ライフサイエンスコーパス: allele frequency

1 lows detection of variant alleles below 0.1% allele frequency.

2 ignaling or to kill cells harboring a high K-allele frequency.

3 ionship between CWD prevalence and PRNP 132L allele frequency.

4 patients at levels as low as 0.002% variant allele frequency.

5 TERT(-146C>T) mutations present at different allele frequencies.

6 ome data and on somatic SVs with low variant allele frequencies.

7 ient and allele age from time series data of allele frequencies.

8 reported variants that had implausibly high allele frequencies.

9 e SNVs are prevalent at both rare and common allele frequencies.

10 SNV and indel detection at very low variant allele frequencies.

11 provide only summary statistics or aggregate allele frequencies.

12 -wide significance level regardless of minor allele frequencies.

13 ling simulations, which models data based on allele frequencies.

14 frequency 0.017) and rs116245325 (p.L1034F, allele frequency 0.0007) were associated with higher BP

15 ile the minor allele of rs61757359 (p.G541S, allele frequency 0.003) was associated with lower BP (P=

16 479618 (p.E967K, gnomAD non-Finnish European allele frequency 0.017) and rs116245325 (p.L1034F, allel

17 28 families with PIDs, with a variable minor allele frequency (0.8% to 40.5%).

18 Audit and Research, Tayside Scotland), minor allele frequency (=0.02), and randomized clinical trial

19 gle nucleotide polymorphism rs2571244, minor allele frequency = 0.08, P = 2.3 x 10-8).

20 or allele of the lead SNP (rs13417783, minor allele frequency = 0.14) decreased DPN odds by 36% (odds

21 s common among full-heritage Pima Indians (A allele frequency =0.54) but is monomorphic in the 1000 G

22 ic father and the rare NKX2-5 variant (minor allele frequency, 0.0012) from the unaffected mother.

23 UK biobank, where rs77059055 in TPM1 (minor allele frequency, 0.023; odds ratio, 0.83; P=0.002) rema

24 eatinine ratio (rs527493184 at ZBTB16, minor allele frequency=0.002, P=1.1x10(-8)).

25 ar filtration rate (rs58720902 at AQR, minor allele frequency=0.01, P=1.6x10(-8)) or urine albumin-to

26 ention Trial Evaluating Rosuvastatin], minor allele frequency=0.018) was used to replicate the associ

27 the TG response, we identified rs7350789-A (allele frequency=0.36), mapping to hepatic lipase (LIPC)

28 additional variant at PRNT (rs2422935, minor allele frequency=0.54, P=2.89x10(-8)) was significantly

29 le-nucleotide polymorphisms (SNP) with minor allele frequency 1%) to general cognitive function in a

30 ase-associated variants with relatively high allele frequency (1%-10%) in a nationwide Japanese cohor

31 After stringent filtering based on allele frequency, 1.4% of persons still had a candidate

32 s3211938 at CD36 was common in Blacks (minor allele frequency=10%), near monomorphic in European Amer

33 mericans, the X-linked G6PD G202A variant (T-allele frequency 11%) was associated with an absolute de

34 OR 1.37; 95% CI 1.21-1.56; P = 1.5 x 10(-6); allele frequency = 11.5%).

35 OR 1.62; 95% CI 1.32-1.98; P = 4.0 x 10(-6); allele frequency = 13.3%), but the polymorphism was asso

36 The mutation is extremely rare (allele frequency = 2.5 x 10-05), and the likelihood of t

37 dentified in CYP2R1 the low-frequency (minor allele frequency = 2.5%) synonymous coding variant g.149

38 ) that increased CAD activity and is common (allele frequency 20%) in African ethnicity.

39 orms all imputation approaches for all minor allele frequencies; (4) GIGI-Pick gives the best selecti

40 The range of allele frequency (44.1% to 55.6%) was established for ge

41 ost frequent mutation was H1069Q (c.3207C>A; allele frequency: 46.9%), followed by P767P-fs (c.2304du

42 The rs11693320-A allele (frequency, ~80%) was associated with lower FVC (

43 Finally, we considered the transition of allele frequencies across geographic space and suggest t

44 The distribution of allele frequencies across populations suggests a northwa

45 (42.6%, 19.7%), respectively, for which the allele frequency (AF) in the Japanese population was 2.2

46 NPD prevalence: 77%), the cumulative PTV/CNV allele frequency (AF) was 7.7% vs. 2.6% in control subje

47 Ultrarare variants (allele frequency [AF] < 0.0001) of 35 genes responsible

48 en in Singaporean HCM (TNNI3:p.R79C, disease allele frequency [AF]=0.018; TNNT2:p.R286H, disease AF=0

49 heterozygote frequencies among populations (allele frequencies: African = 0.0016; East Asian = 0.004

50 can be cast as the difference between marker allele frequencies (AFs) estimated in each of the group

51 al cell-free DNA, as measured by TP53 mutant allele frequency, also affected assay sensitivity.

52 ection is surprisingly effective in altering allele frequencies among many different SNPs that share

53 arboring variants with highly differentiated allele frequencies among the ancestral populations.

54 quantitative trait loci (QTL) and differ in allele frequency among individuals that end diapause ear

55 esentation of haplotype frequencies based on allele frequencies and between-allele co-variances.

56 nced by hundreds of loci spanning a range of allele frequencies and effect sizes.

57 opulation stratification depends not only on allele frequencies and environmental structure but also

58 e marks in geographic arrangements of common allele frequencies and gene-environment correlations.

59 vity and specificity measurements as well as allele frequencies and identified HLA alleles that are c

60 genotyping assay, which we used to determine allele frequencies and identify FcgammaR haplotypes in m

61 leotide polymorphisms (SNPs) with high minor allele frequencies and in SNPs located in the predicted

62 ow researchers to easily compute and compare allele frequencies and LD statistics of dbSNP catalogued

63 We show that differences in allele frequencies and linkage disequilibrium between Eg

64 Minor allele frequencies and population-attributable fraction

65 However, higher risk allele frequencies and population-attributable risk perc

66 mergence tolerance probably due to low minor allele frequencies and presence of exceptions to the kno

67 ion with low nucleotide diversity, divergent allele frequencies and the most private alleles, and obs

68 To increase their allele frequency and assess their phenotypic impact in a

69 ly accurate and strongly agree with expected allele frequency and crossover number.

70 ic filtering and prioritisation according to allele frequency and effect on protein and inheritance p

71 etic architecture of complex traits, such as allele frequency and effect size.

72 (serial monitoring of both KIT D816V variant allele frequency and NGS panels) to lend more diagnostic

73 ndamental statistical trade-off between risk allele frequency and odds ratio.

74 tumor, and mutant peptides with high variant allele frequency and predicted high HLA-binding affinity

75 a heritability model or partitioning SNPs by allele frequency and/or LD.

76 xtent to which they can annotate gene-names, allele frequencies, and variants having high impact on g

77 in the other GWASs due to differences in LD, allele frequencies, and/or sample size.

78 risons of sequence diversity, recombination, allele frequency, and selective pressures.

79 rved nucleotides, tended to have low derived allele frequency, and were depleted from promoters of es

80 wise fashion: mutant genes with high variant allele frequencies appear early in leukaemogenesis, and

81 mber of single cells and in cases where bulk allele frequencies are affected by copy number changes.

82 urate predictions than existing methods when allele frequencies are low, which is of clear advantage

83 SV minor allele frequencies are rarer than amino acid polymorphis

84 emogenesis, and mutations with lower variant allele frequencies are thought to be acquired later(1-3)

85 allowed us to detect mutations with variant allele frequencies as low as 0.001.

86 t of genotyped dogs was used to estimate the allele frequency as between 0.07-0.1 in the UK LA popula

87 or complex traits because of large shifts in allele frequencies at hundreds of loci under selection.

88 variation in the population leads changes in allele frequencies at one time point to be predictive of

89 on-DS ALL case-case analyses, comparing risk allele frequencies at these and other established suscep

90 Mutant allele frequency at baseline was associated with clinica

91 dology for the generation of a genome-wide B-allele frequency (BAF) signal profile from the reads and

92 n FFPE Assay yielded the log ratio (R) and B-allele frequency (BAF).

93 The algorithm accepts genotype calls and 'B allele' frequencies (BAFs) from at least two samples der

94 Combining both local ancestry and allele frequency based analyses, we identify a tripartit

95 We compared our allele-frequency based approach with genotype-based appr

96 While allele frequency-based approaches that do not detect seg

97 Specifically, this tool implements a novel allele frequency-based feature selection algorithm, Lanc

98 researchers in using the LEI tool to develop allele frequency-based informative features to conduct a

99 Allele-frequency-based imputation of tumor (All-FIT) is

100 ty to identify single nucleotide variants at allele frequencies below 0.1%.

101 ependently from separate lineages, with rare allele frequencies below 0.5%.

102 total of 42 unique or rare (population minor allele frequency below 1%) nonsynonymous genetic variant

103 ls, there were no significant differences in allele frequencies between affecteds and controls (C/TTC

104 0%) in simulations with large differences in allele frequencies between cases and controls.

105 A genes were associated with large shifts in allele frequencies between catchments and in individual

106 AIMs exhibit substantial differences in allele frequency between ancestral populations.

107 ference was detected in MUC5B rs35705950 SNP allele frequency between bronchiectasis and healthy indi

108 Changes in SV allele frequency between wild and farmed fish indicate p

109 The geographic mapping of each SNP's allele frequencies by population as well as visualizatio

110 For the allele frequency calculation, the implementation in the

111 data, which includes log R ratio (LRR) and B allele frequency, can be plotted against the reported CN

112 nt dam construction is explained by dramatic allele frequency change at this locus.

113 We estimate that at least 17 to 37% of allele frequency change is driven by selection in these

114 did not find strong evidence of directional allele frequency change or selection for Bd resistance g

115 o estimate what fraction of the variation in allele frequency change through time is driven by linked

116 we partitioned the proportion of variance in allele frequency change through time.

117 We found that observed allele frequency changes are generally well predicted by

118 Observed allele frequency changes are primarily due to variation

119 omes from the genome-wide covariance between allele frequency changes observable from temporal genomi

120 and for short sleepers, the changes exceeded allele frequency changes that would be expected under ra

121 Allele-frequency changes between 1993 and 2006 (70 gener

122 Uncorrected, these allele frequency clines severely confounded inferences o

123 EI to leverage summary-level statistics from allele frequency data, thereby avoiding the many restric

124 A recent tally in the ALFRED allele frequency database finds 164 reference population

125 iant-specific prior information derived from allele frequency databases, consequence prediction algor

126 ified cancer-associated loci that have large allele frequency differences across African populations.

127 n that can lead to the accumulation of large allele frequency differences between populations due to

128 eutral demographic events can create similar allele frequency differences between populations.

129 election were identified using: (i) pairwise allele frequency differences; (ii) genome scan for overl

130 e genes and significant differences in their allele frequency distributions across breeds.

131 uild consensus sequences based on population allele frequency distributions.

132 considering effects of polygenicity, causal allele frequency divergence, and heritability.

133 as mixtures of unobserved populations whose allele frequencies drift over time.

134 rence wheat genotype-phenotype map, explored allele frequency dynamics over time and fingerprinted 44

135 d selection has a large impact on short-term allele frequency dynamics that is readily distinguishabl

136 erozygote phenotype and its consequences for allele frequency dynamics.

137 ants in Europeans, differences in the effect allele frequency, effect size and the linkage disequilib

138 e is calculated incorporating: i) population allele frequency estimates; ii) individual zygosity, det

139 lift, loci can exhibit conspicuous seasonal allele-frequency fluctuations, but often fluctuations ma

140 Correctly specifying population allele frequencies for each individual in early stage of

141 We then used Pool-seq to compare nuclear allele frequencies for high- or low-fitness hybrids.

142 Using damaging allele frequencies for the corresponding human genes and

143 F(2) screen study to estimate the resistance allele frequency for Vip3Aa in H. zea populations in Tex

144 nabled accurate measurement of VAFs (variant-allele frequencies) for mutations, allowing the determin

145 ation and deconvolution of mutation type and allele frequencies from a single tumour sample.

146 proteins, as did all other variants with an allele frequency greater than 0.001.

147 s and insertion-deletion variants with minor allele frequencies >1% and imputation quality scores >0.

148 5 x 10(-8)), where these variants had minor allele frequencies >=1%.

149 t imputation quality of r(2) > 0.7 and minor allele frequency > 0.005.

150 have mainly analyzed common variants (minor allele frequency > 0.05).

151 than seen in the general population, variant allele frequency > 0.3 of a deleterious allele in a know

152 almost 7 million genetic variants with minor allele frequency > 5% and identified one single linkage

153 Associations between polymorphisms (minor allele frequency >/= 15%) in 4 genes and seizure outcome

154 WAS) including low-frequency variants (minor allele frequency >/=0.005) for BUA and VOS using a disco

155 e presence of any CHIP and CHIP with variant allele frequency >0.1.

156 The percentage of SNPs with minor allele frequency >0.10 was 95% and 91% in the euchromati

157 zard ratio associated with CHIP with variant allele frequency >0.1: 1.48 [95% CI, 1.13-1.94]; P=0.005

158 [95% 1.10-1.68]; P=0.004; CHIP with variant allele frequency >0.1: odds ratio, 1.40 [95% CI, 1.10-1.

159 % CI, 1.23-2.44]; P=0.001; CHIP with variant allele frequency >0.1: odds ratio, 1.91 [95% CI, 1.30-2.

160 bolite pairs (p value < 1.2 x 10(-10), minor allele frequency >= 1%, proportion of variance explained

161 ensitive approach, we identified CH (variant allele frequency >=0.5%) in 62% of individuals.

162 Sample size and minor allele frequency had a major influence on SPAEML's abili

163 Remarkably, reported minor allele frequency had a substantial effect on concordance

164 considering linkage disequilibrium and minor allele frequency had the highest accuracies.

165 Allele frequency, haplotype-based, and ancient genome an

166 ecific rare variant, rs72725854 (A>G/T) (~6% allele frequency) has been associated with a ~2-fold inc

167 Parkinson's disease had significantly higher allele frequencies in a combined cohort of Japan and Tai

168 iptions of short-term evolutionary change in allele frequencies in a natural population to date.

169 the genome into three hidden states based on allele frequencies in genomic data: a symmetric state (s

170 We measured SP-resistance allele frequencies in Malawian women participating in a

171 the sexes, whereas tests for the equality of allele frequencies in the sexes assume Hardy-Weinberg eq

172 -Weinberg equilibrium assume the equality of allele frequencies in the sexes, whereas tests for the e

173 15)), seven of which had crucially low minor allele frequency in European population.

174 n pairs, of which 421 SNVs segregate at > 1% allele frequency in human populations.

175 f additional mutations or increasing variant allele frequency in K/NRAS, RUNX1, IDH2, or NPM1 associa

176 ependent reversions indicated that reversion-allele frequency in metastatic sites is an important det

177 on between SSc prevalence and HLA-DPB1*13:01 allele frequency in multiple populations was observed (r

178 rediction method to calculate initial mutant allele frequency in tissue biopsy and blood samples with

179 Existing methods rely on population allele frequency information for accurate estimation of

180 stimator of Independence (LEI) that utilizes allele frequency information to prioritize the most info

181 of approximately 9,000 subclonal mutations (allele frequencies <0.1%); of these, approximately 8,000

182 ts carry a very rare missense variant (minor allele frequency < 0.0001) in BRIP1.

183 g two rare variants (European ancestry minor allele frequency < 0.01, at 3p21.31 and 8p12), were sign

184 ced for the identification of rare variants (allele frequency < 0.05) in 16.9 kB of SERPINA1.Measurem

185 heteroplasmies (Phred score > 10,000, minor allele frequency < 0.5, number of mutant reads > 1).

186 We identified rare (allele frequency < 4x10(-5)) biallelic CPAMD8 variants i

187 riants in total, of which 27 were rare (ExAc allele frequency <0.002).

188 One SNV with a minor allele frequency <0.01, (rs3025380 at DBH) was genome-wi

189 ssociated genomic regions and 87 rare (minor allele frequency <= 0.01) variant BP associations (P < 5

190 nts, is capable of SNV detection at very low allele frequency (<1%), and detects SNVs with high sensi

191 hnic groups, BAG3 rs17617337 was rare (minor allele frequencies<0.05) in Asian and African ancestry p

192 cy functional protein-coding variants (minor allele frequency, <=5%) measured by an exome array were

193 te-risk genes, particularly those with minor allele frequencies (MAF) of < 30%, have not been identif

194 e-nucleotide polymorphisms (SNPs) with minor allele frequency (MAF) > 0.1% and imputation quality sco

195 oni correction, rs505922 (beta: -6.5% [minor allele frequency (MAF) 0.32, P = 3.3 x 10(-8)]) located

196 significant association (rs146350366, minor allele frequency (MAF) 1.2%, P = 3.2 x 10(-8), odds rati

197 the tissue adjacent to the cartilage [mutant allele frequency (MAF) 6-8%], and were enriched in endot

198 y variant (rs1039215 in HBG2 and HBE1, minor allele frequency (MAF) = 0.03).

199 , rs9998811, rs7696092 and rs13145758 (minor allele frequency (MAF) = 25-44%; P < 3 x 10(-14)) of sol

200 ce attack and show the privacy loss in minor allele frequency (MAF) and chi-square queries.

201 effect size increases with decreasing minor allele frequency (MAF) and linkage disequilibrium (LD) c

202 h-quality imputation from markers with minor allele frequency (MAF) as low as 0.0001.

203 e, we develop a method to estimate the minor allele frequency (MAF) dependence of SNP effect sizes.

204 permutation threshold is influenced by minor allele frequency (MAF) of the SNPs, and by the number of

205 ously unreported variants had distinct minor allele frequency (MAF) spectra between people of Japanes

206 describes how heritability varies with minor allele frequency (MAF), linkage disequilibrium (LD) and

207 ily (ERF) study, we identified a rare (minor allele frequency (MAF)=1%) missense c.1114C>T mutation (

208 sociation with diabetes risk (combined minor allele frequency [MAF] 0.22%; odds ratio [OR] 2.02; 95%

209 studies, the 3q13.33 locus (rs9831894; minor allele frequency [MAF] = 0.40) was associated with DLBCL

210 mutation in MEPE, p.(Lys70IlefsTer26, minor allele frequency [MAF] = 0.8%), was associated with decr

211 Ultra-rare (minor allele frequency [MAF], <=0.0001) CFH variants were iden

212 We identified 15 common (minor allele frequency, MAF >=5%) and nine low-frequency or ra

213 On the other hand, incorrectly specified allele frequencies may result in substantial bias in est

214 ypes using WES variants strictly filtered on allele frequency, mutation consequence, and evidence of

215 Each copy of the minor allele (frequency of 4.7%) reduces height by 2.2 cm (4.4

216 For rare variation, with minor allele frequencies of 0.5% or less, very large samples o

217 Allele frequencies of all TRDN null variants identified

218 SVclone accurately determines the variant allele frequencies of both SV breakends, then simultaneo

219 Cellular allele frequencies of examined L1 insertions indicated h

220 vors of WNS, and found significant shifts in allele frequencies of genes associated with regulating a

221 We measured the corresponding changes in the allele frequencies of genomic variants responding to art

222 hole-genome sequencing data by utilizing the allele frequencies of heterozygous single nucleotide pol

223 le maintaining the ability to correctly call allele frequencies of known single nucleotide variants.

224 Cellular or population allele frequencies of L1s were assessed by droplet digit

225 el associations of rare variants (with minor allele frequencies of less than 0.5%) in 4 genes at exom

226 Those with minor allele frequencies of less than 44.1% were assumed to be

227 re-specify the patterns of clusters by minor allele frequencies of SNPs between cases and controls, a

228 lk analysis can only provide average variant allele frequencies of the targeted genes across all samp

229 Allele frequencies of these acquired variants were overa

230 The allele frequencies of these variants reversed course in

231 Although the minor allele frequencies of TMEM40 rs11719526 were generally c

232 Minor allele frequencies of two fetal CD46 SNPs were significa

233 estimate specimen tumor purity based on the allele frequencies of variants detected in high-depth, t

234 enomics-classification, (2) appeared with an allele frequency of <1:10.000, and (3) segregated with D

235 tremely rare in a large population database, allele frequency of 0.000024.

236 The variant (p.Lys679Met) has an allele frequency of 0.0002 and is predicted to be a dama

237 hisms (SNPs) were discovered using a minimum allele frequency of 1% across the entire genome through

238 helial lipase (LIPG) gene, occurring with an allele frequency of 1% in the general population, which

239 ), and TT in 85 patients (10%), with a minor allele frequency of 30%.

240 isease model with 100% penetrance and a risk allele frequency of 5%.

241 al agenesis patients revealed a higher minor allele frequency of a SNP 3' of the GATA6 coding sequenc

242 The allele frequency of APOE4 was not significantly differen

243 eloid cancer-associated genes with a variant allele frequency of at least 2%.

244 BigTop uses the z-axis to display minor allele frequency of each SNP, allowing for the identific

245 show an inverse correlation of the worldwide allele frequency of functional KIR2DS4 with that of HLA-

246 3 parts of the study that establish (1) the allele frequency of germline variants (n = 100), (2) the

247 tumours revealed an extreme shift in variant allele frequency of somatic variants, suggesting that ce

248 a statistical test to determine whether the allele frequency of the putative variant is significantl

249 plasin A (Eda) genotypes to infer changes in allele frequencies over time.

250 he differences in linkage disequilibrium and allele frequency patterns across ethnic groups may incre

251 equencing read depth information and variant allele frequency patterns, to infer the true copy number

252 reveals the relative abundance of different allele frequency patterns.

253 es of adiposity in Pima Indians, where the G allele (frequency: Pima Indians = 0.60, Europeans <0.01)

254 We enumerated 49,138 rare (<1% minor allele frequency) pLoF mutations.

255 es the calculation of subpopulation specific allele frequency possible, which may shed light on selec

256 framework by leveraging individual-specific allele frequencies projected from reference genotypes on

257 elomeric SNPs indicated general agreement of allele frequencies (R = 0.95) and of the substitution ef

258 Differences in allele frequencies remained constant through the studied

259 uals of African ancestry (~10% and ~1% minor allele frequency, respectively, and rare or monomorphic

260 ancestry informative variants with different allele frequency/selection pressure among (or between) a

261 t immigrants is substantial, with some large allele frequency shifts that otherwise may have been att

262 Comparisons of replicate lines show parallel allele frequency shifts that recapitulate responses to s

263 , show how this contributes to signatures of allele frequency shifts, and highlight how the rapid acc

264 The minor allele frequency showed the same effect size (OR > 1) am

265 oving its reliability in calling low variant allele frequencies somatic SNVs in low ctDNA levels plas

266 ustrating that genetic variation from a wide allele frequency spectrum contributes to cranial growth.

267 orary Ethiopian genomes, affects the overall allele frequency spectrum to an extent that makes it har

268 associations (P < 7.45 x 10(-11)) across the allele frequency spectrum, all of which replicate in an

269 abetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis

270 me variation, genome-wide, across the entire allele frequency spectrum.

271 oach to correct this bias using LD and minor allele frequency stratified inference (LDMS).

272 s study, the consistency of increase in 132L allele frequency suggests pathogen-mediated selection ha

273 Analysis of variant allele frequencies supported a model of tumor growth inv

274 ences in linkage disequilibrium or in causal alleles frequencies), the prediction accuracy of polygen

275 on the sample size, the (unknown) population allele frequencies, the actual relatedness and the estim

276 Based on African population reference allele frequencies, the Apoliprotein E genotypes would b

277 onsequences that drive changes in population allele frequency, thereby illuminating the process of ev

278 d statistical performance of different minor allele frequency thresholds and a range of genetic effec

279 rift, natural selection, and gene flow shape allele frequencies through time.

280 rise SNVs at complex variant loci and at low allele frequency thus increasing the repertoire of detec

281 features like variant consequence and minor allele frequency to annotate the plot and addresses thes

282 n gene (BCR-ABL1) assay down to 0.01% mutant allele frequency to highlight the platform's utility for

283 whether these putatively adaptive shifts in allele frequencies translate into sufficient increases i

284 vast majority of human mutations have minor allele frequencies under 1%, with the plurality observed

285 VAF phasing uses changes in variant allele frequency (VAF) between tumor and normal samples

286 analyzed for acquired mutations at a variant allele frequency (VAF) of 1% or higher in 27 driver gene

287 When a 2.5% variant allele frequency (VAF) threshold was applied, actionable

288 X1, and/or DNMT3A (A/R/D) pathogenic variant allele frequencies (VAFs) >= 30%, exhibited significantl

289 ge constraints imposed by the use of variant allele frequencies (VAFs, derived from bulk sequence dat

290 CD4 allele frequencies varied among wild chimpanzees, with h

291 ssociated nominally with BCG osteitis; minor allele frequency was 0.215 in 130 BCG osteitis cases and

292 in circulating tumor DNA BRAF(V600E) variant allele frequency was seen in 87% versus 0% of patients (

293 marize the asymmetric pattern of Neanderthal allele frequencies, we compiled the joint fragment frequ

294 g Dirichlet and Beta priors for genotype and allele frequencies, we derive marginal likelihoods for a

295 ed with cancer predisposition were analyzed; allele frequencies were compared with publicly available

296 cancer cell lines with increased KRAS mutant allele frequency were more sensitive to MAP kinase inhib

297 Specifically, viral allele frequencies, which form the basis of many calcula

298 reeds, Greyhounds had the highest CYP2B11-H3 allele frequency, while CYP2B11-H2 was widely distribute

299 e ones (1,380 fish) to associate genome-wide allele frequencies with continuous distributions of envi

300 and led to divergence between treatments in allele frequencies, with regions showing strong divergen