ライフサイエンスコーパス: alkynyl

1 ycals along with various nucleophiles (aryl, alkynyl).

2 via nucleophilic attack of the amide N(-) to alkynyl.

3 of a series of compounds belonging to the 5-alkynyl-1,2,3-triazole family that exhibits potent antil

4 ydes or ketones is shown to give access to 2-alkynyl-1,3-diols in a stereoselective manner.

5 Interestingly, N-Boc-2-alkynyl-1-amino-3-yn-2-ols 6, bearing an additional alky

6 Under the same conditions, N-Boc-2-alkynyl-1-amino-3-yn-2-ols were converted into the corre

7 The synthesis of novel (omega-alkynyl-1-hydroxy-1,1-diyl)bisphosphonic acid tetramethy

8 We showcase 2-Substituted-Alkynyl-1-Sulfonyl Fluorides (SASFs) as a new class of c

9 The formation of alkynyl 11-hydroxy-8,9-epoxy-eicosatrienoic acid compare

10 as alkynyl 11-hydroxy-eicosatetraenoic acid, alkynyl 11-hydroxy-8,9-epoxy-eicosatrienoic acid, and al

11 The products were identified as alkynyl 11-hydroxy-eicosatetraenoic acid, alkynyl 11-hyd

12 ion into the Rh(II)-catalyzed reactions of 2-alkynyl 2-diazo amido-substituted esters.

13 the intramolecular heterocyclization of 2-(1-alkynyl)-2-alkene-1-ones and facilitates high levels of

14 xides for the synthesis of enantioenriched 2-alkynyl-2-arylcyclohexanones and 2,2-diarylcyclohexanone

15 had previously been found with a series of 2-alkynyl-2-diazo-3-oxobutanoates.

16 )-catalyzed cyclization of N-Boc-protected 6-alkynyl-3,4-dihydro-2H-pyridines, prepared by the Sonoga

17 (1H)-one (EBX) to afford a wide variety of 3-alkynyl-3-alkyl/aryl 2-oxindole under transition-metal f

18 3-Alkynyl-3-hydroxyisoindolinones react with hydrazine and

19 two novel transformations of 3-vinyl- and 3-alkynyl-3-hydroxyisoindolinones.

20 s the straightforward synthesis of various 2-alkynyl-3H-imidazo[4,5-b]pyridines, a valuable scaffold

21 o-(1,3-butadiynyl)phenyltriazene produced 3-alkynyl-4-bromocinnoline.

22 thesize a new metabolic chemical reporter, 6-Alkynyl-6-deoxy-GlcNAc (6AlkGlcNAc), for the identificat

23 ross-coupling of ortho-[2-(4-methoxylphenyl)-alkynyl]acetophenones with ortho-alkynylbenzaldehydes af

24 benzofuropyridines 8a-p by the reaction of o-alkynyl aldehyde 4a-t and 5a-p with tert-butylamine 6 un

25 Alkenyl aldehydes did not react, but an alkynyl aldehyde gave a 71% yield and 95% ee of an aziri

26 catalyzed aldol condensation reaction of an alkynyl aldehyde was also successfully achieved.

27 and naphthyridines 6a-v by the reaction of o-alkynyl aldehydes 3a-aa with amines having embedded nucl

28 s a facile conversion of easily accessible o-alkynyl aldehydes into medicinally useful heterocycles i

29 Accordingly, aryl, heteroaryl, alkynyl, alkenyl, allyl, or alkyl ketones that contain a

30 ifications afforded three organic cages with alkynyl, alkenyl, and alkyl edges, respectively.

31 Starting from aryl-, heteroaryl-, alkynyl-, alkenyl-, and alkyltrifluoroborates, a library

32 atic alkynes couple with various substituted alkynyl/alkenyl boronates/boronic acids by this procedur

33 In particular, alkynyl alkyl ketones resolve the long-standing problem

34 studies is applied to iron-SciOPP catalyzed alkynyl-alkyl cross-couplings, providing the first detai

35 lkyl, alkyl-alkyl, aryl-aryl, alkenyl-alkyl, alkynyl-alkyl) coupling partners.

36 oxidation of aryl-, silyl-, and alkyl-capped alkynyl alpha-cyano alkanone systems to the correspondin

37 The reaction utilizes branched vinyl or alkynyl alpha-fluoro ketones that can be coupled with a

38 eacts with terminal alkynes to give the [Zr]-alkynyl/ammonium systems 19.

39 itions for (i) metabolic incorporation of an alkynyl analog of palmitic acid into cellular proteins c

40 quantify the cellular targets labeled by the alkynyl analogue of HNE (aHNE).

41 The C2-alkynyl analogue was found to have double- to single-dig

42 The mu-alkynyl and mu-triazolide complexes undergo reversible r

43 affinities agreed with predicted binding of alkynyl and triazole analogues.

44 14R computationally, two alternatives, i.e., alkynyl and triazolyl derivatives, were identified.

45 c acids to the corresponding alkyl, alkenyl, alkynyl, and (hetero)aryl halides.

46 oupling reactions between aromatic, alkenyl, alkynyl, and alkyl substrates in library or individual f

47 n of alpha-quaternary centers bearing allyl, alkynyl, and heteroaryl groups in an umpolung fashion.

48 means of Sonogashira reaction, a series of 2-alkynyl- and 2,7-dialkynyl derivatives of 1,8-bis(dimeth

49 in D analogues, we identified a new class of alkynyl- and alkenyl-substituted macrolides with activit

50 bon bond forming methodology using potassium alkynyl- and alkenyltrifluoroborate salts has been devel

51 Aryl-, heteroaryl-, alkenyl-, alkynyl- and alkyl-substituted allylic phosphates may th

52 Aryl-, heteroaryl-, alkenyl-, alkynyl-, and alkyltrifluoroborates were converted into

53 /Ir-photoredox dual catalytic N-arylation of alkynyl anilines under continuous flow conditions with a

54 erall, omega-alkynyl linoleic acid and omega-alkynyl arachidonic acid appear to be metabolically comp

55 of arachidonic acid may limit the utility of alkynyl arachidonic acid in the tracking of cyclooxygena

56 ons of omega-alkynyl linoleic acid and omega-alkynyl arachidonic acid were compared to that of linole

57 d when omega-alkynyl linoleic acid and omega-alkynyl arachidonic acid were reacted with lipoxygenase

58 ze alkynyl linoleic but efficiently oxidized alkynyl arachidonic acid.

59 Other than thiolate and phosphine ligands, alkynyls are also briefly discussed.

60 shown compatibility with alkyl, alkenyl, and alkynyl, aromatic, and several heteroaromatic substituen

61 The reaction of alkyl sulfinates with alkynyl(aryl)iodonium salts provides a facile access int

62 ganometallic reagents includes alkyl, allyl, alkynyl, aryl, and heteroaryl compounds including those

63 Alkyl-, alkenyl-, alkynyl-, aryl- or heteroaryl-substituted trifluoromethy

64 use of those with large bite angles leads to alkynyl azacycles, with high stereoselectivity.

65 An alkynyl azide analogue of 1, which may be useful as a gl

66 The electrophilic cyclization of 2-(1-alkynyl)benzamides affords high yields of cyclic imidate

67 - t-Bu mediated iodoaminocyclization of 2-(1-alkynyl)benzamides is reported.

68 ves formation of the (E)-1-(2-nitrovinyl)-2-(alkynyl)benzene species 2 via condensation of synthon 1

69 developed for the synthesis of a variety of alkynyl benzenes and heteroarenes in good to excellent y

70 scopy of bacteria challenged with two of the alkynyl-benzimidazoles revealed changes in the cellular

71 inhibitor A22 in combination with one of the alkynyl-benzimidazoles was synergistic against Acinetoba

72 lective 5-exo- and 6-endo-cyclizations of an alkynyl benzothioamide have been achieved.

73 Herein, we report on the discovery of new alkynyl benzoxazine and dihydroquinazoline moieties capa

74 ive Hiyama cross-coupling, are accessed from alkynyl benzyldimethylsilanes featuring adjacent allylic

75 organocatalytic asymmetric approach to beta-alkynyl-beta-amino acids with high efficiency and practi

76 III)-catalyzed intramolecular coupling of 2'-alkynyl-biphenyl-2-carbaldehydes.

77 itive coverage remained unchanged in the A22-alkynyl bisbenzimidazole combination.

78 outer membrane was a significant barrier for alkynyl-bisbenzimidazole uptake.

79 cts the bicyclic guanidinium ion core from a alkynyl bisguanidine.

80 d to the development of potent and selective alkynyl bisubstrate inhibitors of NNMT.

81 ha-C-H bond of N-alkylamines into an alpha-C-alkynyl bond was developed.

82 The strain on the alkynyl bonds enabled a copper-free, three-fold azide-al

83 Simple as ABC: Alkynyl borane cycloadditions can be substrate-directed

84 tioselective approaches have been developed; alkynyl boronates add to glycolaldehyde imine to afford

85 ling of alkynyl bromide and pinacol ester of alkynyl boronic acid catalyzed by CuFe2O4 nanoparticles

86 s also extended for the Csp-Csp2 coupling of alkynyl bromide and alkenyl boronic acid to provide conj

87 An efficient Csp-Csp cross-coupling of alkynyl bromide and pinacol ester of alkynyl boronic aci

88 vated aryl chloride, alkenyl halides, and an alkynyl bromide) serve as suitable partners.

89 sted acids will catalyze the addition of the alkynyl C-H bond of phenylacetylene to the pincer comple

90 [Tp'Rh(PMe3)] was also able to activate the alkynyl C-H bond of terminal alkynes to give activation

91 A new peak at 2144 cm(-1) (alkynyl C=C stretch) was also detected in the decolorize

92 ut the need for an additive to deprotect the alkynyl carbon as endstanding anchor group.

93 C-N bond formation on the more electrophilic alkynyl carbon resulting in the formation of 6-endo-dig

94 C-N bond formation on the more electrophilic alkynyl carbon through 6-endo-dig cyclization.

95 N-C bond formation on the more electrophilic alkynyl carbon, resulting in the regioselective 6-endo-d

96 strategy allows direct access to chiral beta-alkynyl carbonyl compounds employing allylic alcohol sub

97 unds with alkynylstannanes to form secondary alkynyl carbonyl compounds via palladium catalysis emplo

98 tems, ynamides and their analogs, along with alkynyl carbonyl derivatives, are the classes of substra

99 c alkynylation of ortho-iodoallenamides with alkynyl carboxylic acids was studied.

100 l-lambda(3)-iodanes have been established as alkynyl cation equivalents for the alkynylation of carbo

101 ng than that for nucleosides carrying linear alkynyl chains.

102 of this unique modification, we developed an alkynyl chemical reporter for detection and identificati

103 e reaction between non-heteroatom-stabilized alkynyl chromium carbene complexes prepared in situ and

104 gen atom directed to the alkylidyne leads to alkynyl-cis-hydride-alkylidyne intermediates, which rapi

105 moieties has been realized using the Huisgen alkynyl click reaction, resulting in altered optical and

106 We report a homoleptic Au-Cu alkynyl cluster that represents an unexplored class of l

107 Studies of the mixed-valence mu-alkynyl complex's reactivity suggest that a mixed-valenc

108 A discrete, dicopper mu-alkynyl complex, [Cu2(mu-eta(1):eta(1)-C identical withC

109 gation of the gold-carbon bonding in gold(I)-alkynyl complexes using photoelectron spectroscopy and t

110 c material is the first example of a gold(I) alkynyl compound demonstrating vapochromic behavior.

111 pyrazole units by the reaction of alpha,beta-alkynyl compounds with hydrazine monohydrate, (iv) gold-

112 yclic species) synthetic routes to two novel alkynyl-conjugated multiple ferrocene- and biferrocene-c

113 h used (azido-COUPY/alkynyl-peptide resin or alkynyl-COUPY/azido-peptide resin).

114 e present work investigates this strategy in alkynyl crown ethers, where propargylic C-O bonds contai

115 nate ligand, the three-coordinate copper(II) alkynyl [Cu(II)]-C=CAr (Ar = 2,6-Cl(2)C(6)H(3)) forms up

116 nct stepwise on-surface reactions, including alkynyl cyclotrimerization, C-O bond cleavage, and C-H b

117 The metabolic labeling of cells with an alkynyl derivative of 20(S)-hydroxycholesterol has allow

118 functionalized bridged bicyclic systems from alkynyl diazoesters is presented.

119 and characterization of the mixed-valence mu-alkynyl dicopper complex, [Cu2(mu-eta(1):eta(1)-C identi

120 ular Diels-Alder reaction with an alkenyl or alkynyl dienophile.

121 les by heteroatom substitution and utilizing alkynyl dienophiles enhances the reaction rates up to 10

122 e effects of tether length, heteroatoms, and alkynyl dienophiles on reactivity were analyzed.

123 In the case of alkynyl dienophiles, [4 + 2] cycloaddition initially gen

124 ntramolecular 5-exo-dig cyclization of ortho-alkynyl diketopiperazines has been reported.

125 loisomerization reaction of boron-containing alkynyl epoxides toward C2- and C3-borylated furans has

126 te addition of alkyl groups to an alpha,beta-alkynyl ester intermediate, and differential activation

127 hus allows for rapid elaboration of the beta-alkynyl esters into a variety of chiral, substituted het

128 ew strategy for the synthesis of chiral beta-alkynyl esters which relies on sequential Pd and Cu cata

129 curs with high 1,4-selectivity yielding beta-alkynyl esters with excellent levels of enantioselectivi

130 In particular, use of alkynyl ether-tethered substrates led to (3 + 2) cycload

131 ith calculations on a carbon analogue of the alkynyl ether.

132 oretical calculation on the carboindation of alkynyl ethers to elucidate the effect of an alkoxy grou

133 ctive carboindation of terminal and internal alkynyl ethers using InI(3) and organosilicon or -stanna

134 ible toward a wide range of aryl-substituted alkynyl ethers with electron-donating and electron-withd

135 Substituted benzyl alkynyl ethers, prepared from the corresponding alpha-al

136 as terminal- and internal alkynes, ynamides, alkynyl ethers/thioethers, and even unsubstituted acetyl

137 ormal [8 + 2] cycloaddition reaction between alkynyl Fischer carbene complexes and tropothione leads

138 nstallation of diverse alkyl, alkenyl, aryl, alkynyl, fluoro, hydroxyl and amino groups at the beta p

139 cid (LNA) monomers, i.e. conventional and C5-alkynyl-functionalized LNA and alpha-L-LNA pyrimidine mo

140 gio- and enantioselective synthesis of gamma-alkynyl gamma-aminoalcohols via a silver-catalyzed propa

141 mplexes for the facile formation of terminal alkynyl-gold intermediates and activation of the carbon-

142 y, the effects of steric substitution of the alkynyl Grignard reagent on catalytic performance were i

143 e conditions with different aryl, alkyl, and alkynyl Grignard reagents.

144 ons and regioselective water addition to the alkynyl group at C-3 of the corresponding pyrrole-3-carb

145 ty of the allene double bond relative to the alkynyl group in allene-ynes.

146 emistry and shows the advantage of having an alkynyl group in the fourth coordination site on the met

147 We found that the alkynyl group not only enhances the oxidation stability

148 Utility is showcased by conversion of the alkynyl group to other useful functional units (e.g., ho

149 a reactions replace the Br-substituent by an alkynyl group, placed on the azaacene core.

150 high regioselectivities, placing alkenyl or alkynyl groups distal to the forming C-C bond.

151 The chemoselectivity of diazo and alkynyl groups enables dual labeling of cells that is no

152 ing/withdrawing aryl groups, silyl-protected alkynyl groups, as well as ferrocenyl and azulenyl group

153 les carrying aryl, 2-thienyl, 2-pyridyl, and alkynyl groups, in excellent yields using cross-coupling

154 alkyl, as well as alkenyl, aryl, allenyl and alkynyl groups.

155 of cells that is not possible with azido and alkynyl groups.

156 ids illustrated a general trend in porosity: alkynyl > alkenyl > alkyl.

157 ta-C(sp(3))-H bonds in aliphatic amides with alkynyl halides has been enabled using Pd(0)/N-heterocyc

158 enyne and an aldehyde or a ketone) using an alkynyl halo-Prins protocol.

159 In the first step, a multicomponent alkynyl halo-Prins reaction joins an enyne, a carbonyl d

160 The combination of a bis-alkynyl-helicene moiety with two iron centers leads to n

161 grees C) is required for aryl-heteroaryl and alkynyl-heteroaryl couplings.

162 dinate (Phen)R(3)PAu(I)NTf(2) complexes with alkynyl hypervalent iodine reagents was built.

163 regioselective [3 + 2] cycloadditions of the alkynyl-imides (ynimides) generate N,N-di-Boc imide-func

164 ion of in situ generated challenging N-Boc C-alkynyl imines from previously unreported C-alkynyl N-Bo

165 e catalytic asymmetric Mannich reaction of C-alkynyl imines that provide syn-configured propargylamin

166 hydroxyl allenes, and allyl boronates add to alkynyl imines to form 1,3-alkenyl allenes.

167 mmetric addition of carbon nucleophiles to C-alkynyl imines, culminating in a highly syn-selective ca

168 Reduction of alkynyl iminium salts derived from cyclic (alkyl)(amino)

169 has been demonstrated by using a series of 2-alkynyl indoles and arylacetylenes.

170 ne-pot reaction involving the treatment of 2-alkynyl indoles with arylacetylenes in the presence of a

171 ism involving an organometallic aryl-Co(III)-alkynyl intermediate species is preferred for terminal a

172 ]metacyclophanedienes (CPD) with alkenyl and alkynyl internal (8,16) groups is described together wit

173 Conversely, reversible alkynyl iodide oxidative addition generates bimetallic c

174 rmolecular oxidative addition of alkenyl and alkynyl iodides to Au(I) are reported.

175 observed for a variety of enantioenriched 1-alkynyl isochromans.

176 Alkynyl ketones are attractive but challenging nucleophi

177 (i) synthesis of pyrrole-derived alpha,beta-alkynyl ketones, (ii) introduction of various substituen

178 Alkynyl-lambda(3)-iodanes have been established as alkyn

179 ism of the Cp* complexes, while topology and alkynyl ligand electronics combine more subtly to drive

180 nylated iron(II)-SciOPP species due to rapid alkynyl ligand redistribution.

181 ure and SAR study revealed the ability of an alkynyl linker to span the methyl transfer tunnel of NNM

182 Bisbenzimidazoles with terminal alkynyl linkers likely impede bacterial growth by compro

183 tified the optimal combinations of azido and alkynyl linkers necessary for stapling BCL9 helices.

184 Bisbenzimidazoles with terminal alkynyl linkers, selective inhibitors of bacterial topoi

185 Overall, omega-alkynyl linoleic acid and omega-alkynyl arachidonic acid

186 y fatty acid products were formed when omega-alkynyl linoleic acid and omega-alkynyl arachidonic acid

187 nenzymatic and enzymatic oxidations of omega-alkynyl linoleic acid and omega-alkynyl arachidonic acid

188 Cyclooxygenase-1 and -2 did not oxidize alkynyl linoleic but efficiently oxidized alkynyl arachi

189 cal insight into the complex biochemistry of alkynyl lipid production.

190 T1, T3, and T4 have been completed using an alkynyl macrolactone as a common late-stage intermediate

191 lexes 1 are described in their reaction with alkynyl malonates.

192 provides access to highly useful chiral beta-alkynyl Meldrum's acid building blocks as demonstrated b

193 tment of three different isotopically edited alkynyl metabolic reporters.

194 a 1,3-dipolar cycloaddition reaction with an alkynyl-modified dye.

195 Herein we describe the development of an alkynyl-modified GlcNAc analog (GlcNAlk) as a new chemic

196 attractive approach for the incorporation of alkynyl moieties into organic molecules.

197 o, notably, to the silicon atoms of the four alkynyl moieties.

198 ran, whose substituents are derived from the alkynyl moiety (2-position), the imine (3- and 4-positio

199 The hydration of the alkynyl moiety (22 and 900 M(-1) s(-1)for QM-1 and QM-2,

200 pathway depending on the substitution of the alkynyl moiety.

201 -alkynyl imines from previously unreported C-alkynyl N-Boc-N,O-acetals, with alpha-substituted beta-k

202 In doing so, this work establishes 2'-alkynyl nitroxide spin-labelling as a minimally perturbi

203 ght into iron speciation and reactivity with alkynyl nucleophiles reported herein provides an essenti

204 ron-catalyzed cross-coupling reactions using alkynyl nucleophiles represent an attractive approach fo

205 wed the labeled substrates to be probed with alkynyl or azido-tagged fluorescent reporters by the cop

206 method is reported for the preparation of N-alkynyl or N-bromoalkenyl heteroarenes from bromoalkynes

207 ic acid while reagents bearing, for example, alkynyl or nitrophenyl moieties, hydrolyze extremely slo

208 For an alkynyl -OR substituent, the results strongly suggest a

209 etrasubstituted chrysenes bearing four aryl, alkynyl, or amino groups by means of the Suzuki, Sonogas

210 g with an aryl, a heteroaryl, an alkenyl, an alkynyl, or an alkyl substituent.

211 alkyl-, aryl-, heteroaryl-, allyl-, vinyl-, alkynyl-, or propargyl-metal reagents.

212 o a broad range of alkyl, aryl, alkenyl, and alkynyl organomagnesium, -zinc, -aluminum, or -boron rea

213 s to afford single geometric isomers of aryl alkynyl oxime ethers has also been developed.

214 m-catalyzed cascade annulation/allylation of alkynyl oxime ethers with allyl halides has been establi

215 e the regioselective epoxide ring-opening of alkynyl oxiranes and a stereoselective aza-Cope-Mannich

216 ce of a Cu(I) catalyst and a pyridine oxide, alkynyl oxiranes and oxetanes can be converted into func

217 two-step synthesis of a Cu-click compatible alkynyl oxoaldehyde probe (AlkMGO) via sequential Dess-M

218 spectroscopy to demonstrate that sulfonyl 3-alkynyl pantetheinamide is fully sequestered by the ACP,

219 e click chemistry approach used (azido-COUPY/alkynyl-peptide resin or alkynyl-COUPY/azido-peptide res

220 o cyclization of the resulting 2-nitro-1-(2-(alkynyl)phenyl)ethanol (6) to furnish iodo isochromene d

221 developed a new phosphoramidite synthon--the alkynyl phosphinoamidite, which is compatible with conve

222 ohydrazides 17a-17g rather than the expected alkynyl phthalazinones.

223 pproach are an asymmetric synthesis of the 2-alkynyl piperazine core via a base-promoted isomerizatio

224 -yl)-di-tert-butylphosphine) and the acetate alkynyl position from an aryl to vinyl substituent in th

225 tes with a pendant aryl group at the acetate alkynyl position were found to undergo preferential 1,3-

226 From the alkynyl precursor, the final helical compounds are obtai

227 inally unlabeled ((12)C identical with(12)C) alkynyl probe.

228 The resulting rhodium(III) bis(alkynyl) product can be trapped out by reaction with car

229 xy-8,9-epoxy-eicosatrienoic acid compared to alkynyl prostaglandins suggests that the omega-alkyne gr

230 1-hydroxy-8,9-epoxy-eicosatrienoic acid, and alkynyl prostaglandins.

231 An alkynyl-protected gold nanocluster [Au24(C identical wit

232 especially on (1) effective use of a series alkynyl protecting groups, (2) Sonogashira cross-couplin

233 he generalized use of quaternized vinyl- and alkynyl-pyridine reagents not only for bioconjugation, b

234 Quaternized vinyl- and alkynyl-pyridine reagents were shown to react in an ultr

235 indium reagents (R3In, R = aryl, heteroaryl, alkynyl) react selectively under palladium catalysis wit

236 nalization of AMPylation substrates with the alkynyl reporter in lieu of adenylyl 5'-monophosphate (A

237 d the regioselective introduction of various alkynyl residues at the C-2 position of pyrroles.

238 ging and visualization of glycoconjugates in alkynyl-saccharide-treated cells at extremely low concen

239 y means of 1,2-Zr/B FLP addition followed by alkynyl shift from boron to zirconium and reductive coup

240 chosen as the target amino acid because its alkynyl side chain can be selectively and efficiently co

241 Bisbenzimidazoles with alkynyl side chains display excellent E. coli DNA topois

242 transformations provided easy access to the alkynyl side-chain containing (2S,3R)-AHBAs.

243 e report the stereoselective synthesis of an alkynyl side-chain containing (2S,3R)-alpha-hydroxy-beta

244 The synthesis features a base-catalyzed alkynyl silane alcoholysis/ring-closing enyne metathesis

245 Extended organometallic honeycomb alkynyl-silver networks have been synthesized on a noble

246 mild annealing to 375 K, long-range ordered alkynyl-silver networks incorporating substrate atoms ev

247 leads to the scrambling of labels over both alkynyl (sp) carbons.

248 coordinate N,C-chelate organoboron dyes with alkynyl spacers were synthesized by Heck alkynylation.

249 Copper(II) alkynyl species are proposed as key intermediates in num

250 ls, silyl ketene imines, a silyl cyanide, an alkynyl stannane, and an allylic stannane were applicabl

251 More broadly, clickable alkynyl sterols may represent useful tools for sterol ce

252 d naphthalenes from easily accessible ortho-(alkynyl)styrenes under mild reaction conditions.

253 zation and intermolecular coupling of ortho-(alkynyl)styrenes with allylic alcohols catalyzed by PdCl

254 -indenes (from beta-alkyl-beta-alkyl/aryl-o-(alkynyl)styrenes) and 3-iodobenzofulvenes (from beta,bet

255 -iodobenzofulvenes (from beta,beta-diaryl-o-(alkynyl)styrenes) in good yields under mild reaction con

256 on the 5-endo iodocyclization reaction of o-(alkynyl)styrenes, represents one of the scarce examples

257 -1-amino-3-yn-2-ols 6, bearing an additional alkynyl substituent alpha to the hydroxyl group, spontan

258 2-dialkynyl-1,2-diols, bearing an additional alkynyl substituent at C-2, a cascade process, correspon

259 The alkynyl substituent favorably tunes catalyst solubility,

260 cal, generated from spiroepoxide 14, onto an alkynyl substituent generating tetracyclic compound 13 w

261 eful clues for predicting the effects of the alkynyl substituent on the nature of the key intermediat

262 solated yield depending on the nature of the alkynyl substituent.

263 nic and steric properties for three types of alkynyl substituents along the reaction paths and the im

264 ine monomers that are conjugated to small C5-alkynyl substituents induce significant improvements in

265 We describe here three alkynyl substituted naphthalenes that display promising

266 aryl-substituted acenes, photooxygenation of alkynyl-substituted acenes proceeds most likely by a con

267 ituted and aryl-, heteroaryl-, alkenyl-, and alkynyl-substituted homoallylic alpha-tertiary NH(2) -am

268 cade involves the addition of phenol-derived alkynyl substrates to BF(3)-activated aldehydes followed

269 anel of glycoproteins by click reaction with alkynyl sugar analogs in plasma cells coupled with mass

270 ACP dehydratase (DH) domains by means of a 3-alkynyl sulfone warhead.

271 s from ynoate-enoate, ynoate-enenitrile, and alkynyl sulfone-enenitrile substrates.

272 ess into otherwise difficult to obtain alkyl alkynyl sulfones and cyclic vinyl sulfones via 1,2-rearr

273 By using alkynyl sulfones or sulfonates as substrates, the oxidat

274 Alkynyl sulfoxides are important building blocks with a

275 This practical access to alkynyl sulfoxides is expected to facilitate the applica

276 A novel route to access alkynyl sulfoxides is reported herein by using ethynyl b

277 w methodology affords formation of alkyl and alkynyl surface monolayers of varied chain lengths (i.e.

278 Using alkynyl surrogates of O3-derived oxysterols, our data de

279 ly, supplementation of epithelial cells with alkynyl-tagged cholesterol followed by O3 exposure cause

280 An unstable, alkynyl-tagged curcumin analog yielded abundant adducts

281 st probable conductance value of a family of alkynyl terminated oligophenylenes (OPA(n)) connected to

282 nethiol, DNA) were successfully "clicked" to alkynyl-terminated BDD by irradiating the interface at 3

283 These alkynyl-terminated compounds permit the rapid and facile

284 in a functional-group tolerant manner using alkynyl thioethers.

285 drogen atom directed to the halide gives the alkynyl-trans-hydride-alkylidyne derivatives OsH(C ident

286 ic acid derivatives of para-substituted aryl-alkynyl triazacyclononane complexes are described.

287 The coordination chemistry of alkynyl triazenes and Cp*RuCl was studied and led to the

288 d cyclization proceeds well with both simple alkynyl triazenes and tethered 1-diynyl triazenes.

289 2 + 2 + 2] cyclotrimerization reactions of 1-alkynyl triazenes.

290 eaction of azide with a hypervalent iodonium alkynyl triflate and reacted in situ with 21 different c

291 coupling of hydroxyaldehydes or ketones with alkynyl trifluoroborate salts is reported.

292 tion of a sulfonylhydrazone that reacts with alkynyl trifluoroborates to generate a transient proparg

293 ble with substrates containing more than one alkynyl unit, cleanly affording compounds containing mul

294 The insertion of alkynyl units into the C-C bonds of polyhedranes results

295 njugates utilizing protein expressed with an alkynyl unnatural amino acid.

296 ycles by copper(II)-catalyzed cyclization of alkynyl ureas and secondary amides has been developed.

297 which the latter were previously limited in alkynyl zinc additions.

298 ions formed in situ followed by addition of alkynyl zinc complex to produce the propargylamine that

299 alladium catalyzed cross-coupling of methoxy alkynyl zinc reagents allows for the protecting-group-fr

300 2-promoted in situ formation of oxazolidine, alkynyl zinc, and propargylamine intermediates from 1-al