ライフサイエンスコーパス: aldol

1 ction, Kumada coupling, and Crimmins acetate aldol.

2 H932 imidazole to the alpha,beta-unsaturated aldol.

3 We also measure the kinetic parameters of aldol addition and demonstrate engineering of the hydrox

4 MP) superbase was found to facilitate direct aldol addition by providing the strong Bronsted basicity

5 ble to bring about the envisioned biomimetic aldol addition cascade and gained insights into the feas

6 he latter transformation is straightforward: aldol addition followed by Wittig olefination and dehydr

7 ased nucleophile (e.g., one enzyme-catalyzed aldol addition involving trichloromethyl ketones, and no

8 The in-ice nonenzymatic aldol addition leads to the continuous accumulation of f

9 The key step comprises the aldol addition of 3,3-disubstituted 2-oxoacids to aldehy

10 ethylglutaryl synthase (HMGS), catalyzes the aldol addition of an acyl donor to a beta-keto-polyketid

11 e to the corresponding products obtained via aldol addition of boron enolates to enals using the same

12 catalyzes the reversible and stereospecific aldol addition of dihydroxyacetone phosphate (DHAP) and

13 1-phosphate aldolase F131A-variant-catalyzed aldol addition of dihydroxyacetone phosphate to aldehyde

14 n of an aldehyde or ketone substrate affords aldol addition products that are stereochemically homolo

15 landmark publications of the first directed aldol addition reaction in 1973, the site, diastereo-, a

16 ated the development of Lewis base catalyzed aldol addition reactions.

17 The key step is a bioinspired aldol addition to set the stereogenic center in an inter

18 An unusual intramolecular aldol addition was developed for the assembly of its cyc

19 n-Bu2BOTf) and trialkylamines and subsequent aldol addition was probed structurally and mechanistical

20 Rate studies show that the aldol addition with isobutyraldehyde occurs as proffered

21 nts of FBP aldolase stereospecificity during aldol addition, a key ternary complex formed by DHAP and

22 ition, followed by fragmentation, vinylogous aldol addition, oxidative lactonization, and a final ben

23 ioselective formaldehyde C-C coupling beyond aldol addition.

24 etene-first", with carbocyclization prior to aldol addition.

25 A catalytic asymmetric aldol addition/cyclization reaction of unactivated keton

26 ossible utility of lithium enolates in Evans aldol additions are discussed.

27 Controlling regio- and stereoselectivity of aldol additions is generally challenging.

28 Aldol additions to isobutyraldehyde and cyclohexanone wi

29 Stereoselective quaternizations, aldol additions, and azaaldol additions are described.

30 and tested as organocatalysts in asymmetric aldol additions.

31 stidine followed by biotransformation of the aldol adduct by an alcohol dehydrogenase without the nee

32 The aldol adducts are obtained in excellent yield with high

33 oselectivity features the production of anti-aldol adducts from alpha,beta-unsaturated ketones and al

34 The absolute configuration of the imino-aldol adducts has been determined.

35 ination of the NMR data for the above set of aldol adducts revealed consistent trends that were explo

36 (methoxymethoxy)-4,6,8-trimethylnonan-5 -one aldol adducts were confirmed by NMR analysis of 12 aceto

37 te and many (hetero)aromatic aldehydes yield aldol adducts without subsequent dehydration.

38 equently ring-opened to produce ketone-based aldol adducts, providing an alternative to the Mukaiyama

39 riethylsilyloxy)-4,6,8-trimethylnonan -5-one aldol adducts.

40 kinetically controlled products via a domino aldol-aldol reaction sequence with excellent diastereose

41 c control operating in this multistep domino-aldol-aldol-hemiacetal protocol was used for probing the

42 The domino-aldol-aldol-hemiacetal-reaction cascade of indium and ot

43 d for the synthesis of a chiral cyclopropane aldol and a gamma-lactone in a >95:5 diastereomeric rati

44 h ee has been developed via asymmetric imino-aldol and aldol reactions, respectively, starting from p

45 ermit to modulate asymmetric quimioselective aldol and conjugate addition reactions.

46 This approach could produce a series of aldol and Mannich products from enol carbamate with exce

47 In this review, direct catalytic reductive aldol and Mannich reactions are exhaustively catalogued

48 classical (Robinson annulation and Mukaiyama aldol) and two are newly devised.

49 ied to the enantioselective alpha-amination, aldol, and alpha-aminoxylation/alpha-hydroxyamination re

50 alternative to base-mediated enolization in aldol- and Mannich-type reactions.

51 was achieved using a sequential Diels-Alder/aldol approach in a highly diastereoselective manner.

52 Condensation reactions such as Guerbet and aldol are important since they allow for C-C bond format

53 protocol entails a highly diastereoselective aldol/Brook rearrangement/cyclization cascade.

54 dergo a Michael/aldol/hemiketalization/retro-aldol cascade for the formation of 3-acetoxyindanones po

55 The enantioselective vinylogous Michael/aldol cascade is an underdeveloped approach to cyclohexe

56 tly undergo base-promoted diastereoselective aldol cascade reactions resulting in the natural or unna

57 stolactam, which was prepared using a Suzuki/aldol cascade to convert a differentially protected isoi

58 by using either tertiary amines or a dizinc aldol catalyst constitute two parallel routes to the de

59 The combination of a distinct retro-aldol catalyst with a 1,2-HS catalyst enables lactic aci

60 Due to a lack of efficient retro-aldol catalysts, most previous investigations of catalyt

61 be compatible with the aforementioned retro-aldol catalysts.

62 substituted conjugated diene, non-Evans syn aldol, CBS reduction, Hantzsch's thiazole synthesis, Hor

63 The enzyme-catalyzed retro-aldol cleavage of 2-VIC unmasks a Michael substrate, 2-v

64 but had similar activity in THF-independent aldol cleavage of beta-hydroxyamino acid.

65 ass I aldolase that catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (Neu5Ac) from

66 ound that the overall rate-limiting step for aldol cleavage shifted from C-C bond scission (or an ear

67 de intermediate by stereodirected vinylogous aldol condensation (SVAC), (ii) installation of the amin

68 Subsequent intramolecular aldol condensation afforded the indenones.

69 ce alkylresorcinols and alkylpyrones through aldol condensation and lactonization of the same polyket

70 ione, followed by spontaneous intramolecular aldol condensation and leads to the formation of an azat

71 anding challenge because of competitive self-aldol condensation and multiple arylations.

72 d to investigate the cooperatively catalyzed aldol condensation between acetone and 4-nitrobenzaldehy

73 on of the acetone intermediate and the cross-aldol condensation between the reaction intermediates ac

74 yclization specificity from lactonization to aldol condensation for a type III PKS.

75 alpha,beta-unsaturated ketone and subsequent aldol condensation has been developed using a Cp*Co(CO)I

76 enabling a mediocre prolinamide to catalyze aldol condensation in water with excellent yields and ee

77 Although aldol condensation is one of the most important organic

78 The cascade reaction proceeds via a cross-aldol condensation of 2-(1H-imidazol-1-yl/benzimidazolyl

79 The intramolecular aldol condensation of 4-substituted heptane-2,6-diones l

80 Y-DeAlBEA and Zn-DeAlBEA does not occur via aldol condensation of acetaldehyde but, rather, by conce

81 ino reactions, namely a domino sulfa-Michael/aldol condensation of alpha,beta-unsaturated aldehydes w

82 Sn-, and Zr-Beta zeolites catalyze the cross-aldol condensation of aromatic aldehydes with acetone un

83 the rate-limiting step in the base-catalyzed aldol condensation of benzaldehydes with acetophenones,

84 on of arylvinylquinazolines was performed by aldol condensation of the appropriate methylquinazoline

85 C12-C13 of providencin using intermolecular aldol condensation of the enolate from the selenyl lacto

86 osphoramidite binaphthol ligand, followed by aldol condensation of the resulting aluminum enolate wit

87 carbon bonds as cleaved in glycolysis in an aldol condensation of the unstable catabolites glycerald

88 carboxaldehyde shows that MppR catalyzes the aldol condensation of these compounds and subsequent deh

89 mediate can be folded to a suitable form for aldol condensation only in such a relatively narrow cavi

90 ng with a diketopiperazine precursor, a mild aldol condensation precedes pyrrole annulation and bicyc

91 ion and characterization of the intermediate Aldol condensation product.

92 The derived intermediate aldol condensation products, which bear either a protect

93 dol reaction, a Mannich reaction, and a self-aldol condensation reaction.

94 In particular, the observation of direct aldol condensation reactions enabled by hydrophobic zeol

95 action to set up the whole carbon framework, aldol condensation to construct the highly substituted c

96 tion/ring-opening followed by intramolecular aldol condensation under microwave irradiation is descri

97 reaction of 2-pyridylacetate followed by the Aldol condensation under mild reaction conditions has be

98 -s-triazine tautomers in situ, which undergo Aldol condensation with 4,4'-biphenyldicarbaldehyde in o

99 cyclotrimerization of nitrile and subsequent aldol condensation with aldehydes-in one pot.

100 ion of the cyclopropyl alcohols, followed by aldol condensation with the pentamethyl phenyl-substitut

101 s a domino reaction sequence that employs an aldol condensation, alkene isomerization, and intramolec

102 include reduction of ketones to alcohols and aldol condensation, both reactions that are common in ex

103 oluene using Dean-Stark apparatus, where the aldol condensation, cyclopropyl ring opening followed by

104 (PT) domain of PhnA catalyzes only the C4-C9 aldol condensation, which is unprecedented among known P

105 ization and a subsequent base-mediated retro-aldol condensation.

106 dition followed by an intramolecular enamine aldol condensation.

107 iger oxidation and subsequent intramolecular aldol condensation.

108 d 4,4'-biphenyldicarbaldehyde (BPDA) through Aldol condensation.

109 hienyl ether derivatives via a well-designed aldol condensation/regioselective intramolecular cycliza

110 duction of C(4) aldehydes via base-catalyzed aldol-condensation.

111 High-temperature, TiCl4-catalyzed, triple aldol condensations of aceanthrenone 5 and acenaphthacen

112 We probed tandem aldol condensations of sixteen o-hydroxyacetophenones, c

113 The use of common aldol conditions resulted in predominant syn-addition vi

114 A subsequent Mukaiyama aldol coupling allows for the incorporation of a wide ar

115 Asymmetric anti-aldol coupling of a norephedrine-derived ester with an a

116 ickel and copper hydroxides catalyze the key aldol coupling reaction of acetaldehyde to exclusively y

117 achieved by different synthetic versions of aldol-coupling reactions, catalyzed either by organocata

118 hesis include Evans alkylation, Crimmins syn-aldol, Crimmins acetate aldol, Wittig olefination, and S

119 rom native molecules that had intramolecular aldol cross-links at each end.

120 uently reduced to initiate an intramolecular aldol cyclization to [3.2.1], [3.3.1], and [4.3.1] bicyc

121 of malonyl-CoA and catalyzes decarboxylative aldol cyclization to yield the pentaketide 2'-oxoalkylre

122 x, tandem conjugate reduction/intramolecular aldol cyclization, and oxidative dearomatization.

123 NR-PKSs) are responsible for controlling the aldol cyclizations of poly-beta-ketone intermediates ass

124 nzymes in bacteria, regiospecific first-ring aldol cyclizations result in characteristically differen

125 e Cu(OTf)2-catalyzed Michael reaction/tandem aldol cyclizations, and one-pot reduction/transposition

126 The tandem aldol-decarbonylation reaction opens the door to explora

127 atom-economical olefination of carbonyls via aldol-decarbonylative coupling of aldehydes using robust

128 ive and silver nanoparticle-mediated bridged aldol/dehydration to construct the [3.3.1] ring system.

129 d this conclusion and found that telopeptide aldol dimerization is the primary mechanism for stable c

130 ed on 3 catalyzed the prebiotically relevant aldol dimerization of glycolaldehyde to give threose and

131 The C-telopeptide aldol dimers formed labile addition products with glucos

132 ohydride reduction of N-telopeptide allysine aldol dimers in aldimine intermolecular linkage to nongl

133 scalable protocol involving a one-pot cross-Aldol direct arylation reaction protocol for the rapid c

134 ase with high specificity for acetone as the aldol donor can be reengineered via single active site m

135 ulate the binding and activation of specific aldol donors, as well as their subsequent reaction with

136 ceed via a Dieckmann cyclization and a retro-aldol elimination, releasing ammonia and D-erythronate-4

137 gly correlated to the enolate geometry: anti aldols from (E)-enolates and syn aldols from (Z)-enolate

138 metry: anti aldols from (E)-enolates and syn aldols from (Z)-enolates.

139 ldehydes and 1,3-carbonyls undergo a Michael/aldol/hemiketalization/retro-aldol cascade for the forma

140 The domino aldol/hetero-Diels-Alder synthesis of some new tricyclic

141 plication in various methodologies including aldol-lactonisations, Michael-lactonisations/lactamisati

142 ty of the nucleophile-catalyzed (Lewis base) aldol lactonization (NCAL) process for the diastereo- an

143 yclic carbene (NHC)-catalyzed intramolecular aldol lactonization of readily available ketoacids leadi

144 elective intramolecular nucleophile-assisted aldol-lactonization was employed, leading to a beta-lact

145 y the same reaction conditions via a Michael/aldol/lactonization/decarboxylation cascade.

146 An aldol-like cyclocondensation has been used to prepare he

147 y the hydroxylated intermediate undergoes an aldol-like phenoxide-ketone cyclization to yield the phe

148 alytically degrades via an unexpected 'retro-aldol-like' cleavage mechanism to a C18 aldehyde which i

149 ergistic catalyst for the List-Lerner-Barbas aldol (LLB-A) reaction of less reactive 2-azidobenzaldeh

150 nge of asymmetric transformations, including aldol, Mannich, and Henry reactions, as well as alkynyla

151 procedure, some NHC-catalyzed sulfa-Michael/aldol organocascades were also investigated.

152 radical cyclization, and a tandem oxidation-aldol-oxidation are the key features of our methodology.

153 fficient, and nontoxic transition-metal free aldol polycondensation.

154 hol moiety instead derived its preferred (R)-aldol product from an interplay between sterics and elec

155 zation was responsible for the exclusive (S)-aldol product in the antibody, the organocatalyst featur

156 vans' syn-aldol reactions is described, with aldol products being cleaved from the polymer by either

157 , and consequently, the R/S configuration of aldol products can be tuned by the use of either commerc

158 Single-crystal X-ray studies reveal that the aldol products can self-assemble to form supramolecular

159 The utility of the aldol products has been highlighted with the synthesis o

160 The configuration of the aldol products is controlled by the proline chirality, a

161 r hydration, various beta-alkylation or beta-aldol products of the ketones are obtained with broad fu

162 The corresponding aldol products were obtained in high yields and good to

163 th unexpectedly resulted in the formation of aldol products with 6/7/5/5-fused molecular skeleton via

164 tion rate and the enantiomeric excess of the aldol products.

165 able and economical entry into syn- and anti-aldol products.

166 d excellent de by a zinc-ProPhenol-catalyzed aldol reaction and a palladium-catalyzed asymmetric ally

167 ehydrogenation to the ketone, followed by an aldol reaction and hydrogenation of the resulting enone.

168 New insight into the synthetically important aldol reaction and state-of-the-art methodology is prese

169 and an aqueous acid-catalyzed intramolecular aldol reaction are the key synthetic steps.

170 eveloped that relies on a diastereoselective aldol reaction between a suitably protected hydantoin an

171 The aldol reaction between benzaldehyde and acetone has been

172 ve 1 was initially found to catalyze a model aldol reaction between cyclohexanone and 4-nitrobenzalde

173 A zinc-ProPhenol-catalyzed direct asymmetric aldol reaction between glycine Schiff bases and aldehyde

174 orresponding seco acid 32 originated from an aldol reaction between methyl ketone 6 and methyl (E)-3-

175 lphenoxide) (ATNP), in the doubly vinylogous aldol reaction between methyl-5-methyl-2-furoate and ald

176 Stereoselective direct aldol reaction between optically pure d- or l-glyceralde

177 This process consists of an initial aldol reaction catalyzed by readily available l-histidin

178 d product forms a tricyclic derivative under aldol reaction conditions, which can be a potential prec

179 The unexpected retroaldol-aldol reaction during O-alkylation of a beta-hydroxy lac

180 le starting materials and coupled through an aldol reaction followed by dehydration to afford stereos

181 , the site, diastereo-, and enantioselective aldol reaction has been elevated to the rarefied status

182 The directed aldol reaction has served as a fertile proving ground fo

183 in what can be considered an N-selective HNO-aldol reaction in up to quantitative yields.

184 was shown to promote enantioselective direct aldol reaction of 7-iodoisatin and 2,2-dimethyl-1,3-diox

185 tic system for the asymmetric direct crossed-aldol reaction of acetaldehyde in aqueous media using br

186 lex as catalyst for the vinylogous Mukaiyama aldol reaction of bis(silyl) diendiolate 1 and an aldehy

187 had significantly increased activity for the aldol reaction of erythrose with pyruvate compared with

188 equence is a transition metal/base-catalyzed aldol reaction of methyl isocyanoacetate and difluoroace

189 An uncatalyzed aldol reaction of N-substituted thiazolidinediones with

190 imental observation that the activity of the aldol reaction on mesoporous silica depends on the lengt

191 oes a catalyst-free stereoselective transfer aldol reaction on water.

192 hetic utility of this chemistry, the racemic aldol reaction product was converted in five steps to a

193 Alternatively, an aldol reaction provided access to the same analogue in a

194 ion of ketones and a tandem radical addition-aldol reaction sequence to access vicinal quaternary ste

195 preparation are: (i) a stereoselective boron-aldol reaction to afford the acyclic carbon skeleton of

196 c system worked well in water for the direct aldol reaction to afford the products in excellent yield

197 o features an early-stage diastereoselective aldol reaction to assemble the substituted cyclopentanon

198 Synthetic highlights include a Crimmins aldol reaction to construct the C-1' and C-14 centers, a

199 C5-C11 polyol fragment, a diastereoselective aldol reaction to control the stereogenic center at C13,

200 alpha-ketol rearrangement, and a late stage aldol reaction to furnish the complex cage-like framewor

201 d as chiral auxiliary for asymmetric acetate aldol reaction to generate initial chirality in the targ

202 he C-1' and C-14 centers, a Crimmins acetate aldol reaction to generate the hydroxy group at the C-13

203 nthesis include a stereoselective vinylogous aldol reaction to introduce the unusual dichloromethyl s

204 hexene inhibitor that features an asymmetric aldol reaction using a titanium enolate, diastereoselect

205 An organocatalytic enantioselective aldol reaction using paraformaldehyde as C1-unit has bee

206 Moreover, a related aldol reaction was also developed.

207 An intramolecular L-proline-mediated aldol reaction was employed to generate the cis-configur

208 combination of an asymmetric organocatalytic aldol reaction with a subsequent biotransformation towar

209 to an alkynone followed by an intramolecular aldol reaction with a tethered aldehyde to afford a cycl

210 th subsequent silyl trapping and a Mukaiyama aldol reaction with aqueous formaldehyde.

211 egy is based on two key reactions: first, an aldol reaction with formaldehyde in order to introduce s

212 The resulting enzyme catalyses a reversible aldol reaction with high stereoselectivity and tolerates

213 The first involved a direct aldol reaction with hydroxyacetone, dihydroxyacetone, or

214 ategy-level reaction (the Mukaiyama directed aldol reaction).

215 d the light-triggered catalysis of a crossed aldol reaction, a Mannich reaction, and a self-aldol con

216 minal alkyne to acceptor alkyne, a Mukaiyama aldol reaction, a Yamaguchi esterification, and a homema

217 an cyclization, a chiral Lewis acid mediated aldol reaction, and a facile amide union.

218 thioester cleavage, sulfa-Michael addition, aldol reaction, and elimination reaction sequences to pr

219 oups that are known to undergo 1,2-addition, aldol reaction, and O-, N-, enolate-alpha-, and C(sp(2))

220 but-2-ene-1,4-dione surrogate, Nagao acetate aldol reaction, and Shiina lactonization.

221 chiral auxiliary mediated asymmetric acetate aldol reaction, dianion addition, and base mediated cycl

222 our propionate diastereoisomers combining an aldol reaction, followed by a stereoselective radical-ba

223 is synthesis highlights a scalable Mukaiyama aldol reaction, Nicolaou-type epoxide opening reaction,

224 s, undergoing an N-selective nitrosocarbonyl aldol reaction.

225 sertion but is diverted by an intermolecular aldol reaction.

226 talysis, as demonstrated here for the chiral aldol reaction.

227 action, but is diverted by an intramolecular aldol reaction.

228 xylation, and a 1,3-anti-selective Mukaiyama aldol reaction.

229 active in ionic liquid/aqueous media for the aldol reaction.

230 hetic steps using a trifluoroacetate-release aldol reaction.

231 eactivation of secondary amines by undesired aldol reaction.

232 s, providing an alternative to the Mukaiyama aldol reaction.

233 tereogenic center at C-2 via a thermodynamic aldol reaction.

234 by nature for biological chemistry including aldol reactions being essential for glycolysis, gluconeo

235 The sources of asymmetric induction in aldol reactions catalyzed by cinchona alkaloid-derived a

236 The transition states of aldol reactions catalyzed by vicinal diamines are charac

237 s include a series of highly stereoselective aldol reactions followed by directed reductions to build

238 Retro-aldol reactions have been implicated as the limiting ste

239 merisation, transfer-hydrogenation and retro-aldol reactions have emerged as relevant transformations

240 velopments in the area of aqueous asymmetric aldol reactions highlighting two fundamental directions-

241 nd then directly engaged in enantioselective aldol reactions in a one-pot reaction.

242 ng an organocatalytic cascade of Michael and aldol reactions in the presence of a chiral thiourea cat

243 , artificial catalysts designed and used for aldol reactions in water can be promising for the synthe

244 ction of carbonyl or imine electrophiles and aldol reactions initiated via enone conjugate addition a

245 iastereoselective solid-supported Evans' syn-aldol reactions is described, with aldol products being

246 The enantioselectivity in the aldol reactions is reversed if the reactions are carried

247 The diastereoselectivities of aldol reactions of 2-methylpropanal with various enolate

248 Enantioselective aldol reactions of acetophenone with beta,gamma-unsatura

249 laldehyde, but cannot readily catalyze retro-aldol reactions of hexoses and pentoses at these moderat

250 or Horner-Emmons olefinations, and directed aldol reactions of lithium enolates), the one-pot proces

251 gh trans- and syn-diastereoselectivities for aldol reactions of SF5-acetates with aldehydes in the pr

252 Enabled by the highly stereocontrolled aldol reactions of three chiral ketone building blocks,

253 ate-temperature (around 100 degrees C) retro-aldol reactions of various hexoses in aqueous and alcoho

254 syn-Selective aldol reactions realized by using either tertiary amines

255 This catalyst promotes aldol reactions that form rings containing 14 to 22 atom

256 This strategy relies on two aldol reactions to install the chiral centers at C3/C4 a

257 lyst has been developed for asymmetric cross-aldol reactions under neat conditions in ketone-ketone,

258 Four vicinal diamine-catalyzed aldol reactions were examined.

259 Three boron aldol reactions were used to assemble the linear carbon

260 Boron-mediated aldol reactions were used to configure the three key fra

261 CBS reduction, and proline-catalyzed crossed-aldol reactions were utilized as key steps for the gener

262 e (1) and characterization of representative aldol reactions with aldehydes and ketones.

263 tetrasubstituted enolborinates which undergo aldol reactions with aldehydes to form products with all

264 lyze both Mukaiyama-Mannich and oxocarbenium aldol reactions with high efficiency and enantioselectiv

265 This opens a new route to iterative aldol reactions, and it has been used for the synthesis

266 ther not so commonly used processes (such as aldol reactions, cyclizations, and isomerizations) will

267 loyed as an asymmetric catalyst in Mukaiyama aldol reactions, generating enantioselectivities of up t

268 een developed via asymmetric imino-aldol and aldol reactions, respectively, starting from protected a

269 reactivity and stereochemical selectivity in aldol reactions, the ability to catalyze Henry reactions

270 models for diastereoselective methyl ketone aldol reactions, the discovery of a spontaneous Horner-W

271 line esters are efficient organocatalysts of aldol reactions, these results permit to modulate asymme

272 re catalytically competent toward asymmetric aldol reactions, were selected as the catalytic unit.

273 ric allylation, ring closing metathesis, and aldol reactions.

274 additions, aza-Michael additions, and direct Aldol reactions.

275 ed as a substrate for divergent transannular aldol reactions.

276 olecular oxa-Michael addition-intramolecular aldol reactions.

277 ach involving asymmetric Mannich-type (imino-aldol) reactions of methyl phenylacetate with N-tert-but

278 DMF, O-alkylation is faster than retroaldol-aldol rearrangement giving exclusively products with ret

279 Aldol relative topicity (simple diastereoselectivity) wa

280 ble pathway is a stepwise conjugate addition-Aldol sequence via the dual hydrogen-bond binding mode.

281 Furthermore, a Michael/aldol sequence was developed for the construction of the

282 en different reaction pathways (Henry versus aldol) that compete for a common substrate.

283 F-5 topologies, the reaction is selective to Aldol-Tishchenko products, the 1 and 3 n-alkylesters of

284 amework, it becomes an electrophile yielding Aldol-Tishchenko selectivity.

285 s a masked OH at C6, (iii) an oxymercurative aldol to synthesize the tricyclo[5.3.2.0(1,6)]decene moi

286 eferences of a hydrogen-bonded nine-membered aldol transition state containing eight heavy atoms.

287 Mukaiyama-aldol type reactions of acetals derived from enolizable

288 Aldol-type addition of alpha-triethylsilyl-alpha-diazoac

289 rocedure to the low-temperature LDA-promoted aldol-type addition of diazoacetone.

290 ell-defined precursors for a wide variety of aldol-type compounds.

291 lene compounds and concurrent intramolecular aldol-type condensation of S-alkylated compounds affords

292 rization, imine formation, ammonia addition, aldol-type condensation, cyclization, and aromatization,

293 The mechanistic insight toward the aldol-type cyanomethylation of N-tritylisatin with benzy

294 ansaldolase that catalyzes a threo-selective aldol-type reaction to generate the thioheptose core wit

295 onvergent strategy comprise a boron-mediated aldol union to set the C(15)-C(17) syn-syn triad, reagen

296 c excesses (ee = 43-56%) but did not produce aldols with either hydroxyacetone or dihydroxyacetone as

297 ting materials, leading to the corresponding aldols with lower yields, but efficiently.

298 lation, Crimmins syn-aldol, Crimmins acetate aldol, Wittig olefination, and Shiina macrolactonization

299 ism of the former is a tandem gamma-umpolung/aldol/Wittig/dehydration process, as established by prep

300 synthetic strategy include modified Crimmins aldols, Yamaguchi esterification, and Grubbs ring-closin