ライフサイエンスコーパス: allene

1 e that performs an alkyne walk to afford the allene.

2 ctive addition can be achieved from the same allene.

3 -cyclohexadiene, a rarely exploited strained allene.

4 l level of chirality transfer from a pendant allene.

5 e reaction proceeds via acetoxylation of the allene.

6 xemplified by the reaction with an activated allene.

7 timately permit access to an enantioenriched allene.

8 aneous to stereoinduction on an axial chiral allene.

9 hydride donor for the synthesis of terminal allenes.

10 ides, showcasing the first halo-arylation of allenes.

11 r CdI2 for the synthesis of 1,3-disubstitued allenes.

12 ynthesis of di-, tri-, and tetra-substituted allenes.

13 of propargylic sulfides to give substituted allenes.

14 ifferent from previously reported 1,3-DCs of allenes.

15 s to pi-allyls in the absence of intervening allenes.

16 ies for stereocontrol in reactions of cyclic allenes.

17 inal alkynes provides di- and trisubstituted allenes.

18 ieved by intramolecular hydroalkoxylation of allenes.

19 during the functionalization of alkynes and allenes.

20 roup for a range of substituted phenones and allenes.

21 hat are difficult to access via nonsilylated allenes.

22 the bonding situation and vast reactivity of allenes.

23 al methods to the wide and rich chemistry of allenes.

24 ghtened reactivity with thioester-containing allenes.

25 nspired in the chemistry developed in simple allenes.

26 acids, their derivatives, or TBS-substituted allenes.

27 on of the iron-catalyzed C-H alkylation with allenes.

28 es add to alkynyl imines to form 1,3-alkenyl allenes.

29 Phthalimido-allene 1 and primary alcohols 2a-2z, 2a'-2c' engage in h

30 Treatment of readily available allene 1 with Cy2BH followed by addition of an aldehyde

31 do-1,3-oxazoles to produce 1,1-disubstituted allenes (11).

32 uctive coupling of diverse 1,1-disubstituted allenes 1a-1u with fluoral hydrate 2a to form CF(3)-subs

33 ntramolecular cyclization of the heteroenyne-allene, 2-((phenylimino)methyleneamino)-benzonitrile (1)

34 dem gold-catalyzed furan formation and furan-allene [4+3] cycloaddition to build the 5,7-fused ring s

35 More sterically encumbered allenes afford higher cycloadduct yields, and such effec

36 ic mechanism involving ruthenium(0)-mediated allene-aldehyde oxidative coupling to form a transient o

37 putations suggests that the initially formed allene-aldehyde product assists in the transformation of

38 he conversion of propargyl vinyl ethers into allene aldehydes, proceeds under homogeneous conditions

39 The latter allenes also gave 4-methylenepyrrolidines on reacting wi

40 Although simple allene and acetylene have similar reaction barriers, int

41 r merging an N-H ketimine, a monosubstituted allene and B2(pin)2, affording products in up to 95% yie

42 based organic chiral magnetic molecules with allene and cumulene couplers have been theoretically des

43 ctivated by gold(i), in an order of alkynes, allenes and alkenes.

44 or the selective synthesis of monodeuterated allenes and chiral 2,5-dihydropyrroles are described.

45 stereoselectivity in the (3+2) annulation of allenes and enones catalyzed by an amino acid derived ph

46 atalyze the CC coupling of 1,1-disubstituted allenes and fluorinated alcohols to form homoallylic alc

47 ivatives, such as dienynes, enediynes, enyne-allenes and hetero-analogues.

48 of the fundamentals of radical additions to allenes and highlight the emergence of theoretical and e

49 ith various 1,1-di- and 1,1,3-trisubstituted allenes and N-hydroxyaniline derivatives.

50 l [4 + 2]-cycloadditions between substituted allenes and N-hydroxyanilines are described.

51 Cycloaddition reactions between allenes and partners containing pai-bonds, which are lik

52 oquinolines are synthesized in one step from allenes and phenylethylamines or benzylamines, respectiv

53 the intervening years, both the chemistry of allenes and the reactivity of single-electron species ha

54 enhanced scope (the use of gamma-substituted allenes), and good ee.

55 ing radical, the substitution pattern of the allene, and the length of the linker between the radical

56 ed reactions of specially activated alkynes, allenes, and alkenes.

57 colaldehyde imine to afford allylic hydroxyl allenes, and allyl boronates add to alkynyl imines to fo

58 re, couples readily available simple imines, allenes, and diboranes, and yields high-value homoallyli

59 nt- and oxidant-dependent transformations of allenes are described.

60 Allenes are important 2pi building blocks in organic syn

61 Aliphatic allenes are incompatible with the reaction conditions.

62 Cascade reactions involving nitrones and allenes are known to facilitate the rapid synthesis of s

63 droazidation and hydroamination reactions of allenes are presented herein.

64 Allenes are useful functional groups in synthesis as a r

65 Unsymmetrically substituted allenes are well tolerated with nickel catalysis and aff

66 ation of two new and rare examples of a bent allene as well as the isolation of the first carbene-car

67 C-C activation of cyclobutanones and employs allenes as a one-carbon unit.

68 metalation process enables the use of simple allenes as allylmetal nucleophile surrogates in imine al

69 reactivity patterns for radical additions to allenes as compared with other unsaturated compounds.

70 only confronted the great challenge in using allenes as dipolarophiles of 1,3-DCs, but also provided

71 but also provided a unique strategy of using allenes as equivalents of alkynes to construct spiro[ind

72 This reaction pathway furnishes alpha-boryl allenes as the reaction product.

73 search contents of 1,3-DCs, the chemistry of allenes as well as the synthetic methods of spirooxindol

74 catalytic [4+2] and [4+3] cycloadditions of allenes, as efficient and practical methodologies for as

75 ntramolecular N2-arylation of pyrazoles with allenes at the C-beta position of triple bond.

76 as an indispensable element for the initial allene attack involving allenic C(sp(3))-H bond cleavage

77 A tandem allene aziridination/[4+3]/reduction sequence converts s

78 In contrast, with (1H-tetrazol-5-yl)-allenes bearing bulkier substituents at C-3, such as i-p

79 rearrangement of an enantiopure chiral enyne-allene (bearing one stereogenic center) selected as a mo

80 with beta addition of the phosphepine to the allene being the turnover-limiting step of the catalytic

81 eveal reactivity that is available to cyclic allenes beyond the traditional cycloadditions and nucleo

82 copper-catalyzed three-component coupling of allenes, bis(pinacolato)diboron, and imines allows regio

83 When the vinyl substituents are placed on allene, both the hydride and the proton affinities incre

84 allene formation (af) and rotamerization of allene-bound gold complex (ra) are found to be quite fac

85 dependencies reveal that the dynamics of the allene buildup are controlled by the structural changes,

86 gement followed by trapping of the resulting allenes by an adjacent pyrrole ring.

87 ation of propargylic alcohols into transient allenes by means of a strategic [2,3]-sigmatropic rearra

88 d for the synthesis of imidazole-substituted allenes by the reaction of 1,1,3-triphenylprop-2-yn-1-ol

89 ed (4+2) coupling between cyclobutanones and allenes, by C-C cleavage, is reported.

90 Allene (C(3)H(4)) gas is produced and separated on milli

91 six-membered transition state of the Zn-ene-allene carbocyclization found by DFT calculations.

92 ective 5-exo aminocyclization to the central allene carbon followed by aromatization.

93 between the radical center and the proximal allene carbon in the substrate.

94 ddition of amino functionality to the distal allene carbon to yield enantiopure 2,5-dihydro-1H-pyrrol

95 p toward either the internal or the terminal allene carbon, respectively, being favored.

96 Allene carboxylates, scarcely used as Michael acceptors,

97 the carbodicarbene-type ligand "cyclic bent allene" (CBA) have been synthesized from the common prec

98 The allene character of the spacer implies an orthogonal ori

99 of chemical bonding renders 1,3-substituted allenes chiral, making them attractive targets for asymm

100 Allenes constitute an important subclass among these.

101 k rearrangement and Zn-ene-allene (or Zn-yne-allene) cyclization reaction.

102 The fascinating intramolecular arene/allene cycloaddition discovered by Himbert affords dearo

103 ted to steric interactions and the degree of allene deformation as significant factors in determining

104 udy of complex reaction mechanisms involving allene derivatives in organic and organometallic chemist

105 from cinchona alkaloids, provided nonracemic allene derivatives.

106 ing field and survey the borylative union of allenes, dienes, styrenes and other olefins, with imines

107 chanism of the Diels-Alder reactions with an allene dienophile.

108 tuted allenes is associated with a competing allene dimerization that irreversibly sequesters rhodium

109 uents significantly increases the barrier of allene dimerization while the barrier of the (5 + 2) cyc

110 The connected continuous process of allene dissolution, lithiation, Li-Zn transmetallation,

111 red that methyl substituents on the terminal allene double bond counterintuitively change the reactiv

112 This leads to the greater reactivity of the allene double bond relative to the alkynyl group in alle

113 llene-ynes occur exclusively at the terminal allene double bond.

114 erive from catalytic nitrene addition to the allene double bonds.

115 type hydride transfer to an in situ prepared allene enables the synthesis of ortho-fused 4-substitute

116 transformations: kinetic differentiation of allene enantiomers and desymmetrization of intermediate

117 nitial kinetic differentiation of the cyclic allene enantiomers through stereoselective olefin insert

118 suggests that this reaction proceeds via an allene-enyne intermediate generated by an Alder-ene reac

119 the substituent of the alkyne moiety on the allene-enyne intermediate, the subsequent transformation

120 ts from the involvement of two regioisomeric allene-enyne intermediates.

121 virtue of an in situ base-promoted alkyne to allene equilibration which takes place prior to the sily

122 However, a related species, strained cyclic allenes, especially heterocyclic derivatives, have only

123 scribes their use in various versions of the allene ether Nazarov cyclization.

124 izations of 4-allen-1-ols into one prochiral allene face.

125 nt and most importantly maintained excellent allene facial selectivities regardless of the substrate

126 In contrast, silylated allenes favor the formation of propargylic cation interm

127 Ir-PP-I, that is catalytically competent for allene-fluoral reductive coupling and previously reporte

128 rylation of the substituted pi-system of the allene followed by hydroboration of the remaining pi-com

129 ell as activation of an unsaturated aldehyde-allene for a [2 + 2] cycloaddition reaction.

130 and indicate the participation of mainly the allene form in the reaction.

131 atory steps of the catalytic process such as allene formation (af) and rotamerization of allene-bound

132 he regioselectivity results from a selective allene formation that is governed by allylic strain.

133 preparation of a trisubstituted iodoalkene, allene formation using the Myers-Movassaghi protocol, st

134 e means to generate the parent 3,4-oxacyclic allene from a readily accessible silyl triflate precurso

135 o directly synthesize enantioenriched chiral allenes from achiral precursors.

136 nantioselective methods to synthesize chiral allenes from chiral starting materials, fewer methods ex

137 ve synthesis of axially chiral disubstituted allenes from prochiral starting materials remains a long

138 A general method to access CF(3)-substituted allenes from propargylic alcohols under Lewis acid catal

139 aldehydes, nucleophiles, and monosubstituted allenes furnishes functionalized non-C2-symmetric naphth

140 process for asymmetric propargylation using allene gas as a reagent is reported.

141 Herein, we report that the combination of allene gas with inexpensive and environmentally benign h

142 alpha-(1'-fluoro)vinyl trigger, a potential allene-generating functionality originally proposed by A

143 al (CH) with methylacetylene (CH(3) CCH) and allene (H(2) CCCH(2) ) under single-collision conditions

144 in which substituents on the termini of the allenes had rotated away from the vinyl moieties, and th

145 -unsaturated nitrones and electron-deficient allenes has been discovered that allows single-step acce

146 is tutorial review highlights the value that allenes have as reagents in [2+2+2] cycloaddition and th

147 vergent hydrosilylation of 1,3-disubstituted allenes have been developed.

148 DCs) of isatin-derived azomethine ylide with allenes have been established, which efficiently assembl

149 (1H-Tetrazol-5-yl)-allenes have been prepared for the first time, and their

150 s, such as arynes, cyclic alkynes and cyclic allenes, have intrigued chemists for more than a century

151 mple of intermolecular C-O bond formation by allene hydrofunctionalization.

152 borate a catalytic mechanism involving rapid allene hydrometalation followed by turnover-limiting car

153 ng alcohol dehydrogenation followed by rapid allene hydrometalation.

154 sent a critical tracer of microwave-inactive allene in cold molecular clouds, thus defining constrain

155 tals that serve as chiral auxiliaries on the allene in highly enantioselective Nazarov cyclizations i

156 reaction proceeds rapidly, generating chiral allenes in 10-20 minutes with high enantioselectivity (8

157 ed to the corresponding trisubstitued chiral allenes in 71-89% yields with up to 99% ee upon reaction

158 this enigmatic reactivity and selectivity of allenes in [Rh(CO)2Cl]2-catalyzed intermolecular (5 + 2)

159 ounterintuitively change the reactivities of allenes in [Rh(CO)2Cl]2-catalyzed intermolecular (5 + 2)

160 y chiral biphenols to access enantioenriched allenes in a traceless Petasis reaction.

161 le the further study of strained alkynes and allenes in chemical synthesis.

162 onent transformation is also compatible with allenes in place of alkynes to furnish tetrasubstituted

163 eported for the syn-insertion of alkynes and allenes in the Au-Si bonds of complexes (R3P)Au-SiR'Ph2

164 ldehydes were reacted with 1,3-disubstituted allenes in the presence of PPh2Et, naphthalene derivativ

165 preparation of eight-membered rings from bis(allenes) in the absence of metals have been achieved by

166 addition of a trifluoromethyl radical to an allene; in the intervening years, both the chemistry of

167 onal group adds to the central carbon of the allene, initiating a sequence of bond-forming reactions,

168 terest in the study of the reactivity of bis(allenes) inspired in the chemistry developed in simple a

169 Instead, cyclization of the allene intermediate either does not take place or is ver

170 Mechanistic studies suggest formation of an allene intermediate, which undergoes hydroamination to g

171 and triple bond formation through a putative allene intermediate.

172 we report the interception of racemic cyclic allene intermediates in a catalytic asymmetric reaction

173 In general, reactions of nonsilylated allenes involve an allylic cation intermediate by formin

174 In this allene-involved 1,3-DC, an unexpected spirooxindole fram

175 idative C-C bond forming cascade reaction of allenes involving a coupling between an enallene and an

176 and indicate that the low conductance of the allene is a general feature of [n]cumulenes where n is e

177 selectivity observed experimentally with the allene is shown to result from the insertion of the term

178 The asymmetric isomerization of alkyne to allene is the most efficient and the completely atom-eco

179 tion-metal catalysed nucleophile addition to allenes is a very powerful tool for the synthesis of fun

180 ent hydroformylation of 1,1,3-trisubstituted allenes is accomplished with low loadings of a Rh cataly

181 Hydrofunctionalization of allenes is also a totally atom economical strategy, avoi

182 The chemistry of allenes is an appealing topic which fascinates chemists

183 t low reactivity of terminally unsubstituted allenes is associated with a competing allene dimerizati

184 he metal-catalyzed hydrofunctionalization of allenes is nowadays one of the most studied transformati

185 nickel-catalyzed [2+2] cycloaddition of ene-allenes is reported.

186 ative addition of beta-ketoacids to terminal allenes is reported.

187 ntermediates from nonsilylated and silylated allenes is strongly supported by DFT calculations.

188 of examples of cyclization reactions of bis(allenes) is presented as well as the future perspectives

189 ion, occurring on the terminal carbon of the allenes, is totally regio- and stereoselective.

190 Two different coordination modes of the allene isomer of triphenylphosphoniumpropargylide to gol

191 The alkyne-allene isomerization involves not only a torsional motio

192 r media, it is rapidly followed by an alkyne-allene isomerization of the excited branch.

193 eal the occurrence of an efficient alkyne to allene isomerization of the spacer with a time constant

194 +2] annulation process was devised employing allene ketones as C2 synthons and beta,gamma-unsaturated

195 Pr), which features a mu-oxo ligand along an allene-like molecular core.

196 he Pd-catalysed formation of a C-O bond from allenes mainly occurs via the inter- or intramolecular r

197 allenyl-boron compound or a monosubstituted allene may be used.

198 rst catalytic asymmetric cyclopropanation of allene, mediated by the dirhodium catalyst Rh2 (S-TBPTTL

199 inities (HAs) of organic bases possessing an allene moiety and substituted with methyl, dimethylamino

200 roarylation across the central carbon of the allene moiety has not been detected.

201 e addition of a 1-trimethylsilyl-substituted allene moiety to phosphinoylimines is presented.

202 ated to the iridium metal center via the key allene moiety.

203 The conductance of the allene (n=2) is much lower, because of its twisted geome

204 n and trapping of the enantioenriched cyclic allene occurs with complete transfer of stereochemical i

205 The product allene of the aryldiazoacetates undergoes rearrangement

206 of nonconjugated 2-azetidinone-tethered bis(allenes) on application of microwave irradiation.

207 pact of different substrates (alkynes versus allenes) on the reaction mechanism has been discussed in

208 erse transformations of alkenes, alkynes and allenes, opening new opportunities for chemical synthesi

209 used as a hydrocarbonation partner (alkyne, allene or alkene).

210 whether cyclization reactions of conjugated allenes or ketenes follow a pericyclic or a pseudopericy

211 an allenyl-Zn-Brook rearrangement and Zn-ene-allene (or Zn-yne-allene) cyclization reaction.

212 n protein transforms arachidonic acid to the allene oxide 8R,9-epoxy-5,9,11,14-eicosatetraenoic acid

213 is sustained by further increases in LOX and allene oxide cyclase mRNA and protein levels.

214 he coral Capnella imbricata, form a being an allene oxide synthase and form b giving uncharacterized

215 indicating differing gene regulation of the allene oxide synthase and the newly identified catalase-

216 ombined, promote stomatal closure of ABA and allene oxide synthase biosynthetic mutants, albeit most

217 ly alter oxylipin profiles, particularly the allene oxide synthase branch of the oxylipin pathway, re

218 The coronative insensitive1 dgd1 and allene oxide synthase dgd1 double mutants no longer exhi

219 A mutant deficient in JA biosynthesis (allene oxide synthase) displayed enhanced sensitivity to

220 The transformation of vinyl allene oxides into cyclopentenones is key to the biosynt

221 esis and reactivity of methylene aziridines, allene oxides/spirodiepoxides, methylene silacyclopropan

222 tion of a Rh-allyl intermediate.Reduction of allenes poses several challenges in terms of chemo-, reg

223 cient regioselective hydrostannylation of an allene precursor, and the construction of the triene fra

224 A cascade cyanation/diborylation of terminal allenes proceeds efficiently with copper catalysis using

225 f paraformaldehyde with dienes, alkynes, and allenes provide access to products of hydrohydroxymethyl

226 be extended to the reaction of aldehydes and allenes, providing silyl-protected allylic alcohol deriv

227 yl-3-phenylaziridine, whereas with the other allenes, pyrroles were obtained as major products togeth

228 iridium catalyst modified by PhanePhos, CF3-allenes react with methanol to form branched products of

229 g [Tp*(,Br)Ag](2) as the catalyst precursor, allenes react with PhI=NTs in the first example of effic

230 All the studied (1H-tetrazol-5-yl)-allenes reacted with N-benzyl-cis-3-phenylaziridine-2-ca

231 reaction time and temperature, the obtained allenes rearrange to 1,3-biaryl-1-trifluoromethyl-1H-ind

232 out to be selective with respect to propyne-allene rearrangements.

233 The nature of the substituent at the allene seems crucial for the reaction outcome since aryl

234 yl triflate precursors to cyclic alkynes and allenes serve as valuable synthetic building blocks.

235 With terminally substituted allenes, steric repulsion between the terminal substitue

236 tivity of allenes, the subtle differences in allene structures are manifested in the formation of div

237 of the three potential reactive sites in an allene substrate are described.

238 nsformation encompasses a broad range of ene-allene substrates, thus providing efficient access to fu

239 f an enyne-allene with two aryl rings at the allene terminus experimentally leads to three formal Die

240 e-allenes with an aryl group as probe at the allene terminus follow a dynamic non-IRC Diels-Alder cyc

241 the desymmetrization of alkene-, alkyne- and allene-tethered cyclohexadienones using transition metal

242 the smallest studied superbase, whereas the allene tetrasubstituted with four vinyl groups gives the

243 lyzed [4 + 1] annulation of an amine with an allene that furnished an achiral dihydropyrrole in 22% y

244 m with 1-phenyl-1,2-dien-1-yl diazoacetate - allenes that are rapidly formed at room temperature thro

245 reaction of acetone addition to propyne and allene, the addition of acetone and acetophenone to meth

246 are example of a Type I DyKAT reaction of an allene, the first example of DyKAT in a cyclocarbonylati

247 For the synthesis of 1,3-disubstituted allenes, the propyne derivatives containing either a all

248 ence of the substituent on the reactivity of allenes, the subtle differences in allene structures are

249 e copper-boron addition to a monosubstituted allene; the resulting boron-substituted organocopper int

250 he formation of a palladacycle into which an allene then undergoes insertion.

251 affording the enantioselective reduction of allenes, thereby yielding access to motifs commonly used

252 t over the past 20 years in the chemistry of allenes, this "forgotten" family of unsaturated molecule

253 vely transferring the axial chirality of the allene to central chirality in the products.

254 d(I)-catalyzed cyclization of a beta-hydroxy allene to construct the dihydropyran ring.

255 catalysts enables the conversion of racemic allene to enantiopure cyclopentenone product in a dynami

256 uence involving addition of a gold-activated allene to the furan moiety of the starting furoindole fo

257 ly diverted to the distal double bond of the allene to yield endocyclic bicyclic methyleneaziridines

258 sequence comprises initial isomerizations of allenes to butadienes under N2 and subsequent oxidations

259 alytic system that reduces a variety of aryl allenes to chiral benzylic compounds with excellent sele

260 oarenes, isomerizations of alkyl-substituted allenes to dienes, and final nitroso/butadiene [4 + 2] c

261 n the equilibrium structure and chirality of allenes to recent advances in the study of complex react

262 This article reviews methods for converting allenes to strained, three-membered methylene heterocycl

263 d-catalyzed oxidative (4+2) annulations with allenes, to produce highly valuable tetrahydroisoquinoli

264 were subsequently transformed to the desired allenes under CdI2 or ZnI2 catalysis.

265 ces strain-promoted cycloadditions of cyclic allenes under mild conditions to DNA-encoded library syn

266 c method for enantioselective addition of an allene unit to aldimines is disclosed.

267 catalytic method for the hydroalkylation of allenes using alkyl triflates as electrophiles and silan

268 njugated enynes to furnish 1,3-disubstituted allenes using water as the proton source.

269 ates from N-heterocyclic phosphine (NHP) and allenes via phospha-Michael/intramolecular nucleophilic

270 resence of triethylamine afforded the target allenes via Wittig reaction of the in situ generated pho

271 roducts are obtained in up to 91% yield, 98% allene (vs propargyl) selectivity, and 98:2 enantiomeric

272 main diastereoisomer of 3-methyl-1-xyloside-allene was determined for the first time by single-cryst

273 The iron-catalyzed hydroarylation of allenes was accomplished by weak phenone assistance.

274 The addition of carboxylic acids to allenes was performed with copper catalysis.

275 Tetrasubstituted allenes were achieved with up to 42:1 diastereomeric rat

276 he respective terminal and 1,3-disubstituted allenes were studied.

277 hanisms of gold-catalysed transformations of allenes which are based on computational studies, labell

278 nt with fleeting cycloocta-1,2-diene (cyclic allene), which was fully characterized as two conformers

279 (4+1) cyclization between cyclobutanones and allenes, which provides a distinct [4.2.1]-bicyclic skel

280 alytic asymmetric ketone-involved 1,3-DCs of allenes, which will also greatly enrich the research con

281 to investigate the (4 + 2) cycloadditions of allene with butadiene and with benzene.

282 strially relevant C3 hydrocarbon mixtures of allene with methylacetylene and propylene to be applied

283 (2)-C(6) (Schmittel) cyclization of an enyne-allene with two aryl rings at the allene terminus experi

284 A disubstituted allene with two dimethylamino groups is the smallest stu

285 alyzed regioselective alkoxycarbonylation of allenes with aliphatic alcohols allows to produce synthe

286 catalyzed intermolecular [3+2] annulation of allenes with alkenes; however, there have not been corre

287 ional (DFT) investigations reveal that enyne-allenes with an aryl group as probe at the allene termin

288 A library of tetrasubstituted allenes with broad functionalities have been prepared wi

289 ates reductive coupling of 1,1-disubstituted allenes with formaldimines with complete branch-regiosel

290 drogenative C-C couplings of dienes or CF(3)-allenes with methanol.

291 ive intermolecular hydrofunctionalization of allenes with N-H, C-H, and O-H nucleophiles or electroph

292 cent examples of electrophilic activation of allenes with particular focus on analogies and differenc

293 ination under Pd catalysis to deliver chiral allenes with pendant allylic amines.

294 opargylamines, which in turn give the chiral allenes with very high enantioselectivity via an intramo

295 ups, can be transformed to the corresponding allenes without loss of enantiopurity.

296 onto C-C multiple bonds such as alkynes and allenes without the involvement of free hydrogen iodide.

297 insertion of the internal double bond of an allene-yne has a higher barrier as it would break pi con

298 rs, intermolecular (5 + 2) cycloadditions of allene-ynes occur exclusively at the terminal allene dou

299 has been achieved by treating benzene-linked allene-ynes with aryldiazonium tetrafluoroborates and DA

300 moselectivity in (5 + 2) cycloadditions with allene-ynes.

301 double bond relative to the alkynyl group in allene-ynes.