ライフサイエンスコーパス: allergen

1 ficient (CD8(-/-)) mice were challenged with allergen.

2 ng of antibodies to multiple epitopes on the allergen.

3 1st and 5th challenges with diluent and with allergen.

4 se of cytokines and histamine in response to allergen.

5 the first epitope mapping of hIgE mAbs to an allergen.

6 Der p)2 and then exposed intranasally to the allergen.

7 al d 7 represents a novel major chicken meat allergen.

8 the presence of IL-2/alphaIL-2 complexes and allergen.

9 ent a single challenge with diluent and with allergen.

10 ptor for IgE, FcepsilonRI, and thereby sense allergens.

11 sulted in cross-protection against different allergens.

12 nd IgE epitopes were identified between both allergens.

13 complexity of the epitope structure of most allergens.

14 o other potential household contaminants and allergens.

15 t is exposed to a wide range of microbes and allergens.

16 thma is mediated by Th2 responses to inhaled allergens.

17 ate the immune response toward environmental allergens.

18 d stimulate bystander responses to unrelated allergens.

19 such proteins are easily missed as potential allergens.

20 ortant for lung response to signals, such as allergens.

21 allergens; (f) reimbursement for diagnostic allergens.

22 for the detection and quantification of food allergens.

23 food escalation (IFE) with a mix of up to 6 allergens.

24 and alpha-lactalbumin are major milk protein allergens.

25 ansfer polyproteins, which are common pollen allergens.

26 e ability of these benign proteins to become allergens.

27 ffer at different ages and between different allergens.

28 proteins can act either as tolerogens or as allergens.

29 th other reported triose-phosphate isomerase allergens.

30 specific IgE level (>=0.35 kU/L) for common allergens.

31 n IBH horses compared with controls for 25 r-allergens.

32 IgE responses to immunization with potential allergens.

33 -specific protein, named Aedes aegypti venom allergen-1 (AaVA-1), promotes dengue and Zika virus tran

34 Moreover, in comparison with allergens administered intradermally, powdered allergens

35 Despite involving the same causative allergens, allergy immunotherapy (AIT) treatment habits

36 Furthermore, analyses of the allergens' amino acid sequences indicated that they had

37 aged 12 to 36 months were assessed for food allergen and aeroallergen sensitization, atopic dermatit

38 sthmatic respiratory distress in response to allergen and airway hyperresponsiveness.

39 article discusses the recent developments in allergen and epitope discovery, allergy diagnostics and

40 The interaction between allergen and rhinovirus-induced symptoms and inflammatio

41 es that were specific for major grass pollen allergens and able to elicit basophil activation at very

42 was used to select marker peptides from four allergens and develop a quantitative method able to simu

43 responses to multiple extracts and molecular allergens and have several advantages for large cohort s

44 nd distribution of plant- and fungal-derived allergens and increases the frequency of extreme climate

45 e upper airways present a barrier to inhaled allergens and microbes, which alter immune responses and

46 o system we compared the effect of lipocalin allergens and nonallergenic homologues on human monocyte

47 uced by a panel of three naturally occurring allergens and novel delivery system of CSF1R inhibitor e

48 ism underlying ATP release induced by fungal allergens and suggests a possible therapeutic use for ch

49 MS method was optimized to measure known GCr allergens and their isoforms/variants in commercial extr

50 -test reaction biopsies against four contact allergens and two irritants were analyzed via microarray

51 We demonstrate in mouse models of allergen- and bleomycin-driven airway inflammation that

52 We also speculate on possible scenarios of allergen antigen presentation by MHC-I-like molecules to

53 Cr-PI/Per a 3 in ACR and two isoforms of the allergen Api m 1 (phospholipase A2: PLA2) in HBV.

54 ear IgE-binding epitopes of the major peanut allergen Ara h 2 and to produce a hypoallergenic variant

55 ntact and post-translationallycleaved peanut allergen Ara h 6 in relation to IgE-binding.

56 omologous allergens, as shown for the peanut allergens Ara h 1 and 2.

57 The residues of major peanut allergens Ara h 1, Ara h 2 and Ara h 6 were determined b

58 thetic overlapping 15-mer peptides of peanut allergens (Ara h 1-11) were spotted onto microarray slid

59 e, basic mechanisms, clinical mechanisms and allergens are all covered.

60 Diagnostic allergens are defined as medicinal products in the EU.

61 Four salmon allergens are well-characterized and registered with the

62 extracts was highly prevalent (43%-73%) but allergen arrays indicated that this was not attributable

63 s spectrometry identified the cross-reactive allergens as Der f 15 in HDM, two homologues of the Peri

64 the walnut Jug r 6 or that of nonhomologous allergens, as shown for the peanut allergens Ara h 1 and

65 sk factors include inhalant and occupational allergens, as well as genetic factors.

66 postinfection, or after a chronic cockroach allergen asthma model.

67 ity of the allergen, while precipitating the allergen at the injection site to reduce the risk of ana

68 urvive, while dampening immune reactivity to allergens, autoantigens and microbiome determinants.

69 mplification of authorization for diagnostic allergens; (b) specific regulation of special types of d

70 oach to search for allergens, identifying 16 allergens based on two-dimensional immunoblotting with A

71 Two types of allergen bioactivity, namely proteolysis and peptidolipi

72 -2011, and 2016-2017) to at least one of the allergens: birch, grass, house dust mite, or cat.

73 Fasting and excess of allergen, but not NSAID and exercise, were other relevan

74 ell phenotypes and can dampen T2 immunity to allergens, but its functions in controlling non-T2 cytok

75 ection method to recognize sIgE to molecular allergens by means of silicon dioxide (SiO(2)) NPs.

76 ient was examined for koayu fish and related allergens by skin prick and allergen-specific immunoglob

77 ic regulation of special types of diagnostic allergens; (c) new models beyond the current model of ho

78 Food allergens cause worldwide chronic diseases with a great

79 nsmitting infectious pathogens and source of allergens causing allergic conditions in animals and hum

80 The direct-instillation nasal allergen challenge (NAC) and the environmental exposure

81 ard Th1 and Th17 immunity, and protects from allergen challenge after only 2-4 monthly administration

82 ggest that elevation of ceramide level after allergen challenge contributes to the apoptosis, reactiv

83 Selection of a particular allergen challenge method should depend on consideration

84 Nasal and cutaneous allergen challenge tests were performed annually.

85 antly blunted the physiological responses to allergen challenge, and this effect persisted for at lea

86 x-expanded Treg cells could be recalled upon allergen challenge, which was associated with suppressio

87 hat the increases in lung ceramide levels in allergen-challenged mice are not mediated by oxidative s

88 s of SOCS3 were reduced in asthmatics and in allergen-challenged mice.

89 t group) were subjected to consecutive nasal allergen challenges (NAC) with seasonal (NAC-S) and pere

90 catalytically competent group 1 HDM protease allergen component is demonstrated by a review of disclo

91 e ImmunoCAP((R)) tests were negative for the allergen components rGad c 1 (pollackparvalbumin) and rP

92 le to elicit basophil activation at very low allergen concentrations.

93 ripts from peanut, soybean, sesame, and mite allergens contained a higher density of gaps than those

94 fins, yet little is known about the specific allergen content of muffins used in milk challenges or o

95 The allergen content of ragweed extracts was determined by m

96 This allergen could serve as a potent candidate for investiga

97 If the IgE binding sites on the allergens could be identified, it may be useful for crea

98 Combination of these top seven r-allergens could diagnose > 90% of IBH-affected horses wi

99 ogues of the Periplaneta americana cockroach allergen Cr-PI/Per a 3 in ACR and two isoforms of the al

100 Allergen cross-linking of the IgE/FcepsilonRI complex ac

101 lergens administered intradermally, powdered allergens delivered by means of PLD-MNA preferentially a

102 major shrimp allergen Pen m 1 and the minor allergens Der p 10 (dust mite), Bla g 7 (cockroach), and

103 ly validated with commercially available soy allergen detection lateral flow devices (LFDs).

104 t of a mass spectrometry method for multiple allergen detection, since specificity, robustness and se

105 onmental factors such as protease enzymes of allergens, detergents, tobacco, ozone, particulate matte

106 of cutaneous allergen exposure, we show that allergens directly activated TRPV1(+) sensory neurons le

107 The allergen displayed monomeric functional peptidyl-prolyl

108 sure of the skin to the experimental contact allergen DNFB results in a displacement of the normally

109 Allergen-driven airway inflammation was assessed in a mo

110 nses can be triggered even in the absence of allergens due to Pavlovian conditioning to a specific cu

111 Allergens elicit host production of mediators acting on

112 s response and down-regulation of the MalaS7 allergen-encoding genes.

113 CD301b(+) dermal DCs respond to allergens encountered in vivo, but not in vitro.

114 he complexity and subject-specific nature of allergen epitopes recognized following AIT.

115 ell as the body of evidence on environmental allergen exposure and how this can sensitize an individu

116 on mutations modify the relationship between allergen exposure and sensitization, but effects differ

117 Mucosal grass pollen allergen exposure by SLIT resulted in highly diverse IgE

118 tion and how this forms one half of the dual-allergen exposure hypothesis.

119 under the curve for the first 3 hours after allergen exposure in NAC or after initiation of exposure

120 Using a model of cutaneous allergen exposure, we show that allergens directly activ

121 nse-but only if participants had slept after allergen exposure.

122 D8(+) T(RM) cells to the epidermis following allergen exposure.

123 easure all known GCr allergens in commercial allergen extracts and environmental samples.

124 years were analyzed for IgE sensitization to allergen extracts by ImmunoCAP.

125 In high-income, temperate countries, IgE to allergen extracts is a risk factor for, and mediator of,

126 med with whole blood samples stimulated with allergen extracts of each nut (0.001-1000 ng/mL protein)

127 reduction of regulation fees for diagnostic allergens; (f) reimbursement for diagnostic allergens.

128 hicken meat revealed that Gal d 7 is a major allergen for patients primarily sensitized to chicken me

129 t Gal d 7 can be used as a diagnostic marker allergen for poultry meat allergy.

130 ur approach may be extended to other contact allergens for the further development of diagnostic and

131 A high level of IgE cross-reactivity towards allergens from the birch homologous group has been obser

132 of allergen-specific IgE to peanut/tree nut allergens from three IgE test platforms.

133 etry and related to T-cell epitopes of Amb a allergens (group 1, 3, 4, 5, 8 and 11) in 20 American ra

134 egistered with the WHO/IUIS while no catfish allergens have been described so far.

135 gen immunotherapy (AIT), numerous Culicoides allergens have been produced as recombinant (r-) protein

136 fferent ragweed species can be considered an allergen homology group with Amb a as the representative

137 We used a proteomic approach to search for allergens, identifying 16 allergens based on two-dimensi

138 Allergen Immunotherapy (AIT) was introduced in clinical

139 With the aim to improve allergen immunotherapy (AIT), numerous Culicoides allerg

140 New allergen immunotherapy forms are needed.

141 Allergen immunotherapy is a proven, safe treatment for r

142 Allergen Immunotherapy is an effective and safe treatmen

143 ensitivity after three weeks of subcutaneous allergen immunotherapy predicted the clinical outcome of

144 Allergen immunotherapy prescribed by a specialist using

145 Different allergen immunotherapy regimes are marketed but have low

146 y, including allergic rhinitis, aerobiology, allergen immunotherapy, asthma, dermatological diseases,

147 lost enabling the individual to consume the allergen in any amount at any time, can be envisioned.

148 t 22 DMPs was altered by diesel particles or allergen in human bronchial epithelial cells.

149 re clinical and immunologic responses to cat allergen in NAC versus EEC.

150 g an altered microbiome, air pollution, food allergens in a changed diet, and chemicals in modern det

151 nnial allergic asthma (PAA) caused by indoor allergens in adults with msAD.

152 nt of food allergy, that is, D pteronyssinus allergens in breast milk, which disrupt gut immune homeo

153 /MRM-MS can be used to measure all known GCr allergens in commercial allergen extracts and environmen

154 using LC-MS/MS as a method for detection of allergens in food is growing.

155 ansoni egg antigens (SmSEA) cross-react with allergens in natural rubber latex, peanuts and grass and

156 equency of FA and sensitization against food allergens in primary school children in eight European c

157 tailored to mitigate the risk of bovine milk allergens in the dairy processing and ingredients sector

158 the availability of high-quality diagnostic allergens in the EU, an action plan has been set up by E

159 However, the allergens in this fungus are still unknown, limiting the

160 IgE levels to 27 Culicoides r-allergens, including 8 previously unpublished allergens,

161 mine whether early-life exposure to inhalant allergens increases the risk of specific sensitization a

162 mily of small anti-microbial proteins, is an allergen independent of the carboxy-terminal fragment of

163 Allergens induce type-2 immunity, but unresolved questio

164 Grass pollen allergen induced cT(FH)-cell proliferation in the GPA gr

165 Both allergens induced massive pulmonary apoptosis and also s

166 mechanisms by which lung macrophages dampen allergen-induced airway inflammation.

167 increases in lung ceramide levels mitigated allergen-induced apoptosis, reactive oxygen species, and

168 tion in primary human mast cells and blocked allergen-induced contraction of isolated human bronchi.

169 Butyrate treatment inhibited allergen-induced histamine release and airway contractio

170 ypothesize that estrogen signaling increases allergen-induced IL-33 release, ILC2 cytokine production

171 which was beneficial to the host in reducing allergen-induced inflammation.

172 d by DBP.Conclusions: DBP exposure augmented allergen-induced lung function decline, particularly in

173 mmation, which translates to protection from allergen-induced lung function impairment.

174 llergen passage, allergic sensitization, and allergen-induced MC degranulation even in the absence of

175 LTC(4), but not LTD(4), strongly potentiates allergen-induced pulmonary eosinophilia in mice through

176 We profiled genome-wide allergen-induced Th-cell responses prospectively during

177 IL33 contributes to DEP mediated increase in allergen-induced Th2 inflammation and AHR in a mouse mod

178 potential for stable homeostatic control of allergen-induced Th2 responses via cross-regulation.

179 ase is typically associated with exaggerated allergen-induced type 2 immune responses, these response

180 pets, which limit exposure to environmental allergens, infectious parasitic worms, and microbes.

181 ronmental chamber followed immediately by an allergen inhalation challenge.

182 elial barrier that allows the penetration of allergens, irritants, and microbes into a cutaneous mili

183 hrough immunotherapy, continued ingestion of allergen is needed for most individuals to maintain dese

184 eeded before a cure, where reactivity to the allergen is permanently lost enabling the individual to

185 unting evidence that systemic uptake of food allergens is key to triggering anaphylaxis.

186 overall tendency to become sensitized to an allergen, is heritable but seldom ascribed to mutations

187 T-cell epitopes of multiple allergens/isoallergens are involved in the diverse T-cel

188 efined as a 75% or greater decrease in mouse allergen levels from baseline.

189 birth cohort we measured mite, cat, and dog allergen levels in dust samples collected from homes wit

190 ipants had 75% or greater reduction in mouse allergen levels.

191 s, sensory neurons act as primary sensors of allergens, linking exposure to activation of allergic-sk

192 Bioaccessibility of food allergens may be a key determinant of allergic reactions

193 We performed isoform-specific allergen measurements in multiple extracts from four com

194 IgE reactivity to 8 Phleum pratense (Phl p) allergens (MeDALL [Mechanisms for the Development of All

195 Eosinophilic esophagitis (EoE) is an allergen-mediated inflammatory disease with no approved

196 une/inflammatory responses against exogenous allergens, microbial substances, and pollutants might oc

197 When used, allergen mitigation should be allergen specific and incl

198 pollen sensitization and predict later ARg, allergen molecules are of added value to timothy extract

199 s to evaluate the usefulness of grass pollen allergen molecules for prediction of grass pollen allerg

200 well as grass pollen Phl p 1 and cat Fel d 1 allergen molecules may be related to specific pollutants

201 mon food and inhalant allergens, or specific allergen molecules, in children aged up to 16 years.

202 es (NAC) with seasonal (NAC-S) and perennial allergens (NAC-P).

203 The epitopes of the major allergen of pine nut, Pin p 1, were analyzed using a pep

204 AIT primarily to birch as the representative allergen of the Fagales tree homologous group, but furth

205 ELISA experiments, and cross-reactivity with allergens of other poultry species was assessed in inhib

206 Herein, we report that mite group 13 allergens of the fatty acid-binding protein (FABP) famil

207 llergens, including 8 previously unpublished allergens, of which 11 were expressed in more than one e

208 itis symptoms and positive SPT with seasonal allergens only (discrepant group) were subjected to cons

209 tagonist CCG203769 attenuated AHR induced by allergen or aspirin challenge of wild-type or ptges1(-/-

210 They must also not introduce a potential allergen or toxin.

211 dust matrix, through either their binding to allergens or their autonomous modulation of immune recep

212 nsitization against common food and inhalant allergens, or specific allergen molecules, in children a

213 The model allergen ovalbumin (OVA) was nitrated in different nitra

214 rier dysfunction facilitates transepithelial allergen passage, allergic sensitization, and allergen-i

215 s between four tropomyosins-the major shrimp allergen Pen m 1 and the minor allergens Der p 10 (dust

216 Treatment with grass allergen peptides led to an improvement in allergic rhin

217 s packaged with a mixture of powdered peanut allergen (PNA), 1,25-dihydroxyvitamin D(3) (VD3), and Cp

218 Allergen-polysaccharide neoglycogonjugates increase immu

219 Heat-and-pepsin-sensitive plant food allergens (PR-10 and profilin) sometimes cause systemic

220 n protocols yielded extracts with comparable allergen profiles and content.

221 Significant differences exist between allergen profiles of commercial extracts and the profile

222 (EEC) are 2 methods of conducting controlled allergen provocations.

223 Mouse allergen reduction is associated with greater increases

224 Mouse allergen reduction was defined as a 75% or greater decre

225 rsibility and including an interaction term (allergen reduction*time).

226 The allergen repertoire of raw and heated protein extracts w

227 We detail the allergen repertoire of two highly farmed fish species.

228 In this report, we aim to identify the allergens responsible for systemic allergic reactions fo

229 tivity of the Cor a 9, Cor a 11 and Cor a 14 allergens resulted to be stable after roasting at 140 de

230 Prevalence of food allergen sensitization (sIgE >= 0.35 kU(A) /L) varied by

231 eosinophilia, and goblet cell metaplasia in allergen-sensitized mice.

232 Methods: In a randomized crossover study, 16 allergen-sensitized participants were exposed to control

233 l cross-reactivity generally correlated with allergen sequence homology.

234 Cyclophilins are structurally conserved pan-allergens showing extensive cross-reactivity.

235 st mites (HDMs) are among the most important allergen sources containing many different allergenic mo

236 When used, allergen mitigation should be allergen specific and include multiple allergen-specific

237 However, allergen-specific analyses suggested increased risks of

238 s was evaluated by immunoblotting using five allergen-specific antibodies and patients' serum followe

239 Allergen-specific antibodies, splenocyte cytokine produc

240 ted food allergies through the production of allergen-specific antibodies.

241 body IgE class switch recombination of food allergen-specific B cells occurs, and what processes are

242 t altering the capacity to induce functional allergen-specific blocking antibodies.

243 eceptor (FcRN), and sensitized fetal MCs for allergen-specific degranulation.

244 ulating IgE(+) and IgG(+) memory B cells and allergen-specific Ig levels.

245 cted by a model that includes levels of free allergen-specific IgE and their interaction with blockin

246 have been successfully used for detection of allergen-specific IgE in patient sera.

247 ts model, we determined risks of transfer of allergen-specific IgE or IgG responses 24 months post-tr

248 stem cell transplantation profoundly reduces allergen-specific IgE responses but also comes with a co

249 Multiplex tests allow for measurement of allergen-specific IgE responses to multiple extracts and

250 undergoing stem cell transplantation, 94% of allergen-specific IgE responses were lost.

251 are involved in the immunological memory of allergen-specific IgE responses.

252 Allergen-specific IgE tests (ImmunoCAP ((R))) showed pos

253 create models for statistical integration of allergen-specific IgE to peanut/tree nut allergens from

254 Two years post-transplantation, recipients' allergen-specific IgE was significantly linked to the pr

255 Allergen-specific IgG, which served as a surrogate marke

256 In summary, we demonstrate non-allergen-specific immune network dysregulation in indivi

257 o comes with a considerable risk to transfer allergen-specific immune responses.

258 fish and related allergens by skin prick and allergen-specific immunoglobulin E (IgE) (ImmunoCAP((R))

259 9cRA signaling via RARalpha impacts the allergen-specific immunoglobulin response directly by th

260 ents from a double-blind, placebo-controlled allergen-specific immunotherapy (AIT) study indicated th

261 ted to mannan (PM) are suitable vaccines for allergen-specific immunotherapy (AIT).

262 ion at a global, allergome-wide level during allergen-specific immunotherapy (AIT).

263 Sublingual allergen-specific immunotherapy (SLIT) intervention impr

264 To date, no safe allergen-specific immunotherapy for patients with peanut

265 New strategies in allergen-specific immunotherapy have also emerged, such

266 chromatin landscape were observed following allergen-specific immunotherapy in cT(FH) and T(FR) cell

267 Allergen-specific immunotherapy is a disease-modifying t

268 othesis-driven approaches as contributing to allergen-specific immunotherapy outcomes, but understand

269 To address these limitations, adjunctive allergen-specific immunotherapy, vaccines, and non-aller

270 ld be allergen specific and include multiple allergen-specific mitigation strategies.

271 nd Th2 differentiation, and the induction of allergen-specific regulatory T cells, highlighting its p

272 ethods, we demonstrated the ability to model allergen-specific relationships with acceptable measures

273 obe ameliorated asthma pathologies including allergen-specific serum IgE production, allergic lung an

274 Recent studies have indicated that allergen-specific skin-resident memory T (T(RM)) cells p

275 virus-specific PD-1(+) T(H)1 cells, but not allergen-specific T(H)2 cells, were linked to worse lung

276 al (IN) nanoemulsion adjuvant that redirects allergen-specific Th2 responses toward Th1 and Th17 immu

277 en-specific immunotherapy, vaccines, and non-allergen-specific therapies (eg, monoclonal antibodies)

278 The fraction of allergen-specific/total IgE may be useful to predict pat

279 IL-31 levels were quantified in allergen-stimulated peripheral blood mononuclear cells (

280 he elucidation of cross-reactivity of marker allergens such as the walnut Jug r 6 or that of nonhomol

281 mation induced by protease-containing fungal allergens, such as Alternaria alternata, is not fully de

282 sensitization and challenge using a complete allergen that induces endogenous adjuvant activity.

283 tor for conserved FABPs found in common mite allergens that initiate type 2 immunity at mucosal surfa

284 se proteases are critical components of many allergens that provoke asthma.

285 TLR2 signalling and, in the case of protease allergens, the activation of additional pleiotropic effe

286 luated by applying patches containing cashew allergens to cashew-sensitized mice.

287 lergic reactions by specifically binding the allergens to which the allergic patients are sensitized.

288 Notably, application of allergen together with IL-2/alphaIL-2 complexes induced

289 ntrol of grass pollen allergy by maintaining allergen tolerance after cessation.

290 nsider the evolutionary origins of potential allergens, toxins and parasites, and how they might have

291 Allergen transcripts translate into proteins with a cati

292 p-Phenylenediamine (PPD) is a strong contact allergen used in hair dye that is known to cause allergi

293 tering the environmental context in which an allergen was administered a week earlier is sufficient t

294 ership, but the risk of sensitization to any allergen was significantly lower among children with FLG

295 IgE binding to almond extract and the allergens was analyzed by quantitative ELISA using sera

296 Transepithelial passage of allergens was evaluated on primary human nasal epithelia

297 Correlation between differently expressed r-allergens was usually high (mean = 0.69, range: 0.28-0.9

298 Furthermore, Gal d 7-cross-reactive allergens were also detected in other poultry species, s

299 ra-test correlations between PR-10 and nsLTP allergens were assessed.

300 ltaneously enhance the immunogenicity of the allergen, while precipitating the allergen at the inject

301 f related interest is the interaction of HDM allergens with common components of the house dust matri