aldo-keto reductase (AKR) inhibitors blocked this effect

31 It is the only HSD of known structure in the aldo-keto reductase (AKR) superfamily and may provide a

32 Both enzymes are members of the aldo-keto reductase (AKR) superfamily and possess cataly

33 , E.C. 1.1.1.213, AKR1C9) is a member of the aldo-keto reductase (AKR) superfamily which inactivates

34 ase isoforms (AKR1C1-AKR1C4), members of the aldo-keto reductase (AKR) superfamily, activate trans-di

35 ydrogenase (3 alpha-HSD/DD), a member of the aldo-keto reductase (AKR) superfamily, oxidizes PAH tran

36 d potassium (Kv) channels are members of the aldo-keto reductase (AKR) superfamily.

37 hydroxysteroid dehydrogenases (HSDs) of the aldo-keto reductase (AKR) superfamily.

38 d with recombinant rat liver 3 alpha-HSD, an aldo-keto reductase (AKR) that plays critical roles in s

39 servation indicates that Kvbeta resembles an aldo-keto reductase (AKR), an enzyme that catalyzes a re

40 Aldose reductase (ALR2), a NADPH-dependent aldo-keto reductase (AKR), is widely distributed in mamm

41 Human aldo-keto reductase (AKR)1C isoforms have been shown to

42 Aldo-keto reductases (AKR) are monomeric oxidoreductases

43 e dehydrogenases, alcohol dehydrogenases and aldo-keto reductases (AKR).

44 We identify the aldo-keto reductase AKR1B10 as a metastasis enhancer tha

45 Aldo-keto reductase (AKR1C) isoforms can regulate ligand

46 g carcinoma, differential display shows that aldo-keto reductase (AKR1C) transcripts are dramatically

47 The human aldo-keto reductase AKR1C1 (20alpha(3alpha)-hydroxystero

48 Four human cytosolic aldo-keto reductases (AKR1C1-AKR1C4) are known to act as

49 show that four homogeneous human recombinant aldo-keto reductases (AKR1C1-AKR1C4) are regioselective

50 for monitoring the activity of the inducible aldo-keto reductases AKR1C2 and AKR1C3 in living human c

51 d isoform-selective (1500-fold) inhibitor of aldo-keto reductase AKR1C3: a target of interest in both

52 Dihydrodiol dehydrogenases are a family of aldo-keto reductases (AKR1Cs) involved in the metabolism

53 Aldo-keto reductases (AKRs) are a large superfamily of N

54 Aldo-keto reductases (AKRs) are ubiquitous in nature and

55 Aldo-keto reductases (AKRs) are widely distributed in na

56 Aldo-keto reductases (AKRs) comprise a superfamily of pr

57 on of intermediate PAH trans-dihydrodiols by aldo-keto reductases (AKRs) leads to the formation of el

58 PAH-diols can be converted to o-quinones by aldo-keto reductases (AKRs) or to diol-epoxides by cytoc

59 Human aldo-keto reductases (AKRs) regulate nuclear receptors b

60 dihydrodiol dehydrogenase (DD) isoforms are aldo-keto reductases (AKRs) that activate polycyclic aro

61 rodiol proximate carcinogens are oxidized by aldo-keto reductases (AKRs) to their corresponding react

62 zo[a]pyrene (B[a]P-7,8-trans-dihydrodiol) by aldo-keto reductases (AKRs) to yield benzo[a]pyrene-7,8-

63 0 proteins possess conserved motifs found in aldo/keto reductases (AKRs) of yeast and fungi.

64 novel carbonyl detoxifying enzymes, such as aldo-keto reductase and carbonyl reductase, were detecte

65 ion of Cbei_3974 and Cbei_3904, which encode aldo-keto reductase and previously annotated short chain

66 hydroxy-7,8-dihydroB[a]P by the mediation of aldo-keto reductases and its role in the genotoxicity an

67 ining substrate and inhibitor specificity of aldo-keto reductases and specifically identifies Arg311

68 rgeted for deletion: three genes that encode aldo-keto reductases and three genes that encode alcohol

69 tic hydrocarbon (PAH) o-quinones produced by aldo-keto reductases are ligands for the aryl hydrocarbo

70 d role for the metabolic enzymes enolase and aldo-keto reductase as positive and negative regulators

71 ydroxysteroid dehydrogenase (3alpha-HSD), an aldo-keto reductase, binds NADP(+) in an extended anti-c

72 Human aldo-keto reductases catalyze the metabolic activation o

73 We previously reported that Akr1b7, an aldo-keto reductase enriched in adipose stromal vascular

74 Identification of the aldo-keto reductase enzyme AKR1B10 as highly up-regulate

75 The aldo-keto reductase enzymes comprise a functionally dive

76 Recent studies have demonstrated that aldo-keto reductase family 1 B10 (AKR1B10), a novel prot

77 tivity from mammalian tissues and identified aldo-keto reductase family 1 member A1 (AKR1A1), the arc

78 The aldo-keto reductase family 1 member A1 gene (AKR1A1) was

79 Aldo-keto reductase family 1 member B10 (AKR1B10) is ove

80 Aldo-keto reductase family 1 member B10 (AKR1B10) is pri

81 Here, we identify aldo-keto reductase family 1 member B10 (AKR1B10), down-

82 ediated by inactivation of P4 in DS cells by aldo-keto reductase family 1 member C1 (AKR1C1).

83 Aldo-keto reductase family 1 member C3 (AKR1C3) is a mem

84 Aldo-keto reductase family 1 member C3 (AKR1C3) serves a

85 hesis of androgens (5alpha-reductase/SRD5A1, aldo-keto reductase family 1 member C3/AKR1C3), b) estab

86 ce of marker proteins for renin cells (e.g., aldo-keto reductase family 1, member 7 and connexin 40)

87 The increase in aldo-keto reductase family 1, member C3 (AKR1C3), the pr

88 sponding gene revealed that a protein of the aldo-keto reductase family carries out this reaction in

89 ess a functional homologue of yeast SCoR, an aldo-keto reductase family member (AKR1A1)(5) with an un

90 s high sequence identity with the genes from aldo-keto reductase family of proteins including the mou

91 Aldose reductase (AR), a member of the aldo-keto reductase family, has been implicated in the d

92 Aldose reductase, a member of the aldo-keto reductase family, has been implicated in the d

93 ductase modules, the latter belonging to the aldo-keto reductase family.

94 The aldo/keto reductase fold is structurally distinct from a

95 press the 3-ketosteroid reductase AKR1C9, an aldo-keto reductase gene family member.

96 xylose-pathway gene, a novel homolog of the aldo-keto reductase gene GRE3, while a second locus cont

97 sine residue found in the active site of all aldo-keto reductases have wild-type trafficking characte

98 rprisingly, AKR11B, the most closely related aldo-keto reductase in sequence.

99 molecular rationale to explore the status of aldo-keto reductases in dysregulations of adipose tissue

100 ssypolone, revealing a noncanonical role for aldo-keto reductases in extracellular terpenoid metaboli

101 a-galactosidase, nuclease, transaminase, and aldo-keto reductase) in native proteomes of marine sedim

102 revealed surprising structural homology with aldo-keto reductases, including a triosephosphate isomer

103 The aldo-keto reductases make up a superfamily of enzymes wh

104 The latter involves aldo-keto reductase mediated oxidation of PAH dihydrodio

105 determined for a xylose reductase, a dimeric aldo-keto reductase or a family 2 aldo-keto reductase.

106 t throughout the remainder of the oligomeric aldo-keto reductases, predicting alternate modes of olig

107 We identified a gene encoding a tomato aldo/keto reductase, Sl-AKR9, that is associated with ph

108 ein has highest sequence similarity to other aldo-keto reductases, such as chalcone reductase, an enz

109 a mammalian HSD using rat 3alpha-HSD of the aldo-keto reductase superfamily (AKR1C9) with the substr

110 o all other characterized human genes of the aldo-keto reductase superfamily (aldose reductase, bile

111 n 3alpha-HSDs and 20alpha-HSDs belong to the aldo-keto reductase superfamily and share 67% amino acid

112 The ALDRXV4 belongs to the aldo-keto reductase superfamily of enzymes that catalyze

113 or NADH and belongs to the largely monomeric aldo-keto reductase superfamily of proteins.

114 esidues as are found in other members of the aldo-keto reductase superfamily that are naturally able

115 Thus, HSDs in the aldo-keto reductase superfamily thermodynamically favor

116 It belongs to the NADPH-dependent aldo-keto reductase superfamily whose members are in par

117 ensitive K(+) (K(v)) channels belongs to the aldo-keto reductase superfamily, and the crystal structu

118 id reductase A (2,5-DKGR A), a member of the aldo-keto reductase superfamily, has been determined by

119 Aldose reductase (AR), a member of the aldo-keto reductase superfamily, has been implicated in

120 Aldose reductase (AR), a member of the aldo-keto reductase superfamily, has been shown to metab

121 hydrogenase (3alpha-HSD/DD), a member of the aldo-keto reductase superfamily, inactivates circulating

122 e analyses showed M6PR to be a member of the aldo-keto reductase superfamily, which includes both ani

123 Aldose reductase (AR) is a member of the aldo-keto reductase superfamily.

124 en aldose reductase and other members of the aldo-keto reductase superfamily.

125 been solved for a prokaryotic example of the aldo-keto reductase superfamily.

126 approximately 36 kDa protein related to the aldo-keto reductase superfamily.

127 ide-binding beta-subunits that belong to the aldo-keto reductase superfamily.

128 lected yghZ, a gene encoding a member of the aldo-keto reductase superfamily.

129 ow been solved for a human HSD member of the aldo-keto reductase superfamily.

130 dopts the three-dimensional structure of the aldo/keto reductase superfamily.

131 , previously shown to be a broad specificity aldo-keto reductase that converts MG to acetol.

132 Aldose reductase (AR) is an aldo-keto reductase that has been widely investigated as

133 these proteins function synergistically with aldo-keto reductases to catalyze the hydroxylation of he

134 reated a fusion consisting of a thermostable aldo-keto reductase, two alpha-helical leucine zipper do

135 y (steroid 5alpha-reductase type 1 [SRD5A1], aldo-keto reductase type 1C2 [AKR1C2], aldo-keto reducta

136 5A1], aldo-keto reductase type 1C2 [AKR1C2], aldo-keto reductase type 1C4 [AKR1C4], cytochrome P450 1

137 Here, we identified a V. vinifera aldo-keto reductase, Vv2KGR, with 2-keto-l-gulonic acid

138 i.e., Kvbeta), which are NAD(P)(H)-dependent aldo-keto reductases, we tested the hypothesis that oxyg

139 these reactions (fatty acid synthase, Fasp; aldo-keto reductase, Ypr1p; alpha-acetoxy ketone reducta