ライフサイエンスコーパス: allodynia

1 increase in pain-like responses (mechanical allodynia).

2 ain, including pain aversion to light touch (allodynia).

3 UT3) neurons, which convey primarily dynamic allodynia.

4 emporally coincident with the alleviation of allodynia.

5 tassium current IKD in damage-triggered cold allodynia.

6 aintenance of vincristine-induced mechanical allodynia.

7 neuron hyperactivity and reversed mechanical allodynia.

8 ve neuronal type recruited during mechanical allodynia.

9 ensheathed nociceptors to sustain mechanical allodynia.

10 acrophage infiltration, oxidative stress and allodynia.

11 sts attenuated cortical theta and mechanical allodynia.

12 es not alter nerve injury-induced mechanical allodynia.

13 g siRNA against C/EBPbeta reduced mechanical allodynia.

14 hannels without producing heat or mechanical allodynia.

15 lization or PD-1 blockade induced mechanical allodynia.

16 phosphorylation leading to hyperalgesia and allodynia.

17 in severity of paclitaxel-induced mechanical allodynia.

18 xogenous IL-10 attenuated paclitaxel-induced allodynia.

19 t this contributes to neuropathic mechanical allodynia.

20 heral injury induced long-lasting (>1 month) allodynia.

21 recovery from paclitaxel-induced mechanical allodynia.

22 in WT mice attenuated neuropathic mechanical allodynia.

23 mPFC of SNI rats induced a decrease in cold allodynia.

24 eurons, which we show also convey mechanical allodynia.

25 1, which has been frequently associated with allodynia.

26 (C-fibers) has limited effects on mechanical allodynia.

27 e elusive dorsal horn circuit for mechanical allodynia.

28 in the development of significant mechanical allodynia.

29 tely reversed oxaliplatin-induced mechanical allodynia.

30 ain without affecting the sensory mechanical allodynia.

31 genesis that are associated with neuropathic allodynia.

32 critical for expression of hyperalgesia and allodynia.

33 ritical role in the expression of mechanical allodynia.

34 l cord dorsal horn only in mice with ongoing allodynia.

35 ceptive deficits and fail to develop tactile allodynia.

36 ncreased thermal hyperalgesia and mechanical allodynia.

37 been implicated in the expression of tactile allodynia.

38 produced long-lasting generalized cutaneous allodynia.

39 , but also alleviated SNI-induced mechanical allodynia.

40 echanotransduction contributes to mechanical allodynia.

41 selective antibody attenuated the associated allodynia.

42 rs display decreased Cirl1 expression during allodynia.

43 butes to centrally mediated hyperalgesia and allodynia.

44 tration in rodent models of hyperalgesia and allodynia.

45 e to peripheral inflammation-induced tactile allodynia.

46 810 or HC030031 reduced spinal HXA(3)-evoked allodynia.

47 all running activity and greater reversal of allodynia.

48 ous and long-lasting pain, hyperalgesia, and allodynia.

49 ons and in a rat behavioral model of thermal allodynia.

50 f SNC80 to inhibit PGE(2)-stimulated thermal allodynia.

51 ileuton) dose-dependently attenuated tactile allodynia.

52 resence of pain was confirmed by testing for allodynia.

53 natomical source of the influence of CGIC on allodynia.

54 tial sciatic nerve injury-induced mechanical allodynia.

55 hdrawal thresholds as a surrogate readout of allodynia.

56 ect intraplantar ODN 1826-induced mechanical allodynia.

57 ion of Cn2 causes mechanical but not thermal allodynia.

58 ing its reduced ability to induce mechanical allodynia.

59 lly mediating throbbing headache and cranial allodynia.

60 points at which they recover from mechanical allodynia.

61 rs was required for TRPA1-induced mechanical allodynia.

62 ylfumarate (DMF) and BHB reduced the tactile allodynia.

63 itivity and cold allodynia, but not for heat allodynia.

64 nimals recover from the initial CGRP-induced allodynia.

65 physiological temperature detection and cold allodynia.

66 spontaneous burning pain, hyperalgesia, and allodynia.

67 ssay for measuring functional and mechanical allodynia.

68 for oxidative and carbonyl stress, prevented allodynia.

69 ers is increased, and results in severe cold allodynia.

70 i promotes recovery from mechanical and cold allodynia.

71 yperalgesia after SNL, but it increases cold allodynia 6h after application.

72 nerve injury, effectively reduced mechanical allodynia, a cardinal feature of late-phase neuropathic

73 d in the absence of any effect on mechanical allodynia, a standard test for neuropathic pain efficacy

74 Those who reported cranial allodynia accompanying their spontaneous migraine attack

75 d allodynia to dissect the framework of cold allodynia-activated central pain pathways.

76 -314) dose-dependently suppresses mechanical allodynia after chemotherapy, nerve injury, and diabetic

77 contribute to the development of mechanical allodynia after L5 spinal nerve ligation.

78 All strains variously developed mechanical allodynia after SNI with the exception of stress-hypores

79 ave previously been implicated in mechanical allodynia, an A-fiber-selective pharmacological blocker

80 of headache and the development of cutaneous allodynia and central sensitization.

81 targeted O2(.-)scavenger) reduced mechanical allodynia and decreased pCREB and pC/EBPbeta.

82 ceiving verum treatment developed mechanical allodynia and distinct gait alterations.

83 males had distinct differences in mechanical allodynia and DRG gene expression, even though sex diffe

84 s time, BAMBI-KO mice were protected against allodynia and exhibited increased expression and functio

85 interleukin-35 (IL-35) in suppressing facial allodynia and facial grimacing in animals with experimen

86 tly attenuated paclitaxel-induced mechanical allodynia and heat hyperalgesia.

87 (Hh) signaling is required for both thermal allodynia and hyperalgesia following ultraviolet irradia

88 n and potentially related conditions such as allodynia and hyperalgesia in a comparative setting that

89 All hybrids alleviated allodynia and hyperalgesia in neuropathic pain models.

90 in the RVM, before or after SNI, attenuates allodynia and hyperalgesia in rats.

91 zation in the pain neuraxis, associated with allodynia and hyperalgesia observed in patients with chr

92 Visceral hypersensitivity, including allodynia and hyperalgesia, abnormal colonic transit, an

93 ate-phase neuropathic pain symptoms, such as allodynia and hyperalgesia, for several weeks in murine

94 b did not affect centrally mediated referred allodynia and hyperalgesia.

95 IM1alpha expression reversed the SNL-induced allodynia and increased spontaneous EPSC (sEPSC) frequen

96 n leads to recovery from mechanical and cold allodynia and increases the motivation for wheel running

97 ry K(+), prevented the development of pelvic allodynia and inflammation seen in rats expressing Cldn2

98 of inflammatory hyperalgesia and neuropathic allodynia and is devoid of ancillary cardiovascular or C

99 thanol ingestion caused prolonged mechanical allodynia and loss of intraepidermal small nerve fibers

100 ificantly increased and sustained mechanical allodynia and loss of motor function.

101 xynucleotide against CREB reduced mechanical allodynia and lowered pC/EBPbeta.

102 ta fibers, giving rise to dynamic mechanical allodynia and mechanical hyperalgesia.

103 ronic constriction injury (CCI) induced cold allodynia and models of inflammatory and neuropathic pai

104 artan to mice in drinking water reduced both allodynia and muscle fibrosis.

105 RPA1 silencing in Schwann cells reduced both allodynia and neuroinflammation.

106 id, prevents nerve injury-induced mechanical allodynia and ongoing pain in mice.

107 e-specific trkB.T1 KO mice; using mechanical allodynia and pain-related measurements on the CatWalk,

108 litating disease characterized by mechanical allodynia and spontaneous pain.

109 Despite severe allodynia and structural knee joint damage equal to wild

110 ter SNI, wild-type mice developed mechanical allodynia and the functionality of mu-opioid receptors w

111 significantly blocked CFA-induced mechanical allodynia and thermal hyperalgesia 1 day post-CFA inject

112 ute pain perception, and reversed mechanical allodynia and thermal hyperalgesia in a model of neuropa

113 , cis-(+)-37 was effective at reversing both allodynia and thermal hyperalgesia in a standard Chung (

114 ical scores of EAE and attenuated mechanical allodynia and thermal hyperalgesia in EAE.

115 mice exhibited similar levels of mechanical allodynia and thermal hyperalgesia to wild-type mice but

116 t tibial fracture with pinning triggers cold allodynia and up-regulates nerve injury and inflammatory

117 gly, peripheral nerve injury induces tactile allodynia and upregulates Ca(V)3.2 channels and cyclin-d

118 pain threshold, mechanical pain sensitivity, allodynia and/or windup), yielded four phenotypes of fib

119 be accompanied by abnormal skin sensitivity (allodynia) and muscle tenderness.

120 ynucleotide against TNFRI reduced mechanical allodynia, and decreased mtO2(.-), pCREB and pC/EBPbeta.

121 elta attenuated spontaneous pain, mechanical allodynia, and heat hyperalgesia in TOW mice.

122 ansit time (radiopaque markers); compliance, allodynia, and hyperalgesia (rectal barostat); anxiety a

123 ensory nerve conduction velocity, mechanical allodynia, and loss of intraepidermal nerve fibres.

124 d decreases in mechanical hyperalgesia, cold allodynia, and sciatic nerve conduction velocity.

125 s sufficient to induce persistent mechanical allodynia, and this allodynia was suppressed by CXCL1 ne

126 iors, including somatic signs of withdrawal, allodynia, anxiety-like behavior, and relapse-like behav

127 al neuropathic pain that includes mechanical allodynia are limited.

128 Therefore, NGF-evoked thermal and mechanical allodynia are mediated by spatially distinct mechanisms.

129 many migraineurs, whose symptoms of cranial allodynia are responsive to triptan treatment.

130 rsed oxaliplatin-induced cold and mechanical allodynia as well as social interaction impairment.

131 Cranial allodynia associated with spontaneous migraine is report

132 11.5 mg/kg ip), an oxaliplatin-induced cold allodynia (at 10-30 mug sc), and CCI-induced thermal hyp

133 r HXB(3) evoked profound, persistent tactile allodynia, but 12(S)-HpETE and HXA(3) produced relativel

134 tion of mechanical hypersensitivity and cold allodynia, but not for heat allodynia.

135 the induction and maintenance of mechanical allodynia, but the circuitry that underlies this clinica

136 ice that lack Ccr2 also developed mechanical allodynia, but this started to resolve from 8 wk onwards

137 ation of 18.1 +/- 3.4 d delayed the onset of allodynia by 1 mo.

138 of block 6.9 +/- 1.2 d) delayed the onset of allodynia by 2 d.

139 n suggested that they play a crucial role in allodynia by modulating voltage-gated calcium channel cu

140 and 4-hydroxynonenal (4-HNE), which sustains allodynia by paracrine targeting of nociceptor TRPA1.

141 contribute more to the maintenance phase of allodynia by redirecting tactile information to the cort

142 basal mechanical sensitivity and mechanical allodynia by regulating auxiliary voltage-gated calcium

143 Spontaneous tonic pain and evoked allodynia can be experimentally dissociated.

144 rmalized mechanical hyperalgesia and tactile allodynia caused by SNL but had no significant effect on

145 sociated with the pathogenesis of mechanical allodynia, changes in cortical circuits also accompany p

146 ine attacks, we investigated whether cranial allodynia could be triggered experimentally, observing i

147 Paclitaxel-induced mechanical and cold allodynia developed to an equivalent degree in CB1KO, CB

148 Moreover, tactile allodynia did not develop as an unwanted side effect in

149 has a role in the development of mechanical allodynia during neuropathic pain.

150 nerve ligation (SNL), in addition to causing allodynia, enhances the Rab3-interactive molecule-1alpha

151 s in the PNS were associated with mechanical allodynia, even in the absence of nerve injury.

152 lateralized and in proportion to the tactile allodynia exhibited by SNI animals.

153 nd that the model provided robust mechanical allodynia, fibrosis and a shift to smaller average muscl

154 3CR1 exhibited a delay in the development of allodynia following VCR administration.

155 nisms for the development and maintenance of allodynia have been investigated in the spinal cord, bra

156 ctivity; these changes probably underlie the allodynia, hyperalgesia, and spontaneous pain seen in pa

157 which may cause several symptoms, including allodynia, hyperalgesia, anxiety, and depression.

158 ndicate that EA at 10 Hz inhibits mechanical allodynia/hyperalgesia more potently than does EA at 100

159 ared nerve injury (SNI) developed mechanical allodynia in 1 wk; nerve blockade with a single dose of

160 on of all three gelatins reduced measures of allodynia in a chronic, neuropathic sciatic nerve injury

161 of the TAT-4BB reversed M3G-induced tactile allodynia in a dose-dependent manner but did not affect

162 IL10 combination therapy and also inhibited allodynia in a mouse model of neuropathic pain.

163 olecule 20 (AM-1488), which reversed tactile allodynia in a mouse spared-nerve injury (SNI) model.

164 selective S1P(2) agonist, CYM-5478, reduces allodynia in a rat model of cisplatin-induced neuropathy

165 By contrast, gabapentin suppressed allodynia in both CFA and PSNL models.

166 V1 in TRPM8(+) sensory neurons leads to cold allodynia in both corneal and non-corneal tissues withou

167 the TLR9 agonist ODN 1826 induced mechanical allodynia in both sexes of WT and Tlr4 KO mice but faile

168 axel-activated macrophages evoked mechanical allodynia in both sexes, which was compromised by Tlr9 m

169 2-mediated suppression of paclitaxel-induced allodynia in CB1KO mice; these antiallodynic effects wer

170 a lesser extent, also diminishes mechanical allodynia in CCI in female mice.

171 In conclusion, MrgprD is essential in cold allodynia in CCI-induced neuropathic pain through the PK

172 )1.8 and Lgmn deletion attenuated mechanical allodynia in female mice with carcinogen-induced OSCC.

173 gonism reduced paclitaxel-induced mechanical allodynia in female nude mice (T-cell and B-cell deficie

174 n able to activate the HCAR2-reduced tactile allodynia in female WT mice, but not in the HCAR2-null m

175 utoimmune encephalomyelitis (EAE) and facial allodynia in immunized female mice.

176 Here we show that mechanical allodynia in male mice was increased with exposure to RS

177 PD-L1 or PD-1 elicited spontaneous pain and allodynia in melanoma-bearing mice.

178 We observed persistent mechanical allodynia in mice lacking MKP-3 (postoperative day 21),

179 f CX3CR1 alleviated gp120-induced mechanical allodynia in mice, suggesting a critical contribution of

180 allowed to halve the dose totally relieving allodynia in mice.

181 a sustained inhibition of paclitaxel-induced allodynia in mice.

182 ethanol ingestion caused delayed mechanical allodynia in mice.

183 s also attenuated protease-evoked mechanical allodynia in mice.

184 tive was to study triptan-responsive cranial allodynia in migraine patients, and to develop an approa

185 CL13-activated astrocytes induced mechanical allodynia in naive mice.

186 with hyperbaric oxygen alleviated mechanical allodynia in nerve-injured animals.

187 we report that the mechanical threshold for allodynia in paclitaxel-treated rats exhibited a robust

188 genated fatty acids (EpFAs), greatly reduces allodynia in rats caused by streptozocin-induced type I

189 ed naloxone-sensitive reversal of mechanical allodynia in rats following chronic constriction injury

190 rved marked increases in mechanical and cold allodynia in rats of both sexes that were maintained on

191 ertain whether HBO2 treatment might suppress allodynia in rats with neuropathic pain and whether this

192 cord prevented the development of mechanical allodynia in RSD-exposed mice.

193 ctive and reliable method to trigger cranial allodynia in subjects during evoked migraine, and the sy

194 eversible enzyme inhibition, 3 reversed cold allodynia in the chronic constriction injury model of ne

195 he development of acute and chronic cephalic allodynia in the chronic nitroglycerin model, an effect

196 hat the neural circuits conveying mechanical allodynia in the dorsal horn differ by the nature of the

197 f an etiology-based circuitry for mechanical allodynia in the dorsal horn has important implications

198 Rats develop hyperalgesia and allodynia in the hind paw after L5 spinal nerve ligation

199 tribute directly to the pathogenesis of cold allodynia in the rat SNL model, but it is a potential me

200 the inferior alveolar nerve (IANx) produces allodynia in the whisker pad (V2 division) of rats.

201 erequisite of vincristine-induced mechanical allodynia in this model.

202 Importantly, P7C3-A20 blocked PTX-induced allodynia in tumored mice without reducing antitumoral e

203 respectively) and carrageenan-evoked tactile allodynia in vivo.

204 n vitro as well as PGE(2)-stimulated thermal allodynia in vivo.

205 hecal injection of 5,6-EET caused mechanical allodynia in wild-type but not TRPA1-null mice.

206 daily, i.p. ) suppressed paclitaxel-induced allodynia in WT and CB2KO mice, but not CB1KO mice.

207 of AM1710 also attenuated paclitaxel-induced allodynia in WT mice, but not CB2KO mice, implicating a

208 delivery of SerpinA3N attenuated mechanical allodynia in WT mice.

209 HC suppressed established paclitaxel-induced allodynia in WT mice.

210 athic mice.SIGNIFICANCE STATEMENT Mechanical allodynia, in which innocuous touch is perceived as pain

211 We found that cold allodynia induced by chronic constriction injury (CCI) o

212 b.i.d. for 3 d, intraperitoneal) suppressed allodynia induced by chronic constriction injury of the

213 .p.) did not suppress established mechanical allodynia induced by complete Freund's adjuvant (CFA) or

214 GAT211 suppressed allodynia induced by complete Freund's adjuvant and the

215 Here, we show that cold allodynia induced by inflammation, nerve injury, and che

216 neurons in lamina II inner convey mechanical allodynia induced by inflammatory injuries, while protei

217 t the lamina II/III border convey mechanical allodynia induced by neuropathic injuries.

218 de significantly attenuated hyperalgesia and allodynia induced by paclitaxel.

219 unctional expression in rats with mechanical allodynia induced by spinal nerve ligation (SNL).

220 Mechanical allodynia, induced by normally innocuous low-threshold m

221 ensitivity is controlled in nociceptors, and allodynia involves TrkB(+) light-touch mechanoreceptors.

222 Mechanical allodynia is a cardinal feature of pathological pain.

223 Cold allodynia is a common symptom of neuropathic and inflamm

224 Furthermore, established cold allodynia is blocked in animals treated with neutralizin

225 Together, our results suggest that cold allodynia is largely due to a functional downregulation

226 Our results suggest that cold allodynia is linked to a reduction of IKD in both high-t

227 izing other modalities after an insult, cold allodynia is mediated exclusively by a single molecular

228 g neuropathic pain, and nerve damage-induced allodynia is reduced in Epac1-/- mice.

229 pain disorders in which hyperalgesia and not allodynia is the primary symptom.

230 ute to the intense sensation associated with allodynia is unclear.

231 Nonetheless, cold pain (allodynia) is prevalent in many inflammatory and neuropa

232 n (10 mug, 10 mul; i.t.) reduced SNL-induced allodynia, kalirin and pNR2B expression, as well as kali

233 echanoreceptors (Abeta-LTMRs) for mechanical allodynia-like behaviors in mice, but it remains unclear

234 etreatment with l-THP reduced the mechanical allodynia (MA) induced by direct activation of sigma-1 r

235 acological inhibition reduced the persistent allodynia observed in these mice.

236 Cold allodynia occurs as a major symptom of neuropathic pain

237 y pain, thermal hyperalgesia, and mechanical allodynia, of which the latter is completely dependent o

238 f icilin (0.1nM to 1microM) affected tactile allodynia or thermal hyperalgesia after SNL, but it incr

239 required during the initiation of mechanical allodynia or thermal hyperalgesia, these cells may not b

240 eloped after 1 week while THC or CBD reduced allodynia over three weeks.

241 We describe the defining feature of the cold allodynia pain percept in the human brain and illustrate

242 indings, real rTMS significantly reduced hot allodynia pain ratings.

243 Tactile allodynia produced by placing a plastic cuff around the

244 Surprisingly, Merkel cells also mediate allodynia, providing a new cellular target for chronic p

245 , and cold hyperalgesia but tactile and cold allodynia remain following peripheral nerve injury.

246 and whether it has a causal relationship to allodynia remain unsolved.

247 of a translational approach to study cranial allodynia reported in migraine patients is a limitation

248 tent thermal hypersensitivity and mechanical allodynia require de novo protein translation and are me

249 day 12, while both MAPK phosphorylation and allodynia resolved on postoperative day 7 in wild-type m

250 the loss of tactile sensitivity and tactile allodynia seen in patients who have diabetes, inflammato

251 eral manifestations of the neuropathic state-allodynia, sensory loss, shooting pains, etc, that can m

252 SNL contributes nerve injury-induced tactile allodynia.SIGNIFICANCE STATEMENT Neuropathic pain is a c

253 Such cutaneous allodynia suggests a state of 'central sensitization' of

254 pinA3N developed more neuropathic mechanical allodynia than wild-type (WT) mice, and exogenous delive

255 pe mice, oxaliplatin treatment produced cold allodynia that could be prevented by RgIA4.

256 l dental injury develop bilateral mechanical allodynia that is delayed relative to the onset of spont

257 In vivo, 8-pCPT induces long-lasting allodynia that is prevented by the knockdown of Epac1 an

258 e developed early-onset secondary mechanical allodynia that was maintained for 16 wk.

259 Mechanical allodynia - the misperception of light touch as painful

260 e Trpa1fl/fl mice did not develop mechanical allodynia, they did not show any protection from the sma

261 ignificantly reduced the nerve crush-induced allodynia; this anti-allodynic effect of HBO2 was revers

262 rsistent thermal hyperalgesia and mechanical allodynia to determine the role of transient receptor po

263 We used CTXs as a surrogate model of cold allodynia to dissect the framework of cold allodynia-act

264 ch as respiratory suppression, constipation, allodynia, tolerance, and dependence, as well as abuse p

265 In a murine model of chemotherapy-induced allodynia, VCR treatment induced upregulation of endothe

266 al and spinal sites of action and mechanical allodynia via only a spinal site of action.

267 and reversed inflammation-induced mechanical allodynia via peripheral adenosine A1 receptor activatio

268 ns of heat on capsaicin-sensitized skin, hot allodynia was assessed during 3 Tesla functional magneti

269 Together, RSD-induced allodynia was associated with microglia-mediated inflamm

270 ce, chemotherapy-induced development of cold allodynia was attenuated and the milder, temporary cold

271 development of paclitaxel-evoked mechanical allodynia was attenuated by TLR9 antagonism or Tlr9 muta

272 Reversible cold allodynia was induced in healthy male volunteers by shal

273 of diabetes-induced retinopathy and tactile allodynia was investigated.

274 Spinal RIM1alpha-associated allodynia was mediated by Fbxo3, which abates Fbxl2-depe

275 as attenuated and the milder, temporary cold allodynia was not relieved by RgIA4.

276 Allodynia was observed in 36% of patients, hyperalgesia

277 Paclitaxel-induced mechanical allodynia was prolonged in T-cell-deficient (Rag1(-/-))

278 Moreover, injury-induced tactile allodynia was reversed by inhibiting and exacerbated by

279 The SNE-induced mechanical allodynia was reversibly suppressed, partially or comple

280 anglion neurons and, importantly, mechanical allodynia was significantly attenuated in conditional Na

281 ce persistent mechanical allodynia, and this allodynia was suppressed by CXCL1 neutralization, CXCL1

282 ar cortex lesion, even though the mechanical allodynia was suppressed.

283 Cranial allodynia was triggered alongside migraine-like headache

284 s (LTMRs) to nerve-injury-induced mechanical allodynia, we generated and characterized a new transgen

285 Brain areas that responded during cold allodynia were almost always located bilaterally and app

286 and superoxide production in the retina and allodynia were inhibited in diabetic animals in which iN

287 istic of the early stages of retinopathy and allodynia were measured in chimeric mice lacking inducib

288 Impaired RDD and allodynia were present in type 1 and type 2 diabetic rat

289 ons may result in the development of tactile allodynia, where non-painful stimuli gain the capacity t

290 d females display a severe sustained tactile allodynia which is reduced by gabapentin but not the pot

291 ly-phase analgesia and late-phase mechanical allodynia which requires NMDAR; both phases are prolonge

292 persensitivity to cold or mechanical-induced allodynia, which are established tests to assess acute o

293 n sensory perception, such as photophobia or allodynia, which have in common an uncomfortable amplifi

294 of NMDA induces GluN2B-dependent mechanical allodynia, which is prolonged in Arrb2-KO mice and condi

295 e Sprague Dawley rats resulted in behavioral allodynia, which was associated with phosphorylated SGK1

296 luR5-signaling pathway suppressed mechanical allodynia, while activating this pathway in the absence

297 2 agonists for managing chemotherapy-induced allodynia with a favorable therapeutic ratio marked by s

298 ement in potency in vivo, evoking mechanical allodynia with an EC(5)(0) of 14.4 pmol.

299 tors prevented the development of mechanical allodynia without affecting clinical signs and disease p

300 lencing in nociceptors attenuated mechanical allodynia, without affecting macrophage infiltration and