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1 ologue in S. cerevisiae that also encodes an alkaline ceramidase.
2 e been accordingly called acid, neutral, and alkaline ceramidases.
3  Unbiased transcriptomic analysis identifies alkaline ceramidase 1 (ACER1), a key enzyme in sphingoli
4  that Ca2+(o) markedly upregulates the human alkaline ceramidase 1 (haCER1) in HEKs; and its upregula
5        haCER1 is the human ortholog of mouse alkaline ceramidase 1 that we previously identified.
6                        Herein we report that alkaline ceramidase 2 (ACER2) plays a key role in sustai
7                                        Human alkaline ceramidase 2 (ACER2) plays an important role in
8           Here we demonstrate that the human alkaline ceramidase 2 (ACER2), a Golgi enzyme, regulates
9 knockdown up-regulated the expression of the alkaline ceramidase 2 (ACER2), and the ACER2 up-regulati
10                                    The mouse alkaline ceramidase 2 gene (Acer2) is highly expressed i
11 demonstrate that our previously cloned human alkaline ceramidase 3 (ACER3) specifically controls the
12      This study investigates the function of alkaline ceramidase 3 (ACER3)-catalyzed hydrolysis of un
13 ve been identified: 1 acid, 1 neutral, and 3 alkaline ceramidases (ACER1, ACER2, and ACER3).
14                                     Not only alkaline ceramidase activity but also the generation of
15                  Instead, D-e-MAPP inhibited alkaline ceramidase activity in vitro with an IC50 of 1-
16               Here, we demonstrate that only alkaline ceramidase activity is expressed in erythrocyte
17                                              Alkaline ceramidase activity is highly expressed in mous
18     Collectively, these results suggest that alkaline ceramidase activity is important for the genera
19 onstrate that the yeast gene YPC1 encodes an alkaline ceramidase activity responsible for the breakdo
20 cloning of a cDNA encoding for a novel human alkaline ceramidase (aPHC) that hydrolyzes phytoceramide
21 ramidase inhibitor D-e-MAPP, suggesting that alkaline ceramidases have a role in the generation of SP
22      Brainwashing (Bwa) is the only putative alkaline ceramidase homologue present in Drosophila.
23         Several genes encode for variants of alkaline ceramidase in mammals.
24 e that D-e-MAPP functions as an inhibitor of alkaline ceramidase in vitro and in cells resulting in e
25  SPH and S1P increases were inhibited by the alkaline ceramidase inhibitor D-e-MAPP, suggesting that
26 loning and characterization of a novel mouse alkaline ceramidase (maCER1) with a highly restricted su
27                             Similar to other alkaline ceramidases, maCER1 had an alkaline pH optimum
28 The predicted protein product belongs to the alkaline ceramidase, PAQR receptor, Per1, SID-1, and TME
29 lkaline phytoceramidase, the first mammalian alkaline ceramidase to be identified as being specific f
30 and small interfering RNA knockdown of human alkaline ceramidase, which all increase endogenous ceram
31 accharomyces cerevisiae gene YPC1 encodes an alkaline ceramidase with a dual activity, catalyzing bot
32 r, these data suggest that maCER1 is a novel alkaline ceramidase with a stringent substrate specifici
33      Based on sequence homology to the yeast alkaline ceramidases YPC1p, we report the identification
34 s a 28 and 32% identity to the Saccharomyces alkaline ceramidases (YPC1p and YDC1p) and the human alk