ライフサイエンスコーパス: allergic response

1 in conjunctival tissue during an OVA-induced allergic response.

2 ucosal tissue that results in the late-phase allergic response.

3 s of mice undergoing house dust mite-induced allergic response.

4 signaling pathways in the initiation of the allergic response.

5 teolytic activity contributes to the overall allergic response.

6 poietin secretion and a cutaneous T-helper 2 allergic response.

7 possibly having a role in IgG modulation of allergic response.

8 (TSLP) secretion and a cutaneous T-helper 2 allergic response.

9 CFP to allergic recipients downmodulated the allergic response.

10 se are downregulated by Th2 cytokines of the allergic response.

11 development of Th2 cells and the subsequent allergic response.

12 nse to TSLP by CD4 T cells in vivo during an allergic response.

13 T mice, which did not exhibit an OVA-induced allergic response.

14 resentation, and (may) thereby influence the allergic response.

15 ature coincident with the suppression of the allergic response.

16 exercise-induced asthma, and the late-phase allergic response.

17 itical role in the development of Brazil nut-allergic response.

18 ing sensitization and challenge phases of an allergic response.

19 mast cells and basophils in the food-induced allergic response.

20 e promising candidates for modulation of the allergic response.

21 ls, and trigger inflammatory cascades of the allergic response.

22 te inflammatory pathways associated with the allergic response.

23 play pivotal roles in the initiation of the allergic response.

24 ell degranulation is a critical component of allergic response.

25 lium and influence the initiation of the HDM-allergic response.

26 ntibodies were the effector molecules of the allergic response.

27 tes mast cells and basophils, initiating the allergic response.

28 importance of B cells in maintenance of the allergic response.

29 r activation of the immune system during the allergic response.

30 ss to adenosine, could be useful to suppress allergic responses.

31 attempted to prenatally abolish or diminish allergic responses.

32 ipients fails to restore development of lung allergic responses.

33 demonstrated to contribute to modulation of allergic responses.

34 p110delta-selective inhibitor idelalisib on allergic responses.

35 relating ozone to respiratory infections and allergic responses.

36 Mast cells play an important role in allergic responses.

37 often leads to T helper 2 (Th2) cell-driven allergic responses.

38 ongylus brasiliensis to induce innate type 2 allergic responses.

39 resident Th2 memory cells as drivers of lung allergic responses.

40 that can both promote and curb Th2-dependent allergic responses.

41 t to function as an adjuvant that can induce allergic responses.

42 ling in Th2 cytokine-driven inflammation and allergic responses.

43 immunomodulatory properties of histamine in allergic responses.

44 ophils, which contribute to the pathology of allergic responses.

45 thought to play a role in the development of allergic responses.

46 Mast cells play critical roles in allergic responses.

47 's critical involvement in the regulation of allergic responses.

48 D25(+) T cells, enhanced development of lung allergic responses.

49 xploited therapeutically for modification of allergic responses.

50 supports its role as a mediator of immediate allergic responses.

51 DC migration and subsequent modification of allergic responses.

52 n CD4(+) T cells showed markedly ameliorated allergic responses.

53 exogenous stimulation and may contribute to allergic responses.

54 tions between them are essential to maximize allergic responses.

55 modulating adaptive immunity during chronic allergic responses.

56 major allergen and is responsible for severe allergic responses.

57 inase (PI3K) isoforms in sequential steps to allergic responses.

58 STAT6 plays a central role in IL-4-mediated allergic responses.

59 nsitization and whether recruitment promotes allergic responses.

60 e molecular interactions taking place during allergic responses.

61 hat has been implicated in the initiation of allergic responses.

62 is a costimulatory molecule involved in Th2 allergic responses.

63 otential proresolving therapeutic agents for allergic responses.

64 ng contributes to the effector phase of some allergic responses.

65 of the tissue microenvironment to subsequent allergic responses.

66 velopment of the full spectrum of intestinal allergic responses.

67 ion is critical for the development of acute allergic responses.

68 that CD8 T cells can both prevent and cause allergic responses.

69 and their skin was tested for cross-reactive allergic responses.

70 h are important effector cells in immune and allergic responses.

71 ns as a critical negative regulator to limit allergic responses.

72 l, viral, and fungal infections and in acute allergic responses.

73 es, extending beyond the regulation of acute allergic responses.

74 erminal centers and in the effector phase of allergic responses.

75 nd in Th2 cytokine production in established allergic responses.

76 tumors or pathogens, or dampen autoimmune or allergic responses.

77 , including parasite infections, cancer, and allergic responses.

78 ctive mediators induced by allergens elicits allergic responses.

79 t cells that contributes to inflammatory and allergic responses.

80 nducible Foxp3 expression and the control of allergic responses.

81 L-13-producing CD4(+) T cells mediating lung allergic responses.

82 irst direct evidence that nicotine modulates allergic responses.

83 ukotriene C(4) (LTC(4)), which contribute to allergic responses.

84 flammatory signaling, alleviating T(H)2-type allergic responses.

85 pe 2 immunity, which drives a broad array of allergic responses.

86 me pathogenic effector cells, enhancing lung allergic responses.

87 E structure and renders it unable to mediate allergic responses.

88 ce to further dissect tissue lymphocytes and allergic responses.

89 on IgE can be a potential target to inhibit allergic responses.

90 velopment of allergen-specific inhibitors of allergic responses.

91 ereby interfering with its ability to induce allergic responses.

92 ard infusion-related adverse effects such as allergic responses.

93 C2s) can also contribute to orchestration of allergic responses.

94 n part of the strong psychological impact on allergic responses.

95 of allergen-specific IgE that is central to allergic responses.

96 of targeting miR-19 to alleviate pathogenic allergic responses.

97 ight be a mechanism to suppress IgE-mediated allergic responses.

98 e of both high and low affinity epitopes for allergic responses.

99 lease, and forestalling initiation of type 2 allergic responses.

100 in Results: DBP exposure increased the early allergic response (21.4% decline in FEV(1) area under th

101 IgE, the antibody that mediates allergic responses, acts as part of a self-regulating pr

102 one of the most popular foods in the world, allergic responses after ingesting pizza are relatively

103 Lung function, early allergic response, airway responsiveness, inflammation,

104 Shedding light on the crosstalk between allergic response and cancer is paving the way for new a

105 suggests that a subset of ENMs may elicit an allergic response and contribute to the exacerbation of

106 tized to wheat proteins to induce a systemic allergic response and orally exposed to the same allerge

107 ILC2s have functional defects in the innate allergic response and represent a tool for studying inna

108 xes can be actively dissociated to block the allergic response and suggest that protein-protein compl

109 to study the molecules' ability to induce an allergic response and whether they induce allergen-speci

110 earch has not revealed how they initiate the allergic response and why the myriad of other inhaled pr

111 the effect of mast cell recruitment on acute allergic responses and (2) to define the role of phospho

112 but also had therapeutic effects on systemic allergic responses and airway hyperresponsiveness.

113 r role in human diseases beyond IgE-mediated allergic responses and antiparasitic functions.

114 ed ceramide levels in the lung contribute to allergic responses and asthma severity.

115 expert groups focus on the interface between allergic responses and cancer, applied to immune surveil

116 cytokines IL-13 and IL-4 are produced during allergic responses and cause increases in airway epithel

117 hemical challenges through AhR by modulating allergic responses and contributing to the generation of

118 the development of peanut-induced intestinal allergic responses and for prevention and treatment of p

119 Geha, they studied the role of Th2 cells in allergic responses and he began work in Kawasaki's disea

120 t by T helper 2 (Th2) cytokines that mediate allergic responses and IgE production.

121 l restoration of suppression of in vivo lung allergic responses and in vitro proliferation of activat

122 s, such as M pneumoniae, can augment ongoing allergic responses and inhibit pulmonary type 2 cytokine

123 the cytokine activin-A suppress TH2-mediated allergic responses and linked airway disease.

124 atopic march from skin sensitization to food allergic responses and provide a model system for the ge

125 red hallmarks of eosinophil participation in allergic responses and related inflammatory reactions; h

126 ays a significant role in the development of allergic responses and sensitivities, but the mechanisms

127 andin (PG) D(2) is substantially involved in allergic responses and signals through the 7 transmembra

128 omplex/FcepsilonRII/Syk/IFN-gamma pathway in allergic responses and suggest that FcepsilonRII may pla

129 the exact mechanisms of their involvement in allergic responses and Th2 cell differentiation have rem

130 ed that SP-D-deficient mice exhibit enhanced allergic responses and that SP-D induction requires lymp

131 quired for cellular and humoral Th2-mediated allergic responses and the development of airway hyperre

132 sed to investigate the pathogenesis of human allergic responses and to test new therapeutics before t

133 s from CD8(-/-) mice failed to suppress lung allergic responses and were characterized by reduced lev

134 between exposure to HDM, development of the allergic response, and pathologic consequences in patien

135 nticancer therapies, modulate autoimmune and allergic responses, and prevent transplant rejection.

136 ribute to protective immunity, inappropriate allergic responses, and tissue repair.

137 urring Foxp3(+)CD4(+)CD25(+) T cells on lung allergic responses are Ag-nonspecific and thus, independ

138 We review the myriad ways in which HDM allergic responses are orchestrated.

139 ollen lipids by iNKT cells and their role in allergic responses are poorly defined.

140 e also involved in autoimmunity, asthma, and allergic responses as well as in tumor immunity.

141 t have important roles in the development of allergic responses as well as the body of evidence on en

142 Transfer of nTreg cells enhanced lung allergic responses, as did transfer of iTreg cells.

143 importance of T helper type 2 (T(H)2)-driven allergic responses, as well as of the non-allergic and i

144 HFD-induced obesity potentiates food-induced allergic responses associated with dysregulated intestin

145 ability to induce allergic inflammation and allergic responses but induced similar T-cell proliferat

146 ence identifies histamine as a key player in allergic responses, but the reports relating serum hista

147 hoid cells (ILC2s) modulate inflammatory and allergic responses, but their function in cancer immunit

148 to pathogenic effector cells, enhancing lung allergic responses, but these effects were mediated thro

149 d a week earlier is sufficient to trigger an allergic response-but only if participants had slept aft

150 IL-4 secretion by ILC2s contributes to the allergic response by reducing allergen-specific Treg cel

151 ition during allergic sensitization augments allergic responses by enhancing Th2 cell activation and

152 ls are integral to the development of airway allergic responses by modulating chemokine and/or cytoki

153 ut of HDM allergens showed an attenuation of allergic responses by targeting just a single component,

154 the pathways leading to enhancement of lung allergic responses by transferred nTreg and iTreg cells

155 Our findings provide evidence that allergic responses can be conditioned to contextual info

156 Allergic responses can be triggered by structurally dive

157 Allergies are highly prevalent, and allergic responses can be triggered even in the absence

158 with allergic rhinitis and appears to reduce allergic responses clinically and immunologically after

159 Many forms of hypersensitivity reactions and allergic responses depend on deregulated mast cell activ

160 ensitization affects the airway and systemic allergic response differently.

161 to the steroid, dexamethasone, could inhibit allergic responses during the later stages of the diseas

162 and basophils, with release of agents of the allergic response, ensues when multivalent antigens bind

163 ndings demonstrate that Th2 cell-predominant allergic responses followed by immune phenotype switchin

164 b(-/-) mice were generated and exhibit hyper-allergic responses following antigen challenge.

165 T cells, developed the full spectrum of lung allergic responses following reconstitution with highly

166 Esophagitis, whether caused by acid reflux, allergic responses, graft-versus-host disease, drugs, or

167 istamines, which treat the symptoms after an allergic response has taken place; steroids, which resul

168 Although a role in pathogen and allergic responses has been assigned to the RORgammat(+)

169 Recruitment of APC and TC to the lung during allergic responses has been demonstrated, but functional

170 ction, the role of RasGRP4 in mast cells and allergic responses has not been clearly demonstrated.

171 TH2 differentiation and development of lung allergic responses has not been investigated.

172 ng TH2 effector activation in the late-phase allergic response, IL-10 is a known IgG1 switch factor.

173 these two epitopes completely abrogated the allergic response in 14 of the 16 patients in an in vitr

174 s complexed to polyphenol extracts to reduce allergic response in C3H/HeJ mice.

175 e effect of endotoxin in bedding dust on the allergic response in HDM-sensitised individuals.

176 noreactive peanut protein in relation to the allergic response in human.

177 ice were sufficient to confer an exaggerated allergic response in OVA-challenged WT mice, although ai

178 nical interest, as it has been implicated in allergic response in patients receiving therapeutic anti

179 nding was consistent with the lack of a full allergic response in SphK2-null mice challenged to under

180 allergic rhinitis (LAR) is a localized nasal allergic response in the absence of systemic atopy chara

181 reatment with butyrate significantly reduced allergic response in three animal models of FA, with a s

182 t CO(2) levels elicit a stronger RWE-induced allergic response in vivo and in vitro and that RWE incr

183 1 (H1R) and H4 receptors (H4R) in intestinal allergic responses in a model of peanut allergy.

184 mine whether IL-15(-/-) mice have attenuated allergic responses in a mouse model of AAD.

185 While DEP is known to augment allergic responses in adult animal models, its effects o

186 haride (LPS) prevented T helper 2 (Th2) cell allergic responses in adult, but not infant, mice.

187 port that IL-15(-/-) mice developed enhanced allergic responses in an OVA-induced model of AAD.

188 ole for CD206 in regulating allergen induced allergic responses in asthma.

189 gen attenuated the sensitizing potential and allergic responses in Balb/c mice significantly and coul

190 re, cHBIs demonstrated in vivo inhibition of allergic responses in both murine models.

191 ired for T helper type 2 (TH2), but not TH1, allergic responses in both the skin and lungs.

192 g a neutrophil-dependent enhancement of lung allergic responses in CD8(-/-) mice.

193 om Postn(+/+) mice was sufficient to promote allergic responses in F6 Postn(-/-) littermates.

194 Mast cells are a critical component of allergic responses in humans, and animal models that all

195 Increased airway allergic responses in Map3k8(-/-) mice were not due to a

196 1P and S1PR2 to MC- and IgE-dependent airway allergic responses in mice within minutes after antigen

197 adaptive humoral immune systems and modulate allergic responses in opposite directions, with sCD23 en

198 hts the importance of these cells for innate allergic responses in otherwise immunocompetent mice.

199 erized for its role during the initiation of allergic responses in peripheral tissues.

200 /-)and JNK2(-/-) mice failed to enhance lung allergic responses in sensitized and challenged CD8(-/-)

201 ted under hypoxic conditioning restored lung allergic responses in sensitized and challenged CD8-defi

202 nvestigate how nanoparticles (NPs) may alter allergic responses in skin.

203 the design topical therapeutics to mitigate allergic responses in skin.

204 The effects of IL-33 on allergic responses in the airways of sensitized mice wer

205 However, its relevance for the modulation of allergic responses in the lung remains unclear.

206 Enhanced allergic responses in the lung were accompanied by age-d

207 nal nematodes but is largely dispensable for allergic responses in the lung.

208 nin pathway in the DC-mediated regulation of allergic responses in the lung.

209 Eos) are the major inflammatory component of allergic responses in the lungs of active asthmatics.

210 en associated with the induction of Th2-type allergic responses in the lungs, is also expressed in hu

211 ng and to correlate these changes to chronic allergic responses in tissue.

212 uence of IgE on mast cell homeostasis during allergic responses in vivo has not been established.

213 Abs in promoting mast cell expansion during allergic responses in vivo.

214 apacity of transferred cells to restore lung allergic responses in vivo.

215 Systemic exacerbation of allergic responses, in which mast cells play a critical

216 interleukin-13 and hallmark features of the allergic response including airway hyperreactivity.

217 ransferred into CD8-deficient mice, and lung allergic responses, including airway hyperresponsiveness

218 ted and selective inhibition of IgE-mediated allergic responses, including food, environmental, and d

219 zed mice resulted in a dramatic reduction of allergic response, indicating the role of B cells in amp

220 tribution of the IL-33/ST2 signaling axis in allergic responses induced by bacterial allergens are di

221 exert strongly suppressive functions toward allergic responses induced by naive and in vivo-primed h

222 these compounds have been reported to induce allergic responses, inflammatory responses, or no respon

223 tudy, we humanized three parent low affinity allergic response inhibitor (LARI) mouse anti-human IgE

224 mpletely changed the paradigms of allergy as allergic response is directed against an oligosaccharide

225 al urban environment of Singapore, where the allergic response is dominated by a single allergen (hou

226 In a tropical urban environment, the allergic response is dominated by a single allergen clas

227 The allergic response is initiated on the plasma membrane of

228 ry cell (nTreg)-mediated suppression of lung allergic responses is abrogated following ligation of gl

229 While the role of IgE in mediating allergic responses is best described on basophils and ma

230 number of environmental proteins to provoke allergic responses is largely unknown.

231 ultimately mediates said innate and adaptive allergic responses is poorly understood.

232 In order for a protein to elicit a systemic allergic response it must reach the circulatory system t

233 ns with a focus on the role of basophils for allergic responses like asthma, allergic skin diseases a

234 wild-type mice, iTreg cells suppressed lung allergic responses linked to Smad3-dependent forkhead bo

235 Conceptually, allergic responses may involve cross-reactivity by antib

236 us propose a dual role for MALT1 protease in allergic response, mediating 1) IgE-dependent mast cell

237 e whether loss of Stard7 expression promotes allergic responses, mice were generated in which one all

238 Consequently we studied the allergic response of Fe(III) complex of the protein frac

239 udy we sought to determine if exposure to an allergic response of the pregnant female in utero would

240 h DCs participate specifically in initiating allergic responses, particularly those associated with a

241 rovide an effective therapeutic strategy for allergic responses, particularly those involving interac

242 inducing an immediate Type I (IgE-mediated) allergic response, proteins intended for use in consumer

243 their well-established role as regulators of allergic response, recent evidence supports a role for m

244 l functions have classically been related to allergic responses, recent studies indicate that these c

245 and the genetic etiology for differences in allergic responses remain unclear.

246 ls (nTregs) resulting in suppression of lung allergic responses requires interaction of MHC class I o

247 Functionally, T(H)9 cells promote allergic responses resulting in enhanced pathology media

248 Allergic responses, serological antibody levels, intesti

249 eading to initiation and exacerbation of the allergic response that might have implications for desig

250 o induce susceptibility to the inappropriate allergic responses that characterize atopy and asthma.

251 terobivalent inhibitor (HBI) of IgE-mediated allergic responses that selectively inhibits allergen-Ig

252 In the OVA-induced allergic response, the numbers of conjunctival mast cell

253 l compounds to control the initiation of the allergic response through engagement of innate immunity.

254 n test (BAT) has become a pervasive test for allergic response through the development of flow cytome

255 ty, play a role in the initiation of the HDM-allergic response through TLR2 activation.

256 IgG and FcgammaRIIb suppress adaptive allergic responses through effects on mast cell function

257 of peanut allergy, regulating peanut-induced allergic responses through effects on steroidogenesis, a

258 e postulated that SP-D may decrease adaptive allergic responses through interaction with T cells.

259 IgE has a key role in the pathogenesis of allergic responses through its ability to activate mast

260 +) T regulatory cells (nTregs) regulate lung allergic responses through production of IL-10 and TGF-b

261 Mast cells are known for their roles in allergic responses, thus in this study we sought to dete

262 hts their likely important role in the early allergic response to aeroallergens in the airways.

263 erapy can be used experimentally to treat an allergic response to another allergen and that the molec

264 common scientific name used to describe the allergic response to attacks in humans from nonspecific

265 ion, the inflammasome is dispensable for the allergic response to bee venom.

266 hese data demonstrate that IL-23 dampens the allergic response to cryptococcal infection through IL-1

267 aerostipes caccae, that protected against an allergic response to food.

268 Our mouse model of CRS displayed an allergic response to HDM + SEB administration, including

269 The allergic response to HDMs is partially mediated by epith

270 Allergic response to pollen is increasing worldwide, lea

271 eled and is based on initiation of a type II allergic response to specific food antigens, leading to

272 gatively charged silica (20 nm) NPs suppress allergic response to two chemically distinct sensitizers

273 ide immunotherapy can be exploited to reduce allergic responses to a second allergen, ovalbumin (OVA)

274 Suppression of allergic responses to cat allergen challenge was associa

275 estinal bacteria are critical for regulating allergic responses to dietary antigens and suggest that

276 with global WASP deficiency, indicating that allergic responses to food allergens are dependent upon

277 ering IL-25 signaling enhances or attenuates allergic responses to food allergens.

278 ate mechanisms underlying persistent IgE and allergic responses to food allergens.

279 ls leads to release of MMP-9 which decreases allergic responses to GC frass.

280 Allergic responses to HDM and other allergens are linked

281 Blockade of OX40L significantly lessened allergic responses to HDM or peanut.

282 and radiosensitive cells in the lung promote allergic responses to HDMs.

283 allergic asthma by TLR5-dependent priming of allergic responses to indoor allergens.

284 fic DNAzyme attenuated early- and late-phase allergic responses to inhaled allergen.

285 B cells, play a pivotal role in suppressing allergic responses to inhaled, ingested and injected all

286 tor for FLA, was required for priming strong allergic responses to natural indoor allergens present i

287 ion could be an important factor determining allergic responses to peanut.

288 envenomation and initiates inflammatory and allergic responses to venoms remain largely unknown.

289 oral immunotherapy is effective in reducing allergic responses towards shrimp tropomyosin.

290 Allergic response was analyzed ex vivo (basophil activat

291 Initially, the Th2-biased HDM allergic response was considered to be mediated only by

292 Enhancement of lung allergic responses was accompanied by reduced expression

293 rienes (cysLTs) are also produced during the allergic response, we investigated the possibility that

294 rs (IL-13 levels, eosinophil numbers) of the allergic response were assessed in bronchoalveolar lavag

295 These allergic responses were dependent on subtilisin protease

296 Local and systemic allergic responses were evaluated.

297 Food-induced allergic responses were quantified by using a clinical a

298 ial to modulate the elicitation phase of the allergic response which depends on the NP charge and com

299 mice enhanced the development of these lung allergic responses, which was reversed by exogenous IFN-

300 notherapy holds the potential for modulating allergic responses without IgE cross-linking.