ライフサイエンスコーパス: aldol reaction

1 ategy-level reaction (the Mukaiyama directed aldol reaction).

2 hetic steps using a trifluoroacetate-release aldol reaction.

3 s, providing an alternative to the Mukaiyama aldol reaction.

4 via a previously uncharacterized retro oxime-aldol reaction.

5 lectivity was observed in the intramolecular aldol reaction.

6 the stereochemical outcome of the asymmetric aldol reaction.

7 pplications as a catalyst for the asymmetric aldol reaction.

8 gment utilized a chiral auxiliary based anti-aldol reaction.

9 gate to the traditional vinylogous Mukaiyama aldol reaction.

10 rding the role of dimeric 2 in the Mukaiyama aldol reaction.

11 rted by mass spectrometry, is due to a retro-aldol reaction.

12 rols the absolute stereochemistry of the key aldol reaction.

13 diastereocontrol in a tandem chain-extension-aldol reaction.

14 tereogenic center at C-2 via a thermodynamic aldol reaction.

15 its use in the high-yielding aldehyde cross-aldol reaction.

16 for the divergent selectivity trends in the aldol reaction.

17 led to the development of a new tandem aldol-aldol reaction.

18 ation of the C-C bonds is a stepwise Michael-aldol reaction.

19 2) has been completed using a boron-mediated aldol reaction.

20 onal docking of the transition states of the aldol reaction.

21 chanism of the nornicotine-catalyzed aqueous aldol reaction.

22 electivity and represents a surrogate to the aldol reaction.

23 ences the selectivity of the lithium enolate aldol reaction.

24 s, undergoing an N-selective nitrosocarbonyl aldol reaction.

25 sertion but is diverted by an intermolecular aldol reaction.

26 talysis, as demonstrated here for the chiral aldol reaction.

27 action, but is diverted by an intramolecular aldol reaction.

28 xylation, and a 1,3-anti-selective Mukaiyama aldol reaction.

29 active in ionic liquid/aqueous media for the aldol reaction.

30 eactivation of secondary amines by undesired aldol reaction.

31 electivity in Lewis-acid-catalyzed Mukaiyama aldol reactions.

32 olecular oxa-Michael addition-intramolecular aldol reactions.

33 ences of the cyclic protecting groups on the aldol reactions.

34 ations have been tested as catalysts for the aldol reactions.

35 ly observed high syn diastereoselectivity of aldol reactions.

36 nprecedented mechanistic subtlety of aqueous aldol reactions.

37 (4R)-4-benzyl-2-oxazolidinone-mediated boron aldol reactions.

38 he use of two new asymmetric boron glycolate aldol reactions.

39 es as compared to secondary enamine-mediated aldol reactions.

40 ric allylation, ring closing metathesis, and aldol reactions.

41 additions, aza-Michael additions, and direct Aldol reactions.

42 ed as a substrate for divergent transannular aldol reactions.

43 d the light-triggered catalysis of a crossed aldol reaction, a Mannich reaction, and a self-aldol con

44 minal alkyne to acceptor alkyne, a Mukaiyama aldol reaction, a Yamaguchi esterification, and a homema

45 through catalytic enantioselective reductive aldol reactions, a catalytic Negishi coupling, and a cat

46 or antibodies 84G3- and 93F3-catalyzed retro-aldol reactions, allowing the preparation of highly enan

47 d by a catalytic enantioselective vinylogous aldol reaction and a boron-mediated anti-aldol reaction

48 d excellent de by a zinc-ProPhenol-catalyzed aldol reaction and a palladium-catalyzed asymmetric ally

49 In addition, an asymmetric anti aldol reaction and a two-directional oxocarbenium ion/vi

50 age is used to assign stereochemistry of the aldol reaction and as the final step in a short synthesi

51 ted aminoacids followed by an intramolecular aldol reaction and cyclization has been developed.

52 ehydrogenation to the ketone, followed by an aldol reaction and hydrogenation of the resulting enone.

53 th aldol donor and acceptor molecules in the aldol reaction and is, therefore, of particular interest

54 mploying an intramolecular iodo halo-Michael aldol reaction and its merger with an ABCD ring fragment

55 New insight into the synthetically important aldol reaction and state-of-the-art methodology is prese

56 d mechanism of nornicotine-catalyzed aqueous aldol reactions and also provide the basis for future st

57 g Wittig, conjugate addition, and asymmetric aldol reactions and found to be reversible competitive i

58 an cyclization, a chiral Lewis acid mediated aldol reaction, and a facile amide union.

59 displayed a higher k(cat) value in the retro-aldol reaction, and a linear relationship was observed i

60 e cyclization, a selective 1,2-syn Mukaiyama aldol reaction, and a Noyori reduction.

61 thioester cleavage, sulfa-Michael addition, aldol reaction, and elimination reaction sequences to pr

62 oups that are known to undergo 1,2-addition, aldol reaction, and O-, N-, enolate-alpha-, and C(sp(2))

63 but-2-ene-1,4-dione surrogate, Nagao acetate aldol reaction, and Shiina lactonization.

64 This opens a new route to iterative aldol reactions, and it has been used for the synthesis

65 ts and the origins of the selectivity of the aldol reaction are discussed on the basis of the results

66 and an aqueous acid-catalyzed intramolecular aldol reaction are the key synthetic steps.

67 rimmins' titanium-mediated oxazolidinethione aldol reactions are disclosed.

68 arbohydrates by using organocatalytic direct aldol reaction as a key step.

69 and minor nicotine metabolite, can catalyze aldol reactions at physiological pH.

70 mediated TMAL process versus other Mukaiyama aldol reactions based on our experimental evidence to da

71 by nature for biological chemistry including aldol reactions being essential for glycolysis, gluconeo

72 ed organocatalytic asymmetric domino Michael-aldol reaction between 3-substituted oxindoles and methy

73 eveloped that relies on a diastereoselective aldol reaction between a suitably protected hydantoin an

74 y of various organocatalysts to catalyze the aldol reaction between acetone and 2,2,2-trifluoromethyl

75 m, and its catalytic potential in the direct aldol reaction between acetone and 4-nitrobenzaldehyde w

76 The Mukaiyama aldol reaction between aldehyde 60c and the TMS enol eth

77 The aldol reaction between benzaldehyde and acetone has been

78 ve 1 was initially found to catalyze a model aldol reaction between cyclohexanone and 4-nitrobenzalde

79 ide (16S,17S)-adduct 51 and a boron-mediated aldol reaction between enone 10 and aldehyde 9, exploiti

80 A zinc-ProPhenol-catalyzed direct asymmetric aldol reaction between glycine Schiff bases and aldehyde

81 orresponding seco acid 32 originated from an aldol reaction between methyl ketone 6 and methyl (E)-3-

82 lphenoxide) (ATNP), in the doubly vinylogous aldol reaction between methyl-5-methyl-2-furoate and ald

83 Stereoselective direct aldol reaction between optically pure d- or l-glyceralde

84 F fragments followed by a diastereoselective aldol reaction between the CDEF ketone and an AB aldehyd

85 in of diastereo- and enantioselectivities of aldol reactions between aldehydes catalyzed by histidine

86 d catalyst affords asymmetric intermolecular aldol reactions between unmodified ketones and various a

87 tive and proline that can eliminate the self-aldol reactions by suppressing an irreversible aldol con

88 The process features a one-pot tandem aldol reaction catalyzed by a deoxyribose-5-phosphate al

89 This process consists of an initial aldol reaction catalyzed by readily available l-histidin

90 tudies on several key steps, namely a direct aldol reaction catalyzed by the dinuclear zinc ProPhenol

91 The sources of asymmetric induction in aldol reactions catalyzed by cinchona alkaloid-derived a

92 The transition states of aldol reactions catalyzed by vicinal diamines are charac

93 d product forms a tricyclic derivative under aldol reaction conditions, which can be a potential prec

94 nti-allylic alcohols using a catalytic Evans aldol reaction conjoined with a relay-type ring-closing

95 ther not so commonly used processes (such as aldol reactions, cyclizations, and isomerizations) will

96 reaction of the enolate to the other enone, aldol reaction, dehydration, and enamine formation will

97 chiral auxiliary mediated asymmetric acetate aldol reaction, dianion addition, and base mediated cycl

98 The influence of resident stereocenters on aldol reaction diastereoselection has been examined in d

99 The novel auxiliary 3 for the anti-aldol reaction does not exhibit the ordinary basicity of

100 The unexpected retroaldol-aldol reaction during O-alkylation of a beta-hydroxy lac

101 ls-Alder reactions, conjugate additions, and aldol reactions employing these auxiliaries are now repo

102 lecular Suzuki reaction and stereocontrolled aldol reactions establishing the C19/C20 and C22/C23 ste

103 le starting materials and coupled through an aldol reaction followed by dehydration to afford stereos

104 termediate titanium enolate could undergo an aldol reaction followed by the intramolecular Schmidt re

105 s include a series of highly stereoselective aldol reactions followed by directed reductions to build

106 our propionate diastereoisomers combining an aldol reaction, followed by a stereoselective radical-ba

107 ough application of a tandem chain extension-aldol reaction, followed by CAN-mediated oxidative cleav

108 ved in the sequential process, the N-nitroso aldol reaction, followed by Michael addition.

109 Key steps include the Paterson-Aldol reaction for the rapid assembly of the carbonate 4

110 , lanthanide-catalyzed, asymmetric Mukaiyama aldol reactions for the synthesis of chiral beta-hydroxy

111 A subsequent alkylation or an aldol reaction furnished the disubstituted succinates wi

112 loyed as an asymmetric catalyst in Mukaiyama aldol reactions, generating enantioselectivities of up t

113 boron-mediated syn- and anti-stereoselective aldol reaction giving rise to various beta-hydroxyenones

114 , the site, diastereo-, and enantioselective aldol reaction has been elevated to the rarefied status

115 The directed aldol reaction has served as a fertile proving ground fo

116 Retro-aldol reactions have been implicated as the limiting ste

117 merisation, transfer-hydrogenation and retro-aldol reactions have emerged as relevant transformations

118 velopments in the area of aqueous asymmetric aldol reactions highlighting two fundamental directions-

119 By performing the aldol reaction in [Bmim]NTf(2) as a solvent, we report e

120 ficient methods for the asymmetric Mukaiyama aldol reaction in aqueous solution has received great at

121 in what can be considered an N-selective HNO-aldol reaction in up to quantitative yields.

122 oline catalysts carry out the intermolecular aldol reaction in water and provide high diastereoselect

123 nd then directly engaged in enantioselective aldol reactions in a one-pot reaction.

124 e single transition state model observed for aldol reactions in organic solvent, the nornicotine-cata

125 The mechanism of aldol reactions in pure water has been studied with dens

126 ng an organocatalytic cascade of Michael and aldol reactions in the presence of a chiral thiourea cat

127 , artificial catalysts designed and used for aldol reactions in water can be promising for the synthe

128 exible chiral catalysts for enantioselective aldol reactions in water, on water, and in the presence

129 a a highly diastereoselective boron-mediated aldol reaction/in situ reduction between ketone (S)-8 an

130 ous aldol reaction and a boron-mediated anti-aldol reaction influenced by remote stereocontrol.

131 ction of carbonyl or imine electrophiles and aldol reactions initiated via enone conjugate addition a

132 Primary enamine-mediated aldol reactions involve half-chair transition states wit

133 izing the 1,4-syn stereoselectivity of boron aldol reactions involving certain alpha-chiral methyl ke

134 es, and stereochemistries of amine-catalyzed aldol reactions involving enamine intermediates have bee

135 a Cu-catalyzed asymmetric O-nitrosocarbonyl aldol reaction is described.

136 iastereoselective solid-supported Evans' syn-aldol reactions is described, with aldol products being

137 The enantioselectivity in the aldol reactions is reversed if the reactions are carried

138 The Mukaiyama-aldol reaction, known to require much more active Lewis

139 Transition states for the intramolecular aldol reactions leading to the formation of hydrindanone

140 yde 22 was employed for formaldehyde in this aldol reaction, leading to the beta-hydroxy aldehyde 20

141 ave been shown to be effective in catalysing aldol reactions, Morita-Baylis-Hillman reactions, conjug

142 is synthesis highlights a scalable Mukaiyama aldol reaction, Nicolaou-type epoxide opening reaction,

143 ay for the base-catalyzed reverse vinylogous aldol reaction of (-)-(4abeta,5beta)-4,4a,5,6,7,8-hexahy

144 ,3'-bioxindoles are constructed by Mukaiyama aldol reaction of 2-siloxyindoles with isatins.

145 An aldol reaction of 33 with the enolate of 55 prepared wit

146 In contrast, the aldol reaction of 6a and the chlorotitanium enolates of

147 was shown to promote enantioselective direct aldol reaction of 7-iodoisatin and 2,2-dimethyl-1,3-diox

148 tic system for the asymmetric direct crossed-aldol reaction of acetaldehyde in aqueous media using br

149 2 and 94 were (i) a Nagao asymmetric acetate aldol reaction of aldehyde 77 with thionothiazolidine 78

150 The Mukayiama aldol reaction of aldehydes is efficiently accomplished

151 The Mukaiyama cross-aldol reaction of alpha-fluoro-, alpha-chloro-, and alph

152 The aldol reaction of beta-allenoate with use of a commercia

153 The approach involves a Michael-aldol reaction of beta-keto sulfones with enones followe

154 led 1,5-syn and -anti stereoinduction in the aldol reaction of beta-tris(trialkylsilyl)siloxy methyl

155 lex as catalyst for the vinylogous Mukaiyama aldol reaction of bis(silyl) diendiolate 1 and an aldehy

156 had significantly increased activity for the aldol reaction of erythrose with pyruvate compared with

157 ons were achieved by a lithium-mediated anti aldol reaction of ester 40 and aldehyde 13 under Felkin-

158 C(24)), was established via a boron-mediated aldol reaction of ethyl ketone 15 and formaldehyde, foll

159 esigned serine-based organocatalyst promoted aldol reaction of hydroxyacetone leading to syn-diols.

160 Aldol reaction of hydroxybutanolide 31 with 2,4-hexadien

161 Aldol reaction of hydroxybutanolides 13b,c with 2,4-hexa

162 symmetric aminohydroxylation reactions or an aldol reaction of imidazolidinone 19.

163 base/Lewis acid catalysts in the asymmetric aldol reaction of isocyanoacetate nucleophiles.

164 A novel tandem bis-aldol reaction of ketone with paraformaldehyde catalyzed

165 equence is a transition metal/base-catalyzed aldol reaction of methyl isocyanoacetate and difluoroace

166 s a highly stereoselective fragment assembly aldol reaction of methyl ketone 4 and aldehyde 5 to esta

167 ynthesis features the highly stereoselective aldol reaction of methyl ketone 8b and aldehyde 60c and

168 r, has been achieved by employing Evans' syn-aldol reaction of N-acyl-(4R)-benzyl oxazolidin-2-one 3

169 An uncatalyzed aldol reaction of N-substituted thiazolidinediones with

170 een reduced to practice for catalysis of the aldol reaction of silyl ketene acetals and silyl dienol

171 he stereoselective intramolecular vinylogous aldol reaction of the furoic ester 25a to give 30 or its

172 The product of the aldol reaction of this aldehyde does not have a quenchin

173 e diastereoselectivity of the intramolecular aldol reaction of two differently sized monocyclic 1,3-d

174 o develop an efficient asymmetric vinylogous aldol reaction of unprecedented scope with respect to bo

175 The diastereoselectivities of aldol reactions of 2-methylpropanal with various enolate

176 nt of diastereo- and enantioselective direct aldol reactions of a broad range of substrates.

177 Enantioselective aldol reactions of acetophenone with beta,gamma-unsatura

178 Catalytic, enantioselective, directed cross-aldol reactions of aldehydes are described.

179 c is a very efficient catalyst for Mukaiyama aldol reactions of aldehydes with trimethylsilyl enolate

180 stereocontrol can be realized for enolsilane aldol reactions of beta-alkoxy and beta-silyloxy aldehyd

181 A study of the aldol reactions of boron enolates from methylketones tha

182 on the levels of 1,5-stereoselectivities of aldol reactions of boron enolates generated from beta-al

183 Aldol reactions of both the metastable dimer and the sta

184 The boron-mediated aldol reactions of certain types of beta-alkoxy methyl k

185 eloped by routes involving fragment assembly aldol reactions of chiral aldehyde 6a and the chiral met

186 range of beta-hydroxy ketones deriving from aldol reactions of chiral aldehydes with a variety of ch

187 beta-alkoxy ketones were derived from nitro-aldol reactions of chiral alkoxy aldehydes with a series

188 h diastereoselectivity relying on asymmetric aldol reactions of chlorotitanium enolates of N-propiony

189 ted from two complex reactions involving the aldol reactions of cyclohexanone with benzaldehyde or wi

190 the highest ee's obtained to date in direct aldol reactions of glycine equivalents catalyzed by inex

191 laldehyde, but cannot readily catalyze retro-aldol reactions of hexoses and pentoses at these moderat

192 ed by determining the stereoselectivities of aldol reactions of ketone 1a (known to give 3,5-trans al

193 or Horner-Emmons olefinations, and directed aldol reactions of lithium enolates), the one-pot proces

194 We also demonstrate aldol reactions of more demanding substrates with high a

195 rs that involves tandem Wittig rearrangement/aldol reactions of O-benzyl- or O-allylglycolate esters

196 gh trans- and syn-diastereoselectivities for aldol reactions of SF5-acetates with aldehydes in the pr

197 Furthermore, vinylogous aldol reactions of silyl dienol ethers are also demonstr

198 ed via substrate-controlled, boron-mediated, aldol reactions of the chiral ethyl ketones 10, 11, and

199 Aldol reactions of the corresponding anti aldehydes cont

200 Enabled by the highly stereocontrolled aldol reactions of three chiral ketone building blocks,

201 We conclude that the boron aldol reactions of unsubstituted boron enolates proceed

202 ate-temperature (around 100 degrees C) retro-aldol reactions of various hexoses in aqueous and alcoho

203 ach involving asymmetric Mannich-type (imino-aldol) reactions of methyl phenylacetate with N-tert-but

204 imental observation that the activity of the aldol reaction on mesoporous silica depends on the lengt

205 oes a catalyst-free stereoselective transfer aldol reaction on water.

206 rded aldehydes that underwent intramolecular aldol reactions on treatment with a NaOH solution to yie

207 combined with either a Sakurai reaction, an aldol reaction, or both is reported.

208 hetic utility of this chemistry, the racemic aldol reaction product was converted in five steps to a

209 Tandem intramolecular Sakurai-aldol reactions provide a concise and highly diastereose

210 A glycolate aldol reaction provided a diene useful for ring-closing

211 Alternatively, an aldol reaction provided access to the same analogue in a

212 syn-Selective aldol reactions realized by using either tertiary amines

213 een developed via asymmetric imino-aldol and aldol reactions, respectively, starting from protected a

214 ion of ketones and a tandem radical addition-aldol reaction sequence to access vicinal quaternary ste

215 cally controlled products via a domino aldol-aldol reaction sequence with excellent diastereoselectiv

216 feature a double diastereoselective acetate aldol reaction solely controlled by the chirality of the

217 fully intramolecular variant of the Sakurai-aldol reaction that creates four stereocenters, two new

218 ompounds was assembled via a stereoselective aldol reaction that unifies the C(1)-C(12) ketone fragme

219 erives from employment of diastereoselective aldol reactions that emanate from an 11 carbon piece.

220 This catalyst promotes aldol reactions that form rings containing 14 to 22 atom

221 e is a general lack of asymmetric vinylogous aldol reactions that tolerate variations of both the sil

222 rchetypical proline-catalyzed intramolecular aldol reaction, the Hajos-Parrish-Eder-Sauer-Wiechert re

223 reactivity and stereochemical selectivity in aldol reactions, the ability to catalyze Henry reactions

224 models for diastereoselective methyl ketone aldol reactions, the discovery of a spontaneous Horner-W

225 line esters are efficient organocatalysts of aldol reactions, these results permit to modulate asymme

226 metric induction usually observed in acetate aldol reactions, this is of great synthetic utility and

227 hat is useful for monitoring the progress of aldol reactions through an increase in fluorescence.

228 preparation are: (i) a stereoselective boron-aldol reaction to afford the acyclic carbon skeleton of

229 c system worked well in water for the direct aldol reaction to afford the products in excellent yield

230 o features an early-stage diastereoselective aldol reaction to assemble the substituted cyclopentanon

231 Synthetic highlights include a Crimmins aldol reaction to construct the C-1' and C-14 centers, a

232 construction of C13-C14 (Z)-olefin, acetate aldol reaction to construct the C6-C7 bond and install t

233 g to form the C15-C16 carbon-carbon bond, an aldol reaction to construct the C6-C7 carbon-carbon bond

234 C5-C11 polyol fragment, a diastereoselective aldol reaction to control the stereogenic center at C13,

235 urnish the CD-ring fragment, and a Mukaiyama aldol reaction to deliver the FG-ring fragment.

236 These two species are then reunited by an aldol reaction to form a new C-C bond, yielding an aldeh

237 alpha-ketol rearrangement, and a late stage aldol reaction to furnish the complex cage-like framewor

238 d as chiral auxiliary for asymmetric acetate aldol reaction to generate initial chirality in the targ

239 he C-1' and C-14 centers, a Crimmins acetate aldol reaction to generate the hydroxy group at the C-13

240 The cyclobutanols readily undergo retro-aldol reaction to give delta-ketoesters.

241 ed in a stereoselective MgBr2-catalyzed anti-aldol reaction to install the required stereochemistry o

242 nthesis include a stereoselective vinylogous aldol reaction to introduce the unusual dichloromethyl s

243 dinuclear Zn-catalyzed asymmetric glycolate aldol reaction to prepare the syn 1,2-diol, and an intra

244 lyst provides an optimum environment for the aldol reaction to proceed selectively in water, and the

245 pro-adapter undergoes a 38C2-catalyzed retro-aldol reaction to produce the vinylketone linker, which

246 sulfonimide, which undergoes Sn(II)-mediated aldol reactions to diastereoselectively afford the anti,

247 This strategy relies on two aldol reactions to install the chiral centers at C3/C4 a

248 reoselective, dialkylboron chloride-mediated aldol reactions to produce the anti,anti-aldol adduct.

249 actonization, ozonolysis, and intramolecular aldol reaction) to a spiro lactone cyclopentenal.

250 ned for their ability to catalyze an aqueous aldol reaction under buffered conditions.

251 minor nicotine metabolite, can catalyze the aldol reaction under physiologically relevant conditions

252 cco and metabolite of nicotine, can catalyze aldol reactions under aqueous conditions.

253 eta-hydroxy alpha-amino acids via asymmetric aldol reactions under homogeneous conditions.

254 lyst has been developed for asymmetric cross-aldol reactions under neat conditions in ketone-ketone,

255 hexene inhibitor that features an asymmetric aldol reaction using a titanium enolate, diastereoselect

256 been accomplished through an unexpected anti aldol reaction using a titanium-mediated process.

257 An organocatalytic enantioselective aldol reaction using paraformaldehyde as C1-unit has bee

258 ploying asymmetric alkylation and asymmetric aldol reactions using chiral oxazolidinones as the key s

259 ctive lysine, 38C2 catalyzes aldol and retro-aldol reactions using the enamine mechanism of natural a

260 see text] Double diastereoselective acetate aldol reactions using the N-acetyl thiazolidinethione-ba

261 glyceraldehyde in situ from glycerol for the aldol reaction, using galactose oxidase catalyzed oxidat

262 Moreover, a related aldol reaction was also developed.

263 reoselectivity of the tandem chain-extension-aldol reaction was determined through application of a C

264 A salen-Al-catalyzed aldol reaction was employed to construct a chiral oxazol

265 An intramolecular L-proline-mediated aldol reaction was employed to generate the cis-configur

266 The dominant product of the asymmetric aldol reaction was the non-Evans syn adduct as determine

267 sis of the transition states involving these aldol reactions was performed utilizing DFT (density fun

268 electivity in Lewis-acid-catalyzed Mukaiyama aldol reactions was studied using density functional the

269 Asymmetric aldol reactions were conducted with the titanium enolate

270 (cat) values of the antibody-catalyzed retro-aldol reactions were correlated with the K(d) values, i.

271 Four vicinal diamine-catalyzed aldol reactions were examined.

272 Intramolecular 1,8-diketone aldol reactions were studied as a tool for the construct

273 Three boron aldol reactions were used to assemble the linear carbon

274 Boron-mediated aldol reactions were used to configure the three key fra

275 CBS reduction, and proline-catalyzed crossed-aldol reactions were utilized as key steps for the gener

276 re catalytically competent toward asymmetric aldol reactions, were selected as the catalytic unit.

277 zyme optimized to perform a multistep retrol-aldol reaction when engineered into a TIM barrel protein

278 mproved stereoselectivity was observed in an aldol reaction when using a Boc-protected amino aldehyde

279 is-tetrahydro-4-hydroxy-6-methyl-2-pyrone by aldol reaction with 2,4-hexadienal, epoxidation followed

280 combination of an asymmetric organocatalytic aldol reaction with a subsequent biotransformation towar

281 to an alkynone followed by an intramolecular aldol reaction with a tethered aldehyde to afford a cycl

282 The enolates undergo aldol reaction with an aldehyde present in the reaction

283 th subsequent silyl trapping and a Mukaiyama aldol reaction with aqueous formaldehyde.

284 an organocatalytic one-pot Michael addition-aldol reaction with cheap 2-cyclohexenone and phenylacet

285 t 8 was demonstrated in a chemospecific anti-aldol reaction with cinnamaldehyde.

286 egy is based on two key reactions: first, an aldol reaction with formaldehyde in order to introduce s

287 The resulting enzyme catalyses a reversible aldol reaction with high stereoselectivity and tolerates

288 The first involved a direct aldol reaction with hydroxyacetone, dihydroxyacetone, or

289 ates in a proline derivative-catalyzed cross aldol reaction with ketones.

290 reochemical features of the titanium enolate aldol reaction with several 3-azidoaldehyde substrates d

291 rated by reactive immunization, catalyze the aldol reaction with the efficiency of natural enzymes, b

292 HB were accepted as donors in FSA-catalyzed aldol reactions with a variety of azido- and Cbz-amino a

293 e (1) and characterization of representative aldol reactions with aldehydes and ketones.

294 tetrasubstituted enolborinates which undergo aldol reactions with aldehydes to form products with all

295 f aldolase antibodies that catalyze the same aldol reactions with antipodal selectivity were analyzed

296 ol-type reactions is the suppression of self-aldol reactions with enolizable aldehydes in reactions s

297 lyze both Mukaiyama-Mannich and oxocarbenium aldol reactions with high efficiency and enantioselectiv

298 Highly diastereoselective aldol reactions with s-trioxane were also achieved with

299 Aldol reactions with trifluoroacetophenones as acceptors

300 e been explored as donors in organocatalytic aldol reactions with various aldehyde and ketone accepto