ライフサイエンスコーパス: alkyne

1 a heterocycle, or an unprotected alcohol or alkyne.

2 ine arising from reaction with the analogous alkyne.

3 ous catalyzed hydrometalation of olefins and alkynes.

4 /hydroamination cascade of readily available alkynes.

5 catalystic steps from commercially available alkynes.

6 enzannulation through difunctionalization of alkynes.

7 catalysts reported for the hydroamination of alkynes.

8 nerated by reaction of B(C(6) F(5) )(3) with alkynes.

9 d hydroboration of a variety of nitriles and alkynes.

10 semi- and complete hydrogenation of terminal alkynes.

11 arylative radical annulation reactions with alkynes.

12 es by avoiding challenging isolation of free alkynes.

13 yl ylides with a wide variety of alkenes and alkynes.

14 versatile fragment coupling approach toward alkynes.

15 theses, giving access to a broad spectrum of alkynes.

16 -mediated oxidative 1,2-amino-oxygenation of alkynes.

17 old-catalyzed oxidative coupling of terminal alkynes.

18 dependencies, i.e., internal versus terminal alkynes.

19 he first trans phosphinoboration of internal alkynes.

20 conditions worked well with both alkenes and alkynes.

21 n as surrogates for p-substituted arenes and alkynes.

22 e synthesis via carbene transfer to internal alkynes.

23 Alkyne 1,1-carboboration, the Wrackmeyer reaction, is an

24 catalyzes the semihydrogenation of internal alkynes, 1,3-diynes and 1,3-enynes.

25 dical hydroindation, and palladium-catalyzed alkyne-1,2-bis-stannation.

26 10,11), cyano(12), diazo(13), alkene(14) and alkyne(15-17) groups, continue to be discovered in natur

27 We have unequivocally established that alkyne, 2-phenylpyridine, and water can facilitate hydro

28 on of a terminal alkene to a monosubstituted alkyne; (2) a catalytic S(N)2'- and enantioselective all

29 roups by catalyst-free hydrophosphination of alkynes (4 and 5).

30 yzed addition of terminal alkyne to acceptor alkyne, a Mukaiyama aldol reaction, a Yamaguchi esterifi

31 In the case of unsymmetrical alkynes, a highly regioselective product was obtained, w

32 hesis polymerization through their efficient alkyne addition reactions.

33 lead to silyl enol ethers after Cu-catalyzed alkyne addition using StackPhos as a ligand.

34 unctionality at position 2 of the adenine (2-alkyne adenosine or 2YnAd) is suitable for selective enr

35 vity of boron-based molecules with H(2), CO, alkynes, alkenes and even with N(2).

36 clocondensation of primary nitroalkanes with alkynes/alkenes to afford a library of isoxazole/isoxazo

37 Likewise, a palladium-catalyzed alkyne alkoxycarbonylation reaction with formation of an

38 Titanium alkoxide-based alkyne-alkyne reductive coupling mediated by in situ gen

39 that is used as a hydrocarbonation partner (alkyne, allene or alkene).

40 In polar media, it is rapidly followed by an alkyne-allene isomerization of the excited branch.

41 d-catalyzed reactions of specially activated alkynes, allenes, and alkenes.

42 gy for heterobifunctional electron-deficient alkynes allowing for facile functionalization of payload

43 a a molecular shuffling process involving an alkyne, an alpha,beta-unsaturated acid chloride, which s

44 spired approach the so-derived cytospolide D alkyne analogue has been further converted to bicyclic a

45 cycle-mediated intramolecular coupling of an alkyne and a 1,3-diketone can proceed with a highly func

46 ogues with ribose functionalized by terminal alkyne and azido groups.

47 l alkanes, alkane isomers, and alkane/alkene/alkyne and C(8) alkylaromatics, with a particular focus

48 one structure of Dlin-MC3-DMA by introducing alkyne and ester groups into the lipid tails.

49 eactant structure and coupling a hydrophilic alkyne and hydrophobic azide results in a more pronounce

50 The terminal alkyne and the subsequent propargyl/allenyl dianion were

51 tion and olefination of dimedone establishes alkyne and vinylarene functionality linked by a neopenty

52 , carbon monoxide (carbonylation of terminal alkynes and alkenes), and other substrates will be discu

53 should enable the further study of strained alkynes and allenes in chemical synthesis.

54 Silyl triflate precursors to cyclic alkynes and allenes serve as valuable synthetic building

55 he Au(I)-catalyzed reaction between terminal alkynes and aromatic haloalkynes proceeds through diverg

56 f acylimines (in situ formed) with activated alkynes and aromatic nucleophiles such as indoles, pyrro

57 served "uptake mode", binding small-molecule alkynes and azides inside a water-soluble amphiphilic po

58 were produced from simple alkyl-substituted alkynes and Bu(3)SnH in high yield and good regioselecti

59 While the metathesis reaction between alkynes and carbonyl compounds is an important tool in o

60 ic organic molecules, such as arynes, cyclic alkynes and cyclic allenes, have intrigued chemists for

61 ions, Ni@FAU showed remarkable adsorption of alkynes and efficient separations of acetylene/ethylene,

62 indicate the syn addition of Bu(3)SnH to the alkynes and imply the involvement of Sn-H bond activatio

63 nary stereocenters substituted with alkenes, alkynes and ketones.

64 for terminal alkenes, leaving even terminal alkynes (and other sites of unsaturation) untouched.

65 tary linker functionalities (i.e., azide and alkyne) and follow-up attachment of stopper groups provi

66 d functionalities, including ketone, alkene, alkyne, and nitro groups.

67 ailable materials, such as amines, activated alkynes, and activated alkenes.

68 he three-component cycloaddition of enoates, alkynes, and aldehydes has been developed.

69 rminal alkynes, dialkyl-substituted internal alkynes, and alkynes with electron-deficient substituent

70 nctional groups (including amides, nitriles, alkynes, and arenes) into the sp(3) -rich heterocyclic s

71 of alpha-keto aldehydes, anilines, activated alkynes, and aromatic nucleophiles is developed to synth

72 an electrochemical hydrogenation of alkenes, alkynes, and ketones using ammonia as the hydrogen sourc

73 -catalyzed addition of P-H bonds to alkenes, alkynes, and other unsaturated substrates in hydrophosph

74 romagnesiation of terminal alkenes, internal alkynes, and styrene derivatives, the underlying mechani

75 actions for the desymmetrization of alkene-, alkyne- and allene-tethered cyclohexadienones using tran

76 ed in terms of robust rhodaelectro-catalyzed alkyne annulations.

77 When 2 equiv of the alkyne are used, structurally complex benzo[ de]chromene

78 njugation reactions and reveal that strained alkynes are better reaction partners for achieving maxim

79 Moreover, silylated alkynes are shown to participate well in hydrogenative m

80 yanoethyne derivatives containing a tethered alkyne) are produced.

81 e organic compounds (e.g., alkanes, alkenes, alkynes, aromatics, carbonyls, and polycyclic aromatic h

82 ductive three-component coupling of terminal alkynes, aryl halides, and pinacolborane.

83 namide-SAM conjugate (named NS1) features an alkyne as a key design element that closely mimics the l

84 Using gem-difluoromethylene alkynes as effectors, unprecedented diverse C-H activati

85 ther, this work illustrates the potential of alkynes as latent electrophiles in small molecule inhibi

86 r accommodate a variety of internal aromatic alkynes as substrates for cyclopropenation with unpreced

87 opy, with the dissolved fluorescent dye (FAM-alkyne) as a control.

88 uggests that the enhanced reactivity of bent alkynes, as compared to linear C=C triple bonds, finds i

89 Three different modes of aldehyde/alkyne assembly through a controlled radical reaction ar

90 stalline steroid molecular rotor without the alkyne axle.

91 lead but still relied on the Cu(I)-catalyzed alkyne-azide [3 + 2] cycloaddition for conjugation onto

92 erforms highly efficient copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) reactions on both alk

93 ysteine and can be used for copper-catalyzed alkyne-azide cycloaddition (CuAAC) without further proce

94 for their reactivity toward strain-promoted alkyne-azide cycloaddition (SPAAC).

95 amenable to cluster-surface strain-promoted alkyne-azide cycloaddition chemistry with a strained cyc

96 ring-closing metathesis and copper-catalyzed alkyne-azide cycloaddition, peptide chemists embraced tr

97 pe thiol-ene addition and copper(I)-mediated alkyne-azide cycloaddition.

98 t to image the uptake and distribution of an alkyne-based drug in living cells.

99 Using an internal aliphatic alkyne bearing a propargylic ether group, different P411

100 tro-Brook rearrangement observed in terminal alkynes bearing a silyl ether moiety.

101 Methods: An alkyne-bearing precursor was synthesized and subjected t

102 Alkynes, branched 1,3-dienes, and bicyclic alkenes were

103 des a dinuclear complex in which an internal alkyne bridges two [Cp*RuCl] fragments.

104 dence that the copper catalyst activates the alkyne by hydrocupration, which controls both the regio-

105 -yielding Sonogashira coupling with volatile alkynes by avoiding challenging isolation of free alkyne

106 Gold-catalyzed oxidations of alkynes by N-oxides offer direct access to reactive alph

107 ilyl)acetylene Me3SiC2SiMe3 (mono-functional alkynes: C[triple bond, length as m-dash]C) in Cp'2M(eta

108 ctionalized molecules: Amines, alcohols, and alkynes can be attached onto the small malonate core uni

109 her a protected carbonyl or a functionalized alkyne, can be cyclized to the pyrrolodiketopiperazine b

110 Since the alkyne captures two trifluoromethyl groups from each mol

111 tructural features: tert-butyl wheels, short alkyne chassis, and combination sets of wheels including

112 de-bond formation or a Cu(I)-catalyzed azide-alkyne click (CuAAC) reaction for labeling an octreotide

113 synthesized, followed by a step-growth azide-alkyne "click" reaction between the 4th-generation diazi

114 catalytic cycles, such as gold(III) alkene, alkyne, CO and hydride complexes, and important catalysi

115 New electrophiles and their corresponding alkyne conjugates were profiled directly in cultured cel

116 between hydrogen bonding and protonation of alkynes connected, on one side, to various aromatic ring

117 The metal-free hydrofluorination of alkynes constitutes an attractive though elusive strateg

118 on of a unique pathway to produce a terminal alkyne-containing amino acid in the bacterium Streptomyc

119 Au complexes toward the polycondensation of alkyne-containing comonomers and heteroarene nucleophile

120 fic anchor points for the conjugation of any alkyne-containing payload of choice.

121 Alkyne coordination to Au(III) involves decoordination o

122 efficiency of the ruthenium-catalysed alkene-alkyne coupling reaction between readily available vinyl

123 In this work, zirconocene-mediated alkyne coupling was used as a dynamic covalent C-C bond

124 uble bond, boron substituents accelerate the alkyne coupling.

125 The transit from early cycloadditions and alkyne couplings as ring-closing steps to very recent 3d

126 assembled through silver-catalyzed internal alkyne cyclization, and one-pot C-O bond cleavage/C-N bo

127 broad utility via the Cu(I)-catalysed azide-alkyne cycloaddition 'click' reaction(18).

128 that remain challenging to prepare by azide-alkyne cycloaddition (AAC, CuAAC, RuAAC) methods and can

129 ity as ligands in copper-catalyzed azide and alkyne cycloaddition (CuAAC) reactions were studied.

130 ation reactions using copper-catalyzed azide alkyne cycloaddition (CuAAC) this is not the case.

131 generated in situ by copper-catalyzed azide-alkyne cycloaddition (CuAAC), providing interpenetrating

132 nto photoinitiated copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC)-based networks.

133 opper determination by Cu(I)-catalyzed azide/alkyne cycloaddition (CuAAC).

134 via the bioorthogonal strain-promoted azide alkyne cycloaddition (SPAAC).

135 nylalanine via the copper(I)-catalyzed azide-alkyne cycloaddition can increase the conformational sta

136 thogonal hydrazide and copper-assisted azide-alkyne cycloaddition conjugation chemistries were employ

137 -like catalysis of the copper-mediated azide-alkyne cycloaddition reaction.

138 gen heterocycles was demonstrated with azide-alkyne cycloaddition to N-bromotetrafluoroethyl 1,2,3-tr

139 domethylpyrene by the copper-catalyzed azide-alkyne cycloaddition.

140 n is orthogonal to the strain-promoted azide-alkyne cycloaddition.

141 hat are synthesized by Cu(I)-catalyzed azide-alkyne cycloaddition.

142 catalyst location on copper-catalyzed azide-alkyne cycloadditions which drive the self-reproduction

143 solid state and diverted reactivity towards alkyne cyclotrimerization.

144 exhibited saturation-like behavior, whereas alkyne demonstrated a complex dependency; rate inhibitio

145 Terminal alkynes, dialkyl-substituted internal alkynes, and alkyn

146 Terminal alkyne diethyl ethynylphosphonate reacted with ketones t

147 vely promoting the noncopper catalyzed azide-alkyne dipolar cycloaddition click reaction between eith

148 cinol derivatives with terminal and internal alkynes directed by picolinamide auxiliary has been deve

149 Bulky photolabile masked alkyne equivalents (MAEs) are needed for the synthesis o

150 unctionalities, including nitriles, alkenes, alkynes, esters, and ketones.

151 Current approaches to introduce terminal alkynes for bioorthogonal reactions into biomolecules st

152 We used triisopropyl silane-substituted alkynes for the alkynylation reaction, which can easily

153 w that an adenosine analogue with a terminal alkyne functionality at position 2 of the adenine (2-alk

154 Furthermore, a terminal alkyne functionality is frequently introduced in chemica

155 Indole sulfides with internal alkyne functionality produced 2H-[1,3]thiazino[3,2-a]ind

156 Here we report a gram-scale synthesis of an alkyne-functionalized expanded [11]helicene and its sing

157 Highly efficient oxidative annulation of alkynes furnished diversely substituted pyran[2,3,4- de]

158 alpha-silylaryl triflates, Schiff bases, and alkynes generated polysubstituted pyrroles in good yield

159 ubstituted alkene equivalents to couple with alkynes, generating various boryl-substituted homoallyli

160 analog of puromycin that contains a terminal alkyne group, has facilitated the quantification of prot

161 ,6-Cl(2)C(6)H(3)) forms upon reaction of the alkyne H-C=CAr with the copper(II) tert-butoxide complex

162 ionalization of benzylic substrates R-H with alkynes H-C=CR' (R' = (hetero)aryl, silyl) that provide

163 n of alpha,beta-unsaturated oxime ether with alkyne has been reported.

164 In particular, the terminal alkyne has found broad utility via the Cu(I)-catalysed a

165 e ruthenium catalytic addition of alkenes to alkynes has been demonstrated as a powerful synthetic to

166 AHs) from readily available aryl ketones and alkynes has been disclosed.

167 yzed spiroannulation of 4-bromocoumarin with alkynes has been illustrated.

168 ndole frameworks from 3-indolylmethanols and alkynes has been reported.

169 ctive catalysts for ortho-hydroarylations of alkynes have previously been reported to result from act

170 tructurally different alkenes, along with an alkyne, have been utilized as dienophiles to afford a wi

171 m-dash]C, SiH) and alpha-di-SiH-substituted alkynes (hetero-tri-functional: SiH, C[triple bond, leng

172 several functional groups including terminal alkyne, heterocycle through click reaction, and others.

173 action, followed by either an intramolecular alkyne hydroarylation and subsequent alkene isomerizatio

174 h competing inter- and intramolecular alkene/alkyne hydroboration.

175 This was quantified using alkyne hydrogenation and H-atom transfer reactions with

176 yhydric alcohols, selective hydrogenation of alkynes, hydrogenation of nitroaromatics, CO(2) hydrogen

177 demonstrating divergent regioselectivity for alkyne hydrostannylation controlled by Cu/Fe vs Cu/Mn pa

178 The efficient removal of alkyne impurities for the production of polymer-grade lo

179 the influence of the strained nature of the alkyne in their structures as well as the size of the sy

180 The challenging annulations of two different alkynes in a regioselective fashion have been demonstrat

181 ic dipole class, the electrophilicity of the alkynes in SNO-OCTs can be manipulated to achieve diverg

182 a concurrent oxidation of both aldehydes and alkynes in the course of their connection offers aroylox

183 c monomer (M) was prepared with two terminal alkynes in the outer rim for polymerization, and two ter

184 oformylation of a large range of alkenes and alkynes, including sensitive starting materials.

185 ns were suitable for a diverse collection of alkynes, including several highly functionalized pharmac

186 ey reactions involved in this annulation are alkyne insertion and aza-Michael addition under oxidant-

187 ed route to a truncated analogue carrying an alkyne instead of the natural n-pentyl side chain has be

188 ermediates from benign and readily available alkynes instead of hazardous diazo carbonyl compounds.

189 upported by Y, Lu, and La form the Ni(eta(2)-alkyne) intermediate, (eta(2)-PhC=CPh)Ni((i)Pr(2)PCH(2)N

190 conversion of Meldrum's acid derivatives and alkynes into delta-lactones.

191 he reaction of a Lewis acidic borane with an alkyne is a key step in a diverse range of main group tr

192 As a result, every time a chain end alkyne is activated, rapid intermolecular reaction takes

193 In contrast, a sulfonyl, ester-substituted alkyne is reactive enough that it couples with an azide

194 Of these, an analog in which the EFV alkyne is replaced with an alkene and an analog in which

195 tly discovered gem-hydrogenation of internal alkynes is a fundamentally new transformation, in which

196 rential dihydrofunctionalization of terminal alkynes is accomplished through the reductive three-comp

197 ion of N-methoxybenzamides with two distinct alkynes is also demonstrated.

198 ether or thioether) with electron-deficient alkynes is induced by UV or visible light.

199 direct conversion of alpha-hydroxyketones to alkynes is reported.

200 ed a specific bioorthogonal probe, itaconate-alkyne (ITalk), for quantitative and site-specific chemo

201 vo cellular production of halo-, alkene- and alkyne-labelled proteins and natural products from gluco

202 ion pathways for BrMn(CO)(5), e.g., terminal alkynes lead to the generation of Mn(I)-acetylide specie

203 cyclization involving a BOX-ZnI(2)-activated alkyne leads to the formation of various cyclopentenes i

204 ng bis-styryl-BTD were retained with a rigid alkyne linker rendering a probe insensitive to cis-trans

205 he short acene axes, in the direction of the alkyne linkers.

206 Separately, the inclusion of alkyne lipids significantly increases membrane fusion to

207 or small molecules (mero166, azide; mero167, alkyne; mero76, carboxylic acid).

208 ic derivatives: (1) a figure-eight dimer via alkyne metathesis (also gram scale) and (2) two arylene-

209 Ring-closing alkyne metathesis allowed a 13-membered cycloalkyne to b

210 ene) precursor prepared through ring-opening alkyne metathesis polymerization (ROAMP).

211 -defined molybdenum alkylidyne catalysts for alkyne metathesis, which is distinguished by a tripodal

212 This finding is used to create an alkyne-modified alphaCA, YY4-yne, that serves as a cellu

213 Using a single alkyne-modified metabolite and a solid-phase azide resin

214 Finally, we synthesized two alkyne-modified peptoids (PE8 and PE9), conjugated with

215 lar oxygen efficiently deprotonates terminal alkyne moieties of 1,3,5-tris(4-ethynylphenyl)benzene (E

216 Azide and alkyne moieties were specifically anchored onto desired

217 hances the interaction between InI(3) and an alkyne moiety and reduces the activation energy.

218 s not correlate with electrophilicity of the alkyne moiety, indicative of a proximity-driven reactivi

219 ort the multicomponent oxidative coupling of alkynes, nitriles, and Ti imido complexes for the synthe

220 lving those macrocycles having more strained alkynes not only are more exothermic and exhibit lower a

221 gged with a fluorescent dye or biotin to the alkyne of the analog, which can then be used to detect i

222 rmally triply bonded diplumbyne analogues of alkynes of the general formula ArPbPbAr (Ar = terphenyl

223 Metabolic labeling with alkyne-oleic acid (100 mum for 15 h) revealed that oleic

224 Here, competing reactions of a prochiral alkyne on Ag(111): two-dimensional (2D) homochiral Glase

225 Moreover, two fluorophores that include an alkyne or an azide group at the end of the alkyl chain a

226 Installment of tethered alkynes or azides onto the terephthalic phenolic hydroxy

227 Here we perform in vivo injection of alkyne- or azide-modified analogs of thymidine, uridine,

228 eeds via the attack of a thioaryl radical to alkyne over the activated Michael acceptor.

229 chemoselective hydroboration of nitriles and alkynes over other reducible functionalities for the fir

230 Metabolic labeling with alkyne-palmitic acid (100 mum for 15 h) also showed that

231 and the influence of the substituents on the alkyne part.

232 yethylene glycol linker, carrying a strained alkyne (PEG-BCN) and the second component is the azide-f

233 NPs were prepared by click reaction using an alkyne-PEG-neridronate linker.

234 and chemoselective transformations in which alkynes played a major role in reducing step count.

235 s on the aromatic ring at both propargyl and alkyne positions.

236 on Bronsted acid promoted benzannulation of alkyne precursors prepared by palladium-catalyzed cross-

237 es are unsatisfactory coupling partners with alkynes, presumably due to the increased steric hindranc

238 tes to BF(3)-activated aldehydes followed by alkyne-Prins cyclization, Friedel-Crafts reaction, and f

239 extended through the formation of bis(eta(2)-alkyne)Pt(0) complexes.

240 t-free coupling with isoquinolines, alkenes, alkynes, pyrazoles, and purines with typically high regi

241 es [Tp'(CO)(2)M=Si-M(CO)(2)(PMe(3))Tp'] with alkynes R(1)C=CR(2) and were comprehensively analyzed by

242 d) alkyne vibration compared to conventional alkyne Raman probes.

243 polydiacetylenes with intrinsic ultrastrong alkyne Raman signals that locate in this region for orga

244 yleneamine groups by exploiting its terminal alkyne reactivity with common organic electrophiles.

245 achieve reductive 1,1-difunctionalization of alkynes remains an important, but largely unaddressed, s

246 atalyze the coupling of boronic acids and/or alkynes, representative multi-site metal-catalyzed react

247 lso evaluated: the Sonogashira coupling with alkynes resulted in unsymmetrically substituted triazole

248 nent coupling of Ti imidos with nitriles and alkynes, ring opening of 2-imino-2H-azirines, or direct

249 ic support is viable for promoting selective alkyne semihydrogenation.

250 Unexpectedly, aryl groups conjugated to the alkyne significantly retard the reaction rate.

251 osilylation reaction of internal symmetrical alkynes, silicon electrophiles, and primary alkyl zinc i

252 a strain-promoted cycloaddition of azides to alkynes (SPAAC) strategy.

253 trans-selective cyanoboration reaction of an alkyne, specifically a 1,3-enyne, is described.

254 1.0 to 2100 between the slowest and fastest alkynes studied.

255 Herein, we investigate the effects of alkyne substitution on the rate of this reaction, both e

256 Our results enable the explanation of alkyne substrate dependencies, i.e., internal versus ter

257 ed strategy is effective for a wide range of alkyne substrates such as terminal- and internal alkynes

258 the development of an analogous method with alkyne substrates.

259 geraniol using allylic functionalization and alkyne synthesis.

260 R tags, fluorescent tags, affinity tags, and alkyne tags, to proteins.

261 ethoxy migration is clearly defined when the alkyne terminus is phenylated.

262 The unreactivity of the alkyne terminus not bearing a phenyl ring is because the

263 by the existence of the phenyl group on the alkyne terminus.

264 so applicable to the cyclization of internal alkyne-tethered N-propargylic beta-enaminones.

265 ation of an activated copper complex, so any alkyne that is activated by copper reacts rapidly with t

266 yzed-1,3-dipolar cycloaddition of azides and alkynes (the CuAAC or "click" reaction) as the protocol

267 y, secondary, and tertiary alkyl-substituted alkynes, thus demonstrating divergent regioselectivity f

268 opening, a Pd-catalyzed addition of terminal alkyne to acceptor alkyne, a Mukaiyama aldol reaction, a

269 tion depend on the relative concentration of alkyne to imine.

270 eeds first with the coordination of Au(I) to alkyne to initiate the reaction with 1,5-H shift as a ra

271 lace via nucleophilic attack of the terminal alkyne to the C2 carbon of the activated haloalkyne, ass

272 ctance of the gold(I)-catalyzed oxidation of alkynes to 1,2-dicarbonyls in the absence of any acid ad

273 zirconium-catalyzed hydroaminoalkylation of alkynes to access alpha,beta,gamma-substituted allylic a

274 for the regioselective hydrofluorination of alkynes to access both the E and Z isomers of vinyl fluo

275 [2,3-b]pyridin-1-yl)benzamides with internal alkynes to afford N-isoquinolono-7-azaindole via the for

276 + 2] cycloaddition reactions with different alkynes to generate 1,2-oxaphosphete ions, which were is

277 onditions was validated for dioxygenation of alkynes to highly demanding labile synthons, 1,2-diketon

278 en readily available vinyl boronic acids and alkynes to provide unsymmetrical 3-boryl-1,4-diene reage

279 henium-catalyzed semihydrogenation of diaryl alkynes to the corresponding E-alkenes has been achieved

280 the catalytic hydrostannylation of terminal alkynes under mild conditions, with Markovnikov/anti-Mar

281 electivity was observed for aryl-substituted alkynes under the Cu/Fe-catalyzed conditions, affording

282 silver-catalyzed hydroalkylation of terminal alkynes, using alkylboranes as coupling partners.

283 ective intramolecular Type II cyclization of alkynes via C-C activation of cyclobutanones.

284 s significantly enhanced (up to ~10(4) fold) alkyne vibration compared to conventional alkyne Raman p

285 Using click chemistry, Alexa Fluor 647 DIBO Alkyne was conjugated to palmitic acid.

286 yze the cis haloalkynylation of the terminal alkyne, whereas introduction of a weakly basic triflate

287 occurred only in the presence of coordinated alkyne, which suggests operation of a concerted metalati

288 nitriles in the presence of strained alkenes/alkynes, which allows for the orthogonal labeling of thr

289 more effective for less-reactive alkenes and alkynes, why a large excess of TMSCF(3) (1) is required

290 tended to pyridine synthesis by replacing an alkyne with a nitrile.

291 adical carbo-cyclization/gem-diborylation of alkynes with a high functional group tolerance is presen

292 l ketones via oxidative coupling of terminal alkynes with benzoquinones is reported.

293 s, dialkyl-substituted internal alkynes, and alkynes with electron-deficient substituents were found

294 Various internal alkynes with electron-withdrawing and electron-donating

295 of iPr(3)SiC=CX (X = H, Cl) across internal alkynes with formation of 1,3-enyne or 1-chloro-1,3-enyn

296 tool in organic synthesis, the reactivity of alkynes with isoelectronic main-group R(2)E=O compounds

297 It permits isomerization of alkynes with nonacidic alpha-C-H bonds and hence offers

298 he union of N-alkylamines and trimethylsilyl alkynes, without the presence of an external oxidant and

299 ne substrates such as terminal- and internal alkynes, ynamides, alkynyl ethers/thioethers, and even u

300 compound resulted in the isolation of a bis(alkyne) zirconocene complex instead(6).